Title - DEVICE FOR MIXING AT LEAST TWO COMPOUNDS AND MIXING METHOD

Abstract

The present invention relates to a mixing device for at least two compounds, such as a liquid and a powder, for obtaining bone cement, as well as to a method of mixing at least two compounds using said mixing device.

Description

“DEVICE FOR MIXING AT LEAST TWO COMPOUNDS” Designated Inventors: Giovanni Faccioli, Renzo Soffiatti TECHNICAL FIELD OF THE INVENTION The present invention relates to a mixing device for at least two compounds, such as a liquid and a powder, to obtain bone cement, as well as a method for mixing at least two compounds using such a mixing device. STATE OF THE ART Many types of liquid-powder mixers have been proposed for producing bone cement. Italian patent no. 1236864 as well as European patent no. 1912597, both in the name of the applicant of this patent application, teach a mixer comprising a first component delimiting a powder containment chamber, in which a second component defining a housing area for a vial containing a liquid to be mixed with the powder is slidably mounted. In the powder containment chamber, a rod supporting a mixing component is then slidably mounted, while on the internal end, in use, of the 2 0 second component is mounted a cap delimiting an annular groove for the housing of a gasket, the internal end of the cap delimiting a shoulder facing away from the containment chamber and intended to abut against a respective shoulder of the first component. With these devices, the vial is broken, the second component is manually displaced so that it escapes from the first component, thus causing the liquid from the broken vial to enter the powder containment chamber, and then the mixture is mixed inside the latter until the bone cement is obtained. If desired, a vacuum can be applied to the powder containment chamber while the second component is displaced to facilitate the transfer of the liquid into the latter. 1970369 of 45 With these devices it is very difficult to create a good seal in the dust containment chamber, given that the gasket, which must allow for manual movement of the second component with respect to the first, cannot be excessively hard or resistant. In this regard, during the mixing of powder and liquid, air may enter at the gasket and therefore form bubbles in the final bone cement mixture, which would obviously reduce the quality of the resulting bone cement. Furthermore, the devices discussed above have a volume of the first 10 components that is much larger than the vial, particularly depending on the configuration of the cap and the other components of the respective device. As can be understood, this results in an excessive final volume or width for devices according to the state of the art. A further mixing device provided by the prior art and described in European patent no. 3283206, also in the name of the applicant. This device comprises a first component and a second component in fluid communication with each other. The first component contains a first compound, and the second component has a vial inside it, which, in turn, contains a second compound to be mixed with the first compound. Means are then provided for breaking the vial so that the second compound can flow into the first component to mix with the first compound, thus obtaining a paste. This device has several disadvantages: the breaking of the vial, through the breaking devices, for the release of the second compound occurs by shattering the glass itself. This could cause glass fragments to settle in the passage holes used by the second compound to flow into the first component, effectively blocking these holes at least partially. In practice, the transfer of the second compound into the first component can be significantly complicated or at least accidentally slowed down. A further disadvantage comes from the fact that in case it was necessary to use more compounds to mix, and therefore more than one vial, it would be 1970369 de 45 consequently, an equal number of breaking devices are also necessary, in fact, increasing the costs and complexity of the manufacturing of the mixing device. Yet another disadvantage arises from the fact that the first component is made of opaque material which complicates the observation of the mixing state of the two compounds. There is therefore a need for a new type of device for mixing at least two compounds that overcomes the drawbacks of the known art. PURPOSES OF THE INVENTION The main aim of the present invention is therefore to improve the state of the art in the field of devices for mixing at least two compounds. Another object of the present invention is to provide a device for mixing at least two compounds that is easy to use. A further object of the present invention is to provide a device for mixing at least two compounds that has lower costs and structural complexity than the devices taught by the state of the art. Yet another purpose is to provide a mixing device that allows for rapid and efficient mixing of compounds. Another object of the present invention is to provide a mixing device capable of mitigating the possibility that, following the breakage of the containment elements of a compound, any fragments may hinder the mixing of the compounds and therefore the obtaining of the mixture. According to one aspect of the present invention, a device is provided for mixing at least two compounds to obtain a mixture according to claim 1. According to another aspect of the present invention, a method of mixing at least two compounds to obtain a mixture according to claim 25 is also provided. The dependent claims refer to preferred and advantageous forms of the invention. 1970369 of 45 BRIEF DESCRIPTION OF THE DRAWINGS Further features and advantages of the present invention will become more evident from the detailed description of some preferred embodiments of a device for mixing at least two compounds, illustrated by way of example, but not by way of limitation, in the attached drawings in which: - Figure 1 illustrates a perspective view of a mixing device for at least two compounds according to an embodiment of the present invention; - figures 2 and 3 illustrate respectively a front and side view of a component of the device of figure 1; - Figures 4 and 5 show enlarged details of the component in Figure 2; - Figures 6 to 9 illustrate respective sectional views of the second component of the device of Figure 1, - figure 10 shows a perspective view of the first component of the device of figure 1; - figure 11 shows a perspective view of the first component of figure 10 without the closing element; - Figure 12 illustrates a perspective view of the first component of Figure 10 with the locking means detached; - figure 13 illustrates a perspective view of the first component of figure 10 operationally associated with extrusion means; - Figure 14 illustrates the mixing device of Figure 1 in a bending operating configuration; - Figure 15 illustrates the mixing device of Figure 1 in a release operating configuration; - Figure 16 illustrates a top view of the connection end of the second component of the mixing device of Figure 1; - figure 17 shows a cross-section of the second component of figure 6; - figure 18 shows a front view of an enlarged detail of the device of figure 1; 1970369 of 45 - figure 19 shows a side view of an enlarged and exploded detail of the device of figure 1; - figure 20 shows a detail in enlarged scale and longitudinal section of the device of figure 1; - Figure 21 is a schematic longitudinal sectional view of another embodiment of the second component for a device according to the present invention; - Figure 22 is a schematic cross-sectional view of the second component of Figure 21, and - Figure 23 is another schematic longitudinal section view of a further embodiment of the second component for a device according to the present invention, - Figure 24 shows a perspective view of a further embodiment of the second component for a device according to the present invention, - Figures 25 and 26 illustrate the second component of Figure 24 with clamping means. In the attached drawings, identical parts or components are identified by the same reference numbers. 0 EXAMPLES OF REALIZATION OF THE INVENTION With reference to the attached figures, the reference number 1 indicates a device according to the present invention for mixing at least two compounds C1, C2 to obtain a mixture M. The at least two compounds C1, C2 could be respectively a powder 2 5 C1, such as one or more polymers, possibly acrylic, and a liquid C2, such as a monomer, to obtain bone cement M, for example for medical uses, or an acrylic resin M. More specifically, the powder could also be inorganic based on Calcium Salts, such as Calcium Sulphate (gypsum) or mixtures of Tricalcium Phosphate (TCP) or 3 0 Hydroxyapatite (HA) or mixtures based on Calcium Oxides (CaO), Magnesium Oxides 1970369 de 45 (MgO), Aluminum Oxides (Al2O3), Silicon Oxides (SiO2), Iron Oxides (Fe2Ü3) and / or other complex salts such as Calcium Metasilicate (CaSiO3 and Ca2Si2O5) and / or Tricalcium Aluminate Ca3(AlO3)2 and / or Tetracalcium Ferrite Aluminate (C4AlFe) and / or other inorganic compounds which, combined with a second C2 compound, such as pure water or an aqueous solution containing inorganic salts synergistic with those present in the powder, give rise to a hardening mass commonly identifiable as “hydraulic cement”. Preferably, all compounds will have a degree of purity such that the mixture M gives rise to a biocompatible product or mixture. The mixing device 1 comprises a first component 2 including a first body 2a, preferably of substantially tubular configuration at least in correspondence with a respective side wall, which defines a first housing area HA1 for at least a first compound C1 and a second component 3, in use, operationally associable, for example through a threaded, bayonet, forced coupling or other type, to the first component 2 so as to place the first and second components 2, 3 or the respective housing areas HA1, HA2 in fluid communication defining an axis or a direction of transfer AD of fluid from the first 2 to the second 3 component. With reference to the device illustrated in figure 1, the transfer axis or direction AD is substantially vertical or in any case substantially parallel to the main development axis of the first 2 and second 3 components or of their respective tubular side walls or in any case in the direction from the first 2 to the second 3 component, even slightly inclined with respect to the main development axes of the latter. Clearly, it would also be possible to have two components 2, 3 constrained and inclined with respect to each other, in which case the transfer axis or direction AD could also be inclined with respect to the main development axis of one or both components 2, 3, but in any case the axis or direction AD defines the main axis or direction along which the fluid passes between the two components 2, 3. In particular, the second component 3 comprises a second body 3a, made of flexible or deformable material, elastic or plastic if desired, i.e. 1970369 de 45 elásticamente o plásticamente deformable, the second component 3 defining a second