Insecticidal composition, process and method of pest control with etiprole and pyriproxyfen.

Description

1 / 13 Insecticidal composition, process and method for pest control with etiprole and pyriproxyfen. Technical Sector.

[01] This invention discloses an insecticide composed of etiprole and pyriproxyfen in effective quantities as a means of controlling unwanted pests, and is situated in the field of plant preservation products and / or plant parts thereof. State of the Art.

[02] The decline in agricultural production due to the presence of insects is a problem in which science is constantly working to find solutions that aim to help farmers minimize losses and maximize the productive yield of their crops, since the use of insecticides and pesticides is increasingly employed and this has made pests resistant to control, a fact that forces the growth of the demand for conducting trials to improve plant treatment.

[03] One way to contribute to plant treatment is revealed here with the application of an insecticide composed of etiprole and pyriproxyfen in quantities effective for protecting plants, plant propagation materials and their growing environment against pest attack and infestation.

[04] The combined use of two active ingredients with different mechanisms of action reduces the risk of resistance development by pests, as insect populations have less chance of adapting simultaneously to both modes of action. Summary of the Invention.

[05] This invention relates to a compound that aims to control pests and involves the application of effective amounts of insecticide comprising the combination of pyriproxyfen and etiprole in effective quantities to a plant, Petition 870250013436, dated 19 / 02 / 2025, page 5 / 22 2 / 13 plant propagation materials, growing environment, pests or their food source, habitat or growing sites.

[06] As the first active ingredient in this composition, etiprole is an insecticide from the phenylpyrazole group, commonly used in the control of agricultural pests. Etiprole acts as an antagonist of gamma-aminobutyric acid (GABA)-mediated chloride channels in insect nerve cells. It blocks these ion channels, preventing chloride ions from entering the cells. This results in overstimulation of nerve cells, leading to hyperactivity, paralysis, and eventually, the death of the insect. This mode of action directly affects the central nervous system of insects, being effective against a wide range of pests, such as beetles, bedbugs, and other sucking and chewing insects. It is a strategic option for the efficient management of pests, especially in situations where there is resistance or a need to prolong the effectiveness of control.

[07] As the second active ingredient in this composition, pyriproxyfen is a growth regulator insecticide, widely used in the control of agricultural pests and disease vectors, such as mosquitoes and whiteflies. It belongs to the class of juvenile hormone analogues and has characteristics that make it especially effective in integrated pest management. Pyriproxyfen acts as an analogue of juvenile hormone (JH), which is essential for the normal development of insects. It interferes with the life cycle of pests, affecting immature stages such as eggs, larvae, and pupae. It minimizes the use of conventional chemical insecticides and preserves the natural enemies of pests.

[08] This mixture combines the benefits of two distinct mechanisms of action, providing a highly effective pest control strategy by combining two modes Petition 870250013436, dated 19 / 02 / 2025, page 6 / 22 3 / 13 of complementary action. Each compound acts differently on insects, broadening the spectrum of control and providing more consistent and lasting results.

[09] The combination of etiprole and pyriproxyfen offers multiple actions, resulting in effective control over both juvenile and adult forms of pests, thus reducing the chances of re-infestation. While etiprole kills adult insects, pyriproxyfen drastically reduces reproduction by preventing the development of immature forms, controlling future generations. This is especially useful for rapidly multiplying pests such as bed bugs and whiteflies. The residual action of pyriproxyfen, which can continue to act for several weeks, combined with the effectiveness of etiprole, offers long-lasting control, reducing the need for frequent reapplications. The combination can be integrated into integrated pest management programs, allowing for the rational use of insecticides and minimizing the impact on natural enemies and pollinators. Pyriproxyfen, in particular, has less impact on beneficial insects because it targets the immature stages of pests.

[10] This invention also relates to the use of an insecticide composed of etiprole and pyriproxyfen in effective quantities for the control of selected pests from the order Hemiptera, Coleoptera, Lepidoptera and Diptera.

[11] This invention also aims to provide a composition that can be used at lower dosage rates compared to other insecticides and insecticidal compositions, in order to avoid adverse toxicological or environmental effects.

