Automated analysis system using individually operated biological devices, analysis method and storage medium

Description

"Automated analysis system using individually operated biological devices, analysis method and storage medium" FIELD OF TECHNIQUE

[001] The present disclosure relates to an automated analysis system that operates as a complete automation system through the operational connection of autonomous devices and, more particularly, to an automated analysis system including a device for preparing samples for analysis and a device for analyzing the samples that are operated individually, an analysis method and a storage medium. BASIC TECHNOLOGY OF THE INVENTION

[002] The PCR test for diagnosing a disease performs a testing process, such as nucleic acid extraction, PCR setup, amplification reaction and reaction analysis, and in this case, several devices are used to perform each step.

[003] For example, nucleic acid extraction equipment can be used to extract nucleic acid from a specimen, a liquid dispensing device to prepare a sample for analysis, a real-time PCR device to perform amplification and reaction analysis, and the like.

[004] These various devices are used autonomously, and the user installs containers for reagents, specimens and / or analysis samples for each test step on each device or moves containers from one device to another.

[005] External contamination can occur when the specimen, reagent, and / or sample container is mounted on each device or moved to another device by the user. Additionally, human testing error can occur by the user.

[006] Several devices have been developed to solve this problem. One option is a Complete Automation System. Petition 870260047759, dated 05 / 19 / 2026, page 13 / 317 2 / 143

[007] Currently, several complete automation systems are used in large medical institutions and large inspection institutions. Representatively, there are Roche's Cobas 6800 / Cobas 8800, Hologic's Panther / Panther Fusion, Abbott's Alinity, and Qiagen's QIAsymphony.

[008] These devices can operate some or all of the various processes for diagnostic testing on an integrated device as a step to provide a result.

[009] However, since the conventional complete automation system is implemented as a system from the moment the device is developed, it is not possible to individually perform nucleic acid extraction, PCR setup, amplification reaction, reaction analysis and the like.

[010] Furthermore, conventional full-scale automation systems are manufactured in a considerably large size in order to implement multiple processes for a diagnostic test in one system, and have a high acquisition cost. Therefore, there is also a problem in that it is difficult to develop multiple diagnostic reagents due to the problem of not being easily introduced by small and medium-sized hospitals and small and medium-sized inspection institutions.

[011] Because the conventional system has low equipment applicability, it is not easy to apply an additionally developed diagnostic reagent. Furthermore, even when a partial equipment error occurs, it can be difficult to use the entire equipment.

[012] Additionally, in an unusual situation where large-scale diagnostic testing takes place, it is necessary to operate each test device individually for rapid testing, but the conventional system cannot use each part x individually. Even if it could be used separately, it was impossible to remove and use the device separately. Petition 870260047759, dated 05 / 19 / 2026, page 14 / 317 3 / 143

[013] When diagnostic kit development companies and research institutes that have conventional systems develop diagnostic reagents, the development and experiments are carried out using the entire system, so it is not easy for small-scale diagnostic kit development companies and research institutes to develop a reagent.

[014] Even if it is carried out in large-scale diagnostic kit development companies and research institutes, if a large number of devices are not installed, there is the problem that the diagnostic reagent development period cannot be achieved in a short period of time. SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED

[015] One objective of the present disclosure is to combine individual autonomous biological devices for molecular diagnostic testing or research into a modular type and to integrate the modular type into an automated analysis system.

[016] Another objective of the present disclosure is to integrate and operate individually operated biological devices as an integrated system and to easily and quickly disassemble the biological devices, if necessary, to be operated individually again.

[017] Another objective of the present disclosure is to integrate and operate devices as an automated analysis system, while at the same time minimizing structural changes to biological devices.

[018] Another objective of the present disclosure is to enable biological devices that are operated wholly by an automated analysis system to use molecular diagnostic test reagents that have been conventionally used without any modifications.

[019] Another objective of the present disclosure is to integrate and operate an automated analysis system through a modular combination of devices. Petition 870260047759, dated 05 / 19 / 2026, page 15 / 317 4 / 143 individually operated biological devices and involve some or all of the devices, thereby enhancing user convenience and reducing the footprint.

[020] Another objective of the present disclosure is to provide a means of controlling the environment inside an enclosure, so that a change in the environment in which a device is operated does not occur when at least one of the biological devices that are operated individually is enclosed.

[021] Another objective of the present disclosure is to form a defined passage through which a reaction vessel commonly used by biological devices is transported, so that the reaction vessel can be easily transported from one or more devices.

[022] Another objective of the present disclosure is to provide a robotic module for transporting a reaction vessel so that the reaction vessel can be easily transported through a defined passage between biological devices.

[023] Another objective of the present disclosure is to provide a combination device that has the capability to combine two or more biological devices that are operated individually, so that they can be integrated and operated in an automated analysis system.

[024] Another objective of the present disclosure is to perform a test using an existing diagnostic reagent without altering the diagnostic reagent, even when individually operated biological devices are modularly combined and integrated into an automated analysis system.

[025] Another objective of the present disclosure is to combine individually licensed biological devices with an automated analysis system so that the biological devices can be integrated and operated, and operate the biological devices without requiring a new license for each device. Petition 870260047759, dated 05 / 19 / 2026, page 16 / 317 5 / 143 WAYS TO SOLVE PROBLEMS

[026] To achieve these objectives and other advantages and in accordance with the purpose of the disclosure, as incorporated and extensively described herein, an automated analysis system is provided comprising: a preparation device for preparing an analysis sample in a reaction vessel, wherein the preparation device is a self-contained device; an analysis device for analyzing the prepared analysis sample in the reaction vessel, wherein the analysis device is a self-contained device; a transport device for transporting the reaction vessel; and an enclosure, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure; wherein the preparation device and the enclosure comprise a defined passage through which the reaction vessel is transported and the transport device transports the reaction vessel through the defined passage;where the autonomous device can operate independently when separated from the automated analysis system.

[027] In another aspect of the present disclosure, a method of analysis using an automated analysis system is provided, wherein the automated analysis system includes a preparation device, an analysis device, a transport device, a control module, and an enclosure, wherein the method of analysis includes: controlling, by the control module, the transport device so that a reaction vessel containing an analysis sample is transported from the preparation device to the analysis device; wherein the preparation device and the analysis device are autonomous devices; controlling, by the control module, the analysis device so that the analysis sample is analyzed in the analysis device; and controlling, by the control module, the transport device so that the reaction vessel in which the analysis of the analysis sample is completed is removed from the analysis device, wherein at least one Petition 870260047759, dated 05 / 19 / 2026, page 17 / 317 6 / 143 The device selected from the group consisting of the analysis device and the transport device is located within an enclosure; the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, and the transport device transports the reaction vessel through the defined passage.

[028] According to another aspect of the present disclosure, to achieve the objective, an automated analysis system is provided including: a memory; at least one processor configured to access the memory; and at least one program stored in memory and configured to be executed by the processor, wherein the automated analysis system includes: a preparation device; an analysis device; a transport device; a control module; and an enclosure, wherein the at least one program includes instructions that, when executed by the at least one processor, cause the following steps to be performed: controlling, by the control module, the transport device so that a reaction vessel containing an analysis sample is transported from the preparation device to the analysis device; the preparation device and the analysis device being autonomous;to control, via the control module, the analysis device so that the sample is analyzed in the analysis device; to control, via the control module, the transport device so that the reaction vessel in which the analysis of the sample is completed is removed from the analysis device; wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure, wherein the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, wherein at least one program includes instructions that cause the transport device to transport the reaction vessel through the defined passage. Petition 870260047759, dated 05 / 19 / 2026, page 18 / 317 7 / 143

[029] In order to achieve another objective of the present disclosure, a computer-readable non-transient storage medium is provided that has instructions which, when executed by one or more processors, cause an analysis method using an automated analysis system to be performed, wherein the automated analysis system includes a preparation device, an analysis device, a transport device, a control module and an enclosure, wherein the method includes: controlling, by the control module, the transport device so that a reaction vessel containing an analysis sample is transported from the preparation device to the analysis device; wherein the preparation device and the analysis device are autonomous devices; controlling, by the control module, the analysis device so that the analysis sample is analyzed in the analysis device;and control, via the control module, the transport device so that the reaction vessel in which the analysis of the sample is completed is removed from the analysis device, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure, the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, and the instructions cause the transport device to transport the reaction vessel through the defined passage.

[030] According to another aspect of the present disclosure, a method is provided for controlling a fan module in an automated analysis system, wherein the automated analysis system includes: a preparation device for preparing an analysis sample in a reaction vessel; an analysis device for analyzing the prepared analysis sample in the reaction vessel; a transport device for transporting the reaction vessel; an enclosure; a door part for opening and closing a defined passage; and a fan module that operates to discharge air from an internal space of the enclosure; wherein Petition 870260047759, dated 05 / 19 / 2026, page 19 / 317 8 / 143 at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure, wherein the preparation unit and the enclosure each include a defined passage through which the reaction vessel is transported, and wherein the control method of the fan module includes: opening the defined passage by the door part; and interrupting an operation of the fan module while the defined passage is open by the door part.

[031] To further achieve these and other advantages and in accordance with the purpose of the present disclosure, a method is provided for manufacturing an assembly of a molecular diagnostic device, wherein the assembly includes a self-contained analysis device, a transport device and a self-contained preparation device, wherein the transport device carries a reaction vessel; the self-contained preparation device provides a reaction vessel containing a sample analyzable by the self-contained analysis device; the self-contained analysis device analyzes the sample contained in the reaction vessel; wherein the method includes the following steps: (a) providing the self-contained analysis device and the self-contained preparation device to the transport device;and (b) align the autonomous analysis device, the transport device and the autonomous preparation device, wherein the alignment forms a motion path for the reaction vessel between the autonomous preparation device and the autonomous analysis device. EFFECTS OF THE INVENTION

[032] The features and advantages of this disclosure are summarized as follows.

[033] (1) The automated analysis system, analysis method and storage medium of the present disclosure can facilitate an operational connection between two devices by providing a transport device that has the capacity to provide a reaction vessel between a preparation device and Petition 870260047759, dated 05 / 19 / 2026, page 20 / 317 9 / 143 an analytical device used individually for the analysis of a sample.

[034] (2) The automated analysis system, analysis method and storage medium according to the present disclosure are advantageous due to the fact that they can provide convenience of use in that conventional stand-alone biological devices can be operationally connected to be used as an automated analysis system.

[035] (3) The automated analysis system, analysis method and storage medium of the present disclosure can be used as being integrated into an automated analysis system through the operational connection of a plurality of devices that were used independently and, if necessary, can be disassembled again to be used independently.

[036] (4) The automated analysis system, analysis method and storage medium according to the present disclosure can combine separately used biological devices, but combine them without any alteration to the internal structure of the device, thus allowing the combined device to be used without the need for additional authorization or licensing.

[037] (5) The automated analysis system, analysis method and storage medium according to the present disclosure can be combined for the purpose of not requiring additional approval or licensing for biological devices integrated into the automated analysis system, thus allowing each device to use a reagent without altering the conventional reagent.

[038] (6) The automated analysis system, analysis method and storage medium according to the present disclosure are advantageous due to the fact that the reaction vessels used by biological devices combined with the automated analysis system can be supplied to each device through a transport device, thus avoiding human test errors. Petition 870260047759, dated 05 / 19 / 2026, page 21 / 317 10 / 143

[039] (7) The automated analysis system, analysis method and storage medium of the present disclosure combine biological devices into an automated analysis system and two or more devices are included, thereby protecting the analysis samples from contamination from the external environment.

[040] (8) The automated analysis system, analysis method and storage means of the present disclosure can prevent the reaction vessel from coming into contact with external contamination by enclosing at least one of the analysis device and the transport device. BRIEF DESCRIPTION OF THE DRAWINGS

[041] Figure 1 is a front view illustrating an automated analysis system according to an embodiment of the present disclosure.

[042] Figure 2 is a right side view illustrating an automated analysis system according to an embodiment of the present disclosure.

[043] Figure 3 is an illustrative diagram that shows an operational connection of the automated analysis system according to an embodiment of the present disclosure.

[044] Figure 4 is an internal front view illustrating an automated analysis system according to an embodiment of the present disclosure.

[045] Figure 5 is a perspective view illustrating a self-contained preparation device according to an embodiment of the present disclosure.

[046] Figure 6 is a perspective view illustrating an enclosure according to an embodiment of the present disclosure.

[047] Figure 7 is an illustrative diagram to illustrate an operational state of a defined passage of an enclosure according to an embodiment of the present disclosure. Petition 870260047759, dated 05 / 19 / 2026, page 22 / 317 11 / 143

[048] Figure 8 is an internal perspective view illustrating an enclosure of the automated analysis system according to an embodiment of the present disclosure.

[049] Figure 9 is a perspective view illustrating a transport device according to an embodiment of the present disclosure.

[050] Figure 10 is a perspective view illustrating a lifting module of the transport device according to an embodiment of the present disclosure.

[051] Figure 11 is a perspective view illustrating a crane module of the transport device according to an embodiment of the present disclosure.

[052] Figure 12 is a perspective view illustrating a rotation component of a crane module according to an embodiment of the present disclosure.

[053] Figure 13 is a perspective view illustrating a self-contained analysis device according to an embodiment of the present disclosure.

[054] Figure 14 is a perspective view illustrating an automatic seal according to an embodiment of the present disclosure.

[055] Figure 15 is an illustrative diagram that shows a conveyor for retrieving a reaction vessel according to an embodiment of the present disclosure.

[056] Figures 16A and 16B are perspective views illustrating a solution collection compartment according to an embodiment of the present disclosure.

[057] Figure 17 is an exemplary first view illustrating a horizontal extension movement of a lifting module in an enclosure according to an embodiment of the present disclosure. Petition 870260047759, dated 05 / 19 / 2026, page 23 / 317 12 / 143

[058] Figure 18 is a second exemplary view illustrating a horizontal extension movement of a lifting module in an enclosure according to an embodiment of the present disclosure.

[059] Figure 19 is an exemplary first view illustrating the transport of a reaction vessel from a lifting module and a crane module according to an embodiment of the present disclosure.

[060] Figure 20 is a second exemplary view illustrating the transport of a reaction vessel from a lifting module and a crane module according to an embodiment of the present disclosure.

[061] Figure 21 is an illustrative diagram showing an assembly operation of a reaction vessel in an automatic seal according to an embodiment of the present disclosure.

[062] Figure 22 is an illustrative diagram that shows an assembly operation of a reaction vessel in an analysis device according to an embodiment of the present disclosure.

[063] Figure 23 is an illustrative diagram that illustrates an operation of a lifting module according to an embodiment of the present disclosure.

[064] Figure 24 is a perspective view illustrating a horizontal extension movement of a lifting module in a preparation device according to an embodiment of the present disclosure.

[065] Figure 25 is an exemplary view illustrating a crane module according to an embodiment of the present disclosure carrying a reaction vessel in the lifting module.

[066] Figure 26 is an exemplary view illustrating a crane module according to an embodiment of the present disclosure that mounts a reaction vessel in an automatic seal. Petition 870260047759, dated 05 / 19 / 2026, p. 24 / 317 13 / 143

[067] Figure 27 is an exemplary view illustrating a crane module according to an embodiment of the present disclosure mounting a reaction vessel on an analysis device.

[068] Figure 28 is an exemplary first view illustrating a recovery operation of a reaction vessel using a carrier according to an embodiment of the present disclosure.

[069] Figure 29 is a second exemplary view illustrating a recovery operation of a reaction vessel using a carrier according to an embodiment of the present disclosure.

[070] Figure 30 is an internal plan view illustrating the interior of an enclosure according to an embodiment of the present disclosure.

[071] Figure 31 is an internal perspective view illustrating the interior of an enclosure according to an embodiment of the present disclosure.

[072] Figure 32 is an illustrative diagram that illustrates an analysis device that is mounted in an enclosure using a positioning means according to an embodiment of the present disclosure.

[073] Figure 33 is a first illustrative diagram that illustrates a means of positioning according to an embodiment of the present disclosure.

[074] Figure 34 is a second illustrative diagram that illustrates a means of positioning according to an embodiment of the present disclosure.

[075] Figure 35 illustrates a fan module that is a means of environmental control within an enclosure according to an embodiment of the present disclosure.

[076] Figure 36A illustrates a self-contained preparation device according to an embodiment of the present disclosure provided in a transport unit. Figure 36B is a view to describe the self-contained preparation device. Petition 870260047759, dated 05 / 19 / 2026, page 25 / 317 14 / 143 aligned with the transport unit, e. Figure 36C is a view illustrating the internal structure of a housing for the self-contained preparation device.

[077] Figure 37A illustrates a self-contained analysis device according to an embodiment of the present disclosure. Figure 37B illustrates the self-contained analysis device according to an embodiment of the present disclosure provided within an enclosure of a transport unit.

[078] Figure 38 is a layout diagram illustrating components of a preparation device according to an embodiment of the present disclosure located on a platform.

[079] Figure 39 is a flowchart to illustrate an operational method of an automated analysis system according to an embodiment of the present disclosure.

[080] Figure 40 is a conceptual diagram that conceptually illustrates a configuration of an automated analysis system according to an embodiment of the present disclosure.

[081] Figure 41 is a block diagram that conceptually illustrates a configuration of a part of HW of a preparation device.

[082] Figure 42 is a block diagram that conceptually illustrates a configuration of a preparation device management unit included in a preparation device.

[083] Figure 43 is a block diagram that conceptually illustrates a configuration of a part of HW of an analysis device.

[084] Figure 44 is a block diagram that conceptually illustrates a configuration of an analysis device management unit included in an analysis device. Petition 870260047759, dated 05 / 19 / 2026, page 26 / 317 15 / 143

[085] Figure 45 illustrates by way of example a path through which a reaction vessel is transported by a transport device in an automated analysis system according to one embodiment.

[086] Figure 46 is a block diagram that conceptually illustrates a transport module configuration.

[087] Figure 47 is a block diagram that conceptually illustrates a configuration of an automatic seal.

[088] Figure 48 is a view that exemplarily illustrates a direction of movement of a transport device in an automated analysis system according to a modality.

[089] In each of Figures 49 to 56, an example of the operating concept of a fan module is illustrated, which is controlled according to a position or direction of movement of a transport device or, according to the possibility of the passage cavity being open or closed in an automated analysis system, according to a modality.

[090] Figure 57 is a flowchart of a fan module control method that can be performed by an automation analysis system according to one embodiment. DETAILED DESCRIPTION OF THE INVENTION

[091] The present disclosure will now be described in more detail with reference to the modalities of the present disclosure. These modalities are provided only to describe the present disclosure in more detail, and it will be evident to those skilled in the art that the scope of the present disclosure is not limited by these modalities according to the essence of the present disclosure.

[092] Furthermore, terms such as first, second, A, B, (a), (b), (i) and (ii) may be used in describing the elements of the present revelation. The term is used only to distinguish the elements from other elements, and the nature, Petition 870260047759, dated 05 / 19 / 2026, page 27 / 317 16 / 143 The sequence or order of corresponding elements is not limited by the term. When an element is described as being connected, coupled, or joined to another element, the element may be directly connected or joined to the other element, but it should be understood that other elements may be connected, coupled, or joined between the respective elements. AUTOMATED ANALYSIS SYSTEM

[093] The present inventors have made intensive efforts to develop a system, a method, and the like that are intended to interconnect and use various devices that perform a processor to detect a target nucleic acid through amplification of the target nucleic acid. As a result, the present inventors have configured such a way that a preparation device and an analysis device, which are autonomous biological devices operated individually and used to detect a target nucleic acid, can be connected and used operationally. That is, an automated analysis system has been developed configured to provide reaction vessels used in a preparation device and an analysis device, which are operated independently, from the preparation device to the analysis device using a transport device.

[094] As used in this document, the term automated analytical system includes a preparation device for preparing an analytical sample including or presumed to include an analyte, and an analytical device for amplifying a nucleic acid having a specific nucleotide sequence in the prepared analytical sample and detecting the amplified nucleic acid. The preparation device and the analytical device are individually operated, stand-alone devices. The preparation device and the analytical device may be applied to the automated analytical system in a licensed state as a stand-alone device. Alternatively, for application to an automated analytical system, Petition 870260047759, dated 05 / 19 / 2026, page 28 / 317 17 / 143 Some accommodations may be altered, and partial licensing may be carried out.

[095] Therefore, the preparation device and the analysis device are used in the stand-alone device, and the approved and licensed reagent can be used as is.

[096] The automated analysis system includes one or more defined passages and transport devices to operationally connect the preparation device and the analysis device, each of which is operational. The defined passage may be a passage cavity.

[097] As used in this document, the term sample refers to a material that includes or is presumed to include an analyte.

[098] A “sample” includes biological samples (e.g., cells, tissues, and body fluids from biological sources) and non-biological samples (e.g., food, water, and soil).

[099] The biological sample may include, but is not limited to, viruses, bacteria, tissues, cells, blood (including whole blood, plasma and serum), lymph, bone marrow fluid, sputum, smear, aspiration, bronchial lavage fluid, alveolar bronchial lavage fluid, nasal lavage fluid, milk, urine, feces, ocular fluid, saliva, semen, brain extract, cerebrospinal fluid (CS), arthroid fluid, appendix, spleen and tonsil tissue extract, amniotic fluid and ascites.

[0100] The sample may also include naturally occurring nucleic acid molecules and synthetic nucleic acid molecules isolated from a biological source.

[0101] In one embodiment, the term sample may include a substance used for the preservation, processing, detection, and the like of the sample. The sample may include an amplification reagent, a detection reagent, a preservative, water, deionized water, a saline solution, a pH buffer, a Petition 870260047759, dated 05 / 19 / 2026, page 29 / 317 18 / 143 acidic solution and an additional material, such as a basic solution, but without limitation to the same.

[0102] The term raw sample used in this document may refer to a sample before it is used in a sample processing device for analysis.

[0103] The term raw sample as used in this document may be used to indicate a sample before it has been processed in a sample preparation device.

[0104] The term analytical sample used in this document may refer to intermediates including analytes prepared in the course of various sample processing steps for analysis.

[0105] Can be used to indicate samples prepared in the processing on a preparation device and an analysis device for sample preparation. In particular, it can be used to represent a sample analyzed on an analysis device.

[0106] As used in this document, the term specimen may refer to an object to be analyzed that is collected from food, soil, air, water, or living organisms. In general, a specimen includes sputum, blood, urine, feces, etc. A specimen container including a specimen may include a sample collection composition for collecting a specimen and / or a specimen transport medium. The medium for transporting a sample performs a deactivation function due to the lysis of an infectious pathogen and a stabilization function for nucleic acid materials released from the disturbed pathogen.

[0107] The term “specimen” may be used interchangeably with the term “sample”. In particular, in one embodiment, the analyte is an antigen, antibody, enzyme, or nucleic acid. Petition 870260047759, dated 05 / 19 / 2026, p. 30 / 317 19 / 143

[0108] In one specific embodiment, the analyte is a nucleic acid. When the analyte to be analyzed in this document is a nucleic acid molecule, the nucleic acid can be extracted from a specimen through a nucleic acid extraction process known in the art (See: Sambrook, J. et al., Molecular Cloning. A Laboratory Manual, 3rd ed. Cold Spring Harbor Press (2001)). The nucleic acid extraction process may vary depending on the type of specimen. Furthermore, when the extracted nucleic acid is RNA, a reverse transcription process to synthesize cDNA may additionally be performed (See: Sambrook, J. et al., Molecular Cloning. A Laboratory Manual, 3rd ed. Cold Spring Harbor Press (2001)).

[0109] One or more types of analytes may be included in the sample, and a plurality of analytical samples for detection may be prepared for detection of the same.

[0110] As used in this document, the term preparation device refers to a device used to prepare a sample for analysis. The preparation device is a self-contained device that is operated individually.

[0111] In one embodiment of the revelation, the preparation device includes a housing and the preparation device may be located within a closed enclosure in the form of a separate hexahedron.

[0112] The preparation device can provide the reaction vessel contained within it to the analysis device.

[0113] In one embodiment of the present disclosure, the preparation device may provide an internal reaction vessel for the analysis device through one or more passage cavities formed in the housing.

[0114] In another embodiment of the present disclosure, the preparation device may form one or more definite passages (first passage) Petition 870260047759, dated 05 / 19 / 2026, page 31 / 317 20 / 143 defined) in the housing, in order to provide the reaction vessel inside for the analysis device. The defined passage may be a passage cavity.

[0115] In another embodiment of the present disclosure, when the preparation device is located inside the housing and the analysis device is located outside the housing, the housing may be formed with one or more defined passages to provide the reaction vessel from the preparation device to the analysis device.

[0116] As used in this document, the term preparation device refers to a device for preparing an analytical sample that includes, or is presumed to include, an analyte.

[0117] The preparation device automatically performs a sample preparation process used in the detection of an analyte (e.g., a target nucleotide sequence) using a microrobot, wherein the sample preparation process in the present disclosure includes a nucleic acid extraction process from a specimen, preparation of a reaction mixture for amplification (e.g., a reaction solution for polymerase chain reaction (PCR)), and preparation of a detection sample in which the reaction mixture and the extracted nucleic acid are mixed.

[0118] When the preparation device does not include a nucleic acid extraction module, nucleic acid extraction from the specimen can be performed using a separate device.

[0119] Nucleic acid extraction can be performed using a nucleic acid extraction module to extract nucleic acid from a specimen when the analyte to be analyzed in this document is a nucleic acid.

[0120] That is, when the preparation work to be performed on the preparation device is the preparation of a nucleic acid extract, the actions that consequently lead to the collection of separated nucleic acids should be Petition 870260047759, dated 05 / 19 / 2026, page 32 / 317 21 / 143 performed through a series of nucleic acid separation and purification actions, starting with actions such as fractionating a specimen in a container where the specimen is placed, dispensing a cell lysis solution onto the fractionated specimen, heating, and similar procedures. The preparation of the nucleic acid extract can be carried out using a nucleic acid extraction module included in the preparation device.

