ANTI-APRIL ANTIBODIES
Patent Information
- Application Number
- ARP20250100918
- Authority / Receiving Office
- AR · AR
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-04-09
- Filing Date
- 2025-04-07
- Publication Date
- 2026-10-14
Claims
Antibodies that bind specifically to APRIL are described, as well as methods for preparing and using such antibodies.
1. An antibody that binds to a proliferation-inducing ligand (APRIL), or an antigen-binding fragment thereof, comprising: (a) a variable heavy chain (VH) domain comprising an amino acid sequence selected from any of SEQ ID Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 and 61; and (b) a variable light chain (VL) domain comprising an amino acid sequence selected from any of SEQ ID Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60 and 62.
2. An antibody that binds to APRIL, or an antigen-binding fragment thereof, comprising: (a) a variable heavy chain (VH) domain comprising an amino acid sequence that is at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to a portion of the amino acid sequence of any of the SEQ ID Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 and 61; and (b) a variable light chain (VL) domain comprising an amino acid sequence that is at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to a portion of the amino acid sequence of any of SEQ ID Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60 and 62.
12. A nucleic acid sequence encoding the antibody or antigen-binding fragment thereof of any of claims 1-11.
13. A vector comprising the nucleic acid sequence of claim 12.
14. A host cell comprising the nucleic acid sequence of claim 12 or the vector of claim 13.