[12] In addition to the aspects already mentioned in the paragraphs above, this invention relates to the use of etiprole and pyriproxyfen in effective quantities as an insecticide for Petition 870250013436, dated 19 / 02 / 2025, page 7 / 22 4 / 13 Protect avocado, pineapple, pumpkin, zucchini, cotton, garlic, peanut, annonaceae, rice, potato, sweet potato, yacon, eggplant, beet, cocoa, coffee, cashew, sugarcane, persimmon, yam, carambola, onion, carrot, shallot, chayote, citrus, cupuaçu, duboisia, pea, bean, fig, tobacco, gerbera, guava, chickpea, guarana, taro, eggplant, lentil, apple, macadamia, papaya, cassava, arracacha, mango, mangaba, passion fruit, gherkin, watermelon, melon, millet, corn, turnip, pastures, cucumber, pepper, bell pepper, okra, kiwi, radish, cabbage, pomegranate, rose, soybean, sorghum, tomato and grape plants, their plant propagation material or their growing environment, from attack or infestation by pests. selected from Bemisia tabaci race B, Thrips palmi, Leucoptera coffeella, Diaphorina citri, Orthezia praelonga, Selenaspidus articulatus, Bemisia tabaci, Frankliniella schultzei, Anthonomus grandis, Oryzophagus oryzae, Hypothenemus hampei, Heterotermes tenuis,Mahanarva fimbriolata, Dichelops melacanthus, Nezara viridula, Piezodorus guildinii, Dalbulus maidis, Euschistus heros and their aggregations.

[13] Pests, and especially insects of the orders Hemiptera, Coleoptera, Lepidoptera, and Diptera, ruin harvested and growing crops, causing large economic losses in the food chain. A major threat in relation to these pests, Nezara viridula, feeds directly on the pods, sucks the grains, and can cause a drop in productivity, a reduction in grain quality, or inject toxins, causing deformities in the plants. With regard to soybeans, this damage can affect up to 30% of productivity and losses of up to 2 billion dollars per harvest. For corn, productivity losses can reach 20% and losses of 900 million dollars. In cotton, this pest can lead to losses of 500 million dollars with a decrease of about 25% in productivity. Pest resistance to insecticides and double insecticide compositions already Petition 870250013436, dated 19 / 02 / 2025, page 8 / 22 The fact that 5 / 13 of existing pests is one of the biggest challenges for large-scale crop farming. It is known in the field that products planted on a large scale, such as soybeans, sugarcane, corn, and cotton, are particularly vulnerable to attack or infestation by insect pests of the orders Hemiptera, Coleoptera, Lepidoptera, and Diptera.

[14] The composition of etiprole and pyriproxyfen produces evident synergistic effects in which the active ingredients do not conflict with each other, which reduces the amount of product needed when applied to crops and lowers the costs of other insecticides.

[15] The mixture is formulated to maximize the synergy between the active ingredients, enhancing pest control and minimizing the chance of pest resistance. The composition of the present invention facilitates application, as ready-mixed blends combine different active ingredients in a single formulation, which reduces the number of applications required and simplifies pest management. This saves time, labor, and reduces operational complexity. With this mixture, there is no need for tank mixing, which reduces errors and provides greater safety in the risks of dosage errors and chemical incompatibilities, ensuring greater product efficacy. In addition, it has multiple control to act on different pests simultaneously, broadening the spectrum of action and providing greater crop protection with a single application.

[16] As used herein, the term “pest resistance” means resistance of pest insects to other insecticides and insecticide mixtures.

[17] As a result, selected plants can be efficiently protected against these pests, in order to avoid a reduction in crop yield. In this particular case, it is an important benefit of the composition, Petition 870250013436, dated 19 / 02 / 2025, page 9 / 22 6 / 13 according to this invention, the composition is also suitable for controlling the pests mentioned above in case of resistance to conventional insecticides or insecticidal compositions.

[18] The combination of etiprole and pyriproxyfen offers a robust solution against difficult-to-control pests, with fast and long-lasting action at different life stages of the insects. In addition, it reduces resistance pressure and improves the efficiency of integrated pest management, resulting in fewer applications and greater sustainability in the field.