[0121] According to one embodiment of the present disclosure, a magnetic sphere-based method using a magnetic sphere that has the ability to bind to a nucleic acid and elute the bound nucleic acid is frequently used in a nucleic acid extraction process from a specimen. The automated nucleic acid extraction method based on a magnetic sphere can be divided into a liquid transfer method and a sphere transfer method according to the type of process of eluting nucleic acids bound to magnetic spheres.

[0122] In addition, the preparation device can perform the task of preparing a reaction mixture for nucleic acid amplification. In one embodiment of the present disclosure, the preparation device can simultaneously perform an operation of preparing a nucleic acid extract and an operation of preparing a reaction mixture for nucleic acid amplification.

[0123] The preparation device performs a sample preparation process, including nucleic acid extraction from a specimen, preparation of a reaction for amplification, and preparation of a reaction mixture in which the substances are mixed. The sample preparation process in the preparation device is implemented through a control device (not shown) to control the preparation device, and an operation of the process of Petition 870260047759, dated 05 / 19 / 2026, page 33 / 317 22 / 143 Preparation of each sample is performed by the control device, which performs the control of each component.

[0124] The control device can be configured to be incorporated into the preparation device and can be supplied as a separate device and connected to the preparation device via a network.

[0125] The control device according to the present disclosure is a type of software control. The control method of the preparation device may be software controlled. The methods implemented as software or algorithms may be stored in a computer-readable record medium as computer-readable code or executable program instructions on a processor.

[0126] Examples of computer-readable recording media include magnetic storage media (e.g., read-only memory (ROM), random access memory (RAM), floppy disk, hard disk, etc.) and optical reading media (e.g., CD-ROM, digital versatile disc (DVD), etc.). Computer-readable recording media can be distributed across networked computer systems so that computer-readable code is stored and executed in a distributed manner. The media can be readable by a computer, stored in memory, and executed by a processor.

[0127] The preparation device according to the disclosure is an automated liquid handling device. The automated liquid handling device can automatically and programmatically aspirate and / or dispense a desired quantity of reagent, sample, or other liquid from a container designed for the automation of a chemical or biochemical laboratory. Several components of automated liquid handling devices are known to those skilled in the art. Petition 870260047759, dated 05 / 19 / 2026, page 34 / 317 23 / 143

[0128] All components of the preparation device are designed as an integrated device and located within the system housing.

[0129] In one embodiment of the present disclosure, the preparation device may use products such as Microlab VANTAGE, Microlab STAR, Microlab NIMBUS, or Microlab Prep from Hamilton Company (see https: / / www.hamiltoncompany.com / automated-liquid-handling / platforms).

[0130] As used in this document, the term analytical device refers to a device used for qualitative or quantitative analysis of an analyte.

[0131] Sample analysis includes detecting the presence of an analyte and measuring its content.

[0132] An analysis device may refer to a device that amplifies a nucleic acid that has a specific nucleotide sequence and detects the amplified nucleic acid.

[0133] The analysis device may include an optical device including a light source and a photodetector.

[0134] The analysis device may include a device that has the ability to heat or cool the sample under analysis through temperature control.

[0135] The analysis device may include a nucleic acid amplifier that performs a nucleic acid amplification reaction through temperature control. Nucleic acid amplifiers typically include thermocyclers.

[0136] In an analytical device, nucleic acid can be amplified in several ways. It can be performed by ligase chain reaction (LCR) (see Wiedmann M, et al., Ligase chain reaction (LCR) - overview and applications. PCR methods and applications, February 1994;3(4):S51-64), gap-filling LCR (GLCR) (see documents WO 90 / 01069, EP Petition 870260047759, dated 05 / 19 / 2026, p. 35 / 317 24 / 143 439182 and WO 93 / 00447), Q-beta replicase amplification (Q-beta) (see Cahill P, et al., Clin Chem., 37(9): 1482-5 (1991), Patent No. 5,556,751), strand displacement amplification (SDA) (see GT Walker et al., Nucleic Acids Res. 20(7):1691-1696 (1992), document EP 497272), nucleic acid sequence-based amplification (NASBA) (see Compton, J. Nature 350(6313):912 (1991)), transcription-mediated amplification (TMA) (see Hofmann WP et al., J Clin Virol. 32(4):289-93 (2005); Patent No. US 5,888,779) and rolling circle amplification (RCA) (see Hutchison CA et al., Proc. Natl Acad. Science. USA. 102:1733217336(2005)).

[0137] A thermocycler, which is a nucleic acid amplification device included in the analytical device of the present disclosure, is usefully used in a nucleic acid amplification reaction based on polymerase chain reaction (PCR). Several nucleic acid amplification methods based on polymerase chain reaction (PCR) are known. For example, quantitative PCR (quantitative PCR), digital PCR, asymmetric PCR, reverse transcription PCR (RT-PCR), differential display PCR (DDPCR), nested PCR, optional initiation PCR (AP-PCR), multiplex PCR, genome typing SNP PCR, etc. are included.

[0138] For example, a thermocycler that is the nucleic acid amplification device of the present disclosure can perform a denaturation step, an annealing step and an extension (or amplification) step in order to amplify deoxyribonucleic acid (DNA) that has a specific nucleotide sequence.

[0139] The denaturation step is a step of separating double-stranded DNA into single-stranded DNA by heating a solution containing a reagent and a sample containing double-stranded DNA, which is a model nucleic acid, to a specific temperature, for example, around 95 °C. The annealing step is a step of providing an oligonucleotide primer that has a sequence of Petition 870260047759, dated 05 / 19 / 2026, page 36 / 317 25 / 143 nucleotides complementary to a nucleotide sequence of a nucleic acid to be amplified, cool the isolated single-stranded DNA to a specific temperature, for example, 60 °C, and ligate the primer to a specific nucleotide sequence of the single-stranded DNA to form a partial DNA primer complex. The extension step performs a solution maintenance step at a specific temperature, for example, 72 °C, after the annealing step to form double-stranded DNA based on the primers of the partial DNA-primer complex by DNA polymerase.

[0140] In one embodiment, the analysis device of the present disclosure can exponentially amplify DNA that has the specific nucleotide sequence that repeats the three steps described above, for example, 10 to 50 times.

[0141] In another embodiment, the analysis device of the present disclosure can simultaneously perform the annealing step and the extension step. In this case, the analysis device can complete the first circulation by performing two steps consisting of a denaturation step and an annealing / extension step.

[0142] In the meantime, a nucleic acid detection device included in the analytical device of the present disclosure is a device for detecting a target nucleic acid in a sample in which the polymerase chain reaction (PCR) is performed via a nucleic acid amplification device and includes an optical module for detecting emission light emitted from a fluorescent material in the target nucleic acid.

[0143] The optical module is an optical mechanism that analyzes (or monitors) in real time the amplification reactions performed in the nucleic acid amplification device. As an embodiment, the optical module may include a plurality of components, such as a light source, an optical filter, a convex lens, a beam splitter, and a photodetector, and may detect fluorescence generated in a nucleic acid amplification reaction performed in the optical module in real time. Petition 870260047759, dated 05 / 19 / 2026, p. 37 / 317 26 / 143

[0144] According to an embodiment of the present disclosure, the analysis device is a real-time detection device.

[0145] According to an embodiment of the present disclosure, the analysis device is a real-time nucleic acid detection device.

[0146] According to an embodiment of the present disclosure, the analysis device is a real-time PCR device.

[0147] The term analytical device used in this document refers to a device for analyzing an analytical sample. The analytical device is a self-contained device that is operated individually.

[0148] In one embodiment of the disclosure, the analysis device includes a housing for the analysis device and the analysis device may be located in a closed enclosure in the form of a separate hexahedron.

[0149] The analysis device can receive a reaction vessel containing an analysis sample from the preparation device.

[0150] The analysis device does not receive the reaction vessel directly from the preparation device, but it can receive the reaction vessel transported from the transport device.

[0151] As used in this document, the term enclosure is a structure in the form of a dwelling formed from one or more enclosed spaces that can be environmentally / spatially separated from the exterior.

[0152] In one embodiment of the present disclosure, the envelope may have a hexahedral shape.

[0153] In another embodiment of the present revelation, the envelope may have a form in which a plurality of hexahedrons are connected. In this case, the interior may be connected to a space or may be separated into a plurality of spaces. Petition 870260047759, dated 05 / 19 / 2026, page 38 / 317 27 / 143

[0154] In one embodiment of the present disclosure, when the preparation device is located outside the housing and the analysis device is located inside, the transport device may be located inside the housing.

[0155] In another embodiment of the present disclosure, when the analysis device is located outside the housing and the preparation device is located inside, the transport device may be located outside the housing.

[0156] In another embodiment of the present disclosure, when the preparation device and the analysis device are located within the housing, the transport device may be located within the housing.

[0157] An automatic seal can be positioned in the enclosure.

[0158] When the preparation device and / or the analysis device is located inside the enclosure, an environmental control means may be included therein to implement an environment in which each device operates as a stand-alone device.

[0159] Environmental control means serve to control temperature, humidity, contamination, etc. within the enclosure and may include a heating device, a cooling device, a humidity control device, a fan module, a filter, etc.

[0160] As used in this document, the term defined passage is a configuration for connecting an environmentally / spatially separated preparation device and an analysis device. The defined passage is a passage through which a reaction vessel prepared by the preparation device is moved to the analysis device or to the analysis device in the enclosure for the purpose of spatially connecting the preparation device and the analysis device that are located adjacent to each other.

[0161] In one embodiment of the present revelation, the defined passage may be a passage cavity. Petition 870260047759, dated 05 / 19 / 2026, page 39 / 317 28 / 143

[0162] In one embodiment of the present disclosure, the defined passage may include a first defined passage formed in the preparation device and a second defined passage enclosed in the housing.

[0163] In another embodiment of the disclosure, the first defined passage and / or the second defined passage may include a gate device that has the capability to block spatially connected states. The gate device may be included in the first defined passage or it may be included in the second defined passage. Alternatively, it may be included in both the first defined passage and the second defined passage.

[0164] The defined passage can be opened when the reaction vessel prepared in the preparation device is moved to the analysis device or to the analysis device in the housing, and can be operated to be closed after the movement is completed.

[0165] The first defined passage is formed in the lower portion of the preparation device and, preferably, may be formed on a platform of the preparation device. The first defined passage formed on the platform of the preparation device is located in the lower portion to provide the reaction vessel for the analysis device or the analysis device located in the housing.

[0166] The second defined passage may be formed on an upper surface, on a side surface or on a lower surface of the casing so that the reaction vessel moving from the first defined passage of the preparation device may enter.

[0167] In addition, the enclosure may include a transport device for transporting the reaction vessel from the first defined passage to the second defined passage.

[0168] As used in this document, the term transport device refers to a device that can transport a used reaction vessel. Petition 870260047759, dated 05 / 19 / 2026, page 40 / 317 29 / 143 in an automated analysis system from a preparation device to an analysis device or an analysis device in an enclosure, and transport and assemble the reaction vessel for each component of the enclosure.

[0169] In one embodiment of the present disclosure, the transport device for moving the reaction vessel from the preparation device to the analysis device may include at least one robotic module.

[0170] In one embodiment of the present disclosure, the robotic module includes a lifting module. The lifting module is a robotic module for moving the reaction vessel up and down and can move the reaction vessel from the preparation device into the enclosure.

[0171] In another embodiment of the revelation, the robotic module includes a crane module. The crane module can transport and assemble the reaction vessel moved into the enclosure to the components inside the enclosure.

[0172] In another embodiment of the revelation, the robotic module includes robotic arms. The robotic arms can move the reaction vessel to a desired position through one or more joint movements.

[0173] The robotic module can be operated in the up / down, forward / backward, left / right directions, but in one embodiment of the present disclosure, the lifting module can be operated in the up / down and left / right directions, and the crane module can be operated in the up / down, forward / backward, left / right directions and rotated.

[0174] As used in this document, the term vessel refers to a space for accommodating a material used in a preparation device and in an analysis device. The material generally includes a solution. The vessel may be used as a “sample vessel” or “reaction vessel” containing the sample for analysis. Furthermore, in this descriptive report, a space that accommodates a material used in the preparation device and in the analysis device may be Petition 870260047759, dated 05 / 19 / 2026, page 41 / 317 30 / 143 used as “container” or “carrier”. Vessel, container and carrier are not specifically distinguished. However, it can be used selectively depending on the device, shape or internal receiving material used.

[0175] Furthermore, the container refers to a vessel used for nucleic acid extraction, amplification reaction solution composition, and amplification reaction setup (e.g., PCR setup) performed in a preparation device. That is, the specimen, at least one extraction reagent, at least one composition for the reaction solution, the main mixture of extracted nucleic acid and reaction solution, and the like may be accommodated in the container, and the analytical sample on which the reaction will be performed via the analytical device may be dispensed into the reaction vessel and accommodated therein. In one embodiment of the disclosure, the container includes a tube, a tube strip, and the like. In another embodiment of the disclosure, the container may include a cartridge, a well plate, or the like.

[0176] The container may have various sizes according to the materials to be accommodated in it, and various means for storing or containing the container may be prepared according to the containers which have various sizes. The means for containing the containers may include a conveyor, a shelf, an adapter and the like, and one or more containers may be inserted and stored in each means.

[0177] In one embodiment of the disclosure, the container may include a lid. In another embodiment of the present disclosure, the container may be sealed using a film or similar.

[0178] As used in this document, the term reaction vessel is a sample vessel that may be received in a sample holder of an analytical device. The reaction vessel may contain a predetermined volume of an analytical sample containing a target nucleic acid or a volume Petition 870260047759, dated 05 / 19 / 2026, page 42 / 317 31 / 143 predetermined sample of an analysis that does not contain a target nucleic acid and is contained in a sample holder to be used for reaction (e.g., amplification) or detection (e.g., fluorescence signal).

[0179] The reaction vessel described in this descriptive report describes a tube that has the capacity to accommodate an analytical sample as an example, but reaction vessels of various materials and shapes can be used according to the shape of the reaction region. The reaction vessel is inserted into a well formed in the reaction region so that a heating and cooling reaction cycle can be carried out. That is, the “reaction vessel” refers to an enclosed space in which the reaction takes place.

[0180] The term reaction vessel can be understood as including one, two, or more reaction vessels. A reaction vessel refers to a unit that has the capacity to receive an analytical sample (e.g., an analyte or reaction mixture). Each test tube, amplification tube, strip tube, well plate, multi-well PCR plate is an embodiment of a reaction vessel comprising one, two, or more.

[0181] In one embodiment of the revelation, one or more reaction vessels may be mounted on the sample holder.

[0182] In another embodiment of the present disclosure, one or more reaction vessels are placed in a multi-well plate (hereinafter referred to as a well plate). A well plate containing one or more reaction vessels may be mounted on the sample holder.

[0183] In another embodiment of the present disclosure, the reaction vessel is a well plate that has the capacity to receive the sample for analysis in one or more wells. A well plate that has received the sample for analysis in one or more wells can be mounted on the sample holder. Petition 870260047759, dated 05 / 19 / 2026, page 43 / 317 32 / 143

[0184] The reaction vessel embodiments describe some embodiments among preferred embodiments to be implemented in the present disclosure. Therefore, it is obvious that the reaction vessel can be implemented variably according to other embodiments.

[0185] The term reaction mixture used in this document may refer to a solution mixed with an analyte to facilitate analyte detection. The reaction mixture may include one or more reaction reagents for amplification.

[0186] Figure 1 is a front view illustrating an automated analysis system according to the present disclosure, and Figure 2 is a right side view illustrating an automated analysis system according to the present disclosure. As shown in Figures 1 and 2, in one embodiment of the present disclosure, an automated analysis system 1000 includes a preparation device 1100 and an enclosure 1300.

[0187] In one embodiment of the present disclosure, the preparation device 1100 can be configured to be located on top of the enclosure 1300.

[0188] In another embodiment of the present disclosure, the preparation device 1100 can be configured to be located on the side of the enclosure 1300.

[0189] In another embodiment of the present disclosure, the preparation device 1100 can be configured to be located on the rear surface of the housing 1300.

[0190] In another embodiment of the present disclosure, the preparation device 1100 can be configured to be located on the front surface of the housing 1300.

[0191] In another embodiment of the present disclosure, the preparation device 1100 may be configured to be located within the enclosure 1300. Petition 870260047759, dated 05 / 19 / 2026, page 44 / 317 33 / 143

[0192] In another embodiment of the present disclosure, the preparation device 1100 can be configured to be located under the enclosure 1300.

[0193] The 1300 envelope is a space that has a closed hexahedral shape.

[0194] The housing 1300 can accommodate at least one of the preparation device 1100, the analysis device 1200 and the transport device 1400.

[0195] In one embodiment of the disclosure, the enclosure 1300 may accommodate one or more of the analysis device 1200 and the transport device 1400.

[0196] In another embodiment of the present disclosure, the enclosure 1300 may accommodate one or more analysis devices 1200.

[0197] In another embodiment of the present disclosure, the enclosure 1300 may accommodate the transport device 1400.

[0198] In yet another embodiment of the present disclosure, the housing 1300 may accommodate the preparation device 1100 and the transport device 1400.

[0199] In another embodiment of the present disclosure, the enclosure 1300 may accommodate the preparation device 1100.

[0200] The 1300 enclosure can provide an operational connection between one or more devices housed within it and externally located devices.

[0201] In one embodiment of the disclosure, the enclosure 1300 encloses a single space. When the enclosure 1300 encloses a single space, at least one of the preparation device 1100, the analysis device 1200, and the transport device 1400 may be located in a single space.

[0202] In another embodiment of the present disclosure, an enclosure 1300 encloses a plurality of spaces. When the enclosure 1300 encloses a plurality of spaces, at least one of the preparation device 1100, the analysis device 1200, and the transport device 1400 may be located in any one of the plurality of spaces or in at least two of the plurality of spaces. Petition 870260047759, dated 05 / 19 / 2026, p. 45 / 317 34 / 143

[0203] For example, in the enclosure 1300 which has a single space, the analysis device 1200 and the transport device 1400 can be located in the same space.

[0204] For example, in the 1300 enclosure which has a plurality of spaces, the analysis device 1200 and the transport device 1400 may be located in different spaces.

[0205] In one embodiment of the present disclosure, the analysis device 1200 and the transport device 1400 may be located inside the housing 1300. In this case, the preparation device 1100 is located outside the housing 1300.

[0206] The casing 1300 is provided with a second passage cavity (2 passage cavity) 1310, which is a defined passage through which the transport device 1400 transports the reaction vessel 1500 to be supplied from the preparation device 1100 to the analysis device 1200 is moved.

[0207] The second passage cavity 1310 of the casing 1300 is a defined passage through which the reaction vessel 1500 is transported, and the transport device 1400 can supply the reaction vessel 1500 from the first passage cavity 1130 of the preparation device 1100 to the analysis device 1200 through the second passage cavity 1310 of the casing 1300.

[0208] The position of the second passage cavity 1310 of the enclosure 1300 may be located on any of the outer surfaces of the enclosure 1300. As illustrated in Figure 6, when the enclosure 1300 has a hexahedron, the second passage cavity 1310 may be formed on an upper surface of the enclosure 1300, but without limitation to this.

[0209] The transport device 1400 can be programmed to transport the reaction vessel 1500 through a path formed from the first cavity. Petition 870260047759, dated 05 / 19 / 2026, page 46 / 317 35 / 143 passage (1 passage cavity) 1130 from the preparation device 1100 to the second passage cavity 1310 of the housing 1300.

[0210] Therefore, it is preferable that each defined passage be located at a distance within a range in which the transport device 1400 can move the reaction vessel 1500.

[0211] The 1300 enclosure can be implemented in a hexahedron, such as a cabinet, a cupboard, a box / enclosure, etc. The 1300 enclosure is configured so that its front / rear / left / right / top / bottom surfaces are closed and at least one 1320 door is provided. The 1320 enclosure door is installed on the front / rear, left / right, etc. so that the user can access the devices and components located therein.

[0212] The enclosure 1300 is not sealed and an air vent 1370 may be formed.

[0213] The housing 1300 may include at least one selected from the group consisting of the preparation device 1100, the analysis device 1200 and the transport device 1400.

[0214] In addition, the 1300 casing can be supplied with an automatic seal 1700 to seal the inlet of the upper surface of the reaction vessel 1500.

[0215] In addition, the housing 1300 can be provided with a liquid waste collection compartment 1330 to recover various solutions used to prepare the analytical sample in the preparation device 1100.

[0216] In addition, the housing 1300 can be supplied with a reaction vessel recovery container 1360 to recover the reaction vessel 1500 in which the analysis is completed in the analysis device 1200.

[0217] In one embodiment of the present disclosure, the reaction vessel recovery container 1360 may be located within the enclosure 1300. Petition 870260047759, dated 05 / 19 / 2026, page 47 / 317 36 / 143

[0218] With reference to Figure 16B, when the reaction vessel recovery container 1361 is located inside the enclosure 1300, the reaction vessel 1500 moved by the crane module 1430 can be accommodated. The reaction vessel recovery container 1361 located therein may include a sensor to detect at least one of the quantity and weight of the reaction vessel 1500 accommodated therein.

[0219] In another embodiment of the present disclosure, the reaction vessel recovery container 1360 may be located outside the enclosure 1300.

[0220] With reference to Figures 15, 28 and 29, the reaction vessel recovery container 1360 located on the outside can recover the reaction vessel 1500 while the reaction vessel 1500 is transported from the inside out through the recovery passage cavity 1340 that connects the inside and outside of the casing 1300.

[0221] A conveyor 1350 can be installed in the recovery passage cavity 1340 that connects the inside and outside of the casing 1300 so that the reaction vessel 1500 can be moved and connected to each other. When the conveyor device 1400 places the reaction vessel 1500 on the inner conveyor 1350 of the casing 1300, the reaction vessel 1500 can be moved by the conveyor 1350 and can be accommodated in the reaction vessel recovery container 1360 located outside the casing 1300.

[0222] In one embodiment of the present disclosure, the conveyor 1350 forms an inclined surface that has an outer portion positioned below an inner portion. The conveyor 1350 can discharge the reaction vessel 1500 out of the enclosure 1300 which has rollers on the inclined surface. The reaction vessel 1500 discharged to the outside can be accommodated in the reaction vessel recovery container 1360. Petition 870260047759, dated 05 / 19 / 2026, page 48 / 317 37 / 143

[0223] In another embodiment of the present disclosure, the conveyor 1350 may be powered. The power may rotate a belt included in the conveyor 1350 to discharge the reaction vessel 1500 placed on the conveyor 1350 out of the enclosure 1300. The reaction vessel 1500 discharged to the outside may be accommodated in the reaction vessel recovery container 1360.

[0224] One or more reaction vessels 1500 housed in the same can be emptied from the reaction vessel recovery container 1360 by the user.

[0225] The recovery passage cavity 1340 in which the interior and exterior of the enclosure 1300 are connected by the conveyor 1350 may include an open / close module (not shown). The open / close module may be opened when the reaction vessel 1500 is moved into the reaction vessel recovery container 1360 and may be closed in other cases. The open / close module may protect the interior of the enclosure 1300 against external contamination.

[0226] In one embodiment of the present disclosure, the enclosure 1300 is not completely sealed and is implemented to be ventilated. For this purpose, the enclosure 1300 includes an environmental control means, and the environmental control means may include an air vent, an exhaust vent, a fan, a temperature control means, a humidity control means, an air filter and the like.

[0227] In Figures 6 and 8 of the present disclosure, at least one air vent 1370 or an exhaust vent 1370 for air circulation in the enclosure 1300 is formed and / or at least one fan 1380 for discharging internal air is formed.

[0228] Figure 3 is an illustrative diagram that shows the operational connection of the automated analysis system according to a modality of Petition 870260047759, dated 05 / 19 / 2026, page 49 / 317 38 / 143 present disclosure. As illustrated in Figure 3, the preparation device 1100 is located above the casing 1300.

[0229] The preparation device 1100 can be installed and operated alone for the preparation of an analytical sample and can be used as the automated analysis system 1000 in operational connection with the enclosure 1300, according to an embodiment of the present disclosure.

[0230] According to one embodiment of the present disclosure, when the preparation device 1100 is combined with the housing 1300 and used as the automated analysis system 1000, the preparation device 1100 can form a first passage cavity 1130 so that the lifting module 1410 provided in the housing 1300 can move into the interior (see Figure 5). The first passage cavity 1130 is an empty space and is a defined passage through which the reaction vessel 1500 is moved by the lifting module 1410.

[0231] When the lifting module 1410 is moved to the preparation device 1100, the preparation device 1100 mounts a reaction vessel 1500 to receive the sample for analysis or a plate (not shown) to receive the reaction vessel 1500 onto the lifting module 1410. The lifting module 1410 moves the mounted reaction vessel 1500 or plate into the enclosure 1300.

[0232] According to one embodiment of the present disclosure, when the preparation device 1100 is positioned in the housing 1300, the preparation device 1100 and the housing 1300 can be coupled together by means of a coupling mechanism (not shown).

[0233] In one embodiment of the present disclosure, when at least one of the preparation device 1100 and the analysis device 1200 is operationally connected to the enclosure 1300 to be used as the automated analysis system 1000, the preparation device 1100 and the analysis device 1200 use the power module used as a standalone device as is. Petition 870260047759, dated 05 / 19 / 2026, page 50 / 317 39 / 143

[0234] In one embodiment of the present disclosure, the preparation device and the analysis device can be powered respectively by separate power sources.

