Bicyclic compounds active in terms of pesticides

Description

[0001] The present invention relates to a method of controlling animal pests, including arthropods and in particular insects or representatives of the order Hemiptera or Lepidoptera or representatives of the order Acarina, by using certain compounds having a bicyclic ring with 7 active members in terms of pesticides, in particular active in terms of insecticides. Additionally, the present invention also relates to certain compounds having a bicyclic ring with 7 active members in terms of pesticides, in particular active in terms of insecticides, to processes for their preparation, to compositions comprising these compounds and to their use for controlling animal pests, including arthropods and in particular insects or representatives of the order Lepidoptera or Hemiptera or representatives of the order Acarina.

[0002] WO2022 / 192224 describes certain bicyclic compounds for controlling invertebrate pests.

[0003] It has now been discovered that certain compounds having a bicyclic ring with 7 active members in pesticide terms are useful in controlling animal pests, including arthropods and in particular insects or representatives of the order Hemiptera or Lepidoptera or representatives of the order Acarina.

[0004] The present invention relates accordingly, in a first aspect, to a method for combating and controlling an animal pest to (i) reduce damage to a plant, comprising applying to the pest, to a locus of the pest or to a plant susceptible to attack by the pest an effective amount of any of the compounds of formula I or formula II; or Petition 870260073221, dated 07 / 23 / 2026, p. 7 / 259 2 / 240 (ii) protecting plant propagation material, which comprises treating the propagation material, or the location where the propagation material is planted, with an effective amount of either of the compounds of formula I or formula II; in which the compounds of the formula I II J X, regardless of whether it is formula I or II, is O, S, SO, SO2, SO(NH) or CH2; R1, R2, R3 and R4, regardless of whether they belong to formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; R5, R6 and R7, regardless of whether they belong to formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; Y is hydrogen, C1-C6-alkyl, C3-C6-alkenyl, C3C6-alkynyl, C3-C6-cycloalkyl-C1-C2-alkyl, aryl-C1-C2-alkyl or C1-C4-alkoxy-C1-C2-alkyl; Petition 870260073221, dated 07 / 23 / 2026, p. 8 / 259 3 / 240 J is hydrogen, alkyl-C1-Ce, alkenyl-Ca-Ce, alkynyl-CaCe or alkyl-C1-Ca substituted by a cycloalkyl-Ca-Ce, aryl, heteroaryl-C5-C1o or heterocyclyl-C4-C1o, whose alkyl-C1-Ce, alkenyl-Ca-Ce, alkynyl-Ca-Ce, independently of each other, can be substituted by ia 3 substituents, independently selected from Ra, whose cycloalkyl-Ca-Ce can be substituted by ia 3 substituents, independently selected from Rc, and whose aryl, heteroaryl-C5-C1o and heterocyclyl-C4-C1o can, independently of each other, be substituted by ia 4 substituents, independently selected from Rb; or J is aryl, heteroaryl-C5-Cio or heterocyclyl-C4-Cio, whose aryl, heteroaryl-C5-Cio and heterocyclyl-C4-Cio can independently be replaced by ia 4 substituents, independently selected from Rb; or J is alkyl-C1-C1-C(O), cycloalkyl-C1-C1-C(O), aryl-C(O), heteroaryl-C5-C10-C(O) or heterocyclyl-C4-C10-C(O), whose alkyl group can be substituted by substituents independently selected from R1, whose cycloalkyl group can be substituted by substituents independently selected from R1, and whose aryl, heteroaryl-C5-C10 and heterocyclyl-C4-C10 can independently be substituted by substituents independently selected from R1; or J is alkyl-C1-Ce-S(O)2, cycloalkyl-Ca-Ce-S(O)2, aryl-S(O)a, heteroaryl-C5-C10-S(O)2 or heterocyclyl-C4-C10-S(O)2, whose alkyl may be substituted by iaa substituents, independently selected from Ra, whose cycloalkyl may be substituted by iaa substituents, independently selected from Rc, and whose aryl, heteroaryl-C5-C10 and Petition 870260073221, dated 07 / 23 / 2026, p. 9 / 259 4 / 240 heterocyclyl-C4-C10 groups can independently be substituted by 1 to 4 substituents, independently selected from Re; or J is C1-C6 alkoxy, C3-C6 cycloalkyl-C1-C2 alkoxy, C1-C2 aryl alkoxy, C5-C10 heteroaryl-C1-C2 alkoxy or C4-C10 heterocyclyl-C1-C2 alkoxy, wherein the alkoxy may be substituted by 1 to 3 substituents, selected independently of Ra, wherein the cycloalkyl may be substituted by 1 to 3 substituents, selected independently of Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, selected independently of Rf; T is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C6 cycloalkyl, C1-C2 alkyl, C1-C2 aryl alkyl or C5-C10 heteroaryl, C1-C2 alkyl, whose alkyl, C3-C6 alkenyl, C3-C6 alkynyl may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl may independently be substituted by 1 to 4 substituents, independently selected from Rg; Ra, regardless of formula I or II, regardless of the substituent to which it is attached, is selected from halogen, cyano, and C1-C3 alkoxy; Rb, Rd, Re, Rf, Rg, regardless of formula I or II, and regardless of the substituent to which it is attached, is selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5 heteroaryl. Petition 870260073221, dated 23 / 07 / 2026, p. 10 / 259 5 / 240 C6 and heterocyclyl-C4-C10 (whose phenyl, phenoxy, heteroaryl and heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl); Rc, regardless of whether it is formula I or II, is selected from halogen, cyano, C1-C3 alkyl, and C1-C3 alkoxy; or an agrochemically acceptable salt, stereoisomer, tautomer and / or N-oxide of the compound of formula I or formula II.

[0005] It has now been further discovered that certain innovative derivatives of a 7-membered bicyclic ring provide improved control over these animal pests. Accordingly, a second aspect of the present invention relates to a compound of formula II or formula III, R1\ R5 V\ / R7r2^i ]\ / R3-^^ / \ Π R4 R / / 0 R\ R5 \ / °\ / R7r2^í ίκ / r3-J / \ A Π R4 R6 / / 0 where X, with respect to formula I, X, with respect to formula II or CH2; Y —N II, —O II-I is O, S, SO, SO2 or SO (NH); , is O, S, SO, SO2, SO(NH) Petition 870260073221, dated 07 / 23 / 2026, p. 11 / 259 6 / 240 R1, R2, R3 and R4, regardless of whether they belong to formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; R5, R6 and R7, regardless of whether they belong to formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; Y is hydrogen, C1-C6-alkyl, C3-C6-alkenyl, C3C6-alkynyl, C3-C6-cycloalkyl-C1-C2-alkyl, aryl-C1-C2-alkyl or C1-C4-alkoxy-C1-C2-alkyl; J is a C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, or C1-C2 alkyl substituted with a C3-C6 cycloalkyl, aryl, C5-C10 heteroaryl, or C4-C10 heterocyclyl, wherein the C1-C6 alkyl, C3-C6 alkenyl, or C3-C6 alkynyl groups can independently be substituted with 1 to 3 substituents independently selected from Ra, wherein the C3-C6 cycloalkyl groups can be substituted with 1 to 3 substituents independently selected from Rc, and wherein the C5-C10 aryl, heteroaryl, and C4-C10 heterocyclyl groups can independently be substituted with 1 to 4 substituents independently selected from Rb; or J is an aryl, heteroaryl-C5-C10, or heterocyclyl-C4-C10 group, whose aryl, heteroaryl-C5-C10, and heterocyclyl-C4-C10 groups can independently be substituted by 1 to 4 substituents, independently selected from Rb; or Petition 870260073221, dated 07 / 23 / 2026, p. 12 / 259 7 / 240 J is alkyl-C1-C6-C(O), cycloalkyl-C3-C6-C(O), aryl-C(O), heteroaryl-C5-C10-C(O) or heterocyclyl-C4-C10-C(O), whose alkyl can be substituted by 1 to 3 substituents, independently selected from R1, whose cycloalkyl can be substituted by 1 to 3 substituents, independently selected from R1, and whose aryl, heteroaryl-C5-C10 and heterocyclyl-C4-C10 can, independently of each other, be substituted by 1 to 4 substituents, independently selected from R1; or J is C1-C6-S(O)2 alkyl, C3-C6-S(O)2 cycloalkyl, S(O)2 aryl, C5-C10-S(O)2 heteroaryl or C4-C10-S(O)2 heterocyclyl, wherein the alkyl can be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl can be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl can, independently of each other, be substituted by 1 to 4 substituents, independently selected from Re; or J is C1-C6 alkoxy, C3-C6 cycloalkyl-C1-C2 alkoxy, C1-C2 aryl alkoxy, C5-C10 heteroaryl-C1-C2 alkoxy or C4-C10 heterocyclyl-C1-C2 alkoxy, wherein the alkoxy may be substituted by 1 to 3 substituents, selected independently of Ra, wherein the cycloalkyl may be substituted by 1 to 3 substituents, selected independently of Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, selected independently of Rf; T is hydrogen, C1-C6-alkyl, C3-C4 alkenyl, C3C4-alkynyl, C3-C6-cycloalkyl-C1-C2-alkyl, aryl-C1-C2-alkyl or heteroaryl-C5-C10-C1-C2-alkyl, which alkyl, alkenyl Petition 870260073221, dated 07 / 23 / 2026, p. 13 / 259 8 / 240 C3-C4 and C3-C4 alkynyl groups, independently of each other, may be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl groups may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rg; Ra, regardless of formula I or II, regardless of the substituent to which it is attached, is selected from halogen, cyano, and C1-C3 alkoxy; Rb, Rd, Re, Rf, and Rg, regardless of whether it is formula I or II, and regardless of the substituent to which it is attached, is selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C4 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl, and C4-C10 heterocyclyl (whose phenyl, phenoxy, heteroaryl, and heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano, and C1-C3 alkyl); Rc, regardless of whether it is formula I or II, is selected from halogen, cyano, C1-C3 alkyl, and C1-C3 alkoxy; provided that, when X is CH2 in formula II, T is not hydrogen, C1-C4 alkyl, 2-fluoroethyl, 2-methyl-4-pyrimidinyl)methyl, 2-(methylsulfonyl)phenyl]methyl, 2,6-di(tert-butyl)-4-methylphenyl, 1,4-dihydro-6-methyl-4-oxo-3-pyridazinyl)methyl, 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl, or tetrahydro-4,4-dimethyl-2-oxo-3-furanyl; or, when X is O in formula II, T is not hydrogen or C1-C2 alkyl; or an agronomically acceptable salt, stereoisomer, tautomer and / or N-oxide of the compound of formula II or formula II-I. Petition 870260073221, dated 07 / 23 / 2026, p. 14 / 259 9 / 240

[0006] The compounds of formulas I and II (correspondingly II and II-I) that have at least one basic center can form, for example, addition salts of acids, for example with strong inorganic acids such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphoric acid or a hydrohalic acid, with strong organic carboxylic acids, such as C1-C4 alkane carboxylic acids that are unsubstituted or substituted, for example by halogen, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, for example oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid, such as hydroxycarboxylic acids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or such as benzoic acid, or with organic sulfonic acids, such as alkane- or unsubstituted or substituted C1-C4 aryl sulfonyl compoundsFor example, by halogen, for example methane- or p-toluenesulfonic acid. Compounds of formulas I and II that have at least one acid group can form, for example, salts with bases, for example mineral salts such as salts of alkali metals or alkaline earth metals, for example, sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or trialkyl-inferioramine, for example ethyl-, diethyl-, triethyl or dimethylpropylamine, or a mono-, di- or trihydroxyalkyl-inferioramine, for example mono-, di- or triethanolamine. Petition 870260073221, dated 07 / 23 / 2026, page 15 / 259 10 / 240

[0007] N-oxides are oxidized forms of tertiary amines or oxidized forms of nitrogen-containing heteroaryl compounds. They are described, for example, in the book Heterocyclic N-oxides by A. Albini and S. Pietra, CRC Press, Boca Raton 1991.

[0008] In each case, the compounds of formula I or II according to the invention are in free form, in oxidized form as an N-oxide or in salt form, e.g. an agronomically usable salt form.

[0009] The compounds of formula I or II according to the invention also include hydrates that may be formed during the formation of salts.

[0010] The term C1-Cn alkyl as used here refers to a saturated alkyl group, for example, any of the methyl and ethyl radicals.

[0011] The term alkenyl-C2—Cn as used herein refers to a linear or branched alkenyl chain having two carbon atoms and one or two double bonds, for example, ethenyl, prop-1-enyl, but-2-enyl.

[0012] The term “C2—Cn” alkynyl as used herein refers to a linear or branched alkynyl chain having two carbon atoms and a triple bond, for example, ethinyl, prop-2-ynyl, but-3-ynyl.

[0013] The term C3-Cn cycloalkyl as used herein refers to cycloalkyl groups with 3-n members such as cyclopropane and cyclobutane.

[0014] The term alkoxy-C1-Cn as used here refers to a saturated linear or branched chain alkyl radical having 1 carbon atom (as mentioned above) that is attached through an oxygen atom, i.e., by Petition 870260073221, dated 07 / 23 / 2026, p. 16 / 259 11 / 240 example, any of the methoxy and ethoxy radicals. The term haloalkoxy-C1-Cn as used here refers to a C1-Cn alkoxy radical where one or more hydrogen atoms in the alkyl radical are replaced by the same halo atom(s) or different halo atom(s) - examples include trifluoromethoxy, difluoromethoxy, fluoromethoxy or 2-fluoroethoxy.

[0015] Halogen is generally fluorine, chlorine, bromine, or iodine. This also applies, correspondingly, to halogen in combination with other meanings, such as haloalkyl.

[0016] The term haloalkyl-C1-Cn as used herein refers to a saturated linear chain alkyl radical attached through any of the carbon atoms having 1-an carbon atoms (as mentioned above), wherein some or all of the hydrogen atoms in these radicals may be substituted by fluorine, chlorine, bromine and / or iodine, i.e., for example, any of chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl or pentafluoroethyl.Accordingly, a C1-C2 fluoroalkyl term would refer to a C1-C2 alkyl radical carrying 1, 2, 3, 4, or 5 fluorine atoms, for example, any of difluoromethyl, trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, or pentafluoroethyl. Petition 870260073221, dated 07 / 23 / 2026, p. 17 / 259 12 / 240

[0017] The term alkoxy-Ci-Cn-alkyl-Ci-Cn as used herein refers to an alkyl radical substituted by an alkoxy-Ci-Cn group. Examples are methoxymethyl, methoxyethyl, and ethoxymethyl.

