VHH-BASED NKP46 LIGANDS
VHH antibody domains with high affinity for NKp46 enhance NK cell activation and cytotoxicity, addressing the limitations of existing ligands by improving specificity, stability, and manufacturability, effectively targeting tumor cells.
BR112025016337A2Pending Publication Date: 2026-07-07MERCK PATENT GMBH
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Patent Information
- Application Number
- BR112025016337
- Authority / Receiving Office
- BR · BR
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-02-06
- Filing Date
- 2024-02-05
- Publication Date
- 2026-07-07
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Abstract
The present disclosure relates to VHH-based NKp46 binders with favorable characteristics. Moreover, the present disclosure relates to pharmaceutical compositions comprising such a compound and the use of such compounds and such pharmaceutical compositions in medical treatment methods.
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