COSMETIC PREPARATION AGAINST ACNE

Abstract

The invention relates to a cosmetic product which consists of a package having two spatially separate chambers, the first containing a lyophilisate of bacteria of the strains C. acnes 6609 (H1), C1, C3, D1, A5, H1, H2, H3, K1, K2, K4, K6,K8, K9, L1 and / or F4, and the second chamber containing a water-containing cosmetic preparation. The invention also relates to a method for treating acne with this preparation.

Description

[0001] Cosmetic preparation against acne

[0002] The present invention relates to a cosmetic product comprising a packaging medium with two spatially separated chambers, wherein the first chamber contains a lyophyllisate of bacteria of the strains C. acnes 6609 (H1), C1, C3, D1, A5, H1, H2, H3, K1, K2, K4, K6, K8, K9, L1 and / or F4, and the second chamber contains a water-containing cosmetic

[0003] The preparation contains a method for treating acne with this preparation.

[0004] The desire to look beautiful and attractive is rooted in human nature. Even though the ideal of beauty has changed over time, the pursuit of a flawless appearance has always been a human goal, as a pleasing appearance boosts self-esteem and attractiveness to others. The condition and appearance of the skin plays a significant role in achieving a beautiful and attractive appearance.

[0005] In oily and impure skin, which is considered the transitional state between healthy, normal skin and pathologically altered acne-prone skin, the skin produces increased amounts of sebum (seborrhea). This serves as an ideal breeding ground for numerous microorganisms, especially Propionibacterium acnes (nowadays referred to as Cutibacterium acnes, C. acnes, which is why the new abbreviation C. acnes is used instead of P. acnes in this disclosure) and Pityrosporum species.

[0006] Microorganisms decompose sebum into glycerol and fatty acids, stimulating the sebaceous glands to increased production and attacking and destroying the follicle walls in the skin. This causes inflammation in the skin (pimples, pustules, nodules, cysts), which often heal only with scarring, thus permanently damaging the appearance of people suffering from impure skin (W. Umbach [ed.], Cosmetics, Development, Production and Application of Cosmetic Products, 2nd ed. Thieme Verlag, Stuttgart, 1995).

[0007] Acne (in the narrower sense, acne vulgaris) refers to various diseases of the sebaceous gland follicles, which are caused by secretion and keratinization disorders, resulting in the following

[0008] Acne vulgaris is characterized by inflammation and possible scarring. It occurs mainly during puberty and is usually concentrated on areas of skin rich in sebaceous glands (face, neck, chest, back). Sebaceous gland hyperplasia and a keratinization disorder of the follicles lead to blockage, resulting in the formation of comedones and the characteristic lesions of acne vulgaris (Pschyrembel, Clinical Dictionary, 258th edition, Walter de Gruyter Publishing House, Berlin, 1998).

[0009] Conventional products for treating oily and / or impure skin, as well as acne-prone skin, usually have the disadvantage of stressing and drying out the skin and providing little nourishment.

[0010] Furthermore, highly acidic (pH values ​​below pH 4.0) and strongly oxidizing agents (e.g., benzoyl peroxide) are used in the treatment of acne, which

[0011] Stress the skin's acid mantle and attack or burn the skin.

[0012] It was therefore an object of the present invention to develop a significantly milder and more nourishing cosmetic and / or dermatological preparation for the treatment of oily and impure skin, as well as for the treatment of acne (and in particular acne vulgaris), than those known from the prior art. Furthermore, it was an object of the present invention to develop a cosmetic and / or dermatological preparation for the treatment of acne (and in particular acne vulgaris) that is effective at a skin-friendly pH (pH greater than 4.0), does not corrode the skin, and places only a minimal burden on the skin's acid mantle. Preparations were also to be developed that, at a skin-friendly pH (pH greater than 4.0),

[0013] The growth and spread of acne-causing bacteria on the skin

[0014] suppress. Furthermore, these preparations should significantly reduce the concentration of acne-causing bacteria on the skin and in the sebaceous glands.

