A METHOD FOR THE PREPARATION OF 1-(4-(5-(HALOMETHYL)-1,2,4-OXADIAZOL-3-YL)PHENYL)ETHA-1-ONE

AR135140A1Pending Publication Date: 2026-07-08PI IND LTD

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Patent Information

Application Number: ARP20240103648
Authority / Receiving Office: AR · AR
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2024-01-03
Filing Date: 2024-12-27
Publication Date: 2026-07-08

Application Information

Patent Timeline

03 Jan 2024

Priority

27 Dec 2024

Application

ARP20240103648

08 Jul 2026

Publication

AR135140A1

IPC: C07D271/02; C07D271/06; A61K31/4245

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Claims

The present invention relates to a method for preparing a compound of formula (1) and its intermediate compounds of formula (2) and formula (3), wherein R1, R2, L, R4, R5, and n are as defined in the description. The present method comprises a step of converting a dioxime compound of formula (5) into a compound of formula (3) in a single step through simultaneous cyclization and deprotection of ketoxime to obtain the compound of formula (3), which was then subjected to further halogenation and reaction with a compound of formula (9) to obtain the compound of formula (1).