Crbn e3 ligase ligand compound, protein degrading agent developed on the basis of ligand compound, and their applications

Abstract

The present disclosure relates to compounds of formula (I), formula (II) and formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs or polymorphs thereof, and applications thereof. The present disclosure also relates to a pharmaceutical composition containing the compounds of formula (I), formula (II) and formula (III) or the salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs or polymorphs thereof as active ingredients, and an application thereof.

Description

R compound — OD 665 nm compound / OD 620 nm compound " OD 665 nm Controi / OD 620 nm control Rstdo= OD 665 nmstdo / OD 620 nmstdo - OD 665 nm control / OD 620 nm control inhibition rate (%) = (1 - R ComPound / Rstdo) * 100 Note: OD 665 nm compound is the absorbance value of each well of the compounds to be tested of the present disclosure at an emission wavelength of 665 nm. OD 620 nm compound is the absorbance value of each well of the compounds to be tested of the present disclosure at an emission wavelength of 620 nm. OD 665 nm control is the absorbance value of the blank control well at an emission wavelength of 665 nm. OD 620 nm control is the absorbance value of the blank control well at an emission wavelength of 620 nm. OD 665 nm stdo is the absorbance value of the solvent control well at an emission wavelength of 665 nm. OD 620 nm stdo is the absorbance value of the solvent control well at an emission wavelength of 620 nm.

[00435] The test results show that the CRBN binding activity IC50 value of lenalidomide (Lena-Nth) is 2.38 pM. The binding ability of the compounds of the present invention to CRBN is superior to or equivalent to that of lenalidomide. The results of the binding affinity test are shown in Table 5 below. Table 5. HTRF inhibitory activity (IC50, pM) of the compounds of the present invention Compound No. HTRF IC50 (pM) Compound No. HTRF IC50 (pM) Lena-NH2 2.38 GT-03100 9.80 GT-03106 4.04 GT-03075 5.09 GT-03109 3.55 GT-03210 2.69 GT-03077 5.20 GT-03211 9.80 GT-03108 8.75 GT-03076 0.65

[00436] Determination of half inhibitory concentration (IC50) of the compounds against tumor cells:

[00437] Cell cultures

[00438] The tumor cells used herein were cultured in a cell culture medium listed in table 6 at 37°C in an incubator with 5% CO2. Prior to experimentation, all cells used were correctly identified by STR profiling, and tested negative for mycoplasma through routine screenings. Table 6. Tumor cells and cell culture medium used in the present disclosure Cell line Cell culture medium used CCRF-CEM RPMI 1640 culture medium supplemented with 10% FBS, as well as penicillin at a final concentration of 100 U / mL and streptomycin at a final concentration of 100 pg / mL Kasumi-1 WSU-DLCL2 MM.1R MGC80-3 Daudi SU-DHL-6 TMD8 SW620 L-15 culture medium supplemented with 10% FBS, as well as penicillin at a final concentration of 100 U / mL and streptomycin at a final concentration of 100 pg / mL DU-145 EMEM culture medium supplemented with 10% FBS, as well as penicillin at a final concentration of 100 U / mL and streptomycin at a final concentration of 100 pg / mL LNcap F-12K culture medium supplemented with 10% FBS, as well as penicillin at a final concentration of 100 U / mL and streptomycin at a final concentration of 100 pg / mL PC-3 A549 HEP3B2.7-1 MEM culture medium supplemented with 10% FBS, as well as penicillin at a final concentration of 100 U / mL and streptomycin at a final concentration of 100 pg / mL

[00439] Assay method:

[00440] IC50 values of the compounds of the present disclosure (including the compounds in Table 4 and compounds of examples 1-72) were measured using the Meilun Cell Counting Kit-8 kit from Dalian Meilun Biotech Co., Ltd. Assay details are as follows: tumor cells were seeded in a 96-well plate at a density listed in Table 7. After 24h, 100 pL of the inoculated cells were treated with 0.5pL of the compounds of the present disclosure (including the compounds in Table 4 and compounds of examples 1-72) at 10 different successively decreasing concentrations (starting at the highest concentration of lOpM; 5-fold serial dilutions). After the cells were treated with the compounds of the present disclosure for a period of time (the treatment times listed in Table 7), the cell viability detection reagent was added to the culture medium for cell viability assessment according to the instructions provided with the CCK-8 kit. DMSO served as the negative control, and corresponding commercial inhibitors (including Enzalutamide (CAS No.: 915087-33-1); Ribociclib (CAS No.: 1211443-58-1); Dasatinib (CAS No.: 302962-49-8)) were used as the positive control, both of which treated the cells using the same protocol as that of the compounds of the present disclosure. The growth inhibition of the compounds of the present disclosure on cells was plotted by Prism Graphpad software, and the IC50 values of the compounds of the present disclosure were calculated therefrom. Results were shown in Tables 8-10 below. Table 7. Seeding protocol and treatment time for tumor cells Cells Cells seeding protocol The times for treating cells with the compounds of the present disclosure (hours) Kasumi-1 cells were seeded in 100 pL RPMI1640 medium containing serum at a density of 10,000 cells / well 72h MM.1R SU-DHL-6 TMD8 CCRF-CEM cells were seeded in 100 pL RPMI1640 medium containing serum at a density of 4000 cells / well 96h WSU-DLCL2 MGC80-3 Daudi DU-145 cells were seeded in 100 pL EMEM medium containing serum at a density of 4000 cells / well 96h SW620 cells were seeded in 100 pL L-15 medium containing serum at a density of 4000 cells / well 96h LNcap cells were seeded in 100 pL F-12K medium containing serum at a density of 4000 cells / well 96h PC-3 A549 HEP3B2.7-1 cells were seeded in 100 pL MEM medium containing serum at a density of 4000 cells / well 96h Table 8. IC50 values (in nM) of the compounds of examples of the present disclosure, designed based on the AR inhibitors, for inhibiting the proliferation of tumor cells Comp. No. / names LNcap PC-3 DU-145 MM.1 R wsu-DLCL 2 MGC8 0-3 SW620 A549 CCRF-CEM Hep3B 2.1-7 Enzaluta mide >1000 0 >1000 0 >1000 0 >1000 0 >10000 GT-03339 B B B B A - GT-03490 B D B B B - GT-03488 A+ A A+ A+ A A+ GT-03489 B D C B B B GT-03486 B B B A B B - GT-03487 B D B B B - GT-02765 A+ A+ A B A+ A+ A+ A+ A+ GT-03773 B GT-03016 c c c D D B A GT-03449 A c B A B A GT-03450 B D B c B GT-03451 B D B B C GT-03427 C D - B B GT-03471 C - - D B B GT-03425 A c B A A+ A+ GT-03426 A - B - A A+ GT-03481 B - - B B B A+ GT-03403 C B B - E C - GT-03404 C - - - B B GT-03402 A A A - B - B GT-03482 A B B B A B GT-03494 A D - A A B A GT-03400 B B B - C B GT-03401 C B C - D B GT- B B B - C - - - - B 03399 GT-03398 A A+ A - - A+ A Table 9. IC50 values (in nM) of the compounds of examples of the present disclosure, designed based on the CDK4 / 6 inhibitors, for inhibiting the proliferation of tumor cells Comp. No. / names SW620 Ribociclib >10000 GT-03651 B Table 10. IC50 values (in nM) of the compounds of examples of the present disclosure, designed based on the BCR-ABL inhibitors, for inhibiting the proliferation of tumor cells Comp. No. / names Daudi Kasumi-1 SU-DHL-6 TMD8 Dasatinib B A+ A+ A+ GT-03630 - A+ B - GT-03628 - B - - GT-03631 B B A+ - GT-03538 B B A+ A+ GT-03629 - B B - GT-03627 - B B - GT-03632 A A+ A+ - GT-03537 B A A+ A+ Note: In Tables 8-10, the symbols A+, A, B, C, D, and E are defined as follows: A+ < 50 nM; 50 nM < A < 100 nM; 100 nM < B < 500 nM; 500 nM < C < 1000 nM; 1000 nM < D < 5000 nM; 5000 nM <E< 10000 nM; symbol represents undetected.

[00441] The results indicate that the compounds of the present invention (including the compounds in Table 4 and Examples 1-72) can inhibit the proliferation of tumor cells (as shown in Tables 8-10 and Figure 1), with inhibitory effects superior to or comparable with the corresponding positive control drugs (including enzalutamide, ribociclib, and dasatinib), as well as degradation effect better than that of the corresponding positive control drugs.

[00442] Determination of Half-Maximal Target Protein Degradation Concentration (DC50) of the compounds of the present disclosure to target proteins

[00443] Western-blot assay

[00444] (1) Cell seeding: tumor cells (human prostate cancer cells 22RV1 or human prostate cancer cells C4-2) were added to a 6-well plate at a cell density of 2.5xlO5 / mL. The total volume of cell suspension in each well is 2mL. The compounds of the present disclosure (including the compounds in table 4 and the compounds of example 1-72) to be tested were set at 5 concentration gradients of InM, 2nM, lOnM, 20nM and 50nM, respectively. Meanwhile, DMSO solvent (containing 0 nM of the compounds to be tested) was set as a negative control.

[00445] (2) Protein collecting: after treating the cells with the compounds for 24 hours, the cell culture medium was removed. The cells were washed with 1ml of PBS, followed by removing the PBS and sequentially addition of lOOpL of RAPI lysis buffer (containing protease inhibitors). The mixture was placed on ice. The lysed cells were scraped off using a cell scraper, and transferred into a 1.5ml EP tube. Following this, the tube was placed on ice for 30-60 min, and centrifuged at 12,000 rpm for 5 min. The supernatant was aspirated as the extracted total cell protein. Protein concentrations were measured using the Bradford method, and bromophenol blue was incorporated as a loading dye.

[00446] (3) Electrophoresis: 15pg of the proteins collected after cell lysis were loaded for electrophoresis. Electrophoresis set at a constant voltage of 80V for 15min, and once the dye entered the separating gel, the voltage was adjusted to 120V for 40min.

[00447] (4) Membrane transfer: filter paper and nitrocellulose membrane (NC membrane) were prepared in an appropriate size. Then the filter paper and NC membrane were soaked in the transfer electrophoresis buffer. They were then placed in the electrophoresis tank in the following order: "filter paper-gel-NC membrane-filter paper," and the membrane was transferred with a constant current of 400mA for Ih. Subsequent antibody incubation and development are performed according to the antibody instructions provided by Cell Signaling Technology.

[00448] Determining Half-Maximal Degradation Concentration (DCso) value (the drug concentration required for degrading proteins by 50%, abbreviated as DCso) reads method: comparing the grayscale values of the Western blotting bands for the drug treatment with those of the Western blotting bands after treatment with blank DMSO. The DCso is identified within the range of drug concentrations where the grayscale value matches half of the grayscale value of the corresponding Western blotting band after treatment with blank DMSO.

[00449] Calculation of the DCso values can be performed using ImageJ to measure the grayscale values of Western blotting bands after drug treatment. A curve fitting the relationship between drug concentration and grayscale values is then generated to estimate the drug concentration corresponding to half of the grayscale value. A curve is then fitted to the relationship between drug concentration and grayscale values, allowing estimation of the drug concentration that corresponds to half of the grayscale value.

[00450] The present invention assessed the effects of the compounds of the present disclosure (including compounds in Table 4 and compounds of examples 1-72) on the protein expression levels of full-length androgen receptor (AR-FL) and androgen receptor splice variant 7 (AR-V7) in human prostate cancer cell lines 22RV1 and C4-2. Human prostate cancer cell line 22RV1 highly expresses AR-FL and AR-V7 splice variant, while human prostate cancer cell line C4-2 highly expresses AR-FL. The expression of AR-V7 splice variant, which lacks the LBD domain, represents one of the significant mechanisms that contribute to resistance against the AR antagonist enzalutamide. The Western-blot detection results were shown in Figures 2-3.

[00451] Experimental results demonstrate that, compared with the DMSO control group, the compounds of the present invention (including compounds in Table 4 and compounds of examples 172) exhibit a significant degradation effect on both AR-FL and the AR-V7 splice variant.

[00452] The basic principles, main features and advantages of the present disclosure are shown and described above. Those skilled in the art should understand that the present disclosure is not limited by the foregoing embodiments, and they can make various changes, substitutions and alterations herein without departing from the spirit and scope of the present disclosure. These changes, substitutions and alterations fall within the scope of the present disclosure. The claimed scope of the present disclosure is defined by the appended claims and their equivalents.

Claims

1. A compound of Formula (I)Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;Rs, Re, R7 and Rs are the same or different and each independently represent R9, hydrogen, deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or Cbealkynyl, wherein one to three of Rs, Re, R7 and Rs represents R9;R9 represents R-U- group, whereinU represents a bond, or U represents N(Rio) or O, wherein Rio represents H or optionally deuterated C1-6 alkyl;R represents optionally substituted nitrogen-containing heterocyclyl, said optionally substituted nitrogen-containing heterocyclyl is optionally substituted nitrogen-containing monocyclic heterocyclyl or optionally substituted nitrogen-containing bridged heterocyclyl;whereinwhen two to four of Rs, Re, R7, and Rs independently represent R9, the compound of Formula (I) is optionally partially or fully deuterated; orwhen only one of Rs, Re, R7, and Rs represents R9, the compound of Formula (I) is optionally partially or fully deuterated;wherein in case that only one of Rs, Re, R7, and Rs represents R9 and the compound of Formula (I) is not deuterated:when R represents optionally substituted nitrogen-containing bridged heterocyclyl, the following compounds are excluded:5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopyridin-3-yl)isoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopyridin-3-yl)-6-fluoroisoindoline-1,3-di one;5-(2,5-diazabicyclo[2.2.1 ]heptan-2-yl)-2-(2,6-dioxopyridin-3-yl)-6-fluoroisoindoline-1,3-di one;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(8-azabicyclo[3.2.1]octan-3-yl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; and 3-(5-(9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonan-7-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; orwhen A represents CO and one of Re and R? represents R9, where R represents substituted nitrogen-containing monocyclic heterocyclyl, and the other one of Re and R7, as well as Rs and Rs each independently represent hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, Ci-6 alkyl, Cue alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, one to three of the other one of Re and R7 as well as Rs and Rs represents halogen, and the nitrogen-containing monocyclic heterocyclyl is substituted with one or more substituents selected from the group consisting of hydroxy, amino, mercapto, nitro, halogen, cyano, C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene, C1-6 alkyl-NH-, C1-6 alkyl-NHC(O)-, C1-6 alkyl-C(O)NH- or any combination thereof;when A represents CO and one of Re and R7 represents R9, where R represents unsubstituted nitrogen-containing monocyclic heterocyclyl, the other one of Re and R7 represents hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, and Rs and Rs each independently represent halogen;when A represents CO and one of Rs and Rs represents R9, where R represents substituted nitrogen-containing monocyclic heterocyclyl, and the other one of Rs and Rs, as well as Re and R7 each independently represent hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, Ci-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, one to three of the other one of Rs and Rs as well as Re and R7 represents halogen, and the nitrogen-containing monocyclic heterocyclyl is substituted with one or more substituents selected from the group consisting of hydroxy, amino, mercapto, nitro, halogen, cyano, CHO, C1-6 alkyl, halogenated Ci-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 alkyl-NH-, NH2-C1-6 alkylene, C1-6 alkyl-NHC(O)-, C1-6 alkyl-C(O)NH- or any combination thereof;when A represents CO and one of Rs and Rs represents R9, where R represents unsubstituted nitrogen-containing monocyclic heterocyclyl, the other one of Rs and Rs and / or R7 each independently represent halogen, and Re represents hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl;when A represents CH2 and one of Re and R7 represents R9, where R represents substituted nitrogen-containing monocyclic heterocyclyl, and the other one of Re and R7, as well as Rs and Rs each independently represent hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, one to three of the other one of Re and R7 as well as R5 and Rs represents halogen, and the nitrogen-containing monocyclic heterocyclyl is substituted with one or more substituents selected from the group consisting of hydroxy, amino, mercapto, nitro, halogen, CHO, cyano, C1-6 alkyl, halogenated Ci-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 alkyl-NH-, NH2-C1-6 alkylene, C1-6 alkyl-NHC(O)-, C1-6 alkyl-C(O)NH- or any combination thereof;when A represents CH2 and one of Re and R7 represents R9, where R represents unsubstituted nitrogen-containing monocyclic heterocyclyl, Rs represents halogen, and the other one of Re and R7 and / or Rs each independently represent halogen, hydroxy, mercapto, nitro, amino, cyano, C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl;when A represents CH2 and one of Rs and Rs represents R9, where R represents substituted nitrogen-containing monocyclic heterocyclyl, and the other one of Rs and Rs, as well as Re and R7 each independently represent hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, Ci-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, one to three of the other one of Rs and Rs as well as Re and R7 represent halogen, and the nitrogen-containing monocyclic heterocyclyl is substituted with one or more substituents selected from the group consisting of hydroxy, amino, mercapto, nitro, halogen, CHO, cyano, C1-6 alkyl, halogenated C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 alkyl-NH-, NH2-C1-6 alkylene, C1-6 alkyl-NHC(O)-, C1-6 alkyl-C(O)NH- or any combination thereof; orwhen A represents CH2 and one of Rs and Rs represents R9, where R represents unsubstituted nifrogen-containing monocyclic heterocyclyl, and the other one of Rs and Rs, as well as Re and R7 each independently represent hydrogen, halogen, hydroxy, mercapto, nitro, amino, cyano, C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, the other one of Rs and Rs, as well as Re and R7 are not simultaneously hydrogen, and when Re is halogen, the other one of Rs and Rs, as well as R7 are not simultaneously hydrogen.

2. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (1-1) or Formula (1-2):Formula (1-1)            or           Formula (I-2)wherein A, Ri, R2, R3, R4, Rs, Re, R7 and Rs are as defined in claim 1.

3. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein when two to four of Rs,Re, R7 and Rs independently represent R9, the compound of Formula (I) is optionally partially deuterated, for example, carrying 1 to 20 deuterium atom, or the compound of Formula (I) is optionally fully deuterated.

4. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein when only one of Rs, Re, R7 and Rs represents R9, the compound of Formula (I) is partially deuterated, for example, carrying 1 to 15 deuterium atom, or the compound of Formula (I) is fully deuterated.

5. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein the nitrogen-containing monocyclic heterocyclyl or nitrogen-containing bridged heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, CHO, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof.

6. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, whereinthe nitrogen-containing monocyclic heterocyclyl is a 4- to 10-membered monocyclic heterocyclyl group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl or diazacyclooctyl; orthe nitrogen-containing bridged heterocyclyl is a C5-20 bridged heterocyclyl group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., azabicyclo [3.1.1 ]heptanyl,          azabicyclo[2.

2. l]heptanyl,          azabicyclo[3.2.1 ]octanyl,azabicyclo[2.2.2]octanyl, diazabicyclo [3.

1. l]heptanyl,        diazabicyclo[2.2.1 ]heptanyl,diazabicyclo[3.2.1]octanyl or diazabicyclo[2.2.2]octanyl, such as the following groups:1< / VWwherein the nitrogen-containing monocyclic heterocyclyl and nitrogen-containing bridged heterocyclyl are optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, CHO, optionallydeuterated Ci-6 alkyl, halogenated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof.

7. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enrichedanalogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein R9 represents thefollowing groups:

8. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, which is selected from:5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;5-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(3-azabicyclo [3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l, 3-dione;5-(8-azabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(2-azabicyclo[2.2.1]heptan-5-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(2-azabicyclo[2.2.2]octan-5-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -di one;5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline- 1,3-dione;5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline- 1,3-dione;5-((1 S,4S)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline- 1,3-dione;5-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-6-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,7-trifluoro-6-(piperazin-l-yl-2,2,3,3,5,5,6,6-<7s)isoindoline-l,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;6-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4,7-difluoroisoindoline-1,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;6-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;6-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4,7-difluoroisoindoline-1,3-dione;5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4,6-difluoroisoindoline-1,3-dione;5-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;6-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-l,3-dione;6-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-l,3-dione;5-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,7-trifluoro-6-(piperazin-l-yl)isoindoline-1,3-dione;6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;6-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline- 1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-l,3-dione;6-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-l,3-dione;5-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-l,3-dione;5-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-l,3-dione;5-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline- 1,3-dione;6-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;6-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;6-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-l,3-dione;5-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-l,3-dione;5-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-l,3-dione;5-(3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline- 1,3-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((lR,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((1 S,4S)-2,5-diazabicyclo[2.

2. l]heptan-2-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3 -(5-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3-azabicyclo[3.

2. l]octan-8-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-1 -yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-1 -yl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3 -(5-(2,6-dimethylpiperazin-1 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-1 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6,7-difluoro-l-oxo-5-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(4,7-difluoro-l-oxo-5-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(4,6,7-trifluoro-l-oxo-5-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-4,7-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-8-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,8-diazabicyclo[3.

2. l]octan-3-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(6,7-difluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(4,7-difluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(4,6-difluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3>5,5,6,6-6?8)isoindolin-2-yl)piperidine-2,6-dione;3-(4,6,7-trifluoro-l-oxo-5-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(2,6-dimethylpiperazin-l-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-l-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-l-yl)-4,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-l-yl)-4,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(3,5-dimethylpiperazin-l-yl)-4,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;4-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;4-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-fluoro-4-(piperazin-l-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-fluoro-7-(piperazin-l-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-7-(piperazin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-4-(piperazin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,7-difluoro-4-(piperazin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,6-trifluoro-7-(piperazin-l-yl)isoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-7-fluoroisoindoline-1,3 -di one;7-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6-difluoroisoindoline-1,3 -dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,7-difluoroisoindoline-1,3 -dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-5-fluoroisoindoline-1,3 -di one;4-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-7-fluoroisoindoline-1,3 -di one;7-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3-dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-3-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6-difluoroisoindoline-1,3 -dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-3-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,7-difluoroisoindoline-1,3 -dione;4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3 -dione;4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3-dione;4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-l,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-l,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-l,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-l,3-dione;4-(2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline- 1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-7-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,7-difluoro-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,6-trifluoro-7-(piperazin-l-yl-2,2,3,3,5,5,6,6-<7s)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-4-(piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-7-(piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-4-(piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-y 1)-5,7-difluoro-4-(piperidin-4-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,6-trifluoro-7-(piperidin-4-yl)isoindoline-1,3-dione;4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5-fluoroisoindoline-1,3 -di one;4-(3-azabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-7-fluoroisoindoline-1,3 -di one;7-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3 -dione; 4-(3-azabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione; 4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,7-difluoroisoindoline-1,3 -dione; 4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-5-fluoroisoindoline-1,3 -di one;4-(6-azabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-7-fluoroisoindoline-1,3 -di one;7-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3 -dione; 4-(6-azabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione; 4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-5,7-difluoroisoindoline-1,3 -dione; 4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;7-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3 -dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3 -dione;4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline- 1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline- 1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline- 1,3-dione;7-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-5,7-difluoroisoindoline-1,3-dione;4-(3,5-dimethylpiperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-5,6,7-trifluoroisoindoline-1,3-dione;3-(4-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.

2. l]octan-8-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.

2. l]octan-3-yl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5-fluoro-l-oxo-4-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-4-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(6,7-difluoro-l-oxo-4-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6-difluoro-l-oxo-4-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3 -(5,7-difluoro-1 -oxo-4-(piperazin-1 -yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6,7-trifluoro-l-oxo-4-(piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-5,6-difluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-5,7-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-5,6,7-trifluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-5,6-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-5,7-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,6-diazabicyclo [3.1.1 ]heptan-3-yl)-5,6,7-trifluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(( 1 R,5S)-3,8-diazabicyclo[3.2.1 ]octan-8-yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-8-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-1 -yl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(2,6-dimethylpiperazin-l-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-fluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(6,7-difluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5,7-difluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6-difluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6,7-trifluoro-l-oxo-4-(piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindolin-2-yl)piperidine-2,6-dione;3-(5-fluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(6,7-difluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6-difluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5,7-difluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3-(5,6,7-trifluoro-l-oxo-4-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione;3 -(4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3-azabicyclo[3.1.1]heptan-6-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3-azabicyclo[3.1.1]heptan-6-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-5,6-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-5,7-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(3 -azabicyclo [3.1.1 ]heptan-6-yl)-5,6,7-trifluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(6-azabicyclo[3.1.1]heptan-3-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(6-azabicyclo[3.1.1]heptan-3-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-5,6-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-5,7-difluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-(6-azabicyclo [3.1.1 ]heptan-3 -yl)-5,6,7-trifluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((lR,5S,8r)-3-azabicyclo[3.2.1]octan-8-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-6,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-5,6-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(3,5-dimethylpiperidin-4-yl)-5,7-difluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; and3-(4-(3,5-dimethylpiperidin-4-yl)-5,6,7-trifluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione.

9. A compound of Formula (II)oFormula (II)or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Rb)n indicates that benzene ring is substituted with n Rb substituents, and each Rb are the same or different and each independently represent hydrogen, deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl or C2-6alkynyl;(Ra)m indicates that the benzene ring is substituted with m Ra substituents, and each Ra are the same or different and each independently represents the structure of the following formula:W-LIN-U2-Rc-Ui- ,whereinUi and U2 are the same or different and each independently represent a bond, N(Rd) or O, wherein Ra represents H or optionally deuterated C1-6 alkyl;Rc represents optionally substituted nitrogen-containing monocyclic heterocyclylene or optionally substituted nitrogen-containing bridged heterocyclylene;W represents hydrogen, optionally substituted nitrogen-containing monocyclic heterocyclyl, optionally substituted nitrogen-containing bridged heterocyclyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted aryl, C2-6 alkenyl, C2-6 alkynyl, a leaving group, CHO, COOH, NH2, hydroxy or mercapto; andwherein in case that the compound of Formula (II) is partially or fully deuterated:when W represents optionally substituted nitrogen-containing monocyclic heterocyclyl, optionally substituted nitrogen-containing bridged heterocyclyl, optionally substitutedcycloalkyl, optionally substituted heteroaryl or optionally substituted aryl, LIN represents a bond, optionally substituted methylene, or optionally substituted linear or branched C2-30 alkylene, wherein one or more groups Re and / or one or more groups Rf and / or any combination of one or more groups Re and Rf are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re, Rf, or a combination of Re and Rf; wherein each Re are selected from the group consisting of O, N(Rg), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Rg), N(Rg)C(O), or N(Rg)C(O)N(Rg), where each Rg independently represent H or C1-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, the two or more groups Re are not directly connected to each other; and wherein each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; orwhen W represents hydrogen, C2-6 alkenyl, C2-6 alkynyl, a leaving group, CHO, COOH, NH2, hydroxy or mercapto, LIN represents optionally substituted methylene, or optionally substituted linear or branched C2-30 alkylene, wherein one or more groups Re and / or one or more groups Rf and / or any combination of one or more groups Re and Rf are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re, Rf, or a combination of Re and Rf; wherein each Re are selected from the group consisting of O, N(Rg), C(0), C(0)0, 0C(0), S(0), S(0)2, S(O)2NH, NHS(O)2, C(0)N(Rg), N(Rg)C(0), or N(Rg)C(0)N(Rg), where each Rg independently represent H or C1-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, the two or more groups Re are not directly connected to each other; and wherein each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with asubstituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; orin case that the compound of Formula (II) is not deuterated, LIN represents optionally substituted methylene, and W represents optionally substituted nitrogen-containing monocyclic heterocyclyl or optionally substituted nitrogen-containing bridged heterocyclyl; andm represents an integer of 1, 2, 3 or 4, n represents an integer of 0, 1, 2 or 3, and the sum of m and n is an integer of 1, 2, 3 or 4;with the proviso that when the compound of Formula (II) is not deuterated, the following compounds are excluded:3-(4,6-difluoro-l-oxo-5-(4-(piperidin-4-ylmethyl)piperazin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3 -yl)-5-(4-(piperidin-4-ylmethyl)piperazin-1 -yl)isoindoline-1,3 -dione;3-(4-chloro-l-oxo-5-(4-(piperidin-4-ylmethyl)piperidin-l-yl)isoindolin-2-yl)piperidine-2,6-dione;5-(4-(azetidin-3-ylmethyl)piperazin-1 -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperidin-3 -y 1)-5-(3 -(piperazin-1 -ylmethyl)azetidin-1 -yl)isoindoline-1,3 -di one.

10. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9, wherein the compound of Formula (II) is also of Formula (II-1) or Formula (11-2):n(Rb) OR R3 R2r          n(Rb) ,OR R3 R2rm(Ra) H-               Z=° m(Ra) H-^^""A NH                  Z^NHO                       OFormula (11)-1 or            Formula (ll)-2wherein A, Ri, R2, R3, R4, Ra, Rb, m, and n are as defined in claim 9.

11. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, whereinwhen the compound of Formula (II) is partially deuterated (for example, carrying 1 to 20 deuterium atoms) or fully deuterated, and W represents optionally substituted nitrogen-containing monocyclic heterocyclyl, optionally substituted nitrogen-containing bridged heterocyclyl, optionally substituted cycloalkyl, optionally substituted heteroaryl or optionally substituted aryl, LIN represents a bond, optionally substituted methylene, or optionally substituted linear or branched C2-30 alkylene, wherein one or more groups Re and / or one or more groups Rf and / or any combination of one or more groups Re and Rf are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re, Rf, or a combination of Re and Rf; each Re are selected from the group consisting of O, N(Rg), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Rg), N(Rg)C(O), or N(Rg)C(O)N(Rg), where each Rg independently represent H or Ci-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, the two or more groups Re are not directly connected to each other; and each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxyl, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; orwhen the compound of Formula (II) is partially deuterated (for example, carrying 1 to 20 deuterium atom) or fully deuterated, and W represents hydrogen, C2-6 alkenyl, C2-6 alkynyl, a leaving group, CHO, COOH, NH2, hydroxy or mercapto, LIN represents optionally substituted methylene or optionally substituted linear or branched C2-30 alkylene, wherein one or more groups Re and / or one or more groups Rf and / or any combination of one or more groups Re and Rf are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re, Rf, or a combination of Re and Rf; each Re are selected from the group consisting of O, N(Rg), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Rg), N(Rg)C(O), or N(Rg)C(O)N(Rg), where each Rg independently represent H or C1-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, the two or more groups Re are not directly connected to each other; and each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxyl, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; orwhen the compound of Formula (II) is not deuterated, LIN represents optionally substituted methylene, and W represents optionally substituted nitrogen-containing monocyclic heterocyclyl or optionally substituted nitrogen-containing bridged heterocyclyl;wherein the methylene and the linear or branched C2-30 alkylene are optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof.

12. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein Rc represents the following groups:monocyclic C3-10 heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene or diazacyclooctylene; orC5-20 bridged heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., azabicyclo[3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1 ]heptanylene, diazabicyclo[2.2.1 ]heptanylene, diazabicyclo[3.2.1 ]octanylene or diazabicyclo[2.2.2]octanylene, such as the following groups:wherein symbol * indicates the point of attachment to Ui,wherein the monocyclic C3-10 heterocyclylene and the C5-20 bridged heterocyclylene group are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, CHO, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof.

13. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein Rc represents the following groups:wherein symbol * indicates the point of attachment to Ui.

14. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein W representsthe following groups:monocyclic C3-10 heterocyclyl group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl or diazacyclooctyl; orC5-20 bridged heterocyclyl group containing one nitrogen atom and optionally a heteroatomselected from nitrogen, oxygen, and sulfur, e.g., azabicyclo [3.1.1 ]heptanyl, azabicyclo[2.2.1]heptanyl,          azabicyclo[3.2.1]octanyl,          azabicyclo[2.2.2]octanyl,diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl ordiazabicyclo[2.2.2]octanyl, such as the following groups:Y^NHHN\Y^Y^nkhn^AWWsaturated or partially unsaturated monocyclic or bicyclic or polycyclic C3-20 cycloalkyl, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-IH-indenyl, C7-11 spiro-cycloalkyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptyl or bicyclo[2.2.1]heptenyl; orheteroaryl, e.g., 5- to 20-membered monocyclic or bicyclic C5-20 aromatic ring group containingone or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, andsulfur, e.g., furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,l,3]oxadiazolyl, benzo[2,l,3]thiadiazolyl, benzo[l,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[l,5-a]pyridyl, pyrazolo[l,5-a]pyrimidinyl, imidazo[l,2-a]pyridyl, lH-pyrrolo[3,2-b]pyridyl, lH-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,l-b]thiazolyl or imidazo[2,l-b]thiazolyl; orC5-14 aryl optionally containing one or more fused rings, e.g., phenyl, naphthyl or fluorenyl; and wherein the C3-10 heterocyclyl, C5-20 bridged heterocyclyl, C3-20 cycloalkyl, heteroaryl and C5-14 aryl are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, CHO, COOH, N3, methanesulfonyloxy, trifluoromethanesulfonyloxy, p-toluenesulfonyloxy, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally substituted C3-8 cycloalkyl (e.g., substituted with one or more substituents selected from the group consisting of deuterium, halogen, amino, hydroxy, mercapto, cyano, CHO, COOH, N3, methanesulfonyloxy, trifluoromethanesulfonyloxy and p-toluenesulfonyloxy), optionally substituted 4- to 9-membered heterocyclyl (e.g., substituted with one or more substituents selected from the group consisting of deuterium, halogen, amino, hydroxy, mercapto, cyano, CHO, COOH, N3, methanesulfonyloxy, trifluoromethanesulfonyloxy and p-toluenesulfonyloxy), C1-6 alkoxy, deuterated C1-6 alkyl-O-, C1-6 alkyl-NH-, deuterated C1-6 alkyl-NH-, NH2-C1.6 alkylene, Ci-6 alkyl-NHC(O)-, deuterated Ci-6 alkyl-NHC(O)-, Ci-6 alkyl-C(O)NH-, deuterated Ci-6 alkyl-C(O)NH- or any combination thereof.

15. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein LIN represents the structure of the following formula:#-Ci-3o alkylene-;#-(C(R^(Ra2)h^#-(C(R^(Ra2))nHRda^#-(C(Ra^(Ra2))nHRe(C(Ra3)(Ra4))n2)m^#-(C(Ra^(Ra2))^^#-(C(Ra^(Ra2))nHRiO^#-(C(Ra^(Ra2))nHRi(C(Ra3)(Ra4))n2)m^#-(C(Ral)(Ra2))ni-(Re-Rf-(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))nHRda^#-(C(Ra^(Ra2))nHR^^^                      or#-(C(R^(Ra2))^wherein each Re are selected from the group consisting of O, N(Rg), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Rg), N(Rg)C(O), or N(Rg)C(O)N(Rg), where each Rg independently represent H or Ci-6 alkyl;wherein each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-Ci-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;a hydrogen atom of one or more CH2 groups of the C1-30 alkylene group is optionally replaced with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-Ci-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;Ral, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7, and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-Ci-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

16. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein LIN represents the structure of the following formula:#-(CTRal)(Ra2fh^#-(C(Ral)(Ra2))ni-(O(C(Ra3)(Ra4))n2)mi-(O(^^^#-(C(Ra^(Ra2))nHO(C(Ra3)(Ra4))^^#-(C(Ral)(Ra2))ni-(N(Rg)(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))nr(W^#-(C(Ral)(Ra2))ni-(N(Rg)(C(Ra3)(Ra4))n2)mi-(N(R^^#-(C(Ral)(Ra2))ni-(C(O)N(RgH#-(C(Ra^(Ra2))nr(W#-(C(Ra^(Ra2))nr(CO(C(Ra7)(Ra8))n4)m3-;#-(C(Ral)(Ra2))ni-(C(O)N(Rg)-(C(Ra3)(Ra4))n2)mi-(O-(C(Ra5)(Ra6))n3)m2-;#-(C(R^(Ra2))nrW#-(C(Ral)(Ra2))ni-(N(Rg)C(O)-(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))nHN(^#-(C(Ral)(Ra2))ni-(N(Rg)C(O)-(C(Ra3)(Ra4))n2)mi<^#-(C(Ral)(Ra2))ni-N(Rg)C(O)-(C(Ra3)(Ra4))n2-(O(C(Ra5)(Ra6))n3)mi-;#-(C(Ral)(Ra2))ni-N(Rg)C(O)N(Rg)-(C(Ra3)(Ra4))n2-;#-(C(Ral)(Ra2^^#-(C(Ra^(Ra2a#-(C(Ra^(Ra2))nHaryle^#-(C(Ral)(Ra2))ni-(heterocyclyle^#-(C(Ral)(Ra2))ni-(heterocyclylene-(C(Ra3)(Ra4))n2)mi-^#-(C(Ral)(Ra2))ni-(heteroarylene<^#-(C(Ral)(Ra2))ni-(heteroarylene-(C(Ra3)(Ra4))n2)mi^#-(C(Ra^(Ra2a                              or#-(C(Ra^(Ra2))nHcycloalkylene-(a^wherein each Rg independently represent H or Ci-6 alkyl;the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;Ral, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

17. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein LIN represents the following groups:#-CH2-, #-(CH2)2-, #-(CH2)3-, #-(CH2)4-, #-(CH2)5-, #-(CH2)6-, #-(CH2)7-, #-(CH2)8-, #-(CH2)9-, #-(CH2)io-, #-(CH2)ii-, #-(CH2)i2-, #-(CH2)i3-, #-(CH2)i4-, #-(CH2)i5-, #-(CH2)i6-, #-(CH2)i7-, #-(CH2)18-, #-(CH2)i9-, #-(CH2)20-, #-(CH2)2i-, #-(CH2)22-, #-(CH2)25-, or #-(CH2)3o-;#-CH2-0-CH2-, #-CH2-O-(CH2)2-, #-(CH2)i-O-(CH2)3-, #-(CH2)i-O-(CH2)4-, #-(CH2)i-O-(CH2)5-, #-(CH2)i-O-(CH2)6-, #-(CH2)i-O-(CH2)7-, #-(CH2)i-O-(CH2)8-, #-(CH2)i-O-(CH2)9-, #-(CH2)i-0-(CH2)io-, #-(CH2)2-O-(CH2)1-, #-(CH2)2-O-(CH2)2-, #-(CH2)2-O-(CH2)3-, #-(CH2)2-O-(CH2)4-, #-(CH2)2-O-(CH2)5-, #-(CH2)2-O-(CH2)6-,  #-(CH2)2-O-(CH2)7-,  #-(CH2)2-O-(CH2)8-,  #-(CH2)2-O-(CH2)9-,  #-(CH2)2-O-(CH2)io-, #-(CH2)2-O-(CH2)ii-, #-(CH2)2-O-(CH2)i2-, #-(CH2)3-O-(CH2)i-, #-(CH2)3-O-(CH2)2-, #-(CH2)3-O-(CH2)3-,  #-(CH2)3-O-(CH2)4-,  #-(CH2)3-O-(CH2)5-,  #-(CH2)3-O-(CH2)6-,  #-(CH2)3-O-(CH2)7-, #-(CH2)4-O-(CH2)i-, #-(CH2)4-O-(CH2)2-, #-(CH2)4-O-(CH2)3-, #-(CH2)4-O-(CH2)4-, #-(CH2)4-O-(CH2)5-,  #-(CH2)4-O-(CH2)6-,  #-(CH2)5-O-(CH2)i-,  #-(CH2)5-O-(CH2)2-,  #-(CH2)5-O-(CH2)3-, #-(CH2)5-O-(CH2)4-, #-(CH2)5-O-(CH2)5-, #-(CH2)6-O-(CH2)i-, #-(CH2)6-O-(CH2)2-, #-(CH2)6-O-(CH2)3-,  #-(CH2)6-O-(CH2)4-,  #-(CH2)7-O-(CH2)i-,  #-(CH2)7-O-(CH2)2-,  #-(CH2)7-O-(CH2)3-, #-(CH2)8-O-(CH2)i-, #-(CH2)8-O-(CH2)2-, #-CH(CH3)-O-(CH2)i-, #-CH(CH3)-O-(CH2)2-, #-CH(CH3)-O-(CH2)3-, #-CH(CH3)-O-(CH2)4-, #-CH(CH3)-O-(CH2)5-, #-CH(CH3)-O-(CH2)6-, #-CH(CH3)-O-(CH2)7-, #-CH(CH3)-O-(CH2)8-, #-CH(CH3)-O-(CH2)9-, #-CH(CH3)-0-(CH2)io-, #-ch2-(O(CH2)2)2-, #-CH2-(O(CH2)2)3-, #-CH2-(O(CH2)2)4-, #-CH2-(O(CH2)2)5-, #-CH2-(O(CH2)2)6-, #-ch2-(O(CH2)2)7-, #-CH2-(O(CH2)2)8-, #-CH2-(O(CH2)2)9-, #-CH2-(0(CH2)2)io-, #-CH2-(O(CH2)2)i-OCH2-, #-CH2-(O(CH2)2)2-OCH2-, #-CH2-(O(CH2)2)3-OCH2-, #-CH2-(O(CH2)2)4-OCH2-, #-CH2-(O(CH2)2)5-OCH2-, #-CH2-(O(CH2)2)6-OCH2-, #-CH2-(O(CH2)2)7-OCH2-, #-CH2-(O(CH2)2)8-OCH2-, #-ch2-(O(CH2)2)9-OCH2-, #-CH2-(0(CH2)2)io-OCH2-, #-(CH2)2-(O(CH2)2)2-, #-(CH2)2-(O(CH2)2)3-, #-(CH2)2-(O(CH2)2)4-, #-(CH2)2-(O(CH2)2)5-, #-(CH2)2-(O(CH2)2)6-, #-(CH2)2-(O(CH2)2)7-, #-(CH2)2-(O(CH2)2)8-,  #-(CH2)2-(O(CH2)2)9-,  #-(CH2)2-(0(CH2)2)io-,  #-(CH2)3-(O(CH2)2)2-,  #-(CH2)3-(O(CH2)2)3-,   #-(CH2)3-(O(CH2)2)4-,   #-(CH2)3-(O(CH2)2)5-,   #-(CH2)3-(O(CH2)2)6-,   #-(CH2)3-(O(CH2)2)7-,  #-(CH2)3-(O(CH2)2)8-,  #-(CH2)3-(O(CH2)2)9-,  #-(CH2)3-(0(CH2)2)io-,  #-(CH2)4-(O(CH2)2)2-,   #-(CH2)4-(O(CH2)2)3-,   #-(CH2)4-(O(CH2)2)4-,   #-(CH2)4-(O(CH2)2)5-,   #-(CH2)4-(O(CH2)2)6-,   #-(CH2)4-(O(CH2)2)7-,   #-(CH2)4-(O(CH2)2)8-,   #-(CH2)4-(O(CH2)2)9-,   #-(CH2)4-(0(CH2)2)io-, #-CH2-(O(CH2)3)2-, #-CH2-(O(CH2)3)3-, #-CH2-(O(CH2)3)4-, #-CH2-(O(CH2)3)5-, #-CH2-(O(CH2)3)6-, #-CH2-(O(CH2)3)7-, #-CH2-(O(CH2)3)8-, #-CH2-(O(CH2)3)9-, #-CH2-(0(CH2)3)io-, #-(CH2)2-(O(CH2)3)2-, #-(CH2)2-(O(CH2)3)3-, #-(CH2)2-(O(CH2)3)4-, #-(CH2)2-(O(CH2)3)5-, #-(CH2)2-(O(CH2)3)6-, #-(CH2)2-(O(CH2)3)7-, #-(CH2)2-(O(CH2)3)8-, #-(CH2)2-(O(CH2)3)9-, #-(CH2)2-(0(CH2)3)io-, #-(CH2)3-(O(CH2)3)2-, #-(CH2)3-(O(CH2)3)3-, #-(CH2)3-(O(CH2)3)4-, #-(CH2)3-(O(CH2)3)5-, #-(CH2)3-(O(CH2)3)6-, #-(CH2)3-(O(CH2)3)7-, #-(CH2)3-(O(CH2)3)8-, #-(CH2)3-(O(CH2)3)9-, #-(CH2)3-(0(CH2)3)io-, #-CH2-O-(CH2)2-O-(CH2)3-, #-CH2-(O(CH2)2)2-(O(CH2)3)2-, #-CH2-(O(CH2)2)3-(O(CH2)3)3-, #-CH2-(O(CH2)2)4-(O(CH2)3)4-, #<H2<O(CH2)2)5-(O(CH2)3)5-, #-CH2-(O(CH2)2)6-(O(CH2)3)6-, #-(CH2)2-O-(CH2)2-O-(CH2)3-, #<CH2)2<O(CH2)2MO(CH2)3)2-, #-(CH2)2-(O(CH2)2)3-(O(CH2)3)3-, #<CH2MO(CH2)2)4-(O(CH2)3)4-, #-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-, #-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-, #<CH2)3-O<CH2)2-O-(CH2)3-> #-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-, #-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-,     #-(CH2)3-(O(CH2)2)4-(O(CH2)3)4-,     #-(CH2)3-(O(CH2)2)5-(O(CH2)3)5-, #-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-, #-CH2-O-(CH2)3-O-(CH2)2-, #-CH2-(O(CH2)3)2-(O(CH2)2)2-, #<H2-(O(CH2)3)3-(O(CH2)2)3-, #-CH2<O(CH2)3MO(CH2)2)4-, #-CH2-(O(CH2)3)5-(O(CH2)2)5-, #-CH2-(O(CH2)3)6-(O(CH2)2)6-, #<CH2)2-O-(CH2)3-O-(CH2)2-, #-(CH2)2-(O(CH2)3)2-(O(CH2)2)2-,   #-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-,   #-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-,   #-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-, #-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-, #-(CH2)3-O-(CH2)3-O-(CH2)2-, #-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-, #-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-, #-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-, #-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-, #-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-, #-CH2-O-(CH2)2-O-CH2-, #-(CH2)2-O-(CH2)2-O-CH2-, #-(CH2)2-(O(CH2)2)2-O-(CH2)3-, #-(CH2)2-(O(CH2)2)3-O-(CH2)3-, #-(CH2)2-(O(CH2)2)4-O-(CH2)3-, #-(CH2)5-(O(CH2)2)2-O-(CH2)5-, #-(CH2)5-(O(CH2)2)2-O-(CH2)6-, #-(CH2)i-N(Rg)-(CH2)i-, #-(CH2)i-N(Rg)-(CH2)2-, #-(CH2)i-N(Rg)-(CH2)3-, #-(CH2)i-N(Rg)-(CH2)4-, #-(CH2)i-N(Rg)-(CH2)5-, #-(CH2)i-N(Rg)-(CH2)6-, #-(CH2)i-N(Rg)-(CH2)7-, #-(CH2)i-N(Rg)-(CH2)8-, #-(CH2)i-N(Rg)-(CH2)9-, #-(CH2)i-N(Rg)-(CH2)io-, #-(CH2)2-N(Rg)-(CH2)i-, #-(CH2)2-N(Rg)-(CH2)2-, #-(CH2)2-N(Rg)-(CH2)3-, #-(CH2)2-N(Rg)-(CH2)4-, #-(CH2)2-N(Rg)-(CH2)5-, #-(CH2)2-N(Rg)-(CH2)6-, #-(CH2)2-N(Rg)-(CH2)7-, #-(CH2)2-N(Rg)-(CH2)8-, #-(CH2)2-N(Rg)-(CH2)9-, #-(CH2)2-N(Rg)-(CH2)io-, #-(CH2)2-N(Rg)-(CH2)ii-, #-(CH2)2-N(Rg)-(CH2)i2-, #-(CH2)3-N(Rg)-(CH2)i-, #-(CH2)3-N(Rg)-(CH2)2-, #-(CH2)3-N(Rg)-(CH2)3-, #-(CH2)4-N(Rg)-(CH2)i-, #-(CH2)4-N(Rg)-(CH2)2-, #-(CH2)4-N(Rg)-(CH2)3-, #-(CH2)4-N(Rg)-(CH2)4-, #-(CH2)5-N(Rg)-(CH2)i-, #-(CH2)5-N(Rg)-(CH2)2-, #-(CH2)5-N(Rg)-(CH2)3-, #-(CH2)5-N(Rg)-(CH2)4-, #-(CH2)5-N(Rg)-(CH2)5-, #-(CH2)6-N(Rg)-(CH2)i-, #-(CH2)6-N(Rg)-(CH2)2-, #-(CH2)6-N(Rg)-(CH2)3-, #-(CH2)7-N(Rg)-(CH2)i-, #-(CH2)7-N(Rg)-(CH2)2-, #-(CH2)7-N(Rg)-(CH2)3-, #-(CH2)8-N(Rg)-(CH2)i-, #-(CH2)8-N(Rg)-(CH2)2-, #-(CH2)8-N(Rg)-(CH2)3-, #-CH(CH3)-N(Rg)-(CH2)i-, #-CH(CH3)-N(Rg)-(CH2)2-, #-CH(CH3)-N(Rg)-(CH2)3-, #-CH(CH3)-N(Rg)-(CH2)4-, #-CH(CH3)-N(Rg)-(CH2)5-, #-CH(CH3)-N(Rg)-(CH2)6-, #-CH(CH3)-N(Rg)-(CH2)7-, #-CH(CH3)-N(Rg)-(CH2)8-, #-CH(CH3)-N(Rg)-(CH2)9-, #-CH(CH3)-N(Rg)-(CH2)io-, #-CH2C(O)NHCH2-, #-(CH2)2C(O)NH(CH2)2-,       #-(CH2)2C(O)NH(CH2)3-,       #-(CH2)2C(O)NH(CH2)4-,       #-(CH2)2C(O)NH(CH2)5-,       #-(CH2)3C(O)NH(CH2)3-,       #-(CH2)3C(O)NH(CH2)4-,       #-(CH2)4C(O)NH(CH2)4-,       #-(CH2)5C(O)NH(CH2)5-,       #-(CH2)6C(O)NH(CH2)7-,       #-(CH2)6C(O)NH(CH2)6-,      #-(CH2)7C(O)NH(CH2)7-,      #-(CH2)8C(O)NH(CH2)8,      u-(CH2)9C(O)NH(CH2)9-, #-(CH2)ioC(0)NH(CH2)io-, #-(CH2)2C(O)NH(CH2)2-O-(CH2)2-, #-CH2NHC(O)CH2-, #-(CH2)2NHC(O)(CH2)2-, #-(CH2)2NHC(O)(CH2)3-, #-(CH2)2NHC(O)(CH2)4-, #-(CH2)2NHC(O)(CH2)5-,       #-(CH2)3NHC(O)(CH2)3-,       #-(CH2)3NHC(O)(CH2)4-,       #-(CH2)4NHC(O)(CH2)4-,       #-(CH2)5NHC(O)(CH2)5-,       #-(CH2)6NHC(O)(CH2)7-,       #-(CH2)6NHC(O)(CH2)6-, #-(CH2)7NHC(O)(CH2)7-, #-(CH2)8NHC(O)(CH2)8, #-(CH2)9NHC(O)(CH2)9-, #-(CH2)i0NHC(O)(CH2)i0-, #-(CH2)4NHC(O)(CH2)8-, #-(CH2)2NHC(O)(CH2)2-O-(CH2)2-, #-(CH2)4NHC(O)CH2-, #-CH2-piperidinylene-CH2-, #-CH2-piperidinylene-(CH2)2-, #-CH2-piperidinylene-(CH2)3-, #-CH2-piperidinylene-(CH2)4-, #-CH2-piperidinylene-(CH2)5-, #-CH2-piperidinylene-(CH2)6-, #-CH2-piperidinylene-(CH2)7-, #-CH2-piperidinylene-(CH2)8-, #-(CH2)2-piperidinylene-(CH2)i-, #-(CH2)2-piperidinylene-(CH2)2-, #-(CH2)2-piperidinylene-(CH2)3-, #-(CH2)2-piperidinylene-(CH2)4-, #-(CH2)2-piperidinylene-(CH2)5-, #-(CH2)2-piperidinylene-(CH2)6-, #-(CH2)2-piperidinylene-(CH2)7-, #-(CH2)2-piperidinylene-(CH2)8-, #-(CH2)3-piperidinylene-CH2-, #-(CH2)3-piperidinylene-(CH2)2-, #-(CH2)3-piperidinylene-(CH2)3-, #-(CH2)3-piperidinylene-(CH2)4-, #-(CH2)3-piperidinylene-(CH2)5-, #-(CH2)3-piperidinylene-(CH2)6-, #-(CH2)3-piperidinylene-(CH2)7-, #-(CH2)3-piperidinylene-(CH2)8-, #-(CH2)4-piperidinylene-CH2-, #-(CH2)4-piperidinylene-(CH2)2-, #-(CH2)4-piperidinylene-(CH2)3-, #-(CH2)4-piperidinylene-(CH2)4-, #-(CH2)4-piperidinylene-(CH2)5-, #-(CH2)4-piperidinylene-(CH2)6-, #-(CH2)4-piperidinylene-(CH2)7-, #-(CH2)4-piperidinylene-(CH2)8-, #-(CH2)s-piperidinylene-(CH2)i-, #-(CH2)5-piperidinylene-(CH2)2-, #-(CH2)5-piperidinylene-(CH2)3-, #-(CH2)s-piperidinylene-(CH2)4-, #-(CH2)5-piperidinylene-(CH2)5-, #-(CH2)5-piperidinylene-(CH2)6-, #-(CH2)s-piperidinylene-(CH2)7-, #-(CH2)5-piperidinylene-(CH2)8-, #-(CH2)6-piperidinylene-(CH2)i-, #-(CH2)6-piperidinylene-(CH2)2-, #-(CH2)6-piperidinylene-(CH2)3-, #-(CH2)6-piperidinylene-(CH2)4-, #-(CH2)6-piperidinylene-(CH2)5-, #-(CH2)6-piperidinylene-(CH2)6-, #-(CH2)6-piperidinylene-(CH2)7-, #-(CH2)6-piperidinylene-(CH2)8-, #-(CH2)7-piperidinylene-(CH2)i-, #-(CH2)7-piperidinylene-(CH2)2-, #-(CH2)7-piperidinylene-(CH2)3-, #-(CH2)7-piperidinylene-(CH2)4-, #-(CH2)7-piperidinylene-(CH2)8-, #-(CH2)8-piperidinylene-CH2-, #-(CH2)8-piperidinylene-(CH2)2-, #-(CH2)8-piperidinylene-(CH2)3-, #-(CH2)8-piperidinylene-(CH2)4-, #-(CH2)8-piperidinylene-(CH2)5-, #-(CH2)8-piperidinylene-(CH2)6-, #-(CH2)8-piperidinylene-(CH2)7-, #-(CH2)8-piperidinylene-(CH2)8-, #-CH2-N(Rg)-CH2-piperidinylene-CH2-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)2-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)3-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)4-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)5-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)4-, piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-,#-CH2-N(Rg)-CH2-piperidinylene-(CH2)7-,#-CH2-N(Rg)-(CH2)2-piperidinylene-CH2-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)3-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)5-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)7-,#-(CH2)2-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)3-,#-CH2-N(Rg)-CH2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-(CH2)2-N(Rg)-CH2-#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)4-, piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)4-, piperidinylene-(CH2)6-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)5-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)7-,#-(CH2)3-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)3-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)4-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)4-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)5-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)6-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)7-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)8-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)5-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)7-,#-(CH2)2-N(Rg)-CH2-#-(CH2)2-N(Rg)-CH2-#-(CH2)3-N(Rg)-CH2-#-(CH2)3-N(Rg)-CH2-#-(CH2)4-N(Rg)-CH2-#-(CH2)4-N(Rg)-CH2-#-(CH2)5-N(Rg)-CH2-#-(CH2)6-N(Rg)-CH2-#-(CH2)7-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)8-,piperazinylene-(CH2)3-,piperazinylene-(CH2)6-,#-CH2-piperazinylene-CH2-,#-CH2-piperazinylene-(CH2)4-,#-CH2-piperazinylene-(CH2)7-,#-CH2-piperazinylene-(CH2)2-,#-CH2-piperazinylene-(CH2)5-,#-CH2-piperazinylene-(CH2)8-,#-ch2-#-ch2-#-(CH2)2-piperazinylene-(CH2)i-,#-(CH2)2-piperazinylene-(CH2)2-, #-(CH2)2-piperazinylene-(CH2)3-, #-(CH2)2-piperazinylene-(CH2)4-, #-(CH2)2-piperazinylene-(CH2)s-, #-(CH2)2-piperazinylene-(CH2)6-, #-(CH2)2-piperazinylene-(CH2)7-, #-(CH2)2-piperazinylene-(CH2)s-, #-(CH2)3-piperazinylene-CH2-, #-(CH2)3-piperazinylene-(CH2)2-, #-(CH2)3-piperazinylene-(CH2)3-, #-(CH2)3-piperazinylene-(CH2)4-, #-(CH2)3-piperazinylene-(CH2)5-, #-(CH2)3-piperazinylene-(CH2)6-, #-(CH2)3-piperazinylene-(CH2)7-, #-(CH2)3-piperazinylene-(CH2)8-, #-(CH2)4-piperazinylene-CH2-, #-(CH2)4-piperazinylene-(CH2)2-, #-(CH2)4-piperazinylene-(CH2)3-, #-(CH2)4-piperazinylene-(CH2)4-, #-(CH2)4-piperazinylene-(CH2)s-, #-(CH2)4-piperazinylene-(CH2)6-, #-(CH2)4-piperazinylene-(CH2)7-, #-(CH2)4-piperazinylene-(CH2)s-, #-(CH2)5-piperazinylene-(CH2)i-, #-(CH2)s-piperazinylene-(CH2)2-, #-(CH2)s-piperazinylene-(CH2)3-, #-(CH2)5-piperazinylene-(CH2)4-, #-(CH2)5-piperazinylene-(CH2)s-, #-(CH2)s-piperazinylene-(CH2)6-, #-(CH2)5-piperazinylene-(CH2)7-, #-(CH2)s-piperazinylene-(CH2)8-, #-(CH2)6-piperazinylene-(CH2)i-, #-(CH2)6-piperazinylene-(CH2)2-, #-(CH2)6-piperazinylene-(CH2)3-, #-(CH2)6-piperazinylene-(CH2)4-, #-(CH2)6-piperazinylene-(CH2)5-, #-(CH2)6-piperazinylene-(CH2)6-, #-(CH2)6-piperazinylene-(CH2)7-, #-(CH2)6-piperazinylene-(CH2)8-, #-(CH2)7-piperazinylene-(CH2)i-, #-(CH2)7-piperazinylene-(CH2)2-, #-(CH2)7-piperazinylene-(CH2)3-, #-(CH2)7-piperazinylene-(CH2)4-, #-(CH2)7-piperazinylene-(CH2)s-, #-(CH2)8-piperazinylene-CH2-, #-(CH2)8-piperazinylene-(CH2)2-, #-(CH2)8-piperazinylene-(CH2)3-, #-(CH2)8-piperazinylene-(CH2)4-, #-(CH2)8-piperazinylene-(CH2)s-, #-(CH2)8-piperazinylene-(CH2)6-, #-(CH2)8-piperazinylene-(CH2)7-, or #-(CH2)8-piperazinylene-(CH2)8-;wherein the piperidinylene and the piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;each Rg independently represent H or C1-6 alkyl;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

18. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopicallyenriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9 or 10, wherein Ra representsthe following groups:or                         h ;wherein the groups are optionally partially or fully deuterated.

19. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9, which is selected from:2-(2,6-dioxopiperidin-3-yl)-5-(3-(piperidin-4-ylmethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperi din-3 -yl)-5-fluoro-6-(3 -(piperidin-4-ylmethy 1)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-5-(6-(piperidin-4-ylmethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(6-(piperidin-4-ylmethyl)-3,6-diazabicyclo[3. l.l]heptan-3 -yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-5-(3-(piperidin-4-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-(piperidin-4-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-(8-(piperidin-4-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(8-(piperidin-4-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-(5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-5-((lR,4R)-5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-((lR,4R)-5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((lS,4S)-5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperi din-3 -yl)-5-fluoro-6-(( 1S ,4S)-5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y l)-5-(5-(piperidin-4-ylmethy 1)-2,5-diazabicyclo [2.2.2] octan-2-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-(piperidin-4-ylmethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-5-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-5-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-6-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,7-trifluoro-6-(4-(piperidin-4-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)isoindoline-l,3-dione;5-(2,6-dimethyl-4-(piperidin-4-ylmethyl)piperazin-l-yl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-1,3-dione;5-(2,6-dimethyl-4-(piperidin-4-ylmethyl)piperazin-l-yl)-2-(2,6-dioxopiperi din-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3,5-dimethyl-4-(piperidin-4-ylmethyl)piperazin-l-yl)-2-(2,6-dioxopiperi din-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3,5-dimethyl-4-(piperidin-4-ylmethyl)piperazin-l-yl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-y 1)-5-( l-(piperidin-4-ylmethyl)piperidin-4-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3 -yl)-5-fluoro-6-( 1 -(piperidin-4-ylmethyl)piperidin-4-y l)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((R)-3-((piperidin-4-ylmethyl)amino)piperidin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((S)-3-((piperidin-4-ylmethyl)amino)piperidin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((S)-l-(piperi din-4-ylmethyl)piperidin-3-yl)amino)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((R)-l-(piperidin-4-ylmethyl)piperidin-3-yl)amino)isoindoline-1,3-dione;5-(3 -(azetidin-3 -ylmethyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(3 -(azetidin-3 -ylmethyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(6-(azetidin-3 -ylmethyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(6-(azetidin-3 -ylmethyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(3-(azetidin-3-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(3-(azetidin-3-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-(azetidin-3-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(8-(piperidin-4-ylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)isoindoline-1,3 -dione;5-(5-(azetidin-3 -ylmethyl)-2,5-diazabicyclo [2.2.1 ]heptan-2-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((lR,4R)-5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-1,3 -dione;5-((lR,4R)-5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-((lS,4S)-5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-((1 S,4S)-5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-(azetidin-3-ylmethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3 -dione;6-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;5-(4-(azetidin-3-ylmethyl)piperazin-l-yl-2,2,3,3,5,5,6,6-d8)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-(azetidin-3-ylmethyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(l-(azetidin-3-ylmethyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(1 -(azetidin-3 -ylmethyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3-((azetidin-3-ylmethyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((S)-3 -((azetidin-3 -ylmethyl)amino)piperi din-1 -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-1 -(azetidin-3 -ylmethyl)piperidin-3 -yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; and5-(((R)-l-(azetidin-3-ylmethyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione.