[0015] The problems are surprisingly solved by a cosmetic product consisting of a packaging material with two spatially separated chambers, wherein the first chamber contains a lyophyllisate of bacteria of the strains C. acnes 6609 (H 1 ), C1 , C3, D1 , A5, H 1 , H2 , H3, K1 , K2, K4, K6, K8, K9, L1 and / or F4 and the second chamber contains water

[0016] Contains a cosmetic preparation.

[0017] The lyophyllisate can be obtained from bacteria of strains C. acnes 6609 (H1), C1, C3, D1, A5, H1, H2, H3, K1, K2, K4, K6, K8, K9, L1 and / or F4 according to one of the conventional methods.

[0018] Prior art methods for the lyophilization of bacteria (for example, with the addition of dextran and / or glycerin) can be prepared and are described in standard works on pharmaceutical technology. While the prior art includes WO 2016 / 172196 and WO 2018 / 073651, which also disclose the C. acnes strains according to the invention, these documents did not provide a path to the present invention because, among other things, they do not disclose the medium with which the C. acnes bacteria can be activated in sufficient quantities. Although WO 2016 / 172196 mentions the fundamental possibility of using

[0019] The use of freeze-dried bacteria was noted, but the expert found it extremely difficult to reactivate them on the skin in medically safe yet effective quantities within a short time. It is also not disclosed how the bacteria can be applied to the affected skin areas in a targeted and uniform (homogeneous) concentration in a way that is easy for laypersons to handle, as not every cosmetic product is a suitable carrier. Phase separations,

[0020] Agglomeration, separation from the preparation, and viscosity changes are typical problems that occur when incorporating lyophilisates. Furthermore, virtually all cosmetics contain ingredients intended to protect them from microbial degradation, so it could be assumed that in a simple combination of cosmetic preparation and bacteria, the latter would be more or less completely killed by the preservative components of the cosmetic preparation.

[0021] The first chamber may contain cosmetic materials in addition to the lyophyllisate from bacteria.

[0022] The product contains components such as oils and / or thickeners. It may also be advantageous, as proposed in WO 2018 / 073651, to add peptone and / or hydroxyethylcellulose according to the invention.

[0023] According to the invention, it is preferred to use the C. acnes strains C3 and / or K8.

[0024] According to the invention, the combination of both strains in equal proportions is particularly preferred.

[0025] According to the invention, it is particularly preferred to combine these strains (i.e. C3 and / or K8) with C. acnes strains A5 and / or F4.

[0026] According to the invention, it is advantageous if the cosmetic preparation in the second chamber has a pH value of 4 to 8.

[0027] To give the product according to the invention the correct consistency for its application, it is advantageous according to the invention if the cosmetic preparation in the second chamber contains one or more thickening agents. It is particularly advantageous within the meaning of the present invention if the cosmetic preparation in the second chamber has a viscosity of at least 500 mPas. According to the invention, the viscosities are measured using the Rheomat R 123 instrument with spindle measuring body 1 and a constant rotational speed of 62.5 rpm at a temperature of 25°C.

[0028] According to the invention, it is preferred if the cosmetic preparation in the second chamber contains carrageenan and / or polyacrylic acid. The term "carrageenan" encompasses...

[0029] According to the invention, polyacrylic acid also includes the salts (especially the sodium salt) of this compound.

[0030] If the preparation contains carrageenan, a concentration of 0.01 to 1% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0031] If the preparation contains polyacrylic acid (carbomer), a concentration of 0.01 to 1% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0032] However, according to the invention, thickening the preparation in the second chamber with xanthan gum is a disadvantage because in this case it leads to agglomerate formation and

[0033] Clumping can occur during preparation.

[0034] Therefore, advantageous embodiments of the present invention are characterized by the fact that

[0035] characterized as being free of xanthan gum in the second chamber.

[0036] It is advantageous according to the invention if the cosmetic preparation in the second chamber is free of parabens and methylisothiazolinone.

[0037] Chloromethylisothiazolinone, 3-iodo-2-propynylbutyl carbamate, DMDM ​​hydantoin, 2-hydroxy-4-methoxybenzophenone, 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isamyl ester, 3-(4-methylbenzylidene) camphor.

