MACROCYCLIC HETEROCYCLES AND THEIR USES

Claims

This description provides pharmaceutically acceptable compounds and salts thereof, and methods of use thereof. The compounds and methods have a variety of applications as therapeutic, diagnostic, and research tools. In particular, the present compositions and methods are useful for reducing the production of oncogenic protein signaling. A compound of formula (1). A pharmaceutical composition comprising a compound of any one of the preceding claims, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient.