New composition and method for green manufacture of robust, stable and monodisperse drug carriers using the improved Mozafari method at ambient temperature.

Abstract

The embodiments herein provide a new formulation and method for robust manufacturing of various stable micro- and nano-carrier systems for the encapsulation of bioactive agents, pharmaceuticals, minerals and other compounds. According to one embodiment herein, a fine- tuned composition of pharmaceutical ingredients, excipients, solvents, co-solvents, antioxidants, lipids, helper-lipids, sterols and alike, along with one or more active compound(s) is introduced. The combination of the mentioned ingredients is selected such that the combined phase transition temperature of the carrier system is substantially below room temperature. According to another embodiment presented here an easily scalable method is introduced for producing a microcarrier or nanocarrier complex of a pharmaceutical or biological or food or other molecules and compounds disposed within a micro- or nano-carrier system. Whereas the currently available green-procedure for large-scale manufacture of carrier complexes / encapsulation systems known as Mozafari method has the limitation of using moderately high temperatures, the improved Mozafari method can be practiced at any room temperature (even below 20°C). The method, hence, can be applied to all known types of bioactive compounds, drug molecules, vaccine candidates, and diagnostic agents. Using this method, micro- or nano- carrier complexes of the bioactive ingredients with enhanced stability and narrow size distribution and ideal polydispersity index are obtained on large, industrial scales. 20 25 20 16 66 07 M ar 2 02 5 M a r 2 0 2 5 2 0 2 5 2 0 1 6 6 6 0 7 I n v e n t o r s :