Title - COMBINATIONS OF ACTIVE COMPOUNDS AND FUNGICIDAL COMPOSITIONS COMPRISING THEM
Patent Information
- Application Number
- ARP20210100969
- Authority / Receiving Office
- AR · AR
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-04-16
- Filing Date
- 2021-04-12
- Publication Date
- 2026-08-26
- Estimated Expiration
- 2041-04-12
Abstract
Description
COMBINATIONS OF ACTIVE COMPOUNDS AND FUNGICIDAL COMPOSITIONS COMPRISING THEM The present invention relates to combinations of active compounds comprising, as compound (A), methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, or a mixture thereof, as compound (B), isoflucipram, and as compound (C), at least one additional respiratory chain inhibitor in complex I or II. Furthermore, the invention relates to fungicidal compositions comprising such a combination of compounds and to the use of the compound combinations and fungicidal compositions as biologically active agents, particularly for the control of phytopathogenic fungi in crop protection and in the protection of industrial materials, and as plant growth regulators. Throughout this application, the terms composition and formulation are used synonymously and refer to mixtures of a combination of compounds of the invention and at least one agriculturally suitable auxiliary. The compounds methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate and 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, their preparation and their fungicidal efficacy have been disclosed by WO 2019 / 093522 A1. WO 2019 / 093522 A1 also discloses compositions comprising at least one of these compounds, and furthermore also combinations of active compounds comprising at least one of these compounds and at least one additional active ingredient, in particular an additional fungicide. The compounds methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, and known combinations of compounds comprising any of these compounds provide an excellent means of protecting plants from fungal diseases. However, there is still a need to further improve these means in order to address the ever-increasing environmental and economic demands placed on today's crop protection agents and compositions. This includes, for example, improving the spectrum of activity, safety profile, selectivity, application rate, residue formation, and ease of preparation, as well as developing new compositions to address potential problems such as resistance. The present invention provides combinations of active compounds and compositions comprising such combinations that at least in some respects achieve the stated objective. Accordingly, the present invention provides combinations of active compounds comprising 237470 1336027 of 49 (A) methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid or a mixture thereof, (B) isoflucipram, and (C) at least one additional active compound selected from the group of respiratory chain inhibitors in complex I or II, wherein the at least one additional active compound (C) is different from compounds (A) and (B). The active compound combinations according to the invention comprise, as compound (A), methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, or a mixture thereof, wherein the compounds may be present in the form of a salt or N-oxide thereof. The salts or N-oxides of said compounds also have fungicidal properties. The compound methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate is represented by the formula (I-1) (I-1) and henceforth is also referred to as compound (I-1) or simply (I-1). The compound 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid is represented by the formula (I-2) (I-2) and henceforth is also referred to as compound (I-2) or simply (I-2). 237470 1336027 of 49 Compound (I-1), compound (I-2) and their mixtures are hereafter collectively referred to as compound (I) or simply (I). As evidenced by formulas (I-1) and (I-2), compounds (I-1) and (I-2) comprise a stereogenic center at the carbon atom bearing the hydroxyl group. Consequently, the compounds may exist as optical isomers, their racemic or scalemic mixtures (the term scalemic denotes a mixture of enantiomers in different proportions), in all proportions. Compounds (I-1) and (I-2) can be used in the active compound combinations according to the present invention in any of these forms, i.e., (I-1) can be present as methyl (2R)2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, methyl (2S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, the racemate of methyl (2R)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, and methyl (2S)-2-[2-chloro-4-(4chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate,and any scalemic mixture of methyl (2R)2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate and methyl (2S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, and (I-2) may be present as (2R)2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, (2S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, the racemate of acid (2R)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid and (2S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid, and any scalemic mixture of (2R)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid and (2S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid. Preferably, the combinations of active compounds according to the invention comprise compound (A) compound (I-1). The combinations of active compounds according to the invention comprise compound (B) isoflucipram. Isoflucipram is the common name for N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-carboxamide, also called N-[(5-chloro-2-isopropylphenyl)methyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-pyrazol-4-carboxamide, which has CAS Reg. No. 1255734-28-1. Hereafter isoflucipram is also referred to as compound (II) or simply (II). The combinations of active compounds according to the invention further comprise at least one compound (C) selected from respiratory chain inhibitors in complex I or II, wherein the at least one additional active compound (C) is different from compounds (A) and (B). The compound (C) is preferably selected from: respiratory chain inhibitors in complex I or II selected from the group consisting of (2001) benzovindiflupyr, (2002) bixafen, (2003) boscalid, (2004) carboxin, (2005) fluopyram, (2006) flutolanil, 237470 1336027 of 49 (2007) fluxapyroxad, (2008) furametpir, (2009) isofetamid, (2010) isopyrazam (1R,4S,9S anti-epimeric enantiomer), (2011) isopyrazam (1S,4R,9R anti-epimeric enantiomer), (2012) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2013) isopyrazam (sinepimeric racemate mixture 1RS. sinepimérico 1RS,4SR,9RS), (2.017) penflufen, (2.018) pentiopirad, (2.019) pidiflumetofen, (2.020) Piraziflumid, (2.021) sedaxano, (2.022) 1,3-diimetil-N-(1,1,3-trimetil-2,3-dihidro-1H-inden-4-il)-1Hpirazol-4-carboxamida, (2.023) 1,3-diimetil-N-[(3R)-1,1,3-trimetil-2,3-dihidro-1H-inden-4-il]-1H-pirazol4-carboxamida, (2.024) 1,3-dimetil-N-[(3S)-1,1,3-trimetil-2,3-dihidro-1H-inden-4-il]-1H-pirazol-4carboxamida, (2.025) 1-methyl-3-(trifluorometil)-N-[2'-(trifluorometil)bifenil-2-il]-1H-pirazol-4carboxamida, (2.026) 2-fluoro-6-(trifluorometil)-N-(1,1,3-trimetil-2,3-dihidro-1H-inden-4-il)benzamida, (2.027) inpirfluxam, (2.028) 3-(difluorometil)-1-metil-N-(1,1,3-trimetil-2,3-dihidro-1H-inden-4-il)-1Hpirazol-4-carboxamida, (2.029) 3 -(difluorometil)-1 -metil-N-[(3 S)-1,1,3-trimetil-2,3-dihidro-1H-inden-4- il] - 1H-pirazol-4-carboxamida, (2.03 0) 3 -(difluorometil)-N-(7 -fluoro- 1,1,3-trimetil-2,3-dihidro-1H-inden-4il)-1-metil-1H-pirazol-4-carboxamida (nombre común: fluindapir), (2.031) 3-(difluorometil)-N-[(3R)-7fluoro-1,1,3-trimetil-2,3-dihidro-1H-inden-4-il]-1-metil-1H-pirazol-4-carboxamida, (2.032) 3- (difluorometil)-N-[(3 S)-7-fluoro-1,1,3-trimetil-2,3-dihidro-1H-inden-4-il] -1 -metil-1H-pirazol-4carboxamida, (2.033) 5,8-difluoro-N-[2-(2-fluoro-4-{ [4-(trifluorometil)piridin-2il]oxi}fenil)etil]quinazolin-4-amina, (2.034) N-(2-ciclopentil-5-fluorobencil)-N-ciclopropil-3(difluorometil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.035) N-(2-terc-butil-5-metilbencil)-Nciclopropil-3 -(difluorometil)-5 -fluoro-1 -metil- 1H-pirazol-4-carboxamida, (2.03 6) N-(2-terc-butilbencil)-Nciclopropil-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.037) N-(5-cloro-2-etilbencil)N-ciclopropil-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.039) N-[(1R,4S)-9(diclorometileno)- 1,2,3,4-tetrahidro- 1,4-metanonaftalen-5-il] -3 -(difluorometil)-1 -metil-1H-pirazol-4carboxamida, (2.040) N-[(1 S,4R)-9-(diclorometileno)-1,2,3,4-tetrahidro-1,4-metanonaftalen-5-il] -3 (difluorometil)-1 -metil- 1H-pirazol-4-carboxamida, (2.041) N-[1 -(2,4-diclorofenil)-1 -metoxipropan-2-il] -3 (difluorometil)-1-metil-1H-pirazol-4-carboxamida, (2.042) N-[2-cloro-6-(trifluorometil)bencil]-Nciclopropil-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.043) N-[3-cloro-2-fluoro-6(trifluorometil)bencil]-N-ciclopropil-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.044) N-[5-cloro-2-(trifluorometil)bencil]-N-ciclopropil-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4carboxamida, (2.045) N-ciclopropil-3-(difluorometil)-5-fluoro-1-metil-N-[5-metil-2-(trifluorometil)bencil]1H-pirazol-4-carboxamida, (2.046) N-ciclopropil-3-(difluorometil)-5-fluoro-N-(2-fluoro-6isopropilbencil)-1-metil-1H-pirazol-4-carboxamida, (2.047) N-ciclopropil-3-(difluorometil)-5-fluoro-N-(2isopropil-5-metilbencil)-1-metil-1H-pirazol-4-carboxamida, (2.048) N-ciclopropil-3-(difluorometil)-5fluoro-N-(2-isopropilbencil)-1-metil-1H-pirazol-4-carbotioamida, (2.049) N-ciclopropil-3-(difluorometil)5-fluoro-N-(2-isopropilbencil)-1-metil-1H-pirazol-4-carboxamida, (2.050) N-ciclopropil-3-(difluorometil)5-fluoro-N-(5-fluoro-2-isopropilbencil)-1-metil-1H-pirazol-4-carboxamida, (2.051) N-ciclopropil-3(difluorometil)-N-(2-etil-4,5-dimetilbencil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.052) N4. 237470 1336027 de 49 ciclopropil-3-(difluorometil)-N-(2-etil-5-fluorobencil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.053) N-ciclopropil-3-(difluorometil)-N-(2-etil-5-metilbencil)-5-fluoro-1-metil-1H-pirazol-4-carboxamida, (2.054) N-ciclopropil-N-(2-ciclopropil-5-fluorobencil)-3-(difluorometil)-5-fluoro-1-metil-1H-pirazol-4carboxamida, (2.055) N-ciclopropil-N-(2-ciclopropil-5-metilbencil)-3-(difluorometil)-5-fluoro-1-metil-1Hpirazol-4-carboxamida, y (2.056) N-ciclopropil-N-(2-ciclopropilbencil)-3-(difluorometil)-5-fluoro-1-metil1H-pirazol-4-carboxamida, (2.057) pyrapropoyne, (2.058) N-[rac-(1S,2S)-2-(2,4-diclorofenil)ciclobutil]-2(trifluorometil)nicotinamida, (2.059) N-[(1S,2S)-2-(2,4-diclorofenil)ciclobutil]-2(trifluorometil)nicotinamida y (2.060) ciclobutrifluram. Con mayor preferencia, el Compuesto (C) se selecciona entre: (2,001) benzovindiflupir, (2,002) bixafen, (2,003) boscalid, (2,005) fluopyram, (2,007) fluxapiroxad, (2,009) isofetamide, (2,010) isopirazam (1R,4S,9S anti-epimeric enantiomer), (2,011) isopirazam (1S,4R,9R anti-epimeric enantiomer), (2,012) isopirazam (1RS,4SR,9SR anti-epimeric racemate), (2,013) isopirazam (mixture of 1RS,4SR,9RS synepimeric racemate and anti-epimeric racemate 1RS,4SR,9SR), (2,014) isopyrazam (synepimeric enantiomer 1R,4S,9R), (2,015) isopyrazam (synepimeric enantiomer). 1S,4R,9S), (2,016) isopyrazam (synepimeric racemate 1RS,4SR,9RS), (2,017) penflufen, (2,018) pentiopyrade, (2,019) pidiflumethofen, (2,021) sedaxane, (2,027) inpirfluxam, (2,030); fluindapyr and (2,060) cyclobutrifluram. Still more preferably, Compound (C) is selected from: (2,001) benzovindiflupyr, (2,002) bixafen, (2,005) fluopyram, (2,007) fluxapyroxad, (2,017) penflufen, (2,018) penthiopyrad, (2,019) pidiflumetofen, (2,021) sedaxane, (2,027) inpirfluxam, (2,030) fluindapir and (2,060) cyclobutrifluram. Even more preferentially, Compound (C) is selected from: (2,002) bixafen, (2,005) fluopyram, (2,007) fluxapyroxad, (2,017) penflufen, (2,019) pidiflumetofen, (2,021) sedaxane, (2,027) inpirfluxam and (2,060) cyclobutrifluram. Even more preferentially, Compound (C) is selected from: (2.002) bixafen, (2.005) fluopyram, (2.017) penflufen, (2.019) pidiflumetofen and (2.027) inpirfluxam. Furthermore, Compound (C) is selected from: (2.005) fluopyram, (2.019) pidiflumetofen and (2.060) cyclobutrifluram. The compound combinations according to the invention may comprise 1, 2, or even more compounds (C). Preferably, the compound combinations according to the invention comprise 1 or 2 compounds (C), more preferably only 1 compound (C). 237470 1336027 of 49 The preferred compound combinations are selected from group (T1-1) which consists of the following mixtures: (I-1) + (II) + (2.001), (I-1) + (II) + (2.002), (I-1) + (II) + (2.003), (I-1) + (II) + (2.004), (I-1) + (II) + (2.005), (I-1) + (II) + (2.006), (I-1) + (II) + (2.007), (I-1) + (II) + (2.008), (I-1) + (II) + (2.009), (I-1) + (II) + (2.010), (I-1) + (II) + (2.011), (I-1) + (II) + (2.012), (I-1) + (II) + (2.013), (I-1) + (II) + (2.014), (I-1) + (II) + (2.015), (I-1) + (II) + (2.016), (I-1) + (II) + (2.017), (I-1) + (II) + (2.018), (I-1) + (II) + (2.019), (I-1) + (II) + (2.020), (I-1) + (II) + (2.021), (I-1) + (II) + (2.022), (I-1) + (II) + (2.023), (I-1) + (II) + (2.024), (I-1) + (II) + (2.025), (I-1) + (II) + (2.026), (I-1) + (II) + (2.027), (I-1) + (II) + (2.028), (I-1) + (II) + (2.029), (I-1) + (II) + (2.030), (I-1) + (II) + (2.031), (I-1) + (II) + (2.032), (I-1) + (II) + (2.033), (I-1) + (II) + (2.034), (I-1) + (II) + (2.035), (I-1) + (II) + (2.036), (I-1) + (II) + (2.037), (I-1) + (II) + (2.039), (I-1) + (II) + (2.040), (I-1) + (II) + (2.041), (I-1) + (II) + (2.042), (I-1) + (II) + (2,043), (I-1) + (II) + (2,044), (I-1) + (II) + (2,045), (I-1) + (II) + (2,046), (I-1) + (II) + (2,047), (I-1) + (II) + (2,048), (I-1) + (II) + (2,049), (I-1) + (II) + (2,050), (I-1) + (II) + (2,051), (I-1) + (II) + (2,052), (I-1) + (II) + (2,053), (I-1) + (II) + (2,054), (I-1) + (II) + (2,055), (I-1) + (II) + (2,056), (I-1) + (II) + (2,057), (I-1) + (II) + (2,058), (I-1) + (II) + (2,059), (I-1) + (II) + (2,060). The preferred compound combinations are also selected from group (T1-2) which consists of the following mixtures: (I-2) + (II) + (2.001), (I-2) + (II) + (2.002), (I-2) + (II) + (2.003), (I-2) + (II) + (2.004), (I-2) + (II) + (2.005), (I-2) + (II) + (2.006), (I-2) + (II) + (2.007), (I-2) + (II) + (2.008), (I-2) + (II) + (2.009), (I-2) + (II) + (2.010), (I-2) + (II) + (2.011), (I-2) + (II) + (2.012), (I-2) + (II) + (2.013), (I-2) + (II) + (2.014), (I-2) + (II) + (2.015), (I-2) + (II) + (2.016), (I-2) + (II) + (2.017), (I-2) + (II) + (2.018), (I-2) + (II) + (2.019), (I-2) + (II) + (2.020), (I-2) + (II) + (2.021), (I-2) + (II) + (2.022), (I-2) + (II) + (2.023), (I-2) + (II) + (2.024), (I-2) + (II) + (2.025), (I-2) + (II) + (2.026), (I-2) + (II) + (2.027), (I-2) + (II) + (2.028), (I-2) + (II) + (2.029), (I-2) + (II) + (2.030), (I-2) + (II) + (2.031), (I-2) + (II) + (2.032), (I-2) + (II) + (2.033), (I-2) + (II) + (2.034), (I-2) + (II) + (2.035), (I-2) + (II) + (2.036), (I-2) + (II) + (2.037), (I-2) + (II) + (2.039), (I-2) + (II) + (2.040), (I-2) + (II) + (2.041), (I-2) + (II) + (2.042) (2,049), (I-2) + (II) + (2,050), (I-2) + (II) + (2,051), (I-2) + (II) + (2,052), (I-2) + (II) + (2,053), (I-2) + (II) + (2,054), (I-2) + (II) + (2,055), (I-2) + (II) + (2,056), (I-2) + (II) + (2,057), (I-2) + (II) + (2,058), (I-2) + (II) + (2,059), (I-2) + (II) + (2,060). The preferred compound combinations are also selected from group (T1-3) which consists of the following mixtures: (I-1) + (I-2) + (II) + (2.001), (I-1) + (I-2) + (II) + (2.002), (I-1) + (I-2) + (II) + (2.003), (I-1) + (I-2) + (II) + (2.004), (I-1) + (I-2) + (II) + (2.005), (I-1) + (I-2) + (II) + (2.006), (I-1) + (I-2) + (II) + (2.007), (I-1) + (I-2) + (II) + (2.008), (I-1) + (I-2) + (II) + (2.009), (I-1) + (I-2) + (II) + (2.010), (I-1) + (I-2) + (II) + (2.011), (I-1) + (I-2) + (II) + (2.012), (I-1) + (I-2) + (II) + (2.013), (I-1) + (I-2) + (II) + (2.014), (I-1) + (I-2) + (II) + (2.015), (I-1) + (I-2) + (II) + (2.016), (I-1) + (I-2) + (II) + (2.017), (I-1) + (I-2) + (II) + (2.018), (I-1) + (I-2) + (II) + 