housing zone HA2 for at least one second compound C2. Advantageously, the second component 3 is completely or partially translucent or transparent. The material used to make the second body 3a can be any suitable one, preferably thermoplastic polyurethane or TPU. Clearly, the chemical composition of the second body 3a must be such that it does not absorb the second compound C2. Furthermore, in the case in which the second body 3a is totally or partially translucent or transparent, as schematically shown in figures 2 and 3, it allows to observe in detail what happens inside the second body 3a during the transfer process of the at least one second compound C2 from the second housing area HA2 to the first housing area HA1, thus giving, for example, the operator responsible for obtaining the mixture M, a high level of control over this process. As regards the configuration of the second body 3a, with reference to the non-limiting embodiment illustrated in the figures, it comprises a tubular side wall with a constraint or connection end 3b, for example internally threaded to the first component 2, which is open and defines the passage opening from the second HA2 to the first HA1 housing area. The constraint or connection end 3b may be tubular and define the continuation of the side wall of the second body 3a. The tubular wall preferably has a variable cross-section from one end to the other. If desired, the second body 3a is also provided with a distal wall 3a1, used by the first component 2 to close the respective second housing area HA2. Preferably but not necessarily, the second body 3 is made in one piece. As for the thickness of the second body 3 it is preferably but not necessarily constant. 1970369 of 45 The first body 2a can be laterally tubular with both its ends 2b, 2c open, tubular or annular if desired, or even with only one end open, i.e. the connecting end 2c to the second component 3. Preferably, the first body 2a is made in one piece. The first body 2a can advantageously be made of plastic or composite material or of another material, preferably also translucent or transparent, if desired also of glass or similar materials, in order to allow the inside of the first housing area HA1 to be observed and therefore to have greater control during the mixing of the at least two compounds C1, C2 and the subsequent formation of the mixture M. The mixing device 1 then comprises at least one containment element 4 of the at least one second compound C2, positioned or positionable within the second housing zone HA2, which may comprise or delimit at least one breaking zone or point or opening BZ of the same. It should be noted that the term “breaking or opening zone or point” means an area or point of the containment element 4 which, when subjected to a specific external pressure or to the action of a specific perforator, allows a rapid and preferably clean, i.e. non-fragmented, breaking or opening of the containment element 4 in that specific area or point. The at least one containment element 4 may be at least one vial, for example two or more vials, possibly made of glass or similar material, as shown in the non-limiting embodiment of the present invention in figure 1. Preferably, the at least one containment element 4 comprises at least one containment portion of the at least one second compound C2 with for example a cylindrical body 4a and at least one pointed portion 4b, possibly designed to abut or rest against the second body 3a for the opening or breaking of the containment element 4. As regards the breaking point or opening area BZ, it can advantageously be delimited by a narrowing 4c placed between the cylindrical body 4a and the pointed portion, possibly abutting 4b. Clearly, it could 1970369 de 45 even if no narrowing 4c is foreseen, the vial 4 may not necessarily break at this point. Alternatively, the vial 4 could have a containing body, for example made of glass, delimiting an (open) end at which a cap component is provided mounted to close that end, so as to guarantee the sealing of the vial and prevent the unwanted leakage of the second compound from it; in this regard, the cap component or a film thereof is impermeable to the second compound. In this case, the cap component can, for example, be fixed in place on the containment body by means of a ring or similar, for example made of aluminum, which can be annular. The cap component, or rather a part thereof, can be pierced; in this regard, the cap component can have a support body, for example annular, on one side, for internal use (inside the vial 4), to which a film impermeable to the second compound is attached and pierceable by means of breaking or opening the vial. Such a vial could be opened by a needle or piercer or even by a portion or element, for example a pointed part of the device. It should be noted that reference has been made to "at least one containment element 4 of at least one second compound C2", but two, even three, four, or more containment elements 4 could be envisaged, each containing a quantity of compound C2 or each containing different types and / or quantities of compounds. Naturally, in general, it is expected that the number of containment elements 4 positioned within the second housing zone HA2 is reasonably compatible with the dimensions of the second body 3a. In relation to the above, the containment element 4 is movable or tiltable transversally or orthogonally to the axis or direction of transfer AD between a first rest position (see figure 1) in which a respective portion of the abutment 4b is not in contact with or pushed such as to cause its breakage or opening against the second component 3 or with elements of the device integral with it and at least a second position (see figure 14) of breakage or opening in which the containment element 1970369 of 45 containment 4 or one or more respective portions of the abutment 4b hits / hits against the second component 3 or presses against it (against a respective internal portion) or against an element of the device integral with it to a greater extent than in the first position. With specific reference to the rest position, the second component 3 or a respective portion of the abutment 4b may therefore not be in contact with other elements (second component 3) of the device or may even be in contact with them, but not in a push on them or in any case in a push not such as to cause the breakage or opening of the containment element 4. In the transition from the first to the second position, following the impact, the containment element 4 breaks or opens such that the second compound C2 inside it can exit the containment element 4 and pass or flow from the second housing region HA2 to the first housing region HA1 along the axis or direction of fluid transfer AD. This transition can be achieved by gravity, by placing the second component 3 in a position above the first component 2 and / or by pressurizing or pumping the second component 3 or, if desired, by suction at the first component 2. With reference to the expression transversely or orthogonally to the axis or direction of transfer AD, it has been observed that the direction of transfer AD is a direction of passage from the second HA2 to the first HA1 zone, therefore a zone of approach to the first component 2 from the second HA2, which, with reference for example to figure 1, is a de facto vertical axis or direction. Therefore, the fact that the containment element 4 is movable or tiltable transversely or orthogonally to the axis or direction of transfer AD, implies that the containment element 4 is broken or opened if it is moved at least in part along a direction other than that of transfer AD. In essence, the containment element 4, to be opened or broken, is not pushed, as happens according to the state of the prior art, towards the first component, but is tilted, from one side to the other, or moved horizontally or orthogonally or transversally with respect to the axis or direction AD, so as to bring a 1970369 of 45 respective abutment portion, in contact or impact against specific portions of the second component 3 or even against protruding portions or elements, preferably internally of the device 1 and if desired in one piece with the second component 3. Clearly, the direction of movement or inclination of the containment element 4 can also include (but not only) a component of approach to the first component 2. In this regard, it is clearly important that the containment element 4 is displaced relative to the component or element of the device on or against which it is to impact or contact, such as for example a respective portion 3e of the second component 3 or of an element integral with it. Preferably, as partly indicated, the second component 3 has a constraint or connection end 3b to the first component 2 defining or developing around the axis or direction of fluid transfer AD and at least one projecting section (consisting of one or more portions or sections 3c, 3d, 3f of the respective tubular wall) from the first end 3b, which projecting section is tiltable or bendable with respect to the axis or direction of fluid transfer AD, so that determining the inclination or bending of the projecting section with respect to the first end 3b causes the inclination of the containment element 4 mounted within the second component 3 and therefore the passage of the same between the first and at least one second position and the respective breaking or opening of the same. In this regard, the containment element 4 is preferably mounted within the second component 3 and is integral in movement or inclination with it or better with the at least one respective projecting section 3c, 3d, 3f. Preferably, the second component 3 has, from one end to the other, several tubular sections, one with a different section from the others, designed to internally define a specific face or internal surface defining the second housing area HA2 and, if clearly desired, also a corresponding external configuration. In this regard, one, two or more sections 3c, 3d of the second retaining component 3 of the containment element 4 may be provided, which section or sections 3c, 3d are intended to tighten or enclose or engage a respective part of the element. 