[19] The compound of this invention shall hereinafter be referred to as “composition according to the present invention”. Remarks regarding preferred embodiments of the composition according to the present invention shall be understood as the preferred embodiment alone, as well as combinations with each other and in combinations with favorite manipulations in relation to its application and methods which encompass the application of the composition according to the present invention in accordance with what is defined herein and in combination with favorite manipulations with reference to the agrochemical composition stipulated herein.

[20] The composition comprising etiprole and pyriproxyfen as described herein typically includes etiprole and pyriproxyfen subjected to the process in a weight ratio from 1:100 to 100:1 to 1:1.

[21] The mixture can be applied via foliar spraying, seed treatment or to the soil, offering flexibility for different cropping systems and agricultural practices.

[22] The process of applying the composition, according to the present invention, in accordance with its application or method, involves contact with the plant or plant propagation material and contact with its growth environment. The term “growth environment” should be understood as the environment where the plant is growing, whether it be soil or water. Furthermore, the Petition 870250013436, dated 19 / 02 / 2025, page 10 / 22 7 / 13 The method according to the present invention refers to a manipulation to be applied to pests, their food source, habitat or growth environment.

[23] The pests reported are of importance in relation to specific plants. Pests may appear on wild-type plants and plants that have been altered by conventional cultivation, mutagenesis, genetic engineering or one of these fusions. In one embodiment, the term “plant” refers to a plant that has been altered by conventional cultivation, mutagenesis, genetic engineering or one of these fusions.

[24] The means and their applications, according to this invention, may also involve a phase of determining whether pests are resistant to certain insecticides. This phase generally involves collecting a sample to be treated, before the actual application of etiprole and pyriproxyfen or a composition of etiprole and pyriproxyfen and testing using, for example, any appropriate phenotypic, biochemical or molecular biological method to determine resistance / sensitivity. Detailed Description.

[25] The following are appropriate formulations and applications with respect to the present application. These preferred manipulations refer to (i) the composition according to this invention, as well as the application and means that comprise the application of said composition, (ii) the application and means that comprise the application of pyriproxyfen according to this invention, and (iii) the application and means that comprise the application of etiprole according to this invention. Whereas “the composition according to this invention etiprole and pyriproxyfen” is indicated, it should be understood that the manipulations are presented in combination with (i) the composition according to this invention as well as the application and means that comprise the application of said composition, (ii) the application and means that comprise the application of pyriproxyfen. Petition 870250013436, dated 19 / 02 / 2025, page 11 / 22 8 / 13 according to this invention and (iii) application and means encompassing the application of etiprole according to this invention, respectively.

[26] According to this invention, the etiprole and pyriproxyfen composition can be provided in the form of an agrochemical mixture comprising the composition according to this invention, etiprole and pyriproxyfen. An agrochemical mixture comprises an effective insecticidal quantity of a composition according to this invention, etiprole and pyriproxyfen. The expression “effective insecticidal quantity” is set forth below. The compositions according to this invention, etiprole and pyriproxyfen, can be converted into customary types of agrochemical mixtures, such as solutions, emulsions, suspensions, dry powders, powders, pastes, granules and compositions thereof.Examples of mixture types include suspensions (such as SC, OD, FS), emulsifiable concentrates (such as EC), emulsions (such as EW, EO, ES, ME), pastes, dry or wettable powders (such as WP, SP, WS, DP, DS), granules (such as WG, SG, GR, FG, GG, MG) and insecticidal articles (such as LN), as well as gel formulations for the treatment of plant propagation material, such as seeds (such as GF).

[27] Agrochemical mixtures commonly comprise 0.01 to 95%, preferably 0.1 to 90%, and most preferably 0.5 to 75% by weight of active substance. The active substances are employed in a purity of 90% to 100%, preferably 95% to 100%.

[28] Various types of oils, humectants, adjuvants, fertilizers or micronutrients and other pesticides (such as herbicides, insecticides, fungicides, growth regulators and safety agents) may be added to the active substances or to the compositions comprising them as a premix or, where appropriate, not until immediately before use (tank mixing). These agents may be mixed with the Petition 870250013436, dated 19 / 02 / 2025, page 12 / 22 9 / 13 compositions according to the present invention in weight ratios of 1:100 to 100:1 to 1:1.