237470 1336027 de 49 (2.019), (I-1) + (I-2) + (II) + (2.020), (I-1) + (I-2) + (II) + (2.021), (I-1) + (I-2) + (II) + (2.022), (I-1) + (I-2) + (II) + (2.023), (I-1) + (I-2) + (II) + (2.024), (I-1) + (I-2) + (II) + (2.025), (I-1) + (I-2) + (II) + (2.026), (I-1) + (I-2) + (II) + (2.027), (I-1) + (I-2) + (II) + (2.028), (I-1) + (I-2) + (II) + (2.029), (I-1) + (I-2) + (II) + (2.030), (I-1) + (I-2) + (II) + (2.031), (I-1) + (I-2) + (II) + (2.032), (I-1) + (I-2) + (II) + (2.033), (I-1) + (I-2) + (II) + (2.034), (I-1) + (I-2) + (II) + (2.035), (I-1) + (I-2) + (II) + (2.036), (I-1) + (I-2) + (II) + (2.037), (I-1) + (I-2) + (II) + (2.039), (I-1) + (I-2) + (II) + (2.040), (I-1) + (I-2) + (II) + (2.041), (I-1) + (I-2) + (II) + (2.042), (I-1) + (I-2) + (II) + (2.043), (I-1) + (I-2) + (II) + (2.044), (I-1) + (I-2) + (II) + (2.045), (I-1) + (I-2) + (II) + (2.046), (I-1) + (I-2) + (II) + (2.047), (I-1) + (I-2) + (II) + (2.048), (I-1) + (I-2) + (II) + (2.049), (I-1) + (I-2) + (II) + (2.050), (I-1) + (I-2) + (II) + (2.051), (I-1) + (I-2) + (II) + (2.052), (I-1) + (I-2) + (II) + (2.053), (I-1) + (I-2) + (II) + (2.054), (I-1) + (I-2) + (II) + (2.055), (I-1) + (I-2) + (II) + (2.056), (I-1) + (I-2) + (II) + (2.057), (I-1) + (I-2) + (II) + (2.058), (I-1) + (I-2) + (II) + (2.059), (I-1) + (I-2) + (II) + (2.060). In combinations according to the invention comprising a mixture of (I-1) and (I-2), and in particular in mixtures of group (T1-3), the compounds (I-1) and (I-2) can be present in a wide range of effective weight ratios of (I-1) : (I-2), for example in a range of 100,000:1 to 1:100, preferably in a weight ratio of 100:1 to 1:100, more preferably in a weight ratio of 50:1 to 1:50, and even more preferably in a weight ratio of 20:1 to 1:20. Other ratios of (I-1) : (I-2) that may be used according to the present invention, with greater preference in the order expressed, are: 95:1 to 1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45, 40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 to 1:10, 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3, 2:1 to 1:2. Other ratios of (I-1) : (I-2) that can be used according to the present invention are: 95:1 to 1:1, 90:1 to 1:1, 85:1 to 1:1, 80:1 to 1:1, 75:1 to 1:1, 70:1 to 1:1, 65:1 to 1:1, 60:1 to 1:1, 55:1 to 1:1, 45:1 to 1:1, 40:1 to 1:1, 35:1 to 1:1, 30:1 to 1:1, 25:1 to 1:1, 15:1 to 1:1, 10:1 to 1:1, 5:1 to 1:1, 4:1 to 1:1, 3:1 to 1:1, 2:1 to 1:1. Other ratios of (I-1) : (I-2) that may be used according to the present invention are: 1:1 to 1:95, 1:1 to 1:90, 1:1 to 1:85, 1:1 to 1:80, 1:1 to 1:75, 1:1 to 1:70, 1:1 to 1:65, 1:1 to 1:60, 1:1 to 1:55, 1:1 to 1:45, 1:1 to 1:40, 1:1 to 1:35, 1:1 to 1:30, 1:1 to 1:25, 1:1 to 1:15, 1:1 to 1:10, 1:1 to 1:5, 1:1 to 1:4, 1:1 to 1:3, 1:1 to 1:2. The most preferred compound combinations are selected from group (T1-1A) which consists of the following mixtures: (I-1) + (II) + (2,001), (I-1) + (II) + (2,002), (I-1) + (II) + (2,003), (I-1) + (II) + (2,005), (I-1) + (II) + (2,007), (I-1) + (II) + (2,009), (I-1) + (II) + (2010), (I-1) + (II) + (2011), (I-1) + (II) + (2012), (I-1) + (II) + (2013), (I-1) + (II) + (2014), (I-1) + (II) + (2015), (I-1) + (II) + (2016), (I-1) + (II) + (2,017), (I-1) + (II) + (2,018), (I-1) + (II) + (2,019), (I-1) + (II) + (2,021), (I-1) + (II) + (2,027), (I-1) + (II) + (2,030), (I-1) + (II) + (2,060). The most preferred compound combinations are also selected from group (T1-2A) which consists of the following mixtures: 237470 1336027 of 49 (I-2) + (II) + (2,001), (I-2) + (II) + (2,002), (I-2) + (II) + (2,003), (I-2) + (II) + (2,005), (I-2) + (II) + (2,007), (I-2) + (II) + (2,009), (I-2) + (II) + (2.010), (I-2) + (II) + (2.011), (I-2) + (II) + (2.012), (I-2) + (II) + (2.013), (I-2) + (II) + (2.014), (I-2) + (II) + (2.015), (I-2) + (II) + (2.016), (I-2) + (II) + (2.017), (I-2) + (II) + (2.018), (I-2) + (II) + (2.019), (I-2) + (II) + (2.021), (I-2) + (II) + (2.027), (I-2) + (II) + (2.030), (I-2) + (II) + (2.060). Even more preferred compound combinations are selected from group (T1-1B) which consists of the following mixtures: (I-1) + (II) + (2,001), (I-1) + (II) + (2,002), (I-1) + (II) + (2,005), (I-1) + (II) + (2,007), (I-1) + (II) + (2,017), (I-1) + (II) + (2,018), (I-1) + (II) + (2.019), (I-1) + (II) + (2.021), (I-1) + (II) + (2.027), (I-1) + (II) + (2.030), (I-1) + (II) + (2.060). Even more preferred compound combinations are also selected from group (T1-2B) consisting of the following mixtures: (I-2) + (II) + (2,001), (I-2) + (II) + (2,002), (I-2) + (II) + (2,005), (I-2) + (II) + (2,007), (I-2) + (II) + (2,017), (I-2) + (II) + (2,018), (I-2) + (II) + (2.019), (I-2) + (II) + (2.021), (I-2) + (II) + (2.027), (I-2) + (II) + (2.030), (I-2) + (II) + (2.060). Even higher preference compound combinations are selected from group (T1-1C) which consists of the following combinations: (I-1) + (II) + (2.002), (I-1) + (II) + (2.005), (I-1) + (II) + (2.017), (I-1) + (II) + (2.019), (I-1) + (II) + (2.027). Even more preferred compound combinations are also selected from group (T1-2C) consisting of the following combinations: (I-2) + (II) + (2.002), (I-2) + (II) + (2.005), (I-2) + (II) + (2.017), (I-2) + (II) + (2.019), (I-2) + (II) + (2.027). Even higher preference compound combinations are selected from group (T1-1D) which consists of the following combinations: (I-1) + (II) + (2.005), (I-1) + (II) + (2.019), (I-1) + (II) + (2.060). Even more preferred compound combinations are also selected from group (T1-2C) consisting of the following combinations: (I-2) + (II) + (2.005), (I-2) + (II) + (2.019), (I-2) + (II) + (2.060). The combinations of compounds that enjoy the highest preference are selected from group (T1-1D). In the combinations according to the invention, compounds (A) and (B) can be present in a wide range of effective weight ratios of A:B, for example in a range of 1000:1 to 1:1000, 750:1 to 237470 1336027 of 49 1:750, 500:1 to 1:500, 400:1 to 1:400, 300:1 to 1:300, 250:1 to 1:250, 200:1 to 1:200, 150:1 to 1:150, 100:1 to 1:100, preferably in a weight ratio of 50:1 to 1:50, even more preferably in a weight ratio of 20:1 to 1:20. Other A:B ratios that may be used according to the present invention, in the order expressed, are: 95:1 to 1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45, 40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 to 1:10, 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3, 2:1 to 1:2. Other A:B ratios that can be used according to the present invention are: 1000:1 to 1:1, 750:1 to 1:1, 500:1 to 1:1, 250:1 to 1:1, 95:1 to 1:1, 90:1 to 1:1, 85:1 to 1:1, 80:1 to 1:1, 75:1 to 1:1, 70:1 to 1:1, 65:1 to 1:1, 60:1 to 1:1, 55:1 to 1:1, 45:1 to 1:1, 40:1 to 1:1, 35:1 to 1:1, 30:1 to 1:1, 25:1 to 1:1, 15:1 to 1:1, 10:1 to 1:1, 5:1 to 1:1, 4:1 to 1:1, 3:1 to 1:1, 2:1 to 1:1. Other A:B ratios that can be used according to the present invention are: 1:1 to 1:1000, 1:1 to 1:750, 1:1 to 1:500, 1:1 to 1:250, 1:1 to 1:95, 1:1 to 1:90, 1:1 to 1:85, 1:1 to 1:80, 1:1 to 1:75, 1:1 to 1:70, 1:1 to 1:65, 1:1 to 1:60, 1:1 to 1:55, 1:1 to 1:45, 1:1 to 1:40, 1:1 to 1:35, 1:1 to 1:30, 1:1 to 1:25, 1:1 to 1:15, 1:1 to 1:10, 1:1 to 1:5, 1:1 to 1:4, 1:1 to 1:3, 1:1 to 1:2. In the combinations according to the invention, compounds (A) and (C) can be present in a wide range of effective weight ratios of A:C, for example in a range of 1000:1 to 1:1000, 750:1 to 1:750, 500:1 to 1:500, 400:1 to 1:400, 300:1 to 1:300, 250:1 to 1:250, 200:1 to 1:200, 150:1 to 1:150, 100:1 to 1:100, preferably in a weight ratio of 50:1 to 1:50, even more preferably in a weight ratio of 20:1 to 1:20. Other A:C ratios that may be used according to the present invention, in the order expressed, are: 95:1 to 1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45, 40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 to 1:10, 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3, 2:1 to 1:2. Other A:C ratios that can be used according to the present invention are: 1000:1 to 1:1, 750:1 to 1:1, 500:1 to 1:1, 250:1 to 1:1, 95:1 to 1:1, 90:1 to 1:1, 85:1 to 1:1, 80:1 to 1:1, 75:1 to 1:1, 70:1 to 1:1, 65:1 to 1:1, 60:1 to 1:1, 55:1 to 1:1, 45:1 to 1:1, 40:1 to 1:1, 35:1 to 1:1, 30:1 to 1:1, 25:1 to 1:1, 15:1 to 1:1, 10:1 to 1:1, 5:1 to 1:1, 4:1 to 1:1, 3:1 to 1:1, 2:1 to 1:1. Other A:C ratios that can be used according to the present invention are: 1:1 to 1:1000, 1:1 to 1:750, 1:1 to 1:500, 1:1 to 1:250, 1:1 to 1:95, 1:1 to 1:90, 1:1 to 1:85, 1:1 to 1:80, 1:1 to 1:75, 1:1 to 1:70, 1:1 to 1:65, 1:1 to 1:60, 1:1 to 1:55, 1:1 to 1:45, 1:1 to 1:40, 1:1 to 1:35, 1:1 to 1:30, 1:1 to 1:25, 1:1 to 1:15, 1:1 to 1:10, 1:1 to 1:5, 1:1 to 1:4, 1:1 to 1:3, 1:1 to 1:2. In the combinations according to the invention, compounds (B) and (C) can also be present in a wide range of effective B:C weight ratios. The respective weight ratio is automatically derived from the chosen A:B and A:C weight ratios. 237470 1336027 of 49 If more than one, for example 2 or 3, compounds (C) are present, the weight ratios refer to the total amount of compound (C), that is, the sum of the amount of each compound (C) present in the combination. The same applies mutatis mutandis in the case of two compounds (A) being present, that is, a mixture of (I-1) and (I-2). Isomers As mentioned, compounds (I-1) and (I-2) may be present in the form of different stereoisomers. Depending on the nature of the substituents of compounds (B) and (C), compounds (B) and (C) may also be present in the compound combinations of the invention in the form of different stereoisomers. These stereoisomers are, for example, enantiomers, diastereomers, atropisomers, or geometric isomers. Consequently, the invention encompasses both pure stereoisomers and any mixture of these isomers. When a compound may be present in two or more equilibrium tautomeric forms, a reference to the compound by means of a tautomeric description shall be considered to include all tautomeric forms.When a compound can be present in isomeric and / or tautomeric forms, it is understood that said compound includes, where applicable, the corresponding isomeric and / or tautomeric forms or mixtures thereof, even when these are not specifically mentioned in each case. N-Oxide Salts Depending on the nature of the substituents, the compounds present in the compound combinations of the invention may be present in the form of the free compound and / or a solvate and / or an agrochemically active salt and / or an N-oxide thereof. Agrochemically active salts include acid addition salts of organic and inorganic acids, as well as salts of common bases. Examples of inorganic acids are hydrohalic acids, such as hydrogen fluoride, hydrogen chloride, hydrogen bromide, and hydrogen iodide, sulfuric acid, phosphoric acid, and nitric acid, and acid salts, such as sodium bisulfate and potassium bisulfate. Useful organic acids include, for example, formic acid, carbonic acid, and alkanoic acids such as acetic acid, trifluoroacetic acid, trichloroacetic acid, and propionic acid, and also glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid, oxalic acid, saturated or monounsaturated or diunsaturated fatty acids of 6 to 20 carbon atoms, alkylsulfuric monoesters, alkylsulfonic acids (sulfonic acids with linear or branched chain alkyl radicals of 1 to 20 carbon atoms),arylsulfonic acids or aryldisulfonic acids (aromatic radicals, such as phenyl and naphthyl, having one or two sulfonic acid groups), alkylphosphonic acids (phosphonic acids having linear or branched chain alkyl radicals of 1 to 20 carbon atoms), arylphosphonic acids or aryldiphosphonic acids (aromatic radicals, such as phenyl and naphthyl, having one or two phosphonic acid radicals), where the radicals, 237470 1336027 of 49 alkyl and aryl can have other substituents, for example p-toluenesulfonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid. The solvates of the compounds present in the combinations of compounds of the invention or their salts are stoichiometric compositions of the compounds with solvents. The N-oxides of the compounds present in the combination of compounds of the invention or their intermediates can be easily obtained by ordinary processes, for example by N-oxidation with hydrogen peroxide (H2O2), peracids, for example peroxysulfuric acid or peroxycarboxylic acids, such as meta-chloroperoxybenzoic acid or peroxymonosulfuric acid (Caro's acid). For example, the corresponding N-oxides can be prepared from the respective compounds using conventional oxidation methods, e.g., by treating the compounds with an organic peracid such as metachloroperbenzoic acid (e.g., WO-A 2003 / 64572 or J. Med. Chem. 38 (11), 1892-1903, 1995); or with inorganic oxidizing agents such as hydrogen peroxide (e.g., J. Heterocyc. Chem. 18 (7), 1305-1308, 1981) or oxone (e.g., J. Am. Chem. Soc. 123 (25), 5962-5973, 2001). Oxidation may yield either pure mono-N-oxides or a mixture of different N-oxides, which can be separated by conventional methods such as chromatography. Crystalline form The compounds present in the compound combinations of the invention may exist in multiple crystalline and / or amorphous forms. The crystalline forms include non-solvated crystal forms, solvates, and hydrates. Formulations The present invention also relates to compositions for controlling unwanted microorganisms, comprising a combination of compounds according to the invention. The compositions can be applied to the microorganisms and / or their habitat. The composition comprises a combination of compounds of the invention and at least one agriculturally suitable auxiliary, for example, one or more carriers and / or surfactants. A carrier is a solid or liquid substance, natural or synthetic, organic or inorganic, that is generally inert. The carrier typically enhances the application of active compounds, for example, to plants, plant parts, or seeds. Examples of suitable solid carriers include, but are not limited to, ammonium salts, natural rock flours such as kaolin, clays, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth, silica gel, and synthetic rock flours such as finely divided silica, alumina, and silicates. Examples of solid carriers typically useful for preparing granules include, but are not limited to, crushed and fractionated natural rocks such as calcite, marble, and stone. 