1970369 de 45 of containment 4 so as to keep it in a specific position relative to another component of the device, for example at a distance from the connection end 3b or in any case with a respective portion of confirmation or abutment 4b in a specific internal area defined by the component 3. A portion 3e may then be provided for accommodating a slack or play in a respective abutment portion 4b, for example the tip of the containment element 4, which portion 3e is preferably proximal, in use, to the first component 2 or in any case adjacent and subsequent to the constraint end 3b of the second component 3 to the latter. Clearly, the maintenance of the abutment portion 4b in the zone or area defined by the portion 3e is specifically delegated to the presence of one or more retaining portions 3c, 3d. Moreover, the containment element 4 is preferably not integral in its movement or inclination with the accommodating portion 3e, so that the accommodating element can be moved or inclined with respect to the latter. The retaining sections 3c, 3d can have any suitable cross-section, for example ellipsoidal or rectangular (with rounded edges if desired), with one or more intermediate narrowings if desired. The reception section 3e can have any suitable cross-section, for example ellipsoidal or rectangular (with rounded edges if desired), or without one or more constrictions if desired. With reference to this, each retaining section 3 c, 3d can be defined internally by respective projections or protuberances or recesses 3c1, 3d1 designed to engage, for example to measure, if desired with the possibility of sliding following an appropriate push, a respective portion of the containment element 4. Clearly, the internal face of the sections 3 c, 3d could be configured as the entire perimeter of a tubular body of the containment element 4, so as to engage the latter completely from the perimeter or they could be such as to engage only portions of the circumference of the tubular body of the containment element 4. The section of reception 3e with slack can instead have an internal section considerably larger than the containment element 4 or the respective elements of 1970369 de 45 containment of a tip 4b of the same or of the same, for example greater than 3 / 4 or 3 / 2 of the volume of such tip or tips 4b, even three, four, five or more times greater than the volume of the latter and in any case the portion 4b of the containment elements 4 arranged within the area or zone defined by the reception section 3e is not clamped by the latter and is free to move or tilt in the passage from the first to the second position, for example until it abuts against a portion of the internal surface of the section 3e or another component of the device 1. The second component 3 may then include, if desired, adjacent to and following a retention section or between two possible retention sections 3c, 3d, a pumping section 3f, which will be discussed in more detail later. The pumping section 3f may have any suitable cross-section, for example circular or ellipsoidal, with a variable diameter or cross-section, for example first increasing and then decreasing, approaching the connection end 3b. With reference to the description of the second component 3 now reported, the at least one protruding section that can be tilted or folded with respect to the axis or direction of fluid transfer AD and is preferably constituted by the at least one retaining section 3c, 3d and by the pumping section 3f, while the receiving section 3e, in the passage from the first to the second position, remains substantially integral with the constraint or connection end 3b, although it could move slightly. With reference to the non-limiting embodiment illustrated in the figures, two containment elements or vials 4 are provided, and the internal surface 3a of the second component 3 is configured in such a way as to retain, for example side by side, if desired with a space between them, the two or more containment elements 4. In this regard, one or more of the sections of the second component 3 could internally define projections or protuberances or recesses intended to effectively separate the positioning area of ​​each containment element 4. Preferably, any containment elements 4 would then be movable or tiltable together or simultaneously, by acting on them or externally on the second component 3. Advantageously, the second component 3 comprises folding means 5 1970369 of 45 configured to allow or facilitate the folding of at least one portion or section 3c, 3d, 3f of the second body 3a from the first to the second position, in correspondence with said folding means 5, so as to cause the breaking of the at least one containment element 4, if desired of the narrowing 4c in correspondence with or in the vicinity of the breaking zone or point BZ so that the at least one second compound C2, in use, passes or flows (or rather can pass or flow) from the second housing zone HA2 to the first housing zone HA1. It should be noted that, during the present discussion, the bending or non-bending of any component of the mixing device 1 is to be considered with reference to the usual pressure ranges to which the same can be subjected during the operations for obtaining the mixture M, such as for example the bending force of an operator or the bending force pre-established by an automatic system designed to carry out the operations necessary for obtaining the mixture M. Preferably, the bending means 5 are or comprise at least one weakening element or portion 6, for example at least one depression or hollow, delimited in the second body 3a so that, following the bending of the latter or respective sections, it bends in correspondence with the at least one weakening element or portion 6 to cause the breakage of the at least one containment element 4 or, more specifically, of the narrowing 4c in 0 correspondence or in the vicinity of the BZ breaking point or zone. According to the non-limiting embodiment of the present invention shown in the figures, the at least one weakening element or portion 6 is constituted by two, three, four or more depressions 6 delimited in the second body 3 and positioned staggered with respect to each other, possibly two by two, one on the opposite side to the other with respect to a plane of 5 longitudinal section of this second body 3 a. Such depressions 6 can be foreseen or appear in correspondence with the reception section 3e or better between a retention section 3d and the reception section 3e. Moreover, the second component 3 or, more specifically, the second body 3a can 0 advantageously comprise, as for example shown in figure 24, an element 1970369 de 45 or bellows section 3i arranged between the retaining section 3d and the receiving section 3e, if desired, arranged in proximity to the folding means 5, if provided. This element or bellows section 3i is designed to facilitate the folding of the second body 3a so as to simplify or in any case improve the process of obtaining the mixture M. The second component 3 or, more specifically, the second body 3a can advantageously also comprise or delimit one or more stiffening elements or sections 7, preferably extending along a longitudinal direction xx of the second component 3 and configured to stiffen the second body 3a so that the latter, in use, does not bend in correspondence with such one or more stiffening elements or sections 7. According to the non-limiting embodiment of the present invention shown in the figures, a stiffening element or portion 7 is provided, which extends along a longitudinal direction xx of the second body 3a, in proximity to each bending means 5 or, more specifically, to each weakening element or portion 6 or even more specifically to each depression 6. Such stiffening sections 7 can be foreseen or abut one or more retaining sections 3c, 3d. Preferably, the second component 3 also comprises pumping means 8 configured, in use, to expedite the release or otherwise facilitate the transfer of the at least one second compound C2 from the at least one containment element 4 to the second housing region HA2 once the containment element 4 has been ruptured or opened. The pumping means 8 may advantageously be or comprise one or more enlarged or balloon-shaped or raised portions 8a delimited in the second body 3a, optionally presenting one or more shapes 8b, for example annular. According to the non-limiting embodiment of the present invention shown in the figures, the pumping means 8 consists of one, two or more enlarged or balloon-shaped portions 8a delimited in the second body 3a. With reference to the non-limiting construction element illustrated in the figures, the pumping section 3f actually defines the pumping means 8. 1970369 of 45 In this regard, the pumping section 3f has at least two main sections 3f1, 3f2 opposed to each other at a distance greater than the width of a respective containment element 4, so that a pumping area PA is present between the latter and the two main sections 3f1, 3f2 once the at least one containment element 4 is housed in the second housing area HA2. If desired, the pumping section 3f, considering the respective perimeter, also has one or two lateral sections 3f3, 3f4 connecting the two first sections 3f1, 3f2 and which are at a distance from each other equal to the width of the containment elements 4 (one, two or more) provided in the device, with the possible interposition of projections or protuberances or recesses. In this regard, the pumping section 3f can also have a circular configuration, whereby the various sections 3f1-3f4 are equidistant from a respective centre, but the containment elements 4 are mounted side by side, so that each has a respective end close to a portion or section 3f3, 3f4 of the pumping section 3f, but with at least one respective space or pumping area between the containment elements 4 and other portions or sections 3f1, 3f2 of the pumping section 3f. In essence, the containment element 4, in the pumping section 3f, is, in the rest or non-pumping condition of the latter, not in contact with at least one and preferably with both of the two main sections 3f1, 3f2 and, if foreseen, in contact or in any case close to the two lateral sections 3f3, 3f4. In particular, it is possible, following the pressure and subsequent release of the pumping means 8 and more specifically of the second body 3a in correspondence with one or both of the main sections 3f1, 3f2, to increase and subsequently decrease the air pressure in the second housing area HA2 and therefore, of the air in the part of the latter housing the breaking area or point BZ so as to accelerate the release of the at least one second compound C2 contained in the at least one containment element 4 or in any case facilitate the transfer of the at least one second compound C2 from the at least one containment element 4 to the second housing area HA2, clearly after the at least one containment element 4 has been broken or opened. 