[0018] The term alkyl-Ci-Cn-C(O) refers to a substituent having an alkyl group attached to a C(=O) moiety, which moiety is connecting to the rest of the compound through its carbon atom. Examples include CH3C(O) and isopropylC(O). The terms aryl-C(O), heteroaryl-Cõ-CnC(O), and heterocyclyl-C4-Cn-C(O) refer correspondingly to aryl, heteroaryl-C5-Cn, and heterocyclyl-C4-Cn groups, respectively, attached to a C(=O) moiety, which moiety, in each case, is connecting to the rest of the compound through its carbon atom.

[0019] The term alkyl-Ci-Cn-S(O)2 refers to a substituent having an alkyl group attached to a fraction of S(=O)2, which fraction is connecting to the rest of the compound through its sulfur atom. The terms aryl-S(O)2, heteroaryl-C5-Cn-S(O)2 and heterocyclyl-C4-Cn-S(O)2 refer correspondingly to aryl, heteroaryl-C5Cn and heterocyclyl-C4-Cn groups, respectively, attached to a fraction of S(=O)2, which fraction, in each case, is connecting to the rest of the compound through its sulfur atom.

[0020] The term cycloalkyl-Cs-Cn-alkoxy-Ci-Cm refers to a substituent having a cycloalkyl group having 3 an number of carbon atoms bonded to the carbon atom of an alkoxy moiety having 1 am carbon atoms, which moiety is connecting to the rest of the compound through its oxygen atom. The terms aryl-alkoxy-Ci-Cm, Petition 870260073221, dated 07 / 23 / 2026, p. 18 / 259 13 / 240 heteroaryl-C5-Cn-alkoxy-C1-Cm and heterocyclyl-C4-Cn-alkoxy-C1-Cm refer correspondingly to aryl groups, heteroaryl-C5-Cn and heterocyclyl-C4-Cn, respectively, which are attached to the carbon atom of an alkoxy moiety having 1 am carbon atoms, which moiety is connecting to the rest of the compound through its oxygen atom.

[0021] The term alkyl-Ci-Cnsulfanyl or alkyl-CiCntio” as used herein refers to an alkyl-CiCn moiety linked through a sulfur atom. Similarly, the term haloalkyl-Ci-Cntio” or haloalkyl-Ci-Cnsulfanyl as used herein refers to a haloalkyl-Ci-Cn moiety linked through a sulfur atom.

[0022] The term Ci-Cnsulfinyl alkyl as used herein refers to a Ci-Cn alkyl moiety linked through the sulfur atom of the S(=O) group. Similarly, the term haloalkyl-Ci-Cnsulfinyl or haloalkyl-Ci-Cnsulfinyl as used herein refers to a haloalkyl-Ci-Cn moiety linked through the sulfur atom of the S(=O) group.

[0023] The term alkyl-Ci-Cnsulfonyl as used herein refers to an alkyl-Ci-Cn moiety linked through the sulfur atom of the S(=O)2 group. Similarly, the term haloalkyl-Ci-Cnsulfonyl or haloalkyl-Ci-Cnsulfonyl as used herein refers to an alkyl-Ci-Cn moiety linked through the sulfur atom of the S(=O)2 group.

[0024] The term “aryl” as used herein refers to a mono-, bi-, or tricyclic carbocyclic ring that is fully unsaturated. Examples of such substituents include phenyl, naphthalenyl, anthracenyl, indenyl, or phenanthrenyl. The term “aryl-Cq-Cn” refers to a mono- or bi-carbocyclic ring with qan members. Examples are phenyl (or Ja) and naphthalenyl. Petition 870260073221, dated 07 / 23 / 2026, p. 19 / 259 14 / 240

[0025] The term heterocyclyl-C4-Cn refers to a co-, 4-membered heterocyclic ring. Examples are Ka to Kbd in Scheme 3.

[0026] The term heteroaryl-C5-Cn as used here refers to a heterocyclic ring with 5 an members that is totally unsaturated. In the case of a heteroaryl ring being bicyclic, then at least one of the ring is totally unsaturated. Examples are illustrated in Schemes 1 and 2. In the case of a heteroaryl ring being substituted, the substituent may be on the carbon atom in the ring skeleton and / or a heteroatom in the ring skeleton, such as N.

[0027] The term “7-membered bicyclic ring” as used herein with respect to formula I or formula II refers to a bicyclic ring consisting of 7 ring atoms in its skeleton, which is composed of a 6-membered saturated heterocyclic ring and a 3-membered saturated carbocyclic ring, as illustrated in the figure below, where D can be CH2, S, SO, SO2, SO(NH) or O.

[0028] The term “carbocyclic ring” as used herein refers to a ring of atoms in which the ring skeleton is formed solely of carbon. The ring may be a monocyclic ring or a fused bicyclic ring. One or more carbon ring members may be present as a C(=O), C(=S), C(NH) or C(NOR) moiety in the ring (where R is hydrogen, C1-C3 alkyl, C5-C6-CH2 aryl or Cs-Ce-Cfc heteroaryl). The ring may be saturated or partially unsaturated. Petition 870260073221, dated 07 / 23 / 2026, page 20 / 259 15 / 240

[0029] The term “heterocyclic ring” as used herein refers to a carbocyclic ring in which at least one ring member forming the ring skeleton is not carbon, e.g., is selected from nitrogen, oxygen, and sulfur. The ring may be a monocyclic ring or a fused bicyclic ring. Typically, a heterocyclic ring contains no more than 4 nitrogens, no more than 2 oxygens, and no more than 2 sulfurs. One or more carbon ring members may be present as a C(=O), C(=S), C(NH), or C(NOR) moiety in the ring (where R is hydrogen, alkyl-C1-C3, aryl-C5-C6-CH2, or heteroaryl-C5-C6-CH2). One or more S ring members may be present as an S(=O), S(=O)2, or S(=ONH) moiety in the ring. The ring may be saturated or partially unsaturated. Examples are illustrated in Scheme 3. In the case of a substituted heterocyclic ring, the substituent may be on the carbon atom in the ring skeleton and / or a heteroatom in the ring skeleton, such as N.

[0030] As used herein, the term control refers to reducing the number of pests, eliminating pests and / or preventing further damage from pests such that damage to a plant or a plant-derived product is reduced.

[0031] As used herein, the term pest refers to insects and mollusks that are found in agriculture, horticulture, forestry, in the storage of plant products (such as fruit, grain and wood); and those pests associated with damage to man-made structures. The term pest encompasses all stages of the pest's life cycle.

[0032] Examples of heteroaromatic with 5 or 6 members refers to an aromatic ring with 5 or 6 members having 1 to 3 Petition 870260073221, dated 07 / 23 / 2026, p. 21 / 259 16 / 240 carbon atoms independently substituted with nitrogen, sulfur, or oxygen. Examples are pyridyl (or pyridinyl), pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl (e.g., 1,2,4 triazolyl), furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, and thiadiazolyl.

[0033] Examples of “9- or 10-membered heteroaromatic” refers to a 9- or 10-membered aromatic ring consisting of two rings, having 1 to 4 carbon atoms independently substituted with nitrogen, sulfur, or oxygen (the heteroatoms may be in one ring or distributed between the two). Examples are purinyl, quinolinyl, cinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, imidazo[1,2a]pyridinyl, and imidazo[4,5b]pyridinyl.

[0034] The chemical abbreviations SO2, S(O)2 and S(=O)2 as used herein represent a sulfonyl moiety. The chemical abbreviations C(O) and C(=O) as used herein represent a carbonyl moiety. The chemical abbreviations CO2, C(O)O and C(=O)O as used herein represent an oxycarbonyl moiety. “CHO” stands for formyl.

[0035] As used herein, “animal pest” refers to a pest that is harmful, causing damage, affecting the growth and / or health of a plant or animal. Examples of such pests may be from the phyla Nematoda, Arthropoda, and Mollusca.

[0036] As used herein, the term “effective amount” refers to the amount of the compound, or a salt thereof, which, after single or multiple applications, provides the desired effect. Petition 870260073221, dated 07 / 23 / 2026, p. 22 / 259 17 / 240

[0037] As used herein, the term pesticide refers to a substance or composition used to control or destroy an animal pest that is harmful to plants or crops (especially cultivated plants or crops) or to animals.

[0038] The dashed line as used here, for example, in J1 to J57, represents the connection / attachment point to the rest of the compound.

[0039] An effective amount is readily determined by an expert in the art, by the use of known techniques and by observation of the results obtained under analogous circumstances. In determining the effective amount, a number of factors are considered including, but not limited to: the type of plant or derived product to be applied; the pest to be controlled and its life cycle; the particular compound applied; the type of application; and other relevant circumstances.

[0040] The molecular illustrations drawn here follow standard conventions for illustrating stereochemistry. To indicate stereoconfiguration, bonds rising from the plane of the drawing and toward the viewer are denoted by solid wedges where the wide end of the wedge is attached to the atom rising from the plane of the drawing toward the viewer. Bonds going below the plane of the drawing and away from the viewer are denoted by dashed wedges where the wide end of the wedge is attached to the atom furthest from the viewer.

[0041] The compounds of the invention can exist as stereoisomers due to chiral carbon atoms. Petition 870260073221, dated 07 / 23 / 2026, p. 23 / 259 18 / 240 present in formulas I and II. Thus, the present invention comprises the individual stereoisomers of the compounds of formulas I or II, as well as mixtures of stereoisomers of the compounds of formulas I or II.

[0042] The compounds of formulas I and II (and correspondingly formulas II and II-I) may be present as a mixture of stereoisomers or individual stereoisomers. For example, four possible stereoisomers of formula I are illustrated below as formulas Ia, Ib, Ic, and Id, involving the three chiral centers of cyclopropane identified with asterisks (*); and the four possible stereoisomers of formula II are illustrated as formulas IIa, IIb, IIc, and IId (in each case where X is CH2, S, SO, SO2, or SO(NH). An expert would understand that other chiral centers are also an example, R1. Selection of stereoisomers of the formula IR\ / r1\ * r7 \ R----· / R2---n X R-__ XX / R-__ / *\ „ TF \ / R4 R / / J R4 O Ia R1\ R5 R\ \ X / R7 \ / °x RX^ / Y R-~-~— r3—__ s'*'·. J R--——_ / x *\f- 7 / \ J xx R4 R / / JR 0 Ic where X is CH2, S, SO, SO2 or SO(NH); and R1, R7, Y and J are as defined herein. Petition 870260073221, dated 07 / 23 / 2026, p. 24 / 259 19 / 240 IIa IIc IIb where X is CH2, S, SO, SO2 or SO(NH); and R1, R2, R3, R4, R5, R6, R7e T are as defined here.

[0043] The present invention comprises diastereomeric mixtures of equal amounts of the single diastereomers. Additionally, the present invention includes mixtures that are enriched in one of the enantiomers compared to racemic mixtures. The invention also comprises an essentially pure enantiomer.

[0044] In the case of compounds of formula I and formula II where X = O, two possible stereoisomers of formula I are illustrated below as formulas Iaa and Icc, describing the relative orientation of the carbon identified with asterisks (*); and the two possible stereoisomers of formula II are illustrated as formulas IIaa and IIcc. An expert would understand that other chiral centers are also possible in, for example, R1. Selection of stereoisomers of formula I Petition 870260073221, dated 07 / 23 / 2026, p. 25 / 259 20 / 240 J R3 J laa Icc where R1, R2 R4 R5, R6 R7são as defined here. Selection of stereoisomers of formula II IIaa IIcc where R1 R2 R3 R4 R5 R6, R7, Y, and J are as defined here.

[0045] Compounds of formula I or II may include additional chiral centers. For example, substituents and other molecular constituents such as J (in the case of formula II). I) or T (in the case of formula II) may themselves contain chiral centers. The invention comprises racemic mixtures as well as enriched and essentially pure stereoconfigurations in these additional chiral centers.

[0046] The compounds of the invention may exist as one or more conformational isomers due to restricted rotation around an amide linkage (e.g., C(=O)-N) in the formula I or II. The invention comprises mixtures of conformational isomers. Additionally, the invention includes compounds that are enriched in one conformer relative to others.

[0047] The invention comprises all stereoisomers, conformational isomers and mixtures thereof in all proportions, as well as isotopic forms such as deuterated compounds. Petition 870260073221, dated 07 / 23 / 2026, page 26 / 259 21 / 240

[0048] Compounds of formula I or II, stereoisomers, tautomers, N-oxides and salts thereof typically exist in more than one form, and thus compounds of formula I or II include all crystalline and non-crystalline forms of the compounds that formula I or II respectively represent. Non-crystalline forms include modalities that are solids such as waxes and gums as well as modalities that are liquids such as solutions and melts. Crystalline forms include modalities that essentially represent a single crystal type and modalities that represent a mixture of polymorphs (i.e., different crystalline types). The term polymorph refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and / or conformations of the molecules in the crystal lattice.Although polymorphs may have the same chemical composition, they may also differ in composition due to the presence or absence of co-crystallized water or other molecules, which may be weakly or strongly bound in the network. Polymorphs may differ in such chemical, physical, and biological properties as shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate, and bioavailability of the crystals. A person skilled in the art will understand that a polymorph of a compound represented by formula I or II may exhibit beneficial effects (e.g., suitability for preparing useful formulations, improved biological performance) compared to another polymorph or a mixture of polymorphs of the same compound of formula I or II, respectively. A. Petition 870260073221, dated 07 / 23 / 2026, page 27 / 259 22 / 240 Preparation and isolation of a particular polymorph of a compound of formula I or II can be achieved by methods known to those skilled in the art, including, for example, crystallization using selected solvents and temperatures. The compounds of the invention may exist as one or more crystalline polymorphs. The invention comprises both individual polymorphs and mixtures of polymorphs, including mixtures enriched in one polymorph relative to others. For a comprehensive discussion of polymorphism, see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006. A person skilled in the art would understand that the comments regarding formula I in this paragraph apply equally to a compound of formula II.

[0049] Embodiments according to the invention are provided as presented below.

[0050] In one embodiment of each aspect of the invention, the present invention relates to a compound of formula I.

[0051] In one embodiment of each aspect of the invention, a compound of formula I (when X is CH2, S, SO, SO2 or SO(NH)) is a A. A mixture of compounds of formulas Ia and Ib, where the ratio between Ia and Ib is at least 75:25 (an enantiomeric excess of 50 percent by weight of Ia); or B. a mixture of compounds of formulas Ia and Ib, where the ratio between Ia and Ib is at least 90:10 (an enantiomeric excess of 80 percent by weight of Ia); or C. a mixture of compounds of formulas Ia and Ib, where the ratio between Ia and Ib is at least 95:5 (an enantiomeric excess of 90 percent by weight of Ia); or Petition 870260073221, dated 07 / 23 / 2026, p. 28 / 259 23 / 240 D. a mixture of compounds of formulas Ia and Ib, where the ratio between Ia and Ib is at least 98:2 (an enantiomeric excess of 96 percent by weight of Ia); or E. a mixture of compounds of formulas Ia and Ib, where the ratio between Ia and Ib is at least 99:1 (an enantiomeric excess of 98 percent by weight of Ia); or F. a compound of formula Ia.

