Serpin fusion polypeptides and methods of use thereof

Abstract

1006806752 Abstract This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. Abstract 1006806752 20 26 22 02 36 20 A ug 2 02 6 2 0 2 6 2 2 0 2 3 6 2 0 2 0 2 6 A u g 1 0 0 6 8 0 6 7 5 2

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