[0235] In one embodiment of the present disclosure, when at least one of the stand-alone preparation device 1100 and the stand-alone analysis device 1200 is operationally connected to the enclosure 1300 to be used as the automated analysis system 1000, the stand-alone preparation device 1100 and the stand-alone analysis device 1200 are devices that have already been marketed and / or licensed as stand-alone devices.

[0236] Therefore, even when operationally connected to the enclosure 1300 and used as an automated analysis system 1000, a separate license may not be required or there may be partial modification.

[0237] Figure 4 is an internal front view illustrating the automation analysis system of the present disclosure. As shown in Figure 4, analysis devices 1200-ae and 1200-b are located under enclosure 1300.

[0238] Enclosure 1300 will be described with reference to Figures 8, 30 and 31.

[0239] Figure 8 is an internal perspective view illustrating an enclosure of the automation analysis system according to an embodiment of the present disclosure. Figure 30 is an internal plan view illustrating the interior of an enclosure according to an embodiment of the present disclosure. Figure 31 is an internal perspective view illustrating the interior of an enclosure according to an embodiment of the present disclosure.

[0240] In one embodiment of the present disclosure, the enclosure 1300 comprises a transport device 1400 for supplying the reaction vessel 1500 prepared in the preparation device 1100 to the analysis devices 1200-a, 1200-b. Petition 870260047759, dated 05 / 19 / 2026, page 51 / 317 40 / 143

[0241] The transport device 1400 is a robotic module and, in particular, includes a lifting module 1410 and a crane module 1430.

[0242] In one embodiment of the present disclosure, the transport device 1400 includes a 1410 lifting module and a 1430 crane module.

[0243] In another embodiment of the present disclosure, the transport device 1400 includes a lifting module 1410.

[0244] In another embodiment of the present disclosure, the transport device 1400 includes a crane module 1430.

[0245] In another embodiment of the present disclosure, the 1400 transport device includes a robotic arm (not shown).

[0246] In another embodiment of the present disclosure, the transport device 1400 may include a mechanical device that has the capacity to transport the reaction vessel 1500.

[0247] In one embodiment of the present disclosure, the lifting module 1410 and the crane module 1430 may be located within the enclosure 1300.

[0248] The lifting module 1410 and the crane module 1430 included in the enclosure 1300 are robotic modules. The robotic module moves the reaction vessel 1500 under the control of the control module 2500 (see Figure 40) included in the automation analysis system 1000.

[0249] An automatic seal 1700 for sealing an inlet of the reaction vessel 1500 may be disposed in the enclosure 1300.

[0250] The enclosure 1300 may be supplied with at least one analysis device, 1200-a, 1200-b, for analyzing the analysis sample received in the reaction vessel 1500.

[0251] In the housing 1300, a liquid waste collection compartment 1330 for recovering various solutions used to prepare the analytical sample in the preparation device 1100 can be positioned. Petition 870260047759, dated 05 / 19 / 2026, page 52 / 317 41 / 143

[0252] A reaction vessel recovery container 1360 for collecting reaction vessel 1500, which has been fully analyzed by analysis devices 1200-ae 1200-b, may be located in enclosure 1300.

[0253] The enclosure 1300 includes a control module 2500 (see Figure 40) that transmits and / or receives data from a plurality of devices operationally connected to the automated analysis system 1000.

[0254] In one embodiment of the present disclosure, the control module can be operationally connected to at least one of the preparation device 1100, the analysis device 1200, the transport device 1400 and / or the automatic sealer 1700a via a communication channel. For example, the communication channel can be connected wirelessly and / or wired.

[0255] In one embodiment of the present disclosure, the control module can control the preparation device, the analysis device, and the transport device to operate in a timely manner. The control module controls the preparation device, the analysis device, and the transport device so that the preparation of the analysis sample using the preparation device and the analysis device of the present disclosure, which are autonomous devices, and the analysis thereof can be performed automatically. Specifically, when the preparation of the analysis sample is completed in the preparation device, the control module controls the transport device to transport the analysis sample to the analysis device.Furthermore, in order to mount the sample for analysis on the analysis device, a signal is provided that must be supplied to the analysis device to mount the sample, and the analysis device then initiates an analysis.

[0256] Additionally, in one embodiment of the present disclosure, the control module may provide an external signal necessary for the operation of the autonomous device. The external signal required for operation may be, for example, a signal that Petition 870260047759, dated 05 / 19 / 2026, page 53 / 317 42 / 143 allows the analysis device to be in a state capable of receiving an analysis sample, a signal that allows the analysis device to start the analysis, and a signal that allows the automatic sealer to start a sealing operation.

[0257] As described above, the control module not only transfers signals between autonomous devices to allow the sample for analysis to be moved from the preparation device to the analysis device, but also provides signals that must be manually entered by a user or similar in the related technique in a timely manner so that the autonomous devices independently perform the unit's work, thus implementing a complete automation system.

[0258] In one embodiment of the present disclosure, the control module can receive a signal indicating that the preparation of the analysis sample is completed in the preparation device 1100 through a communication channel.

[0259] Furthermore, a control signal to move the reaction vessel 1500 from the preparation device 1100 to the analysis device 1200 can be provided to the transport device 1400 through a communication channel.

[0260] In addition, the control module can receive a signal in which the analysis of the analysis sample is completed in the analysis device 1200 through a communication channel.

[0261] In addition, the control module can provide a control signal to move the reaction vessel 1500 from the analysis device 1200 to the reaction vessel recovery container 1360 to the transport device 1400 through a communication channel.

[0262] The enclosure 1300 has a second defined passage 1310 formed on an upper surface thereof, through which the lifting module 1410 passes. Petition 870260047759, dated 05 / 19 / 2026, page 54 / 317 43 / 143 which moves to the preparation device 1100 to receive the reaction vessel 1500.

[0263] According to an embodiment of the present disclosure, the second defined passage 1310 can be described as follows with reference to Figures 6 and 7. Figure 6 is a perspective view illustrating an enclosure according to an embodiment of the present disclosure. Figure 7 is an exemplary diagram to illustrate an operating state of a second passage cavity of an enclosure according to an embodiment of the present disclosure. As shown in Figures 6 and 7, a second defined passage 1310 is formed on the upper surface of the enclosure 1300.

[0264] The second defined passage 1310 is formed to have a size through which a vertical motion guide 1413 and an analytical sample vessel shelf 1416 included in the lifting module 1410 can pass.

[0265] The second defined passage 1310 is formed to connect vertically to the first defined passage 1130 formed on the platform 1110 of the preparation device 1100.

[0266] In one embodiment of the present disclosure, the second defined passage 1310 is formed on the right side of the upper surface of the enclosure 1300 and the first defined passage 1130 is formed on the right side in the plane of the platform 1110.

[0267] In another embodiment of the present disclosure, the second defined passage 1310 can be formed on the left side of the upper surface of the enclosure 1300, and the first defined passage 1130 can be formed on the left side in the plane of the platform 1110.

[0268] In yet another embodiment of the present revelation, the second defined passage 1310 may be formed on the upper side of the upper surface of Petition 870260047759, dated 05 / 19 / 2026, page 55 / 317 44 / 143 enclosure 1300, and the first defined passage 1130 can be formed on the upper side in the plane of the platform 1110.

[0269] In yet another embodiment of the present disclosure, the second defined passage 1310 may be formed on the lower part of the upper surface of the enclosure 1300, and the first defined passage 1130 may be formed on the lower part in the plane of the platform 1110.

[0270] In one embodiment of the present disclosure, the second defined passage 1310 is a passage for moving a part of the lifting module 1410 located within the enclosure 1300 to the preparation device 1100. (See Figure 6)

[0271] In another embodiment of the present disclosure, the second defined passage 1310 is an open passage for moving a part of the lifting module 1410 within the enclosure 1300 to the preparation device 1100, and when the part of the lifting module 1410 does not move into the preparation device 1100, the second defined passage 1310 opened through the door part 1311 provided in the second defined passage 1310 can be closed. (See Figure 7)

[0272] Door section 1311 is provided to block contaminants from outside the enclosure 1300.

[0273] In one embodiment of the present disclosure, the door portion 1311 can be implemented in an articulated manner to be opened / closed on an upper or lower side of the upper surface of the enclosure 1300.

[0274] In another embodiment of the present disclosure, the door part 1311 can be implemented in a sliding manner to be opened / closed by moving on the upper surface of the enclosure 1300.

[0275] In another embodiment of the present disclosure, the gate portion 1311 may be of any type in which the second defined passage 1310 may be Petition 870260047759, dated 05 / 19 / 2026, page 56 / 317 45 / 143 opened and closed by a method other than the hinge method or the sliding method.

[0276] As shown in Figure 7(a), when the lift module 1410 is located inside the enclosure 1300, the door portion 1311 of the second defined passage 1310 is closed.

[0277] As shown in Figure 7(b), when the lifting module 1410 moves into the preparation device 1100, the door portion 1311 of the second defined passage 1310 is open. The door portion 1311 of the second defined passage 1310 is closed after the lifting module 1410 moves into the enclosure 1300.

[0278] According to an embodiment of the present disclosure, the lifting module 1410 can be described as follows with reference to Figures 9 and 10. Figure 9 is a perspective view illustrating a transport device according to an embodiment of the present disclosure. Figure 10 is a perspective view illustrating the lifting module of the transport device according to an embodiment of the present disclosure.

[0279] The lifting module 1410 is a component that has the capacity to receive the reaction vessel 1500 in the preparation device 1100. The lifting module 1410 is representative of an operational form of elevator that can be lifted up to the preparation device 1100 on top of the enclosure 1300 to receive an analysis sample from the preparation device 1100.

[0280] The lifting module 1410 includes a fixed vertical guide 1411 in the form of a fixed pillar within the housing 1300. The fixed vertical guide 1411 includes a fixed guide connector 1412 that moves up / down. The lifting module 1410 includes a vertical movement guide 1413 coupled to the fixed guide connector 1412 of the fixed vertical guide 1411. Petition 870260047759, dated 05 / 19 / 2026, page 57 / 317 46 / 143

[0281] The vertical motion guide 1413 includes a motion guide connector 1414 that is moved up / down. The vertical motion guide 1413 includes a shelf guide 1415 attached to the motion guide connector 1414.

[0282] The lifting module 1410 includes an analytical sample vessel shelf 1416 that receives a reaction vessel above the support guide 1415.

[0283] The lifting module 1410 includes an actuator 1417 configured to provide power to move the vertical motion guide 1413 up / down.

[0284] The vertical fixed guide 1411 is coupled and fixed to at least one of the upper portion, the lower portion and / or the side surface of the interior of the housing 1300. The vertical fixed guide 1411 is coupled to the fixed guide connector 1412. The vertical fixed guide 1414 can move the coupled fixed guide connector 1412 in the up / down direction.

[0285] The vertical fixed guide 1411 can use the energy supplied by the actuator 1417 to move the fixed guide connector 1412 up / down.

[0286] The size of the vertical fixed guide 1411 is equal to or less than the internal height of the housing 1300. As the vertical fixed guide 1411 moves the fixed guide connector 1412 upwards, the vertical movement guide 1413 coupled to the fixed guide connector 1412 can be moved to the preparation device 1100 through the second defined passage 1310.

[0287] The fixed guide connector 1412 coupled to the vertical fixed guide 1411 couples to the vertical movement guide 1413 and the fixed guide connector 1412 moves the vertical movement guide 1413 according to the up / down movement provided by the vertical fixed guide 1411.

[0288] The vertical movement guide 1413 can be moved in the vertical direction according to the drive of the fixed vertical guide 1411. Petition 870260047759, dated 05 / 19 / 2026, p. 58 / 317 47 / 143

[0289] In one implementation of the disclosure, the vertical motion guide 1413 is coupled to the motion guide connector 1414. The vertical motion guide 1413 can move the coupled operating guide connector 1414 in the up / down direction.

[0290] The vertical motion guide 1413 can use the energy supplied by the actuator 1417 to move the motion guide connector 1414 in the up / down direction.

[0291] In another embodiment of the revelation, the vertical motion guide 1413 can be coupled to a fixed component without moving the motion guide connector 1414.

[0292] In an exemplary embodiment of the present disclosure, the operating guide connector 1414 coupled to the vertical motion guide 1413 to receive vertical motion can be coupled to the shelf guide 1415.

[0293] A shelf guide 1415 is coupled to an upper portion of the operating guide connector 1414, and when the fixed vertical guide 1411 moves the vertical movement guide 1413 upwards and the vertical movement guide 1413 moves the shelf guide 1415 upwards, the shelf guide 1415 is moved in the preparation device 1100.

[0294] In another embodiment of the present disclosure, the motion guide connector 1414 can be coupled to the shelf guide 1415.

[0295] When the vertical fixed guide 1411 moves the fixed guide connector 1412 upwards, the shelf guide 1415 can be moved into the preparation device 1100 by the movement of the vertical movement guide 1413 and the operating guide connector 1414.

[0296] The vertical motion guide 1413 uses energy supplied by actuator 1417 or by a separate actuator (not shown) to move the shelf guide 1415 in the up / down direction. Petition 870260047759, dated 05 / 19 / 2026, page 59 / 317 48 / 143

[0297] The support guide 1415 can be coupled to the operating guide connector 1414, and an analytical sample vessel shelf 1416 on which the reaction vessel 1500 can be placed can be positioned in an upper portion.

[0298] The analytical sample vessel shelf 1416 is a space in which the reaction vessel 1500 containing the analytical sample is located in the preparation device 1100. The analytical sample vessel shelf 1416 may be referred to as a pedestal, a support, a stand, or similar.

[0299] The analytical sample vessel shelf 1416 can be moved into the preparation device 1100 by moving the operating guide connector 1414 together with the shelf guide 1415 and can receive the reaction vessel 1500.

[0300] The shelf guide 1415 performs an extension movement in the horizontal direction of the analytical sample vessel shelf 1416 connected to it.

[0301] The extended movement of the analytical sample vessel shelf 1416 can be described with reference to Figures 17, 18, 23 and 24. Figure 17 is a first exemplary view illustrating the horizontal extension movement of the lifting module in the enclosure according to an embodiment of the present disclosure. Figure 18 is a second exemplary view illustrating a horizontal extension movement of the lifting module in the enclosure according to an embodiment of the present disclosure. Figure 24 is a perspective view illustrating a horizontal extension movement of the lifting module in the preparation device according to an embodiment of the present disclosure.

[0302] As shown in Figures 17 and 18, the vertical fixed guide 1411 of the lifting module 1410 moves the fixed guide connector 1412 in the vertical direction using the energy supplied by the actuator 1417 and one part of the fixed guide connector 1412 is coupled to the vertical fixed guide 1411 and the other part is coupled to the vertical movement guide 1413. Petition 870260047759, dated 05 / 19 / 2026, page 60 / 317 49 / 143

[0303] The vertical movement guide 1413 can move into the preparation device 1100 according to the upward movement of the attached fixed guide connector 1412. In addition, the vertical movement guide 1413 can move the operating guide connector 1414 attached to the other side in an up / down direction. The operating guide connector 1414, which moves upward by the operation of the vertical movement guide 1413, can move the shelf guide 1415 connected to its upper portion into the preparation device 1100.

[0304] When shelf guide 1415 is moved into the interior of preparation device 1100, shelf guide 1415 can perform horizontal extension movement on the analytical sample vessel shelf 1416 located in the upper portion by a predetermined distance.

[0305] The transfer module (not shown) provided in the preparation device 1100 picks up and transports the prepared reaction vessel 1500 and places the reaction vessel on the horizontally extended moved analytical sample vessel shelf 1416, thereby enabling the reaction vessel 1500 to be moved into the housing 1300.

[0306] When reaction vessel 1500 is mounted on analytical sample vessel shelf 1416, shelf guide 1415 horizontally moves analytical sample vessel shelf 1416, which has been moved horizontally extended, back to its original position.

[0307] The fixed vertical guide 1411 and / or the vertical movement guide 1413 move the coupled fixed guide connector 1412 and / or the movement guide connector 1414 downwards when the reaction vessel 1500 is ready to be moved into the enclosure 1300. The reaction vessel 1500 is moved into the enclosure 1300.

[0308] The analytical sample vessel shelf 1416 includes a coupling guide (not shown) corresponding to the reaction vessel 1500 mounted on Petition 870260047759, dated 05 / 19 / 2026, page 61 / 317 50 / 143 same. The coupling guide prevents the reaction vessel 1500 from being separated from the analytical sample vessel shelf 1416 during movement.

[0309] In one embodiment of the disclosure, the actuator 1417 can provide energy for the horizontal movement of the analytical sample vessel shelf1416.

[0310] In another embodiment of the revelation, the shelf guide 1415 can be fed by another actuator for the horizontal movement of the analytical sample vessel shelf 1416.

[0311] The actuator 1417 can provide power to move the lifting module 1410 in the housing 1300. One or more actuators 1417 can be supplied and can be located in one or more places.

[0312] In one embodiment of the present disclosure, the actuator 1417 can use a hydraulic motor.

[0313] In another embodiment of the present disclosure, the actuator 1417 may use an electric motor.

[0314] In another embodiment of the present disclosure, the actuator 1417 can be used by combining a hydraulic motor and an electric motor.

[0315] In another embodiment of the present disclosure, the actuator 1417 may use a device that has the capacity to generate energy, except for the hydraulic motor and the electric motor.

[0316] In another embodiment of the present disclosure, the actuator 1417 may use a hydraulic motor, an electric motor and a device that has the capacity to generate energy.

[0317] One or more actuators 1417 may be supplied and may supply power to at least one of the lifting module 1410, the crane module 1430 and / or the analytical sample vessel shelf 1416 in the enclosure 1300.

[0318] According to one embodiment of the present disclosure, crane module 1430 can be described as follows with reference to Figures 9, 11 Petition 870260047759, dated 05 / 19 / 2026, page 62 / 317 Figures 51 / 143 to 12 and 19 to 22. Figure 11 is a perspective view illustrating the crane module of the transport device according to an embodiment of the present disclosure. Figure 12 is a perspective view illustrating a rotation component of the crane module according to an embodiment of the present disclosure. Figure 19 is a first exemplary view illustrating the transport of the reaction vessel from the lifting module and the crane module according to an embodiment of the present disclosure. Figure 20 is a second exemplary view illustrating the transport of the reaction vessel from the lifting module and the crane module according to an embodiment of the present disclosure. Figure 21 is an exemplary diagram illustrating the assembly operation of a reaction vessel in an automatic plate seal according to an embodiment of the present disclosure.Figure 22 is an illustrative diagram showing the assembly operation of a reaction vessel on the analysis device according to an embodiment of the present disclosure. Figure 25 is an illustrative view showing that the crane module according to an embodiment of the present disclosure transports a reaction vessel on the lifting module. Figure 26 is an illustrative view showing that a crane module according to an embodiment of the present disclosure mounts a reaction vessel on an automatic seal. Figure 27 is an illustrative view showing that the crane module according to an embodiment of the present disclosure mounts the reaction vessel on the analysis device.

[0319] As shown in Figures 9, 11 to 12 and 19 to 22, the crane module 1430 performs an operation to move the reaction vessel 1500 received by the lifting module 1410 from the preparation device 1100 to each component of the enclosure 1300.

[0320] In one embodiment of the present disclosure, the crane module 1430 includes a fixed horizontal guide 1431, a horizontal movement guide 1433, Petition 870260047759, dated 05 / 19 / 2026, p. 63 / 317 52 / 143 a claw elevator 1434, a claw rotation module 1436 and a claw 1437 in an upper portion within the housing 1300, and the claw 1437 can move and rotate in the directions of the geometric axes X, Y and Z by the respective guides 1431, 1433 and by the claw rotation module 1436.

[0321] In another embodiment of the present disclosure, the crane module 1430 includes a fixed horizontal guide 1431, a guide connector 1432, a horizontal movement guide 1433, a grab elevator 1434, a grab movement guide 1435 and a grab 1437 on top of the housing 1300, wherein the grab 1437 can be moved in the geometric axes X, Y, Z by the respective guides 1431, 1433 and by the grab elevator 1434.

[0322] The fixed horizontal guide 1431 is coupled to the horizontal movement guide 1433 by a fixed guide connector 1432.

[0323] The fixed horizontal guide 1431 can be supplied in the form of one or more movable rails. The horizontal moving guide 1433 is coupled to the fixed horizontal rail-shaped guide 1431 via the fixed guide connector 1432 and moves in the direction of the geometric X axis.

[0324] The fixed horizontal guide 1431 can be supplied in the form of two rails to stably move the horizontal motion guide 1433, and the horizontal motion guide 1433 can be connected to the two rails to be moved in the direction of the geometric X axis. One of the two rails of the fixed horizontal guide 1431 can move the combined horizontal motion guide 1433 in the direction of the geometric X axis.

[0325] In one embodiment of the present disclosure, the actuator 1417 can supply power to the horizontal fixed guide 1431 to move the horizontal motion guide 1433.

[0326] In another embodiment of the present disclosure, the energy with which the fixed horizontal guide 1431 moves the horizontal motion guide 1433 can be supplied from an actuator (not shown) that is supplied separately. Petition 870260047759, dated 05 / 19 / 2026, p. 64 / 317 53 / 143

[0327] The horizontal motion guide 1433 is coupled to the gripper elevator 1434.

[0328] The horizontal motion guide 1433 is provided in the form of a rail. The claw elevator 1434 is coupled to the horizontal motion guide in rail form 1433 to move in the direction of the geometric axis YA. The horizontal motion guide 1433, which provides the movement in rail form, can move the coupled claw elevator 1434 in the direction of the geometric axis Y.

[0329] In one embodiment of the present disclosure, the force that the horizontal motion guide 1433 moves the gripper elevator 1434 can be provided by the actuator 1247.

[0330] In another embodiment of the present disclosure, the energy with which the horizontal motion guide 1433 moves the claw elevator 1434 can be supplied from an actuator (not shown) that is supplied separately.

[0331] The gripper elevator 1434 is connected to a gripper motion guide 1435 and is coupled to the gripper 1437. The gripper motion guide 1435 is coupled to the gripper elevator 1434 which is moved up / down to be moved in the direction of the geometric Z axis. The gripper list 1243 can move the combined gripper 1437 in the direction of the geometric Z axis.

[0332] The 1434 claw elevator is formed by combining two modules.

[0333] One is a clamping module coupled to the horizontal motion guide 1433 and moved along the geometric Y axis. The other is a moving module that is combined with the gripper motion guide 1435 and moves the gripper 1437 in the up / down direction. (See Figure 12) The gripper motion guide 1435 is combined with the gripper 1437, and the gripper 1437 is moved along the geometric Z axis by the up / down motion provided by the gripper elevator 1434. Petition 870260047759, dated 05 / 19 / 2026, p. 65 / 317 54 / 143

[0334] The gripper 1437 can be moved to the position of the reaction vessel 1500 by operating the gripper elevator 1434 to pick up the reaction vessel 1500. The gripper 1437 can detect pressure to grip the reaction vessel 1500 using a pressure sensor or similar to hold the vessel so that the reaction vessel 1500 is not damaged.

[0335] In one embodiment of the revelation, the claw 1437 has the ability to rotate the retracted reaction vessel 1500.

[0336] As shown in Figure 12, the gripper motion guide 1435 coupled to the gripper elevator 1434 is coupled to the gripper 1437 and the gripper rotation module 1436. The gripper rotation module 1436 can rotate the gripper 1437 as shown in (a) to (b) of Figure 12. The gripper rotation module 1436 is made of a rotary motor.

[0337] In one embodiment of the revelation, the gripper rotation module 1436 can rotate the gripper 1437 by a rotation angle of 90 degrees.

[0338] In another embodiment of the present disclosure, the gripper rotation module 1436 can rotate the gripper 1437 at each rotation angle.

[0339] One or more actuators used in the lifting module 1410 and / or the crane module 1430 can be operated using various driving forces.

[0340] In one embodiment of the present disclosure, at least one or more of the actuators may use a hydraulic motor.

[0341] In another embodiment of the present disclosure, at least one of the actuators may use an electric motor.

[0342] In another embodiment of the present disclosure, at least one or more of the actuators can be used by combining a hydraulic motor and an electric motor. Petition 870260047759, dated 05 / 19 / 2026, page 66 / 317 55 / 143

[0343] In another embodiment of the present disclosure, at least one of the actuators may use a device that has the capacity to generate energy, except for the hydraulic motor and the electric motor.

[0344] In another embodiment of the present disclosure, at least one of the actuators may use a hydraulic motor, an electric motor and a device that has the capacity to generate energy.

[0345] As shown in Figures 19 and 20, crane module 1430 can move gripper 1437 to a position above analytical sample vessel shelf 1416 of lifting module 1410 to move reaction vessel 1500. Crane module 1430 can pick up reaction vessel 1500 after gripper 1437 located on top of analytical sample vessel shelf 1416 is lowered.

[0346] In one embodiment of the present disclosure, the action of crane module 1430 that moves gripper 1437 to the top of analytical sample vessel shelf 1416 is driven by pre-stored position coordinates.

[0347] The automated analysis system 1000 stores all locations to which the crane module 1430 can move within the enclosure 1300 as coordinate information. The crane module 1430 can perform the movement according to coordinate information of a location to be moved.

[0348] In another embodiment of the present disclosure, the action of the crane module 1430 that moves the gripper 1437 over the analytical sample vessel shelf 1416 is driven by pre-stored position coordinates and can be further stopped at position by a position sensor module (not shown) provided in the housing 1300. The position sensor module enables the gripper 1437 to stop at a predetermined position by transmitting and receiving signals between the gripper 1437 and the analytical sample vessel shelf 1416 based on the optical signal. Petition 870260047759, dated 05 / 19 / 2026, page 67 / 317 56 / 143

[0349] The position sensor module can be supplied on the analytical sample vessel shelf 1416, on the automatic sealer 1700, on the analysis devices 1200-ae 1200-b, on the reaction vessel recovery container 1360 or on the conveyor 1350, which are components by which the gripper 1437 moves the reaction vessel 1500.

