Methods of preparing chiral benzodiazepinone derivatives

Abstract

IZ H O N (R²) NH2 n N (R¹) n1 wherein: CH H O N NH N F CH HN O NH N X F 20 26 22 31 99 25 A ug 2 02 6 A B S T R A C T 2 0 2 6 2 2 3 1 9 9 2 5 A u g 2 0 2 6 O N H N w h e r e i n : C H H O N H N F C H O N H N X F chloride, acetate, adipate, alginate, ascorbate, aspartate, benzoate, benzenesulfonate, bisulfate, borate, butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, hydroiodide, maleate, 2-hydroxyethanesulfonate, lactate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oxalate, pectinate, persulfate, 3- phenylpropionate, phosphate, picrate, pivalate, propionate, salicylate, succinate, sulfate, sulfonate, tartrate, thiocyanate, toluenesulfonate, or undecanoate salt, or any combination thereof. 20 26 22 31 99 25 A ug 2 02 6 2 0 2 6 2 2 3 1 9 9 2 5 2 0 2 6 A u g t h e r e o f .

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