[0038] In general, according to the invention, it is preferred if the cosmetic preparation in the second chamber is free of antimicrobial substances. Therefore, according to the invention, the second chamber of the product is advantageously designed such that filling takes place under sterile conditions, the chamber is subsequently sealed airtight, and its contents are removed from the storage container by means of a dispensing device in a single application.

[0039] Mixing with the lyophyllisate from the first chamber is immediately applied.

[0040] Advantageous embodiments of the present invention are also characterized in that the cosmetic preparation in the second chamber contains glycerin, panthenol, ubiquinone Q10 and / or hyaluronic acid.

[0041] If the preparation contains glycerin, a concentration of 1 to 10% by weight, based on the total weight of the cosmetic preparation, is in the second chamber.

[0042] Preferred according to the invention.

[0043] If the preparation contains panthenol, a concentration of 0.01 to 5% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0044] If the preparation contains hyaluronic acid, a concentration of 0.01 to 2 wt%, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0045] If the preparation contains ubiquinone Q10, a concentration of 0.01 to 0.05 wt% based on the total weight of the cosmetic preparation in the second chamber is preferred according to the invention.

[0046] Furthermore, cosmetic preparation can be carried out in the second chamber.

[0047] According to the invention, preferably anti-inflammatory substances are contained, for example, polidocanol, bisabolol, aloe vera extract, chamomile flower extract, glycyrrhiza inflata root extract.

[0048] According to the invention, a water content of up to 100% by weight, based on the total weight of the cosmetic preparation in the second chamber, is advantageous for the cosmetic preparation in the second chamber. It is also advantageous according to the invention if the cosmetic preparation in the second chamber contains salicylic acid, lactic acid, and / or citric acid.

[0049] If the preparation contains salicylic acid, a concentration of 0.01 to 2% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0050] If the preparation contains lactic acid, a concentration of 0.01 to 3% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0051] If the preparation contains citric acid, a concentration of 0.01 to 2% by weight, based on the total weight of the cosmetic preparation in the second chamber, is preferred according to the invention.

[0052] According to the invention, the cosmetic preparation in the second chamber can advantageously contain one or more perfume substances. These perfume ingredients can be selected, for example, from the group of compounds including limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diesters, alpha-amylcinnamaldehyde, alpha-methyl ionone, amyl C, butylphenyl methylpropional cinnamal, amyl salicylate, amylcinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, and cinnamal.

[0053] Cinnamyl alcohol, citronellyl methyl crotonate, lemon oil, coumarin, diethyl succinate,

[0054] Ethyl linalool, Eugenol, Ethylene brassylate, Evernia furfuracea extract, Evernia prunastri extract, Farnesol, Guaiac wood oil, Geraniol, Hexyl cinnamal, Hexyl salicylate, Hydroxycitronellal, Lavender oil, Lemon oil, Linalyl acetate, Mandarin oil, Menthyl PCA, Methylheptenone, Nutmeg oil, Rosemary oil, Sweet orange oil, Terpineol, Thymol, Tonka bean oil

[0055] Triethyl citrate and / or vanillin.

[0056] According to the invention, the cosmetic preparation in the second chamber can preferably be in two forms:

[0057] The first form is characterized in that the cosmetic preparation in the second chamber is in the form of an aqueous preparation. In this embodiment, it is preferred according to the invention if the preparation is in the form of a gel. The second form is characterized in that the cosmetic preparation in the second chamber is in the form of an oil-in-water emulsion.

[0058] In this case, according to the invention, it is advantageous if the cosmetic preparation in the second chamber contains glyceryl stearate citrate, cetearyl alcohol, sodium cetearyl sulfate,

[0059] Glyceryl stearate, cetearyl sulfosuccinate, sodium stearoyl glutamate, polyglyceryl-3-methylglucose distearate, stearic acid, potassium cetyl phosphate, polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate) and / or polyclyceryl-2 caprate.

[0060] However, preparation methods based on W / O emulsions are disadvantageous according to the invention.