237470 1336027 of 49 pumice, sepiolite and dolomite, synthetic granules of inorganic and organic flours and granules of organic material such as paper, sawdust, coconut husks, corn cobs and tobacco stalks. Examples of suitable liquid carriers include, but are not limited to, water, organic solvents and combinations thereof.Examples of suitable solvents include polar and nonpolar organic chemical liquids, for example from the classes of aromatic and non-aromatic hydrocarbons (such as cyclohexane, paraffins, alkylbenzenes, xylene, toluene, alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride), alcohols and polyols (which may optionally also be substituted, etherified and / or esterified, such as butanol or glycol), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone, or cyclohexanone), esters (including fats and oils) and (poly) ethers, substituted and unsubstituted amines, amides (such as dimethylformamide), lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (as dimethyl sulfoxide).The carrier can also be a liquefied gaseous diluent, that is, a liquid that is gaseous at standard temperature and under standard pressure, for example, aerosol propellants such as halohydrocarbons, butane, propane, nitrogen, and carbon dioxide. The amount of carrier typically ranges from 1 to 99.99%, preferably from 5 to 99.9%, with a higher preference for 10 to 99.5%, and with an even higher preference for 20 to 99% by weight of the composition. The surfactant can be an ionic surfactant (cationic or anionic), or a non-ionic surfactant, such as one or more ionic or non-ionic emulsifiers, one or more foam formers, one or more dispersants, one or more wetting agents, and any mixture thereof.Examples of suitable surfactants include, but are not limited to, polyacrylic acid salts, lignosulfonic acid salts, phenolsulfonic acid or naphthalenesulfonic acid salts, polycondensation of ethylene oxide and / or propylene oxide with fatty alcohols, fatty acids or fatty amines (polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, e.g., alkylaryl polyglycol ethers), substituted phenols (preferably alkylphenols or arylphenols), sulfosuccinic ester salts, taurine derivatives (preferably alkyl taurates), phosphoric esters of polyethoxylated alcohols or phenols, fatty esters of polyols and derivatives of compounds containing sulfates, sulfonates, phosphates (e.g., alkylsulfonates, alkylsulfates, arylsulfonates) and protein hydrolysates, lignosulfite residual liquors and methylcellulose.A surfactant is typically used when a compound in the combination of compounds of the invention and / or the carrier is insoluble in water and the application is carried out with water. If present, the amount of surfactant typically ranges from 5 to 40% by weight based on the total weight of the composition. Other examples of suitable auxiliaries include water repellents, driers, and binders (adhesive, tackifying agent, fixing agent, such as carboxymethylcellulose, natural and synthetic polymers in the form of powders, granules, or matrices, such as gum arabic, polyvinyl alcohol, and polyvinyl acetate, natural phospholipids such as cephalins and lecithins, and synthetic phospholipids such as polyvinylpyrrolidone and tylose), thickeners, stabilizers (e.g., chilling stabilizers, preservatives, antioxidants, light stabilizers, or other agents that may improve chemical and / or physical stability), dyes, or pigments (such as inorganic pigments, e.g., iron oxide, titanium oxide, and Prussian blue; organic dyes, for example, 237470 1336027 of 49 example alizarin, azo and metallic phthalocyanine dyes), antifoaming agents (e.g. silicone and magnesium stearate antifoaming agents), preservatives (e.g. dichlorophene and benzyl hemiformal alcohol), secondary thickeners (cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clays and finely divided silica), adhesives, gibberellins and processing aids, mineral and vegetable oils, perfumes, waxes, nutrients (including trace elements such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc), protective colloids, toxitropic substances, penetrants, sequestering agents and complexing agents. The choice of auxiliaries depends on the intended application of the combination of compounds of the invention and / or their physical properties. Furthermore, auxiliaries can be selected to impart particular properties (technical, physical, and / or biological properties) to the formulations / compositions or forms of use prepared from them. The choice of auxiliaries can allow for the customization of formulations to specific needs. The composition may be presented in any conventional form, such as solutions (e.g., aqueous solutions), emulsions, wettable powders, water-oil suspensions, powders, ash, pastes, soluble powders, soluble granules, broadcast granules, suspension-emulsion concentrates, natural or synthetic products impregnated with the combination of compounds of the invention, fertilizers, and also microencapsulations in polymeric substances. The combination of compounds of the invention may be present in suspended, emulsified, or dissolved form. The formulations mentioned can be prepared in a known way per se, for example by mixing the active ingredients with at least one auxiliary. The composition can be provided to the end user "ready to use," meaning it can be applied directly to plants or seeds using a suitable device, such as a sprayer or duster. Alternatively, the composition can be provided to the end user as concentrates that must be diluted before use, preferably with water. The formulations generally contain between 0.01 and 99% by weight, between 0.05 and 98% by weight, preferably between 0.1 and 95% by weight, more preferably between 0.5 and 90%, and most preferably between 1 and 80% by weight of the combination of compounds of the present invention. If the composition comprises two or more active ingredients, the ranges indicated refer to the total amount of the combination of compounds of the present invention. The formulations described above can be used to control unwanted microorganisms by applying them to the microorganisms and / or in their habitat. In one specific embodiment of the invention, the combination of compounds is provided in a sprayable form to allow application by spraying. In this embodiment, the 237470 1336027 of 49 combination of compounds according to the invention is provided as a composition / formulation, comprising the active ingredients and at least one suitable liquid carrier. Suitable liquid carriers are preferably selected from water, organic solvents, and combinations thereof. Most preferably, the liquid carrier is water or a mixture of water and an organic solvent. The preferred suitable organic solvents are those described above. The amount of liquid carrier generally ranges from 1 to 99.99%, preferably from 5 to 99.9%, with the highest preference being from 10 to 99.5%, and with the highest preference being from 20 to 99% by weight of the composition. Preferably, the sprayable composition further comprises at least one surfactant. Suitable surfactants are those described above. It may also comprise at least one additional auxiliary as described. Preferably, the sprayable composition is provided as an emulsifiable concentrate or a suspension concentrate, more preferably an emulsifiable concentrate comprising the active ingredients in a total amount of 20 to 400 g / L, preferably 40 to 200 g / L, or a suspension concentrate comprising the active ingredients in a total amount of 50 to 500 g / L, preferably 100 to 400 g / L. The preparation of such concentrates is well known to those skilled in the art. For example, emulsifiable concentrates (ECs) can be prepared by dissolving the desired amount of active ingredients, for example, 20 to 400 g per liter of concentrate and 50 to 100 g per liter of concentrate of at least one surfactant, in a water-insoluble organic solvent, for example, an aromatic hydrocarbon, or a water-soluble organic solvent, for example, N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), or γ-butyrolactone. Suspension concentrates (SCs) can be prepared by mixing the desired amount of active ingredients, for example, 50 to 500 g per liter of concentrate, 20 to 100 g per liter of concentrate of at least one surfactant, and 1 to 20 g per liter of concentrate of at least one binder and / or secondary thickener, and suspending this mixture in water. Preferably, before applying these concentrates to the plant or a part thereof, the concentrate is diluted with water. More preferably, the emulsifiable concentrate or the suspension concentrate is mixed with water in such quantity as to achieve a total concentration of active ingredients in the resulting mixture of 0.1 to 5 g / L, preferably 0.2 to 2 g / L, and more preferably 0.25 to 1 g / L. Other active ingredients 237470 1336027 of 49 The combinations of compounds according to the invention can be used as such or in compositions / formulations and can be mixed with other known active ingredients, for example bactericides, acaricides, nematicides or insecticides, to broaden, for example, the spectrum of activity or to prevent the development of resistance. Useful compounds that can be mixed with include, for example, insecticides, acaricides, nematicides, and bactericides (see also, Pesticide Manual, 14th ed.). It is also possible to mix it with other known active ingredients, such as herbicides, or with fertilizers and growth regulators, protectants and / or semiochemicals. Examples of biological control agents that can be combined with the compound combinations of the invention are: (A) Selected antibacterial agents from the group of: (A1) bacteria, such as (A1.1) Bacillus subtilis, in particular strain QST713 / AQ713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, US, with Accession No. NRRL B21661 and described in United States Pat. 6,060,051); (A1.2) Bacillus amyloliquefaciens, in particular strain D747 (available as Double Nickel™ from Certis, US, with accession number FERM BP-8234 and disclosed in US Patent No. 7,094,592); (A1.3) Bacillus pumilus, in particular strain BU F-33 (with Accession No. NRRL 50185); (A1.4) Bacillus subtilis var. amyloliquefaciens strain FZB24 (available as Taegro® from Novozymes, US); (A1.5) of Paenibacillus sp. strain with the No. of Access NRRL B-50972 or No. of Access NRRL B-67129 and described in International Patent Publication No. WO 2016 / 154297; and (A2) fungi, such as (A2.1) Aureobasidium pullulans, in particular blastospores of strain DSM14940; (A2.2) Aureobasidium pullulans blastospores of strain DSM 14941; (A2.3) Aureobasidium pullulans, in particular mixtures of blastospores of strains DSM14940 and DSM14941; (B) Biological fungicides selected from the group of: (B1) bacteria, for example (B1.1) Bacillus subtilis, in particular strain QST713 / AQ713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, US, with NRRL Accession No. B21661 and described in U.S. Patent No. 6,060,051); (B1.2) Bacillus pumilus, in particular strain QST2808 (available as SONATA® from Bayer CropScience LP, US, with NRRL Accession No. B-30087 and described in U.S. Patent No. 6,245,551); (B1.3) Bacillus pumilus, in particular strain GB34 (available as Yield Shield® from Bayer AG, DE); (B1.4) Bacillus pumilus, in particular strain BU F-33 (with Accession No. NRRL 50185); (B1.5) Bacillus amyloliquefaciens, in particular strain D747 (available as Double Nickel™ from Certis, US, with accession number FERM BP-8234 and disclosed in U.S. Patent No. 7,094,592); (B1.6) 237470 1336027 of 49 Bacillus subtilis Y1336 (available as BIOBAC® WP from Bion-Tech, Taiwan, registered as a biological fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and 5277); (B1.7) Bacillus amyloliquefaciens strain MBI 600 (available as SUBTILEX from BASF SE); (B1.8) Bacillus subtilis strain GB03 (available as Kodiak® from Bayer AG, DE); (B1.9) Bacillus subtilis var. amyloliquefaciens strain FZB24 (marketed by Novozymes Biologicals Inc., Salem, Virginia or Syngenta Crop Protection, LLC, Greensboro, North Carolina as the fungicide TAEGRO® or TAEGRO®ECO (EPA Registration No. 70127-5); (B1.10) Bacillus mycoides, isolate J (available as BmJ TGAI or WG from Certis USA); (B1.11) Bacillus licheniformis, in particular strain SB3086 (available as EcoGuard TM Biofungicide and Green Leaf from Novozymes); (B1.12) a strain of Paenibacillus sp. with NRRL Accession No. B-50972 or NRRL Accession No. B-67129 and described in International Patent Publication No. WO 2016 / 154297. In some embodiments, the biological control agent is a strain of Bacillus subtilis or Bacillus amyloliquefaciens that produces a fengycin- or plipastatin-like compound, an iturin-like compound, and / or a surfactin-like compound. For background information, see the following article: Ongena, M., et al., “Bacillus Lipopeptides: Versatile Weapons for Plant Disease Biocontrol,” Trends in Microbiology, Vol. 16, No. 3, March 2008, pp. 115–125. Bacillus strains capable of producing lipopeptides include Bacillus subtilis QST713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, US, with Accession No. NRRL B21661 and described in US Patent No. 6,060,051), Bacillus amyloliquefaciens strain D747 (available as Double Nickel™ from Certis, US, with accession number FERM BP-8234 and disclosed in US Patent No. 7,094,592); Bacillus subtilis MBI600 (available as SUBTILEX® from Becker Underwood, US Reg. No.EPA 71840-8); Bacillus subtilis Y1336 (available as BIOBAC® WP from Bion-Tech, Taiwan, registered as a biological fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and 5277); Bacillus amyloliquefaciens, in particular strain FZB42 (available as RHIZOVITAL® from ABiTEP, DE); and Bacillus subtilis var. amyloliquefaciens FZB24 (marketed by Novozymes Biologicals Inc., Salem, Virginia or Syngenta Crop Protection, LLC, Greensboro, North Carolina as the fungicide TAEGRO® or TAEGRO® ECO (EPA Registration No. 70127). 5); and (B2) fungi, for example: (B2.1) Coniothyrium minitans, in particular strain CON / M / 91-8 (Accession No. DSM-9660; for example, Contans® from Bayer); (B2.2) Metschnikowia fructicola, in particular strain NRRL Y-30752 (for example, Shemer®); (B2.3) Microsphaeropsis ochracea (for example, Microx® from Prophyta); (B2.5) Trichoderma spp., including Trichoderma atroviride, strain SC1 described in International Application No. PCT / IT2008 / 000196); (B2.6) Trichoderma harzianum rifai strain KRL-AG2 (also known as strain T-22, / ATCC 208479, e.g. PLANTSHIELD T-22G, Rootshield®, and TurfShield from BioWorks, US); (B2.14) Gliocladium roseum, strain 321U from WF Stoneman Company LLC; (B2.35) Talaromyces flavus, strain V117b; (B2.36) Trichoderma asperellum, strain ICC 012 from Isagro; (B2.37) Trichoderma asperellum, strain SKT-1 (e.g. ECO-HOPE® from Kumiai Chemical Industry); (B2.38) Trichoderma atroviride, strain CNCM I-1237 (e.g. Esquive® WP from Agrauxine, 237470 1336027 de 49 FR); (B2.39) Trichoderma atroviride, cepa número V08 / 002387; (B2.40) Trichoderma atroviride, Nro. de cepa NMI V08 / 002388; (B2.41) Trichoderma atroviride, Nro. de cepa NMI V08 / 002389; (B2.42) Trichoderma atroviride, Nro. de cepa NMI V08 / 002390; (B2.43) Trichoderma atroviride, cepa LC52 (por ejemplo Tenet de Agrimm Technologies Limited); (B2.44) Trichoderma atroviride, cepa ATCC 20476 (IMI 206040); (B2.45) Trichoderma atroviride, cepa T11 (IMI352941 / CECT20498); (B2.46) Trichoderma harmatum; (B2.47) Trichoderma harzianum; (B2.48) Trichoderma harzianum rifai T39 (e.g., Trichodex® from Makhteshim, US); (B2.49) Trichoderma harzianum, in particular strain KD (e.g., Trichoplus from Biological Control Products, SA (acquired by Becker Underwood)); (B2.50) Trichoderma harzianum, strain ITEM 908 (e.g., Trianum-P from Koppert); (B2.51) Trichoderma harzianum, strain TH35 (e.g., Root-Pro from Mycontrol); (B2.52) Trichoderma virens (also known as Gliocladium virens), in particular strain GL-21 (e.g., SoilGard 12G from Certis, US); (B2.53) Trichoderma viride, strain TV1 (e.g. Koppert's Trianum-P); (B2.54) Ampelomyces quisqualis, in particular the AQ 10 strain (for example AQ 10® from IntrachemBio Italia); (B2.56) Aureobasidium pullulans, in particular blastospores of strain DSM14940; (B2.57) Aureobasidium pullulans, in particular blastospores of strain DSM 14941; (B2.58) Aureobasidium pullulans, in particular blastospore mixtures of strains DSM14940 and DSM 14941 (e.g., Botector® from bioferm, CH); (B2.64) Cladosporium cladosporioides, strain H39 (from Stichting Dienst Landbouwkundig Onderzoek); (B2.69) Gliocladium catenulatum (Synonym: Clonostachys rosea f catenulate) strain J1446 (e.g., Prestop® from AgBio Inc. and also, e.g., Primastop® from Kemira Agro Oy); (B2.70) Lecanicillium lecanii (formerly known as Verticillium lecanii) conidia of strain KV01 (e.g., Vertalec® from Koppert / Arysta); (B2.71) Penicillium vermiculatum; (B2.72) Pichia anomala, strain WRL-076 (NRRL Y-30842); (B2.75) Trichoderma atroviride, strain SKT-1 (FERM P-16510); (B2.76) Trichoderma atroviride, strain SKT-2 (FERM P-16511); (B2.77) Trichoderma atroviride, strain SKT-3 (FERM P-17021); (B2.78) Trichoderma gamsii (previously T. viride), strain ICC080 (IMI CC 392151 CABI, e.g. BioDerma from AGROBIOSOL DE MEXICO, SA DE CV); (B2.79) Trichoderma harzianum, strain DB 103 (e.g., T-Gro 7456 from Dagutat Biolab); (B2.80) Trichoderma polysporum, strain IMI 206039 (e.g., Binab TF WP from BINAB Bio-Innovation AB, Sweden); (B2.81) Trichoderma stromaticum (e.g., Tricovab from Ceplac, Brazil); (B2.83) Ulocladium oudemansii, in particular strain HRU3 (e.g., Botry-Zen® from Botry-Zen Ltd, NZ); (B2.84) Verticillium alboatrum (formerly V. dahliae), strain WCS850 (CBS 276.92; e.g., Dutch Trig from Tree Care Innovations); (B2.86) Verticillium chlamydosporium; (B2.87) mixtures of Trichoderma asperellum strain ICC 012 and Trichoderma gamsii strain ICC 080 (product known, for example, as BIO-TAMTM from Bayer CropScience LP, US). Other examples of biological control agents that can be combined with the combination of compounds of the invention are: bacteria selected from the group consisting of Bacillus cereus, in particular B. cereus strain CNCM I1562 and Bacillus firmus, strain I-1582 (Accession number CNCM I-1582), Bacillus subtilis strain OST 30002 237470 1336027 of 49 (NRRL Accession No. B-50421), Bacillus thuringiensis, in particular B. thuringiensis subspecies israelensis (serotype H-14), strain AM65-52 (ATCC Accession No. 1276), B. thuringiensis subsp. aizawai, particularly strain ABTS-1857 (SD-1372), B. thuringiensis subsp. kurstaki strain HD-1, B. thuringiensis subsp. tenebrionis strain NB 176 (SD-5428), Pasteuria penetrans, Pasteuria spp. (nematode Rotylenchulus reniformis)-PR3 (ATCC Accession Number SD-5834), Streptomyces microflavus strain AQ6121 (= QRD 31.013, NRRL B-50550), and Streptomyces galbus strain AQ 6047 (NRRL Accession Number 30232); fungi and yeasts selected from the group consisting of Beauveria bassiana, in particular strain ATCC 74040, Lecanicillium spp., in particular strain HRO LEC 12, Metarhizium anisopliae, in particular strain F52 (DSM3884 or ATCC 90448), Paecilomyces fumosoroseus (now: Isaria fumosorosea), in particular strain IFPC 200613, or strain Apopka 97 (Accession Number ATCC 20874), and Paecilomyces lilacinus, in particular P. lilacinus strain 251 (AGAL 89 / 030550); Selected viruses from the group consisting of Adoxophyes orana (summer fruit tortrix) granulosis virus (GV), Cydia pomonella (apple moth) granulosis virus (GV), Helicoverpa armigera (cotton bollworm) nuclear polyhedrosis virus (NPV), Spodoptera exigua (beet armyworm) mNPV, Spodoptera frugiperda (fall armyworm) mNPV, and Spodoptera littoralis (African cotton blackworm) NPV. bacteria and fungi that can be incorporated as “inoculants” into plants or parts of plants or plant organs and that, by virtue of their particular properties, promote plant growth and health. Examples are: Agrobacterium spp., Azorhizobium caulinodans, Azospirillum spp., Azotobacter spp., Bradyrhizobium spp., Burkholderia spp., in particular Burkholderia cepacia (previously known as Pseudomonas cepacia), Gigaspora spp., or Gigaspora monosporum, Glomus spp., Laccaria spp., Lactobacillus buchneri, Paraglomus spp., Pisolithus tinctorus, Pseudomonas spp., Rhizobium spp., in particular Rhizobium trifolii, Rhizopogon spp., Scleroderma spp., Suillus spp., and Streptomyces spp. plant extracts and products formed by microorganisms including proteins and secondary metabolites that can be used as biological control agents, such as Allium sativum, Artemisia absinthium, azadirachtin, Biokeeper WP, Cassia nigricans, Celastrus angulatus, Chenopodium anthelminticum, chitin, Armour-Zen, Dryopteris filix-mas, Equisetum arvense, Fortune Aza, Fungastop, Heads Up (Chenopodium quinoa saponin extract), Pyrethrum / Pyrethrins, Quassia amara, Quercus, Quillaja, Regalia, Requiem ™ Insecticide, rotenone, ryania / ryanodina, Symphytum officinale, Tanacetum vulgare, thymol, Triact 70, TriCon, Tropaeulum majus, Urtica dioica, Veratrin, Viscum album, extract Brassicaceae, in particular rapeseed powder or mustard powder. Examples of insecticides, acaricides, and nematicides, respectively, that could be mixed with the combination of compounds of the invention are: 237470 1336027 of 49 (1) Acetylcholinesterase (AChE) inhibitors, such as, for example, carbamates, for example, alanicarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, etiofencarb, fenobucarb, formetanate, furatiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiophanox, triazamate, trimetacarb, XMC and xylylcarb, or organophosphates, for example, acephate, azamethiphos, azinphos-ethyl, azinphos-methyl, cadusafos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famfur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenofos, imiciaphos, isofenphos, isopropyl O-(methoxyaminothiophosphoryl) salicylate, isoxation, malathion, mecarbam, metamidophos, metidathion, mevinphos, monocrotophos, naled, omethoate, oxidemeton-methyl, parathion-methyl, fentoate, phorate,fosalone, fosmet, fosfamidon, phoxim, pirimifos-methyl, profenofos, propetamphos, prothiofos, pyraclofos, pyridafenthion, quinalfos, sulfotep, tebupirimphos, temefos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon and vamidothion. (2) GABA-regulated chloride channel blockers, such as, for example, organochlorine cyclodiene, for example, chlordane and endosulfan, or phenylpyrazoles (fiproles) selected from etiprol and fipronil. (3) Sodium channel modulators, such as, for example, pyrethroids, for example acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin isomers, s-cyclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyfenothrin [(1R)trans-isomer], deltamethrin, empentrin [(EZ)-(1R)-isomer], esfenvalerate, etofenprox, fenpropatrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, imiprothrin, kadethrin, momfluorothrin, permethrin, phenothrin [(1R)-trans-isomer], praletrin, pyrethrins (pyrethrum), resmethrin, silafluofen, tefluthrin tetramethrin, tetramethrin [(1R)- isomer)], tralomethrin and transfluthrin or DDT or methoxychlor. (4) Competitive modulators of the nicotinic acetylcholine receptor (nAChR), such as, for example, neonicotinoids, for example, acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam, or nicotine, or sulfoxaflor or flupyradifurone. (5) Allosteric modulators of the nicotinic acetylcholine receptor (nAChR), such as spinosines, for example spinetoram and spinosad. (6) Allosteric modulators of the glutamate-regulated chloride channel (GluCl), such as, for example, avermectins / milbemycins, for example abamectin, emamectin benzoate, lepimectin and milbemectin. (7) Juvenile hormone mimics, such as, for example, juvenile hormone analogues such as hydroprene, kinoprene and methoprene, or phenoxycarb or pyriproxyfen. 237470 1336027 of 49 (8) Miscellaneous non-specific (multi-site) inhibitors, such as, for example, alkyl halides, e.g. methyl bromide and other alkyl halides, or chloropicrin or sulfuryl fluoride or borax or tartar emetic or methyl isocyanate generators, e.g. diazomet and metam. (9) Modulators of the chordotonal organs, such as, for example, pimetrozine or flonicamid. (10) Mite growth inhibitors, for example clofentezine, hexythiazox and diflovidazine or etoxazole. (11) Microbial disruptors of insect intestinal membranes such as, for example, Bacillus thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, and Bt plant proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Ciy34Ab1 / 35Ab1. (12) Mitochondrial ATP synthase inhibitors, such as ATP disruptors such as, for example, diaphenthiuron, or organotin compounds such as azocyclotine, cyhexatine and phenbutatine oxide, or propargite or tetradiphon. (13) Uncouplers of oxidative phosphorylation through breaking up of the proton gradient, such as, for example, chlorfenapyr, DNOC and sulfluramid. (14) Nicotinic acetylcholine receptor channel blockers such as, for example, bensultap, cartap hydrochloride, tiocilam and tiosultap-sodium. (15) Chitin biosynthesis inhibitors, type 0, such as, for example, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron. (16) Inhibitors of chitin biosynthesis, type 1, for example buprofezin. (17) Molting disruptor (particularly for Diptera, i.e., flies) such as, for example, cyromazine. (18) Ecdysone receptor agonists such as, for example, chromafenozide, halofenozide, methoxyfenozide, and tebufenozide. (19) Octopamine receptor agonists, such as amitraz. (20) Inhibitors of electron transport of mitochondrial complex III such as, for example, hydramethylnon or acequinocil or fluacripyrime. (21) Inhibitors of electron transport of mitochondrial complex I such as, for example, METI acaricides such as phenazaquine, fenpyroximate, pirimidifene, pyridaben, tebufenpyrad and tolfenpyrad, or rotenone (Derris). 237470 1336027 of 49 (22) Voltage-dependent sodium channel blockers such as, for example, indoxacarb or metaflumizone. (23) Acetyl CoA carboxylase inhibitors such as, for example, tetronic and tetramic acid derivatives, for example spirodiclofen, spiromesifen and spirotetramat. (24) Inhibitors of electron transport of mitochondrial complex IV such as, for example, phosphines, for example aluminum phosphide, calcium phosphide, zinc phosphide and phosphide, or cyanides for example calcium cyanide, potassium cyanide and sodium cyanide. (25) Inhibitors of electron transport of mitochondrial complex II such as, for example, beta-ketonitrile derivatives such as cyenopyrafen and cyflumethophen, or carboxanilides such as, for example, piflubumide. (28) Ryanodine receptor modulators such as, for example, diamides such as chlorantraniliprole, cyantraniliprole and flubendiamide. Other known compounds such as, for example, Afidopyropene, Afoxolaner, Azadirachtin, Benzlothiaz, Benzoximate, Bifenazate, Broflanilide, Bromopropylate, Quinomethionate, Chloroplaethrin, Cryolite, Cyclaniliprol, Cycloxaprid, Cyhalodiamide, Dichloromezothiaz, Dicofol, epsilon-Metofluthrin, epsilon-Momfluthrin, Flometoquin, Fluazaindolizine, Fluensulfone, Flufenerim, Fluphenoxystrobin, Flufiprol, Fluhexafon, Fluopyram, Fluralaner, Fluxamethamide, Fufenozide, Guadipyr, Heptafluthrin, Imidaclotiz, Iprodione, kappa-Bifentrin, kappa-Tefluthrin, Lotilaner, Meperfluthrin, Paichongding, Piflubumide, Pyridalyl, Pyrifluquinazon, Pyriminoestrobin, Spironibodiclofen, Tetramethylfluthrin, Tetraniliprol, Tetrachlorantraniliprole, Tigolaner, Thioxazaphene, Thiofluoximate, Triflumezopyrim, and Iodomethane; additional products based on Bacillus firmas (I-1582, BioNeem, Votivo) and also the following compounds: 1-{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazol-5-amine (disclosed by WO2006 / 043635) (CAS 885026-50-6), {1'-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]-5-fluorospiro[indol3,4'-piperidin]-1(2H)-yl}(2-chloropyridin-4-yl)methanone (disclosed by WO2003 / 106457) (CAS 637360-237), 2-chloro-N-[2-{1-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]piperidin-4-yl}-4(trifluoromethyl)phenyl]isonicotinamide (disclosed by WO2006 / 003494) (CAS 872999-66-1), 3-(4-chloro-2,6dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one (disclosed by WO 2010052161) (CAS 1225292-17-0), 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate (disclosed by EP2647626) (CAS 1440516-42-6), 4-(but-2-in-1-yloxy)-6-(3,5-dimethylpiperidin1-yl)-5-fluoropyrimidine (disclosed by WO2004 / 099160) (CAS 792914-58-0), PF1364 (disclosed by JP2010 / 018586) (CAS 1204776-60-2), N-[(2E)-1 -[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-ylidene]-2,2,2trifluoroacetamide (disclosed by WO2012 / 029672) (CAS 1363400-41-2),(3E)-3-[1-[(6-chloro-3pyridyl)methyl]-2-pyridylidene]-1,1,1-trifluoro-propan-2-one (disclosed by WO2013 / 144213) (CAS 1461743-15-6), N-[3-(benzylcarbamoyl)-4-chlorophenyl]-1 -methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1Hpyrazole-5-carboxamide (disclosed by WO2010 / 051926) (CAS 1226889-14-0), 5-bromo-4-chloro-N-[421, 237470 1336027 of 49 chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazol-3-carboxamide (disclosed by CN103232431) (CAS 1449220-44-3), 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2methyl-N-( cis-1-oxido-3-thietanyl)-benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3isoxazolyl]-2-methyl-N-(trans -1-oxido-3-thietanyl)-benzamide and 4-[(5 S)-5-(3,5-dichlorophenyl)-4,5-dihydro-5(trifluoromethyl)-3-isoxazolyl] -2-methyl-N-(cis -1 -oxido-3-thietanyl)benzamide (disclosed by WO 2013 / 050317 A1) (CAS 1332628-83-7), N-[3-chloro-1-(3-pyridinyl)-1 H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3trifluoropropyl)sulfinyl]-propanamide, (+)-N-[3-chloro-1-(3-pyridinyl)-1 H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3trifluoropropyl)sulfinyl]-propanamide and (-)-N-[3-chloro-1-(3-pyridinyl)-1 H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3trifluoropropyl)sulfinyl]-propanamide (disclosed by WO 2013 / 162715 A2, WO 2013 / 162716 A2, US 2014 / 02137448 5-[[(2 E)-3-chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4(trifluoromethyl)phenyl] -4-[(trifluoromethyl)sulfinyl] -1H-pyrazol-3 -carbonitrile (disclosed by CN 101337937 A) (CAS 1105672-77-2), 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)thioxomethyl]phenyl]-1(3-chloro-2-pyridinyl)-1 H-pyrazol-5-carboxamide, (Liudaibenjiaxuanan, disclosed by CN 103109816 A) (CAS 1232543-85-9); N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)3-(fluoromethoxy)-1H-Pyrazol-5-carboxamide (disclosed by WO 2012 / 034403 A1) (CAS 1268277-22-0), N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-carboxamide (disclosed by WO 2011 / 085575 A1) (CAS 1233882-22-8), 4-[3-[2,6-dichloro-4-[(3,3-dichloro2-propen-1-iyl)oxy]phenoxy]propoxy]-2-methoxy-6-(trifluoromethyl)-pyrimidine (disclosed by CN 101337940 A) (CAS 1108184-52-6); (2E)- y 2(Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy)phenyl]-hydrazinecarboxamide (disclosed under CN 101715774 A) (CAS 1232543-85-9); 3-(2,2-dichloroethenyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenylcyclopropanecarboxylic acid ester (disclosed under CN 103524422 A) (CAS 1542271-46-4); (4aS)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)thio]phenyl]amino]carbonyl]-indeno[1,2- and ][1,3,4]oxadiazine-4a(3H)-carboxylic acid methyl ester (disclosed by CN 102391261 A) (CAS 1370358-69-2); 6-deoxy-3O -ethyl-2,4-di-O -methyl-, 1-[N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1H-1,2,4-triazol-3-yl]phenyl] carbamate]-aL-mannopyranosa (disclosed by US 2014 / 0275503 A1) (CAS 1181213-14-8); 8-(2cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethyl-pyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane (CAS 1253850-56-4), (8-anti)-8-(2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane (CAS 933798-27-7), (8-syn)-8-(2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethyl-pyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane (disclosed by. WO 2007040280 A1, WO 2007040282 A1) (CAS 934001-66-8), N-[3-chloro-1-(3-pyridinyl)-1H-pyrazole-4yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]-propanamide (disclosed by WO 2015 / 058021 A1, WO 2015 / 058028 A1) (CAS 1477919-27-9) y N-[4-(aminothioxomethyl)-2-methyl-6-[(methylamino)carbonyl]phenyl]3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-carboxamida (disclosed by CN 103265527 A) (CAS 1452877-50-7), 5-(1,3-dioxan-2-yl)-4-[[4-(trifluoromethyl)phenyl]methoxy]-pyrimidine (disclosed by WO 2013 / 115391 A1) (CAS 1449021-97-9), 3-(4-chloro-2,6-dimethylphenyl)-4-hidroxi-8-methoxi-1-methyl-1,8diazaespiro[4.5]dec-3-en-2-ona (disclosed by WO 2010 / 066780 A1, WO 2011 / 151146 A1) (CAS 1229023-34-0), 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-1,8-diazaespiro[4.5]decane-2,4-diona 237470 1336027 of 49 (disclosed by WO 2014 / 187846 A1) (CAS 1638765-58-8), ethyl ester of 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaespiro[4.5]dec-3-en-4-yl-carbonic acid (disclosed by WO 