[0350] The lifting module 1410 and the crane module 1430 of the transport device 1400 included in the housing 1300 receive power to move the reaction vessel 1500.

[0351] The lifting module 1410 receives power from the fixed vertical guide 1411, the vertical movement guide 1413 and / or the shelf guide 1415.

[0352] The crane module 1430 receives power from the fixed horizontal guide 1431, the horizontal movement guide 1433, the grab elevator 1434 and / or the grab 1437.

[0353] Each component that receives power from the lifting module 1410 and the crane module 1430 can perform an operation through the following drive method.

[0354] In one embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can provide a belt-type motion to move the reaction vessel 1500.

[0355] In another embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can provide chain-type motion to move the reaction vessel 1500.

[0356] In another embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can provide a screw-type or jack-screw-type movement to move the reaction vessel 1500. Petition 870260047759, dated 05 / 19 / 2026, page 68 / 317 57 / 143

[0357] In another embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can provide a cylinder-type movement to move the reaction vessel 1500.

[0358] In another embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can provide a type of lifting motion to move the reaction vessel 1500.

[0359] In another embodiment of the present disclosure, the lifting module 1410 and / or the crane module 1430 can move the reaction vessel 1500 through a drive scheme different from the scheme described above.

[0360] As shown in Figure 21, crane module 1430 can move reaction vessel 1500 collected from analytical sample vessel shelf 1416 to be mounted on the automated sealer 1700. The automatic sealer 1700 is a device for automatically sealing the upper surface of reaction vessel 1500.

[0361] The automatic seal 1700 will be described below with reference to Figure 14.

[0362] Figure 14 is a perspective view illustrating an automatic seal according to an embodiment. As shown in Figure 14, an automatic seal 1700 can seal an inlet of a reaction vessel 1500 in which an analytical sample is accommodated and can be implemented by the following embodiment.

[0363] In one embodiment of the present disclosure, the reaction vessel 1500 is a multi-well plate and an analytical sample is received in each of the multi-well plates in which a plurality of wells are formed that have closed lower portions.

[0364] The 1700 automatic sealer can seal the upper surface of the 1500 reaction vessel, which is a multi-well plate, to prevent mixing of the analytical sample and external contamination. Petition 870260047759, dated 05 / 19 / 2026, page 69 / 317 58 / 143

[0365] In another embodiment of the present disclosure, reaction vessel 1500 is a tube-shaped vessel inserted into each well of a multi-well plate. A plurality of connected or individually separated tubes may be inserted into each well of the multi-well plate.

[0366] The 1700 automatic sealer can seal the top surface of at least one 1500 reaction vessel inserted into each well of the multi-well plate to prevent mixing of the analytical sample and external contamination.

[0367] The 1700 self-sealing device can thermally adhere to the injection port of the 1500 reaction vessel using a transparent film. Alternatively, adhesive can be used.

[0368] In one embodiment of the present disclosure, the 1700 automatic sealer may use Hamilton Inc.'s Plate Sealer product (see https: / / www.hamiltoncompany.com / automated-liquid-handling / smalldevices / hamilton-plate-sealer).

[0369] The automatic seal 1700 can be positioned variously inside the housing 1300.

[0370] In one embodiment of the present disclosure, the automatic seal 1700 can be arranged as shown in Figure 30. As shown in Figure 30, the automatic seal 1700 can be located between the first analysis device 1200-a and the second analysis device 1200-b.

[0371] When the automatic seal 1700 is positioned between the first analysis device 1200-a and the second analysis device 1200-b, the reaction vessel 1500 can be rotated horizontally by 90 degrees and mounted on the automatic seal 1700.

[0372] A 90-degree horizontal rotation of reaction vessel 1500 can be performed by the rotation module of gripper 1436 in Figure 12. Petition 870260047759, dated 05 / 19 / 2026, page 70 / 317 59 / 143

[0373] The crane module 1430 horizontally rotates the reaction vessel 1500 by 90 degrees using the gripper rotation module 1436 to mount the reaction vessel 1500 onto the automated sealer 1700.

[0374] In another embodiment of the present disclosure, the automatic seal 1700 can be implemented to be located in other locations within the enclosure 1300.

[0375] In another embodiment of the present disclosure, the automatic seal 1700 can be implemented to be located in the preparation device 1100.

[0376] As shown in Figure 22, crane module 1430 can move reaction vessel 1500 sealed by automatic seal 1700 to be mounted on any one of the plurality of analysis devices 1200-a and 1200-b. Analysis devices 1200-a and 1200-b are devices for automatically analyzing one or more samples contained in reaction vessel 1500.

[0377] The analysis device 1200 according to an embodiment of the present disclosure can be described as follows with reference to Figure 13. Figure 13 is a perspective view illustrating a self-contained analysis device according to an embodiment of the present disclosure. As shown in Figure 13, the analysis device 1200 is a self-contained device. That is, the analysis device 1200 can be installed and operated alone for analysis of the sample.

[0378] The analysis device 1200 is a device for automatically analyzing one or more analytical samples contained in the reaction vessel 1500.

[0379] According to one embodiment of the disclosure, the analysis device 1200 can be operationally connected to the preparation device 1100 and / or to the housing 1300 and used as the automated analysis system 1000.

[0380] The 1200 analysis device may include a nucleic acid amplifier to amplify a nucleic acid and / or an optical module to detect the amplified nucleic acid. Petition 870260047759, dated 05 / 19 / 2026, page 71 / 317 60 / 143

[0381] In one embodiment of the present disclosure, the analysis device 1200 includes a nucleic acid amplifier and an optical module.

[0382] In another embodiment of the present disclosure, the analysis device 1200 includes a nucleic acid amplifier.

[0383] In another embodiment of the present disclosure, the analysis device 1200 includes an optical module.

[0384] In one embodiment of the present disclosure, an analysis device 1200 can be operationally connected and applied to the automated analysis system 1000.

[0385] In another embodiment of the present disclosure, a plurality of analysis devices 1200 can be operationally connected and applied to the automated analysis system 1000.

[0386] A reaction vessel 1500 to receive the analytical sample prepared in the preparation device 1100 can be mounted on the analytical device 1200.

[0387] In one embodiment of the present disclosure, the analysis device 1200 can be assembled with the reaction vessel 1500 whose upper surface is sealed by the automatic seal 1700. For this purpose, the reaction vessel 1500 can be moved from the preparation device 1100 to the automatic seal 1700 and can be assembled onto the analysis device 1200 after the sealing of the upper surface is completed.

[0388] The analysis device 1200 is supplied with a sample holder 1210 in which the reaction vessel 1500 is accommodated.

[0389] The analytical device 1200 can be supplied with a sample holder and a lid 1220 to protect the reaction vessel 1500 housed in the sample holder. The analytical device 1200 is supplied with the lid 1220 open before receiving the reaction vessel 1500. The lid 1220 of the analytical device 1200 is closed after the reaction vessel 1500 is received. Petition 870260047759, dated 05 / 19 / 2026, page 72 / 317 61 / 143

[0390] When the analysis device 1200 operates as a stand-alone device, the cover 1220 can be opened or closed by a user command input.

[0391] When operationally connected to the automated analysis system 1000, the analysis device 1200 can be configured so that the cover 1220 is opened or closed by the control module of the automated analysis system 1000.

[0392] In one embodiment of the present disclosure, the reaction vessel 1500 can be provided in the form of a multi-well amplification plate including a plurality of analysis samples to be analyzed in each of a plurality of wells. In this case, the sample holder can accommodate a multi-well amplification plate. If required, the well plate includes n x m wells (n × m are natural numbers of 2 or more). The well plate can have a rectangular shape in which n x m wells are arranged in rows and columns. For example, 16 wells of 4 by 4 are shown. A well plate with n x m wells can be mounted on the sample holder.

[0393] Several examples of well plates are as follows.

[0394] The well plate may include 4 wells of 2 X 2, 9 wells of 3 X 3, 16 wells of 4 X 4, 25 wells of 5 X 5, 36 wells of 6 X 6, 49 wells of 7 X 7 or 64 wells of 8 X 8, etc. In addition, the well plate may include 8 wells of 2 X 4, 18 wells of 3 X 6, 32 wells of 4 X 8, 50 wells of 5 X 10, 72 wells of 6 X 12, 98 wells of 7 X 14, or 128 wells of 8 X 16 and similar. Furthermore, the well plate may include 12 wells of 2 x 6, 27 wells of 3 x 9, 4 x 12, 48 wells of 5 x 15, 75 wells of 6 x 18, 108 wells of 7 x 21, 147 wells of 8 x 24 or similar. Additionally, the well plate may include 16 wells of 2 x 8, 36 wells of 3 x 12, 64 wells of 4 x 16, 100 wells of 5 x 20, 144 wells of 6 x 24, 196 wells of 7 x 28, or 256 wells of 8 x 32 and... Petition 870260047759, dated 05 / 19 / 2026, page 73 / 317 62 / 143 similar. In addition, the well plate may include 96 wells of 8 x 12, 192 wells of 12 x 16 or 384 wells of 16 x 24, etc.

[0395] In another embodiment of the present disclosure, the reaction vessel may be provided with one or more independent reaction vessels. In this case, the sample holder may receive one or more vessels for each reaction.

[0396] In another embodiment of the present disclosure, the reaction vessel may be provided in the form of a strip tube to which two or more sample containers are connected. In this case, the sample holder may accommodate at least one reaction vessel in the form of a strip tube.

[0397] In one embodiment of the present disclosure, at least one analysis device 1200 that receives the sealed reaction vessel 1500 in the automatic sealer 1700 can be provided in the enclosure 1300. That is, with reference to Figure 4, two analysis devices 1200-a and 1200-b can be provided within the enclosure 1300.

[0398] In one embodiment of the present disclosure, when two analysis devices are provided in the housing 1300, the preparation device 1100 sequentially prepares samples for analysis. When the first reaction vessel is prepared in the preparation device 1100, the first half of the vessel is moved so that any analysis device in the housing 1300 performs the analysis of the first reaction vessel.

[0399] When the second reaction vessel is prepared in preparation device 1100, another analysis device in housing 1300 moves the second reaction vessel to perform the analysis of the second reaction vessel.

[0400] In another embodiment of the present disclosure, when two analytical devices are provided in the housing 1300, the preparation device 1100 simultaneously or sequentially prepares analytical samples for analysis. When the first reaction vessel and the second reaction vessel are prepared in the device of Petition 870260047759, dated 05 / 19 / 2026, page 74 / 317 63 / 143 preparation 1100, each reaction vessel 1500 is moved sequentially to the casing 1300, and when the first reaction vessel is mounted on any analysis device 1200-a, the second reaction vessel is mounted on the other analysis device 1200-b.

[0401] Figure 5 is a perspective view illustrating a self-contained preparation device according to an embodiment of the present disclosure. As shown in Figure 5, the preparation device 1100 is a self-contained device. That is, the preparation device 1100 can be installed and operated independently to prepare the sample for analysis.

[0402] According to an embodiment of the present disclosure, the preparation device 1100 can be operationally connected to the analysis device 1200 and / or to the enclosure 1300 and used as the automated analysis system 1000.

[0403] The 1100 preparation device may include a nucleic acid extraction module and / or a liquid handling module for extracting nucleic acid from the analyte.

[0404] In one embodiment of the present disclosure, the preparation device 1100 includes a nucleic acid extraction module and a liquid handling module.

[0405] In another embodiment of the present disclosure, the preparation device 1100 includes a nucleic acid extraction module.

[0406] In another embodiment of the present disclosure, the preparation device 1100 includes a liquid handling module.

[0407] In the present disclosure, the nucleic acid extraction module and / or the liquid handling module included in the stand-alone preparation device 1100 can be operationally connected to the automated analysis system 1000 without being deformed. Petition 870260047759, dated 05 / 19 / 2026, page 75 / 317 64 / 143

[0408] Furthermore, when the stand-alone preparation device 1100 is operationally connected to the automated analysis system 1000, the preparation device 1100 can use a reagent container in the form of a tube that was previously used.

[0409] In one embodiment of the present disclosure, when the preparation device 1100 is used as the automated analysis system 1000, the first passage cavity 1130 formed in the preparation device 1100 can be used as a defined passage through which the reaction vessel 1500 is transported by the transport device 1400. Therefore, in the present descriptive report, the first passage cavity and the first defined passage can be combined.

[0410] As shown in Figure 5, the first defined pass 1130 is formed on the lower surface of the preparation device 1100, but the first defined pass 1130 can be formed on the side surface (including front, rear, left and right) or it can be formed earlier on the upper surface according to the type of preparation device 1100.

[0411] In another embodiment of the present disclosure, when the preparation device 1100 is used as the automated analysis system 1000, the preparation device 1100 can form a first defined passage 1130, which is a defined passage through which the reaction vessel can be transported by the carrier device 1400.

[0412] The first defined pass of the preparation device 1100 can be formed on any of a top surface, a bottom surface and a side surface (including front / rear / left / right).

[0413] The first defined passage 1130 is formed to have a size that allows the reaction vessel 1500 and the transport device 1400 to transport the reaction vessel to move. Petition 870260047759, dated 05 / 19 / 2026, page 76 / 317 65 / 143

[0414] In one embodiment of the present disclosure, when an analysis device 1200 is provided as the analysis device used in the automated analysis system 1000, the preparation device 1100 can sequentially prepare the analysis samples, one by one, and provide the prepared analysis samples after the analysis is completed on the analysis device 1200.

[0415] In another embodiment of the present disclosure, when two or more analysis devices 1200 are provided for use in the automated analysis system 1000, the preparation device 1100 sequentially prepares each analysis sample to be supplied to each analysis device and supplies the prepared analysis sample to any analysis device. Subsequently, the next analysis sample prepared in the preparation device may be supplied to another analysis device.

[0416] In another embodiment of the present disclosure, when two or more analysis devices 1200 are provided for use in the automated analysis system 1000, the preparation device 1100 prepares each analysis sample to be provided for each analysis device to be equal to or less than the number of analysis devices. Subsequently, a plurality of prepared analysis samples may be provided for each corresponding analysis device.

[0417] The preparation device 1100 includes a platform 1110 that can hold various types of instruments and containers for preparing the analytical sample. The platform 1110 is formed in a shape in which the components included in the preparation device 1100 can be mounted and secured.

[0418] In one embodiment of the present disclosure, the platform 1110 provides a guide for the components of the preparation device 1100 to be inserted into the interior of the preparation device 1100 in a sliding manner and positioned on top of the platform 1110. Petition 870260047759, dated 05 / 19 / 2026, p. 77 / 317 66 / 143

[0419] The guide is a modality of the 1110 platform and may be provided in the form of another modality.

[0420] In one embodiment of the development, one or more components located on the platform 1110 can be fixed during the operation of the preparation device 1100 by projections and / or grooves formed on the underside of each component, etc.

[0421] The preparation device 1100 may include a loading tray 1120 on a plane extending from the platform 1110. The loading tray 1120 is installed to extend from the platform 1110 so that components mounted on the preparation device 1100 can be easily moved to the preparation device 1100. The loading tray 1120 may include a guide that extends from or is connected to the guide of the platform 1110. Components mounted on the preparation device 1100 can be easily moved and mounted by the guide of the platform 1110 and the guide of the loading tray 1120.

[0422] In one embodiment of the present disclosure, the preparation device 1100 is provided with a pipette module (not shown) comprising pipette arms for dispensing liquid and one or more pipetting channels connected to the pipette arms. The pipette module is provided in an upper portion within the preparation device 1100.

[0423] In addition, a transfer module (not shown) for transporting various containers used for sample preparation, including a reaction vessel in preparation device 1100, is provided on one side of the interior of preparation device 1100.

[0424] In another embodiment of the present disclosure, the transfer module is configured on the upper side of the interior of the preparation device 1100 together with the pipette module. Petition 870260047759, dated 05 / 19 / 2026, page 78 / 317 67 / 143

[0425] In another embodiment of the revelation, the transfer module is implemented by a pipetting channel of the pipetting module and a gripper (not shown) coupled to the pipetting channel.

[0426] Each component located on platform 1110 of the preparation device 1100 is positioned in a predetermined location for sample preparation for analysis.

[0427] A first passage cavity 1130 is formed in the platform 1110. The first passage cavity 1130 is a space in which the transport device 1400 to receive the reaction vessel 1500 prepared in the preparation device 1100 is moved. The first passage cavity 1300 is sized to allow the transport device 1400 to move through the receiving reaction vessel 1500.

[0428] In one embodiment of the present disclosure, each component located on the 1110 platform can be described as follows. The components described below are generally included in the 1100 preparation device and used to prepare an analytical sample, but any one or more components may not be included depending on the type of individually operated stand-alone device. Alternatively, it can be used as a separate device.

[0429] All components of the 1100 preparation device are designed as an integrated device. The 1100 preparation device includes a nucleic acid extraction module for extracting nucleic acid from a sample and various components for amplification reaction setup (e.g., PCR setup).

[0430] The interior of the preparation device 1100, according to an embodiment of the present disclosure, may include a pipette tip adapter, a container carrier, a nucleic acid extraction module, an adapter Petition 870260047759, dated 05 / 19 / 2026, page 79 / 317 68 / 143 multi-well plate, a reader, a residual liquid inlet, a transfer module, a pipette module and the like. Figure 38 is a layout diagram illustrating that the components of the preparation device according to an embodiment of the present disclosure are located on the platform.

[0431] 1) A pipette tip adapter holds one or more pipette tips attached to a pipetting channel. The pipette tip can be attached to the pipetting channel to aspirate and dispense a solution, such as a specimen or reagent, contained in the container.

[0432] One or more pipette tips accommodated in the pipette tip adapter can be supplied to have different sizes and dispensing quantities according to a preparation operating environment, such as the size of a container and the volume of a dispensed solution.

[0433] In one embodiment of the present disclosure, the pipette tip adapter of the device may be provided in a plurality to accommodate tips of various capacities, such as 1 ml, 500 μl, 300 μl, 250 μl, 200 μl, 150 μl, 100 μl and / or 50 ml. Additionally, any one or more tips of various capacities may be piercing tips.

[0434] Each pipette tip adapter can receive one or more pipette tips, and the pipette module positions the pipetting channel over the pipette tip adapter and then moves it towards the pipette tip so that the pipetting channel can engage with the pipette tip.

[0435] The number of pipette tip adapters and each capacity and size of a pipette tip accommodated in the pipette tip adapter may be modified or altered in accordance with various embodiments of the present disclosure.

[0436] 2) The container conveyor includes several containers to hold various types of solutions used in the preparation device. The device of Petition 870260047759, dated 05 / 19 / 2026, p. 80 / 317 The 69 / 143 preparation can prepare an analytical sample including extracted nucleic acid using a nucleic acid extraction module. Various types of containers are used for the operation of the preparation device, and the container carrier can be inserted with containers, except for the well plate.

[0437] The container carrier can be supplied in various forms to allow each container to be easily inserted and secured according to the capacity and / or size of the container to be inserted.

[0438] In one embodiment of the present disclosure, the inserted container includes a container to hold the specimen, a container to hold the extraction reagent, and a container to hold the reaction reagent. The container carrier may insert containers in a row or in parallel.

[0439] The container carrier may have a passage cavity on the side to allow the identification code printed on or attached to the container to be exposed. Consequently, the reader located on platform 1110 can recognize the exposed identification code.

[0440] 3) The nucleic acid extraction module automatically performs a detection sample preparation process used to detect a target nucleotide sequence in a preparation device.

[0441] In the present disclosure, the sample preparation process for detection includes a nucleic acid extraction process from a specimen, preparation of a reaction mixture for amplification, and preparation of a detection sample in which the reaction mixture and the extracted nucleic acids are mixed.

[0442] If a nucleic acid extraction module is not included in the preparation device, the sample may be a nucleic acid previously obtained through a nucleic acid extraction process. Petition 870260047759, dated 05 / 19 / 2026, page 81 / 317 70 / 143

[0443] In another embodiment, nucleic acid extraction is often performed by a magnetic bead-based method using magnetic beads that bind to a nucleic acid and have the ability to elute the bound nucleic acid. The automated magnetic bead-based nucleic acid extraction method may use a liquid transfer method or a bead transfer method depending on the type of elution process of the nucleic acid bound to the magnetic bead.

[0444] 4) The multi-well plate adapter is a structure in which a reaction vessel to accommodate a specimen to be detected can be located, and the reaction vessel can be mounted on a sample holder of an analytical device.

[0445] The multi-well plate adapter can hold a reaction vessel (multi-well plate) and a sample for detection can be dispensed into the reaction vessel (multi-well plate) positioned in the multi-well plate adapter. In the multi-well plate adapter, two or more multi-well plates used in the preparation device can be stacked. In one embodiment of the present disclosure, the term “multi-well plate” can be used to refer to a reaction vessel adapter.

[0446] At this point, any of the plurality of multi-well plates supplied in the multi-well plate adapter can be moved to the starting position and used in an operation to prepare an analytical sample. The multi-well plate is moved to the starting position by the transfer module.

[0447] 5) Several containers can be mounted directly onto the mounting structure or via an adapter or similar. The container can hold an analytical sample or extraction reagent. The container is equipped with a cap that can be pierced by the tip of a pipette. The penetrating portion of the cap can be made of a material such as silver rubber, silicon, plastic, or similar. Petition 870260047759, dated 05 / 19 / 2026, p. 82 / 317 71 / 143

[0448] The pipette tip pierces the top of the cap in a downward motion, draws up or dispenses the solution, and then moves upward again. When the pipette tip moves upward from the container, the container needs to be secured because the container can be lifted along with it by the pipette tip inserted into the perforated part of the cap. The securing structure can fix the container so that the container with the pierceable cap is not moved by the pipette tip.

[0449] 6) The first passage cavity 1130 is a defined passage through which the transport device 1400 is transported to the preparation device 1100 to receive the reaction vessel 1500.

[0450] In one embodiment of the present disclosure, the first passage cavity 1130 is an empty space. The transport device 1400 is moved from a lower portion of the preparation device 1100 to the interior of the preparation device 1100. Therefore, the first passage cavity 1130, which is an empty space, can be formed on the platform 1110, which is the lower surface of the preparation device 1100, or it can be formed.

[0451] In another embodiment of the present disclosure, the first passage cavity 1130 includes an open / close module (not shown). The open / close module is provided to lock an open space which is the first passage cavity 1130, into which the transport device 1400 enters. The transport device 1400 is moved to the preparation device 1100 to receive the reaction vessel prepared in the preparation device 1100. The preparation device 1100 can lock the first passage cavity 1130 using an open / close module to close the open space at a time when the transport device 1400 is not moving.

[0452] 7) The residual portion comprises a residual liquid inlet and / or a residual pipette tip collection unit. The solution inlet Petition 870260047759, dated 05 / 19 / 2026, page 83 / 317 72 / 143 recovery can be collected so that the solution used for sample preparation is discarded, and recovery from the pipette tip can be collected so that the pipette tip used for sample preparation is discarded.

[0453] In one embodiment of the present disclosure, the residual liquid inlet is connected to a separately positioned liquid waste collection compartment (not shown). The waste solution from the preparation device 1100 is moved to be accommodated in the liquid waste collection compartment through the recovery solution inlet.

[0454] In addition, the pipette tip collected through the waste pipette tip collection unit can be moved to the waste container and stored. In one embodiment of the present disclosure, the waste container may be located on platform 1110 of the preparation device 1100. In another embodiment of the present disclosure, the waste container may be located on the lower surface of the preparation device 1100. In yet another embodiment of the present disclosure, the waste container may be located outside the preparation device 1100.

[0455] When the waste container is located on platform 1110, the waste container can be separated into an area where the analysis sample is prepared, a partition, and similar.

[0456] 8) The transfer module is a mechanical device in the form of a gripper for moving the reaction vessel or similar in the preparation device 1100. The transfer module is operated by a control device of the preparation device 1100.

[0457] In one embodiment of the present disclosure, the transfer module is located on the inner rear of the 1100 preparation device. The module Petition 870260047759, dated 05 / 19 / 2026, page 84 / 317 The 73 / 143 transfer mechanism is configured to move the reaction vessel up and down, left and right, forward and backward, and to rotate.

[0458] In another embodiment of the present disclosure, the transfer module is located in an internal upper portion of the preparation device 1100. The transfer module is configured to move the reaction vessel up and down, left and right, forward and backward, and rotate through a type of operation, like a pipette module.

[0459] In another embodiment of the present disclosure, the transfer module is configured to move the reaction vessel up and down, left and right, forward and backward, and to rotate using a gripper coupled to at least two pipetting channels of the pipetting module's pipetting channels.

[0460] The transfer module can move components needed for sample preparation for analysis, such as a reaction vessel, a reagent container, an adapter, a cartridge, a multi-well plate and the like within the 1100 preparation device.

[0461] In one embodiment of the present disclosure, the transfer module can move the reaction vessel in which the analytical sample setup is completed to the transport device 1400. The transport device 1400 is moved through the first passage cavity 1130 of the preparation device 1100 to receive a reaction vessel whose preparation is completed. The transfer module can move the reaction vessel to the transport device 1400 and the transport device 1400 can move the reaction vessel to the outside of the preparation device 1100 through the first passage cavity 1130.

[0462] 9) The reader can read an identification code displayed on a specimen, reagent, reaction mixture, etc. The identification code is a display that includes information such as a barcode and a matrix code. The reader can Petition 870260047759, dated 05 / 19 / 2026, page 85 / 317 74 / 143 recognize the identification code to receive information, such as the type and capacity of the solution contained in the container.

[0463] In one embodiment of the present disclosure, a plurality of readers may be provided and may consist of any reader as required. Additionally, the reader may be configured as a barcode reader and / or a 2D reader. It is preferable that such a configuration be provided for the purpose of having the capability to recognize different types of identification codes marked on a reaction vessel or similar.