[0052] In one embodiment of each aspect of the invention, a compound of formula I (when X is O) is a G. a mixture of compounds with formulas Iaa and Icc, where the ratio between Iaa and Icc is at least 75:25 (an enantiomeric excess of 50 percent by weight of Iaa); or H. mixture of compounds of formulas Iaa and Icc, where the ratio between Iaa and Icc is at least 90:10 (an enantiomeric excess of 80 percent, by weight, of Iaa); or I. a mixture of compounds with formulas Iaa and Icc, where the ratio between Iaa and Icc is at least 95:5 (an enantiomeric excess of 90 percent by weight of Iaa); or J. mixture of compounds of formulas Iaa and Icc, where the ratio between Iaa and Icc is at least 98:2 (an enantiomeric excess of 96 percent by weight of Iaa); or K. mixture of compounds of formulas Iaa and Icc, where the ratio between Iaa and Icc is at least 99:1 (an enantiomeric excess of 98 percent of Iaa); or L. a compound with the formula Iaa.

[0053] In one embodiment of each aspect of the invention (excluding the second aspect), X in formula I is A. X is O, S, SO, SO2, CH2 or SO(NH); or B. X is O, S, SO, SO2 or SO(NH); or C. X is O, S, SO or SO2, or Petition 870260073221, dated 07 / 23 / 2026, p. 29 / 259 24 / 240 D. X is O.

[0054] In a second aspect modality, X in formula I is A. X is O, S, SO, SO2 or SO(NH); or B. X is O.

[0055] In one embodiment of each aspect of the invention, the present invention relates to a compound of formula II

[0056] In one embodiment of each aspect of the invention, X in formula II is A. X is O, S, SO, SO2, CH2 or SO(NH); or B. X is O, S, SO, SO2 or SO(NH); or C. X is O, S, SO or SO2, or D. X is O.

[0057] In one embodiment of each aspect of the invention, a compound of formula II (when X is CH2, S, SO, SO2 or SO(NH)) is a A. A mixture of compounds of formulas IIa and IIb, where the ratio between IIa and IIb is at least 75:25 (an enantiomeric excess of 50 percent by weight of IIa); or B. a mixture of compounds of formulas IIa and IIb, where the ratio between IIa and IIb is at least 90:10 (an enantiomeric excess of 80 percent by weight of IIa); or C. a mixture of compounds of formulas IIa and IIb, where the ratio between IIa and IIb is at least 95:5 (an enantiomeric excess of 90 percent by weight of IIa); or D. a mixture of compounds of formulas IIa and IIb, where the ratio between IIa and IIb is at least 98:2 (an enantiomeric excess of 96 percent by weight of IIa); or Petition 870260073221, dated 07 / 23 / 2026, p. 30 / 259 25 / 240 E. a mixture of compounds of formulas IIa and IIb, where the ratio between IIa and IIb is at least 99:1 (an enantiomeric excess of 98 percent of IIa); or F. a compound of formula IIa.

[0058] In one embodiment of each aspect of the invention, a compound of formula II (when X is CH2) comprises A. A mixture of compounds with formulas IIaa and IIcc, where the ratio between IIaa and IIcc is at least 75:25 (an enantiomeric excess of 50 percent by weight of IIaa); or B. a mixture of compounds of formulas IIaa and IIcc, where the ratio between IIaa and IIcc is at least 90:10 (an enantiomeric excess of 80 percent by weight of IIaa); or C. a mixture of compounds with formulas IIac and IIcc, where the ratio between IIac and IIcc is at least 95:5 (an enantiomeric excess of 90 percent by weight of IIaa); or A. A mixture of compounds with formulas IIaa and IIcc, where the ratio between IIaa and IIcc is at least 98:2 (an enantiomeric excess of 96 percent by weight of IIaa); or E. a mixture of compounds with formulas IIaa and IIcc, where the ratio between IIaa and IIcc is at least 99:1 (an enantiomeric excess of 98 percent of IIaa); or F. a compound of formula IIaa.

[0059] In one embodiment of each aspect of the invention, R1, R2, R3 and R4, are A. hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy; or B. hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy; or C. hydrogen, halogen, cyano, C1-C4 alkyl or C1-C4 haloalkyl; or Petition 870260073221, dated 07 / 23 / 2026, page 31 / 259 26 / 240 D. hydrogen, chlorine, fluorine, bromine, iodine, cyano, methyl, ethyl, isopropyl, trifluoromethyl or difluoromethyl; or E. hydrogen, chlorine, fluorine, methyl, trifluoromethyl or difluoromethyl; or F. hydrogen.

[0060] In one embodiment of each aspect of the invention, R5, R6 and R7, are A. hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy; or B. hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy; or C. hydrogen, halogen, cyano, C1-C4 alkyl or C1-C4 haloalkyl; D. hydrogen, chlorine, fluorine, bromine, iodine, cyano, methyl, ethyl, isopropyl, trifluoromethyl or difluoromethyl; or E. hydrogen, chlorine, fluorine, methyl, trifluoromethyl or difluoromethyl; or F. hydrogen.

[0061] In one embodiment of each aspect of the invention, Y is A. is hydrogen, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C6-CH2 cycloalkyl, CH2 aryl, or C1-C4CH2 alkoxy; or B. is hydrogen, methyl, ethyl, isopropyl, allyl, propargyl, cyclopropylmethyl, benzyl, methoxymethyl or ethoxymethyl; or C. is hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl, or methoxymethyl; or D. hydrogen. Petition 870260073221, dated 07 / 23 / 2026, page 32 / 259 27 / 240

[0062] In one embodiment of each aspect of the invention, J is A. hydrogen, C1-C4 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C4-CH2CH2 cycloalkyl, C3-C4-CH2 cycloalkyl, CH2CH2 aryl, CH2 aryl, C5-C10-CH2CH2 heteroaryl, C5-C10-CH2 heteroaryl, C4-C10-CH2 heterocyclyl or C4-C10-CH2CH2 heterocyclyl, whose C1-C4 alkyl, C3-C4 alkenyl and C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl groups may be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl groups They can, independently of each other, be replaced by 1 to 4 substituents, independently selected from Rb; B. hydrogen, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C4-CH2 cycloalkyl, C5-C6-CH2 aryl, C9-C10-CH2 aryl, C5-C6-CH2 heteroaryl, C9-C10-CH2 heteroaryl, C4-C6-CH2 heterocyclyl or C9-C10-CH2 heterocyclyl, whose C1-C4 alkyl, C3-C4 alkenyl and C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl groups may be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, heteroaryl and heterocyclyl groups may independently be substituted by 1 to 4 substituents, independently selected from Rb; or C. hydrogen, C1-C4-alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C4-cycloalkyl-CH2, C5-C6-CH2 aryl, C9-aryl Petition 870260073221, dated 07 / 23 / 2026, page 33 / 259 28 / 240 C10-CH2, heteroaryl-C5-C6-CH2, heteroaryl-C9-C10-CH2, heterocyclyl-C4-C6-CH2 or heterocyclyl-C9-C10-CH2, whose alkyl-C1-C4, alkenyl-C3-C4 and alkynyl-C3-C4 groups may independently be substituted by 1 to 3 substituents, independently selected from Rc, whose cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, heteroaryl and heterocyclyl groups may independently be substituted by 1 to 4 substituents, independently selected from Rb; or D. hydrogen, C1-C3 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C4-CH2 cycloalkyl, Ja-CH2 to Jdl-CH2, Ka-CH2 to Kbd-CH2, Ja-CH2CH2 to Jdl-CH2CH2, Ka-CH2CH2 to Kbd-CH2CH2, whose C1-C3 alkyl, C3-C4 alkenyl and C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl groups may be substituted by 1 to 3 substituents, independently selected from Rc, and whose Ja to Jdl and Ka to Kbd rings may independently be substituted by 1 to 4 substituents, independently selected from Rb; or E. hydrogen, C1-C3-alkyl, C3-C4 alkenyl, C3-C4 alkynyl, cyclopropylmethyl, Ja-CH2 to Jdl-CH2, Ka-CH2 to KbdCH2, Ja-CH2CH2 to Jdl-CH2CH2 or Ka-CH2CH2 to Kbd-CH2CH2, of which C1-C3 alkyl, C3-C4 alkenyl and C3-C4-alkynyl, independently of each other, can be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, whose cyclopropyl can Petition 870260073221, dated 07 / 23 / 2026, p. 34 / 259 29 / 240 may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose rings Ja to Jdl and Ka to Kbd may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and alkyl-C1-C3); or F. hydrogen, C1-C3 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, cyclopropylmethyl, Ja-CH2 to Jdl-CH2, Ka-CH2 to KbdCH2, Ja-CH2CH2 to Jdl-CH2CH2 or Ka-CH2CH2 to Kbd-CH2CH2, whose C1-C3 alkyl, C3-C4 alkenyl and C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine and methoxy, whose cyclopropyl group may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine, methyl and methoxy, and whose Ja to Jdl and Ka to Kbd rings may independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, iso-propyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (which phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6, Petition 870260073221, dated 07 / 23 / 2026, page 35 / 259 30 / 240 independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or G. hydrogen, methyl, ethyl, isopropyl, allyl, propargyl, cyclopropylmethyl, Ja-CH2, Ja-CH2CH2 to JdlCH2CH2 or Ka-CH2CH2 to Kbd-CH2CH2, whose methyl, ethyl, isopropyl, allyl and propargyl groups may independently be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano, and methoxy groups, whose cyclopropyl group may be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano, methyl and methoxy groups, and whose Ja to Jdl and Ka to Kbd rings may independently be substituted by 1 to 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, isopropyl, methoxy groups, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Ja to Jbn and Ka to Kbd (whose phenoxy rings Ja to Jbn or Ka to Kbd, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or H. hydrogen, methyl, cyclopropylmethyl, Ja-CH2, JaCH2CH2 to Jdl-CH2CH2 or Ka-CH2CH2 to Kbd-CH2CH2, wherein the methyl group may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, and methoxy, wherein the cyclopropyl group may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and wherein the rings Ja to Jdl and Ka to Kbd may, independently of each other, Petition 870260073221, dated 07 / 23 / 2026, page 36 / 259 31 / 240 being substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, isopropyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Ja to Jbn and Ka to Kbd (whose phenoxy rings Ja to Jbn or Ka to Kbd, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or I. hydrogen, Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose J rings can independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, isopropyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Ja to Jbn and Ka to Kbd (whose phenoxy rings Ja to Jbn or Ka to Kbd can independently be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0063] In one embodiment of each aspect of the invention, J is A. aryl-C5-C6, aryl-C9-C10, heteroaryl-C5-C6, heteroaryl-C9-C10, heterocyclyl-C4-C6 or heterocyclyl-C9-C10, whose aryl, heteroaryl and heterocyclyl groups can independently be substituted by 1 to 4 substituents, independently selected from Rb; or B. Ja a Jdl or Ka a Kbd, whose Ja a Jdl and Ka a Kbd rings can independently be replaced by 1 to 4 substituents, independently selected from Rb; or Petition 870260073221, dated 07 / 23 / 2026, p. 37 / 259 32 / 240 C. Ja, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc or Kbd, whose J rings and K rings can independently be replaced by 1 to 4 substituents independently selected from Rb; or D. Ja, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc or Kbd, whose J rings and K rings can independently be substituted by 1 to 4 substituents independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NHaC(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl groups; or E. Ja, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc or Kbd, whose J rings and K rings can, independently of each other, be replaced by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3-alkyl, C1-C3-alkoxy, NH2C(O), (C1-C3-alkyl)N(H)C(O), NH2C(O)C1-C3-alkoxy (C1-C3-alkyl)SO2, benzyl, phenyl, phenoxy, Ja to Jbl and Ka to Kbd (whose benzyl, phenoxy, Ja a Jbn or Ka a Kbd, independently of each other, can be replaced by 1-4 substituents, Petition 870260073221, dated 07 / 23 / 2026, p. 38 / 259 33 / 240 independently selected from fluorine, chlorine, cyano and methyl); or F. Ja or Jbj, whose Ja or Jbj ring may independently be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-alkyl- C3)N(H)C(O), NH2C(O)-alkoxy-C1-C3 (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, benzyl, phenoxy, heteroaryl or heterocyclyl groups may independently be substituted by 1-4 substituents independently selected from halogen, cyano and C1-C3 alkyl); or G. Ja or Jbj, whose Ja or Jbj ring can independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, isopropyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenoxy, Ja to Jbn and Ka to Kbd (whose benzyl, phenoxy, J and K rings, independently of each other, can be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or H. Ja or Jbj, whose Ja or Jbj ring can independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, isopropyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, phenoxy, J and K rings ...SO2, (methyl)SO2, benzyl, phenyl, phenoxy, J and K rings, independently of each other, can be substituted by 1 to 4 substituents, independently selected from phenyl, phenoxy, J and K rings, independently of each other, Petition 870260073221, dated 07 / 23 / 2026, p. 39 / 259 34 / 240 replaced by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0064] In one embodiment of each aspect of the invention, J is A. C1-C4-C(O) alkyl, C3-C4-C(O) cycloalkyl, C(O) aryl, C5-C10-C(O) heteroaryl or C4-C10-C(O) heterocyclyl, wherein the alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, heteroaryl and heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rd; or B. C1-C3-C(O) alkyl, C3-C4-C(O) cycloalkyl, Ja-C(O) to Jdl-C(O) or Ka-C(O) to Kbd-C(O), whose alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and whose Ja to Jdl and Ka to Kbd groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rd; or C. alkyl-C1-C3-C(O), cycloalkyl-C3-C4-C(O), Ja-C(O) to Jdl-C(O) or Ka-C(O) to Kbd-C(O), whose alkyl group may be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano and methoxy, whose cycloalkyl group may be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose Ja to Jdl and Ka to Kbd groups may independently be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano and methoxy. Petition 870260073221, dated 07 / 23 / 2026, p. 40 / 259 35 / 240 substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-Ca alkyl, C1-C3 alkoxy, NHaC(O), (C1-Ca alkyl)N(H)C(O), NHaC(O)C1-Ca alkoxy, (C1-Ca alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups may independently be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-Ca alkyl); or D. alkyl-C1-Ca-C(O), cycloalkyl-Ca-C4-C(O), Ja-C(O) to Jdl-C(O) or Ka-C(O) to Kbd-C(O), whose alkyl may be substituted by 1a 3 substituents, independently selected from chlorine, fluorine, cyanine and methoxy, whose cycloalkyl may be substituted by 1a 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose Ja to Jdl and Ka to Kbd may, independently of each other, be substituted by 1a 4 substituents, independently selected from halogen, cyano, alkyl-C1-C3, alkoxy-C1-C3, NH2C(O), (alkyl-C1-C3)N(H)C(O), NH2C(O)alkoxy-C1-C3, (alkyl-C1-C3)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by i-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0065] In one embodiment of each aspect of the invention, J is A. alkyl-C1-C4-S(O)2, cycloalkyl-C1-C4-S(O)2, aryl-S(O)2, heteroaryl-C5-C10-S(O)2 or heterocyclyl-C4-C10S(O)2, wherein the alkyl may be substituted by ia 3 Petition 870260073221, dated 07 / 23 / 2026, p. 41 / 259 36 / 240 substituents, independently selected from Ra, whose cycloalkyl group can be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, heteroaryl and heterocyclyl groups can, independently of each other, be substituted by 1 to 4 substituents, independently selected from Re; or B. C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, Ja-S(O)2 to Jdl-S(O)2 or Ka-S(O)2 to Kbd-S(O)2, wherein the alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl groups, Ja to Jdl and Ka to Kbd, may independently be substituted by 1 to 4 substituents, independently selected from Re; or C. alkyl-C1-C3-S(O)2, cycloalkyl-C3-C4-S(O)2, Ja-S(O)2 to Jdl-S(O)2 or Ka-S(O)2 to Kbd-S(O)2, whose alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine and methoxy, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose Ja to Jdl and Ka to Kbd may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, alkyl-C1-C3, alkoxy-C1-C3, NH2C(O), (alkyl-C1-C3)N(H)C(O), NH2C(O)alkoxy-C1-C3, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl, Petition 870260073221, dated 07 / 23 / 2026, p. 42 / 259 37 / 240 independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl; or D. C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, Ja-S(O)2 to Jdl-S(O)2 or Ka-S(O)2 to Kbd-S(O)2, whose alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose Ja to Jdl and Ka to Kbd may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or E. C1-C4 alkoxy, C3-C4-C1-C2 cycloalkyl, aryloxy, C1-C2 aryl-alkoxy, C5-C10-C1-C2 heteroaryl or C4-C10-C1-C2 heterocyclyl, wherein the alkoxy may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, heteroaryl and heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rf; or Petition 870260073221, dated 07 / 23 / 2026, p. 43 / 259 38 / 240 F. alkoxy-C1-C3, cycloalkyl-C3-C4methoxy, cycloalkyl-C3C4ethoxy, aryloxy, Ja-methoxy to Jdl-methoxy, Ja-ethoxy to Jdl-ethoxy, Ka-methoxy to Kbd-methoxy or Ka-ethoxy to Kbdetoxy, whose alkoxy can be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl can be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, Ja to Jdl and Ka to Kbd can, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rf; or G. C1-C3 alkoxy, C3-C4 cycloalkylmethoxy, aryloxy, arylmethoxy, J1-ethoxy to Jdl-ethoxy or K1-ethoxy to Kbd-ethoxy, wherein the alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and wherein the aryl, J1 to Jdl and K1 to Kbd may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NHaC(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups may independently be substituted by i-4 substituents independently selected from halogen, cyano and C1-C3 alkyl); or Petition 870260073221, dated 07 / 23 / 2026, p. 44 / 259 39 / 240 H. C1-C3 alkoxy, C3-cycloalkyl-C4methoxy, phenyl-methoxy, Ja-ethoxy to Jdl-ethoxy or Ka-ethoxy to Kbd-ethoxy, whose alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose aryl groups, Ja to Jdl and Ka to Kbd, may independently be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or I. methoxy, ethoxy, isopropoxy, propoxy, cyclopropylmethoxy, phenylmethoxy (or benzyloxy), Ja-ethoxy to Jdl-ethoxy or Ka-ethoxy to Kbd-ethoxy, whose cyclopropyl group may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine and methoxy, and whose aryl groups, Ja to Jdl and Ka to Kbd, may independently be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-alkyl- C3)N(H)C(O), NH2C(O)-alkoxy-C1-C3, (alkyl-C1-C3)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl Petition 870260073221, dated 07 / 23 / 2026, p. 45 / 259 40 / 240 or heterocyclyl groups, independently of each other, can be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl groups.