2010 / 066780 A1, WO 2011151146 A1) (CAS 1229023-00-0), N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)pyridinylidene]-2,2,2-trifluoroacetamide (disclosed by DE 3639877 A1, WO 2012029672 A1) (CAS 1363400-41-2), [N(E)]-N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoroacetamide, (disclosed by WO 2016005276 A1) (CAS 1689566-03-7), [N(Z)]-N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoroacetamide, (CAS 1702305-40-5), 3-endo-3-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-9-azabicyclo[3.3.1]nonane (disclosed by WO 2011 / 105506 A1, WO 2016 / 133011 A1) (CAS 1332838-17-1). Examples of protectants that could be mixed with the combination of compounds of the invention are, for example, benoxacor, cloquintocet (-mexyl), ciometrinil, cyprosulfamide, dichlormid, fenchlorazol (-ethyl), fenchlorim, flurazol, fluxofenim, furylazol, isoxadifen (-ethyl), mefenpyr (-diethyl), naphthalic anhydride, oxabetrinil, 2-methoxy-N-({4-[(methylcarbamoyl)amino]phenyl}sulfonyl)benzamide (CAS 129531-12-0), 4(dichloroacetyl)-1-oxa-4-azaspiro[4,5]decane (CAS 71526-07-3), 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine (CAS 52836-31-4). Examples of herbicides that could be mixed with the combination of compounds of the invention are: Acetochlor, acifluorfen, acifluorfen-sodium, aclonifene, alachlor, alidochlor, alloxidim, alloxidim-sodium, ametrine, amicarbazone, amidochlor, amidosulfuron, 4-amino-3-chloro-6-(4-chloro-2-fluoro-3methylphenyl)-5-fluoropyridine-2-carboxylic acid, aminocyclopyrachlor, aminocyclopyrachlor-potassium, aminocyclopyrachlor-methyl, aminopyralide, amitrol, ammoniosulfamate, anilophos, asulam, atrazine, azaphenidine, azimsulfuron, beflubutamide, benazolin, benazolin-ethyl, benfluralin, benfuresate, bensulfuron, bensulfuron-methyl, bensulide, bentazone, benzobicyclone, benzofenap, biciclopirone, bifenox, bilanafos, bilanafos-sodium, bispiribac, bispiribac-sodium, bromacil, bromobutide, bromophenoxime, bromoxynyl, bromoxynyl-butyrate, -potassium, -heptanoate, and -octanoate, busoxinone, butachlor, butafenacyl, butamiphos, butenachlor, butralin, butroxydin, butylate, cafenstrol, carbetamide, carfentrazone, carfentrazone-ethyl, chloramben, chlorbromuron, chlorfenac, chlorfenac-sodium, chlorfenprop, chlorflurenol,chlorflurenol-methyl, chloridazone, chlorimuron, chlorimuron-ethyl, chlorophthalim, chlorotoluron, chlorthal-dimethyl, chlorsulfuron, cinidon, cinidon-ethyl, cinmethylin, cinnosulfuron, clacifos, clethodim, clodinafop, clodinafoppropargyl, clomazone, clomeprop, clopyralide, chloransulam, chloransulam-methyl, cumiluron, cyanamide, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop, cyhalofop-butyl, cypriazine, 2,4-D, 2,4-D-butyl, -butyl, -dimethylammonium, -diolamine, -ethyl, -2-ethylhexyl, -isobutyl, -isooctyl, -isopropylammonium, -potassium -triisopropanolammonium, and -trolamine, 2,4-DB, 2,4-DB-butyl, -dimethylammonium, isooctyl, -potassium, and -sodium, daimuron (dymron), dalapon, dazomet, n-decanol, desmedipham, detosylpyrazolate (DTP), dicamba, dichlobenyl, 2-(2,4-dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, 2-(2,5dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, diclofop-P-methyl, diclosulam, difenzoquat, diflufenican,diflufenzopyr, diflufenzopyr-sodium, dimefuron, 237470 1336027 of 49 dimepiperate, dimetachlor, dimethamethrin, dimethenamide, dimethenamide-P, dimetrasulfuron, dinitramine, dinoterb, diphenamide, diquat, diquat-dibromide, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, etalfluralin, etametsulfuron, etametsulfuron-methyl, etiozine, etofumesate, ethoxyphene, ethoxyphene-ethyl, ethoxysulfuron, etobenzanid, F-9600, F-5231, i.e. N-{2-chloro-4-fluoro-5-[4-(3-fluoropropyl)-5-oxo4,5-dihydro-1H-tetrazol-1-yl]phenyl}ethanesulfonamide, F-7967, i.e. 3-[7-chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, phenquinetrione, fentrazamide, flamprop, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloraline, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumicloracflumiclorac-pentyl, flumioxazine, fluometuron, flurenol, flurenol-butyl, -dimethylamonium y -methyl, fluoroglycophene, fluoroglycophene-ethyl, flupropanate, flupyrsulfuron, flupyrsulfuron-methyl-sodium, fluridona, flurochloridona, fluroxypyr, fluroxypirmeptyl, flurtamona, flutiacet, flutiacet-methyl, fomesafeno, fomesafen-sodium, foramsulfuron, fosamine, glufosinate, glufosinate-amonium, glufosinate-P-sodium, glufosinate-P-amonium, glufosinate-P-sodium, glyphosate, glyphosate-amonium, -isopropylamonium, -diamonium, -dimethylamonium, -potassium, -sodium, y -trimesium, H-9201, e.g. decir O-(2,4-dimethyl-6-nitrophenyl) O-ethyl isopropylphosphoramidothioate, halauxifeno, halauxifenmethyl, halosafeno, halosulfuron, halosulfuron-methyl, haloxifop, haloxifop-P, haloxifop-ethoxyethyl, haloxifop-P-ethoxyethyl, haloxifop-methyl, haloxifop-P-methyl, hexazinona, HW-02, es decir 1-(dimethoxyphosphoryl) ethyl-(2,4-dichlorophenoxy)acetate, imazametabenz, imazametabenz-methyl, imazamox, imazamoxamonium, imazapic, imazapic-amonio,imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonio, imazetapyr, imazetapyr-imonium, imazosulfuron, indanofan, indaziflam, iodosulfuron, iodosulfuron-methylsodium, ioxinil, ioxynyl-octanoate, -potassium and -sodium, ipfencarbazone, isoproturon, isouron, isoxabene, isoxaflutol, karbutylate, KUH-043, i.e. 3-({[5-(difluoromethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole, ketospiradox, lactofen, lenacil, linuron, MCPA, MCPA-butotil, -dimethylammonium, -2-ethylhexyl, -isopropylammonium, -potassium, and -sodium, MCPB, MCPBmethyl, -ethyl, and -sodium, mecoprop, mecoprop-sodium, and -butoyl, mecoprop-P, mecoprop-P-butoyl, dimethylammonium, -2-ethylhexyl, and -potassium, mefenacet, mefluidide, mesosulfuron, mesosulfuron-methyl, mesotrione, metabenzthiazureon, metam, metamifop, metamitron, metazachlor, metazosulfuron, metabenzthiazureon, methiopyrsulfuron, methiazoline, methyl isothiocyanate, methobromuron, metolachlor, S-metolachlor, metosulam, metoxuron,metribuzin, metsulfuron, metsulfuron-methyl, molinat, monolinuron, monosulfuron, monosulfuron-ester, MT-5950, i.e., N-(3-chloro-4-isopropylphenyl)-2-methylpentanamide, NGGC-011, napropamide, NC-310, i.e., [5-(benzyloxy)-1-methyl-1H-pyrazol-4-yl](2,4-dichlorophenyl)methanone, neburon, nicosulfuron, nonanoic acid (pelargonic acid), norflurazone, oleic acid (fatty acids), orbencarb, orthosulfamuron, oryzaline, oxadiargil, oxadiazon, oxasulfuron, oxaziclomefon, oxyfluorphen, paraquat, paraquat dichloride, pebulate, pendimethalin, penoxsulam pentachlorphenol, pentoxazone, petoxamide, petroleum oils, fenmedifam, picloram, picolinafen, pinoxaden, piperophos, pretilaclor, primisulfuron, primisulfuron-methyl, prodiamine, profoxidim, prometon, promethrin, propachlor, propanyl, propaquizafop, propazine, profam, propisochlor, propoxycarbazone, 237470 1336027 of 49 propoxycarbazone-sodium, propirisulfuron, propizamide, prosulfocarb, prosulfuron, pyraclonil, piraflufen, piraflufen-ethyl, pyrasulfotol, pyrazolinate (pyrazolate), pyrazosulfuron, pyrazosulfuron-ethyl, pyrazoxyfen, piribambenz, piribambenz-isopropyl, piribambenz-propyl, pyribenzoxime, pyributicarb, pyridafol, pyridate, pyrifthalide, piriminobac, piriminobac-methyl, pirimisulfan, piritiobac, piritiobac-sodium, pyroxasulfone, piroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simethrin, SL-261, sulcotrion, sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosulfuron, SYN-523, SYP-249, i.e. 1-ethoxy-3-methyl-1-oxobut-3-en-2-yl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate, SYP-300, i.e. 1-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA,TCA (trichloroacetic acid), TCA-sodium, tebutiuron, tefuryltrione, tembotrione, tepraloxidim, terbacil, terbucarb, terbumeton, terbuthylazine, terbutrine, tenylchlor, thiazopyr, thiencarbazone, thiencarbazone-methyl, tifensulfuron, tifensulfuron-methyl, thiobencarb, thiaphenacil, tolpyralate, topramezone, tralcoxidim, triafamone, tri-alate, triasulfuron, triaziflam, tribenuron, tribenuron-methyl, triclopyr, trietazine, trifloxysulfuron, trifloxysulfuron-sodium, trifludimoxazine, trifluralin, triflusulfuron, triflusulfuron-methyl, tritosulfuron, urea sulfate, vernolate XDE-848, ZJ-0862, namely 3,4-dichloro-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}aniline, and the following compounds:, Examples of plant growth regulators are: Acibenzolar, acibenzolar-S-methyl, 5-aminolevulinic acid, acimidol, 6-benzylaminopurine, brassinolid, catechin, chlormequat chloride, cloprop, cyclanilide, 3-(cycloprop-1-enyl)propionic acid, daminozide, dazomet, n-decanol, dikegulac, dikegulac-sodium, endothal, endothal-dipotassium, -disodium, and -mono(N,N-dimethylalkylammonium), ethephon, flumethralin, flurenol, flurenol-butyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfide, indole-3-acetic acid (IAA), 4-indole-3-yl-butyric acid, isoprothiolane, probenazole, jasmonic acid, maleic hydrazide, mepiquat chloride 1-methylcyclopropene, methyl jasmonate, 2-(125 237470 1336027 of 49 naphthyl)acetamide, 1-naphthylacetic acid, 2-naphthyloxyacetic acid, nitrophenolate mixture, paclobutrazol, N(2-phenylethyl)-beta-alanine, N-phenylphthalamic acid, prohexadione, prohexadione-calcium, prohydrojasmona, salicylic acid, strigolactone, tecnazene, thidiazuron, triacontanol, trinexapac, trinexapac-ethyl, tsitodef, uniconazole, uniconazole-P. Methods and uses The invention also relates to a method for controlling unwanted microorganisms, in particular phytopathogenic fungi, characterized in that a combination of compounds according to the invention or a composition comprising such a combination is applied to the microorganisms and / or their habitat. The invention also relates to a seed that has been treated with a combination of compounds according to the invention or a composition comprising such a combination. The invention ultimately provides a method of protecting seeds against unwanted microorganisms by treating the seed with a combination of compounds according to the invention or a composition comprising such a combination. The combinations of compounds according to the invention and the compositions comprising such combinations have potent microbicidal activity and can be used for the control of unwanted microorganisms, such as fungi and bacteria, in crop protection and in the protection of materials. The combinations of compounds according to the invention and the compositions comprising such combinations have very good fungicidal properties and can be used in crop protection, for example for the control of Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes. It is possible to use bactericides in crop protection, for example, for the control of Pseudomonadaceae, Rhizobiaceae, Enterobacteriaceae, Corynebacteriaceae and Streptomycetaceae. The combinations of compounds according to the invention and the compositions comprising such combinations can be used for the curative or protective control of phytopathogenic fungi. Accordingly, the invention also relates to curative and protective methods for the control of phytopathogenic fungi by using the inventive combinations or compositions, which are applied to the seed, plant or parts of the plant, the fruit, or the soil in which the plants grow. Floors All plants and parts of plants can be treated according to the invention. Herein, the term "plants" refers to all plants and plant populations, such as desired and unwanted wild plants or cultivated plants (including naturally occurring crops). 237470 1336027 of 49. Cultivated plants may be obtained through conventional breeding and optimization methods or through biotechnological and genetic engineering methods, or combinations of these methods, including transgenic plants and plant varieties that may or may not be protected by plant variety rights. The term "plants" is understood to encompass all developmental stages, from seeds and seedlings to young (immature) plants and mature plants. "Parts of plants" includes all parts and organs of plants above and below ground, such as shoots, leaves, flowers, and roots, including leaves, thorns, stems, trunks, flowers, fruiting bodies, fruits, and seeds, as well as roots, tubers, and rhizomes. Parts of plants also include harvested material and material of vegetative and generative propagation, such as cuttings, tubers, rhizomes, grafts, and seeds.The plants that can be treated according to the invention are the following: cotton, flax, vine, fruits, vegetables, such as Rosaceae sp. (for example, pome fruits such as apples and pears, but also stone fruits such as apricots, cherries, almonds and peaches, and red fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example, banana trees and plantations), Rubiaceae sp. (for example, coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example, lemons, oranges and grapefruits); Solanaceae sp. (for example, tomatoes), Liliaceae sp., Asteraceae sp. (for example, lettuce), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (e.g. cucumber), Alliaceae sp. (e.g. leek, onion), Papilionaceae sp. (e.g. peas); the main cultivated plants, such as Gramineae sp.(for example, corn, turfgrass, cereals such as wheat, rye, rice, barley, oats, millet, and triticale), Asteraceae sp. (for example, sunflower), Brassicaceae sp. (for example, white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, swede, radishes, rapeseed, mustard, horseradish, and cress), Fabaceae sp. (for example, beans, peanuts), Papilionaceae sp. (for example, soybeans), Solanaceae sp. (for example, potatoes), Chenopodiaceae sp. (for example, sugar beets, fodder beets, chard, beets); useful plants and ornamental plants for gardens and woodland areas; and genetically modified varieties of each of these plants. Pathogens Non-limiting examples of fungal disease pathogens that can be treated according to the invention include: diseases caused by powdery mildew pathogens, for example Blumeria species, for example Blumeria graminis; Podosphaera species, for example Podosphaera leucotricha; Sphaerotheca species, for example Sphaerotheca fuliginea; Uncinula species, for example Uncinula necator; diseases caused by rust disease pathogens, for example Gymnosporangium species, for example Gymnosporangium sabinae; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae; Puccinia species, for example 237470 1336027 of 49 Puccinia recondita, Puccinia graminis order Puccinia striiformis; Uromyces species, e.g. Uromyces appendiculatus; diseases caused by pathogens of the Oomycetes group, for example Albugo species, for example Albugo candida; Bremia species, for example Bremia lactucae; Peronospora species, for example Peronospora pisi or P. brassicae; Phytophthora species, for example Phytophthora infestans; Plasmopara species, for example Plasmopara viticola; Pseudoperonospora species, for example Pseudoperonospora humuli or Pseudoperonospora cubensis; Pythium species, for example Pythium ultimum; Leaf spot diseases and wilt diseases caused, for example, by Alternaria species, for example Alternaria solani; Cercospora species, for example Cercospora beticola; Cladiosporium species, for example Cladiosporium cucumerinum; Cochliobolus species, for example Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium) or Cochliobolus miyabeanus; Colletotrichum species, for example Colletotrichum lindemuthanium; Cycloconium species, for example Cycloconium oleaginum; Diaporthe species, for example Diaporthe citri; Elsinoe species, for example Elsinoe fawcettii; Gloeosporium species, for example Gloeosporium laeticolor; Glomerella species, for example Glomerella cingulata; Guignardia species, for example Guignardia bidwelli; Leptosphaeria species, for example Leptosphaeria maculans; Magnaporthe species, for example Magnaporthe grisea; Microdochium species, for example Microdochium nivale;Mycosphaerella