Methods for the prophylaxis and treatment of obesity and related conditions and disorders

AU2025211528A1Pending Publication Date: 2026-09-10LLOYD TRAN
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Patent Information

Application Number
AU2025211528
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-01-12
Filing Date
2025-01-22
Publication Date
2026-09-10

AI Technical Summary

Technical Problem

Current treatments for obesity and metabolic disorders, such as obesity-related diabetes, often result in modest weight loss that is difficult to maintain, and there is a need for more effective pharmaceutical interventions that can achieve significant and sustained weight loss while improving metabolic health markers.

Method used

The use of cyclic Prolyl Glycine (cPG) compounds, optionally combined with GLP-1 agonists like tirzepatide, semaglutide, or liraglutide, administered orally or subcutaneously, to regulate IGF-1 and GLP-1 signaling pathways, reducing food intake, inducing satiety, and improving glycemic control.

Benefits of technology

The combination therapy with cPG and GLP-1 agonists achieves significant and sustained weight loss, improves metabolic health markers, and reduces plasma and liver triglycerides, demonstrating potential synergy in treating obesity and diabetes.

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Abstract

The present invention recognizes that, there is a need for the prophylaxis or treatment of obesity, glycemic control, and other metabolic disorders. A first aspect of the present invention generally relates to methods of prophylaxis or treatment of obesity, glycemic control, and other metabolic disorders, using various pharmaceutical compositions. A second aspect of the present invention generally relates to mono-therapy or combination therapy used for the prophylaxis or treatment of obesity, glycemic controh other metabolic disorders, and combinations thereof
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