[0061] Advantageous embodiments of the present invention are also characterized in that the cosmetic preparation in the second chamber contains starch.

[0062] If the preparation according to the invention contains an oil phase (for example, if an O / W emulsion is used in the second chamber), it is advantageous according to the invention if the cosmetic preparation contains triglycerides and / or

[0063] Contains octyldodecanol.

[0064] In addition, the oil phase may contain oils from the group of lecithins, cocoglycerides, olive oil, sunflower oil, jojoba oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheat germ oil, grapeseed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.

[0065] However, it is disadvantageous if the cosmetic preparation in the second chamber contains silicone oils, mineral oil and polyethylene glycols.

[0066] Advantageous embodiments of the present invention are therefore characterized in that the cosmetic preparation in the second chamber is free of silicone oils, mineral oil, and polyethylene glycols. To ensure safe application from a medical perspective and effective application from a cosmetic perspective, a balanced ratio of lyophilisate to water-containing cosmetic preparation is important.

[0067] It is therefore advantageous according to the invention if the weight ratio of lyophilisate to water-containing cosmetic preparation is 1 :10 to 1 :100.

[0068] According to the invention, preferably the cosmetic product contains, after mixing the contents of both chambers, 1-10 wt% lyophilisate and 99-90 wt% water.

[0069] cosmetic preparation containing.

[0070] Furthermore, it is advantageous in the sense of the present invention if the ratio of lyophilisate to water-containing cosmetic preparation is selected such that 10 4 up to 10 7 Bacteria are found on 2g of water-containing cosmetic preparation.

[0071] Advantageous embodiments of the present invention are characterized in that the packaging means includes a dispensing device and a mixing device with which the contents of both chambers can be mixed in the closed system and the mixture can be removed from an opening.

[0072] It is also advantageous according to the invention if the volume of the second chamber is 1.5 to 2.5 cm³. 3 amounts.

[0073] Examples of packaging materials that can be used include Lyo-Ject® dual-chamber syringes, V-LK® dual-chamber cartridges, or dual-chamber systems, as used in the

[0074] WO2018077598 A1 are revealed.

[0075] According to the invention, a method for the cosmetic treatment of acne is also characterized in that the contents of the first and second chambers of a cosmetic product according to the invention, described above, are mixed and extracted in an amount of 0.003 to 0.005 g / cm². 2 It should be applied to skin affected by acne.

[0076] The application to the skin usually takes place 0-12 seconds after the contents of both chambers have been mixed together.

[0077] According to the invention, it is advantageous for the acne-affected skin to be cleansed with a surfactant-containing cleansing preparation before applying the cosmetic product. It is also advantageous according to the invention if the acne-affected skin is disinfected with a benzoyl peroxide-containing preparation before applying the cosmetic product.

[0078] Example

[0079] The following example is intended to illustrate the present invention without limiting it. Unless otherwise stated, all quantities, proportions, and percentages refer to the weight and total quantity or total weight of the preparations.

[0080] The following example formulations can be found in packaging such as Lyo-Ject® dual-chamber syringes or Multi-Chamber blisters (Rohrer AG). The examples from the first and second chambers are combined below.

[0081]

[0082] * The C. acnes strains mentioned in claim 1 are used individually or in combination in the specified quantity.

Claims

Patent claims 1. Cosmetic product consisting of a packaging material with two spatially separated chambers, wherein the first chamber contains a lyophyllisate of bacteria of strains P. acnes 6609 (H 1 ), C1 , C3, D1 , A5, H 1 , H2, H3, K1 , K2, K4, K6, K8, K9, L1 and / or F4 and the second chamber contains a water-containing cosmetic preparation.

2. Cosmetic product according to claim 1, characterized in that the The cosmetic preparation in the second chamber has a pH value of 4 to 8.

3. Cosmetic product according to any one of the preceding claims, wherein characterized by the fact that the cosmetic preparation is in the second chamber Contains carrageenan and / or polyacrylic acid.

4. Cosmetic product according to any of the preceding claims, wherein characterized as being free of xanthan gum in the second chamber.