20. A compound of Formula (III)PBM-R^W1-LIN-ULMFormula (III)or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,wherein PBM-RhW1- represents a targeting moiety capable of binding protein, ULM represents a E3 ubiquitin ligase ligand moiety, LIN is a linker moiety, and PBM-RhW1- is covalently bonded to ULM through LIN;ULM represents the structure of Formula (ULM):n^Rb\\>^R4 R3 R2Ri bu2—Rc-Ui-t-        \ / NH OFormula (ULM)wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Rb)n indicates that benzene ring is optionally substituted with n Rb groups, and each Rb are the same or different and each independently represent hydrogen, deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl;n represents an integer of 0, 1, 2 or 3;Ui and U2 are the same or different and each independently represent a bond, N(Rd) or O, wherein Ra represents H or optionally deuterated C1-6 alkyl;Rc represents optionally substituted nitrogen-containing monocyclic heterocyclylene or optionally substituted nitrogen-containing bridged heterocyclylene;LIN represents a bond, optionally substituted methylene, or optionally substituted linear or branched C2-30 alkylene, wherein one or more groups Re and / or one or more groups Rf and / or any combination of one or more groups Re and Rf are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re, Rf, or a combination of Re and Rf; wherein each Re are selected from the group consisting of O, N(Rg), C(0), C(0)0, 0C(0), S(0), S(0)2, S(O)2NH, NHS(O)2, C(0)N(Rg), N(Rg)C(0), or N(Rg)C(0)N(Rg), where each Rg independently represent H or C1-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkylene group, the two or more groups Re are not directly connected to each other; and wherein each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof;W1 is t interconnected rings W2 and represented by the following formula:each ring W2 are the same or different and each independently represent optionally substituted nitrogen-containing monocyclic heterocyclylene, optionally substituted nitrogencontaining bridged heterocyclylene, or optionally substituted cycloalkylene, andt represents an integer of 1 or 2; andR1 represents:a bond, -0-, optionally substituted C1-6 alkylene (e.g., methylene), -N(Rla)-R2a-*** (e.g.,h 1 ), -O-R2a-*** (e.g.,******), -C(0)NH-R2a-***, or -NHC(0)-R2a -*** (e.g.,0), wherein symbol *** indicates the point of attachment toW1, Rla is H or C1-6 alkyl, and R2a is optionally substituted C1-6 alkylene or optionally substitutedCi-6 alkenylene; orCe-io aryl or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the Ce-io aryl and heteroaryl areeach optionally substituted with one or more R3a, and each R3a are the same or different and are each independently halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy;wherein one or more hydrogens of the compound of Formula (III) are optionally replaced with deuterium;wherein when the compound of Formula (III) is not deuterated, the following compounds areexcluded:Formula (IV-1)in Formula (IV-1), R1 represents a bond, W1 represents piperidinylene, LIN representsmethylene, Rc represents piperazinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb representsfluoro, n represents an integer of 1, 2 or 3, and Ui and U2 are the same or different and each independently represent a bond, NH or O; orin Formula (IV-1), R1 represents a bond, W1 represents piperazinylene, LIN represents methylene, Rc represents piperidinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb representsfluoro, n represents an integer of 1, 2 or 3, and Ui and U2 are the same or different and eachindependently represent a bond, NH or O;Formula (IV-2)in Formula (IV-2), R1 represents a bond, W1 represents piperidinylene, LIN represents methylene, Rc represents piperazinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb represents fluoro, n represents an integer of 1, 2 or 3, and Ui and U2 are the same or different and each independently represent a bond, NH or O; orin Formula (IV-2), R1 represents a bond, W1 represents piperazinylene, LIN represents methylene, Rc represents piperidinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb representsfluoro, and n represents an integer of 1, 2 or 3, and Ui and U2 are the same or different and each independently represent a bond, NH or O;OHFormula (IV-3)in Formula (IV-3), R1 represents a bond or -O-CH2-CH2-, W1 represents piperidinylene, LIN represents methylene, Rc represents piperazinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb represents hydrogen, and Ui and U2 are the same or different and each independently represent a bond, NH or O; orin Formula (IV-3), R1 represents a bond or -O-CH2-CH2-, W1 represents piperazinylene, LIN represents methylene, Rc represents piperidinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb represents hydrogen, and Ui and U2 are the same or different and each independently represent a bond, NH or O;andFormula (IV-4)in Formula (IV-4), R1 represents a bond or represents -O-CH2-CH2-, W1 represents piperidinylene, LIN represents methylene, Rc represents piperazinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb represents hydrogen, and Ui and U2 are the same or different and each independently represent a bond, NH or O; orin Formula (IV-4), R1 represents a bond or represents -O-CH2-CH2-, W1 represents piperazinylene, LIN represents methylene, Rc represents piperidinylene, 2,5-diazabicyclo[2.2.1]heptanylene, 8-azabicyclo[3.2.1]octanylene, or 9-ethyl-3-methyl-3,9-diazabicyclo[3.3.1]nonanylene, Rb represents hydrogen, and Ui and U2 are the same or different and each independently represent a bond, NH or O.

21. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein the PBM is asmall molecule ligand targeting EGFR, CDK4 / 6, ALK, RET, FAK, BCR-ABL, BTK, AR, ER orBET.

22. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopicallyenriched analogs, prodrugs, or polymorphs thereof as claimed in claim 21, wherein the PBMcomprises the structures of the following formula:Formula (PBM-1)            Formula (PBM-2)Formula (PBM-3)Formula (PBM-4)             Formula (PBM-5)R14Formula (PBM-6)             Formula (PBM-7)        Formula (PBM-8)              Formula (PBM-9)             Formula (PBM-10)Formula (PBM-12)Formula (PBM-13)       Formula (PBM-14)Formula (PBM-15)Formula (PBM-11)or Formula (PBM-19)wherein(R2)pi indicates that the benzene ring in Formula (PBM-1) is substituted with pl R2, and each R2 are the same or different and each independently represent halogen or halogenated Ci-6 alkyl;(R3)P2 indicates that the quinazoline ring in Formula (PBM-1) is substituted with p2 R3, and each R3 are the same or different and each independently represent Ci-io alkyl, deuterated Ci-io alkyl, Ci-ioalkoxy, heterocyclyloxy, or -NHC(O)R4, wherein R4 is Cmo alkyl or C2-10 alkenyl, e.g., R3 represents 0           __ __methyl, methoxy, h or          , such as ^'o     ;pl represents an integer of 1, 2, 3, 4 or 5;p2 represents an integer of 1, 2 or 3;(R5)P3 indicates that the benzene ring in Formula (PBM-2) is substituted with p3 R5, and each R5 are the same or different and each independently represent Cmo alkyl, deuterated Cmo alkyl, Cmo alkoxy, or -NHC(O)R4, wherein R4 is Cmo alkyl, deuterated Cmo alkyl or C2-10 alkenyl, e.g., R5 0represents methyl, methoxy or h ;p3 represents an integer of 1, 2, 3 or 4;(R6)P4 indicates that the IH-indole ring in Formula (PBM-2) is substituted with p4 R6, and each R6 are the same or different and each independently represent Cmo alkyl or deuterated Cmo alkyl;p4 represents an integer of 0, 1, 2 or 3;(R7)P5 indicates that the benzene ring in Formula (PBM-3) is substituted with p5 R7, and each R7 are the same or different and each independently represent halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, or cyano;p5 represents an integer of 2, 3, 4 or 5;R8 represents Co io aryl or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the Ce-io aryl and heteroaryl are each optionally substituted with one or more R4a, and each R4a are the same or different and are each independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;R9 represents Cmo alkyl (e.g.,    ) or deuterated Cmo alkyl;0                  (R5a)p6R10 represents n% / or X— / , wherein (R5a)P6 indicates that the piperidine ring is substituted with p6 R5a, and each R5a are the same or different and each independently represent deuterium, halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkoxy, NO2, NH2, or cyano, p6 represents an integer of 1, 2, 3, 4 or 5;(Rn)P7 indicates that the benzene ring and the pyridine ring in Formula (PBM-5) are each optionally substituted with p7 R11, and each R11 are the same or different and each independently represent halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, p7 represents an integer of 0, 1, 2 or 3;ring A in Formula (PBM-6) represents Ce io aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring A is optionally substituted with one or more R6a, and each R6a are the same or different and each independently represent deuterium, halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, C2-6 alkenyl, or C2-6 alkynyl;ring B in Formula (PBM-6) represents C3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring B is optionally substituted with one or more R7a, and each R7a are the same or different and each independently represent deuterium, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;ring C in Formula (PBM-6) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring C is optionally substituted with one or more R8a, and each R8a are the same or different and each independently represent deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;Xi in Formula (PBM-7) represents N or CR12, wherein R12 is hydrogen or represents a bond, and X2 represents CH or N;R13 is hydrogen or represents a bond, wherein when R13 represents a bond, Xi represents N or CH, and the nitrogen atom in the ring connected to R13 is directly connected to R1; or when R13 is hydrogen, Xi represents CR12, wherein R12 represents a bond, and the carbon atom in the ring connected to R12 is directly connected to R1;R14 represents -O-aryl, -O-heteroaryl, -Ci-3-alkylene-NHC(O)-heteroaryl, or -Ci-3-alkylene-C(O)NH-heteroaryl, wherein the aryl and heteroaryl are each independently optionally substituted with one or more R9a, and each R9a are the same or different and each independently represent deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;R15 represents deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl or -NHC(O)R17, wherein R17 is C1-10 alkyl or C2-10 alkenyl, e.g., R15 represents hydrogen, 0methyl, or H ;R16 represents hydrogen, cyano, or amino;X3 in Formula (PBM-8) represents CR21 or a fragment r21    ***, wherein symbol ## indicatesthe point of attachment to N atom adjacent to X3, symbol ### indicates the point of attachment to X4,and R21 represents deuterium, hydrogen, halogen, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, -C(O)-Ci-6 alkyl, -C(O)-deuterated Ci-6 alkyl, or -C(O)NR22R23, wherein R22 and R23 are the same or different and each independently represent hydrogen, Ci-6 alkyl or deuterated Ci-6 alkyl, and R22 and R23 are not simultaneously hydrogen;X4 in Formula (PBM-8) represents N or CR24, wherein R24 represents hydrogen, deuterium, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;X5 and Xe each independently represent CH or N;R18 represents a bond or optionally substituted heteroarylene (e.g., halogenated heteroarylene);R19 represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or optionally substituted C3-7 cycloalkyl;R20 and R25 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;R26 represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;R27 represents hydrogen, cyano, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;(R28)P8 indicates that the benzene ring in Formula (PBM-10) is substituted with p8 R28 substituents, and each R28 are the same or different and each independently represent halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p8 represents an integer of 1, 2, 3 or 4;R29 represents NR30R31, wherein R30 and R31 are the same or different and each independently represent hydrogen, C1-6 alkyl, or deuterated C1-6 alkyl;X7, Xs and X9 in Formula (PBM-11) are the same or different and each independently represent N or CH;(R32)P9 indicates that the 6-membered ring containing Xs and X9 in Formula (PBM-11) is optionally substituted with p9 R32 groups, and each R32 are the same or different and each independently represent halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p9 represents an integer of 0, 1, 2, 3 or 4;R33 represents halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;R34 represents -C(O)NHR35, -NHC(O)-R35, -S(O)2NHR35, -S(O)2R35 or -P(O)(R35)2, wherein each R35 are the same or different and each independently represent C1-6 alkyl or deuterated C1-6 alkyl;(R36)pio indicates that the benzene ring in Formula (PBM-12) is optionally substituted with plO R36 groups, and each R36 are the same or different and each independently represent halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;plO represents an integer of 0, 1, 2, 3 or 4;(R37)pii indicates that the benzene ring in Formula (PBM-13) is substituted with pl 1 R37 groups, and each R37 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl 1 represents an integer of 0, 1, 2, 3 or 4;(R38)pi2 indicates that the benzene ring in Formula (PBM-14) is substituted with pl2 R38 groups, and each R38 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl2 represents an integer of 0, 1, 2, 3 or 4;(R39)pi3 indicates that the 4-oxo-3,4-dihydroquinazoline ring in Formula (PBM-14) is substituted with pl3 R39 groups, and each R39 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p 13 represents an integer of 1, 2, 3 or 4;(R40)pi4 indicates that the benzene ring in Formula (PBM-15) is substituted with pl4 R40 groups, and each R40 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl4 represents an integer of 1, 2, 3 or 4;R41 represents halogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;(R42)pi5 indicates that the quinoline ring in Formula (PBM-16) is substituted with pl5 R42 groups, and each R42 are the same or different and each independently represent halogen, cyano, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl5 represents an integer of 2, 3 or 4;(R43)pi6 indicates that the benzene ring in Formula (PBM-16) is substituted with pl6 R43 groups, and each R43 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl6 represents an integer of 3 or 4;(R44)pi7 indicates that the benzene, pyrimidine and pyridine rings in Formula (PBM-17) are each optionally substituted with pl7 R44 groups, and each R44 are the same or different and each independently represent halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl7 represents an integer of 0, 1, 2, 3 or 4;one of R45, R46, R47 and R48 represents a bond, and the remaining are the same or different and each independently represent hydrogen, halogen, or hydroxy, wherein when one of R45, R46, R47 and R48 represents a bond, the benzene ring or methylene in Formula (PBM-18) connected to the bond is directly connected to R1;symbol connected to double bond in Formula (PBM-18) represents a bond in stereoconfiguration (cis or trans configuration);(R49)pi8 indicates that 1,2,3,4-tetrahydronaphthalene ring in Formula (PBM-19) is substituted with pl8 R49 groups, and each R49 are the same or different and each independently represent hydrogen, hydroxy, halogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;pl8 represents an integer of 0, 1, 2, 3 or 4; andone of R50 and R51 represents a bond, and another represents hydrogen, halogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl, wherein when one of R50 and R51 represents a bond, the benzene ring in Formula (PBM-19) connected to the bond is directly connected to R1.

23. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopicallyenriched analogs, prodrugs, or polymorphs thereof as claimed in claim 21, wherein the PBMrepresents the structures of the following formula:Formula (PBM-3-1) Formula (PBM-4-1) Formula (PBM-4-2) Formula (PBM-5-1)           Formula (PBM-6-1)Formula (PBM-8-3)Formula (PBM-9-1)Formula (PBM-10-1)Formula (PBM-11-1)Formula (PBM-11-2)Formula (PBM-11 -3)              Formula (PBM-11 -4)                Formula (PBM-11 -5)Formula (PBM-12-1)Formula (PBM-17-1)Formula (PBM-13-1) Formula (PBM-14-1)Formula (PBM-15-1) Formula (PBM-16-1)OHFormula (PBM-18-1) Formula (PBM-18-2)Formula (PBM-18-3) Formula (PBM-18-4) Formula (PBM-18-5)OHOHFormula (PBM-18-6)Formula (PBM-19-1) or Formula (PBM-6-3)24. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein the R1 represents the structures of the following formula:a bond, -O-, optionally substituted Ci-6 alkylene (e.g., methylene, ethylene, propylene, isopropylene, butylene, tert-butylene, pentylene and hexylene), -N(Rla)-R2a-*** (e.g., -N(CH3)-CH2CH2-***, -NH-CH2CH2-***), -O-R2a-*** (e.g., -O-(CH2)3-***, -O-CH2-*** and -O-(CH2)2-***), -C(O)NH-R2a-*** (e.g., -C(O)NH-(CH2)2-***, -C(O)NH-(CH2)3-***, -C(O)NH-CH=CH-CH2-***, and -C(O)NH-CH2-CH=CH-CH2-***, ), or -NHC(O)-R2a -*** (e.g., -NHC(O)-CH=CH-CH2-***, -NHC(O)-CH2-CH=CH-CH2-***, -NHC(O)-(CH2)2-***, and -NHC(O)-(CH2)3-***), wherein symbol *** indicates the point of attachment to W1, Rla is hydrogen or C1-6 alkyl, and R2a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene; orphenylene or naphthylene, wherein the phenylene or naphthylene is independently optionally substituted with one or more R3a, and each R3a are the same or different and each independentlyrepresent halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy; orfuranylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,l,3]oxadiazolylene, benzo[2,l,3]thiadiazolylene, benzo[l,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[l,5-a]pyridylene, pyrazolo[l,5-a]pyrimidinylene, imidazo[l,2-a]pyridylene, lH-pyrrolo[3,2-b]pyridylene, lH-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,l-b]thiazolylene, and imidazo[2,l-b]thiazolylene, with each group being independently optionally substituted with one or more R3a, and each R3a are the same or different and are each independently halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy.

25. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein W1 is t interconnected rings W2 and represented by the following formula:wherein each ring W2 are the same or different and each independently represent the following groups:monocyclic C3-10 heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene or diazacyclooctylene; orC5-20 bridged heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., azabicyclo[3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1 ]heptanylene, diazabicyclo[2.2.1 ]heptanylene, diazabicyclo[3.2.1 ]octanylene or diazabicyclo[2.2.2]octanylene, such as the following groups:C3-15 cycloalkylene, e.g., cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-IH-indenylene, C5-15 spiro-cycloalkylene, adamantanylene,noradamantanylene, bomylene, bicyclo[2.2.1]heptylene or bicyclo[2.2.1]heptenylene;wherein the monocyclic C3-10 heterocyclylene, C5-20 bridged heterocyclylene, and C3-15 cycloalkylene are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; andt represents an integer of 1 or 2.

26. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 25, wherein the W1 representsthe following groups:-i-nOnEn^-1-n(^n^n4 orwherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, or any combination thereof.

27. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein the R^W1represents the following groups:wherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, or any combination thereof.

28. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein the ULM represents the structures of Formula (ULM-1), (ULM-2), (ULM-3), (ULM-4), (ULM-5), (ULM-6), (ULM-7), (ULM-8), (ULM-9), or (ULM-10):Formula (ULM-1)               Formula (ULM-2)                Formula (ULM-3)             Formula (ULM-4)Formula (ULM-5)           Formula (ULM-6)Formula (ULM-7)Formula (ULM-8)Formula (ULM-9) or Formula (ULM-10)wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Rb)n indicates that benzene ring is optionally substituted with n Rb groups, and each Rb are the same or different and each independently represent hydrogen, deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, C2-6 alkenyl or C2-6alkynyl;n represents an integer of 0, 1, 2 or 3;Ui and U2 are the same or different and each independently represent a bond, N(Rd) or O, wherein Rd represents H or optionally deuterated C1-6 alkyl;Rc represents monocyclic C3-10 heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene or diazacyclooctylene; orRc represents C5-20 bridged heterocyclylene group containing one nitrogen atom and optionally a heteroatom selected from nitrogen, oxygen, and sulfur, e.g., azabicyclo[3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1 ]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene or diazabicyclo[2.2.2]octanylene, such as the following groups:wherein the monocyclic C3-10 heterocyclylene and C5-20 bridged heterocyclylene are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof.

29. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 28, wherein the Rc represents the following groups:wherein symbol * indicates the point of attachment to Ui.

30. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 28, wherein the ULM represents the structures of Formula (ULM-11), (ULM-12), (ULM-13), (ULM-14), (ULM-15), (ULM-16), (ULM-17), (ULM-18), (ULM-19), (ULM-20), (ULM-21) or (ULM-22):Formula (ULM-11)                Formula (ULM-12)Formula (ULM-13)                 Formula (ULM-14)Formula (ULM-15)              Formula (ULM-16)                    Formula (ULM-17)                       Formula (ULM-18)Formula (ULM-19)Formula (ULM-20)                 Formula (ULM-21)or          Formula (ULM-22)wherein A, (Rb)n, Rb, Rc, Ui, and U2 are as defined in claim 27.

31. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein the ULMrepresents the structure of the following formula:

32. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 20-31, wherein the LIN represents the structures of the following formula:#-Ci-3o alkylene-;#-(C(Ral)(Ra2))ni-(Re(C(Ra3)(Ra4))n2)mi-;#-(C(Ral)(Ra2))nl-(Re(C(Ra3)(Ra4))n2)m^^#-(C(Ral)(Ra2))ni-(Re(C(Ra3)(Ra4))n2)mi-(Re(C(Ra5)^#-(CTRal)(Ra2)^#-(C(R^(Ra2))nH^#-(C(R^(Ra2))nHRi(aRa3)(Ra4^^^#-(C(Ra^(Ra2^#-(C(Ra^(Ra2))nHM#-(C(Ra^(Ra2^                       or#-(C(Ra^(Ra2))nH^wherein each Re are selected from the group consisting of O, N(Rg), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Rg), N(Rg)C(O), or N(Rg)C(O)N(Rg), where each Rg independently represent H or Ci-6 alkyl; wherein each Rf are selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;a hydrogen atom of one or more CH2 groups of the C1-30 alkylene group is optionally replaced with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6alkylene, optionally deuterated Ci-6 alkyl-NHC(O)-, optionally deuterated Ci-6 alkyl-C(O)NH-, or any combination thereof;Ral, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7, and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated Ci-6 alkyl, halogenated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

33. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 20-31, wherein LIN represents the structure of the following formula:#-(C(R^(Ra2a#-(C(R^(Ra2))nHO^^#-(C(Ra^(Ra2))nHO(C(Ra3)(R^#-(C(Ral)(Ra2))ni-(N(Rg)(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))^^#-(C(Ra^(Ra2))nr(N(Rg)(C(Ra3X#-(C(Ral)(Ra2))ni-(C(O)N(Rg)-(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))nr(W#-(C(Ra^(Ra2))nr(CO(C(Ra7)(Ra8))n4)m3_;#-(C(Ra^(Ra2))nHCW#-(C(Ral)(Ra2))ni-C(O)N(Rg)-(C(Ra3)(Ra4))n2-^#-(C(Ral)(Ra2))ni-(N(Rg)C(O)-(C(Ra3)(Ra4))n2)mi-;#-(C(Ral)(Ra2))ni-(N(Rg)C(O)-(C(Ra3)(Ra4))n2)mi-(O^#-(C(Ra^(Ra2))nHN(Rg^#-(C(Ra^(Ra2))nrN(^#-(C(Ral)(Ra2))ni-N(Rg)C(O)N(Rg)-(C(Ra3)(Ra4))n2-;#-(C(Ral)(Ra2))ni-C(O)-(C(Ra3)(Ra4))n2-;#-(C(Ral)(Ra2))ni-(arylene-(C(Ra3)(Ra4))n2)mi-;#-(C(Ral)(Ra2))ni-(arylene-(C(Ra3)(Ra4))n2)mi-arylene-(C(Ra5)(Ra6))n3-;#-(C(Ral)(Ra2))ni-(heterocyclylene-(C(Ra3)(Ra4))n2)mi-;#-(C(Ra^(Ra2))nHhelerocyclylene-(CT^#-(C(Ral)(Ra2))ni-(heteroaryl^#-(C(Ra^(Ra2))nHheleroarylene-(a^#-(C(Ra^(Ra2a                              or#-(C(Ra^(Ra2))nHcycloalkylene-(a^wherein each Rg independently represent H or Ci-6 alkyl;the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;Ral, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

34. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 20-31, wherein LIN represents the following groups:#-CH2-, #-(CH2)2-, #-(CH2)3-, #-(CH2)4-, #-(CH2)5-, #-(CH2)6-, #-(CH2)7-, #-(CH2)s-, #-(CH2)9-, #-(CH2)io-, #-(CH2)h-, #-(CH2)i2-, #-(CH2)i3-, #-(CH2)i4-, #-(CH2)i5-, #-(CH2)i6-, #-(CH2)i7-, #-(CH2)18-, #-(CH2)i9-, #-(CH2)20-, #-(CH2)2i-, #-(CH2)22-, #-(CH2)25-, or #-(CH2)30-; #-CH2-O-CH2-, #-CH2-O-(CH2)2-, #-(CH2)i-O-(CH2)3-, #-(CH2)i-O-(CH2)4-, #-(CH2)i-O-(CH2)5-, #-(CH2)i-O-(CH2)6-, #-(CH2)i-O-(CH2)7-, #-(CH2)i-O-(CH2)8-, #-(CH2)i-O-(CH2)9-, #-(CH2)i-0-(CH2)io-, #-(CH2)2-O-(CH2)i-, #-(CH2)2-O-(CH2)2-, #-(CH2)2-O-(CH2)3-, #-(CH2)2-O-(CH2)4-, #-(CH2)2-O-(CH2)5-, #-(CH2)2-O-(CH2)6-,  #-(CH2)2-O-(CH2)7-,  #-(CH2)2-O-(CH2)8-,  #-(CH2)2-O-(CH2)9-,  #-(CH2)2-O-(CH2)io-, #-(CH2)2-O-(CH2)h-, #-(CH2)2-O-(CH2)i2-, #-(CH2)3-O-(CH2)i-, #-(CH2)3-O-(CH2)2-, #-(CH2)3-O-(CH2)3-,  #-(CH2)3-O-(CH2)4-,  #-(CH2)3-O-(CH2)5-,  #-(CH2)3-O-(CH2)6-,  #-(CH2)3-O-(CH2)7-, #-(CH2)4-O-(CH2)i-, #-(CH2)4-O-(CH2)2-, #-(CH2)4-O-(CH2)3-, #-(CH2)4-O-(CH2)4-, #-(CH2)4-O-(CH2)5-,  #-(CH2)4-O-(CH2)6-,  #-(CH2)5-O-(CH2)i-,  #-(CH2)5-O-(CH2)2-,  #-(CH2)5-O-(CH2)3-, #-(CH2)5-O-(CH2)4-, #-(CH2)5-O-(CH2)5-, #-(CH2)6-O-(CH2)i-, #-(CH2)6-O-(CH2)2-, #-(CH2)6-O-(CH2)3-,  #-(CH2)6-O-(CH2)4-,  #-(CH2)7-O-(CH2)i-,  #-(CH2)7-O-(CH2)2-,  #-(CH2)7-O-(CH2)3-, #-(CH2)8-O-(CH2)i-, #-(CH2)8-O-(CH2)2-, #-CH(CH3)-O-(CH2)i-, #-CH(CH3)-O-(CH2)2-, #-CH(CH3)-O-(CH2)3-, #-CH(CH3)-O-(CH2)4-, #-CH(CH3)-O-(CH2)5-, #-CH(CH3)-O-(CH2)6-, #-CH(CH3)-O-(CH2)7-, #-CH(CH3)-O-(CH2)8-, #-CH(CH3)-O-(CH2)9-, #-CH(CH3)-0-(CH2)io-, #-ch2-(O(CH2)2)2-, #-CH2-(O(CH2)2)3-, #-CH2-(O(CH2)2)4-, #-CH2-(O(CH2)2)5-, #-CH2-(O(CH2)2)6-, #-ch2-(O(CH2)2)7-, #-CH2-(O(CH2)2)8-, #-CH2-(O(CH2)2)9-, #-CH2-(0(CH2)2)io-> #-CH2-(O(CH2)2)i-OCH2-, #-CH2-(O(CH2)2)2-OCH2-, #-CH2-(O(CH2)2)3-OCH2-, #-CH2-(O(CH2)2)4-OCH2-, #-CH2-(O(CH2)2)5-OCH2-, #-CH2-(O(CH2)2)6-OCH2-, #-CH2-(O(CH2)2)7-OCH2-, #-CH2-(O(CH2)2)8-OCH2-, #-ch2-(O(CH2)2)9-OCH2-, #-CH2-(O(CH2)2)i0-OCH2-, #-(CH2)2-(O(CH2)2)2-, #-(CH2)2-(O(CH2)2)3-, #-(CH2)2-(O(CH2)2)4-, #-(CH2)2-(O(CH2)2)5-, #-(CH2)2-(O(CH2)2)6-, #-(CH2)2-(O(CH2)2)7-, #-(CH2)2-(O(CH2)2)8-,  #-(CH2)2-(O(CH2)2)9-,  #-(CH2)2-(0(CH2)2)io-,  #-(CH2)3-(O(CH2)2)2-,  #-(CH2)3-(O(CH2)2)3-,   #-(CH2)3-(O(CH2)2)4-,   #-(CH2)3-(O(CH2)2)5-,   #-(CH2)3-(O(CH2)2)6-,   #-(CH2)3-(O(CH2)2)7-,  #-(CH2)3-(O(CH2)2)8-,  #-(CH2)3-(O(CH2)2)9-,  #-(CH2)3-(0(CH2)2)io-,  #-(CH2)4-(O(CH2)2)2-,   #-(CH2)4-(O(CH2)2)3-,   #-(CH2)4-(O(CH2)2)4->   #-(CH2)4-(O(CH2)2)5-,   #-(CH2)4-(O(CH2)2)6-,   #-(CH2)4-(O(CH2)2)7-,   #-(CH2)4-(O(CH2)2)8-,   #-(CH2)4-(O(CH2)2)9-,   #-(CH2)4-(0(CH2)2)io-, #-CH2-(O(CH2)3)2-, #-CH2-(O(CH2)3)3-, #-CH2-(O(CH2)3)4-, #-CH2-(O(CH2)3)5-, #-CH2-(O(CH2)3)6-, #-CH2-(O(CH2)3)7-, #-CH2-(O(CH2)3)8-, #-CH2-(O(CH2)3)9-, #-CH2-(0(CH2)3)io-, #-(CH2)2-(O(CH2)3)2-, #-(CH2)2-(O(CH2)3)3-, #-(CH2)2-(O(CH2)3)4-, #-(CH2)2-(O(CH2)3)5-, #-(CH2)2-(O(CH2)3)6-,   #-(CH2)2-(O(CH2)3)7-,   #-(CH2)2-(O(CH2)3)8-,   #-(CH2)2-(O(CH2)3)9-,   #-(CH2)2-(0(CH2)3)io-,  #-(CH2)3-(O(CH2)3)2-,  #-(CH2)3-(O(CH2)3)3-,  #-(CH2)3-(O(CH2)3)4-,  #-(CH2)3-(O(CH2)3)5-,   #-(CH2)3-(O(CH2)3)6-,   #-(CH2)3-(O(CH2)3)7-,   #-(CH2)3-(O(CH2)3)8-,   #-(CH2)3-(O(CH2)3)9-, #-(CH2)3-(0(CH2)3)io-, #-CH2-O-(CH2)2-O-(CH2)3-, #-CH2-(O(CH2)2)2-(O(CH2)3)2-, #-CH2-(O(CH2)2)3-(O(CH2)3)3-, #-CH2<O(CH2)2MO(CH2)3)4-, #<H2<O(CH2)2)5-(O(CH2)3)5-, #-CH2-(O(CH2)2)6-(O(CH2)3)6-, #-(CH2)2-O-(CH2)2-O-(CH2)3-, #-(CH2)2-(O(CH2)2)2-(O(CH2)3)2-, #-(CH2)2-(O(CH2)2)3-(O(CH2)3)3-, #-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-, #-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-, #-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-, #-(CH2)3-O-(CH2)2-O-(CH2)3-, #-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-, #-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-,     #-(CH2)3-(O(CH2)2)4-(O(CH2)3)4-,     #-(CH2)3-(O(CH2)2)5-(O(CH2)3)5-, #-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-, #-CH2-O-(CH2)3-O-(CH2)2-, #-CH2-(O(CH2)3)2-(O(CH2)2)2-, #-CH2-(O(CH2)3)3-(O(CH2)2)3-, #-CH2<O(CH2)3MO(CH2)2)4-, #-CH2-(O(CH2)3)5-(O(CH2)2)5-, #-CH2-(O(CH2)3)6-(O(CH2)2)6-, #-(CH2)2-O-(CH2)3-O-(CH2)2-, #-(CH2)2-(O(CH2)3)2-(O(CH2)2)2-,   #-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-,   #-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-,   #-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-, #-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-, #-(CH2)3-O-(CH2)3-O-(CH2)2-, #-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-, #-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-, #-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-, #-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-, #-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-, #-CH2-O-(CH2)2-O-CH2-, #-(CH2)2-O-(CH2)2-O-CH2-, #-(CH2)2-(O(CH2)2)2-O-(CH2)3-, #-(CH2)2-(O(CH2)2)3-O-(CH2)3-, #-(CH2)2-(O(CH2)2)4-O-(CH2)3-, #-(CH2)5-(O(CH2)2)2-O-(CH2)5-, #-(CH2)5-(O(CH2)2)2-O-(CH2)6-, #-(CH2)i-N(Rg)-(CH2)i-, #-(CH2)i-N(Rg)-(CH2)2-, #-(CH2)i-N(Rg)-(CH2)3-, #-(CH2)i-N(Rg)-(CH2)4-, #-(CH2)i-N(Rg)-(CH2)5-, #-(CH2)i-N(Rg)-(CH2)6-, #-(CH2)i-N(Rg)-(CH2)7-, #-(CH2)i-N(Rg)-(CH2)8-, #-(CH2)i-N(Rg)-(CH2)9-, #-(CH2)i-N(Rg)-(CH2)io-, #-(CH2)2-N(Rg)-(CH2)i-, #-(CH2)2-N(Rg)-(CH2)2-, #-(CH2)2-N(Rg)-(CH2)3-, #-(CH2)2-N(Rg)-(CH2)4-, #-(CH2)2-N(Rg)-(CH2)5-, #-(CH2)2-N(Rg)-(CH2)6-, #-(CH2)2-N(Rg)-(CH2)7-, #-(CH2)2-N(Rg)-(CH2)8-, #-(CH2)2-N(Rg)-(CH2)9-, #-(CH2)2-N(Rg)-(CH2)io-, #-(CH2)2-N(Rg)-(CH2)ii-, #-(CH2)2-N(Rg)-(CH2)i2-, #-(CH2)3-N(Rg)-(CH2)i-, #-(CH2)3-N(Rg)-(CH2)2-, #-(CH2)3-N(Rg)-(CH2)3-, #-(CH2)4-N(Rg)-(CH2)i-, #-(CH2)4-N(Rg)-(CH2)2-, #-(CH2)4-N(Rg)-(CH2)3-, #-(CH2)4-N(Rg)-(CH2)4-, #-(CH2)5-N(Rg)-(CH2)i-, #-(CH2)5-N(Rg)-(CH2)2-, #-(CH2)5-N(Rg)-(CH2)3-, #-(CH2)5-N(Rg)-(CH2)4-, #-(CH2)5-N(Rg)-(CH2)5-, #-(CH2)6-N(Rg)-(CH2)i-, #-(CH2)6-N(Rg)-(CH2)2-, #-(CH2)6-N(Rg)-(CH2)3-, #-(CH2)7-N(Rg)-(CH2)i-, #-(CH2)7-N(Rg)-(CH2)2-, #-(CH2)7-N(Rg)-(CH2)3-, #-(CH2)8-N(Rg)-(CH2)i-, #-(CH2)8-N(Rg)-(CH2)2-, #-(CH2)8-N(Rg)-(CH2)3-, #-CH(CH3)-N(Rg)-(CH2)i-, #-CH(CH3)-N(Rg)-(CH2)2-, #-CH(CH3)-N(Rg)-(CH2)3-, #-CH(CH3)-N(Rg)-(CH2)4-, #-CH(CH3)-N(Rg)-(CH2)5-, #-CH(CH3)-N(Rg)-(CH2)6-, #-CH(CH3)-N(Rg)-(CH2)7-, #-CH(CH3)-N(Rg)-(CH2)8-, #-CH(CH3)-N(Rg)-(CH2)9-, #-CH(CH3)-N(Rg)-(CH2)io-> #-CH2C(O)NHCH2-, #-(CH2)2C(O)NH(CH2)2-,       #-(CH2)2C(O)NH(CH2)3-,       #-(CH2)2C(O)NH(CH2)4-,       #-(CH2)2C(O)NH(CH2)5-,       #-(CH2)3C(O)NH(CH2)3-,       #-(CH2)3C(O)NH(CH2)4-,       #-(CH2)4C(O)NH(CH2)4-,       #-(CH2)5C(O)NH(CH2)5-,       #-(CH2)6C(O)NH(CH2)7-,       #-(CH2)6C(O)NH(CH2)6-,      #-(CH2)7C(O)NH(CH2)7-,      #-(CH2)8C(O)NH(CH2)8,      u-(CH2)9C(O)NH(CH2)9-, #-(CH2)ioC(0)NH(CH2)io-, #-(CH2)2C(O)NH(CH2)2-O-(CH2)2-, #-CH2NHC(O)CH2-, #-(CH2)2NHC(O)(CH2)2-, #-(CH2)2NHC(O)(CH2)3-, #-(CH2)2NHC(O)(CH2)4-, #-(CH2)2NHC(O)(CH2)5-,       #-(CH2)3NHC(O)(CH2)3-,       #-(CH2)3NHC(O)(CH2)4-,       #-(CH2)4NHC(O)(CH2)4-,       #-(CH2)5NHC(O)(CH2)5-,       #-(CH2)6NHC(O)(CH2)7-,       #-(CH2)6NHC(O)(CH2)6-, #-(CH2)7NHC(O)(CH2)7-, #-(CH2)8NHC(O)(CH2)8, #-(CH2)9NHC(O)(CH2)9-, #-(CH2)ioNHC(0)(CH2)io-, #-(CH2)4NHC(O)(CH2)8-, #-(CH2)2NHC(O)(CH2)2-O-(CH2)2-, #-(CH2)4NHC(O)CH2-, #-CH2-piperidinylene-CH2-, #-CH2-piperidinylene-(CH2)2-, #-CH2-piperidinylene-(CH2)3-, #-CH2-piperidinylene-(CH2)4-, #-CH2-piperidinylene-(CH2)5-, #-CH2-piperidinylene-(CH2)6-, #-CH2-piperidinylene-(CH2)7-, #-CH2-piperidinylene-(CH2)8-, #-(CH2)2-piperidinylene-(CH2)i-, #-(CH2)2-piperidinylene-(CH2)2-, #-(CH2)2-piperidinylene-(CH2)3-, #-(CH2)2-piperidinylene-(CH2)4-, #-(CH2)2-piperidinylene-(CH2)5-, #-(CH2)2-piperidinylene-(CH2)6-, #-(CH2)2-piperidinylene-(CH2)7-, #-(CH2)2-piperidinylene-(CH2)8-, #-(CH2)3-piperidinylene-CH2-, #-(CH2)3-piperidinylene-(CH2)2-, #-(CH2)3-piperidinylene-(CH2)3-, #-(CH2)3-piperidinylene-(CH2)4-, #-(CH2)3-piperidinylene-(CH2)5-, #-(CH2)3-piperidinylene-(CH2)6-, #-(CH2)3-piperidinylene-(CH2)7-, #-(CH2)3-piperidinylene-(CH2)8-, #-(CH2)4-piperidinylene-CH2-, #-(CH2)4-piperidinylene-(CH2)2-, #-(CH2)4-piperidinylene-(CH2)3-, #-(CH2)4-piperidinylene-(CH2)4-, #-(CH2)4-piperidinylene-(CH2)5-, #-(CH2)4-piperidinylene-(CH2)6-, #-(CH2)4-piperidinylene-(CH2)7-, #-(CH2)4-piperidinylene-(CH2)8-, #-(CH2)s-piperidinylene-(CH2)i-, #-(CH2)5-piperidinylene-(CH2)2-, #-(CH2)5-piperidinylene-(CH2)3-, #-(CH2)s-piperidinylene-(CH2)4-, #-(CH2)5-piperidinylene-(CH2)5-, #-(CH2)5-piperidinylene-(CH2)6-, #-(CH2)s-piperidinylene-(CH2)7-, #-(CH2)5-piperidinylene-(CH2)8-, #-(CH2)6-piperidinylene-(CH2)i-, #-(CH2)6-piperidinylene-(CH2)2-, #-(CH2)6-piperidinylene-(CH2)3-, #-(CH2)6-piperidinylene-(CH2)4-, #-(CH2)6-piperidinylene-(CH2)5-, #-(CH2)6-piperidinylene-(CH2)6-, #-(CH2)6-piperidinylene-(CH2)7-, #-(CH2)6-piperidinylene-(CH2)8-, #-(CH2)7-piperidinylene-(CH2)i-, #-(CH2)7-piperidinylene-(CH2)2-, #-(CH2)7-piperidinylene-(CH2)3-, #-(CH2)7-piperidinylene-(CH2)4-, #-(CH2)7-piperidinylene-(CH2)8-, #-(CH2)s-piperidinylene-CH2-, #-(CH2)8-piperidinylene-(CH2)2-, #-(CH2)8-piperidinylene-(CH2)3-, #-(CH2)s-piperidinylene-(CH2)4-, #-(CH2)8-piperidinylene-(CH2)5-, #-(CH2)8-piperidinylene-(CH2)6-, #-(CH2)s-piperidinylene-(CH2)7-, #-(CH2)8-piperidinylene-(CH2)8-, #-CH2-N(Rg)-CH2-piperidinylene-CH2-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)2-, #-CH2-N(Rg)-CH2-piperidinylene-(C^^ #-CH2-N(Rg)-CH2-piperidinylene-(CH2)4-, #-CH2-N(Rg)-CH2-piperidinylene-(CH2)5-,piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)4-, piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)4-, piperidinylene-(CH2)6-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)8-, piperidinylene-(CH2)2-, piperidinylene-(CH2)4-, piperidinylene-(CH2)6-,#-CH2-N(Rg)-CH2-piperidinylene-(CH2)7-,#-CH2-N(Rg)-(CH2)2-piperidinylene-CH2-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)3-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)5-,#-CH2-N(Rg)-(CH2)2-piperidinylene-(CH2)7-,#-(CH2)2-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)5-,#-(CH2)2-N(Rg)-CH2-piperidinylene-(CH2)7-,#-(CH2)3-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)3-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)4-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)4-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)5-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)6-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)7-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)8-N(Rg)-CH2-piperidinylene-CH2-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)3-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)5-,#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)7-,#-CH2-N(Rg)-CH2-#-CH2-N(Rg)-CH2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-CH2-N(Rg)-(CH2)2-#-(CH2)2-N(Rg)-CH2-#-(CH2)2-N(Rg)-CH2-#-(CH2)2-N(Rg)-CH2-#-(CH2)2-N(Rg)-CH2-#-(CH2)3-N(Rg)-CH2-#-(CH2)3-N(Rg)-CH2-#-(CH2)4-N(Rg)-CH2-#-(CH2)4-N(Rg)-CH2-#-(CH2)5-N(Rg)-CH2-#-(CH2)6-N(Rg)-CH2-#-(CH2)7-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-#-(CH2)8-N(Rg)-CH2-piperidinylene-(CH2)8-,piperazinylene-(CH2)3-,piperazinylene-(CH2)6-,#-CH2-piperazinylene-CH2-,#-CH2-piperazinylene-(CH2)4-,#-CH2-piperazinylene-(CH2)7-,#-CH2-piperazinylene-(CH2)2-,#-CH2-piperazinylene-(CH2)5-,#-CH2-piperazinylene-(CH2)8-,#-ch2-#-ch2-#-(CH2)2-piperazinylene-(CH2)i-, #-(CH2)2-piperazinylene-(CH2)2-, #-(CH2)2-piperazinylene-(CH2)3-, #-(CH2)2-piperazinylene-(CH2)4-, #-(CH2)2-piperazinylene-(CH2)s-, #-(CH2)2-piperazinylene-(CH2)6-, #-(CH2)2-piperazinylene-(CH2)7-, #-(CH2)2-piperazinylene-(CH2)s-, #-(CH2)3-piperazinylene-CH2-, #-(CH2)3-piperazinylene-(CH2)2-, #-(CH2)3-piperazinylene-(CH2)3-, #-(CH2)3-piperazinylene-(CH2)4-, #-(CH2)3-piperazinylene-(CH2)5-, #-(CH2)3-piperazinylene-(CH2)6-, #-(CH2)3-piperazinylene-(CH2)7-, #-(CH2)3-piperazinylene-(CH2)8-, #-(CH2)4-piperazinylene-CH2-, #-(CH2)4-piperazinylene-(CH2)2-, #-(CH2)4-piperazinylene-(CH2)3-, #-(CH2)4-piperazinylene-(CH2)4-, #-(CH2)4-piperazinylene-(CH2)s-, #-(CH2)4-piperazinylene-(CH2)6-, #-(CH2)4-piperazinylene-(CH2)7-, #-(CH2)4-piperazinylene-(CH2)s-, #-(CH2)5-piperazinylene-(CH2)i-, #-(CH2)s-piperazinylene-(CH2)2-, #-(CH2)s-piperazinylene-(CH2)3-, #-(CH2)5-piperazinylene-(CH2)4-, #-(CH2)5-piperazinylene-(CH2)s-, #-(CH2)s-piperazinylene-(CH2)6-, #-(CH2)5-piperazinylene-(CH2)7-, #-(CH2)s-piperazinylene-(CH2)8-, #-(CH2)6-piperazinylene-(CH2)i-, #-(CH2)6-piperazinylene-(CH2)2-, #-(CH2)6-piperazinylene-(CH2)3-, #-(CH2)6-piperazinylene-(CH2)4-, #-(CH2)6-piperazinylene-(CH2)5-, #-(CH2)6-piperazinylene-(CH2)6-, #-(CH2)6-piperazinylene-(CH2)7-, #-(CH2)6-piperazinylene-(CH2)8-, #-(CH2)7-piperazinylene-(CH2)i-, #-(CH2)7-piperazinylene-(CH2)2-, #-(CH2)7-piperazinylene-(CH2)3-, #-(CH2)7-piperazinylene-(CH2)4-, #-(CH2)7-piperazinylene-(CH2)s-, #-(CH2)8-piperazinylene-CH2-, #-(CH2)8-piperazinylene-(CH2)2-, #-(CH2)8-piperazinylene-(CH2)3-, #-(CH2)8-piperazinylene-(CH2)4-, #-(CH2)8-piperazinylene-(CH2)s-, #-(CH2)8-piperazinylene-(CH2)6-, #-(CH2)8-piperazinylene-(CH2)7-, or #-(CH2)8-piperazinylene-(CH2)8-;wherein the piperidinylene and the piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;each Rg independently represent H or C1-6 alkyl;symbol # indicates the point of attachment to U2; andnl, n2, n3, n4, ml, m2, and m3 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

35. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 20-31, wherein -W^LIN-L^-Rc-Ui- represents the following groups: Uiy      'WD DFwherein the groups are optionally substituted with one or more substituents selected from the groupconsisting of deuterium, halogen, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, or any combination thereof.

36. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, which is also of Formula(III-l), Formula (III-2), Formula (III-3), Formula (III-4), Formula (III-5), Formula (III-6), Formula (III-7), Formula (III-8), Formula (III-9), Formula (III-10), Formula (III-ll), Formula (III-12), Formula (III-13), Formula (III-14), Formula (III-15), Formula (III-16), Formula (III-17), Formula(III-18), Formula (III-19), Formula (III-20), Formula (III-21), Formula (III-22), Formula (III-23) orFormula (III-24):Formula (111-1)Formula (HI-2)(91-111) Binwjod(Skill) B|niwod(Eklll) Biniuioj(frklll) e|nwjod(8-Hl) einwjoj(Z-lll) einwjod(9-IH) einwjod                                                                              (g-lll) Biniujodpi5(R42)oFormula (111-18)Formula (111-17)Formula (111-19)Formula (111-21)Formula (HI-20)Formula (HI-23)                            and                              Formula (HI-24)wherein A, Rb R2, R3, R4, (Rb)n, Ui,U2, Rc, LIN, W1, R1, (R2)pb (R3)p2, (R5)p3, (R6)p4, (R7)p5, R8, R9, R10, (Rn)p7, ring A, ring B, ring C, Xb X2, R14, R15, R16, X3, X4, X5, X6, R18, R19, R20, R25, R26, R27, (R28)p8, R29, X7, X8, X9, (R32)P9, R33, R34, (R36)P1O, (R37)Pib (R38)Pi2, (R39)P13, (R40)pi4, R41, (R42)P15, (R43)pi6, (R44)Pi7, R45, R46, R47, R48, (R49)pi8, R50, and R51 are as defined in claim 22.

37. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, which is selected from:N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((6-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)pyridazine-3 -carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((3 -(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)pyridazine-3 -carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((8-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((3 -(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((( 1S ,4S)-5-(2-(2,6-dioxopiperidin-3 -yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((( 1 R,4R)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((5-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methy l)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methy l)piperidin-l-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((3 -(2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((5-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -y 1)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -y 1)-6-fluoro-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -y 1)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-6,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-4,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((((3R)-1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperi din-1-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-((((3 S)-1 -(2-(2,6-di oxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperi din-1-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexy 1)-6-(4-(((3 S)-3-((2-(2,6-di oxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(((3R)-3 -((2-(2,6-dioxopiperi din-3 -yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;iV-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((l-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide;iV-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((l-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide;iV-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((l-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide;iV-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((l-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)nicotinamide;N-((lr,3S)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(((lS,4S)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3R)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(((lR,4R)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-6?8)niethyl)piperidin-l-yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-l-yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((6-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-t / s) me th y I) p i p e r i d i n -1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-t / s) me th y 1) p i p e r i d i n -1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-t / s) me th y 1) p i p e r i d i n -1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3R)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((((3R)-l-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)nicotinamide;N-((lr,3S)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((((3S)-l-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(((3R)-3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)nicotinamide;iV-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;iV-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;iV-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)pyridazine-3-carboxamide;iV-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l, 3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)-3-fluorocyclohexyl)methyl)piperazin-1 -yl)-2-(2,6-di oxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(3 -((4-(4-amino-3 -(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(3-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,6-diazabicyclo[3.

1. l]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(6-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)cyclohexyl)methy 1)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din- l-yl)-3-fluorocyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(3 -((4-(4-amino-3 -(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(3-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((lS,4S)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((lS,4S)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-((lR,4R)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((lR,4R)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1 -yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methy 1)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)-3-fluorocyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-3,5-dimethylpiperazin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-( l-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(1 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluorocyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din- l-yl)-3-fluorocyclohexyl)methyl)piperazin-1 -yl)-2-(2,6-di oxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -di one;5-(3 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperi din-3 -yl)-6-fluoroisoindoline-1,3 -dione;5-(3-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(6-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methy 1)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperi din-3 -yl)-6-fluoroisoindoline-1,3 -dione;5-(6-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din- l-yl)-3-fluorocyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(3 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((lS,4S)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((lS,4S)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((lR,4R)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((lR,4R)-5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1 -yl)-3-fluorocyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methy 1)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)-3-fluorocyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methy 1)-3,5-dimethylpiperazin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)-3-fluorocyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-( l-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluorocyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(4-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-c?8)-2-(2,6-dioxopiperidin-3-yl)-4,7 -difluoroisoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;6-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;6-(4-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -y 1) - 3 -fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;5-(4-((4-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-d]pyrimi din-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-^)-2-(2,6-dioxopiperidin-3-yl)-4,6,7 -trifluoroisoindoline-1,3-dione;5-(4-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-((R)-3-(((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)amino)piperidin-1 -yl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3 -dione;5-((3R)-3-(((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)amino)piperidin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-((S)-3-(((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)cyclohexyl)methyl)amino)piperidin-1 -yl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3 -dione;5-((3S)-3-(((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)amino)piperidin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(((S)-1 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo[3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((3 S)-1 -((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluorocyclohexyl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((R)-1 -((4-(4-amino-3-(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)cyclohexyl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((3R)-l-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluorocyclohexyl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methy Ibenzy 1)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperi din- l-yl)phenyl)-l H-indazol-3-yl)-2-methy Ibenzy 1)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-(((lS,4S)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-(((lR,4R)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-6?8)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -y 1)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methy Ibenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-(((lS,4S)-5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-(((lR,4R)-5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-l,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)phenyl)-lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((((3R)-l-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((((3S)-1-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-(((3 S)-3-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-(((3R)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;2-(2,6-dioxopiperi din-3 -y 1)-5-(4-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-1 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methy l)piperidin-4-yl)methyl)piperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(3 -((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3. l.l]heptan-6-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methy 1)-3,6-diazabicyclo[3.1.1]heptan-6-yl)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(6-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3. l.l]heptan-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(6-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methy 1)-3,6-diazabicyclo[3.1.1]heptan-3-yl)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(3 -((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.

2. l]octan-8-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.

2. l]octan-8-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(8-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperi din-3-y 1)-5-(8-(( 1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-((lS,4S)-5-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methy 1)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-((lS,4S)-5-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-y 1)-5-(( 1 R,4R)-5-(( 1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methy 1)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-fluoro-6-(( 1 R,4R)-5-(( 1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(5-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methy l)piperidin-4-yl)methy 1)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(4-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-5-(4-((l-((6-((5-fhioro-4-(4-fhioro-l-isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-5-(4-((l-((6-((5-fhioro-4-(4-fhioro-l-isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-4,5,7-trifluoro-6-(4-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(4-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-((6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methy 1)-3,5-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(4-(( 1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-( 1-((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperi din-3-yl)-5-fluoro-6-( 1-((1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1 H-benzo [d] imi dazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -yl)-5-((R)-3 -(((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methy l)piperidin-4-yl)methyl)amino)piperidin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -yl)-5-((S)-3 -(((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3-yl)methy l)piperidin-4-yl)methyl)amino)piperidin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -yl)-5-(((R)-1-((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)piperidin-3 -yl)amino)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3 -yl)-5-(((S)-1-((1 -((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperidin-4-yl)methyl)piperidin-3 -yl)amino)isoindoline- 1,3-dione;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5 -yl)piperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo [2,3 -d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((( 1 R,4R)-5-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((lS,4S)-5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((lS,4S)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((lR,4R)-5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5 -yl)piperazin-1 -yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-4,6,7-trifluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5 -y 1)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5 -yl)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo [2,3 -d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((((3R)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((((3 S)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((3R)-3 -((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-l,3-dione;6-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -di one;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)-4,6-difluoroisoindoline-1,3 -dione;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)-4,7-difluoroisoindoline-1,3 -dione;6-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3 -yl)-4,5-difluoroisoindoline-1,3 -dione;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-l,3-dione;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(4-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(1 -((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(1 -((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3-(((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-((S)-3-(((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(((S)-l-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(((R)-l-((l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-1 -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(( 1-(4-((5-chloro-4-((2-(dimethy Iphosphory l)pheny l)amino)pyrimi din-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(4-((5-chloro-4-((2-(dimethy Iphosphory l)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(3-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(6-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(6-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(3-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(3-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(8-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(8-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(5-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(5-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3 -di one;6-(4-((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -di one;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((R)-3 -(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((S)-3-(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-1 -((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((R)-1-((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-me thy lphenyl)piperidin-4-yl)methy 1)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-me thy lphenyl)piperidin-4-yl)methy 1)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(8-((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;6-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;5-(4-((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-(( l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(1-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3 -(((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-((S)-3-(((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(((S)-1 -((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(((R)-1-((1 -(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl)methyl)piperi din-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1 ]octan-3-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1 ]octan-8-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperi din-1-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b] carbazole-3-carbonitrile;8-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-l-yl)methyl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;5-(3-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(6-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;5-(6-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(3-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(3-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(8-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(5-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;6-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-c?8)-2-(2,6-dioxopiperidin-3-yl)-4,7 -difluoroisoindoline-1,3 -dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-c?8)-2-(2,6-dioxopiperidin-3-yl)-4,6,7 -trifluoroisoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(l-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(l-((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3-(((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyri din-3-yl)-lH-pyrazol-1 -yl)cyclohexyl)methyl)amino)piperidin-l -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((S)-3-(((4-(4-(6-amino-5-((R)-l-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyrazol-1 -yl)cyclohexyl)methyl)amino)piperidin-l -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-1 -((4-(4-(6-amino-5-((R)-1 -(2,6-dichloro-3 -fluorophenyl)ethoxy)pyridin-3 -yl)-1H-pyrazol-1 -yl)cyclohexyl)methyl)piperidin-3 -yl)amino)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;5-(((R)-l-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyri din-3-yl)-lH-pyrazol-1 -yl)cyclohexyl)methyl)piperidin-3 -yl)amino)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-l -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((6-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3. l.l]heptan-6-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-13-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((((3R)-1-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((((3S)-1-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-(((3R)-3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((3 -(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((3 -(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((3 -(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((3 -(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-tri fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-((((3 R)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3 -(4-((((3 S)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3 -chloro-4-fluorophenyl)amino)-7-(3 -(4-(((3R)-3 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -y 1)-6-fluoroisoindoline-1,3-dione;5-(6-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(6-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(8-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3 -dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3>5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3 -dione;6-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1 -((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(1 -((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)cyclohexyl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-1 -yl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3-dione;5-(4-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(3-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -di one;5-(6-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;5-(6-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -di one;5-(3-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(3-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(8-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(8-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3 -di one;5-(5-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(5-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-(( 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3 -di one;6-(4-(( 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3 -di one;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-6?8)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-(4-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1-((1 -(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(1-((1 -(3 -((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3-(((l-(3-((4-((3-chi oro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((S)-3-(((l-(3-((4-((3-chi oro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-1-(( 1-(3-((4-((3-chi oro-4-fluoropheny l)amino)-7-methoxy quinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((R)-1-(( 1-(3-((4-((3-chi oro-4-fluoropheny l)amino)-7-methoxy quinazolin-6-yl)oxy)propyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-y l)piperazin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methyl)piperi din- l-yl)ethy l)(methy l)amino)-4-methoxy-5-((4-( 1-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperi din- l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-y l)piperazin-1 -yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1,3 -dioxoisoindolin-5-y l)piperazin-1 -yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1,3 -dioxoisoindolin-5-y l)piperazin-1 -yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3»5,5,6,6-<78)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-tri fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-y l)piperidin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((((3R)-1-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-((((3 S)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-3 -yl)amino)methyl)piperidin-l-yl)ethyl)(methyl)amino)-4-methoxy-5-((4-(l -methyl- lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-(((3 S)-3-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)ammo)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(4-(((3R)-3 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-l-yl)ethyl)(methyl)ammo)-4-methoxy-5-((4-(l-methyl-lH-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methy l)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3. l.l]heptan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((6-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3. l.l]heptan-6-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((3 -(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-c?8)niethyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-4,6,7-trifluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((((3R)-1 -(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-3 -yl)amino)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-((((3S)-1-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(4-(((3R)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-l-yl)methyl)piperidin-1 -yl)but-2-enamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3-yl)-l,3-dioxoisoindolin-5-yl)piperazin-l-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((6-(2-(2,6-dioxopiperi din-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((8-(2-(2,6-dioxopiperi din-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo [3.2.1 ] octan-8-yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo [3.2.1 ] octan-8-yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo [2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo [2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)pyridazin-3 -yl)-1 -oxoisoindolin-2-yl)-2-(5 -fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-4,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<7s)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-6,7-difluoro-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3-yl)-1,3-dioxoisoindolin-5-yl)-3,5-dimethy lpiperazin-1-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-l-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3-yl)-l,3-dioxoisoindolin-5-yl)piperi din-1-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((4-(2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((((3R)-1-(2-(2,6-dioxopiperi din-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((((3S)-l-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-l-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-(((3R)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-l-yl)methyl)piperidin-1 -yl)pyridazin-3-yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(2,6-dioxopiperidin-3-yl)-5-(4-(( l-(((R,E)-l ',26,7-lrimelhyl-3-oxo-52,53-dihydro-l          I-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-1 -yl)isoindoline-1,3-di one;2-(2,6-dioxopiperidin-3-yl)-5-(3-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-(6-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(6-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-(3-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.

2. l]octan-8-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(8-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1 H,5' H-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(8-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(5-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1 H,5' H-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(5-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1 H,5' H-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1 H,5' H-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-5-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-5-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-6-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1          -oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,7-trifluoro-6-(4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-PH,5 ^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-rYspsoindoline-1,3-dione;5-(2,6-dimethyl-4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-ll-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(2,6-dimethyl-4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-ll-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione;5-(3,5-dimethyl-4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-ll-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(3,5-dimethyl-4-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-ll-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperazin-1 -yl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-( 1 -((1 -(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-fluoro-6-(l-((1 -(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((R)-3-(((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)amino)piperidin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((S)-3-(((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-1 l-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)amino)piperidin-l-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((S)-l-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-1 l-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperidin-4-yl)methyl)piperidin-3-yl)amino)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((R)-l-((l-(((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methy l)piperidin-4-yl)methyl)piperi din-3-yl)amino)isoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(3-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(3-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(6-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(6-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(5-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(5-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(4-(( 1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6-difluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,7-difluoroisoindoline-1,3-dione;6-(4-(( 1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)-2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-1 -yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(4-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-1 -yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(1-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione;5-(1-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-((R)-3 -(((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((S)-3-(((1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)amino)piperidin-l-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-1 -((1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((R)-1-((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-3-yl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methyl)piperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(3 -((1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methy 1)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3. l.l]heptan-6-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(6-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methy 1)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(6-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,6-diazabicyclo [3. l.l]heptan-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(3 -((1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(3-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.

2. l]octan-8-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(8-(( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(8-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,8-diazabicyclo [3.2.1 ] octan-3 -yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(5-(( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-(5-(( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(5-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-6-(4-(( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5-difluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4,5,7-trifluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-l-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-2,6-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)-3,5-dimethylpiperazin-l-yl)isoindoline-1,3 -dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)methy 1)-3,5-dimethylpiperazin-1 -yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-( 1-((1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(l-((1-(1-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)isoindoline-1,3 -dione;N-(tert-butyl)-3 -((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3-yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((6-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3. l.l]heptan-3-yl)methyl)piperi din-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((3 -(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3. l.l]heptan-6-yl)methyl)piperi din-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((3 -(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((5-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((5-(2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1,3 -dioxoisoindolin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6,7-difluoro-l,3-dioxoisoindolin-5-yl)piperazin-1 -yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-4,6,7-trifluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl-2,2,3,3,5,5,6,6-<78)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,5-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-2,6-dimethylpiperazin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperidin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((((3R)-1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-((((3 S)-1 -(2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperidin-3-yl)amino)methyl)piperidin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-(((3S)-3-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3 -((2-((4-(2-(4-(((3R)-3 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)amino)piperidin-1 -yl)methyl)piperidin-1 -yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;4-(4-((4-(2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)piperazin-1 -yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)piperazin-l-yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)piperidin-1 -yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((3-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindolin-5-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((8-(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)-3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]p...

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