Improved methods for the acylation of maytansinol
BNRE20250019BUndetermined Publication Date: 2025-08-31IMMUNOGEN INC
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Patent Information
- Application Number
- BNRE20250019
- Authority / Receiving Office
- BN · BN
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2012-09-26
- Filing Date
- 2020-03-18
- Publication Date
- 2025-08-31
- Estimated Expiration
- 2040-03-18
Abstract
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also diselosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.
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