species, for example Mycosphaerella graminicola, Mycosphaerella arachidicola or Mycosphaerella fijiensis; Phaeosphaeria species, for example Phaeosphaeria nodorum; Pyrenophora species, for example Pyrenophora teres or Pyrenophora tritici repentis; Ramularia species, for example Ramularia collo-cygni or Ramularia areola; Rhynchosporium species, for example Rhynchosporium secalis; Septoria species, for example Septoria apii or Septoria lycopersici; Stagonospora species, for example Stagonospora nodorum; Typhula species, for example Typhula incarnata; Venturia species, for example Venturia inaequalis; Root and stem diseases caused, for example, by Corticium species, for example Corticium graminearum; Fusarium species, for example Fusarium oxysporum; Gaeumannomyces species, for example Gaeumannomyces graminis; Plasmodiophora species, for example Plasmodiophora brassicae; Rhizoctonia species, for example Rhizoctonia solani; Sarocladium species, for example Sarocladium oryzae; Sclerotium species, for example Sclerotium oryzae; Tapesia species, for example Tapesia acuformis; Thielaviopsis species, for example Thielaviopsis basicola; diseases of ears and panicles (including maize ears) caused, for example, by Alternaria species, for example Alternaria spp.; Aspergillus species, for example Aspergillus flavus; Cladosporium species, for example Cladosporium cladosporioides; Claviceps species, for example Claviceps purpurea; Fusarium species, for example Fusarium culmorum; Gibberella species, for example Gibberella zeae; Monographella species, for example Monographella nivalis; Stagnospora species, for example Stagnospora nodorum; 237470 1336027 of 49 diseases caused by obscene fungi, for example Sphacelotheca species, for example Sphacelotheca reiliana; Tilletia species, for example Tilletia caries or Tilletia controversa; Urocystis species, for example Urocystis occulta; Ustilago species, for example Ustilago nuda; fruit rot caused, for example, by Aspergillus species, for example Aspergillus flavus; Botrytis species, for example Botrytis cinerea; Penicillium species, for example Penicillium expansum or Penicillium purpurogenum; Rhizopus species, for example Rhizopus stolonifer; Sclerotinia species, for example Sclerotinia sclerotiorum; Verticillium species, for example Verticillium alboatrum; seed- and soil-borne rot and wilt diseases, and also seedling diseases, caused, for example, by Alternaria species, for example Alternaria brassicicola; Aphanomyces species, for example Aphanomyces euteiches; Ascochyta species, for example Ascochyta lentis; Aspergillus species, for example Aspergillus flavus; Cladosporium species, for example Cladosporium herbarum; Cochliobolus species, for example Cochliobolus sativus (conidial form: Drechslera, Bipolaris Syn: Helminthosporium); Colletotrichum species, for example Colletotrichum coccodes; Fusarium species, for example Fusarium culmorum; Gibberella species, for example Gibberella zeae; Macrophomina species, for example Macrophomina phaseolina; Microdochium species, for example Microdochium nivale; Monographella species, for example Monographella nivalis; Penicillium species, for example Penicillium expansum; Phoma species, for example Phoma lingam;Phomopsis species, for example Phomopsis sojae; Phytophthora species, for example Phytophthora cactorum; Pyrenophora species, for example Pyrenophora graminea; Pyricularia species, for example Pyricularia oryzae; Pythium species, for example Pythium ultimum; Rhizoctonia species, for example Rhizoctonia solani; Rhizopus species, for example Rhizopus oryzae; Sclerotium species, for example Sclerotium rolfsii; Septoria species, for example Septoria nodorum; Typhula species, for example Typhula incarnata; Verticillium species, for example Verticillium dahliae; cancers, galls and witches' broom caused, for example, by Nectria species, for example Nectria galligena; wilt diseases caused, for example, by Monilinia species, for example Monilinia laxa; Deformations of leaves, flowers and fruits caused, for example, by Exobasidium species, for example Exobasidium vexans; Taphrina species, for example Taphrina deformans; degenerative diseases in woody plants, caused, for example, by Esca species, for example Phaeomoniella chlamydospora, Phaeoacremonium aleophilum or Fomitiporia mediterranea; Ganoderma species, for example Ganoderma boninense; diseases of flowers and seeds caused, for example, by Botrytis species, for example Botrytis cinerea; 237470 1336027 of 49 diseases of plant tubers caused, for example, by Rhizoctonia species, for example Rhizoctonia solani; Helminthosporium species, for example Helminthosporium solani; diseases caused by bacterial pathogens, for example Xanthomonas species, for example Xanthomonas campestris pv. oryzae; Pseudomonas species, for example Pseudomonas syringae pv. lachrymans; Erwinia species, for example Erwinia amylovora. Priority is given to controlling the following soybean diseases: Fungal diseases on leaves, stems, pods and seeds caused, for example, by Alternaria leaf spot (Alternaria spec. atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot (Septoria glycines), cercospora leaf spot and blight (Cercospora kikuchii), choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), leaf blight by dactuliophora (Dactuliophora glycines), hairy mildew (Peronospora manshurica), blight by drechslera (Drechslera glycini), frogeye foliar spot (Cercospora sojina), foliar spot by leptosphaerulina (Leptosphaerulina trifolii), foliar spot by phyllosticta (Phyllosticta sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), foliar spot by pyrenochaeta (Pyrenochaeta glycines), aerial, foliage and web blight by rhizoctonia (Rhizoctonia solani), rust (Phakopsora). pachyrhizi, Phakopsora meibomiae), scab (Sphaceloma glycines), Stemphylium leaf blight (Stemphylium botryosum), ringed spot (Corynespora cassiicola). Fungal diseases in the roots and stem base caused, for example, by black root rot (Calonectria crotalariae), charcoal rot (Macrophomina phaseolina), Fusarium blight or wilt, root rot and sheath and collar rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), Mycoleptodiscus root rot (Mycoleptodiscus terrestris), Neocosmospora (Neocosmospora vasinfecta), sheath and stem blight (Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var.caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythium rot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem rot and seedling blight (Rhizoctonia solani), sclerotinia stem rot (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola). In addition, preference is given to the control of leaf spot diseases and leaf wilt diseases, as well as diseases of the roots and stems of fruits and vegetables. Regulation of plant growth In some cases, combinations of compounds according to the invention and the composition comprising such combination may, at certain concentrations or application rates, also be used as growth regulators or agents to enhance the properties of plants. 237470 1336027 of 49 Plant growth regulators can have various effects on plants. The effect of the substances depends primarily on the timing of application relative to the plant's developmental stage, as well as the amount of active ingredient applied to the plants or their environment and the application method. In each case, the growth regulators should have a specific desired effect on the cultivated plants. Growth-regulating effects include early germination, improved emergence, more developed root system and / or improved root growth, greater tillering capacity, more productive tillers, early flowering, increased plant height and / or biomass, stem shortening, improved shoot growth, number of grains / ear, number of ears / m2, number of stolons and / or number of flowers, improved harvest index, larger leaves, fewer dead basal leaves, improved phyllotaxis, early fruit ripening / finishing, uniform ripening, longer grain filling time, better fruit finish, larger fruit / vegetable size, resistance to sprouting, and reduced lodging. Increased or improved yield refers to total biomass per hectare, yield per hectare, grain / fruit weight, seed size and / or hectoliter weight, as well as improved product quality, which includes: improved processability in relation to size distribution (e.g., grain or fruit), homogeneous ripening, grain moisture, better milling, better winemaking, better processing, higher juice yield, harvestability, digestibility, sedimentation value, settling number, pod stability, storage stability, improved fiber length / strength / uniformity, increased milk and / or quality of animals fed silage, suitability for cooking and frying; also including an improvement in marketability related to the improvement of fruit / grain quality, size distribution (e.g., grain or fruit), longer storage / shelf life, firmness / softness, flavor (aroma, texture), grade (size, shape, number of berries), number of berries / fruits per bunch, crisp texture, freshness, wax coating, frequency of physiological disorders, color; also including an increase in desired ingredients such as, for example, protein content, fatty acids, oil content, oil quality, amino acid composition, sugar content, acid content (pH), sugar / acid ratio (Brix), polyphenols, starch content, nutritional quality, gluten content / index, energy content, flavor; and also including a reduction of unwanted ingredients such as less mycotoxins, less aflatoxins, geosmin level, phenolic aromas, laccase, polyphenol oxidases and peroxidases, nitrate content. Plant growth regulators can be used, for example, to slow the vegetative growth of plants. This reduction in growth is of economic interest, for example, in 237470 1336027 of 49 in the case of grasses, since this makes it possible to reduce the frequency of mowing in ornamental gardens, parks and sports facilities, along roadsides, at airports or in fruit orchards. Inhibiting the growth of herbaceous and woody plants along roadsides and near pipes or overhead cables, or generally in areas where vigorous plant growth is undesirable, is also important. The use of growth regulators to inhibit the longitudinal growth of cereals is also important. This reduces or completely eliminates the risk of lodging before harvest. Furthermore, growth regulators in cereals can strengthen the culm, which also counteracts lodging. Using growth regulators to shorten and strengthen culms allows for the application of larger volumes of fertilizer to increase yield, without the risk of lodging in cereal crops. In many crops, suppressing vegetative growth allows for denser planting and, therefore, higher yields relative to the amount of soil. Another benefit of the smaller plants obtained in this way is that the crop is easier to cultivate and harvest. Reducing vegetative growth of the plant can also lead to increased or improved yields because nutrients and assimilates are more beneficial for the formation of flowers and fruits than for the vegetative parts of the plants. Alternatively, growth regulators can also be used to stimulate vegetative growth. This is highly beneficial when harvesting the vegetative parts of the plant. However, promoting vegetative growth can also promote generative growth, leading to the formation of more assimilates and resulting in more or larger fruit. In addition, beneficial effects on growth or performance can be achieved through improved nutrient use efficiency, especially nitrogen (N) use efficiency, phosphorus (P) use efficiency, water use efficiency, improved transpiration, respiration and / or CO2 assimilation rate, improved nodulation, and improved calcium metabolism. Similarly, growth regulators can be used to alter plant composition, which in turn can lead to improved quality of harvested products. Under the influence of growth regulators, parthenocarpic fruits can form. Furthermore, it is possible to influence the sex of flowers. It is also possible to produce sterile pollen, which is of great importance in the breeding and production of hybrid seeds. The use of growth regulators can control plant branching. On the one hand, by breaking apical dominance, it is possible to promote the development of lateral shoots, which can be very desirable, particularly in the cultivation of ornamental plants, also in combination with an inhibition of 237470 1336027 of 49 growth. On the other hand, however, it is also possible to inhibit the growth of lateral shoots. This effect is of particular interest, for example, in tobacco or tomato cultivation. Under the influence of growth regulators, the number of leaves on plants can be controlled so that defoliation occurs at the desired time. This defoliation plays an important role in the mechanical harvesting of cotton, but it is also beneficial for facilitating harvesting in other crops, such as viticulture. Defoliation can also be carried out to reduce transpiration before transplanting. In addition, growth regulators can modulate plant senescence, which can result in a longer duration of green leaf area, a longer grain-filling phase, and improved yield quality. Growth regulators can also be used to regulate fruit dehiscence. On the one hand, they can prevent premature fruit dehiscence. On the other hand, they can also promote fruit dehiscence or even flower abortion to achieve the desired fruit mass (thinning). Furthermore, growth regulators can be used at harvest to reduce the force required to detach the fruit, thus facilitating mechanical or manual harvesting. Growth regulators can also be used to accelerate or delay the ripening of harvested material before or after harvest. This is particularly advantageous as it allows for optimal adjustment to market demands. Furthermore, growth regulators can sometimes enhance fruit color. Additionally, growth regulators can be used to synchronize ripening within a specific timeframe. This establishes the necessary conditions for complete mechanical or manual harvesting in a single operation, for example, in the case of tobacco, tomatoes, or coffee. By using growth regulators, it is also possible to influence the dormancy of seeds or buds in plants, so that plants such as pineapples or ornamental plants in nurseries, for example, germinate, sprout, or flower at a time when they are not normally inclined to do so. In areas where there is a risk of frost, it may be advisable to delay sprouting or seed germination with the help of growth regulators to avoid damage from late frosts. Finally, growth regulators can induce plant resistance to frost, drought, or high soil salinity. This allows for the cultivation of plants in regions that are not normally suitable for such cultivation. Induction of resistance / Plant health and other effects 237470 1336027 of 49 Combinations of compounds according to the invention and compositions comprising such combinations can also exhibit a potent strengthening effect in plants. Consequently, they can be used to mobilize the plant's defenses against attack by undesirable microorganisms. Plant strengthening substances (resistance inducers) in the present context are substances capable of stimulating the defense system of plants in such a way that the treated plants, when subsequently inoculated with undesirable microorganisms, develop a high degree of resistance to these microorganisms. Furthermore, in the context of the present invention, the effects on plant physiology comprise the following: Tolerance to abiotic stress, which includes tolerance to high or low temperatures, tolerance to drought and recovery after drought stress, water use efficiency (which correlates with reduced water consumption), tolerance to flooding, ozone stress and UV tolerance, tolerance to chemicals such as heavy metals, salts, pesticides. Tolerance to biotic stress, which includes