[0066] In one embodiment of each aspect of the invention, J is A. hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl-C1-C2 alkyl, wherein the alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected, of chlorine, fluorine, cyano, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected, of halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl,phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or, B. hydrogen, methyl, ethyl, methoxy, ethoxy, aryl-methoxy, methyl-S(O)2, ethyl-S(O)2, cyclopropyl-S(O)2, Petition 870260073221, dated 07 / 23 / 2026, p. 46 / 259 41 / 240 cycloalkyl-C3-C4-methyl, heteroaryl-C5-C10, heterocyclyl-C4-C10, aryl-alkyl-C1-C2, aryl or heteroaryl-C5-C10-alkyl-C1-C2, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and wherein the aryl, heteroaryl and heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, alkyl-C1-C3, alkoxy-C1-C3, NH2C(O), (alkyl-C1-C3)N(H)C(O), NH2C(O)alkoxy-C1-C3, (alkyl-C1-C3)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by i-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or C. hydrogen, methyl, ethoxy, phenyl, benzyl, phenylmethoxy, methyl-S(O)2, cyclopropyl-S(O)2, cyclopropylmethyl, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc or Kbd, Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose phenyl, benzyl, J rings and K rings can independently be substituted by 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings, independently of each other, can be substituted) Petition 870260073221, dated 07 / 23 / 2026, p. 47 / 259 42 / 240 by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl). Petition 870260073221, dated 07 / 23 / 2026, p. 48 / 259 43 / 240 Scheme 1: Examples of monocyclic aryl & heteroaryl substituents (Ja to Jbn) - where, regardless of J, Rx is Rb, Rd, Re, Rf or Rg, en is 0 to 4 (where n is limited based on the potential available connection points) Already JdJe Jaj Jack Jal Jam Jan Jf JK Jc Ji Jj Jo Jap Jaq Jp Jq Jr Jn NODE Js Jt O—N Ju N—S Jv S—N Jx Jy N—N Jz Jw Jaa Jab Jad Jae Jaf Jag Jah Jai Jbi Jbj Jbm Jbn Petition 870260073221, dated 07 / 23 / 2026, p. 49 / 259 44 / 240 Scheme 2: Examples of aryl, heteroaryl, and bicyclic heterocyclic substituents (Jb0 to Jd1) - where, regardless of J, Rx is Rb, Rd, Rf, or Rg, and n is 0 to 4 (where n is limited based on the potential available connection points) - the connection to the rest of the compound can be any ring. (R)r Jbo JBP (R)r Jbq (R ). Jbr (R ). (RX), (RX), (RX)r Jbv Jbs (R )r Jbw Jbt Jbx (RX), Jbu Jby (RX)r Jbz (RX)r (RX). Jcd Jca Jce (RX)r(R ). JCB (R ). Jcc (R )r Jcg (RX), (R ). (R )r Jch (R )r Jci Jcf Jcj Jack (RX), Jcl JCP Jcq Jcy Jdk Jdl Petition 870260073221, dated 07 / 23 / 2026, p. 50 / 259 45 / 240 Scheme 3: Examples of heterocyclic substituents (Ka to Kbd) - where, independently of J, Rx is Rb, Rd, Re, Rf or Rg, and n is 0 to 4 (where n is limited based on the available potential connection points). KayKaz Kbc Kba q Kbb Kbd Petition 870260073221, dated 07 / 23 / 2026, p. 51 / 259 46 / 240

[0067] In one embodiment of each aspect of the invention, T is A. hydrogen, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C4 cycloalkyl, C1-C2 alkyl, C1-C2 aryl alkyl or C5-C10 heteroaryl, C1-C2 alkyl, whose alkyl, C3-C4 alkenyl and C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl groups may independently be substituted by 1 to 4 substituents, independently selected from Rg; or B. hydrogen, C1-C3 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C4 cycloalkyl-methyl, aryl-methyl, aryl-ethyl, C5-C10 heteroaryl-methyl or C5-C10 heteroaryl-ethyl, whose alkyl, C3-C4 alkenyl, C3-C4 alkynyl groups may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl groups may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl groups may independently be substituted by 1 to 4 substituents, independently selected from Rg; or C. hydrogen, methyl, ethyl, isopropyl, propyl, allyl, propargyl, cyclopropylmethyl, benzyl, Ja to Jdl-methyl or Ja to Jdl-ethyl, wherein the methyl, ethyl, isopropyl, propyl, allyl, propargyl groups may independently be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano Petition 870260073221, dated 07 / 23 / 2026, page 52 / 259 47 / 240 and methoxy, whose cyclopropyl group may be substituted by 1 to 3 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy, and whose benzyl and Jaa to Jdl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rg; or D. hydrogen, methyl, ethyl, isopropyl, propyl, allyl, propargyl, cyclopropylmethyl, benzyl, Jaa to Jdl-methyl or Jaa to Jdl-ethyl, whose methyl, ethyl, isopropyl, propyl, allyl, propargyl groups may independently be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano and methoxy groups, whose cyclopropyl groups may be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy groups, and whose benzyl and Jaa to Jdl groups may independently be substituted by 1 to 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy groups; or E. hydrogen, methyl, ethyl, isopropyl, propyl, allyl, propargyl, cyclopropylmethyl, benzyl, Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose methyl, ethyl, isopropyl, propyl, allyl, propargyl groups may independently be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano and methoxy, whose cyclopropyl group may be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy, and whose benzyl and J rings may independently be substituted by 1 to Petition 870260073221, dated 07 / 23 / 2026, page 53 / 259 48 / 240 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy.

[0068] In one embodiment of each aspect of the invention, Raé selected from A. halogen, cyano and C1-C3 alkoxy; or B. Chlorine, fluorine, cyano, and methoxy.

[0069] In one embodiment of each aspect of the invention, Rcé selected from A. halogen, cyano, C1-C3 alkyl and C1-C3 alkoxy; or B. Chlorine, fluorine, cyano, methyl, and methoxy.

[0070] In one embodiment of each aspect of the invention, Rb, Rd, Ree, and Rf are selected from A. halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C4-C10 heterocyclyl (whose phenyl, phenoxy, heteroaryl and heterocyclyl groups may independently be substituted by 1-4 substituents independently selected from halogen, cyano and C1-C3 alkyl); or B. halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups may independently be substituted by 1-4 substituents independently selected from halogen, cyano and C1-C3 alkyl); or C. halogen, cyano, C1-C3-alkyl, C1-C3-alkoxy, NH2C(O), (C1-C3-alkyl)N(H)C(O), NH2C(O)-C1-C3-alkoxy (C1-C3-alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and Petition 870260073221, dated 07 / 23 / 2026, page 54 / 259 49 / 240 heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups may independently be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl groups); or D. Fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl); or E. fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0071] In one embodiment of each aspect of the invention, Rgé selected from A. halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C4-C10 heterocyclyl (whose phenyl, phenoxy, heteroaryl and heterocyclyl groups may independently be substituted by 1-4 substituents independently selected from halogen, cyano and C1-C3 alkyl); or B. halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, benzyl, phenyl and phenoxy; or C. Fluorine, chlorine, cyano, methyl, ethyl, and methoxy. Petition 870260073221, dated 07 / 23 / 2026, p. 55 / 259 50 / 240

[0072] The present invention accordingly makes available a compound of formula I in which X, R1, R2, R3, R4, R5, R6, R7, Y and J are as defined above in all combinations / each permutation. Accordingly, a compound of formula I is made available, for example, of the first aspect, with X being embodiment A (i.e., O, S, SO, SO2, CH2 or SO(NH) ); R1 being the E embodiment (i.e., R1 is hydrogen, chlorine, fluorine, methyl, trifluoromethyl or difluoromethyl); R2 being an F embodiment (i.e., R2 is hydrogen); R3 being an F embodiment (i.e., R3 is hydrogen); R4 being an F embodiment (i.e., R4 is hydrogen); R5 being the E embodiment (i.e., R5 is hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl or difluoromethyl); R6 being an F embodiment (i.e., R6 is hydrogen); R7 being an F embodiment (i.e., R7 is hydrogen); Y being the C embodiment (i.e., it is hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl or methoxymethyl); and J being of the first aspect, wherein Ra is the B embodiment (i.e., selected from chlorine, fluorine, cyano and methoxy);Rbé is embodiment E (i.e., selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl and K rings, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl)); Rcé is embodiment B (i.e., selected from chlorine, fluorine, cyano, methyl and methoxy); and Rd, Ree Rf are each an embodiment A (i.e., selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C4-C10 heterocyclyl (whose phenyl,; Petition 870260073221, dated 07 / 23 / 2026, page 56 / 259 51 / 240 phenoxy, heteroaryl and heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl groups.

[0073] The present invention accordingly makes available a compound of formula I in which X, R1, R2, R3, R4, R5, R6, R7 and T are as defined above in all combinations / each permutation. Accordingly, a compound of formula I is made available, for example, with X being the embodiment D (i.e., O); R1 being the embodiment E (i.e., R1 is hydrogen, chlorine, fluorine, methyl, trifluoromethyl or difluoromethyl); R2 being an embodiment F (i.e., R2 is hydrogen); R3 being an embodiment F (i.e., R3 is hydrogen); R4 being an embodiment F (i.e., R4 is hydrogen); R5 being the embodiment E (i.e., R5 is hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl or difluoromethyl); R6 being an embodiment F (i.e., R6 is hydrogen); R7 being an embodiment F (i.e., R7 is hydrogen);and T being the C embodiment (i.e., hydrogen, methyl, ethyl, isopropyl, propyl, allyl, propargyl, cyclopropylmethyl, benzyl, Ja to Jdl-methyl or Ja to Jfethyl, wherein the methyl, ethyl, isopropyl, propyl, allyl, propargyl groups may independently be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano and methoxy groups, wherein the cyclopropyl groups may be substituted by 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy groups, and wherein the benzyl and Ja to Jdl groups may independently be substituted by 1 to 4 substituents independently selected from Rg; wherein; Petition 870260073221, dated 07 / 23 / 2026, page 57 / 259 52 / 240 Rg is the C modality (that is, Rg is selected from fluorine, chlorine, cyano, methyl, ethyl, and methoxy).