5. Cosmetic product according to any of the preceding claims, wherein characterized that the cosmetic preparation in the second chamber is free of parabens, methylisothiazolinone, Chloromethylisothiazolinone, 3-iodo-2-propynylbutylcarbamate, DMDM ​​hydantoin, 2-hydroxy-4-methoxybenzophenone, 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isoamyl ester, 3-(4-methylbenzylidene) camphor.

6. Cosmetic product according to any of the preceding claims, wherein characterized that the cosmetic preparation contains glycerin, panthenol, ubiquinone Q10 and / or hyaluronic acid in the second chamber.

7. Cosmetic product according to any of the preceding claims, wherein characterized by the fact that the cosmetic preparation is in the second chamber Contains salicylic acid, lactic acid and / or citric acid.

8. Cosmetic product according to any one of the preceding claims, wherein characterized in that the cosmetic preparation in the second chamber is in the form of an aqueous preparation.

9. Cosmetic product according to any one of the preceding claims 1 to 7, characterized in that the cosmetic preparation in the second chamber is in the form of an oil-in-water emulsion.

10. Cosmetic product according to claim 9, characterized in that the cosmetic preparation in the second chamber glyceryl stearate citrate, Cetearyl alcohol, sodium cetearyl sulfate, glyceryl stearate, cetearyl sulfosuccinate, sodium stearoyl glutamate, polyglyceryl-3-methylglucose distearate, stearic acid, potassium cetyl phosphate, polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate) and / or polyclyceryl-2 caprate.

1. Cosmetic product according to one of the preceding claims 9 to 10, characterized in that the cosmetic preparation in the second chamber contains starch.

12. Cosmetic product according to one of the preceding claims 9 to 10, characterized in that the cosmetic preparation is contained in the second chamber Contains triglycerides and / or octyldodecanol.

13. Cosmetic product according to any of the preceding claims, wherein characterized by the fact that the cosmetic preparation contains one or more perfume substances in the second chamber.

14. Cosmetic product according to any of the preceding claims, wherein characterized that the cosmetic preparation in the second chamber is free of silicone oils, mineral oil and polyethylene glycols.

15. Cosmetic product according to any of the preceding claims, wherein characterized in that the cosmetic preparation in the second chamber has a viscosity of at least 500 mPas.

16. Cosmetic product according to any of the preceding claims, wherein characterized by the fact that the weight ratio of lyophilisate to water-containing cosmetic preparation is 1:10 to 1:

100.

17. Cosmetic product according to any of the preceding claims, wherein characterized in that the ratio of lyophilisate to water-containing cosmetic preparation is chosen such that 10 4 up to 10 7 Bacteria are found on 2g of water-containing cosmetic preparation.

18. Cosmetic product according to any of the preceding claims, wherein characterized by the fact that a lyophyllisate of bacteria of the strains C. acnes strains C3 and / or K8 is used in the first chamber.

19. Cosmetic product according to claim 18, characterized in that the C. acnes strains C3 and K8 are used in equal proportions.

20. Cosmetic product according to one of the preceding claims 18 and 19, characterized by the fact that the bacterial strains in the first chamber are combined with C. acnes strains A5 and / or F4.

21. Cosmetic product according to any of the preceding claims, wherein characterized in that the packaging material has a dispensing device and Includes a mixing device with which the contents of both chambers are combined. The mixture is mixed in a closed system and can be taken from an opening.

22. Cosmetic product according to any of the preceding claims, wherein characterized by the volume of the second chamber being 1.5 to 2.5 cm³ 3 amounts.

23. Method for the cosmetic treatment of acne, characterized in that the contents of the first and second chambers of a cosmetic product according to one of the preceding claims are mixed and extracted in an amount of 0.003 to 0.005 g / cm². 2 It should be applied to skin affected by acne.

24. Method according to claim 23, characterized in that the skin affected by acne is cleansed with a surfactant-containing cleansing preparation before the application of the cosmetic product.

25. Method according to one of claims 23 or 24, characterized in that the skin affected by acne is disinfected with a benzoyl peroxide-containing preparation before the application of the cosmetic product.