1970369 of 45 In essence, since air is a compressible fluid, the pressure and the subsequent release of the pumping means 8 cyclically decreases and increases the volume of the air present inside the second housing area HA2, generating an alternating increase and decrease in pressure in the latter, thus determining a faster emptying of the containment element 4 and the more sudden passage of the respective second compound 2 into the first housing area HA1. It should be noted that, in the case in which the second component 3 includes pumping means 8 or, more specifically, one or more enlarged or balloon-shaped portions 8a, the one or more stiffening elements or sections 7, if provided, may interrupt in correspondence with such pumping means 8 and then continue or in any case continue to develop, for example along the same longitudinal direction xx. As regards the positioning of the at least one containment element 4 within the second housing area HA2, the second component 3, or more specifically, the second body 3 a can advantageously delimit, depending on the configuration of the internal face, in particular in correspondence with the retaining section or sections 3 c, 3d, at least one positioning seat PS configured to support the at least one containment element 4. Preferably, the at least one containment element 4 is engaged in the at least one positioning seat PS by forced or custom-fit coupling, so that it is not necessary to use separate or specific support means, such as springs or similar, for the at least one containment element 4 separate from the second body 3 a. In practice, the at least one containment element 4 can be engaged in the at least one positioning seat PS which, thanks to its particular configuration, is able to self-support it without using additional components. In relation to this aspect, the at least one containment element 4 is supported at a distance from the engagement area between the first 2 and second 3 components, so that the respective tip 4b results, for example in the receiving section 3e, with slack. As indicated above, the second component 3 can then advantageously 1970369 de 45 comprising or delimiting a constraint or connection end 3b, for example internally threaded or for bayonet or coupling constraint to the first component 2. In particular, such constraint or connection end 3b defines at least one through opening TO so as to allow, in use, the passage or transfer of the at least one second compound C2 from the second housing area HA2 to the first housing area HA1. Furthermore, in the wall section 9 of the second component 3 which in fact defines the slack or play-bearing section 3e and which is, if desired, adjacent to the constraint or connection end 3b, the second component 3 preferably comprises or delimits reinforcement elements or sections 9a configured to reinforce this wall section 9 so that, in use, it does not bend. Advantageously, the second body 3a has stiffeners such as to control any bending of the latter not at the same level, but for example at the level of any bending means 5 or more specifically, of the at least one weakening element or portion 6. The device 1 may also comprise one or more retaining elements 3h at the end 3b, which retaining elements 3h are for example positioned at the at least one through opening TO, and are configured to retain, in use, the broken parts of the at least one retaining element 4 within the second housing region HA2. The one or more retaining elements 3h, according to the non-limiting embodiment shown in figure 16, are a cross element 3h1, but clearly in other embodiments they could also be a net or grid-shaped element. Advantageously, a filter 3g is also provided to intercept the opening or passageway TO delimited by the connection end 3b of the second component 3, which can serve, among other things, to prevent the second compound from passing backwards from the first HA1 to the second HA2 housing area. Advantageously but not necessarily, the breakage of the at least one containment element 4 preferably occurs by a substantially clean cut so that 1970369 de 45 no fragments are released that could accidentally obstruct the passage from the second HA2 to the first HA1 housing area and ruin the obtaining of the M mixture. It should be noted that the constraint or connection end 3b can be made either in one piece with the second body 3a, or also separately and subsequently connected irremovably or not to the second body 3a. In this regard, see for example the non-limiting embodiment of the second component 3 shown in figure 24, in which the wall section 9 is illustrated as a single piece with the second body 3a, while the constraint or connection end 3b, or in any case the component or portion constituted by it, can be removably constrained, for example by forced coupling, screwing, bayonet engagement or in any case by means of a suitable removable constraint, to this wall section 9. In this regard, this could for example allow the use of different constraint or connection ends 3b to adapt, if necessary, the constraint or connection of the second component 3 to the possible dimensions or measurements of the connection end 2c of the first component 2. According to the non-limiting embodiment illustrated in the figures, the constraint or connection end 3b comprises a section with annular shank, optionally externally threaded, rising from a base section which can be constrained (in any suitable way) to the wall section 9, which section with annular shank is designed to engage the connection end 2c by screwing or interlocking or in another suitable way. In relation to this aspect, safety clamping means 26a, 26b of the constraint or connection end 3b to the wall section 9 could also be provided, designed to preferably removably constrain these components. The clamping means, if provided, may include for example a locking ring, optionally but not necessarily made with two C-shaped or jaw-shaped components 26a, 26b that can be removably locked together at their respective free ends. With reference to this aspect, the ends of the two C-shaped or jaw-shaped components can be engaged in any suitable manner, such as interlocking, coupling or by means of constraint between one or more teeth on the ends of a 1970369 of 45 component 26a and / or one or more holes or slots on the ends of the other component 26b. As will be understood, to safely tighten the constraint or connection end 3b to the wall section 9, once these components have been assembled, they will be engaged by means of the clamping means 26a, 26b, for example by enclosing part 5 of the assembled components 3b, 9 with the two C-shaped or jaw-shaped components 26a, 26b, which will then be engaged as indicated above at their respective ends and positioned on opposite sides with respect to the assembled components 3b, 9. Thanks to the safety clamping means 26a, 26b it is therefore possible to prevent the unwanted separation of the two parts 3b and 9, obviously in the case that they are not 10 in a single piece. Always with reference to the non-limiting embodiment illustrated in the figures, the second component 3 operationally associated, in use, with the first component 2 preferably comprises at least three operational configurations RC, FC, REC. The at least three operating configurations RC, FC, REC comprise at least one 15 rest operating configuration RC in which the second body 3a is not bent and the at least one containment element 4 is not broken, at least one bending operating configuration FC in which the second body 3a is bent, if desired in correspondence with the bending means 5 and the at least one containment element 4 abuts the second body 3a thus causing the breakage of the at least one containment element 4 or, more specifically, of the constriction 4c, in correspondence with or in the vicinity of the breaking zone or point BZ and at least one release operating configuration REC in which the second body 3a is not bent or is bent less than the bending configuration FC and the at least one containment element 4 or, more specifically, the constriction 4c,and broken at or near the 2 5 breaking point zone BZ so as to permit release of the at least one second compound C2 into the second housing zone HA2., In particular, in the case in which the at least one containment element 4 advantageously comprises at least one containment portion 4a of the at least one second compound C2 and at least one abutment portion 4b with the second body 3a, in the 3 0 bending operating configuration FC, the bending of the second body 3a, if desired 1970369 of 45 correspondence of the bending means 5 or, advantageously, of the at least one weakening element or portion 6, brings the abutment portion 4b into contact with the second body 3 ao, more specifically with the reception section 3e, and the pressure generated by this abutment determines the breakage of the at least one containment element 4 or, more specifically, of the constriction 4c, in correspondence with or in the vicinity of the breaking zone or point BZ. Thus, for example, with particular reference to the non-limiting embodiment shown in figure 14, the bending of the second body 3a by the operator, for example in correspondence with the weakening portions 6, brings each pointed portion 4b of the two vials 4 closer to and abuts the inside of the reception section 3e, and the pressure generated by this abutment causes each vial 4 to break in correspondence with or in the vicinity of the breaking zone or point BZ, for example delimited by a constriction 4c placed between the cylindrical body 4a and the pointed portion 4b. As can be understood, this breaking of the at least one containment element 4 allows a clean cut of the same, thus avoiding its fragmentation. As regards the REC release operational configuration, with reference by way of example and not limitation to figure 15, it is possible to speed up the release of the at least one second compound C2 from the vials 4, or in any case facilitate its transfer from the second housing area HA2 to the first housing area HA1, using the pumping means 8 or, more specifically, the one or more enlarged or balloon-shaped portions 8a delimited in the second body 3a. In this regard, the operator may consecutively press and release the pumping means 8 or, more specifically, the one or more enlarged or balloon-shaped portions 8a until the vials 4 have released all of the at least one second compound C2 into the second housing region HA2. As regards, instead, the first component 2, it preferably comprises mixing means 10 configured, in use, to mix the at least one first compound C1 with the at least one second compound C2. In particular, the mixing means 10 may advantageously comprise 1970369 de 45 at least one handle component 11, a stem 12 including a first end 12a connected to the handle component 11 and a second end 12b, as well as a mixing component or rotor 13, connected to or supported by the second end 12b of the stem 12, intended, in use, to be translated and / or rotated within 5 of the first housing region HA1 for mixing the at least two compounds C1, C2. In more detail, the mixing component 13 can be connected to the stem 12 through a removable or non-removable engagement, for example through a bayonet or screw engagement or similar so that, as will be seen better below, it can be easily released from the stem 12, although this is not necessary. According to the non-limiting embodiment of the present invention shown in the figures, the mixing component 13 may define a plurality of leaf portions 13a extending from a central region CZ thereof. In this regard, each leaf portion 13a can advantageously delimit a respective through hole TH which, together with the configuration of the leaf portion 13a, is designed, in use, to improve the mixing of the mixture M. As can be understood, this particular configuration of the mixing component 13 allows for efficient mixing of the at least two compounds C1, C2. Clearly, this configuration is purely illustrative and not limiting. 