[0074] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I has X as O or CH2; R1, R2, R3 and R4 as independently selected from hydrogen, chlorine, fluorine, methyl, trifluoromethyl and difluoromethyl; R5, R6 and R7 as independently selected from hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl and difluoromethyl; Y as hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl or methoxymethyl; and J as hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl-C1-C2 alkyl, wherein the C1-C3 alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy,whose cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1, Petition 870260073221, dated 07 / 23 / 2026, pp. 58 / 259 53 / 240 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0075] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I has X as O or CH2; R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl or methoxymethyl; and J as hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl-C1-C2 alkyl, wherein the C1-C3 alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy compounds, and whose aryl, heteroaryl and heterocyclyl groups may,independently of each other, being substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0076] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I has X as O or CH2; R1, R2, R3 and R4 each as hydrogen; R5, Petition 870260073221, dated 07 / 23 / 2026, p. 59 / 259 54 / 240 R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl-C1-C2 alkyl, wherein the C1-C3 alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may independently be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl,phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl groups).

[0077] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I has X as O or CH2; R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, methyl, ethoxy, benzyloxy, cyclopropyl-S(O)2, cyclopropylmethyl, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc, Kbd, phenyl, benzyl, Jaa-methyl, Jaf-ethyl or Jaw-methyl, wherein phenyl, benzyl, Petition 870260073221, dated 07 / 23 / 2026, p. 60 / 259 55 / 240 benzyloxy, J rings and K rings may independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings, independently of each other, may be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0078] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I is represented by formula Ia (when X is CH2) or formula Iaa (when X is O) and, in each case, has R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen;and J as hydrogen, methyl, ethoxy, benzyloxy, cyclopropyl-S(O)2, cyclopropylmethyl, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc, Kbd, phenyl, benzyl, Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose phenyl, benzyl, benzyloxy, J rings and K rings may independently be substituted by 1 to 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings, independently of each other, may be substituted by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0079] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I is represented by formula Ia (when X is CH2) or formula Iaa (when X is O) and, in each case, has R1, R2, R3 and R4 each Petition 870260073221, dated 07 / 23 / 2026, page 61 / 259 56 / 240 as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, Ja or Jbj, whose J rings may independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings may independently be substituted by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0080] In one embodiment of each aspect of the invention (excluding the second aspect), the compound of formula I is represented by formula Ia (when X is CH2) or formula Iaa (when X is O) and, in each case, has R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, Ja or Jbj, whose J rings can, independently of each other, be substituted by 1 to 4 substituents, independently selected from methyl, NH2C(O), (methyl)N(H)C(O) and phenyl.

[0081] In one embodiment of the second aspect of the invention, the compound of formula I has X as O; R1, R2, R3 and R4 as independently selected from hydrogen, chlorine, fluorine, methyl, trifluoromethyl and difluoromethyl; R5, R6 and R7 as independently selected from hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl and difluoromethyl; Y as hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl or methoxymethyl; and J as hydrogen, C1-C3-alkyl, C1C3-alkoxy, aryl-C1-C2-alkoxy, C1-alkyl-C3-S(O)2, cycloalkyl-C3C4-S(O)2, cycloalkyl-C3-C4-C1-C2-alkyl, heteroaryl-C5C10, heterocyclyl-C4-C10, aryl-C1-C2-alkyl, aryl or heteroaryl-C5-C10-C1-C2-alkyl, which C1-C3-alkyl can Petition 870260073221, dated 07 / 23 / 2026, page 62 / 259 57 / 240 may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine and methoxy, whose C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine, methyl and methoxy, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyanine, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5-C6 and heterocyclyl-C5-C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0082] In one embodiment of the second aspect of the invention, the compound of formula I has X as O or CH2; R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl or methoxymethyl; and J as hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl-C1-C2 alkyl, wherein the C1-C3 alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted Petition 870260073221, dated 07 / 23 / 2026, page 63 / 259 58 / 240 by 1 to 3 substituents, independently selected from chlorine, fluorine, cyanine, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from halogen, cyanine, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 14 substituents, independently selected from fluorine, chlorine, cyanine and methyl).

[0083] In one embodiment of the second aspect of the invention, the compound of formula I has X as O; R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen;and J as hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4S(O)2 cycloalkyl, C3-C4 cycloalkyl-methyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl C1-C2 alkyl, wherein the C1-C3 alkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano and methoxy, wherein the C1-C3 alkoxy may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from chlorine, fluorine, cyano, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may independently be substituted by 1 to 4 substituents, independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O); Petition 870260073221, dated 07 / 23 / 2026, page 64 / 259 59 / 240 NH2C(O)-alkoxy-C1-C3, (alkyl-C1-C3)SO2, benzyl, phenyl, phenoxy, heteroaryl-C5—C6 and heterocyclyl-C5—C6 (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0084] In one embodiment of the second aspect of the invention, the compound of formula II has X as O; R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, methyl, ethoxy, benzyloxy, cyclopropyl-S(O)2, cyclopropylmethyl, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc, Kbd, phenyl, benzyl, Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose phenyl, benzyl, benzyloxy, J rings and K rings may independently be substituted by 1 to 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)-methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings, independently of each other, can be replaced by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0085] In one embodiment of the second aspect of the invention, the compound of formula II is represented by formula Iaa and has R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, methyl, ethoxy, benzyloxy, cyclopropyl-S(O)2, cyclopropylmethyl, Jh, Jz, Jaa, Jag, Jas, Jat, Jaw, Jax, Jay, Jaz, Jba, Jbc, Jbd, Jbe, Jbj, Jbk, Jbl, Jbm, Jcj, Jck, Jcl, Jcy, Jdk, Jdl, Kaz, Kbb, Kbc, Kbd, phenyl, benzyl, Petition 870260073221, dated 07 / 23 / 2026, p. 65 / 259 60 / 240 Jaa-methyl, Jaf-ethyl or Jaw-methyl, whose phenyl, benzyl, benzyloxy, J rings and K rings may independently be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings may independently be substituted by 1-4 substituents, independently selected from fluorine, chlorine, cyano and methyl).

[0086] In one embodiment of the second aspect of the invention, the compound of formula II is represented by formula Iaa and has R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, Ja or Jbj, whose J rings may independently be substituted by 1 to 4 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, methoxy, NH2C(O), (methyl)N(H)C(O), NH2C(O)methoxy, (methyl)SO2, benzyl, phenyl, phenoxy, Kba, Jbm and Jbn (whose phenyl, J and K rings may independently be substituted by 1-4 substituents independently selected from fluorine, chlorine, cyano and methyl).

[0087] In one embodiment of the second aspect of the invention, the compound of formula II is represented by formula Iaa and has R1, R2, R3 and R4 each as hydrogen; R5, R6 and R7 each as hydrogen; Y as hydrogen; and J as hydrogen, Ja or Jbj, whose J rings can, independently of each other, be substituted by 1 to 4 substituents, independently selected from methyl, NH2C(O), (methyl)N(H)C(O) and phenyl.

[0088] In one embodiment of each aspect of the invention, the compound of formula II has X as O or CH2; R1, R2, R3 and R4 Petition 870260073221, dated 07 / 23 / 2026, p. 66 / 259 61 / 240 as independently selected from hydrogen, chlorine, fluorine, methyl, trifluoromethyl and difluoromethyl; R5, R6 and R7 as independently selected from hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl and difluoromethyl; and T as hydrogen, methyl, ethyl, isopropyl, propyl, cyclopropylmethyl, benzyl, Ja to Jdl-methyl or Ja to Jdl-methyl, wherein the methyl, ethyl, isopropyl, propyl, cyclopropylmethyl groups may be substituted by 1 to 3 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy groups, and wherein the benzyl and Ja to Jdl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy groups;with the condition that, when X is CH2 in formula II, T is not hydrogen, a C1-C4 alkyl, 2-fluoroethyl, 2-methyl-4-pyrimidinyl)methyl, (methylsulfonyl)phenyl]methyl, 2-2,6-di(tert-butyl)-4-methylphenyl, 1,4-dihydro-6-methyl-4-oxo-3-pyridazinyl)methyl, 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl or tetrahydro-4,4-dimethyl-2-oxo-3-furanyl; or, when X is O in formula II, T is not hydrogen or a C1-C2 alkyl.

[0089] In one embodiment of each aspect of the invention, the compound of formula II has X as O or CH2; R1, R2, R3 and R4 as independently selected from hydrogen, chlorine, fluorine, methyl, trifluoromethyl and difluoromethyl; R5, R6 and R7 as independently selected from hydrogen, chlorine, fluorine, cyano, methyl, trifluoromethyl and difluoromethyl; and T as hydrogen, methyl, ethyl, isopropyl, propyl, cyclopropylmethyl, benzyl, Jaa-methyl, Jaf-ethyl or Jaw-methyl, wherein the methyl, ethyl, isopropyl, propyl, cyclopropylmethyl groups may be substituted by 1 to 3 Petition 870260073221, dated 07 / 23 / 2026, p. 67 / 259 62 / 240 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy, and whose benzyl and J rings may, independently of each other, be substituted by 1 to 4 substituents, independently selected from fluorine, chlorine, cyano, methyl, ethyl and methoxy; with the condition that, when X is CH2 in formula II, T is not hydrogen, a C1-C4 alkyl, 2-fluoroethyl, 2-methyl-4-pyrimidinyl)methyl, (methylsulfonyl)phenyl]methyl, 2- 2,6-di(tert-butyl)-4-methylphenyl, 1,4-dihydro-6-methyl-4-oxo-3-pyridazinyl)methyl, 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl or tetrahydro-4,4-dimethyl-2-oxo-3-furanyl; or, when X is O in formula II, T is not hydrogen or a C1-C2 alkyl.

[0090] In a third aspect, the present invention makes available a composition comprising a compound of formula I or II as defined in the first aspect, one or more auxiliaries and diluents and, optionally, one or more other active ingredients. In one embodiment, the composition is a pesticide composition.

[0091] In a fourth aspect, the present invention makes available a method for protecting plant propagation material from attack by insects, mites, nematodes or mollusks, comprising treating the propagation material, or the location where the propagation material is planted, with an effective amount of a compound of formula I or II as defined in the first aspect or a composition as defined in the third aspect.

[0092] In a fifth aspect, the present invention makes available a plant propagation material, such as a seed, comprising, or treated with, or adhered to, a Petition 870260073221, dated 07 / 23 / 2026, p. 68 / 259 63 / 240 compound of formula I or II as defined in the first aspect or a composition as defined in the third aspect.

[0093] In one embodiment of each aspect of the invention, the compound of formula I is represented by the formula Ia or Ib (when X is CH2, S, SO, SO2 or SO(NH)); or by the formula Iaa or Icc (when X is O).

[0094] In one embodiment of each aspect of the invention, the compound of formula II is represented by formula IIa or IIb (when X is CH2, S, SO, SO2 or SO(NH)); or by formula IIaa or IIcc (when X is O).

[0095] In one embodiment of each aspect of the invention, the compound of formula I is represented by formula Ia (when X is CH2, S, SO, SO2 or SO(NH)); or by formula Iaa (when X is O).

[0096] In one embodiment of each aspect of the invention, the compound of formula II is represented by formula IIa (when X is CH2, S, SO, SO2 or SO(NH)); or by formula IIaa (when X is O).

[0097] The present invention provides in a further aspect a method of controlling parasites in or on an animal in need thereof comprising administering an effective amount of a compound defined in the first aspect. The present invention further provides a method of controlling ectoparasites in an animal in need thereof comprising administering an effective amount of a compound of formula I or II as defined in the first aspect. The present invention further provides a method for preventing and / or treating diseases transmitted by ectoparasites comprising administering an effective amount of a compound of formula Petition 870260073221, dated 07 / 23 / 2026, p. 69 / 259 64 / 240 I or formula II as defined in the first aspect to an animal in need thereof.

[0098] The compounds of formulas I and II can be prepared by those skilled in the art using known methods. More specifically, the compounds of formulas I and II, and intermediates for them, can be prepared as described below in the schemes and examples.

[0099] The process according to the invention for preparing the compounds of formula I or formula II is carried out by methods known to those skilled in the art.

[0100] Compounds of formula I can be prepared, for example, as shown in Scheme 1. Diagram 1: R' R' III IIa' I

[0101] reaction of a compound with the formula IIa' with a compound of the formula III gives a compound of formula I, where R1, R2, R3, R4, R5, R6, R7, J and Y are as defined above for a compound of formula I. Useful coupling reagents include, for example, dicyclohexylcarbodiimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC), and carbonyldiimidazole. Additional useful coupling reagents in this method include O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluranium hexafluorophosphate (HATU), 1-propanephosphonic anhydride (T3P), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluranium tetrafluoroborate (TATU), and Petition 870260073221, dated 07 / 23 / 2026, page 70 / 259 65 / 240 2-(1H-benzotriazol-1-yl)-1,1,3,3tetramethyluranium hexafluorophosphate (HBTU). These coupling reagents are generally used in the presence of a base such as triethylamine, pyridine, 4-(dimethylamino)pyridine or N,N-diisopropylethylamine. Typical reaction conditions include an anhydrous aprotic solvent such as ethyl acetate, dichloromethane, tetrahydrofuran or N,N-dimethylformamide, and a reaction temperature between room temperature and 80 °C. For reaction conditions useful in the Scheme 1 method, as well as other well-established coupling conditions, see, for example, Bioorg. Med. Chem. 2015, 23 (3), 564; J. Org. Chem. 2008, 73 (7), 2731; Tetrahedron Lett. 2009, 50 (45), 6200; and Org. Lett. 2011, 13 (12), 2988. The compounds of formula III are known or can be prepared by methods known to a person skilled in the art.

[0102] Additionally, compounds of formula I can be prepared, for example, as shown in scheme 2. Scheme 2: IV III I

[0103] The reaction of a compound of formula IV with a compound of formula III gives a compound of formula I, wherein R1, R2, R3, R4, R5, R6, R7, J and Y are as defined above for a compound of formula I. Typical reaction conditions include an organic solvent, such as ethyl acetate, dichloromethane, tetrahydrofuran or N,N-dimethylformamide, and a reaction temperature between room temperature and 80°C. Petition 870260073221, dated 07 / 23 / 2026, p. 71 / 259 66 / 240 The presence of an acid scavenger such as triethylamine, pyridine, 4-(dimethylamino)pyridine, or N,N-diisopropylethylamine. Other scavengers include hydroxides such as sodium hydroxide and potassium hydroxide, or carbonates such as sodium carbonate and potassium carbonate. The compounds of the formula III. are known or can be prepared by methods known to a person skilled in the art.