[0464] In a disclosure implementation, the reader can recognize 1D and / or 2D barcodes. The reader can recognize an identification code printed on or affixed to the side of the container to obtain information such as the type and / or capacity of the solution contained in the container. The container includes a reaction vessel, a reagent container, and a specimen container used in a preparation device. The reader can recognize the container identification code inserted into the 1110 platform. The reader can sequentially recognize at least one container identification code inserted into the 1110 platform. The reader can move to a position where the container or the carrier receiving the container is attached to the 1110 platform to recognize the container-side identification code.

[0465] In another implementation of the disclosure, the reader is a 2D barcode reader (not shown). Matrix (two-dimensional) codes can be recognized, and identification codes printed or affixed to the bottom surface of the container can be recognized. The container includes a container used in a preparation device, such as a reaction vessel, a reagent container, and a specimen container.

[0466] Consequently, when a plate formed to have a passage cavity in all or part of the lower surface of each well is mounted on Petition 870260047759, dated 05 / 19 / 2026, p. 86 / 317 75 / 143 reader, the reader can recognize an identification code printed or affixed to the underside of the container inserted into the plate. The reader can recognize the codes of multiple containers inserted into the plate at once.

[0467] In one embodiment of the present disclosure, the plane on which the container is mounted in the reader is made of a transparent material. The reader can recognize the identification code on the bottom of the container using an optical signal transmitted through a transparent material. In addition, the reader can recognize the container's identification code by photographing the bottom of the container. The reader has a form in which the multi-well plate can be mounted so that the identification code located on the bottom surface of the container inserted into the multi-well plate can be recognized.

[0468] The 2D reader according to an embodiment of the present disclosure may use Hamilton's easyCode Carrier product (see https: / / www.hamiltoncompany.com / automated-liquid-handling / smalldevices / easycode-carrier).

[0469] 10) Although not shown in the figures, the pipette module is positioned in an internal upper portion of the preparation device 1100. A pipette module, which is a solution fractionator, includes a pipette arm and a pipetting channel, and the pipetting channel can be moved automatically up and down, left and right, and forward and backward by a control device.

[0470] The pipette arm may include one or more pipetting channels that move independently or dependently. In one embodiment, a pipette tip or needle is attached to the end of the pipetting channel and may be used to aspirate and dispense the solution.

[0471] In another embodiment, a clamp can be attached to one end of the pipetting channel and can be used as a module for Petition 870260047759, dated 05 / 19 / 2026, page 87 / 317 76 / 143 transfer that has the capacity to move a vessel (including a reaction vessel) or similar, used in the preparation device 1100 for the reaction vessel or similar by the gripper.

[0472] The pipette arm can perform an operation of moving one or more pipetting channels to a fractionating pipette tip, an operation of fixing the fractionating pipette tip to the pipetting channel, an operation of moving the pipetting tip in which the pipetting channel is fixed to a predetermined place, an operation of inserting the fractionating pipette tip into a container at a predetermined depth, or similar operations.

[0473] The pipette arm is placed inside the preparation device 1100 and the pipetting channel is operated inside the preparation device 1100 by the pipette arm. One or more pipetting channels couple the pipette tip inserted in the pipette tip adapter to one end of the pipetting channel.

[0474] The pipette arm can move the pipetting channel to be located above the container in which the solution to be dispensed is contained. The pipetting channel is lowered towards the container in the moved position to accommodate the solution at the pipette tip and is positioned to rise again. The pipetting channel can complete the dispensing by moving to the top of another container to be dispensed by the pipette arm, and lowering to dispense the solution received at the pipette tip and then rising again.

[0475] Multiple pipetting channels can be operated simultaneously and the number of containers that can be dispensed simultaneously can be determined according to the number of pipetting channels.

[0476] The pipette arm and pipetting channel can remove the pipette tip attached to the end after dispensing is complete. Pipette tips Petition 870260047759, dated 05 / 19 / 2026, page 88 / 317 77 / 143 glued pipette tip collection points are removed from the residual pipette tip collection unit located in the waste unit and can be discarded in the waste container.

[0477] In one embodiment of the present disclosure, each device must be positioned precisely so that at least one of the preparation device 1100, the analysis device 1200 and / or the transport device 1400 is operationally connected to the enclosure 1300. For this purpose, the enclosure 1300 and each device include a positioning means.

[0478] Since the preparation device 1100, the analysis device 1200 and / or the transport device 1400 must not be externally deformed and must be coupled to the housing 1300, it is preferable that the positioning means of each device use a component previously formed in each device. This is described with reference to Figures 32 to 34.

[0479] Figure 32 is an exemplary diagram illustrating that an analysis device is mounted in an enclosure using a positioning means according to an embodiment of the present disclosure. Figure 33 is a first exemplary diagram illustrating a positioning means according to an embodiment of the present disclosure. Figure 34 is a second exemplary diagram illustrating a positioning means according to an embodiment of the present disclosure. As shown in Figures 32 to 34, at least one of the preparation device 1100, the analysis device 1200 and / or the transport device 1400 is spatially enclosed and the enclosure 1300 is used as a configuration for spatial closure.

[0480] At least one of the preparation device 1100, the analysis device 1200 and / or the transport device 1400 is configured to be positioned within the enclosure 1300 in order to operationally connect at least one or more. Petition 870260047759, dated 05 / 19 / 2026, page 89 / 317 78 / 143

[0481] Figure 32 shows that the analysis device 1200-a, 1200-b is located in an enclosure 1300 according to an embodiment of the present disclosure. In this case, in the analysis devices 1200-a and 1200-b, the reaction vessel 1500 in which the analysis sample is accommodated in the preparation device 1100 located outside the enclosure 1300 can be moved through the transport device 1400.

[0482] In particular, the crane module 1430 of the transport device 1400 provides the reaction vessel 1500 for the analysis devices 1200-ae 1200-b. The crane module 1430 can move to a projected position as a robotic module to lift the reaction vessel 1500 and can place the reaction vessel 1500 in a projected location.

[0483] If the positions of the analysis devices 1200-a and 1200-b deviate from the predetermined position, even slightly, the reaction vessel 1500 will not be positioned precisely and, therefore, a proper analysis cannot be performed. Thus, the analysis devices 1200-a and 1200-b must be positioned or coupled precisely in a predetermined location within the enclosure 1300. For this purpose, the enclosure 1300 provides a means of positioning.

[0484] As shown in Figures 33 and 34, the positioning means may be located in the analysis device 1200 and in the housing 1300.

[0485] In one embodiment of the present disclosure, the first positioning means 1230 of the analysis device 1200 may be a fixing means located in the lower portion. Furthermore, the second positioning means 1390 of the housing 1300 may be a structure formed in a place where the analysis device 1200 is located. Petition 870260047759, dated 05 / 19 / 2026, page 90 / 317 79 / 143

[0486] The first positioning means 1230 and the second positioning means 1390 can be formed in a format that has the capacity to be coupled together.

[0487] According to one embodiment of the present disclosure, even if the first positioning means 1230 and the second positioning means 1390 do not have separate gripping means, the analysis device 1200 can be fixed in a precise position of the housing 1300.

[0488] According to another embodiment of the present disclosure, the first positioning means 1230 and the second positioning means 1390 are provided with mutual gripping means (not shown) for attaching the respective positioning means to the gripping means when the analysis device 1200 is fixed to the correct position of the housing 1300.

[0489] Although Figures 32 to 34 illustrate the positioning means between the analysis device 1200 and the housing 1300, it is preferred that a positioning means corresponding to the housing be formed in each device located within the housing 1300, such as the transport device 1400 and the automatic seal 1700 according to an embodiment of the present disclosure.

[0490] Figure 39 is a flowchart illustrating an operational method of the automated analysis system according to an embodiment of the present disclosure. As shown in Figure 39, the automated analysis system of the present disclosure consists of an enclosure that includes a preparation device, an analysis device, and / or a transport device. Each preparation device and analysis device included in the automated analysis system can be operated as a stand-alone device.

[0491] The automated analysis system can position at least one selected device from the group consisting of a device of Petition 870260047759, dated 05 / 19 / 2026, page 91 / 317 80 / 143 preparation, an analysis device and a transport device inside the space enclosure.

[0492] As in an embodiment of the present disclosure, the automated analysis system is configured so that an analysis device is provided within an enclosure and a preparation device is positioned in the enclosure.

[0493] The automated analysis system includes a control module. The control module controls the preparation device to prepare an analysis sample. The control module controls the container to analyze the prepared analysis sample.

[0494] A method in which the control module of the automated analysis system controls the preparation device and the housing to prepare and analyze the sample is as follows.

[0495] The control module controls the preparation device so that an analytical sample is prepared in the reaction vessel provided in the preparation device (S110).

[0496] The preparation device prepares a solution, such as a specimen, a nucleic acid extraction reagent, an amplification reaction reagent and the like, for the purpose of preparing an analytical sample and prepares the analytical sample using internal components.

[0497] In step S110, a preparation device can be used as a control module to prepare an analytical sample.

[0498] The preparation device can perform at least one of the following preparations: preparing the sample for analysis by performing a split of at least one of a specimen and a reagent; receiving the sample for analysis into the reaction vessel; or extracting nucleic acid from the specimen that is expected to contain a pathogen. Petition 870260047759, dated 05 / 19 / 2026, page 92 / 317 81 / 143

[0499] The control module controls the lifting module in the enclosure so that the reaction vessel prepared in the preparation device is moved into the enclosure (S120).

[0500] In step S120, the lifting module moves into the preparation device through the second passage cavity formed in the casing and the first passage cavity formed in the preparation device platform. The preparation device mounts the reaction vessel onto the moved lifting module.

[0501] When the reaction vessel is mounted on the lifting module, the control module controls the lifting module to move into the enclosure.

[0502] The first passage cavity is a defined passage through which the reaction vessel can be transported.

[0503] In one embodiment of the present disclosure, the enclosure may include a plurality of analysis devices for analyzing an analysis sample.

[0504] The control module controls the preparation device so that the samples to be analyzed can be prepared simultaneously or sequentially using a plurality of analysis devices.

[0505] The control module controls the lifting module so that the lifting module can move the reaction vessel that holds the sample for analysis that is prepared simultaneously or sequentially in the preparation device into the housing.

[0506] In step S120, when the lifting module is moved to the preparation device to receive the reaction vessel, the control module controls the lifting module to perform an extension movement in the horizontal direction to easily receive the reaction vessel. Petition 870260047759, dated 05 / 19 / 2026, page 93 / 317 82 / 143

[0507] The control module controls the crane module so that the reaction vessel moved into the enclosure is moved to the position where the analysis is performed (S130).

[0508] The crane module can perform a movement operation to move the reaction vessel moved to the enclosure in the up and down, left and right, and forward and backward directions. The crane module can perform a rotation operation to horizontally rotate the reaction vessel.

[0509] In one embodiment of the present disclosure, the automatic seal is included within the housing.

[0510] When the automatic seal is provided in the enclosure, the control module controls the crane module to move the reaction vessel from the preparation device to the automatic seal. The automatic seal can seal the top surface of the reaction vessel.

[0511] The control module controls the crane module so that the sealed reaction vessel in the automatic seal is moved to a position where the analysis of the analysis sample is performed. A location where the analysis is performed is an analysis device.

[0512] In another embodiment of the present disclosure, the automatic seal may be included in the preparation device.

[0513] When an automatic seal is provided in the preparation device, the control module moves a prepared reaction vessel in the preparation device to the automatic seal. The control module controls the automatic seal to seal the top surface of the moved reaction vessel.

[0514] When the automatic sealer is provided in the preparation device, in step S120, the lifting module can receive a reaction vessel in which the sealing is completed. Petition 870260047759, dated 05 / 19 / 2026, page 94 / 317 83 / 143

[0515] In one embodiment of the present disclosure, when a plurality of analysis devices is provided and a plurality of reaction vessels is received sequentially in the preparation device, the control module controls the crane module to move each of the sequentially moved analysis sample vessels to the analysis device.

[0516] The control module controls the enclosure so that the analysis sample housed in the reaction vessel of the enclosure is analyzed (S140).

[0517] In step S140, the reaction vessel can be moved to the analysis device by the crane module. The analysis device analyzes a sample from the moved reaction vessel and generates a result.

[0518] In step S140, the enclosure in which the control module controls the enclosure so that the analysis of the analysis sample is performed is an analysis device.

[0519] The analysis device can perform at least one of a process of carrying out a polymerase chain reaction and a process of carrying out analysis on a reaction result.

[0520] The analysis device is supplied in the position where the analysis is performed.

[0521] The analytical device includes a thermocycler and an optical module. A process for carrying out the polymerase chain reaction in the analytical device uses a thermocycler, and a process for measuring the result of a reaction uses an optical module.

[0522] The analysis device may be provided with a cover for analyzing the sample. The control module may provide a control signal to the analysis device so that a cover of the analysis device is opened, to which the reaction vessel will be moved. Subsequently, when the crane module provides the reaction vessel to the analysis device, Petition 870260047759, dated 05 / 19 / 2026, page 95 / 317 The 84 / 143 control module can provide a control signal to close the lid of the analysis device.

[0523] The control module controls the crane module to remove the reaction vessel whose analysis is completed from the position where the analysis is performed (S150).

[0524] In step S150, the control module controls the crane module so that the reaction vessel whose analysis has been completed can be moved to a reaction vessel recovery container.

[0525] According to one aspect of the present disclosure, the present disclosure provides an automated analysis system including a memory, at least one processor configured to access the memory, and one or more programs stored in memory and configured to be executed by the processor. The automated analysis system includes a preparation device, an analysis device, a transport device, a control module, and an enclosure, wherein one or more programs include instructions that, when executed by one or more processors, cause one or more programs to perform the following steps: the control module controls the transport device to transport a reaction vessel containing an analysis sample from the preparation device to the analysis device; wherein the preparation device and the analysis device are self-contained devices;The control module controls the analysis device to analyze the sample in the analysis device; the control module controls the transport device to remove the reaction vessel from which the analysis of the sample is completed from the analysis device; at least one device selected from the group consisting of the analysis device and the transport device is located within an enclosure, wherein the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, in which one or more programs include; Petition 870260047759, dated 05 / 19 / 2026, page 96 / 317 85 / 143 instructions that cause the transport device to carry out the transport of the reaction vessel through the defined passage.

[0526] Each component described in the exemplary embodiment of the present disclosure is the same as the automated analysis system described in Figures 1 to 39 and, therefore, a description thereof will be omitted.

[0527] According to one aspect of the present disclosure, a non-transient, computer-readable storage medium is provided that has instructions which, when executed by one or more processors, cause the automated analysis system to perform an analysis method using an automated analysis system, wherein the automated analysis system includes a preparation device, an analysis device, a transport device, a control module and an enclosure, wherein the instructions include instructions that cause the control module to control the transport device to transport a reaction vessel containing an analysis sample from the preparation device to the analysis device, wherein the preparation device and the analysis device are autonomous devices,wherein the control module controls the analysis device to analyze the sample in the analysis device and wherein the control module controls the transport device to remove the reaction vessel from the analysis device after the analysis of the sample is completed, at least one device selected from the group consisting of the analysis device and the transport device located within an enclosure, wherein the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, and the instructions cause the transport device to perform the transport of the reaction vessel through the defined passage. Petition 870260047759, dated 05 / 19 / 2026, page 97 / 317 86 / 143

[0528] Each component described in the exemplary embodiment of the present disclosure is the same as the automated analysis system described in Figures 1 to 39 and, therefore, a description thereof will be omitted. FAN MODULE CONTROL AND SIGNAL TRANSMISSION

[0529] An RT-PCR device is placed within the automated analysis system, and heat is generated in the RT-PCR device during operation, and the heat needs to be discharged from the interior of the automated analysis system. Consequently, a technology for discharging heat from the automated analysis system, for example, a temperature control technology, is also included in the present problem.

[0530] Furthermore, when the temperature control technology described above is performed, if the target nucleic acid in the sample floats in the air in the automated analysis system described above, another sample may be contaminated due to the flotation. Consequently, a technique to prevent contamination between samples when performing such a temperature control technique is also included in the present subject.

[0531] An automated analysis system according to an embodiment includes: a preparation device for preparing an analysis sample in a reaction vessel; an analysis device for analyzing the prepared analysis sample in the reaction vessel; a transport device for transporting the reaction vessel; an enclosure; a door part for opening and closing the defined passage; a control module; and a fan-operated module for discharging air from an internal space of the enclosure, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure, and each of the preparation device and the enclosure includes a defined passage through which the reaction vessel is transported. Petition 870260047759, dated 05 / 19 / 2026, page 98 / 317 87 / 143

[0532] The control module may include a control unit and a storage unit.

[0533] The defined passage can be opened while the transport device passes through the defined passage.

[0534] In addition, the defined passage can be opened while the transport device is located in the preparation device.

[0535] The automated analysis system may additionally include a transport device configured to receive a predetermined unsealed reaction vessel from the preparation device and transport the vessel to the analysis device, wherein the control unit may operate or stop the fan module according to a position or direction of movement of the transport device.

[0536] In addition, the control unit can interrupt the operation of the fan module while the transport device passes through the defined passage.

[0537] The control unit can interrupt the operation of the fan module while the transport device is located in the preparation device.

[0538] In addition, the control unit can stop the operation of the fan module when the transport device in the internal space starts moving towards the defined passage.

[0539] The control unit can interrupt the operation of the fan module while the transport device is moving towards the analysis device.

[0540] In addition, the control unit can resume operation of the ventilator module after the transport device has arrived at the analysis device and has completed delivery of the container to the analysis device. Petition 870260047759, dated 05 / 19 / 2026, page 99 / 317 88 / 143

[0541] Additionally, the automated analysis system may further include an automatic sealer that performs a sealing operation on the unsealed container, wherein the transport device may receive the unsealed container from the preparation device and transport the unsealed container to the automatic sealer and receive the container in which the sealing operation is completed from the automatic sealer and transport the container to the analysis device, and the period in which the control unit interrupts the operation of the fan module may include a period from the moment the transport device receives the unsealed container from the preparation device until when the transport device transports the container in which the sealing operation is completed to the analysis device.

[0542] The automated analysis system may additionally include a plurality of fan modules, the automated analysis system may additionally include a temperature measurement unit configured to measure an internal space temperature, and the control unit may operate only some of the plurality of fan modules when the temperature measured by the temperature measurement unit is equal to or less than a predetermined temperature, stop the remaining fan modules and operate all the plurality of fan modules when the measured temperature exceeds the predetermined temperature.

[0543] The automated analysis system may additionally include a temperature measurement unit configured to measure an internal space temperature, and the control unit may control the rotation speed of a fan included in the fan module according to the temperature measured by the temperature measurement unit when the fan module is operating.

[0544] The preparation device may include a preparation device management unit configured to manage the Petition 870260047759, dated 05 / 19 / 2026, page 100 / 317 89 / 143 Performance of preparation work and the analysis device may include an analysis device management unit configured to control the performance of the detection work.

[0545] According to an embodiment of the present disclosure, a method for controlling a fan module implemented in an automated analysis system includes: a preparation device for preparing an analysis sample in a reaction vessel; an analysis device for analyzing the prepared analysis sample in the reaction vessel; a transport device for transporting the reaction vessel; an enclosure; a door part for opening and closing a defined passage; and an operated fan module for discharging air from an internal space of the enclosure, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure, wherein the preparation device and the enclosure each include a defined passage through which the reaction vessel is transported, and wherein the method for controlling the fan module includes: a step for opening the defined passage by the door part;and a step to interrupt a fan module operation while the defined passage is open through the door section.

[0546] In the opening stage, the defined passage can be opened while the transport device passes through the defined passage.

[0547] Furthermore, during the opening stage, while the transport device is located in the preparation device, the defined passage can be opened.

[0548] The automated analysis system may additionally include a transport device configured to receive a predetermined unsealed reaction vessel from the preparation device and transport the vessel to the analysis device, wherein the interruption step may include operating or interrupting the fan module according to a position or direction of movement of the transport device. Petition 870260047759, dated 05 / 19 / 2026, page 101 / 317 90 / 143

[0549] Furthermore, in the interruption stage, the operation of the fan module can be interrupted while the transport device passes through the defined passage.

[0550] The interruption step may include interrupting an operation of the fan module while the transport device is located in the staging device.

[0551] In the interruption stage, when the transport device in the internal space begins to move towards the defined passage, the operation of the fan module can be interrupted.

[0552] In the interruption step, the operation of the fan module can be interrupted while the transport device is moved to the analysis device.

[0553] The method may additionally include resuming operation of the ventilator module after the transport device completes delivery of the container to the analysis device after arrival at the analysis device.

[0554] Additionally, the automated analysis system may further include an automatic seal that performs a sealing operation on the unsealed container, wherein the transport device may receive the unsealed container from the preparation device and transport the unsealed container to the automatic seal and receive the container in which the sealing operation is completed from the automatic seal and transport the container to the analysis device, and the period in which the operation of the fan module is interrupted may include a period from a moment when the transport device receives the unsealed container from the preparation device until a moment when the transport device transports the container in which the sealing operation is completed to the analysis device. Petition 870260047759, dated 05 / 19 / 2026, p. 102 / 317 91 / 143

[0555] The automated analysis system may additionally include a plurality of fan modules, the automated analysis system may additionally include a temperature measurement unit configured to measure an internal space temperature, and the method of controlling the fan module may operate only some of the plurality of fan modules and stop the remaining fan modules when the temperature measured by the temperature measurement unit is equal to or less than a predetermined temperature and operate all the plurality of fan modules when the measured temperature is greater than the predetermined temperature.

[0556] The method may additionally include: measuring the temperature of the internal space; and when the fan module is operating, controlling the rotational speed of a fan included in the fan module according to the temperature measured by the temperature measuring unit.

[0557] According to one embodiment, a computer-readable recording medium includes a computer program, and the computer program can be programmed to perform each step included in the method described above.

[0558] A computer program according to an embodiment may be stored in a computer-readable record medium and the computer program may be programmed to include each step included in the method described above.

[0559] According to one embodiment of the method for controlling a pen module of the present disclosure, the risk of pathogens that may be included in the reaction vessel leaking out and dispersing into the air by the operation of the fan module can be reduced.

[0560] Furthermore, the possibility of mixing air within a preparation device to perform the preparation for detecting acid can be reduced. Petition 870260047759, dated 05 / 19 / 2026, page 103 / 317 92 / 143 target nucleic acid and the air around an analysis device to perform target nucleic acid detection.

[0561] Figure 40 is a block diagram that conceptually illustrates a configuration of an automated analysis system 2000 according to one embodiment. With reference to Figure 40, the automated analysis system 2000 includes a preparation device 2100, an analysis device 2200, a transport device 2300, an automatic sealer 2400, a control module 2500, a fan module 2600, and a container processing module 2800. However, the block diagram illustrated in Figure 40 is merely illustrative.

[0562] Here, the preparation device 2100 and the analysis device 2200 can be autonomous devices, that is, devices in stand-alone form. Additionally, each of the devices 2100 and 2200 includes an application programming interface (API). The API can be used to control or monitor each of the devices 2100 and 2200 from the outside, or it can be used by each of the devices 2100 and 2200 to monitor the external situation or to control or monitor the external device.

[0563] Here, since these 2100 and 2200 devices are diagnostic or examination equipment, they can only be used when a license is obtained in a specific country. Furthermore, even after a license has been obtained, if a main function, structure or similar is changed or a feature is added, a situation may arise where a new license needs to be obtained.

[0564] In this regard, since the API corresponds to a core function of the 2100 and 2200 devices, when the API is changed or added, a situation may arise where a license needs to be obtained again.

[0565] In the meantime, the automated analysis system 2000 includes not only the preparation device 2100 and the analysis device 2200 in the form Petition 870260047759, dated 05 / 19 / 2026, page 104 / 317 93 / 143 autonomous device described above, but also a transport device 2300, an automatic sealer 2400, a control module 2500, a fan module 2600 and a container processing module 2800 for transporting or processing a reaction vessel or transmitting and receiving data between them. Furthermore, the device 2100, 2200 or 2300 and the modules 2400 to 2600 and 2800 can be coupled together through assembly and thus a molecular diagnostic system can be completed, and an automated analysis system according to an embodiment can be referred to as an assembly type.

[0566] In the meantime, according to one embodiment, the automated analysis system 2000 may additionally include a configuration not illustrated in Figure 40 or may not include at least one of the configurations illustrated in Figure 40. Furthermore, each configuration of the automated analysis system 2000 may be connected differently from that shown in Figure 40. Hereafter in this document, each configuration will be described in detail.

[0567] Firstly, the 2100 preparation device is used in a sample preparation operation for analysis. In this respect, the 2100 preparation device can be referred to as a sample preparation device.

[0568] The sample preparation for analysis performed by the 2100 preparation device includes, but is not limited to, a nucleic acid extraction operation and a reaction mixture preparation operation for nucleic acid amplification. For example, a nucleic acid extraction operation may not be included in the sample preparation operation performed by the 2100 preparation device according to one embodiment. In that case, the nucleic acid extraction operation described above may be performed by another configuration not shown in Figure 40, instead of the 2100 preparation device. However, the following description will be made on the assumption that the work Petition 870260047759, dated 05 / 19 / 2026, page 105 / 317 94 / 143 nucleic acid extraction is included in the sample preparation work for analysis performed by the 2100 preparation device.

[0569] In the meantime, since the nucleic acid extraction operation described above and the operation for preparing the reaction mixture are known in the art, a detailed description of them will be omitted.

[0570] With reference to Figure 40, the 2100 preparation device includes a 2110 preparation device hardware (HW) unit and a 2120 preparation device management unit.