increased resistance to fungi and increased resistance to nematodes, viruses, and bacteria. In the context of the present invention, tolerance to biotic stress preferably includes increased resistance to fungi and increased resistance to nematodes. Increased plant vigor, which includes plant health / plant quality and seed vigor, reduced plant fall, improved appearance, greater recovery after periods of stress, improved pigmentation (e.g., chlorophyll content, permanence of greenness) and improved photosynthetic efficiency. Mycotoxins Furthermore, the combinations of compounds according to the invention and the compositions comprising such combinations can reduce the mycotoxin content in the harvested material and the food and feed prepared from it. Mycotoxins include, in particular, but not limited to, the following: deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2- and HT2 toxins, fumonisins, zearalenone, moniliformin, fusarin, diaceotoxyscirpenol (DAS), beauvericin, eniatin, fusaroproliferin, fusarenol, ochratoxins, patulin, ergot alkaloids, and aflatoxins, which can be produced, for example, by the following fungi: Fusarium spec., such as F. acuminatum, F. asiaticum, F. avenaceum, F. crookwellense, F. culmorum, F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proliferatum, F. poae, F. pseudograminearum, F. sambucinum, F. scirpi, F. semitectum, F. solani, F. sporotrichoides, F. langsethiae, F. subglutinans, F.tricinctum, F. verticillioides, and also by Aspergillus spec., such as A. flavus, A. parasiticus, A. nomius, A. ochraceus, A. clavatus, A. terreus, A. versicolor, Penicillium spec., such as P. verrucosum, P. viridicatum, P. citrinum, P. 237470 1336027 of 49 expansum, P. claviforme, P. roqueforti, Claviceps spec., such as C. purpurea, C. fusiformis, C. paspali, C. africana, Stachybotrys spec. and others. Materials Protection The combinations of compounds according to the invention and the compositions comprising such combinations can also be used in the protection of industrial materials, for the protection of industrial materials against attack and destruction by phytopathogenic fungi. Furthermore, the combinations of compounds according to the invention and the compositions comprising such combinations can be used as antifouling compositions, alone or in combination with other active ingredients. The term "industrial materials" in this context refers to inanimate materials that have been prepared for industrial use. For example, industrial materials to be protected by the compositions of the invention against microbial alteration or destruction may include adhesives, glues, paper, wallpaper and cardboard, textiles, carpets, leather, wood, fibers and fabrics, paints and plastic articles, refrigeration lubricants, and other materials that can be infected or destroyed by microorganisms. Also included within the scope of materials to be protected are parts of production plants and buildings, such as cooling water circuits, refrigeration and heating systems, and ventilation and air conditioning units, which may be affected by the proliferation of microorganisms.Industrial materials within the scope of the present invention preferably include adhesives, glues, paper and cardboard, leather, wood, paints, cooling lubricants and heat transfer fluids, most preferably wood. Combinations of compounds according to the invention and compositions comprising such combinations can prevent adverse effects such as rotting, decomposition, discoloration, discoloration, or mold formation. In the case of wood treatment, the combinations of compounds according to the invention and the compositions comprising such combinations can also be used against fungal diseases that may develop on or within the wood. The term “wood” refers to all types of wood species and all types of wood products intended for construction, for example, solid wood, high-density fiberboard, laminated timber, and veneer. The method of treating wood according to the invention consists primarily of bringing it into contact with a composition according to the invention; this includes, for example, direct application, spraying, immersion, injection, or any other suitable means. Furthermore, the combinations of compounds according to the invention and the compositions comprising such combinations can be used to protect objects from fouling. 237470 1336027 of 49 in contact with hard water or brackish water, especially hulls, meshes, nets, buildings, moorings and signaling systems. The combinations of compounds according to the invention and the compositions comprising such combinations can also be used to protect goods in storage. Goods in storage are defined as natural substances of plant or animal origin, or their processed products of natural origin, for which long-term protection is desired. Plant-based products in storage, such as plants or parts of plants, including stems, leaves, tubers, seeds, fruits, and grains, can be protected freshly harvested or after processing by (pre)drying, wetting, crushing, grinding, pressing, or roasting. Products in storage also include wood, both unprocessed, such as construction timber, utility poles, and fences, and in the form of finished products, such as furniture. Products in storage of animal origin include, for example, hides, skins, and fur.The compositions of the invention can prevent adverse effects, such as rotting, decomposition, discoloration, fading, or mold formation. Microorganisms capable of degrading or altering industrial materials include, for example, bacteria, fungi, yeasts, algae, and slime molds. Compounds of formula (I) act preferentially against fungi, especially molds, discoloring fungi, and wood-destroying fungi (Ascomycetes, Basidiomycetes, Deuteromycetes, and Zygomycetes), and against slime molds and algae. Examples include microorganisms from the following genera: Alternaria, such as Alternaria tenuis; Aspergillus, such as Aspergillus niger; Chaetomium, such as Chaetomium globosum; Coniophora, such as Coniophora puetana; Lentinus, such as Lentinus tigrinus; Penicillium, such as Penicillium glaucum; Polyporus, such as Polyporus versicolor; Aureobasidium, such as Aureobasidium pullulans; and Sclerophoma, such as Sclerophoma pityophila. Trichoderma, such as Trichoderma viride; Ophiostoma spp., Ceratocystis spp., Humicola spp., Petriella spp., Trichurus spp., Coriolus spp., Gloeophyllum spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp., Cladosporium spp., Paecilomyces spp. Mucor spp., Escherichia, such as Escherichia coli; Pseudomonas, such as Pseudomonas aeruginosa; Staphylococcus, such as Staphylococcus aureus, Candida spp. and Saccharomyces spp., such as Saccharomyces cerevisae. Seed treatment The invention also includes a method for treating seeds. An additional aspect of the present invention relates in particular to seeds (dormant, barley, pre-germinated, or even with emerged roots and leaves) treated with a combination of compounds according to the invention or a composition comprising such combinations. The seeds of the invention are used in methods for protecting seeds and seedlings from harmful phytopathogenic fungi. In these methods, seed treated with the combination of compounds of the invention or a composition thereof is used. 237470 1336027 of 49 The combinations of compounds according to the invention and the compositions comprising such combinations are also suitable for the treatment of seeds and young seedlings. A large part of the damage to crops caused by harmful organisms is triggered by the infection of seeds before sowing or after germination. This phase is particularly critical since the roots and shoots of the growing plant are especially sensitive, and even small damage can result in the death of the plant. Consequently, there is great interest in protecting the seed and the germinating plant through the use of appropriate compositions. It is also desirable to optimize the amount of active ingredient used to provide the best possible protection to seeds, germinating plants, and emerged seedlings against phytopathogenic fungi, without harming the plants themselves with the active ingredient. In particular, seed treatment methods must also take into account the intrinsic phenotypes of transgenic plants to achieve optimal protection of the seed and germinating plant using a minimum of plant protection products. The present invention also relates to a method for protecting seeds, germinating plants, and emerged seedlings against attack by animal pests and / or harmful phytopathogenic microorganisms by treating the seeds with a combination or composition of the invention. The invention also relates to the use of the combinations or compositions according to the invention for treating seeds to protect them, germinating plants, and emerged seedlings against animal pests and / or phytopathogenic microorganisms. The invention further relates to seeds that have been treated with a combination or composition of the invention for protection against animal pests and / or phytopathogenic microorganisms. One of the benefits of the present invention is that treating seeds with these compositions not only protects the seed itself but also the resulting plants after emergence against animal pests and / or harmful phytopathogenic microorganisms. Thus, immediate treatment of the crop at sowing or shortly thereafter protects the plants, as does treating the seeds before sowing. It is also considered advantageous that the combination or composition of active ingredients of the invention can be used, especially for transgenic seeds, in which case the plant growing from this seed is capable of expressing a protein that acts against pests, herbicide damage, or abiotic stress. Treating such seeds with the active ingredients or compositions of the invention, for example, an insecticidal protein, can result in the control of certain pests. The combinations of compounds according to the invention and the compositions comprising such combinations are suitable for the protection of seeds of any plant variety used in agriculture, greenhouses, forestry, or horticulture. More specifically, the seeds are from cereals (such as wheat, barley, rye, millet, and oats), rapeseed, corn, cotton, soybeans, rice, potatoes, sunflowers, beans, coffee, beets (e.g., sugar and fodder beets), peanuts, and vegetables (such as tomatoes, cucumbers, onions, and 37 237470 1336027 of 49 lettuce), lawns and ornamental plants. The treatment of wheat, soybean, rapeseed, corn and rice seeds is particularly important. Furthermore, as described below, the treatment of transgenic seeds with the combinations of compounds or compositions of the invention is of particular importance. This refers to seeds of plants containing at least one heterologous gene that allows the expression of a polypeptide or protein, for example, with insecticidal properties. These heterologous genes in transgenic seeds may originate, for example, from microorganisms of the species Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus, or Gliocladium. These heterologous genes are preferably derived from Bacillus sp., in which case the gene product is effective against the European corn borer and / or the western corn rootworm. Particularly preferred, the heterologous genes are derived from Bacillus thuringiensis. In the context of the present invention, the combination or composition of the invention applies to seeds alone or in a suitable formulation. Preferably, the seed is treated in a state in which it is sufficiently stable so that no damage occurs during the treatment. Generally, the seeds can be treated at any time between harvest and some time after sowing. Typically, seeds that have been separated from the plant and ears, husks, stalks, rinds, hairs, or fruit pulp are used. For example, it is possible to use seeds that have been harvested, cleaned, and dried to a moisture content of less than 15% by weight.Alternatively, it is also possible to use seeds that, after drying, for example, have been treated with water and then dried again, or seeds immediately after priming, or seeds stored under primed conditions, or pre-germinated seeds, or seeds sown in nursery trays, tapes, or paper. When treating seeds, it is generally necessary to ensure that the amount of the combination or composition of the invention applied to the seed and / or the amount of additional additives is selected so that seed germination is not affected, or that the resulting plant is not damaged. This must be ensured especially in the case of active ingredients that may exhibit phytotoxic effects at certain application rates. The compound combinations according to the invention and the compositions comprising such combinations can be applied directly, i.e., without any other components and without dilution. Generally, it is preferable to apply the compositions to the seed in the form of a suitable formulation. Those skilled in the art are familiar with suitable formulations and methods for seed treatment. The compound combinations according to the invention can be converted into conventional formulations relevant for seed applications, such as solutions, emulsions, suspensions, powders, foams, aqueous pastes, or combined with other seed coating compositions, such as film-forming materials, granulating materials, fine iron or other metallic powders, granules, inactivated seed coating material, and also ULV formulations. 237470 1336027 of 49 These formulations are prepared in a known way, by mixing the active ingredients or combinations of active ingredients with conventional additives, such as, for example, common extenders and solvents or thinners, colorants, wetting agents, dispersants, emulsifiers, antifoams, preservatives, secondary thickeners, adhesives, gibberellins and also water. The colorants that may be present in the seed formulations that can be used according to the invention are all conventional colorants for such purposes. It is possible to use pigments, which are sparingly soluble in water, or dyes, which are soluble in water. Examples include dyes known by the names Rhodamine B, CI Pigment Red 112, and CI Solvent Red 1. The useful wetting agents that may be present in seed formulations usable according to the invention are all substances that promote wetting and are conventionally used in the formulation of agrochemically active ingredients. The use of alkylnaphthalenesulfonates, such as diisopropyl- or diisobutylnaphthalenesulfonates, is preferred. The useful dispersants and / or emulsifiers that may be present in the seed formulations usable according to the invention are all nonionic, anionic, and cationic dispersants conventionally used for formulating active agrochemical ingredients. The use of nonionic or anionic dispersants, or mixtures of nonionic or anionic dispersants, is preferred. Suitable nonionic dispersants include, in particular, ethylene oxide / propylene oxide block polymers, alkylphenol polyglycol ethers, and tristyrylphenol polyglycol ethers, and phosphated or sulfated derivatives thereof. Suitable anionic dispersants include, in particular, lignosulfonates, polyacrylic acid salts, and arylsulfonate / formaldehyde condensates. The antifoaming agents that may be present in the seed formulations usable according to the invention are all the foam-inhibiting substances conventionally used in the formulation of active agrochemical ingredients. The use of silicone and magnesium stearate antifoaming agents is preferred. The preservatives that may be present in seed formulations usable according to the invention are all substances that can be used for such purposes in agrochemical compositions. Examples include dichlorophene and benzyl alcohol hemiformal. The secondary thickeners that may be present in seed formulations usable according to the invention are all substances that can be used for such purposes in agrochemical compositions. Cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clays, and finely divided silica are preferred. The adhesives that may be present in the seed formulations usable according to the invention are all conventional binders that can be used in seed products. Polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, and tylose may be mentioned as preferred binders. 