[0104] Compounds of formula IV can be prepared, for example, as shown in the scheme.

[0105] treatment Chlorinating agent A compound of formula lia, with a chlorinating reagent such as thionyl chloride, oxalyl chloride or phosphorus oxychloride in a solvent such as dichloromethane or toluene and optionally in the presence of a catalytic amount of N,N-dimethylformamide can provide the corresponding acid chloride of formula IV, where R1, R2, R3, R4, R5, R6 and R7 are as defined above for a compound of formula I.

[0106] Compounds of the formula lia' can be prepared, for example, as shown in Scheme 4. Scheme 4: Petition 870260073221, dated 07 / 23 / 2026, page 72 / 259 67 / 240

[0107] The basic or acid hydrolysis reaction of a compound of formula II gives a compound of formula 1a, where R1, R2, R3, R4, R5, R6 and R7 are as defined above for a compound of formula II and T is alkyl-C1-Ca (e.g., methyl or ethyl), preferably using a slight excess of a hydroxide base (e.g., lithium hydroxide, sodium hydroxide or potassium hydroxide) in a water-miscible solvent such as methanol, ethanol, tetrahydrofuran or 1,4-dioxane with or without water at a temperature between 0 and 80 °C. The product can be isolated by adjusting the pH to about 1 to 3 and then filtering or extracting, optionally after removing the organic solvent by evaporation.

[0108] Compounds of formula II can be prepared, for example, as shown in Scheme 5. And Scheme 5:

[0109] Treatment of a compound of formula V with a compound of formula VI gives compounds of formula II, wherein R1, R2, R3, R4, R5, R6, R7 and T are as defined above for a compound of formula II in the presence of a transition metal catalyst such as Rh2ÜAc4 (i.e., rhodium(II) acetate dimer), Rh2oct4 (i.e., rhodium(II) octanoate dimer), Rh2esp2 (i.e., bis[rhodium(α,α,α',« 'tetramethyl-1,3-benzenedipropionic acid)]) or copper sulfate. Petition 870260073221, dated 07 / 23 / 2026, page 73 / 259 68 / 240 The reaction can be carried out with or without a solvent. More typically, the reaction is conducted in a liquid phase with a solvent such as methylene chloride, hexanes or toluene, and a reaction temperature between -78 and 110 °C. General procedures for the cyclopropanation of diazoesters with olefins are well documented in the chemical literature, see for example WO 1998 / 057968. The compounds of formulas V and VI are known or can be prepared by methods known to a person skilled in the art. Scheme 6:

[0110] Compounds of formula V, where each of R1, R2, R3, R4, R5 and R6 is hydrogen, and X is S, can be prepared, for example, as shown in Scheme 6. Reactions of this type are typically carried out using AC2O in the presence of an acid catalyst such as p-toluenesulfonic acid or trifluoromethylacetic acid in a solvent such as methylene chloride, hexanes or toluene, and a reaction temperature between -78 and 110 °C. General procedures for the Pummerer reaction are well documented in the chemical literature; see, for example, The Pummerer Reaction of Sulfinyl Compounds https: / / doi.org / 10.1002 / 0471264180.or040.03. Compounds of formula VII are known or can be prepared by methods known to a person skilled in the art. Scheme 7: Petition 870260073221, dated 07 / 23 / 2026, p. 74 / 259 69 / 240

[0111] The reaction of a compound of formula VIII with a compound of formula IX gives a compound of formula I, where R1, R2, R3, R4, R5, R6, R7, J and Y are as defined above for a compound of formula I and LG is a labile group such as a halide (e.g., Cl, Br, I) or sulfonate (e.g., mesylate, triflate, p-toluenesulfonate) and the like. Reactions of this type are typically carried out using a palladium catalyst such as palladium(II) acetate with a phosphine ligand such as t-BuBrettPhos (i.e., 2-(di-tert-butylphosphino)2',4',6'-tri-isopropyl-3,6-dimethoxy-1,1'-biphenyl) or a copper catalyst such as copper(I) iodide with an N-diamine ligand such as trans-N,N'-dimethylcyclohexane-1,2-diamine. These reactions traditionally require the presence of a base, such as potassium carbonate or potassium phosphate, in an organic solvent such as tert-butanol, toluene, or dioxane, and a reaction temperature between 110 °C and 110 °C (see, for example, Tetrahedron 2009, 65, 6576). The compounds of formula IX are known or can be prepared by methods known to a person skilled in the art. Scheme 8: VIII I Petition 870260073221, dated 07 / 23 / 2026, p. 75 / 259 70 / 240

[0112] Alternatively, compounds of formula I can be prepared, for example, as shown in Scheme 8, where R1, R2, R3, R4, R5, R6, R7, J and Y are as defined above for a compound of formula I and Lg is a labile group such as a halide (e.g., Cl, Br, I) in the presence of a base such as sodium hydride or in the presence of a dilute acid such as hydrochloric acid. Reactions of this type are typically carried out in a solvent such as dimethyl sulfoxide, N,N-dimethylformamide or tert-butanol, at a temperature ranging from about room temperature to the reflux temperature of the reaction mixture. Scheme 9:

[0113] NH3 Ammonia can be substituted for the compound of formula III in the reactions of Schemes 1 and 2 to give compounds of formula Ia' where J and Y are H and R1, R5, R3, R4, R2, R6 and R7 are as defined above for a compound of formula I. An acid chloride of formula IV can also be generated in situ from a compound of formula II with thionyl chloride before the addition of ammonia, optionally in the presence of a base such as triethylamine or N,N-diisopropylethylamine. For reaction conditions useful in the Scheme 8 method, see, for example, J. Am. Chem. Soc. 2015, 137. 2042. Scheme 10: X III I III XI Petition 870260073221, dated 07 / 23 / 2026, p. 76 / 259 71 / 240

[0114] The compounds of formula I can be prepared by rhodium-catalyzed oxidative amidation of alcohols of formula X with amines of formula III, where R1, R2, R3, R4, R5, R6, R7, J and Y are as defined above for a compound of formula I. This reaction is typically carried out in the presence of a catalyst such as Rh(COD)2BF4 (i.e., bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate), a ligand such as 4,5-bis(diphenylphosphine)-9,9-dimethylxanthene (i.e., Xantfos) or 1,4-bis(diphenylphosphine)butane (i.e., DPPB), a hydrogen acceptor such as trifluoroacetophenone and a base such as cesium acetate or cesium carbonate. The reaction can be carried out in an aprotic solvent such as tetrahydrofuran or dioxane with temperatures ranging from 0 to 100 °C (see, for example, ACS catalysis 2016, 6, 8214).Alternatively, compounds of formula I can be prepared by coupling alcohols of formula X with amines of formula III in the presence of a catalyst such as RuHClCO(AsPh3)3 (i.e., carbonylchlorohydrotris(triphenylarsine)ruthenium(II)) with a suitable thiocarboxamide ligand such as 2-pyridinecarbothioamide. The reaction is typically carried out under aerobic conditions in an organic solvent such as ethanol at a temperature ranging from about room temperature to the solvent reflux temperature (see, for example, Organometallics 2014, 33, 4269). Additionally, compounds of formula I can also be prepared by rhodium-catalyzed oxidative amidation of aldehydes of formula XI with amines of formula III. Petition 870260073221, dated 07 / 23 / 2026, p. 77 / 259 72 / 240 Scheme 11:

[0115] Alcohols of formula X and aldehydes of formula XI can be prepared from esters of formula II, where R1, R2, R3, R4, R5, R6 and R7 are as defined above for a compound of formula I and where T is alkyl (e.g., methyl or ethyl), according to general methods known to a person skilled in the art. In one example, a suitable amount of reducing agent such as diisobutylaluminum hydride, in an aprotic solvent such as dichloromethane or tetrahydrofuran, at a suitable temperature, results in the transformation of a compound of formula V into compounds of formulas X and XI.

[0116] Schemes 1 to 11 illustrate methods for preparing compounds of formulas I and II having a variety of substituents. Compounds of formulas I and II having substituents other than those particularly noted for Schemes 1 to 11 can be prepared by general methods known in the art of synthetic organic chemistry, including methods analogous to those described for Schemes 1 to 11. Petition 870260073221, dated 07 / 23 / 2026, p. 78 / 259 73 / 240

[0117] It is recognized by a person skilled in the art that various functional groups can be converted into others to provide different compounds of formulas I and II. For example, compounds of formula I, or intermediates for their preparation, may contain aromatic nitro groups, which can be reduced to amino groups and then converted through reactions well known in the art (e.g., Sandmeyer reaction) to various halides. By similar known reactions, aromatic amines (anilines) can be converted via diazonium salts to phenols, which can then be alkylated to prepare compounds of formula I with alkoxy substituents. Similarly, aromatic halides such as bromides or iodides prepared via the Sandmeyer reaction can react with alcohols under copper-catalyzed conditions, such as the Ullmann reaction or known modifications thereof, to provide compounds of formula I containing alkoxy substituents.Additionally, some halogen groups, such as fluorine or chlorine, can be displaced with alcohols under basic conditions to provide compounds of formula I containing the corresponding alkoxy substituents. Compounds of formula I or precursors thereof containing a halide, preferably bromide or iodide, are particularly useful intermediates for transition metal-catalyzed cross-coupling reactions to prepare compounds of formula I. These types of reactions are well documented in the literature; see, for example, Tsuji in Transition Metal Reagents and Catalysts: Innovations in Organic Synthesis, John Wiley and Sons, Chichester, 2002; Tsuji in Palladium in Organic Synthesis, Springer, 2005; and Miyaura and Buchwald in... Petition 870260073221, dated 07 / 23 / 2026, page 79 / 259 74 / 240 Cross Coupling Reactions: A Practical Guide, 2002; and references cited therein.

[0118] It is recognized that some reagents and reaction conditions described above for preparing compounds of formula I or II may not be compatible with certain functionalities present in the intermediates. In these cases, the incorporation of protecting / deprotecting sequences or interconversions of functional groups in the synthesis will assist in obtaining the desired products. The use and choice of protecting groups will be evident to an expert in chemical synthesis (see, for example, Greene, TW; Wuts, PGM Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). An expert in the art will recognize that, in some cases, after the introduction of the reagents illustrated in the individual schemes, additional routine synthetic steps not described in detail may be necessary to complete the synthesis of compounds of formula I or II.An expert in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the diagrams above in a different order than that implied by the particular sequence presented in order to prepare the compounds of formula I or II.

[0119] A person skilled in the art will also recognize that compounds of formula I or II and intermediates described herein may undergo various electrophilic, nucleophilic, radical, organometallic, oxidation and reduction reactions to add substituents or modify existing substituents.

[0120] Without further elaboration, it is believed that a person skilled in the art using the preceding description can utilize the present invention to its full extent. Petition 870260073221, dated 07 / 23 / 2026, p. 80 / 259 75 / 240

[0121] Depending on the procedure or reaction conditions, the reagents may be reacted in the presence of a base. Examples of suitable bases are alkali metal or alkaline earth metal hydroxides, alkali metal or alkaline earth metal hydrides, alkali metal or alkaline earth metal amides, alkali metal or alkaline earth metal alkoxides, alkali metal or alkaline earth metal acetates, alkali metal or alkaline earth metal carbonates, alkali metal or alkaline earth metal dialkylamides or alkali metal or alkaline earth metal alkylsilylamides, alkylamines, alkylenediamines, free or N-alkylated saturated or unsaturated cycloalkylamines, basic heterocycles, ammonium hydroxides, and carbocyclic amines.Examples that can be mentioned are sodium hydroxide, sodium hydride, sodium amide, sodium methoxide, sodium acetate, sodium carbonate, potassium tert-butoxide, potassium hydroxide, potassium carbonate, potassium hydride, lithium diisopropylamide, potassium bis(trimethylsilyl)amide, calcium hydride, triethylamine, diisopropylethylamine, triethylenediamine, cyclohexylamine, N-cyclohexyl-N,N-dimethylamine, N,N-diethylaniline, pyridine, 4-(N,N-dimethylamino)pyridine, quinuclidine, N-methylmorpholine, benzyltrimethylammonium hydroxide and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).

[0122] The reagents can be reacted with each other as is, i.e., without adding a solvent or diluent. In most cases, however, it is advantageous to add an inert solvent or diluent or a mixture thereof. If the reaction is carried out in the presence of a base, the bases that are employed Petition 870260073221, dated 07 / 23 / 2026, p. 81 / 259 76 / 240 in excess, such as triethylamine, pyridine, N-methylmorpholine or N,N-diethylaniline, may also act as solvents or diluents.

[0123] The reactions are advantageously carried out in a temperature range of approximately -80 °C to approximately +140 °C, preferably from approximately -30 °C to approximately +100 °C, in many cases in the range between room temperature and approximately +80 °C.

[0124] Depending on the choice of reaction conditions and starting materials that are suitable in each case, it is possible, for example, in one reaction step to replace only one substituent with another substituent according to the invention, or a plurality of substituents can be replaced by other substituents according to the invention in the same reaction step.

[0125] The salts of compounds of formulas I and II can be prepared in a manner known per se. Thus, for example, the acid addition salts of compounds of formulas I and II are obtained by treatment with a suitable acid or with a suitable ion exchange reagent, and the base salts are obtained by treatment with a suitable base or with a suitable ion exchange reagent.

[0126] The salts of compounds of formulas I and II can be converted in the usual manner into the free compounds I and II, respectively, the acid addition salts, for example, by treatment with a suitable basic compound or with a suitable ion exchange reagent, and the base salts, for example, by treatment with a suitable acid or with a suitable ion exchange reagent. Petition 870260073221, dated 07 / 23 / 2026, page 82 / 259 77 / 240

[0127] The salts of compounds of formulas I and II can be converted in a manner known per se into other salts of compounds of formulas I and II, respectively, and acid addition salts, for example, into other acid addition salts, for example by treating an inorganic acid salt such as hydrochloride with a suitable metal salt such as a sodium, barium or silver salt of an acid, for example with silver acetate, in a suitable solvent in which an inorganic salt that forms, for example silver chloride, is insoluble and thus precipitates from the reaction mixture.

[0128] Depending on the procedure or reaction conditions, the compounds of formulas I and II, which have salt-forming properties, can be obtained in free form or in salt form.

[0129] The compounds of formulas I and II and, where appropriate, the tautomers thereof, in each case in free form or in salt form, may be present in the form of one of the isomers that are possible or as a mixture thereof, for example in the form of pure isomers, such as antipodes and / or diastereomers, or as mixtures of isomers, such as mixtures of enantiomers, for example racemates, mixtures of diastereomers or mixtures of racemates, depending on the number, absolute and relative configuration of the asymmetric carbon atoms occurring in the molecule and / or depending on the configuration of the non-aromatic double bonds occurring in the molecule; the invention relates to pure isomers and also to all mixtures of isomers that are possible and should be understood, in each case, in this sense before or after, even when the details Petition 870260073221, dated 07 / 23 / 2026, page 83 / 259 78 / 240 stereochemicals are not specifically mentioned in each case.