[29] Additionally, in a manipulation, individual components of the mixture according to this invention or partially premixed components, such as components comprising mixtures according to the present invention, etiprole and pyriproxyfen, can be mixed by the user in a spray tank and additional additives and auxiliaries can be added, if appropriate.

[30] In a further embodiment, individual components of the composition according to the present invention or partially premixed components, such as components comprising mixtures according to the present invention, etiprole and pyriproxyfen, may be applied together (such as after tank mixing) or consecutively.

[31] The mixtures according to the present invention, etiprole and pyriproxyfen, are suitable for use in protecting crops, plants, plant propagation materials, such as seeds, or their growing site against pest attacks or infestation.

[32] The present invention also relates, therefore, to a method of plant protection, comprising contacting crops, plants, plant propagation materials, such as seeds, or their growing location to be protected against insect attack or infestation, with an effective amount as an insecticide of a mixture according to the present invention, etiprole and pyriproxyfen. The mixtures according to the present invention, etiprole and pyriproxyfen, are also suitable for use in combating or controlling pests. The present invention also relates, therefore, to a method of combating or controlling pests, comprising contacting pests, their habitat, growing location, food source, crops, plants, plant propagation materials, such as Petition 870250013436, dated 19 / 02 / 2025, page 13 / 22 10 / 13 seeds, soil, area, material or environment in which insects are developing or may develop, with an effective amount as an insecticide of a mixture according to the present invention, etiprole or pyriproxyfen. The mixtures according to the present invention, etiprole or pyriproxyfen are effective by contact. Furthermore, the mixtures according to the present invention, etiprole or pyriproxyfen can be applied to any and all stages of development.

[33] The mixtures according to the present invention, etiprole and pyriproxyfen, can be applied as such or in the form of compositions comprising them as defined above.

[34] As used herein, the term “contact” includes direct contact (application of the compounds / mixtures / compositions directly onto the pest animal or plant, typically to the foliage, stems or roots of the plant) and indirect contact (application of the compounds / mixtures / compositions to the site, i.e., habitat, growth site, plant, seed, soil, area, material or environment in which the pest is growing or may grow, of the pest animal and / or plant).

[35] The term “animal pest” includes arthropods, gastropods and nematodes. Preferred pests according to the present invention are arthropods, preferably insects and arachnids, particularly insects. Insects that are of specific relevance to crops are typically referred to as crop pest insects.

[36] The term “harvest” refers to growing and harvested crops.

[37] The term “plant” includes cereals, such as durum wheat and others, barley, rye, triticale, oats, rice or maize (forage maize, sweet maize and field maize); beet, such as sugar beet or fodder beet; fruits, such as pomes, drupes or soft fruits, such as Petition 870250013436, dated 19 / 02 / 2025, p. 14 / 22 11 / 13 apples, pears, plums, peaches, nectarines, almonds, cherries, papayas, strawberries, raspberries, currants or blackcurrants; leguminous plants, such as beans, lentils, peas, alfalfa or soybeans; oilseed plants, such as rapeseed (canola), wild turnip, mustard, olives, sunflower, coconut, cocoa beans, castor plants, oil palm, peanuts or soybeans; cucurbits, such as pumpkins, squash, cucumbers or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruits, such as oranges, lemons, grapefruits or tangerines; vegetables, such as eggplant, spinach, lettuce (e.g., iceberg lettuce), endive, cabbage, asparagus, carrots, onions, garlic, leeks, tomatoes, potatoes, cucurbits or bell peppers; Lauraceous plants, such as avocados, cinnamon or camphor; raw material and energy plants, such as corn, soybeans, canola, sugar cane or oil palm; tobacco; almonds, such as walnuts; pistachios; coffee; tea; bananas;Grapes (table grapes and juice grapes); hops; sweetener leaf (also known as stevia); natural rubber plants or forest and ornamental plants, such as flowers (e.g., carnations, petunias, geraniums / Pelargonium, pansies, and impatiens), shrubs, broadleaf trees (e.g., poplar), or perennials such as conifers; eucalyptus; grass; turf; grass for animal feed or ornamental uses. Preferred plants include potatoes, beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, canola, legumes, sunflowers, coffee, or sugarcane; fruits; grapes; ornamental plants; or vegetables such as cucumbers, tomatoes, beans, or pumpkins.