0 The first component 2 preferably also comprises a push component or piston 14, slidably mounted in the first housing region HA1, and configured, in use, to push or press the mixture M out of the first housing region HA1, and means 15 for locking such push component 14 at an end of the first component 2 distal, in use, from the second component 3. In essence, the locking means 15 can advantageously define with the at least one thrust component 14 at least two operating positions RD, TD. Such at least two operating arrangements RD, TD comprise at least one rest or locking operating arrangement RD in which the locking means 15 are operatively associated with the thrust component 14 for locking the latter 3 0 which is not able to slide in the first housing area HA1 and at least one 1970369 de 45 release or push operating arrangement TD wherein the locking means 15 are not operatively associated with the push component 14 which, in use, is capable of sliding and being pushed into the first housing region HA1. As regards the locking means 15, they may be or comprise a locking body 16 including at least one component or an engaging or housing portion 16a while the at least one thrust component 14 may comprise a base body 14a including at least one groove or projection 14b intended to house the component or the engaging portion 16a or be engaged in the component or housing portion 16a of the locking means 15. In particular, the component or engagement portion 16a may have, for example, a substantially C- or U-shaped plan configuration. According to the non-limiting embodiment of the present invention shown in the figures, the engagement portion 16a of the locking means 15 has a substantially C-shaped plan configuration and is removably engaged or engageable in a respective groove 14b of the thrust component 14. Furthermore, the first body 2a may comprise a flanged or enlarged end 2b opposite the connecting end 2c. In such a case, the locking means 15 may advantageously comprise, on the one hand, in use, proximal to the connecting end 2c, a first main wall section 16b, a side wall 16c which connects the first main wall section 16b to a second main wall section, which internally defines the engagement or housing portion 16a and defines with them a coupling zone IZ for at least part of the enlarged end 2b of the first body 2a. If desired, the locking body 16 may also comprise or delimit a first end wall 16d, for example rising from the first section of the main wall 16b in a direction away from the engagement area IZ, and configured, in use, to envelop part of the first body 2a and / or a second end wall 16e, for example rising from the component or portion of engagement or housing 16a in a direction away from the engagement area IZ, and configured, in use, to envelop at least part of the thrust component 14. 1970369 of 45 More specifically, with reference to the longitudinal axis of the first component 2, the locking means 15 are removably engageable with the first main wall section 16b and the second main wall section orthogonal to the axis xx and the side wall 16c coaxial to the axis xx. In essence, the locking means 15 or, more specifically, the locking body 16, can advantageously be removed from the thrust component 14 to make the latter pass from the rest operating configuration RD to the thrust operating configuration TD or, conversely, it can be operationally associated or, more specifically, engaged or housed at least partially in the thrust component 14 to make the latter pass from the thrust operating configuration TD to the rest operating configuration RD. This movement or passage is obtained by relatively moving the first component of the locking means 15 in a direction transverse or orthogonal to the axis xx. In essence, to release or constrain the locking means 15 and therefore the thrust component 14, it is sufficient to move the locking means 15 transversely or orthogonally to the axis xx, so as to determine the disengagement or engagement between the groove or projection 14b and the component or the engaging portion 16a. As can be understood, in the rest operating configuration RD the particular configuration of the locking means 15 or, more specifically, of the locking body 16 prevents the thrust component 14 from sliding in the first housing area HA1, thus ensuring notable stability and sealing, for example during the mixing operations of the at least two compounds C1, C2 but also during the bending operations of the second body 3 and, if desired, also during the pumping operations of the second compound C2 in the second housing area HA2. Going into more detail about the exemplary and non-limiting configuration of the thrust component 14, it preferably delimits a through channel TC which defines at least two operating positions MP, CP for the mixing means 10. These at least two operating positions MP, CP include at least one mixing operating position MP in which the stem 12 is slidably inserted into the through channel TC and at least one closing operating position CP in which the stem 12 is 1970369 de 45 extracted from said through-channel TC and the mixing component 13 and inserted, for example to size or by screwing or by bayonet engagement, into the through-channel TC. In essence, during the mixing of the at least two compounds C1, C2 present inside the first housing area HA1, the mixing means 10 are in the mixing operating position MP so that it is possible, for example for the operator, to grip the handle component 11 and slide the stem 12 inserted in the through channel TC so as to mix the at least two compounds C1, C2 through the mixing component 13 in order to obtain the mixture M. Once mixing has been performed, the operator can move the mixing means 10 from the mixing operating position MP to the closing operating position CP, by extracting the stem 12 from the through channel TC, if desired up to the end of its travel, and subsequently rotating the handle component 11, for example in an anticlockwise direction, so as to release the stem 12 or rather the end 12b thereof from the mixing component 13 removably engaged with it. In this way, the mixing component 13 remains advantageously engaged, for example by fitting or by screwing or by bayonet engagement, in the through-channel TC, thus ensuring the fluid-tightness of the first housing region HA1. Preferably, the first component 2 or, more specifically, the first body 2a 2 0 comprises a connecting end 2c, in use, proximal to the second component 3, for example a threaded end, and at least one closing cap 18 configured, in use, to be operatively associated, for example by screwing, to such end 2c so as to close the first body 2a. According to the non-limiting embodiment of the present invention 25 shown in figure 1, the second component 3 is operatively associated with the first component 2 through a threaded coupling (or other type, such as a bayonet, snap-fit, etc.) of the end 2c of the first component 2 with the internally threaded end 3b of the second component 3 if desired. As regards the closing cap 18, it may comprise or delimit 3 or at least one through conduit 18b, in use, in fluid communication with the first zone 1970369 of 45 of housing HA1. If desired, the closing cap 18 can be arranged to be placed in fluid communication with means for suctioning the air present inside the first housing area HA1. The closing cap 18 can be operationally associated with the end 2c of the first body 2a, for example before mixing the at least two compounds C1, C2, after having disassociated or unscrewed the second component 3. In particular, if the first body 2a has a threaded end 2c, the closing cap 18 will also have a threaded end 18a, so as to allow for easy connection between them. The suction means are capable of generating a pressure reduction within the first housing zone HA1 and can be activated, for example during the mixing of the at least two compounds C1, C2, in order to reduce the bubble formation of the mixture M and increase its properties. The suction means may include, for example, devices driven by a motor, preferably electric or based on the Venturi effect. Alternatively, the mixing device 1 may be placed in fluid communication with a centralized vacuum line provided, for example, in operating rooms. Of course, suction devices may not even be used or foreseen. Furthermore, the mixing device 1 may advantageously also comprise sealing means 19, for example one or more gaskets 19, possibly positioned in a respective annular seat 14c of the thrust component 14 and / or positioned in the through channel TC of the thrust component 14, intended to guarantee the fluid seal of the first housing area HA1 in correspondence with the thrust component 14. According to the non-limiting embodiment of the present invention shown in the figures, a first gasket 19a is provided in the through channel TC so that the fluid seal is guaranteed when the stem 12 is moved or, more specifically, made to slide inside the through channel TC for mixing the at least two compounds C1, C2, and a second gasket 19b is positioned in a respective annular seat 14c delimited by the thrust component 14 so that it is 1970369 de 45 guaranteed the fluid seal also at the edges 14d of the thrust component 14 of one of its faces, in use, internal IF to the first housing area HA1. A brief, non-limiting example of the operation of the present invention is described below. Let's assume that the entire process of obtaining the M mixture is performed by a single operator, such as a surgeon preparing a prosthesis or a joint spacer. Clearly, in this case, the M mixture will preferably be bone cement for medical use. Initially, the first component 2 is advantageously closed by the closing cap 18, if provided, to prevent environmental dust or foreign bodies from entering and polluting the first compound C1 present in the first housing area HA1. The operator can then remove the closing cap 18, for example by unscrewing it, and operationally associate, for example by screwing, the second component 3 with the first component 2. The mixing device 1 is thus in the rest operating configuration RC. The operator can then move or tilt the containment element 4 transversely or orthogonally to the axis or direction of transfer AD between a first rest position (see figure 1) in which a respective abutment portion is not in contact with or pushes against the second component 3 or with elements of the device integral with it and at least a second position (see figure 14) of breakage or opening in which the abutment portion impacts against the second component 3 or presses against it or with an element of the device integral with it to a greater extent than in the first position. This can be achieved, for example, by grasping the second body 3a, for example with a hand at the connecting end 3b of the second component 3 or the end 2c of the first component 2, and bending it or moving it at a respective portion or section 3c, 3d, 3f. The particular configuration of the second body 3 a, with any bending means 5 or, more specifically, with any weakening elements or portions 1970369 de 45 or, in even more detail, with the depressions 6 and the stiffening elements or sections 7, allow the bending of this second body 3a, for example in correspondence with these depressions 6. In doing so, the abutment portion 4b or, more specifically, the tip 4b of the containment elements 4 abuts a component or element or portion of the second component 3, such as a section of the internal wall of the section 3e and the pressure generated by this abutment causes the breakage of the containment elements 4 or, more specifically, of the vials 4 in correspondence with or in the vicinity of the breaking zone or point BZ delimited, for example, by the constriction 4c, if provided. The mixing device 1 is therefore in the bending operating configuration FC. In this FC bending operating configuration the second compound C2 is slowly released from the containment elements 4 since air can enter inside them, however, as can be understood, it may be uncomfortable for the operator to remain with the second body 3a bent in order to release all of the second compound C2. In this regard, the operator can, if the second body 3 is made of elastic or plastic material, release the bending or displacement or inclination of the latter so that the mixing device 1 passes into the REC release operating configuration. In this REC release operating configuration, it is possible to exploit the pumping means 8, if provided, or, more specifically, the one or more enlarged or balloon-shaped portions 8a delimited in the second body 3a to release more quickly or in any case facilitate the transfer of the second compound C2 from the second housing area HA2 to the first housing area HA1. In particular, the operator can press and subsequently release, if desired consecutively, the one or more enlarged or balloon-shaped portions 8a so as to decrease the air pressure inside the second housing area HA2 which thus allows the air pressure contained in the containment element 4 and the hydrostatic pressure of the second compound 2 to overcome the pressure acting, in use, on the breaking area or point BZ, in fact, releasing the second compound more quickly. 