[0571] Here, the 2110 preparation device HW unit refers to a physically implemented piece of equipment or structure. Furthermore, the 2120 preparation device management unit can generate a command to trigger the 2110 preparation device HW unit, trigger the 2110 preparation device HW unit based on the generated command, output various messages or information as a result of triggering, such as a log, and provide a predetermined application programming interface (API). The 2110 preparation device HW unit and the 2120 preparation device management unit itself will be described below with reference to Figures 41 and 42.

[0572] Figure 41 is a block diagram that conceptually illustrates a configuration of the HW unit of preparation device 2110 of preparation device 2100. However, Figure 41 is merely illustrative.

[0573] With reference to Figure 41, the HW unit of preparation device 2110 of preparation device 2100 includes a pipette module 2111 and a transfer module 2112. In addition, according to one embodiment, preparation device 2100 may further include a nucleic acid extraction module for extracting nucleic acids. Petition 870260047759, dated 05 / 19 / 2026, page 106 / 317 95 / 143

[0574] The 2111 pipette module is a module used in the nucleic acid extraction operation described above and in the reaction mixture preparation operation for nucleic acid amplification. The 2111 pipette module may include a pipette tip and an arm for moving the pipette tip. The 2111 pipette module may be referred to as a liquid handler.

[0575] This 2111 pipette module can automatically or programmatically aspirate and / or dispense a desired quantity of reagent, analytical sample, or other liquid from a container designed for automation in a chemical or biochemical laboratory.

[0576] Transfer module 2112 transfers the reaction vessel to transport device 2300. An analytical sample can be accommodated in the reaction vessel transported by transfer module 2112. The analytical sample accommodated in the reaction vessel can be one in which each of the nucleic acid extraction operations described above and the preparation operation described above for the reaction mixture is completed.

[0577] In the meantime, the transfer module 2112 described above can grasp or position the reaction vessel and can also move while grasping the reaction vessel. In this respect, the transfer module 2112 can be referred to as a gripper.

[0578] Although not shown in Figure 41, the pipette module 2111, the transfer module 2112, or the nucleic acid extraction module may be disposed of in an enclosure with a space therein. That is, the HW part of preparation device 2110 may include the enclosure described above as a configuration. If the nucleic acid extraction operation described above or the reaction mixture preparation operation described above is performed in the enclosure of preparation device 2100, various substances, for example, pathogens that may be included in the sample may leak into a space. Petition 870260047759, dated 05 / 19 / 2026, page 107 / 317 96 / 143 supplied in the enclosure and therefore may float in the space provided in the enclosure. Consequently, according to one embodiment, a technology for reducing this risk is presented which will be described later.

[0579] Here, each configuration illustrated in Figure 41 is already known in the art, and a drawing of each structure and a detailed description related to it will be omitted.

[0580] Figure 42 below is a block diagram that conceptually illustrates the configuration of the 2120 preparation device management unit of the 2100 preparation device. However, Figure 42 is for illustrative purposes only.

[0581] With reference to Figure 42, the preparation device management unit 2120 of the preparation device 2100 includes a command generation unit 2121, an API unit 2122, a register output unit 2123, and a file generation unit 2124. Here, the preparation device management unit 2120 and each of the configurations 2121 to 2124 included therein can be implemented by a processor and memory including instructions executable by the processor.

[0582] Here, the command generation unit 2121 is configured to generate a control command to control each of the configurations 2111 and 2112 shown in Figure 41. The preparation device HW unit 2110 shown in Figure 41 can be activated based on the generated control command.

[0583] The API unit 2122 is configured to provide a predetermined API. In some cases, the staging device 2100 can monitor or control an external object using an API provided by the API unit 2122. Conversely, the external object can monitor or control the staging device 2100 through the use of the API provided by the API unit 2122. Petition 870260047759, dated 05 / 19 / 2026, page 108 / 317 97 / 143

[0584] In one embodiment, the API provided by API unit 2122 does not support a function for accessing the analysis device 2200, which will be described below. However, the API does support a function for generating a file with a specific filename and a function for saving the generated file to a predetermined location. In this case, the file may include predetermined content. Here, “content” includes, but is not limited to, text, an image, a voice, or similar, which is saved to a file. Furthermore, an example of the predetermined location could be a file storage unit that constitutes the control module 2500, which will be described later, and the location could be a location that was previously queried with the analysis device 2200.

[0585] The output register unit 2123 is configured to output a status of the preparation device 2100 and other various information as a register. Examples of the output register may include status information indicating whether the preparation device 2100 is operating normally, operating abnormally, or is interrupted, a command to call the transport device 2300, a command to transport the reaction vessel to the transport device 2300, and the like, but not limited to.

[0586] File generator 2124 is configured to generate a file. The file includes an instruction to which the analysis device 2200 refers when performing a detection operation on a target nucleic acid molecule.

[0587] The instructions include, for example, at least one piece of information about a plate on which a plurality of wells is provided, information about a specimen included in each of the plurality of wells, information about a reagent included in each of the plurality of wells, information about an optical scanning method performed during the detection operation, and a reaction condition during the detection operation, but without Petition 870260047759, dated 05 / 19 / 2026, page 109 / 317 98 / 143 limitation to that. Here, the "reaction condition" could be, for example, a PCR protocol, but without limitation to that.

[0588] When the file generation unit 2124 generates the file described above, a preparation operation for a target nucleic acid molecule performed by the preparation device 2100 can be used as a basis. That is, the content of the instructions described above can be determined according to which plate the pipette module 2111 of the preparation device 2100 performs a preparation operation on, whose specimen is included in each of a plurality of wells included in the corresponding plate, or whose reagent is dispensed in each of the plurality of wells. Here, a subject for determining the instruction content in detail can be the file generation unit 2124, and for this purpose, a table where the contents of the preparation work are the same, the instruction contents should be different can be prepared in advance in the file generation unit 2124.Alternatively, an individual who specifically determines the content of the instruction may be an operator of the automated analysis system 2000 according to a modality.

[0589] The file generated by the file generation unit 2124 can be written to a predetermined location by a file writing function to a predetermined location among API functions provided by API unit 2122.

[0590] Furthermore, file generation unit 2124 can register the file name in a predetermined location using the API function provided by API unit 2122. Here, the predetermined location where the file name is registered can be the file information storage unit 2522 of control module 2500, which will be described later.

[0591] Referring again to Figure 40, the 2200 analysis device will be described. The 2200 analysis device is used for qualitative analysis or Petition 870260047759, dated 05 / 19 / 2026, page 110 / 317 99 / 143 quantitative analysis of an analyte. In this respect, the 2200 analytical device can be referred to as a sample analytical device.

[0592] More specifically, the 2200 analysis device performs a nucleic acid amplification operation to amplify a nucleic acid that has a specific nucleotide sequence and a detection operation to detect the amplified nucleic acid, but without limitation to this.

[0593] In the meantime, the nucleic acid amplification operation described above and the nucleic acid detection operation described above are known in the art and, therefore, further description thereof will be omitted.

[0594] As shown in Figure 40, the analysis device 2200 includes an analysis device hardware (HW) unit 2210 and an analysis device management unit 2220.

[0595] The present disclosure relates to equipment or a structure in which the HW unit of the analysis device 2210 is physically implemented. Furthermore, the analysis device management unit 2220 can drive the HW unit of the analysis device 2210, output a driving result or various other messages as a log, and provide a predetermined application programming interface (API). The HW unit of the analysis device 2210 and the analysis device management unit 2220 itself will be described with reference to Figures 43 and 44.

[0596] Figure 43 is a block diagram that conceptually illustrates a configuration of the HW unit of analysis device 2210 of analysis device 2200. However, Figure 43 is merely illustrative.

[0597] With reference to Figure 43, a part of HW of analysis device 2210 of an analysis device 2200 includes a thermocycler 2211 and an optical module 2212. Petition 870260047759, dated 05 / 19 / 2026, page 111 / 317 100 / 143

[0598] The 2211 thermocycler is configured to perform a nucleic acid amplification operation. Specifically, the 2211 thermocycler is used for a nucleic acid amplification reaction based on polymerase chain reaction (PCR). More specifically, the 2211 thermocycler can perform a denaturation step, an annealing step, and an extension step to amplify DNA that has a specific nucleotide sequence.

[0599] Among these, the denaturation step is a step of separating double-stranded DNA into single-stranded DNA by heating a solution containing a sample containing double-stranded DNA as a template nucleic acid and a reagent to a specific temperature, for example, around 95 °C. The annealing step is a step of providing an oligonucleotide primer that has a nucleotide sequence complementary to a nucleotide sequence of a nucleic acid to be amplified, cooling the isolated single-stranded DNA to a specific temperature, for example, 60 °C, and linking the primer to a specific nucleotide sequence of the single-stranded DNA to form a partial DNA-primer complex. The extension step is a step of maintaining the solution at a specific temperature, for example, 72 °C, after the annealing step to form double-stranded DNA based on primers of partial DNA-primer complexes by DNA polymerase.

[0600] In one embodiment, the 2211 thermocycler can exponentially amplify DNA that has a specific nucleotide sequence by repeating the three steps described above, for example, 10 to 50 times.

[0601] In another embodiment, the thermocycler 2211 can simultaneously perform the annealing step and the extension step. In this case, the thermocycler 2211 can complete a cycle by performing two steps including a denaturation step and an annealing / extension step. Petition 870260047759, dated 05 / 19 / 2026, p. 112 / 317 101 / 143

[0602] The optical module 2212 is implemented to perform a nucleic acid detection operation. The optical module 2212 can analyze (or monitor) the amplification reaction performed by the thermocycler 2211 in real time. The optical module 2212 may include, for example, a plurality of light sources, an optical filter, a convex lens, a beam splitter, a photodetector, and the like.

[0603] Figure 44 below is a block diagram that conceptually illustrates the configuration of the 2220 analysis device management unit of the 2200 analysis device. However, Figure 44 is for illustrative purposes only.

[0604] With reference to Figure 44, the analysis device management unit 2220 of the analysis device 2200 includes a data output unit 2221, an API unit 2222, and a register output unit 2223. Here, the analysis device management unit 2220 and each of the configurations 2221 to 2223 included therein can be implemented by a processor and memory including instructions executable by the processor.

[0605] Here, the data output unit 2221 outputs a result detected or analyzed by the optical module 2212 illustrated in Figure 43 as data. The output data includes the light intensity for each of a plurality of cycles, but without limitation to this.

[0606] The API unit 2222 is configured to provide a predetermined API. In some cases, the analysis device 2200 can monitor or control an external object through the use of an API provided by the API unit 2222. Conversely, the external object can monitor or control the analysis device 2200 through the use of the API provided by the API unit 2222.

[0607] For example, the API provided by the API unit 2222 can be used to externally receive an execution command to trigger the analysis device 2200. Petition 870260047759, dated 05 / 19 / 2026, page 113 / 317 102 / 143

[0608] Furthermore, the API described above can be used to control the operation of a door (not shown) provided on the analysis device 2200. Specifically, the analysis device 2000 has a space in which the reaction vessel is housed. Furthermore, this space can be opened and closed by the door described above. Here, the API described above can support a door control function. Consequently, an external object, for example, the control module 2500, can open or close the door described above using an API provided by the API unit 2222.

[0609] In addition, the API described above can support a function to read a file located in a predetermined location, a filename, or content recorded in a file. Here, “content” includes text, an image, voice, or similar, which is recorded in a file, but is not limited to this. In one embodiment, API unit 2222 reads a filename stored in file information storage unit 2522 of control module 2500. Subsequently, a file with the read filename can be read from among the files stored in file storage unit 2521 of control module 2500. The object to be read can include multiple objects.For example, a file generated by the preparation device management unit 2120 of the preparation device 2100, that is, a file including referenced instrumentation when the analysis device 2200 performs a detection operation, can be included therein.

[0610] The 2223 log output unit is configured to output a status of the 2200 analysis device and several other statuses as a log. Examples of the output log may include status information indicating whether the 2200 analysis device is operating normally, abnormally, or interrupted, and an estimated time required until the 2200 analysis device... Petition 870260047759, dated 05 / 19 / 2026, page 114 / 317 103 / 143 complete a nucleic acid amplification operation and / or a nucleic acid detection operation currently in progress, but not limited to that.

[0611] Referring again to Figure 40, the transport device 2300 will be described. The transport device 2300 is configured to transport the reaction vessel between the preparation device 2100, the analysis device 2200, the automatic sealer 2400, and the vessel processing module 2800. Figure 45 illustrates one direction in which the reaction vessel is transported by the transport device 2300. Referring to Figure 45, the reaction vessel is transported from the preparation device 2100 to the transport device 2300, is transported from the transport device 2300 to the automatic sealer 2400, is again transported from the automatic sealer 2400 to the transport device 2300, and is then transported from the transport device 2300 to the analysis device 2200.Although not shown in Figure 45, the reaction vessel transported to the analysis device 2200 is transported to the container processing module 2800 and then discarded. Obviously, the transport path of the reaction vessel shown in Figure 45 is merely illustrative.

[0612] A specific configuration of the transport device 2300 is illustrated in Figure 46. With reference to Figure 46, the transport device 2300 includes a transport module 2310, a position detection unit 2320 and a contact detection unit 2330, but without limitation thereto.

[0613] Transport module 2310 is configured to transport the reaction vessel as it moves between preparation device 2100, analysis device 2200, automatic sealer 2400 and vessel processing module 2800.

[0614] The transport module 2310 can be implemented as a module. For example, when the preparation device 2100, the analysis device 2200 and the automatic sealer 2400 are arranged in the same horizontal plane, the module Petition 870260047759, dated 05 / 19 / 2026, page 115 / 317 Transport 104 / 143 2310 can be implemented as a module that is movable in the corresponding horizontal plane.

[0615] In contrast, the transport module 2310 can be implemented to include at least two configurations. For example, the transport module 2310 can include a lifting module 2311 that moves in the longitudinal direction and a crane module 2312 that moves in the transverse direction. This will be described in more detail below.

[0616] The preparation device 2100 may be arranged relatively in an upper portion of the automated analysis system 2000, while the analysis device 2200, the automatic sealer 2400, and the container processing module 2800 may be arranged relatively in a lower portion of the automated analysis system 2000. Furthermore, the analysis device 2200, the automatic sealer 2400, and the container processing module 2800 may be arranged in the same horizontal plane. In this case, the lifting module 2311 may move in a longitudinal direction, for example, towards the upper portion, to receive the reaction vessel from the preparation device 2100. Additionally, the lifting module 2311 may move in a longitudinal direction, for example, towards the lower portion, which simultaneously has the reaction vessel received from the preparation device 2100.

[0617] According to the present disclosure, when the lifting module 2311 completes its movement in the longitudinal direction, for example, towards the lower portion while having the reaction vessel received from the preparation device 2100, the crane module 2312 grasps and acquires the reaction vessel from the lifting module 2311 and then moves in the transverse direction. The automatic sealer 2400, the analysis device 2200, and the container processing module 2800 are arranged in the transverse direction of movement. Thus, the crane module 2312 can transport the reaction vessel to each of these modules 2200, 2400, 2800. Petition 870260047759, dated 05 / 19 / 2026, pp. 116 / 317 105 / 143 or recover from each of these modules 2200, 2400, 2800 while moving transversely with the reaction vessel.

[0618] However, this is only one example of how transport module 2310 is implemented or activated as described above, and the spirit of the present revelation is not limited to this. For example, transport module 2310 can be implemented in any form that has the capability to move with a reaction vessel.

[0619] The position detection unit 2320 is implemented as a position sensor. The position detection unit 2320 detects the position of the transport module 2310. As a result of the detection, the position detection unit 2320 can detect and provide, for example, how far the transport module 2310 is spaced from the preparation device 2100 or a relative position of the transport module 2310 with respect to the preparation device 2100.

[0620] The contact detection unit 2330 is implemented by a touch sensor. The contact detection unit 2330 detects whether the transport module 2310 and the reaction vessel come into contact with each other. As a result of the detection, the contact detection unit 2330 can detect and output, for example, whether the transport module 2310 is in contact with the reaction vessel or not in contact with the reaction vessel.

[0621] Referring again to Figure 40, the automatic sealer 2400 is described. The automatic sealer 2400 is implemented to seal the inlet, as the top surface, of the reaction vessel in which the sample for analysis is accommodated. Specifically, when the reaction vessel is delivered from the transport device 2300, the automatic sealer 2400 seals the top surface. Here, the sealed surface can be a side surface or a bottom surface instead of a top surface, but hereafter in this document it will be described on the premise that it is a top surface. Petition 870260047759, dated 05 / 19 / 2026, page 117 / 317 106 / 143

[0622] A specific configuration of the 2400 automatic sealer is illustrated in Figure 47. With reference to Figure 47, the 2400 automatic sealer includes, but is not limited to, a 2410 sealing unit, an API 2420 unit, and a 2430 register outlet unit.

[0623] As described above, the sealing unit 2410 can seal an inlet, for example, an upper surface, of the reaction vessel in which the sample for analysis is housed. For this purpose, the sealing unit 2410 can adhere the transparent film to the inlet of the reaction vessel. In this case, heat can be used for adhesion or an adhesive can be used.

[0624] The API unit 2420 is configured to provide a predetermined API. In some cases, the external object may monitor or control the state of the sealing unit 2410 through the use of the API provided by the API unit 2420.

[0625] The 2430 register output unit is configured to output a 2400 auto-sealer status as a register. Examples of the output register may include, but are not limited to, whether the sealing operation is currently in progress.

[0626] Referring again to Figure 40. Fan module 2600 is disposed in automated analysis system 2000 and operates to discharge air from automated analysis system 2000. At least one of the fan modules 2600 may be disposed in automated analysis system 2000.

[0627] Where the fan module 2600 is arranged in the internal structure of the automated analysis system 2000, and the operation control of the fan module 2600 will be described later.

[0628] The 2800 container processing module is configured to receive a reaction vessel, in which the detection of a target nucleic acid has been completed, from the 2200 analysis device. According to an example of Petition 870260047759, dated 05 / 19 / 2026, pp. 118 / 317 107 / 143 implementation, the transport device 2300 can retrieve the reaction vessel in which the detection operation is completed from the analysis device 2200 and transport the reaction vessel to the container processing module 2800, but without limitation to this.

[0629] The following is a description of the 2500 control module. With reference to Figure 40, the 2500 control module includes a 2510 control unit and a 2520 storage unit. However, it is not limited to this. Here, the 2500 control module and each of the 2510 to 2520 features included therein can be implemented by a processor and a memory that stores instructions executable by the processor.

[0630] Storage unit 2520 can store various types of information. For example, storage unit 2520 can store status information of transport device 2300, status information of preparation device 2100 or analysis device 2200, or status information of automatic sealer 2400.

[0631] The control unit 2510 controls a general operation of the automated analysis system 2000. For example, the control unit 2510 controls an operation of the transport device 2300. In addition, the control unit 2510 can control the automatic sealer 2400, the fan module 2600, or the container processing module 2800. Furthermore, the control unit 2510 can transfer a file between the preparation device 2100 and the analysis device 2200.

[0632] The operation of the transport device 2300 by the control unit 2510 will be described below. Under the control of the control unit 2510, the transport device 2300 moves towards the preparation device 2100. Then, the transport device 2300 receives the container of Petition 870260047759, dated 05 / 19 / 2026, page 119 / 317 108 / 143 sample analysis in which the sealing operation was not performed from preparation device 2100.

[0633] Furthermore, the transport device 2300 is moved from the preparation device 2100 to the automatic sealer 2400 under the control of the control unit 2510. Then, the reaction vessel is transported to the automatic sealer 2400 and the reaction vessel is sealed by the automatic sealer 2400.

[0634] Furthermore, the transport device 2300 is moved to the analysis device 2200 with the reaction vessel whose sealing operation is completed under the control of the control unit 2510. Then, the reaction vessel is transported to the analysis device 2200 and a detection operation is performed for the target nucleic acid.

[0635] Furthermore, the transport device 2300 is moved from the analysis device 2200 to the container processing module 2800 with the reaction vessel under the control of the control unit 2510. The reaction vessel is returned to the container processing module 2800.

[0636] Next, the control of the fan module 2600 by the control unit 2510 will be described. When the fan module 2600 is placed in the automated analysis system 2000 and how each feature is placed in the automated analysis system 2000 at that moment and how the transport device 2300 moves will be described with reference to Figure 48.

[0637] Figure 48 illustrates an appearance of the automated analysis system 2000 according to an embodiment and a device or module disposed therein. However, Figure 48 is only an example, and the spirit of the inventive concept is not limited to this.

[0638] With reference to Figure 48, a preparation device 2100 is arranged in an upper portion of the automated analysis system 2000. In addition, an enclosure 2700 is arranged under the automated analysis system 2000. It Petition 870260047759, dated 05 / 19 / 2026, page 120 / 317 109 / 143 It is clear that the arrangement of the housing 2700 is not limited to the lower portion of the preparation device 2100. For example, according to one embodiment, the housing 2700 may be arranged in an upper portion or in a lateral portion of the preparation device 2100. However, hereinafter in this document, the housing 2700 is considered to be arranged under the preparation device 2100.

[0639] The enclosure 2700 will be described in detail. An internal space 2710 is provided within the enclosure 2700. The analysis device 2200, the automatic sealer 2400, and the container processing module 2800 are arranged in the internal space 2710. In addition, the fan module 2600 can be arranged to pass through the enclosure 2700 for the purpose of discharging air from the internal space 2710 to the outside of the automated analysis system 2000.

[0640] The internal space 2710 may be sealed or isolated from the outside. For this purpose, the enclosure material 2700 may include a material through which air cannot pass. Furthermore, the enclosure 2700 may include a transparent or translucent material to allow the internal space 2710 to be seen from the outside.

[0641] The enclosure 2700 is provided with a defined passage 2730. The defined passage 2730 serves as a passage to connect the internal space 2710 of the enclosure 2700 to another space. With reference to Figure 48, the internal space 2710 of the enclosure 2700 can be connected to the preparation device 2100 or to the internal space of the preparation device 2100 through the defined passage 2730. That is, air can move between the internal space of the enclosure 2700 and the internal space of the preparation device 2100 through the defined passage 2730. Furthermore, the transport device 2300 described above can move between the preparation device 2100 and the internal space 2710 through the defined passage 2730.

[0642] The defined passage 2730 is opened and closed by the door part 2720. If the defined passage 2730 is closed by the door part 2720, the air does not Petition 870260047759, dated 05 / 19 / 2026, page 121 / 317 110 / 143 may move between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700. On the other hand, when the defined passage 2730 is opened by the door part 2720, air may move between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700.

[0643] Door part 2720 can open and close defined passage 2730 in several ways. For example, door part 2720 can be passively opened and closed by the movement of the transport device 2300. More specifically, while the transport device 2300 in the internal space 2710 moves to the preparation device 2100 through defined passage 2730, the transport device 2300 moves while pushing door part 2720 and, consequently, door part 2720 is open. Subsequently, when the transport device 2300 moves from the preparation device 2100 to the internal space 2710 of the enclosure 2700 through defined passage 2730, the transport device 2300 no longer pushes door part 2720 and, consequently, door part 2720 is closed.For this purpose, the door section 2720 can be operated in the direction of the arrow, as illustrated in Figure 48, and for this purpose, it can be connected to the enclosure 2700 by a hinge.

[0644] In contrast, the door section 2720 can be controlled by the control unit 2510 illustrated in Figure 40. For example, when the transport device 2300 in the internal space 2710 has to pass through the defined passage 2730, the door section 2720 is opened around the hinge by the control unit 2510. Subsequently, when the transport device 2300 moves from the preparation device 2100 to the internal space 2710 of the enclosure 2700 through the defined passage 2730, the door section 2720 is closed around the hinge by the control unit 2510.

[0645] Control unit 2510 interrupts the operation of fan module 2600 when the definitive path 2730 is open. For example, while Petition 870260047759, dated 05 / 19 / 2026, page 122 / 317 111 / 143 the transport device 2300 is passing through the defined passage 2730 or while the transport device 2300 is inside the preparation device 2100, the defined passage 2730 is open and during this period, the control unit 2510 interrupts the fan operation module 2600.

[0646] More specifically, the transport device 2300 is normally stationary in the internal space 2710 of the enclosure 2700. In this case, the defined passage 2730 is closed by the door part 2720. In this case, the fan module 2600 may be stopped or in operation, and whether it should operate or stop is determined by the control unit 2510.

[0647] Furthermore, the transport device 2300 can move from the internal space 2710 towards the interior of the preparation device 2100 and can pass through the defined passage 2730 in the process. The control unit 2510 interrupts the operation of the fan module 2600 while the transport device 2300 passes through the defined passage 2730, that is, during the passage.

[0648] Furthermore, the transport device 2300 that has passed through the defined passage 2730 approaches the preparation device 2100 to receive the reaction vessel from it and then passes through the defined passage 2730 to return to the internal space 2710. During this period, the defined passage 2730 is open and the control unit 2510 interrupts the operation of the fan module 2600 during this period.

[0649] That is, according to one embodiment, the operation of the fan module 2600 is interrupted while the definite passage 2730 is open. Therefore, since the fan module 2600 does not operate despite the opening of the definite passage 2730, the possibility of air exchange between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200 is reduced. Petition 870260047759, dated 05 / 19 / 2026, page 123 / 317 112 / 143

[0650] In general, air should not be exchanged between the internal space of the preparation device 2100 and the internal space 2710 in which the analysis device 2200 is placed. This is because when air is exchanged, pathogens that may be included in the air can move from one space to another, and thus contamination or infection can occur.

[0651] However, in one embodiment, a situation may occur in which the defined passage 2730 is open and, in that case, when the fan module 2600 is operated, there is a high probability that air will be exchanged between the internal space of the preparation device 2100 and the internal space 2710 in which the analysis device 2200 is located. Consequently, in one embodiment, the control unit 2510 may interrupt the operation of the fan module 2600 in the situation described above, thereby reducing the possibility of the contamination or infection described above.