[38] The term “plant propagation material” designates all reproductive parts of the plant, such as seeds and plant material such as cuttings and tubers (e.g., potatoes), which can be used for plant propagation. This includes seeds, roots, fruits, tubers, Petition 870250013436, dated 19 / 02 / 2025, page 15 / 22 12 / 13 bulbs, rhizomes, shoots, seedlings and other plant parts. Seedlings and young plants that need to be transplanted after germination or emergence from the soil can also be included. These plant propagation materials can be prophylactically treated with a plant protection mixture at planting, transplanting or before transplanting.

[39] The term “seed” encompasses seeds and plant propagules of all kinds, including, but not limited to, true seeds, seed pieces, buds, stolons, bulbs, fruits, tubers, grains, cuttings, cut shoots and the like, and indicates, in a preferred embodiment, true seeds.

[40] Generally, “effective amount as an insecticide” indicates the amount of active ingredient required to achieve an observable effect on growth, including the effects of necrosis, death, retardation, prevention and removal, destruction or otherwise reduction of the occurrence and activity of the target organism. The effective amount as an insecticide may vary for the various compounds / mixtures / compositions used in the present invention. An effective amount as an insecticide of the compositions will also vary according to prevailing conditions, such as the desired insecticidal effect and duration, weather conditions, target species, location, method of application and the like.

[41] For use in the treatment of producing plants, for example, by means of foliar application, the application rate of the active ingredients according to the present invention may be in the range of 0.0001 L to 1000 L.

[42] As used herein, “effective and non-phytotoxic quantity” indicates that the mixture, etiprole and pyriproxyfen, is used in a quantity that allows the desired effect to be obtained, but that does not generate any phytotoxic symptoms on the treated plant or on the plant grown from it. Petition 870250013436, dated 19 / 02 / 2025, page 16 / 22 13 / 13 treated propagule or treated soil. Petition 870250013436, dated 19 / 02 / 2025, page 17 / 22

Claims

1 / 2 CLAIMS 1. Insecticidal composition, characterized by comprising at least one compound selected from the group consisting of etiprole and pyriproxyfen, in a formulation suitable for pest control.

2. Insecticidal composition, according to claim 1, characterized in that said compound is present in a weight ratio ranging from 1:100 to 100:1, including 1:1, dissolved in at least one solvent selected from the group consisting of organic, aqueous or mixed solvents.

3. Insecticidal composition, according to any of the preceding claims, characterized in that it may include additives selected from the group consisting of emulsifiers, dispersants, surfactants, stabilizers, pH regulators, preservatives and synergistic agents.

4. Pest control process, characterized by comprising the application of the composition according to any of claims 1 to 3 on at least one substrate selected from the group consisting of plants, plant propagation materials, growing environment, surfaces or spaces subject to pest attack.

5. A method for applying pesticides, characterized by comprising the administration of a composition conforming to any one of claims 1 to 3 to at least one target selected from the group consisting of pests, pest habitats, pest food sources, or surfaces subject to infestation.

6. Method according to claim 5, characterized in that the targets include pest insects belonging to at least one order selected from the group consisting of Hemiptera, Coleoptera, Lepidoptera and Diptera.

7. A method conforming to any one of claims 5 to 6, characterized in that it comprises the treatment of at least one element selected from the group consisting of pests, food sources, growing environments, plants, seeds, soils, surfaces or spaces to be protected against infestation.

8. Method according to any one of claims 5 to 7, characterized in that the application of the composition is carried out by at least one means selected from the group consisting of foliar spraying, seed treatment, soil application or misting, at a dosage ranging from 1 g to 10,000 g per hectare. Petition 870250013436, dated 19 / 02 / 2025, pp. 19 / 22