1970369 of 45 compound C2 in the second housing area HA2. The second compound C2, through the through-opening TO delimited in the connecting end 3b, can thus flow from the second housing region HA2 to the first housing region HA1. The broken parts, i.e. the contact portions 4b of the containment elements 4, are instead retained in the second housing region HA2, if desired by means of the retaining elements 3h positioned in correspondence with the through-opening TO. At this point the operator can disassociate, for example by unscrewing, the second component 3 from the first component 2 and reapply the closing cap 18, 10 if desired by operationally connecting it through the through-duct TD to the suction means, for example to create a vacuum inside the first housing area HA1, and then proceed with mixing the two compounds C1, C2 by means of the mixing means 10. Alternatively, in the event that the operator does not wish to create a vacuum, he can proceed to mix the two compounds C1, C2 using the mixing means 10 while keeping the second component 3 operationally associated with the first component 2. In particular, to mix the two compounds C1, C2 present in the first housing area HA1, the operator can grasp the handle component 11 to slide the stem 12 and therefore also the mixing component 13, connected or in any case supported by the second end 12b of the stem 12 itself, into the through channel TC of the thrust component 14. The mixing component 13 can then translate and / or rotate in the first housing area HA1, in fact, mixing the two compounds C1, C2 so as to obtain a mixture M. Before and during mixing, the mixing means 10 are in the mixing operating position MP while the thrust component 14 and the locking means 15 are in the rest operating position RD. Once the mixing of the two compounds C1, C2 is finished, the operator can, in the case in which he has carried out this mixing with the second component 3 still 3 0 operationally associated with the first component 2, disassociate this second component 29 1970369 de 45 and apply the closing cap 18 at the end 2c of the first component 2, for example by screwing. Subsequently, according to a possible but not necessarily present variant, the operator can grasp the handle component 11 to extract the stem 12 from the 5th through channel TC, for example by bringing it to the end of its travel and then rotating it, if desired in an anticlockwise direction, so as to release the end 12b of the stem 12 from the mixing component 13, which remains engaged, for example to a certain extent in the through channel TC, causing the mixing means 10 to pass from the mixing operating position MP to the closing operating position CP. The operator can then remove the closing cap 18 again and connect to the end 2c of the first component 2 some means of expulsion 20 of the previously obtained mixture M, for example a special cannula 20, visible according to a non-limiting embodiment in figure 13. Subsequently, the operator can remove the locking means 15 or, more specifically, the locking body 16, if desired having a substantially C-shaped plan configuration, so that the thrust component 14 passes from the rest operating configuration RD to the thrust operating configuration TD. Finally, the operator can mount or otherwise connect to the base body 14a of the pushing component 14 extrusion means, for example a pneumatic gun, 2 0 intended to push the pushing component 14 which in turn, being in the pushing operating position TD, can slide within the first housing area HA1 to extrude or expel the mixture M, for example into the expulsion means or in any case outside the first housing area HA1. Of course, in case a pneumatic gun is used, it will be advantageously compatible to be connected with the base body 14a of the push component 14. Referring now to figures 21 and 22, a device similar to the one described above is illustrated, but the second body 3 is in two pieces, a first tubular external piece 21 either incorporating or defining the constraint end 3b with a second end 3 or 3m opposite the constraint end 3b, which is open. In the second end 3m and then 1970369 de 45 mounted in a rotatable manner a second piece 22 of the body 3 a, which could advantageously also have a handle or grip 23 incorporated in a single piece. The containment elements 4 would in this case be mounted on the second piece 22, so that they would be mounted in a rotatable manner, if desired by means of the handle 23 with respect to the first piece 21. In this case, the device 1 could also comprise, internally to the second piece 22, if desired in a single piece or integral with it, one or more wall or blade portions 24 designed to intercept and break the containment elements 4, for example in correspondence with the breaking zone or point or opening BZ, when the latter are rotated together with a respective second piece 22. With such a device, to break or open the containment elements 4, one would have to, by means of a special handle 23, determine the rotation of the second rotating piece 22 and therefore of the containment elements 4, thus causing the latter to hit, if desired, the respective tip with a respective portion of the wall or knife 24, thus opening the containment elements 4. In this case, the expression transversely or orthogonally movable or tiltable must be interpreted in this case in the sense that the containment element 4 is movable by rotation around the axis or direction of transfer between the first rest position and the second breaking or opening position. In accordance with another variant illustrated in figure 23, the containment elements 4 are mounted in a sliding (and not rotatable) manner by means of a respective slide and shoe engagement with the second component 3. In this regard, the second end 3m of the second component 3 opposite the constraint end 3b defines at least one seat or groove in which the containment elements 4 or a respective support 25 are slidably mounted. The object of the present invention is also a method of mixing at least two compounds C1, C2 to obtain a mixture M. This method initially comprises the step of placing at least a first compound C1, for example a powder, such as one or more polymers, possibly acrylic, in a first housing area HA1 delimited by a first component 2 comprising 1970369 de 45 a first body 2a. Subsequently, the step of inserting at least one containment element 4, for example at least one vial, containing at least a second compound C2, if desired a liquid, such as a monomer, into a second housing area 5 HA2 delimited by a second component 3 comprising a second body 3 a is envisaged. The method according to the present invention then provides for the step of operationally associating the second component 3 with the first component 2, for example by screwing or bayoneting or a similar means. Clearly, the two components 2 and 3 can also be associated before positioning the at least one containment element 4. The phase of moving or tilting the containment element 4 transversely or orthogonally to the axis or direction of transfer between a first rest position and at least one second position is then foreseen. This can for example be obtained by bending the second body 3 a, if desired in correspondence with bending means 5, for example at least one element or at least one weakening portion 6, of the second body 3 a, so as to determine the displacement or bending also of the at least one containment element 4 integral in displacement with the body 3 a and therefore the breakage of the at least one containment element 4 following impact against a portion of the body 3a or of the device, thus releasing the at least one 0 second compound C2 so that the latter passes or flows from the second housing region HA2 to the first housing region HA1. Preferably, the method provides, following the phase described above, the phase of consecutively pressing and releasing the second body 3a, if desired in correspondence with the pumping section 3f so as to speed up the release of at least one second. 