Compositions and methods for pulmonary surfactant-biomimetic nanoparticles

Abstract

Abstract Compositions and methods comprising pulmonary surfactant (PS)-biomimetic nanoparticles are disclosed. In particular, the disclosure relates to a composition comprising a negatively charged nanoparticle having an average size of 200 to 400 nm and comprising a plurality of pulmonary surfactant-biomimetic molecules, and one or more cargo molecules enveloped by the nanoparticle, wherein the cargo molecule has a molecular weight of up to 1200 Da. Abstract A B C 40x 4.0 10 5 PBS ** wo 2021 / 071823 Perth Body weight change (%) 4 4 5 2.0 Perth+PS-GAMP 0 0.0 IgG titer Log10 3 = -5 2 -2.0 -10 1 0 2 4 6 8 0 2 4 6 8 SUBSTITUTE SHEET (RULE 26) Days post immunization Days post immunization PBS Perth GAMP D E Perth Michigan 36 / 36 640 ** 320 HAI titer 80 160 80 40 40 20 20 PBS Perth+PS. Perth .GAMP PBS Perth+PS. Perth .GAMP PCT / US2020 / 054377 FIGS. 37A-37E 20 26 20 81 21 27 J ul 2 02 6 2 0 2 6 2 0 8 1 2 1 2 7 J u l 2 0 2 6 ABC 5 T e m p e r a t u r e C h a n g e ( ° C ) 2 0 1 1 / 0 7 1 8 2 3 O M 4 5 P e r t h + P S - G A M P 03 2 1 0246802468 S U B S T I T U T E S H E E T ( R U L E 2 6 ) Days post immunization Days post immunization P B S P e r t h DE 3 6 / 3 6 6 4 0 3 2 0 H A I t i t e r 1 6 0 H A I t i t e r P B S P e r t h P C T / U S 2 0 2 0 / 0 5 4 3 7 7 F I G S . 3 7 A - 3 7 E

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