[0130] Mixtures of diastereomers or mixtures of racemates of compounds of formula I or II, in free form or in salt form, which can be obtained depending on which starting materials and procedures have been chosen, can be separated, in a known manner, into pure diastereomers or racemates, based on the physicochemical differences of the components, for example by fractional crystallization, distillation and / or chromatography.

[0131] Mixtures of enantiomers, such as racemates, which can be obtained in a similar manner, can be resolved at the optical antipodes by known methods, for example by recrystallization from an optically active solvent, by chromatography on chiral adsorbents, for example by high-performance liquid chromatography (HPLC) on acetyl cellulose, with the aid of suitable microorganisms, by cleavage with specific immobilized enzymes, by forming inclusion compounds, for example using chiral crown ethers, where only one enantiomer is complexed, or by conversion into diastereomeric salts, for example by reacting a basic end-product racemate with an optically active acid, such as a carboxylic acid, for example camphoric, tartaric or malic acid, or a sulfonic acid, for example camphorsulfonic acid, and separating the mixture of diastereomers that can be obtained in this way,For example, by fractional crystallization based on their different solubilities, to give the diastereomers from which the desired enantiomer can be released by the action of suitable agents, for example, basic agents. Petition 870260073221, dated 07 / 23 / 2026, page 84 / 259 79 / 240

[0132] Pure diastereomers or enantiomers can be obtained, according to the invention, not only by separating mixtures of suitable isomers, but also by generally known methods of diastereoselective or enantioselective synthesis, for example by carrying out the process, according to the invention, with starting materials of suitable stereochemistry.

[0133] N-oxides can be prepared by reacting a compound of formula I or II with a suitable oxidizing agent, for example the H2O2 / urea adduct in the presence of an acid anhydride, e.g., trifluoroacetic anhydride. Such oxidations are known from the literature, for example from J. Med. Chem., 32 (12), 2561-73, 1989 or WO 2000 / 15615.

[0134] It is advantageous to isolate or synthesize in each case the most biologically effective isomer, for example enantiomer or diastereomer, or a mixture of isomers, for example a mixture of enantiomers or a mixture of diastereomers, if the individual components have different biological activity.

[0135] The compounds of formulas I and II and, where appropriate, the tautomers thereof, in each case in free form or in salt form, may, if appropriate, also be obtained in the form of hydrates and / or include other solvents, for example those that may have been used for the crystallization of compounds that are present in solid form.

[0136] Compounds of formula I according to the following Lists A-1 to A-36 can be prepared according to the methods described above. The following examples are intended to illustrate the invention and show preferred compounds of formula (I), in the form of a compound of formula IA. Petition 870260073221, dated 07 / 23 / 2026, p. 85 / 259 80 / 240 J AI

[0137] Each of Lists A-1 to A-36 comprises 57 compounds of formula (IA) where J is represented in Table 1, and X and Y are given in the relevant Lists A-1 to A-36.

[0138] List A-1 provides 57 compounds A-1.001 to A1.057 of formula IA where X is O, Y is H, and J is defined in Table 1. For example, A-1.001 is A-1.001

[0139] List A-2 provides 57 compounds A-2.001 to A2.057 of formula IA wherein X is O, Y is CH3, and J is defined in Table 1.

[0140] List A-3 provides 57 compounds A-3.001 to A3.057 of formula IA wherein X is O, Y is CH2-CH3, and J is defined in Table 1.

[0141] List A-4 provides 57 compounds A-4.001 to A4.057 of formula IA wherein X is O, Y is CH2-phenyl, and J is defined in Table 1.

[0142] List A-5 provides 57 compounds A-5.001 to A5.057 of formula IA wherein X is O, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0143] List A-6 provides 57 compounds A-6.001 to A6.057 of formula IA wherein X is O, Y is CH2-O-CH3, and J is defined in Table 1. Petition 870260073221, dated 07 / 23 / 2026, page 86 / 259 81 / 240

[0144] List A-7 provides 57 compounds A-7.001 to A7.057 of formula IA wherein X is CH2, Y is H, and J is defined in Table 1.

[0145] List A-8 provides 57 compounds A-8.001 to A8.057 of formula IA wherein X is CH2, Y is CH3, and J is defined in Table 1.

[0146] List A-9 provides 57 compounds A-9.001 to A9.057 of formula IA wherein X is CH2, Y is CH2-CH3, and J is defined in Table 1.

[0147] List A-10 provides 57 compounds A-10.001 to A10.057 of formula IA wherein X is CH2, Y is CH2-phenyl, and J is defined in Table 1.

[0148] List A-11 provides 57 compounds A-11.001 to A11.057 of formula IA wherein X is CH2, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0149] List A-12 provides 57 compounds A-12.001 to A12.057 of formula IA wherein X is CH2, Y is CH2-O-CH3, and J is defined in Table 1.

[0150] List A-13 provides 57 compounds A-13.001 to A13.057 of formula IA where X is S, Y is H, and J is defined in Table 1.

[0151] List A-14 provides 57 compounds A-14.001 to A14.057 of formula IA wherein X is S, Y is CH3, and J is defined in Table 1.

[0152] List A-15 provides 57 compounds A-15.001 to A15.057 of formula IA wherein X is S, Y is CH2-CH3, and J is defined in Table 1.

[0153] List A-16 provides 57 compounds A-16.001 to A16.057 of formula IA wherein X is S, Y is CH2-phenyl, and J is defined in Table 1. Petition 870260073221, dated 07 / 23 / 2026, page 87 / 259 82 / 240

[0154] List A-17 provides 57 compounds A-17.001 to A17.057 of formula IA wherein X is S, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0155] List A-18 provides 57 compounds A-18.001 to A18.057 of formula IA wherein X is S, Y is CH2-O-CH3, and J is defined in Table 1.

[0156] List A-19 provides 57 compounds A-19.001 to A19.057 of formula IA where X is SO, Y is H, and J is defined in Table 1.

[0157] List A-20 provides 57 compounds A-20.001 to A20.057 of formula IA wherein X is SO, Y is CH3, and J is defined in Table 1.

[0158] List A-21 provides 57 compounds A-21.001 to A21.057 of formula IA wherein X is SO, Y is CH2-CH3, and J is defined in Table 1.

[0159] List A-22 provides 57 compounds A-22.001 to A22.057 of formula IA wherein X is SO, Y is CH2-phenyl, and J is defined in Table 1.

[0160] List A-23 provides 57 compounds A-23.001 to A23.057 of formula IA wherein X is SO, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0161] List A-24 provides 57 compounds A-24.001 to A24.057 of formula IA wherein X is SO, Y is CH2-O-CH3, and J is defined in Table 1.

[0162] List A-25 provides 57 compounds A-25.001 to A25.057 of formula IA wherein X is SO2, Y is H, and J is defined in Table 1.

[0163] List A-26 provides 57 compounds A-26.001 to A26.057 of formula IA wherein X is SO2, Y is CH3, and J is defined in Table 1. Petition 870260073221, dated 07 / 23 / 2026, page 88 / 259 83 / 240

[0164] List A-2 7 provides 57 compounds A-27.001 to A27.057 of formula IA wherein X is SO2, Y is CH2-CH3, and J is defined in Table 1.

[0165] List A-28 provides 57 compounds A-28.001 to A28.057 of formula IA wherein X is SO2, Y is CH2-phenyl, and J is defined in Table 1.

[0166] List A-2 9 provides 57 compounds A-29.001 to A29.057 of formula IA wherein X is SO2, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0167] List A-30 provides 57 compounds A-30.001 to A30.057 of formula IA wherein X is SO2, Y is CH2-O-CH3, and J is defined in Table 1.

[0168] List A-31 provides 57 compounds A-31.001 to A31.057 of formula IA where X is SONH, Y is H, and J is defined in Table 1.

[0169] List A-32 provides 57 compounds A-32.001 to A32.057 of formula IA wherein X is SONH, Y is CH3, and J is defined in Table 1.

[0170] List A-33 provides 57 compounds A-33.001 to A33.057 of formula IA wherein X is SONH, Y is CH2-CH3, and J is defined in Table 1.

[0171] List A-34 provides 57 compounds A-34.001 to A34.057 of formula IA wherein X is SONH, Y is CH2-phenyl, and J is defined in Table 1.

[0172] List A-35 provides 57 compounds A-35.001 to A35.057 of formula IA wherein X is SONH, Y is CH2-cyclopropyl, and J is defined in Table 1.

[0173] List A-36 provides 57 compounds A-36.001 to A36.057 of formula IA wherein X is SONH, Y is CH2-O-CH3, and J is defined in Table 1. Table 1: Definitions of J substituents: Petition 870260073221, dated 23 / 07 / 2026, p. 89 / 259 84 / 240 J IUPAC Name J1 Cyclopropylsulfonyl J2 Cyclopropylmethyl J3 (1-methylsulfonylazetidine-3-yl) J4 Benzene J5 o -tolyl J6 m -tolyl J7 p -tolyl J8 (2-fluoro-4-methyl-phenyl) J19 (2-cyanopyrilyl Jdi22- 1320) J3 4-pyridyl J13 (1-methyl-2-oxo-3-pyridyl) J14 (2-methoxy-3-pyridyl) J15 (2-oxo-1-phenyl-3-pyridyl) J16 pyrimidine-4-yl J17 pyridazine-4-yl J18 pyridazine-pyridine-3-pyridyl (2-methyl-3-oxo-pyridazine-4-yl) J21 (3 methoxypyridazine-4-yl) J22 (1-methylpyrazol-3-yl) J2 3 (2-me tilpyrazol-3-yl) J2 4 (1-methylpyrazol-4-mel) J4-ltria (2-methylpyrazol-4-ltria) (1-methyl-1,2,4-triazol-3-yl) J2 7 pyrazole[1,5-a]pyridin-2-yl J2 8 [1,2,4]triazole[1,5-a]pyridin-2-yl J2 9 [1,2,4]triazol[1,5-a-2-yl-pyrazine-yl Petition 870260073221, dated 23 / 07 / 2026, p. 90 / 259 85 / 240 J30 (3,6-dichloropyrazine-2-yl) J31 [2-(5,5-dimethyl-2H-1,2,4-oxadiazol-3-yl)phenyl] J32 (8-chloro-6-methyl-[1,2,4].triazolo[1,5- a]pyridine-2-yl) J31. 2-(4H-1,2,4-triazol-3-yl)ethyl J34 [8-(2-amino-2-oxo-ethoxy)-6-quinolyl] J35 (1-methylpyrazolo[3,4-b]pyridine-3-yl)methyl J3 6 (2,5-dimethyl77-triazol)J34 (3-oxo-2-phenyl-isoxazolidine-4-yl) J38 (3-methyl-2-oxo-pyrimidine-4-yl) J39 1H-pyrazol-4-ylmethyl J4 0 (4-benzyl-1,5-di-hydrotetrazol-5-yl) J41-1,3-methyl-cyano-5-yl J42 [3-(6-oxo-1H-pyrimidine-2-yl)phenyl] J43 [2,5-dichloro-3-(methylcarbamoyl)phenyl] J44 (4-cyano-3-pyridyl) J45 [2-methoxy-5-(4-oxo-1H-pyridazine-]J4-yl) (5-chloro-4-methoxy-2-methyl-3-oxo-1, 6-di- hydropyridazine-6-yl) J47 (6-methyl-[1,2,4]triazolo[1,5-a]pyridine-2-yl) J4 8 (1-ethyltriazol-4-yl) J4 9 (4-methyl-7-oxo-8H-1,8-naphthyridine-2-yl) J50 (6-phenoxy-2-pyridyl)methyl J51 (5-cyano-6-oxo-1H-pyrimidine-2-yl) J52 Hydrogen J53 Methyl J54 methyl2-sulfonyl oxy (dimethylsulfonyl J-55 Petition 870260073221, dated 07 / 23 / 2026, p. 91 / 259 86 / 240 J57 Ethoxy

[0174] The compounds of formula II according to the following Lists B-1 to B-30 can be prepared according to the methods described above. The following examples are intended to illustrate the invention and show preferred compounds of the formula I, in the form of a compound with formula II-B. II-B

[0175] List B-1 provides a compound B-1.001 of formula II-B where X is O, and T is H. For example, B-1.001 is

[0176] List B-2 provides a compound B-2.001 of formula II-B where X is O, and T is CH3.

[0177] List B-3 provides a compound B-3.001 of formula II-B where X is O, and T is CH2-CH3.

[0178] List B-4 provides a compound B-4.001 of formula II-B where X is O, and T is CH2-phenyl.

[0179] List B-5 provides a compound B-5.001 of formula II-B where X is O, and T is CH2-cyclopropyl.

[0180] List B-6 provides a compound B-6.001 of formula II-B where X is CH2, and T is H.

[0181] List B-7 provides a compound B-7.001 of formula II-B where X is CH2, and T is CH3.

[0182] List B-8 provides a compound B-8.001 of formula II-B where X is CH2, and T is CH2-CH3. Petition 870260073221, dated 07 / 23 / 2026, p. 92 / 259 87 / 240

[0183] List B-9 provides a compound B-9.001 of formula

[0184] II-B in List B-10 where X is CH2, and T is CH2-phenyl.

[0185] List B-11 provides a compound B-11.001 of formula

[0186] II-B in List B-12 where X is S, and T is H.

[0187] II-B provides a compound B-12.001 of formula

[0188] II-B in List B-13 where X is S, and T is CH3.

[0189] II-B provides a compound B-13.001 of formula

[0188] II-B in List B-14 where X is S, and T is CH2-CH3. provides a compound B-14.001 of formula

[0189] II-B in A List where X B-15 is S, and T is CH2-phenyl. provides a compound B-15.001 of formula II-B where X is S, and T is CH2-cyclopropyl.

[0190] A List B-16 provides a compound B-16.001 of formula

[0191] II-B in A List where X B-17 is SO, and T is H. provides a compound B-17.001 of formula

[0192] II-B in A List where X B-18 is SO, and T is CH3. provides a compound B-18.

[0193] II-B in A List that X B-19 is SO, and T is CH2-CH3. provides a compound B-19.001 of formula

[0194] II-B in A List that X B-20 is SO, and T is CH2-phenyl. provides a compound B-20.001 of formula II-B in which X is SO, and T is CH2-cyclopropyl.