237470 1336027 of 49 The seed coating formulations according to the invention can be used to treat a wide variety of different seed types, either directly or after prior dilution with water. For example, the concentrates or preparations obtained from them by dilution with water can be used to coat cereal seeds, such as wheat, barley, rye, oats, and triticale, as well as corn, rice, rapeseed, pea, bean, cotton, sunflower, and beet seeds, or a wide variety of vegetable seeds. The seed coating formulations according to the invention, or diluted forms thereof, can also be used to coat transgenic plant seeds. In this case, additional synergistic effects can also occur in interaction with the expression-formed substances. For treating seeds with the seed formulations usable according to the invention, or preparations obtained from them by adding water, all mixing units commonly used for seed coating are suitable. Specifically, the seed coating procedure consists of placing the seeds in a mixer to add the desired quantity of the formulation, either as is or after prior dilution with water, and mixing until the formulation is evenly distributed over the seeds. If appropriate, a drying operation then follows. The application rate of the seed formulations usable according to the invention can vary widely. It is determined by the specific content of the active ingredients in the formulations and by the seeds themselves. The application rates of each active ingredient generally range from 0.001 to 50 g per kilogram of seed, such as from 0.01 to 15 g per kilogram of seed. Genetically Modified Organisms As mentioned, it is possible to treat all plants and parts thereof according to the invention. In a preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional methods of biological reproduction, such as crossing or protoplast fusion, and parts thereof, are treated. In a further preferred embodiment, transgenic plants and plant cultivars obtained by genetic engineering methods, if applicable in combination with conventional methods (genetically modified organisms), and parts thereof, are treated. The terms “parts” or “plant parts” or “parts of a plant” have been explained previously. Most preferably, plants of commercially available or currently used plant cultivars are treated according to the invention.Plant cultivars should be understood as plants that have new properties (“traits”) and that have been obtained through conventional breeding, mutagenesis, or recombinant DNA techniques. They can be cultivars, varieties, bio- or genotypes. The treatment method according to the invention can be used in the treatment of genetically modified organisms (GMOs), for example, plants or seeds. Genetically modified plants (or transgenic plants) are plants into which a heterologous gene has been stably integrated. 237470 1336027 of 49 genome. The term heterologous gene essentially refers to a gene that is provided or assembled outside the plant and, when introduced into the nuclear, chloroplast, or mitochondrial genome, gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other genes present in the plant (using, for example, antisense technology, cosuppression technology, RNA interference—RNAi technology—or microRNA—miRNA—technology). A heterologous gene found in the genome is also called a transgene. A transgene defined by its particular location in the plant genome is called a transformation or transgenic event. The plants and plant cultivars that are preferably treated according to the invention include all plants that have genetic material that imparts useful and particularly advantageous traits to these plants (whether obtained by breeding and / or biotechnological means). The plants and plant cultivars that are also preferably treated according to the invention are resistant to one or more biotic stresses, i.e., these plants exhibit better defense against animal and microbial pests, such as nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and / or viroids. The plants and plant cultivars that can also be treated according to the invention are those plants that are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, exposure to cold temperatures, exposure to heat, osmotic stress, flooding, increased soil salinity, increased exposure to minerals, exposure to ozone, high light exposure, limited availability of nitrogenous nutrients, limited availability of phosphorus nutrients, and shade avoidance. The plants and plant cultivars that can also be treated according to the invention are those plants characterized by improved performance characteristics. The increased yield in such plants may result from, for example, improved plant physiology, growth, and development, such as water use efficiency, water retention efficiency, improved nitrogen utilization, improved carbon assimilation, improved photosynthesis, increased germination efficiency, and accelerated ripening.Furthermore, yield can be affected by improved plant architecture (under both stressful and non-stressful conditions), which includes, among other aspects, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, number and spacing of internodes, root growth, seed size, fruit size, ear size, number of pods or ears, number of seeds per pod or ear, seed mass, improved seed filling, reduced seed dispersal, reduced pod dehiscence, and lodging resistance. Other yield traits include seed composition, such as the content and composition of carbohydrates (e.g., cottonseed or starch), protein content, oil content and composition, nutritional value, reduced antinutritional compounds, improved processability, and better storage stability. 237470 1336027 of 49 The plants that can be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor, resulting in generally higher yield, vigor, health, and resistance to biotic and abiotic stresses. The plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can be treated according to the invention are herbicide-tolerant plants, i.e., plants tolerant to one or more given herbicides. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that imparts such herbicide tolerance. The plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are insect-resistant transgenic plants, i.e., plants resistant to attack by certain target insects. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that imparts such insect resistance. The plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are tolerant to abiotic stress. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that imparts such stress resistance. Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention show alterations in the quantity, quality and / or storage stability of the harvested product and / or altered properties in specific ingredients of the harvested product. The plants or plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that imparts such altered fiber characteristics. The plants or plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are plants, such as rapeseed or related Brassica plants, with altered oil profile characteristics. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that imparts such altered oil profile characteristics. The plants or plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are plants, such as rapeseed or related Brassica plants, with altered seed dehiscence characteristics. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation. 237470 1336027 of 49 that imparts such altered seed dehiscence characteristics and include plants such as oilseed rapeseed plants with a delay or reduction of seed dehiscence. The plants or plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the invention are plants, such as tobacco plants, with altered post-translational protein modification patterns. Application When the combinations of compounds according to the invention and the compositions comprising such combinations are used as fungicides, the application rates can vary within a relatively wide range, depending on the type of application. The application rate, in the case of treating plant parts, for example leaves, is between 0.1 and 10,000 g / ha, preferably between 10 and 1,000 g / ha, more preferably between 50 and 300 g / ha (in the case of application by irrigation or drip irrigation, it is even possible to reduce the application rate, especially when using inert substrates such as rock wool or perlite); In the case of seed treatment: between 0.1 and 200 g per 100 kg of seeds, preferably between 1 and 150 g per 100 kg of seeds, with greater preference between 2.5 and 25 g per 100 kg of seeds, with even greater preference between 2.5 and 12.5 g per 100 kg of seeds; In the case of soil treatment: between 0.1 and 10,000 g / ha, preferably between 1 and 5,000 g / ha, where the quantities given refer to the total amount of active ingredient in the respective combination or composition. These application rates are merely illustrative and do not limit the scope of the invention. The invention is illustrated by the following examples. However, the invention is not limited to them. Examples The advanced fungicidal activity of the active compound combinations according to the invention is evident in the following examples. While the individual active compounds exhibit weaknesses with respect to fungicidal activity, the combinations have activity that surpasses a simple addition of activities. A synergistic effect of fungicides is always present when the fungicidal activity of combinations of active compounds exceeds the total activity of the active compounds when applied individually. The expected activity for a given combination of two active compounds is 237470 1336027 of 49 can be calculated as follows (see, Colby, SR, Calculating Synergistic and Antagonistic Responses of Herbicide Combinations, Weeds 1967, 15, 20-22): Yeah X is the efficacy when the active compound A is applied at an application rate of m ppm (og / ha), And it is the efficacy when the active compound B is applied at an application rate of n ppm (og / ha), and E is the efficacy when active compounds A and B are applied at application rates of myn ppm (og / ha), respectively, then X · Y E = X + Y-7X-L 100 For ternary mixtures, the following Colby equation results: Yeah X is the efficacy when the active compound A is applied at an application rate of m ppm (og / ha), And it is the effectiveness when the active compound B is applied at an application rate of n ppm (og / ha), Z is the efficacy when the active compound C is applied at an application rate of 0 ppm (og / ha), and E is the efficacy when active compounds A, B, and C are applied at application rates of m, nyo ppm (og / ha), respectively, then X · Y E = X + Y + Zt^—L 100 X · ZY · ZX · Y · Z ----1-100 100 100·100 The degree of effectiveness is indicated, expressed as a percentage. 0% means an effectiveness that corresponds to that of the control, while 100% effectiveness means that no disease is observed. If the actual fungicidal activity exceeds the calculated value, then the activity of the combination is superadditive, meaning there is a synergistic effect. In this case, the actual observed efficacy must be greater than the expected efficacy value (E) calculated using the formula mentioned above. Another way to demonstrate a synergistic effect is the Tammes method (see, “Isoboles, a graphic representation of synergism in pesticides” in Neth. J. Plant Path., 1964, 70, 73-80). 237470 1336027 of 49 Example A: In vitro assay with fungal microorganisms The wells of the 96-well microtiter plates are filled with 30 μL of a preparation of a test compound or combination of test compounds in methanol + alkylaryl polyglycol ether emulsifier. The solvent is then evaporated in a fume hood. In the next step, 200 μL of liquid growth medium, modified with an appropriate concentration of spores or mycelium suspension of the test fungus, is added to each well. Using a photometer, extinction is measured in all wells at a wavelength of 600 nm. Microtiter plates are incubated for 3 to 7 days at 20°C and 85% relative humidity. After incubation, growth inhibition is determined photometrically. Efficacy is calculated as a percentage of the untreated control; 0% efficacy means fungal growth as high as in the untreated control, while 100% efficacy means no fungal growth is measured. The tables below clearly demonstrate that the observed efficacy of the combination of active compounds according to the invention is greater than the calculated activity, i.e., a synergistic effect is observed. Table A: In-vitro assay with Botrytis cinerea (I-1) (ppm) Isoflucipram (ppm) (2.005) Fluopyram (ppm) (2.060) Cyclobutyluram (ppm) Ratio % of Efficacy Expected Colby Value % 0.1 0 0.04 0 20 99 0.8 86 0.16 68 0.1 0.04 20 1:0.4:200 99 99 0.1 0.04 0.8 1:0.4:8 90 86 0.1 0.04 0.16 1:0.4:1.6 71 68 0.5 9 0.1 0 0.02 9 0.2 85 0.04 0 0.008 49 5 30 0.5 0.2 5 1:0.4:10 98 91 0.1 0.04 5 1:0.4:50 98 30 0.02 0.008 5 1:0.4:250 99 68 237470 1336027 of 49 Table B: In-vitro assay with Cercospora beticola (I-1) (ppm) Isoflucipram (ppm) (2.019) Pidiflumetofen (ppm) Ratio % of Efficacy Expected Colby Value % 2.5 99 0.5 74 0.1 36 0.02 50 1 88 0.2 0 0.04 30 0.008 20 1 91 2.5 1 1 1:0.4:0.4 100 100 0.5 0.2 1 1:0.4:2 98 98 0.1 0.04 1 1:0.4:10 97 96 0.02 0.008 1 1:0.4:50 100 96 Table C: In-vitro assay with Diaporthe citri (I-1) (ppm) Isoflucipram (ppm) (2.005) Fluopyram (ppm) (2.019) Pidiflumetofen (ppm) Ratio % of Efficacy Expected Colby Value % 2.5 99 0.02 0 1 0 0.008 5 20 12 4 0 2.5 1 20 1:0.4:8 100 99 2.5 1 4 1:0.4:1.6 99 99 0.02 0.008 20 1:0.4:1000 23 16 0.02 0.008 4 1:0.4:200 10 5 2.5 99 0.5 90 0.02 0 1 9 0.2 15 0.008 0 0.2 0 2.5 1 0.2 1:0.4:0.08 99 99 237470 1336027 of 49 0.5 0.2 0.2 1:0.4:0.4 94 91 0.02 0.008 0.2 1:0.4:10 0 1 Table D: In-vitro assay with Fusarium culmorum (I-1) (ppm) Isoflucipram (ppm) (2.005) Fluopyram (ppm) (2.060) Cyclobutyluram (ppm) (2.019) Pidiflumetofen (ppm) Ratio % of Efficacy Expected Colby Value % 0.1 9 0.02 11 0.04 4 0.008 2 20 23 4 6 0.1 0.04 20 1:0.4:200 47 33 0.1 0.04 4 1:0.4:40 40 18 0.02 0.008 20 1:0.4:1000 56 33 0.02 0.008 4 1:0.4:200 26 18 0.5 15 0.1 9 0.02 11 0.2 0 0.04 4 0.008 2 0.2 44 0.5 0.2 0.2 1:0.4:0.4 63 53 0.1 0.04 0.2 1:0.4:2 54 51 0.02 0.008 0.2 1:0.4:10 47 52 0.5 0 0.1 0 0.2 11 0.04 0 0.2 38 0.04 34 0.008 7 0.5 0.2 0.2 1:0.4:0.4 50 44 0.5 0.2 0.04 1:0.4:0.08 40 41 0.5 0.2 0.008 1:0.4:0.016 21 17 0.1 0.04 0.2 1:0.4:2 42 38 0.1 0.04 0.04 1:0.4:0.4 43 34 0.1 0.04 0.008 1:0.4:0.08 17 7 237470 1336027 of 49 Table E: In-vitro assay with Parastagonospora nodorum (I-1) (ppm) Isoflucipram (ppm) (2.019) Pidiflumetofen (ppm) Ratio % of Efficacy Expected Colby Value % 2.5 100 0.1 87 0.02 0 1 82 0.04 49 0.008 69 1 86 2.5 1 1 1:0.4:0.4 100 100 0.1 0.04 1 1:0.4:10 100 99 0.02 0.008 1 1:0.4:50 100 96 237470 1336027 of 49 20225952036 CRISTIAN DANIEL BITTEL - 20225952036 Digitally signed by PORTALTRAMITES - INPI Date: 2021.04.12 16:26:53 -03:00 Reason: Digitally Signed by the INPI Location: Buenos Aires, Argentina 1336027
Claims
1. A combination of active compounds, characterized in that it comprises (A) as compound (A) methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, (B) as compound (B) isoflucipram, and (C) as compound (C) at least one additional active compound selected from (2.005) fluopyram, (2.019) pidiflumetofen, and (2.060) cyclobutryfluram. Thirteen claims follow.