5 composed C2 of at least one containment element 4. The method according to the present invention then provides for the step of mixing in the first housing area HA1 the at least one first compound C1 with the at least one second compound C2 so as to obtain a mixture M. Subsequently, the step of disassociating the second component 3 from the first component 2 can be foreseen before or after the above mentioned mixing step, for example by 1970369 of 45 unscrewing. In the event that the disassociation phase is planned before the mixing phase, following this disassociation phase, the phase of aspirating, by means of suction means, the air present inside the first housing area HA1 can advantageously be planned so as to create a vacuum in it, for example in order to reduce the bubble content of the mixture M and increase its properties. Finally, the step of extruding or pushing the previously obtained mixture M out of the first housing area HA1 is foreseen, for example by means of extrusion, such as a pneumatic gun. This extrusion phase may include the sub-phase of operationally connecting the extrusion means to the first component 2. Furthermore, the extruding step may also comprise the sub-step of operatively connecting to the first component 2 means of expulsion 20 of the previously obtained mixture M, for example a cannula 20, so as to facilitate its expulsion. The method according to the present invention can be advantageously realized or carried out by means of a mixing device 1 according to the present invention or even more advantageously by means of a mixing device 1 according to the non-limiting embodiment shown in the figures. In particular, if made or performed by means of a mixing device 1 according to the non-limiting embodiment shown in the figures, the pressing and releasing step is preferably performed by means of the pumping means 8 or, more specifically, by means of the one or more swollen or raised portions 8a delimited in the second body 3a. Furthermore, if performed by means of a mixing device 1 according to the non-limiting embodiment shown in the figures, the mixing step is preferably performed by means of the mixing means 10, for example by grasping the handle component 11 to slide, inside the through channel TC delimited by the push component 14, the stem 12 and consequently also the mixing component 13 which can then translate and / or rotate in the first mixing zone. 1970369 of 45 housing HA1, in fact, mixing the two compounds C1, C2 so as to obtain a mixture M. Following the mixing phase, it may also be advantageously envisaged to extract the stem 12 of the mixing means 10 from the through channel TC, if desired up to the end of its travel, and subsequently rotate the handle component 11, for example in an anti-clockwise direction, so as to release the stem 12 or, more specifically, the end 12b thereof, from the mixing component 13 removably engaged with it. Furthermore, always considering that the method is carried out by means of a mixing device 1 according to the non-limiting embodiment shown in the figures, before the extruding phase, the phase of extracting or removing the locking means 15 or, more specifically, the locking body 16a is preferably foreseen, for example to be able to easily associate the extrusion means with the pushing component 14. As can be understood, the mixing device 1 as well as the method according to the present invention are easy and intuitive to use. Furthermore, compared to mixing devices taught by the state of the art, the mixing device 1 according to the present invention has fewer components and therefore lower costs, as well as a significantly lower structural complexity. Furthermore, the mixing device 1 according to the present invention allows for rapid and effective mixing of the compounds. Furthermore, the breaking of the at least one containment element 4 for the release of the at least one second compound C2 occurs by a clean cut or in any case not as foreseen according to the state of the prior art, preferably avoiding the fragmentation of the containment element 4 and, consequently, also the accidental fall of fragments inside the first housing area HA1 where the mixing of the at least two compounds C1, C2 will take place. It should be noted that the transfer of at least one second compound C2 and also its subsequent mixing with the at least one first compound C1 always takes place in a closed environment, and therefore safe from any external agents that could 1970369 de 45 comprometiere the use of the M mixture. It should also be considered that the mixing device 1 according to the present invention is very versatile, being able to be operationally associated, without further need for adaptation components, with extrusion and / or expulsion means to facilitate the exit of the mixture M from the first housing area HA1. It has thus been seen how the present invention fully achieves the proposed aims. The mixing device 1 as well as the method described above are susceptible to numerous modifications and variations within the scope of protection of the 10 claims that follow. Furthermore, all details are replaceable with other technically equivalent elements. In practice, the shapes and contingent dimensions may be any according to the needs without thereby departing from the scope of protection of the following claims. 1970369 of 45 CLAIMS 1. Mixing device (1) of at least two compounds (C1, C2) to obtain a mixture (M), comprising: - a first component (2) including a first body (2a) defining a first housing area (HA1) for at least one first compound (C1); - a second component (3), in use, operationally associable with said first component (2) so as to place said first and said second component (2, 3) in fluid communication defining a fluid transfer axis (AD) from said first (2) to said second (3) component, said second component (3) including a second body (3 a) defining a second housing area (HA2); - at least one containment element (4) of at least one second compound (C2), positioned or positionable within said second housing zone (HA2), said at least one containment element (4) comprising or delimiting at least one breaking or opening zone or point (BZ); said at least one containment element (4) being movable or tiltable transversely or orthogonally to said transfer axis (AD) between a first rest position in which a respective abutment portion (4b) is not in contact with or pushed such as to cause it to break or open against said second component (3) or with elements of said device integral with it and at least a second breaking or opening position in which said abutment portion (4b) impacts against said second component (3) or presses against it or with an element of said device integral with it to a greater extent than in said first position,so that in the transition from said first to said at least one second position said at least one containment element (4) breaks or opens such that the at least one second compound (C2) therein passes or flows from said second housing region (HA2) to said first housing region (HA1) along said fluid transfer axis (AD)., 2. Device according to claim 1, wherein said second component (3) has a constraint or connection end (3b) to said first component (2) defining or developing around said fluid transfer axis (AD) and at least one protruding section (3c, 3d, 3f) from said constraint or connection end (3b) and 1970369 de 45 tiltable or bendable with respect to said fluid transfer axis (AD), said at least one containment element (4) being integral in displacement or inclination with said at least one projecting section (3c, 3d, 3f), so that by determining the inclination or bending of said at least one projecting section (3c, 3d, 3f) with respect to said constraint or connection end (3b) the inclination of said at least one containment element (4) mounted within said second component (3) is caused and therefore the passage of the same between said first and said at least one second position and the respective breaking or opening of the same. 3. Device according to claim 1 or 2, characterized in that said second component (3) comprises folding means (5) configured to allow or facilitate the folding of at least one portion or section (3c, 3d, 3f) of said second body (3a) from said first to said at least one second position, so as to cause the breaking or opening of said at least one containment element (4) at or in the vicinity of said breaking or opening zone or point (BZ) so that the at least one second compound (C2), in use, passes or flows from said second housing zone (HA2) to said first housing zone (HA1). 4. Mixing device (1) according to the preceding claim, wherein said bending means (5) are or comprise at least one weakening element or portion (6) delimited in said second body (3a) so that, following the bending of the latter, it bends in correspondence with said at least one weakening element or portion (6) to cause the breaking or opening of said at least one containment element (4) in correspondence with or in the vicinity of said breaking or opening zone or point (BZ). 5. Mixing device (1) according to any of the preceding claims, wherein said second component (3) comprises or delimits one or more stiffening elements or sections (7) configured to stiffen said second body (3 a) so that the latter, in use, does not bend at said one or more stiffening elements or sections (7). 6. Mixing device (1) according to any of the preceding claims, wherein said second component (3) comprises pumping means (8) 1970369 of 45 configured, in use, to expedite the release or facilitate the transfer of the at least one second compound (C2) from said at least one containment element (4) to said second housing area (HA2) once said at least one containment element (4) has been broken or opened. 7. Mixing device (1) according to the preceding claim, wherein said pumping means (8) are or comprise one or more enlarged or balloon-shaped portions (8a) delimited in said second body (3a). 8. Mixing device (1) according to claim 6 or 7, wherein said pumping means are defined by a pumping section (3f) of said second component (3), said pumping section (3f) comprising at least two main sections (3f1, 3f2) opposed at a distance from each other greater than the width of said at least one containment element (4), so that a pumping area (PA) is present between said at least one containment element (4) and at least one of the two main sections (3f1, 3f2) once said at least one containment element (4) is housed in the second housing area (HA2), said pumping section (3f) also presenting one or two lateral sections (3f3, 3f4) connecting the two main sections (3f1, 3f2) and which are at a distance from each other equal to the width of said at least one containment element (4), so that said at least one containment element (4), in the pumping section (3f) is,in a condition at rest or not pumping the latter, not in contact with at least one main segment (3f1, 3f2) and in contact or in any case close to said two lateral segments (3f3, 3f4). 9. Mixing device (1) according to any of the preceding claims, wherein said second component (3) has, from one end to the other, several tubular sections, one with a different section from the others, designed to internally define a specific face or internal surface defining the second housing area (HA2), said sections comprising at least one section (3 c, 3d) for retaining said at least one containment element (4) designed to tighten or enclose a respective part of said at least one containment element (4) so ​​as to maintain it in a specific relative position with respect to said second component or to a connection end (3b) thereof and at least one reception section (3e) with slack or play 1970369 of 45 of a respective abutment portion (4b) of said at least one containment element (4). 10. Mixing device according to claim 9, wherein said at least one retaining section (3c, 3d) is defined internally by respective projections or protuberances or recesses (3c1, 3d1) designed to engage a respective portion of said at least one containment element (4). 11. Mixing device according to claim 9 or 10, wherein said reception section (3e) has an internal cross-section larger than a respective portion (4b) of said at least one containment element (4) or in any case the portion (4b) of said at least one containment element (4) arranged within the area or zone defined by said at least one reception section (3e) is not clamped by the latter and is free to move or tilt with respect to said at least one reception section (3e) in the passage from the first to the second position. 12. Mixing device (1) according to any of the preceding claims, wherein said second component (3) comprises or delimits at least one positioning seat (PS) configured to support said at least one containment element (4). 