Cleavable activators of CXCR3 and methods of use

AU2026220274A1Pending Publication Date: 2026-09-10UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
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Patent Information

Application Number
AU2026220274
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Filing Date
2026-08-21
Publication Date
2026-09-10

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Abstract

Abstract Recombinant C-X-C motif chemokine ligand (CXCL) peptides modified to introduce a cleavage site for a protease, such as a protease activated during an inflammatory response, are described. The CXCL peptides have the capacity to activate CXCR3 until being cleaved by the protease. Proteolytic cleavage of the CXCL peptide minimizes the pro-inflammatory response and inhibits the development of fibrosis. Abstract
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