Control of total afucosylated glycoforms of antibodies produced in cell culture
AU2023285706B2Pending Publication Date: 2026-07-23AMGEN INC
Patent Information
- Application Number
- AU2023285706
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2023-12-18
- Publication Date
- 2026-07-23
- Estimated Expiration
- 2038-03-14
Smart Images
Figure 00000049_0000 
Figure 00000050_0000 
Figure 00000051_0000
Abstract
Provided herein are methods of modulating the levels of total afucosylated (TAF) glycoforms of a recombinant glycosylated protein produced by glycosylation-competent cells in a cell culture. In exemplary embodiments, the methods comprise maintaining the cell culture at an initial set point pH for an initial cell culture period. Related compositions comprising glycosylated proteins and TAF glycoforms thereof are also provided herein. 20 23 28 57 06 18 D ec 2 02 3 A B S T R A C T 2 0 2 3 2 8 5 7 0 6 1 8 D e c 2 0 2 3
Need to check novelty before this filing date? Find Prior Art
Citation Information
Patent Citations
Method for obtaining glycoprotein composition with increased afucosylation content
WO2013114164A1
Process of obtaining glycoform composition
WO2013114167A1
Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation
WO2015128795A1