[0652] In the meantime, the situation in which control unit 2510 interrupts the operation of fan module 2600 may include not only the case in which the defined passage 2730 is open, but also the case in which it is closed. This will be described in more detail below.

[0653] When the transport device 2300 is moving with the unsealed reaction vessel, the control unit 2510 interrupts the operation of the fan module 2600 even when the defined passage 2730 is closed. For example, while the transport device 2300 is in the internal space 2720 after receiving the unsealed reaction vessel from the preparation device 2100 and passing through the defined passage 2730, the control unit 2510 can interrupt the operation of the fan module 2600. That is, the control unit 2510 can interrupt the operation of the fan module 2600 until the transport device 2300 passes through the defined passage 2730 with the unsealed reaction vessel, reaches the automatic sealer 2400, and the sealing operation is completed. Petition 870260047759, dated 05 / 19 / 2026, page 124 / 317 113 / 143 Subsequently, once the sealing operation is complete, control unit 2510 can resume operation of fan module 2600 from that point onward.

[0654] On the other hand, the control unit 2510 can interrupt the operation of the fan module 2600 until the transport device 2300 passes through the defined passage 2730 with the reaction vessel unsealed and then completes the transport to the analysis device 2200 through the automatic seal 2400. Subsequently, when the transport of the reaction vessel to the analysis device 2200 is completed, the control unit 2510 can resume the operation of the fan module 2600 from that moment.

[0655] That is, according to one embodiment, the operation of the fan module 2600 can be interrupted while the unsealed reaction vessel is located in the internal space 2710 or for a longer period. Consequently, a phenomenon in which various materials, for example, pathogens, contained in an unsealed reaction vessel are spread into the air of the internal space 2710 can be reduced.

[0656] In general, pathogens or similar substances may be included in an unsealed reaction vessel and these may be discharged into the air, particularly into the internal space 2710. In this situation, when the fan module 2600 is operated, air is discharged from the internal space 2710 to the outside of the automated analysis system 2000, and there is a risk that pathogens or similar substances may be mixed with the air and discharged to the outside depending on the circumstances.

[0657] Consequently, in one embodiment, when the reaction vessel that is not sealed is located in the internal space 2710, the fan module 2600 is not operated at that time and, therefore, the pathogen described above or similar pathogens cannot be discharged from inside the automated analysis system 2000. Petition 870260047759, dated 05 / 19 / 2026, page 125 / 317 114 / 143

[0658] Hereafter in this document, with reference to Figures 49 to 56 together with Figure 48, the control of the fan module described above will be described as an example.

[0659] In Figures 49 to 56, the position of the transport device 2300 is indicated respectively by (1) to (8).

[0660] With reference to Figure 49, the transport device 2300 is in position (1). This position is referred to as an initial position. When the automated analysis system 2000 is not activated and is in an inactive state, or when the automated analysis system 2000 completes an analysis of the reaction vessel once and waits for the next time, the transport device 2300 is located in this position.

[0661] In this case, the defined passage 2730 is closed by the door part 2720. Furthermore, the fan module 2600 can be switched on or off according to the temperature of the internal space 2710, as illustrated in Figure 49. The following will be described based on the premise that the fan module 2600 is switched on.

[0662] Figure 50 illustrates a moment when the transport device 2300 begins to move towards the preparation device 2100 from the initial position of (1). (2) in Figure 50 shows an example of a position where the transport device 2300 has moved from (1). This position (2) occurs before the transport device 2300 has yet passed through the defined passage 2730. In this case, the defined passage 2730 is still closed by the door part 2720. Furthermore, as illustrated in Figure 50, the fan module 2600 is ON->OFF.

[0663] Figure 51 shows the moment when the transport device 2300 is located in the preparation device 2100 (internal space of) through the defined passage 2730. (3) in Figure 51 shows an example of a point where the Petition 870260047759, dated 05 / 19 / 2026, page 126 / 317 115 / 143 transport device 2300 is located in the preparation device 2100. With reference to Figure 51, the defined passage 2730 is in the open state by the door part 2720. In this case, there is a possibility that air will move between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200. In this case, the operation of the fan module 2600 is interrupted by the control unit 2510. Therefore, the possibility of air movement between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200 can be reduced compared to when the fan module 2600 is operated, and even if air moves, the amount of air may be reduced compared to when the fan module 2600 is operated.

[0664] In Figure 51, the transport device 2300 can receive an unsealed reaction vessel from the preparation device 2100.

[0665] Figure 52 shows the moment when the transport device 2300 passes through the defined passage 2730 in the internal space of the preparation device 2100 and returns to the internal space 2710 of the enclosure 2700 of the analysis device 2200. (4) Figure 52 illustrates an example of a location where the transport device 2300 is located in the internal space 2710

[0666] With reference to Figure 52, the defined passage 2730 is in a closed state by the port part 2720. In this case, there is no possibility of air moving between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200.

[0667] However, the transport device 2300 may have an unsealed reaction vessel received from the preparation device 2100 and may be in the internal space 2710. In this case, the operation of the fan module 2600 is interrupted by the control unit 2510. Petition 870260047759, dated 05 / 19 / 2026, page 127 / 317 116 / 143

[0668] Therefore, the possibility of pathogens that may be contained in the reaction vessel leaking into the internal space 2710 can be reduced compared to the case in which the ventilator module 2600 operates.

[0669] Figure 53 shows a moment when the transport device 2300 has moved completely to the automatic seal 2400. (5) in Figure 53 illustrates the position of the transport device 2300 at that moment. With reference to Figure 53, the defined passage 2730 is in a closed state by the door part 2720. In this case, there is no possibility of air moving between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200. Additionally, the fan module 2600 is also interrupted.

[0670] In Figure 53, the automatic sealer 2400 receives a reaction vessel that is not sealed from the transport device 2300 and performs a sealing operation for the reaction vessel.

[0671] Figure 54 shows a moment when the transport device 2300 completes the transport of the automatic sealer 2400 to the analysis device 2200. (6) in Figure 54 illustrates the position of the transport device 2300 at that moment.

[0672] With reference to Figure 54, the defined passage 2730 is in a closed state by the port part 2720. In this case, there is no possibility of air moving between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200.

[0673] In Figure 54, the analysis device 2200 receives a reaction vessel in which a sealing operation is completed from the transport device 2300 and detects a target nucleic acid from the reaction vessel. In this process, heat is generated in the analysis device 2200. Petition 870260047759, dated 05 / 19 / 2026, page 128 / 317 117 / 143

[0674] Consequently, as illustrated in Figure 54, when the reaction vessel is delivered to the analysis device 2200, the control unit 2510 restarts the operation of the fan module 2600 from that moment. Then, the heat generated by the operation of the analysis device 2200 is discharged from the internal space 2710 of the automated analysis system 2000.

[0675] Figure 55 illustrates a moment when the transport device 2300 completes the transport of the analysis device 2200 to the container processing module 2800. (7) in Figure 55 illustrates the position of the transport device 2300 at that moment.

[0676] With reference to Figure 55, the defined passage 2730 is in a closed state by the port part 2720. In this case, there is no possibility of air moving between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200.

[0677] In Figure 55, the transport device 2300 transports the reaction vessel received from the analysis device 2200 to the vessel processing module 2800. Then, the reaction vessel is retrieved.

[0678] Figure 56 illustrates a state in which the transport device 2300 completes the movement of the container processing module 2800 to the initial position. (8) in Figure 56 illustrates the position of the transport device 2300 at that moment.

[0679] With reference to Figure 56, the defined passage 2730 is in a closed state by the port part 2720. In this case, there is no possibility of air moving between the internal space of the preparation device 2100 and the internal space 2710 of the enclosure 2700 of the analysis device 2200. Furthermore, the fan module 2600 is in an ON state.

[0680] In the meantime, control unit 2510 can control a fan rotation speed in fan module 2600. For example, the Petition 870260047759, dated 05 / 19 / 2026, page 129 / 317 The 118 / 143 control unit 2510 can control the fan rotation speed in the fan module 2600 to be fast or slow according to the internal temperature of the automated analysis system 2000. For this purpose, although not illustrated in the automated analysis system 2000, a temperature measurement unit for measuring the internal space temperature 2710 can be included.

[0681] In the meantime, at least one of the fan modules 2600 described above may be provided in the automated analysis system 2000. Some of the fan modules 2600 may be activated independently if the internal space temperature 2710 is below or exceeds the reference value while the analysis device 2200 is being activated and the set passage 2730 is closed, and the remaining fan modules 2600 may be activated only when the internal space temperature 2710 exceeds the reference value while the analysis device 2200 is being activated and the set passage 2730 is closed. The control of the fan module 2600 may be performed by the control unit 2510.

[0682] Figure 57 is a flowchart of a fan module control method that can be performed by the automated analysis system 2000 according to one embodiment. However, since Figure 57 is only an example, the spirit of the present disclosure is not limited to that illustrated in Figure 57.

[0683] With reference to Figure 57, in the fan module control method, a step of opening the defined passage 2730 of the enclosure 2700 of the analysis device 2200 by the port part 2720 (S100) is performed.

[0684] So, while the defined passage 2730 is open by the door part 2720 in S100, the control unit 2510 interrupts the operation of the fan module 2600 (S200).

[0685] Hereafter in this document, the method of controlling the fan module is performed by the automated analysis system 2000, and the description Petition 870260047759, dated 05 / 19 / 2026, page 130 / 317 A detailed description of the corresponding method, as per section 119 / 143, will be referred to in the description of the automated analysis system 2000.

[0686] In the meantime, the method illustrated in Figure 57 can be implemented on a computer-readable record medium storing a computer program programmed to perform the steps included in each of these methods, or it can be implemented in the form of a computer program stored on a computer-readable record medium as a computer program programmed to perform each step included in these methods.

[0687] As described above, according to one embodiment, the risk of pathogens that may be included in the reaction vessel leaking out and dispersing into the air through the operation of the fan module can be reduced.

[0688] Furthermore, the possibility of mixing air inside a preparation device to perform the preparation to detect the target nucleic acid and the air around an analysis device to perform the detection of the target nucleic acid can be reduced. ASSEMBLY METHOD

[0689] Next, a method for assembling the automated analysis system will be described.

[0690] The present disclosure relates to a self-contained analytical device used for sample preparation and analysis for molecular diagnostics, a self-contained preparation device and a method for assembling the three types of devices that assemble a transport unit to carry a reaction vessel between the two devices to perform a series of processes from sample preparation to analysis in a single block.

[0691] The present inventors have made great efforts to develop a method to ensure user convenience and safety, while at the same time maintaining the independence of each device from the devices Petition 870260047759, dated 05 / 19 / 2026, page 131 / 317 120 / 143 existing autonomous devices licensed for molecular diagnostics. As a result, the present inventors have developed a method for assembling molecular diagnostic devices that uses a transport unit to form a movement pathway for a reaction vessel between the autonomous analysis device and the autonomous preparation device, without impairing the independence of the autonomous analysis device and the autonomous preparation device.

[0692] The present disclosure provides a method for fabricating an assembly of a molecular diagnostic device.

[0693] According to one aspect of the disclosure, a method is provided for manufacturing an assembly of a molecular diagnostic device, wherein the assembly includes a self-contained analysis device, a transport device, and a self-contained preparation device, wherein the transport device carries a reaction vessel; wherein the self-contained preparation device provides a reaction vessel containing a sample analyzable by the self-contained analysis device; wherein the self-contained analysis device analyzes the sample contained in the reaction vessel; and wherein the method includes the following steps: (a) providing the self-contained analysis device and the self-contained preparation device to the transport device; and (b) aligning the self-contained analysis device, the transport device, and the self-contained preparation device, wherein the alignment forms a path of movement for the reaction vessel between the self-contained preparation device and the self-contained analysis device.

[0694] Molecular diagnostics refers to the acquisition of desired information through the application of molecular biology technology to analyze genetic information contained in a sample or biological markers contained in a protein in a medical test. A biological marker refers to an analyte target and may be, for example, a target nucleic acid sequence or a Petition 870260047759, dated 05 / 19 / 2026, p. 132 / 317 121 / 143 amino acid sequence. The desired information may be information about the presence, absence, or quantity of the biological marker.

[0695] A molecular diagnostic device refers to a device that can be used in such molecular diagnostics. A molecular diagnostic device may include an analysis device for identifying genetic information (e.g., a nucleic acid amplification device, a sequencing device, and a DNA chip system) and an analysis device for identifying amino acid sequence information (e.g., an antibody-based analysis device). In addition, a molecular diagnostic device may include a preparation device (e.g., an extraction device or a PCR setup device) for preparing a sample in a state in which an analysis device for identifying genetic information or amino acid information can perform an identification process. The target analyte is referred to as the analyte or target analyte.

[0696] According to one embodiment of the present disclosure, the molecular diagnostic device may be a stand-alone device. A stand-alone device refers to a device configured to independently perform its own functions without involving devices with other functions.

[0697] The analytical device of the present disclosure is a stand-alone analytical device and the preparation device of the present disclosure is a stand-alone preparation device. Therefore, according to an embodiment of the present disclosure, the stand-alone analytical device and / or the stand-alone preparation device of the present disclosure may be a molecular diagnostic device.

[0698] According to an embodiment of the present disclosure, the stand-alone analysis device may be a previously licensed analysis device and the stand-alone preparation device may be a preparation device. Petition 870260047759, dated 05 / 19 / 2026, p. 133 / 317 122 / 143 previously licensed. The license may be a license to use a corresponding device for molecular diagnostics. Specifically, the license may be a license to use a corresponding device in the use of an In Vitro Diagnostic (IVD). The term in vitro diagnostic medical device means a device including a reagent used as a medical device used in vitro for the purpose of providing information, such as diagnosis, prognosis, observation, determination of adequacy of blood or tissue, etc., of a disease through testing substances in a sample derived from a human body as a sample.

[0699] Therefore, the preparation device or the analysis device previously licensed in this disclosure includes the preparation device or the analysis device itself that is licensed as an in vitro diagnostic medical device, and the preparation device or the analysis device is included in the previously licensed preparation device or analysis device, even when the kit for determining a specific disease or infection is licensed as an in vitro diagnostic medical device to use the preparation device or the analysis device.

[0700] The license may be a license approved by the health authorities of each country. Specifically, the country may be Korea, the United States, or Europe.

[0701] In the present disclosure, an assembly refers to a structure in which two or more devices are combined. At least one of the two or more devices comprising the assembly may be a stand-alone device. According to an embodiment of the present disclosure, at least one of the devices constituting the assembly may be a device pre-licensed as an in vitro diagnostic medical device, and the pre-licensed device may be used independently as an in vitro diagnostic medical device without a separate license, even if the device is included in the assembly of the present disclosure. Petition 870260047759, dated 05 / 19 / 2026, p. 134 / 317 123 / 143

[0702] In other words, in the conventional complete automolecular diagnostic system, several modules included therein are manufactured for the complete automolecular diagnostic system, and the complete molecular diagnostic system itself is a device that performs several functions, whereas the assembly of the present disclosure is not a device in itself, but an assembly of a plurality of devices in which a plurality of devices that have the capability to perform their own functions are elaborately connected.

[0703] According to an embodiment of the present disclosure, the assembly may be the automated analysis system 1000 described above.

[0704] The assembly of the present disclosure includes a preparation device. The preparation device prepares an analytical sample including, or presumed to include, an analyte. In this descriptive report, the terms preparation device and sample preparation device have the same meaning and may be used interchangeably.

[0705] A preparation device is a device that prepares or preprocesses a sample into a state in which an analytical device can proceed with an identification process. For example, the preparation device may be, for instance, an extraction device to separate a nucleic acid or a polypeptide from a sample or a setup device to mix the separated nucleic acid or polypeptide with a reagent required for analysis so that the analytical device can perform a desired analysis.

[0706] The present disclosure assembly also includes an analysis device. The analysis device analyzes a sample contained in the reaction vessel. Specifically, the analysis device analyzes a sample and provides information about the presence or quantity of an analyte in the sample. The analysis device may include an analysis device for identifying genetic information (by Petition 870260047759, dated 05 / 19 / 2026, page 135 / 317 124 / 143 example, a nucleic acid amplification device, a sequencing device, a DNA chip system) and an analysis device for identifying amino acid sequence information (e.g., an antibody-based analysis device).

[0707] As used in this document, the terms analytical device and sample analytical device may be used interchangeably with each other and refer to a device used for qualitative or quantitative analysis of an analyte.

[0708] Sample analysis includes detecting the presence of an analyte and measuring its content.

[0709] According to one embodiment, the sample analysis device is a real-time detection device. According to one embodiment, the sample analysis device is a real-time nucleic acid detection device. According to one embodiment, the sample analysis device is a real-time PCR device.

[0710] The assembly of the present disclosure also includes a transport unit. The transport unit carries the reaction vessel. The transport unit includes a transport device and an enclosure. The transport device includes a lifting module and a crane module.

[0711] According to one embodiment of the present disclosure, the transport unit may include at least one enclosure, and the enclosure may include a second defined passage through which the reaction vessel passes.

[0712] The enclosure can accommodate the stand-alone analysis device or the stand-alone preparation device.

[0713] According to an embodiment of the present disclosure, the enclosure may include positioning means for alignment. In this descriptive report, the terms positioning means and means for determining alignment Petition 870260047759, dated 05 / 19 / 2026, page 136 / 317 125 / 143 position have the same meaning and can be used together. Positioning means allow the analysis device or preparation device housed in the housing to be located at a predetermined point. The positioning means can be, for example, a connecting means that fixes a lower portion of the analysis device or preparation device, or a concave groove, an overhanging structure, or a gripping portion on an inner surface of the housing in contact with the analysis device or preparation device. The analysis device or preparation device, by means of the positioning means, is positioned at a predetermined location inside the housing and can form a path of movement to the reaction vessel.

[0714] The casing includes a second defined passage through which the reaction vessel passes. The reaction vessel enters and exits through the second defined passage. Therefore, the movement pathway formed by the reaction vessel can be formed to pass through the second defined passage.

[0715] According to one embodiment of the present disclosure, the second defined passage may include a gate device. The gate device may be opened when the reaction vessel is moved through the second defined passage and may be operated to be closed after the movement is completed.

[0716] The position of the second defined passage is not particularly limited and may, for example, be positioned on an upper portion, a lower portion, or a side surface of the enclosure. According to one embodiment of the present disclosure, the second defined passage may be located above the enclosure.

[0717] According to an embodiment of the present disclosure, the transport unit of the present disclosure may include environmental control means. The environmental control means is an environmental control means for controlling the internal environment of the transport unit's enclosure. Petition 870260047759, dated 05 / 19 / 2026, page 137 / 317 126 / 143

[0718] The environment adjustment means serves to adjust the internal environment of the transport unit's housing to the same environment as when a standalone device (e.g., a standalone analysis device or a standalone preparation device) positioned inside the housing is not included in the assembly of the present disclosure and is used alone. Consequently, the same performance as when the standalone device located in the housing is used alone can be exhibited. Conventional complete automolecular diagnostic system modules are not used alone and were originally designed to operate in an environment provided by the corresponding system. Therefore, the conventional complete automatic automolecular diagnostic system does not need to have an environment control means to be equal to the environment in which each module is used alone.

[0719] The means of environmental control of the present disclosure may include a cooling and heating device, such as a fan, an air conditioner, a heating wire, a lamp and the like, and a control unit to control the same.

[0720] Furthermore, the environmental control means of the transport unit according to the present disclosure can be controlled in conjunction with the operation of another part of the transport unit. According to one embodiment of the present disclosure, the environmental control means of the present disclosure can be an environmental control means linked to the operation. The environmental control means linked to the movement can operate in conjunction with the operation of other components of the transport unit.

[0721] Both the autonomous analysis device and the autonomous preparation device may be located within the housing of the transport unit of the present disclosure. However, in general, the autonomous preparation device has a shielding means to separate the interior and exterior by itself. This occurs Petition 870260047759, dated 05 / 19 / 2026, page 138 / 317 127 / 143 because, even when the preparation device is used alone, a means is needed to separate the interior and exterior of the preparation device in order to prevent contamination of samples, reaction vessels, and various reagents housed within the preparation device. However, the present disclosure does not include a means for shielding the self-contained analytical device. Therefore, according to one embodiment of the present disclosure, the self-contained analytical device may be located within the housing of the transport unit.

[0722] The transport unit of the present disclosure carries the reaction vessel. Therefore, according to one embodiment of the present disclosure, the transport unit may include one or more transport modules.

[0723] According to one embodiment of the present disclosure, the transport unit may include a lifting module and a crane module.

[0724] According to one embodiment of the present disclosure, the lifting module can be configured to transport the reaction vessel through the second defined passage of the transport unit, and the crane module can be configured to transport the reaction vessel within the housing of the transport unit. As a result, the size of the second defined passage of the housing can be minimized so that the movement path of the reaction vessel can be established between the two devices, while at the same time maintaining the mutual isolation effects of the preparation device and the analysis device. To implement both the three-dimensional movement of the transport unit within the housing and the transport of the reaction vessel through the second defined passage with a transport module, an expensive multi-joint device is required.

[0725] According to one embodiment of the present disclosure, the autonomous analysis device may be located in the housing of the transport unit, in which case the lifting module transports the reaction vessel from the interior of the Petition 870260047759, dated 05 / 19 / 2026, page 139 / 317 128 / 143 autonomous preparation device for the interior of the transport unit enclosure and the crane module transports the reaction vessel inside the transport unit enclosure.

[0726] According to one embodiment of the present disclosure, the transport unit of the present disclosure may include two transport modules, and the autonomous preparation device and the autonomous analysis device are aligned respectively to different transport modules. The combination of the present disclosure can construct a one-step molecular diagnostic process through the use of a conventional preparation device or analysis device independently used in the combination. Thus, the molecular diagnostic device of the present disclosure eliminates the need to discard existing molecular diagnostic devices and construct an expensive automated molecular diagnostic system. The transport unit must have the capability to form a reaction vessel movement pathway between the designed and manufactured preparation device and analysis device without considering the transport of the reaction vessels between themselves.For this purpose, the transport unit of the present disclosure includes a lifting module and a crane module, and the autonomous preparation device and the autonomous analysis device are aligned respectively to different transport modules. Consequently, in the configuration of the assembly of the present disclosure, the autonomous preparation device and the autonomous analysis device can be selected independently of each other. In other words, according to the assembly and manufacturing method of the present disclosure, the selection of the autonomous preparation device is not limited by the use of a specific autonomous analysis device, and the selection of the autonomous analysis device is not limited by the use of a specific autonomous preparation device. Petition 870260047759, dated 05 / 19 / 2026, page 140 / 317 129 / 143

[0727] The manufacturing method for assembling the molecular diagnostic device of the present disclosure includes the following steps.

[0728] The method may additionally include: (a) providing the self-contained analysis device and the self-contained preparation device for the transport unit; and (b) aligning the self-contained analysis device, the transport unit and the self-contained secretion device, wherein the alignment forms a movement pathway for the reaction vessel between the self-contained preparation device and the self-contained analysis device.

[0729] In step (a), the autonomous analysis device and the autonomous preparation device are provided for the transport unit.

[0730] As described above, the transport unit may include at least one enclosure, and the enclosure may include a second defined passage through which the reaction vessel passes. According to one embodiment of the present disclosure, the provision of the self-contained analysis device for the transport unit may include placing the self-contained analysis device in the enclosure of the transport unit.

[0731] In addition, the enclosure includes positioning means for alignment, and step (a) of providing the autonomous analysis device and the transport unit may include a step of positioning the autonomous analysis device on the positioning means.

[0732] Figure 34 is a view describing the provision of the autonomous analysis device 1200 for the housing 1300 of the transport unit 1050 according to an embodiment of the present disclosure. As shown in Figure 6, in the provision of the present disclosure, the autonomous analysis device 1200 is positioned in the housing 1300 of the transport unit 1050. The housing 1300 may dispose of the second positioning means 1390 in a predetermined position for the autonomous analysis device 1200. The second positioning means 1390 may be, for example, a linking unit that secures a lower portion of the Petition 870260047759, dated 05 / 19 / 2026, page 141 / 317 130 / 143 analysis device or preparation device or a concave groove, a protruding structure or a gripping unit formed on an inner surface of the housing in contact with the analysis device or preparation device.

[0733] ​​In step (a), the autonomous preparation device is also provided for the transport unit.

[0734] The supply of the autonomous preparation device refers to the positioning of the autonomous preparation device in relation to the transport unit for the purpose of completing the movement path to the analysis device and the reaction vessel.

[0735] According to one embodiment of the present disclosure, the self-contained preparation device may include a first defined passage through which the reaction vessel may pass, and the provision may include the positioning of the second defined passage of the transport unit and the first defined passage to face each other.

[0736] In the self-contained preparation device of the present disclosure, the opening (the first defined passage) of the self-contained preparation device and the opening (the second defined passage) of the enclosure can be positioned so that they face each other. The inlet and outlet of the reaction vessel in the self-contained preparation device are performed through the first defined passage, and the inlet and outlet of the reaction vessel in the enclosure are performed through the second defined passage.

[0737] Therefore, when the self-contained preparation device is positioned so that the first defined passage is adjacent to and faces the second defined passage, the exposure of the reaction vessel to the outside while the reaction vessel is moving can be blocked or minimized. Petition 870260047759, dated 05 / 19 / 2026, page 142 / 317 131 / 143

[0738] With reference to Figure 6, a second defined passage 1310 is formed on an upper surface of the housing 1300 of the transport unit 1050. Furthermore, a third positioning means 1395 is provided for positioning the autonomous preparation device 1100 provided for the transport unit 1050. Figure 17 illustrates the transport unit 1050 in a state in which the lifting module 1410 is exposed. Figures 36A to 36C are diagrams to describe the provision of the preparation device 1100 for the transport unit 1050.