13. Mixing device (1) according to the previous claim, wherein said at least one containment element (4) is engaged in said at least one positioning seat (PS) by forced or measured coupling. 14. Mixing device (1) according to any of the preceding claims, wherein said second component (3) comprises or delimits a connecting end (3b) to said first component (2), said connecting end (3b) defining at least one through opening (TO) so as to permit, in use, the passage or transfer of said at least one second compound (C2) from said second housing region (HA2) to said first housing region (HA1). 15. Mixing device (1) according to any of the preceding claims when dependent on claim 3, wherein said second component (3) operatively associated, in use, with said first component (2) comprises at least three operational configurations (RC, FC, REC), said at least three operational configurations 1970369 de 45 (RC, FC, REC) comprising at least one rest operating configuration (RC) in which said second body (3 a) is not bent and said at least one containment element (4) is not broken or opened, at least one bending operating configuration (FC) in which said second body (3a) is bent at said bending means (5) and said at least one containment element (4) abuts with said second body (3a) thereby causing the breakage or opening of said at least one containment element (4) at or in the vicinity of said breakage or opening zone or point (BZ),and at least one release operational configuration (REC) wherein said second body (3a) is not bent or folded less than said bend operational configuration and said at least one containment element (4) is broken or opened at or in the vicinity of said break or opening zone or point (BZ) so as to permit the release of said at least one second compound (C2) into said second housing zone (HA2)., 16. Mixing device (1) according to claim 2 and according to the preceding claim, wherein, in said bending operating configuration (FC), the bending of said second body (3a) in correspondence with said bending means (5) brings said abutment portion (4b) into contact with said second body (3a) and the pressure generated by said abutment causes the breaking or opening of said at least one containment element (4) in correspondence with or in the vicinity of said breaking or opening zone or point (BZ). 17. Mixing device (1) according to any of the preceding claims, wherein said first component (2) comprises mixing means (10) configured, in use, to mix said at least one first compound (C1) with said at least one second compound (C2). 18. Mixing device (1) according to the preceding claim, wherein said mixing means (10) comprise at least one handle component (11), a stem (12) including a first end (12a) connected to said handle component (11) and a second end (12b), and a mixing component (13), connected to or supported by said second end (12b) of said stem (12), intended, in use, to be translated and / or rotated within said first housing region (HA1) for mixing the at least two compounds (C1, C2). 1970369 of 45 19. A mixing device (1) according to any preceding claim, wherein said first component (2) comprises at least one push component or piston (14), slidably mounted in said first housing region (HA1), and configured, in use, to push or press the mixture (M) out of said first housing region (HA1), and means (15) for locking said push component (14) at an end of the first component (2) distal, in use, from the second component (3). 20. Mixing device (1) according to the preceding claim, wherein said locking means (15) define with said at least one thrust component (14) at least two operating settings (RD, TD), said at least two operating settings (RD, TD) comprising at least one rest or locking operating setting (RD) wherein said locking means (15) are operatively associated with said thrust component (14) for locking the latter which is not able to slide in said first housing area (HA1) and at least one release or thrust operating setting (TD) wherein said locking means (15) are not operatively associated with said thrust component (14) which, in use, is able to slide and be pushed in said first housing area (HA1). 21. Mixing device (1) according to claim 20, wherein the movement or passage between said at least one rest or locking operating position (RD) and said at least one release or thrust operating position (TD) is obtainable by relatively moving said first component (2) and said locking means (15) in a transverse or orthogonal direction to the longitudinal development axis xx of said first component (2). 22. A mixing device (1) according to claim 19 or 20 or 21, wherein said locking means (15) is or comprises a locking body (16) including at least one engaging or housing component or portion (16a) and wherein said at least one pushing component (14) comprises a base body (14a) including at least one groove or lug (14b) intended to house said engaging component or portion (16a) or be engaged in said housing component or portion (16a). 1970369 of 45 23. Mixing device (1) according to the preceding claim, wherein said component or engaging portion (16a) has a substantially C- or U-shaped plan configuration and is removably engaged in said at least one groove (14b) of said thrust component (14). 24. Mixing device (1) according to claim 18 or 19 or 20 or 21 or 22, wherein said first body (2a) comprises a flanged or enlarged end (2b) opposite the respective connecting end (2c) to said second component (3), said locking means (15) comprising a first main wall section (16b) and a side wall (16c) connecting said first main wall section (16b) to said component or engagement or housing portion (16a) and defining therewith a coupling zone (IZ) for said enlarged end (2b). 25. Mixing device (1) according to any of the preceding claims, wherein said first body (2a) is laterally tubular and has a connecting end (2c) to the second component (3), said first body (2a) having both its ends (2b, 2c) open, or even with only one open end, which is the connecting end (2c) to the second component (3). 26. Mixing device (1) according to claim 25, wherein an end (3b) of said second component (3) is operatively associated with the connecting end (2c) of said first body (2a) through threaded coupling, bayonet engagement or push-fit or other type of engagement. 27. Method of mixing at least two compounds (C1, C2) to obtain a mixture (M), comprising the steps of: - placing at least a first compound (C1) in a first housing area (HA1) delimited by a first component (2) comprising a first body (2a); - insert at least one containment element (4) containing at least a second compound (C2) into a second housing area (HA2) delimited by a second component (3) comprising a second body (3 a). - operationally associate said second component (3) with said first component (2); - move or tilt said at least one containment element (4) 1970369 of 45 transversally or orthogonally to the transfer axis (AD) between a first rest position in which a respective abutment portion (4b) is not in contact with or pushed so as to cause the breakage or opening against said at least one second component (3) or with elements of the device integral with it and at least one second breakage or opening position in which the abutment portion (4b) impacts against said at least one second component (3) or presses against it or with an element of the device integral with it to a greater extent than in the first position, so as to cause the breakage or opening of said at least one containment element (4) to release said at least one second compound (C2) so that the latter passes or flows from said second housing area (HA2) to said first housing area (HA1) along said fluid transfer axis (AD); - mixing in said first housing area (HA1) said at least one first compound (Cl) with said at least one second compound (C2) so as to obtain a mixture (M); - extrude or push out of said first housing area (HA1) said previously obtained mixture (M). 28. Method according to claim 27, wherein said displacement or inclination step is obtained by bending a respective portion or section (3c, 3d, 3f) of said second body (3a) of said second component (3) integral in displacement or inclination with said at least one containment element (4). 29. Method according to the preceding claim, carried out by means of a mixing device (1) according to any of claims 1 to 26. Buenos Aires, September 2022 pp TECRES SpA 1970369 of 45 SUMMARY The present invention relates to a mixing device for at least two compounds, such as a liquid and a powder, to obtain bone cement, as well as a method for mixing at least two compounds using such a mixing device. 1970369 of 45 RICARDO DANIEL RICHELET - 20042804046 Digitally signed by PORTALTRAMITES - INPI Dates: 2022.09.27 11:58:57 -03:00 Reason: Digitally signed by the INPI Location: Buenos Aires, Argentina 1970369

Claims

1. A mixing device (1) for at least two compounds (C1, C2) to obtain a mixture (M), comprising: - a first component (2) including a first body (2a) defining a first housing zone (HA1) for at least one first compound (C1); - a second component (3), in use, operatively associateable with said first component (2) to put said first and said second components (2, 3) into fluid communication by defining a fluid transfer axis (AD) from said first component (2) to said second component (3), said second component (3) including a second body (3a) defining a second housing zone (HA2); - at least one containment element (4) for at least one second compound (C2), positioned or positionable within said second housing zone (HA2), said at least one containment element (4) comprising or delimiting at least one rupture or opening zone or point (BZ),said at least one containment element (4) being movable or tiltable transversely or orthogonally to said transfer axis (AD) between a first rest position in which a respective intersecting part (4b) is not in contact with or pushes so as to cause breakage or opening against said second component (3) or with elements of said device integrated therein and at least a second breakage or opening position in which said intersecting part (4b) impacts against said second component (3) or presses against it or with an element of said device integrated therein to a greater extent with respect to said first position,so that in the passage from said first to said at least one second position, said at least one containment element (4) breaks or opens so that the at least one second compound (C2) inside passes or flows from said second housing zone (HA2) to said first housing zone (HA1) along said fluid transfer axis (AD), characterized in that said second component (3) comprises pumping means (8) configured, in use, to accelerate the release or facilitate the transfer of the at least one second compound (C2) from said at least one containment element (4) to said second housing zone (HA2) once said at least one containment element (4) has broken or opened, said pumping means (8) is or comprises one or more elongated or globe-shaped parts (8a) delimited in said second body (3a),and / or said second body (3a) is made of thermoplastic polyurethane or TPU and said second component (3) is totally or partially translucent or transparent. 26 Claims follow,