[0739] The first defined passage 1130 and the second defined passage 1310 of the enclosure 1300 are positioned facing each other so that the lifting module 1410 can move into the preparation device 1100 through the first defined passage 1130 of the preparation device 1100 (see Figures 36C and 6).

[0740] In order to facilitate such provision, a third positioning means 1395 for positioning the self-contained preparation device 1100 provided for the transport unit 1050 is provided on the upper surface of the housing 1300 (see Figure 6).

[0741] Consequently, a movement pathway of the reaction vessel from the preparation device 1100 to the analysis device 1200 can be formed. According to one embodiment of the present disclosure, the movement pathway of the reaction vessel can be formed through the second defined passage and the first defined passage.

[0742] In step (b), the autonomous analysis device, the transport unit and the autonomous preparation device are aligned.

[0743] Through the alignment step, a movement path of the reaction vessel is formed between the autonomous preparation device and the autonomous analysis device. Petition 870260047759, dated 05 / 19 / 2026, page 143 / 317 132 / 143

[0744] The alignment may specifically include a first alignment stage of forming a reaction vessel movement pathway between the autonomous preparation device and the transport unit, and a second alignment stage of forming a reaction vessel movement pathway between the autonomous analysis device and the transport unit.

[0745] The production method of the present disclosure is a method for configuring an assembly that has the capability to implement a one-step molecular diagnostic process through the use of autonomous preparation devices and autonomous analysis devices that were produced independently without considering the formation of a displacement path for reaction vessels. Therefore, the autonomous preparation device and the autonomous analysis device used in the present disclosure do not always have a structure that has the capability to form a movement path for a reaction vessel through direct alignment with each other. Therefore, the present disclosure forms the movement path of the reaction vessel between the autonomous preparation device and the autonomous analysis device using the transport unit.Specifically, according to the method of the present disclosure, the method may include: a first alignment step to form a reaction vessel movement pathway between the stand-alone preparation device and the transport unit; and a second alignment step to form a reaction vessel movement pathway between the stand-alone analysis device and the transport unit. Consequently, the manufacturing method of the present disclosure may assemble an assembly that has the capability to implement a one-step molecular diagnostic process through the use of an independently manufactured stand-alone preparation device and a stand-alone analysis device without considering the formation of a reaction vessel movement pathway. Petition 870260047759, dated 05 / 19 / 2026, page 144 / 317 133 / 143

[0746] Additionally, the transport unit of the present disclosure may include at least two transport modules, and the autonomous preparation device and the autonomous analysis device may be aligned respectively to different transport modules. Thus, a reaction vessel movement pathway can be formed significantly easier compared to the case in which a transport module aligns each preparation device and analysis device.

[0747] Specifically, the transport unit may include a lifting module and a crane module. According to an embodiment of the present disclosure, the alignment may include: (c1) aligning the lifting module and the autonomous preparation device; and (c2) aligning the crane module and the autonomous analysis device.

[0748] As described above, the transport unit of the present disclosure may include a lifting module and a crane module, the lifting module may be configured to transport the reaction vessel through the defined second passage of the transport unit and the crane module may be configured to transport the reaction vessel within the enclosure of the transport unit. The embodiment refers to a case in which the autonomous analysis device is positioned within the enclosure of the transport unit and the autonomous preparation device is positioned outside the enclosure.

[0749] The lifting module that transports the reaction vessel through the second defined passage of the transport unit is aligned with the autonomous preparation device to transport the reaction vessel prepared in the autonomous preparation device to the enclosure via the lifting module. Inside the enclosure, the lifting module transports the reaction vessel to the crane module. A crane module that transports the reaction vessel inside the transport unit enclosure is aligned with an analysis device positioned inside the enclosure and positions the transported reaction vessel in a position Petition 870260047759, dated 05 / 19 / 2026, page 145 / 317 134 / 143 predetermined of the analysis device. Thus, a movement path of the reaction vessel is formed between the autonomous preparation device and the autonomous analysis device.

[0750] With reference to Figures 36A to 36C, the lifting module 1410 and the preparation device 1100 are aligned so that the lifting module 1410 can pass through the first defined passage 1130 of the preparation device 1100. In detail, the lifting module 1410 can be aligned to adjust an overhanging height (see Figure 36B) so that the preparation device 1100 can deliver the reaction vessel to the lifting module, and the preparation device 1100 can be aligned to adjust a position of the preparation device so that the lifting module 1410 can pass through the first defined passage 1130, and aligned to adjust a position of the preparation device 1100 so that a third transport module (not shown) of the preparation device can deliver the reaction vessel to the analytical sample vessel shelf 1416 of the lifting module 1410.

[0751] According to one embodiment of the present disclosure, the method may include learning, by the transport unit, a position of the autonomous analysis device.

[0752] According to one embodiment of the present disclosure, the method may include learning, by the autonomous preparation device, a position of the transport unit.

[0753] When the autonomous preparation device and the autonomous analysis device are positioned in the transport unit through the alignment step, their relative positions are mechanically adjusted to form the movement path of the reaction vessel. Petition 870260047759, dated 05 / 19 / 2026, page 146 / 317 135 / 143

[0754] The method for manufacturing the reaction vessel of the present disclosure includes a step of precisely transporting the reaction vessel between devices through fine control of the movement of a lifting module, a crane module, or a pipette module of a preparation device, which are transport modules of a transport unit, in a software manner separate from the alignment step. This step is referred to as the teaching step and is performed in the last step after the completion of the mechanical positioning of each device. The teaching can be performed in such a way that a mobile module of one device learns a specific location of another device.

[0755] The manufacturing method of the present disclosure may include a step in which the transport unit learns the position of the autonomous analysis device. This can be accomplished in such a way that the transport module of the transport unit touches a reaction vessel previously housed in the autonomous analysis device to store its position.

[0756] The manufacturing method of the present disclosure may additionally include learning, by the preparation device, the position of the transport unit. This can be accomplished in such a way that the pipette module of the preparation device touches a reaction vessel previously housed in the transport module to memorize the position.

[0757] As described above, the manufacturing method of the present disclosure can transport the reaction vessel to the reaction vessel that accommodates part of the analysis device of the transport module in the case of the analysis device without a module to transport the reaction vessel, and can transport the reaction vessel to the transport module by learning the position of the transport module in the case of the preparation device to which the pipette module can transport the reaction vessel. In order for the transport module to be able to collect the reaction vessel in the preparation device, it must be designed so that the module of Petition 870260047759, dated 05 / 19 / 2026, page 147 / 317 136 / 143 transport can enter the workspace within the preparation device. In this case, the mechanical structure of the transport module may limit the movement of the pipette module of the preparation device, and to solve this problem it may be necessary to change the structure of a main part of the preparation device. However, when the pipette module of the preparation device transports the reaction vessel to the place where the transport module is located, the space occupied by the mechanical structure of the transport module in the preparation device can be minimized, and the pipette module can perform the sample preparation process without being disturbed by the transport module, without structural changes to the main parts of the preparation device.

[0758] With reference to Figures 21 and 22, it is described that the transport unit 1050 learns a position from the autonomous analysis device 1200. Specifically, the position of the analysis device 1200 can be realized by the crane module 1430 of the transport unit 1050. As shown in Figure 22, the reaction vessel 1500 can be placed in the sample holder of the analysis device 1200, and the gripper 1437 of the crane module 1430 can be placed in contact with the sample holder 1500 to learn the position of the analysis device 1200. Consequently, the transport unit 1050 stores the position of the analysis device 1200 to more precisely adjust the movement of the crane module 1430.

[0759] According to one embodiment of the present disclosure, the learning of the crane module 1430 can be performed not only for the analysis device 1200, but also for other components within the enclosure 1300. With reference to Figure 21, the automatic seal 1700 can be positioned within the enclosure 1300 and the crane module 1430 can learn about the position. Petition 870260047759, dated 05 / 19 / 2026, page 148 / 317 137 / 143

[0760] According to an embodiment of the present disclosure, the autonomous preparation device 1100 may include a learning step for the position of the transport unit 1050. The learning consists of learning the position of the lifting module of the transport unit by the autonomous preparation device 1100 and, specifically, may learn the position of the reaction vessel 1500 accommodated on the analytical sample vessel shelf 1416 when the analytical sample vessel shelf 1416 of the lifting module 1410 is extended to its maximum in the horizontal direction to receive the reaction vessel 1500.

[0761] After the mechanical alignment between the lifting module 1410 and the autonomous analysis device 1200 is completed, as shown in Figure 24A, while the analytical sample vessel shelf 1416 of the lifting module 1410 is extended to its maximum, a gripper of a third transport module (not shown) of the preparation device 1100 can learn the position of the reaction vessel 1500 accommodated on the analytical sample vessel shelf 1416.

[0762] Figure 6 shows an enclosure according to an embodiment of the present disclosure.

[0763] The transport unit 1050 includes an enclosure 1300 and a transport device 1400. The transport device 1400 includes a lifting module 1410 and a crane module 1430.

[0764] The enclosure 1300 is used to spatially isolate molecular diagnostic devices supplied to the transport unit 1050 and may have the form of an enclosure, a cabinet, a box or similar. The enclosure 1300 may be configured as a table in which its front, rear, left, right and bottom portions are closed and at least one door is provided. The closure may have a form in which air or matter is completely prevented from entering, alternatively, and may be a closure in which air may enter in a controlled state through the vent hole. Petition 870260047759, dated 05 / 19 / 2026, page 149 / 317 138 / 143

[0765] The 1300 enclosure may include components for sample analysis within it. The 1300 enclosure has at least one port installed for component maintenance. The port is installed on the front / rear, left / right, etc. so that the user can access each component.

[0766] The enclosure 1300 includes a second defined passage 1310 through which a reaction vessel passes. The lifting module 1410 transports the reaction vessel through the second defined passage 1310.

[0767] The casing 1300 has a second defined passage (1 passage cavity) 1310 formed on its upper surface through which the lifting module 1410 passes which moves to the analysis device 1200 to receive the reaction vessel 1500.

[0768] Figure 7(b) is a perspective view illustrating a door device of the second passage defined 1310 according to an embodiment of the present disclosure. Figure 6 illustrates the closed form of the door portion 1311 of the second passage defined 1310.

[0769] The second defined passage 1310 can be formed on an upper surface of the enclosure 1300.

[0770] The second defined passage 1310 is formed to have a size through which pass a vertical motion guide 1413 included in the lifting module 1410 and an analytical sample vessel shelf 1416 which has capacity to accommodate the reaction vessel 1500.

[0771] In the present disclosure, the second defined passage 1310 can be formed to be vertically connected to the first defined passage 1130 formed in the self-contained preparation device 1100 located above the enclosure 1300. (see Figures 36A to 36C) Petition 870260047759, dated 05 / 19 / 2026, page 150 / 317 139 / 143

[0772] In one embodiment of the present disclosure, the second defined passage 1310 is a passage for moving the lifting module 1410 into the preparation device 1100.

[0773] In another embodiment of the present disclosure, the second defined passage 1310 is an open passage for moving the lifting module 1410 into the preparation device 1100, and, when the lifting module 1410 does not move into the preparation device 1100, the second open defined passage 1310 can be closed through the door part 1311 provided in the second defined passage 1310.

[0774] The gate part 1311 is provided to prevent, as much as possible, uncontrolled material from moving between the housing 1300 and the preparation device 1100. The analysis device 1200 may be located within the housing 1300, and the analysis device 1200 may produce a high concentration of an analyte in an analysis process. When such an analyte is diffused into the preparation device 1100 through the second defined passage 1310 and the first defined passage 1130, an error in the diagnostic result may occur. The gate part 1311 provided in the second defined passage 1310 can prevent the occurrence of an error due to such contamination.

[0775] Figure 35 is a view illustrating the interior of an enclosure 1300 in which a fan 1380 is disposed, which is an example of an environmental control means according to an embodiment of the present disclosure. The environmental control means 1380 controls the internal environment of the transport unit's enclosure 1300. The environmental control means 1380 serves to control the internal environment of the transport unit's enclosure 1300 to be the same environment as when the autonomous analysis device positioned inside the enclosure 1300 is not included in the assembly of the present disclosure and is used alone. Consequently, the same performance as when the autonomous device located in the enclosure Petition 870260047759, dated 05 / 19 / 2026, page 151 / 317 140 / 143 The 1300, when used alone, can be displayed. According to one embodiment, the means of environmental control may include a cooling and heating device, such as a fan, an air conditioner, a heating wire, and a lamp, and a control unit to control them. Figure 35 illustrates an enclosure 1300 in which four fans 1380-a, 1380-b, 1380-c, and 1380-d are arranged as means of environmental control. The four fans can be configured to be fully switched on or off by a power supply. The four alternate fans can be configured to operate selectively only some of the fans according to a change in the internal environment.

[0776] According to one embodiment, a duct to guide the air discharged by the fan may be additionally configured. Consequently, it is possible to prevent the air discharged by the fan from reaching the preparation device located at the top of the enclosure.

[0777] Figures 37A and 37B are perspective views of an analysis device 1200 according to an embodiment of the present disclosure. As shown in Figure 37B, at least one analysis device 1200 for receiving a sealed reaction vessel 1500 in an automatic sealer 1700 can be provided in an enclosure 1300. That is, with reference to Figure 37B, the interior of the enclosure 1300 of the transport unit 1050 is shown with two analysis devices 1200-a. 1200-b can be provided.

[0778] In one embodiment of the present disclosure, when two analytical devices are provided in the housing 1300, the preparation device 1100 sequentially prepares analytical samples for analysis. When the first reaction vessel is prepared in the preparation device 1100, the first reaction vessel can be moved to any analytical device in the housing 1300 to perform the analysis. Subsequently, when the second reaction vessel is prepared in the device of Petition 870260047759, dated 05 / 19 / 2026, page 152 / 317 141 / 143 preparation 1100, the second reaction vessel can be moved to another analysis device in the 1300 enclosure to perform the analysis.

[0779] Therefore, according to an embodiment of the present disclosure, the method of the present disclosure may include a learning step, by the transport unit 1050, of the position of each of the analysis devices 1200 when a plurality of analysis devices 1200 is provided.

[0780] The preparation device 1100 is a sample preparation device for preparing an analytical sample. Figures 36A to 36C illustrate the self-contained preparation device 1100 of the present disclosure and the alignment between the preparation device 1100 and the transport unit 1050.

[0781] The preparation device 1100 includes a platform 1110 that can hold various types of instruments and containers for preparing the analytical sample. The platform 1110 is formed in a shape in which the components included in the preparation device 1100 can be mounted and fixed.

[0782] In one embodiment of the present disclosure, the platform 1110 provides a guide for the components of the preparation device 1100 to be inserted into the preparation device 1100 in a sliding manner and positioned on top of the platform 1110.

[0783] The preparation device 1100 includes a housing 1190. The housing 1190 isolates the interior of the preparation device 1100 from the exterior. The housing 1190 is disposed on the upper surface, the lower surface, and the rear surface of the preparation device. The housing 1190 may be disposed on the front surface of the preparation device 1100. A door that can be opened, into which a sample or similar can be placed, may be formed in the housing on the front. The housing 1190 may be disposed on a left surface and a right surface of the preparation device 1100. Petition 870260047759, dated 05 / 19 / 2026, p. 153 / 317 142 / 143

[0784] According to one embodiment, a first defined passage 1130 is disposed on a lower surface of the housing 1190.

[0785] The first defined passage 1130 is a space in which the lifting module 1410 that moves from the housing 1300 is moved. The first defined passage 1130 is formed to correspond vertically to the second defined passage 1310 of the housing 1300. The first defined passage 1130 is formed to have a size in which the vertical movement guide 1413 and the analytical sample vessel shelf 1416 of the lifting module 1410 can be moved.

[0786] Figure 4 shows an assembly according to an embodiment of the present disclosure. As described above, in the assembly manufactured by the manufacturing method to provide and align the autonomous preparation device 1100 and the autonomous analysis device 1200 in the transport unit 1050 according to the present disclosure, a reaction vessel movement path can be formed between the autonomous preparation device 1100 and the autonomous analysis device 1200.

[0787] Specifically, the reaction vessel movement pathway may include the following steps.

[0788] (1) Transport of reaction vessel 1500 from preparation device 1100 to lifting module 1410; (2) transport of reaction vessel 1500 from inside preparation device 1100 to inside enclosure 1300 by lifting module 1410; and (3) transport of reaction vessel 1500 from lifting module 1410 to autonomous analysis device 1200 by crane module.

[0789] According to one embodiment, in the transport process of (3), the reaction vessel 1500 can be transported to the analysis device 1200 through the automatic seal 1700.

[0790] Additionally, the manufacturing method of the present disclosure can isolate the autonomous analysis device 1200 and the autonomous preparation device. Petition 870260047759, dated 05 / 19 / 2026, page 154 / 317 143 / 143 1100 through the positioning step of the autonomous analysis device 1200 in the housing 1300 of the transport unit 1050, thus avoiding the risk of analysis errors due to contamination.

Claims

1. Automated analysis system CHARACTERIZED in that it comprises: a preparation device for preparing an analysis sample in a reaction vessel; wherein the preparation device is a self-contained device; an analysis device for analyzing the analysis sample prepared in the reaction vessel; wherein the analysis device is a self-contained device; a transport device for transporting the reaction vessel; and an enclosure, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within the enclosure; wherein the preparation device and the enclosure each comprise a defined passage through which the reaction vessel is transported, and the transport device transports the reaction vessel through the defined passage; wherein the self-contained device is capable of operating independently when separated from the automated analysis system;wherein the transport device comprises a lifting module, and the lifting module is moved upwards to the preparation device to move the reaction vessel into the analysis device; and wherein the lifting module comprises a shelf guide configured to extend an analytical sample vessel shelf connected to the shelf guide in a horizontal direction for receiving the reaction vessel within the preparation device.

2. Automated analysis system, according to claim 1, CHARACTERIZED in that the enclosure encloses a single space, and the analysis device and the transport device are located in the single space. Petition 870260047759, dated 05 / 19 / 2026, p. 156 / 317 2 / 8 3. Automated analysis system, according to claim 1, CHARACTERIZED in that the preparation device and / or the analysis device is operationally connected to the housing.

4. Automated analysis system, according to claim 3, CHARACTERIZED in that the enclosure comprises positioning means capable of determining a position of the preparation device and / or the analysis device to be operationally connected.

5. Automated analysis system, according to claim 1, CHARACTERIZED in that it further comprises a control module capable of controlling the transport device.

6. Automated analysis system, according to claim 5, CHARACTERIZED in that the control module is connected to the preparation device, the analysis device and the transport device through a communication channel.

7. Automated analysis system, according to claim 6, CHARACTERIZED in that the control module provides an external signal necessary for the operation of the autonomous device.

8. Automated analysis system, according to claim 6, CHARACTERIZED in that the control module is configured to perform: receiving a signal indicating that the preparation of the analysis sample is completed in the preparation device through the communication channel; and providing a control signal to the transport device to transport the reaction vessel from the preparation device to the analysis device through the communication channel, so that the reaction vessel is transported from the preparation device to the analysis device.

9. Automated analysis system, according to claim 1, CHARACTERIZED in that the transport device comprises at least a robotic module configured to transport the reaction vessel from the preparation device to the analysis device.

10. Automated analysis system, according to claim 1, CHARACTERIZED in that the preparation device is configured to provide the defined passage through a pre-formed passage cavity.

11. Automated analysis system, according to claim 1, CHARACTERIZED in that the defined passage is formed with a door part that is opened when the reaction vessel is transported.

12. Automated analysis system, according to claim 1, CHARACTERIZED in that the preparation device is positioned above or below the analysis device.

13. Automated analysis system, according to claim 1, CHARACTERIZED in that the preparation device and the analysis device are powered by separate power sources and / or in that the preparation device and the analysis device are commercially available and / or approved as stand-alone devices.

14. Automated analysis system, according to claim 1, CHARACTERIZED in that it further comprises an automatic seal for sealing the upper surface of the reaction vessel.

15. Automated analysis system, according to claim 1, CHARACTERIZED in that the transport device comprises a crane module.

16. Automated analysis system, according to claim 5, CHARACTERIZED in that it further comprises: a door portion that opens and closes the defined passage; and a fan module that operates to discharge air from an internal space of the enclosure. Petition 870260047759, dated 05 / 19 / 2026, p. 158 / 317 4 / 8 17. Automated analysis system, according to claim 16, CHARACTERIZED in that it further comprises an automatic seal for sealing an unsealed reaction vessel, wherein the transport device receives the unsealed reaction vessel from the preparation device, transports the unsealed reaction vessel to the automatic seal, receives the sealed reaction vessel from the automatic seal and transports the sealed reaction vessel to the analysis device, and the control module interrupts the operation of the fan module from the moment the transport device receives the unsealed reaction vessel from the preparation device until the moment the transport device completes the transport of the sealed reaction vessel to the analysis device.

18. Method of analysis using an automated analysis system, the automated analysis system comprising a preparation device, an analysis device, a transport device, a control module and an enclosure, the method of analysis CHARACTERIZED in that it comprises: controlling, by the control module, the transport device so that a reaction vessel containing an analysis sample is transported from the preparation device to the analysis device; wherein the preparation device and the analysis device are autonomous devices; controlling, by the control module, the analysis device so that the analysis sample is analyzed in the analysis device; and controlling, by the control module, the transport device so that the reaction vessel in which the analysis of the analysis sample is completed is removed from the analysis device, Petition 870260047759, dated 05 / 19 / 2026, p.159 / 317 5 / 8 wherein at least one device selected from the group consisting of the analysis device and the transport device is located within an enclosure, the preparation device and the enclosure each comprise a defined passage through which the reaction vessel is transported, and the transport device transports the reaction vessel through the defined passage; wherein the transport device comprises a lifting module, and the lifting module is moved upwards to the preparation device to move the reaction vessel to the analysis device, wherein the lifting module comprises a shelf guide configured to extend an analytical sample vessel shelf connected to the shelf guide in a horizontal direction for receiving the reaction vessel within the preparation device.

19. An analytical method using an automated analytical system, according to claim 18, CHARACTERIZED in that it further comprises, before controlling the transport device to transport the reaction vessel to the analytical device, receiving, by the control module, a signal indicating that the preparation of the analytical sample is completed in the preparation device.

20. An analytical method using an automated analytical system, according to claim 18, CHARACTERIZED in that it further comprises, before the control of the transport device to remove the reaction vessel, receiving, by the control module, a signal indicating that the analysis of the sample is completed in the analytical device.

21. Non-transient computer-readable storage medium CHARACTERIZED by the fact that it contains instructions that, when executed by Petition 870260047759, dated 05 / 19 / 2026, page 160 / 317 6 / 8 one or more processors, cause an analysis method using an automated analysis system to be performed, wherein the automated analysis system comprises a preparation device, an analysis device, a transport device, a control module and an enclosure, and wherein the method comprises controlling, by the control module, the transport device so that a reaction vessel containing an analysis sample is transported from the preparation device to the analysis device; wherein the preparation device and the analysis device are autonomous devices; controlling, by the control module, the analysis device so that the analysis sample is analyzed in the analysis device;and control, by means of the control module, the transport device so that the reaction vessel in which the analysis of the sample is completed is removed from the analysis device, wherein at least one device selected from the group consisting of the analysis device and the transport device is located within an enclosure, the preparation device and the enclosure each comprise a defined passage through which the reaction vessel is transported, and the instructions comprise instructions that cause the transport device to perform the transport of the reaction vessel through the defined passage; wherein the transport device comprises a lifting module, and the lifting module is moved upwards to the preparation device to move the reaction vessel to the analysis device;and wherein the lifting module comprises a shelf guide configured to extend an analytical sample vessel shelf connected to the shelf guide in a horizontal direction for receiving the reaction vessel within the preparation device.

22. Method for controlling a fan module in an automated analysis system CHARACTERIZED in that the automated analysis system comprises: a preparation device for preparing an analysis sample in a reaction vessel, an analysis device for analyzing the prepared analysis sample in the reaction vessel, a transport device for transporting the reaction vessel, wherein the transport device comprises a lifting module, and the lifting module is moved upwards to the preparation device to move the reaction vessel to the analysis device;and wherein the lifting module comprises a shelf guide configured to extend an analytical sample vessel shelf connected to the shelf guide in a horizontal direction for receiving the reaction vessel within the preparation device, an enclosure, a door portion for opening and closing a defined passage, and a fan module that operates to discharge air from an internal space of the enclosure; wherein at least one device selected from the group consisting of the analytical device and the transport device is located within the enclosure; wherein the preparation device and the enclosure each comprise a defined passage through which the reaction vessel is transported; and wherein the method of controlling the fan module comprises: Petition 870260047759, dated 05 / 19 / 2026, page 162 / 317 8 / 8 opening the passage defined by the door portion;and interrupt a fan module operation while the defined passage is open through the door section.

23. Method for manufacturing an assembly of a molecular diagnostic device, wherein the assembly comprises a self-contained analytical device, a transport device, and a self-contained preparation device; wherein the transport device carries a reaction vessel and comprises a lifting module, wherein the lifting module is movable upwards to the preparation device to move the reaction vessel into the self-contained analytical device; and wherein the lifting module comprises a shelf guide configured to extend an analytical sample vessel shelf connected to the shelf guide in a horizontal direction for receiving the reaction vessel within the self-contained preparation device; the self-contained preparation device provides a reaction vessel containing a sample analyzable by the self-contained analytical device; the self-contained analytical device analyzes the sample contained in the reaction vessel;wherein the method is CHARACTERIZED by comprising the following steps: (a) providing the self-contained analysis device and the self-contained preparation device to the transport device; and (b) aligning the self-contained analysis device, the transport device and the self-contained preparation device, wherein the alignment forms a motion path for the reaction vessel between the self-contained preparation device and the self-contained analysis device.

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