[0195] A List B-21 provides a compound B-21.001 of formula

[0196] II-B in A List that X B-22 is SO2, and T is H. provides a compound B-22.001 of formula

[0197] II-B in A List that X B-23 is SO2, and T is CH3. provides a compound B-23.001 of formula II-B in which X is SO2, and T is CH2-CH3. Petition 870260073221, dated 07 / 23 / 2026, page 93 / 259 88 / 240

[0198] List B-24 provides a compound B-24.001 of formula II-B where X is SO2, and T is CH2-phenyl.

[0199] List B-25 provides a compound B-25.001 of formula II-B where X is SO2, and T is CH2-cyclopropyl.

[0200] List B-26 provides a compound B-26.001 of formula II-B where X is SONH, and T is H.

[0201] List B-27 provides a compound B-27.001 of formula II-B where X is SONH, and T is CH3.

[0202] List B-28 provides a compound B-28.001 of formula II-B where X is SONH, and T is CH2-CH3.

[0203] List B-29 provides a compound B-29.001 of formula II-B where X is SONH, and T is CH2-phenyl.

[0204] List B-30 provides a compound B-30.001 of formula II-B where X is SONH, and T is CH2-cyclopropyl.

[0205] Certain compounds of formulas III and VI are innovative.

[0206] Accordingly, the present invention also makes available a compound of formula IIIa Y / J IIIa, • Y is H, and J is a substituent defined in Table 18; • Y is CH3, and J is a substituent defined in Table 18; • Y is CH2-CH3, and J is a substituent defined in Table 18; • Y is CH2-phenyl, and J is a substituent defined in Table 18; and • Y is CH2-O-CH3, and J is a substituent defined in Table 18.

[0207] The present invention additionally makes available a compound of formula VIa Petition 870260073221, dated 07 / 23 / 2026, p. 94 / 259 89 / 240 where T is

[0208] You Via, selected from the lists composed of the formula B-1 to B-5. Active ingredients I or II according to the invention are preventively and / or curatively valuable active ingredients in the area of ​​pest control, even at low application rates, which have a very favorable biocidal spectrum and are well tolerated by warm-blooded species, fish, and plants. The active ingredients according to the invention act against all developmental stages or individual developmental stages of normally sensitive, but also resistant, animal pests, such as insects or representatives of the order Acarina. The insecticidal or acaricidal activity of the active ingredients according to the invention can manifest itself directly, i.e., in the destruction of pests, which takes place immediately or only after some time has passed, for example during ecdysis, or indirectly, for example in a reduced oviposition and / or hatching rate.

[0209] Examples of the animal pests mentioned above are: of the order Acarina, for example, Acalitus spp, Aculus spp, Acaricalus spp, Aceria spp, Acarus siro, Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia spp, Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides spp, Eotetranychus spp, Eriophyes spp., Hemitarsonemus spp, Hyalomma spp., Ixodes spp., Olygonychus spp, Ornithodoros spp., Polyphagotarsone latus, Panonychus spp., Phyllocoptruta oleivora, Phytonemus spp, Polyphagotarsonemus spp, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Petition 870260073221, dated 23 / 07 / 2026, p. 95 / 259 90 / 240 Sarcoptes spp., Steneotarsonemus spp., Tarsonemus spp. from Tetranychus spp.; give order Anoplura, for example, Haematopinus spp., Linognathus spp., Pediculus spp. , Pemphigus spp. from Phylloxera spp.; of the order Coleoptera, for example, Agriotes spp., Amphimallon majale, Anomala orientalis, Anthonomus spp., Aphodius spp., Astylus atromaculatus, Ataenius spp., Atomaria linearis, Chaetocnema tibialis, Cerotoma spp., Conoderus spp., Cosmopolites spp., Cotinis nitida, Curculio spp., Cyclocephala spp., Dermestes spp., Diabrotica spp., Diloboderus abderus, Epilachna spp., Eremnus spp., Heteronychus arator, Hypothenemus hampei, Lagria vilosa, Leptinotarsa ​​decemlineata, Lissorhoptrus spp., Liogenys spp., Maecolaspis spp., Maladera castanea, Megascelis spp., Melighetes aeneus, Melolontha spp., Myochrous armatus, Orycaephilus spp., Otiorhynchus spp., Phyllophaga spp., Phlyctinus spp., Popillia spp., Psylliodes spp., Rhyssomatus aubtilis, Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Somaticus spp, Sphenophorus spp, Sternechus subsignatus, Tenebrio spp., Tribolium spp. and Trogoderma spp.; of the order Diptera, for example, Aedes spp., Anopheles spp, Antherigona soccata, Bactrocea oleae, Bibio hortulanus, Bradysia spp, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Delia spp, Drosophila melanogaster, Fannia spp., Gastrophilus spp., Geomyza tripunctata, Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia. Petition 870260073221, dated 23 / 07 / 2026, p. 96 / 259 91 / 240 hyoscyami, Phorbia spp., Rhagoletis spp., Rivelia quadrifasciata, Scatella spp., Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. from Onion spp.; give the order Hemiptera, for example Acanthocoris scabrator, Acrosternum spp, Adelphocoris lineolatus, Aleurodes spp., Amblypelta nitida, Bathycoelia thalassina, Blissus spp, Cimex spp., Clavigralla tomentosicollis, Creontiades spp, Distantiella theobroma, Dichelops furcatus, Dysdercus spp., Edessa spp, Euchistus spp., Eurydema pulchrum, Eurygaster spp., Halyomorpha halys, Horcias nobilellus, Leptocorisa spp., Lygus spp, Margarodes spp, Murgantia histrionic, Neomegalotomus spp, Nesidiocoris tenuis, Nezara spp., Nysius simulans, Oebalus insularis, Piesma spp., Piezodorus spp., Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophara spp., Thyanta spp, Triatoma spp., Vatiga illudens; Acyrthosium pisum, Adalges spp, Agalliana ensigera, Agonoscena targionii, Aleurodicus spp, Aleurocanthus spp, Aleurolobus barodensis, Aleurothrixus floccosus, Aleyrodes brassicae, Amarasca biguttula, Amritodus atkinsoni, Aonidiella spp., Aphididae, Aphis spp., Aspidiotus spp., Aulacorthum solani, Bactericera cockerelli, Bemisia spp, Brachycaudus spp, Brevicoryne brassicae, Cacopsylla spp, Cavariella aegopodii Scop., Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Cicadella spp, Cofana spectra, Cryptomyzus spp, Cicadulina spp, Coccus hesperidum, Dalbulus maidis, Dialeurodes spp, Diaphorina citri, Diuraphis noxia, Dysaphis spp, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Glycaspis brimblecombei, Hyadaphis pseudobrassicae, Hyalopterus spp, Hyperomyzus pallidus, Idioscopus clypealis, Jacobiasca Petition 870260073221, dated 23 / 07 / 2026, p. 97 / 259 92 / 240 lybica, Laodelphax spp., Lecanium corni, Lepidosaphes spp., Lopaphis erysimi, Lyogenys maidis, Macrosiphum spp., Mahanarva spp., Metcalfa pruinosa, Metopolophium dirhodum, Myndus crudus, Myzus spp., Neotoxoptera sp, Nephotettix spp., Nilaparvata spp., Nippolachnus piri Mats, Odonaspis ruthae, Oregma lanigera Zehnter, Parabemisia myricae, Paratrioza cockerelli, Parlatoria spp., Pemphigus spp., Peregrinus maidis, Perkinsiella spp, Phorodon humuli, Phylloxera spp., Planococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Pseudatomoscelis seriatus, Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Quesada gigas, Recilia dorsalis, Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Sogatella furcifera, Spissistilus festinus, Tarophagus Proserpina, Toxoptera spp., Trialeurodes spp., Tridiscus sporoboli, Trionymus spp., Trioza erytreae, Unaspis citri, Zygina flammigera, Zyginidia scutellaris, ; give the order Hymenoptera, for example Acromyrmex, Arge spp, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprion spp., Pogonomyrmex spp, Slenopsis invicta, Solenopsis spp. and Vespa spp.; of the order Isoptera, for example, Coptotermes spp, Corniternes cumulans, Incisitermes spp, Macrotermes spp, Mastotermes spp, Microtermes spp, Reticulitermes spp.; Solenopsis geminate of the order Lepidoptera, for example, Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyresthia spp, Argyrotaenia spp., Autographa spp., Bucculatrix thurberiella, Busseola fusca, Cadra Petition 870260073221, dated 23 / 07 / 2026, p. 98 / 259 93 / 240 cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Chrysoteuchia topiaria, Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Colias lesbia, Cosmophila flava, Crambus spp., Crocidolomia binotalis, Cryptophlebia leucotreta, Cydalima perspectalis, Cydia spp., Diaphania perspectalis, Diatraea spp., Diparopsis castanea, Earias spp., Elasmopalpus lignosellus, Eldana saccharina, Ephestia spp., Epinotia spp., Estigmene acrea, Etiella zinckinella, Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia jaculiferia, Grapholita spp., Hedya nubiferana, Heliothis spp., Hellula undalis, Herpetogramma spp., Hyphantria cunea, Keiferia lycopersicella, Lasmopalpus lignosellus, Leucoptera scitella, Lithocollethis spp., Lobesia botrana, Loxostege bifidalis, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Mythimna spp., Noctua spp., Operophtera spp., Orniodes indica, Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Papaipema nebris, Pectinophora gossypiela, Perileucoptera coffeella, Pseudaletia unipuncta, Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylostella, Prays spp., Pseudoplusia spp., Rachiplusia nu, Richia albicosta, Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodoptera spp., Sylepta derogate, Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni, Tuta absoluta, and Yponomeuta spp.;. give order Mallophaga, for example, Damalinea spp. from Trichodectes spp.; give the order Orthoptera, for example Petition 870260073221, dated 23 / 07 / 2026, p. 99 / 259 94 / 240 Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Neocurtilla hexadactyla, Periplaneta spp., Scapteriscus spp., and Schistocerca spp.; give the order Psocoptera, for example, Liposcelis spp.; order Siphonaptera, for example, Ceratophyllus spp., Ctenocephalides spp. from Xenopsylla cheopis; da ordem Thysanoptera, por exemplo, Calliothrips phaseoli, Frankliniella spp., Heliothrips spp, Hercinothrips spp., Parthenothrips spp, Scirtothrips aurantii, Sericothrips variabilis, Taeniothrips spp., Thrips spp; da ordem Thysanura, por exemplo, Lepisma saccharina.

[0210] In a further aspect, the invention may also relate to a method of controlling damage to plants and their parts by plant parasitic nematodes (endoparasitic, semiendoparasitic and ectoparasitic nematodes), especially plant parasitic nematodes such as root nodule nematodes, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica, Meloidogyne arenaria and other Meloidogyne species; cyst-forming nematodes, Globodera rostochiensis and other Globodera species; Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; seed-knot nematodes, Anguina species; stem and leaf nematodes, Aphelenchoides species; Stinging nematodes, Belonolaimus longicaudatus and other Belonolaimus species; Pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; Nematodes Petition 870260073221, dated 07 / 23 / 2026, p. 100 / 259 95 / 240 ring nematodes, Criconema species, Criconemella species, Criconemoides species, Mesocriconema species; Stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci and other Ditylenchus species; Boring nematodes, Dolichodorus species; Spiral nematodes, Heliocotylenchus multicinctus and other Helicotylenchus species; Sheathed nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; Lance-leaf nematodes, Hoploaimus species; False root-knot nematodes, Nacobbus species; Needle-like nematodes, Longidorus elongatus and other Longidorus species; Pine nematodes, Pratylenchus species; Lesion-forming nematodes, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus curvitatus, Pratylenchus goodeyi and other Pratylenchus species; Burrowing nematodes, Radopholus similis and other Radopholus species;Reniform nematodes, Rotylenchus robustus, Rotylenchus reniformis and other Rotylenchus species; Scutellonema species; Root shortening and thickening nematodes, Trichodorus primitivus and other Trichodorus species, Paratrichodorus species; Stunting nematodes, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species; Citrus nematodes, Tylenchulus species; Dagger-like nematodes, Xiphinema species; and other plant parasitic nematode species, such as Subanguina spp., Hypsoperine spp., Macroposthonia spp., Melinius spp., Punctodera spp. and Quinisulcius spp.; Petition 870260073221, dated 07 / 23 / 2026, page 101 / 259 96 / 240

[0211] The compounds of the invention may also have activity against molluscs. Examples of these include, for example, Ampullariidae; Arion (A. ater, A. circumscriptus, A. hortensis, A. rufus); Bradybaenidae (Bradybaena fruticum); Cepaea (C. hortensis, C. Nemoralis); ochlodina; Deroceras (D. agrestis, D. empiricorum, D. laeve, D. reticulatum); Discus (D. rotundatus); Euomphalia; Galba (G. trunculata); Helicelia (H. itala, H. obvia); Helicidae Helicigona arbustorum); Helicodiscus; Helix (H. aperta); Limax (L. cinereoniger, L. flavus, L. marginatus, L. maximus, L. tenellus); Lymnaea; Milax (M. gagates, M. marginatus, M. sowerbyi); Opeas; Pomacea (P. canaticulata); Vallonia and Zanitoides.

[0212] The active ingredients according to the invention can be used to control, i.e., contain or destroy, pests of the type mentioned above that occur in particular in plants, especially in useful plants and ornamental plants in agriculture, horticulture and forestry, or in organs such as fruits, flowers, foliage, stems, tubers or roots of such plants, and in some cases even the plant organs that are formed at a later time remain protected against these pests.

[0213] Suitable target crops are, in particular, cereals such as wheat, barley, rye, oats, rice, maize or sorghum; beet, such as sugar beet or fodder beet; fruit, for example pome fruit, stone fruit or soft fruit, such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries or blackberries; leguminous crops such as beans, lentils, peas or soybeans; oilseed crops such as rapeseed, mustard, poppies, olives, sunflowers, coconut, castor bean, cocoa or Petition 870260073221, dated 07 / 23 / 2026, p. 102 / 259 97 / 240 peanuts; cucurbits, such as pumpkins, cucumbers or melons; fibrous plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or tangerines; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes or peppers; Lauraceae, such as avocado, Cinnamonium or camphor; and also tobacco, nuts, coffee, eggplants, sugar cane, tea, pepper, vines, hops, the plantain family and latex plants.

[0214] In a particular embodiment, a compound of formula I or II controls mites, rust mites and spider mites in selected crops, trees and plants of vegetables and greens (especially tomatoes and cucurbits), citrus fruits, pome fruits, stone fruits, nuts, cotton, tropical crops, avocados, ornamental plants, beans, soybeans, strawberries and grapes.

[0215] The compositions and / or methods of the present invention can also be used in any ornamental and / or vegetable crops, including flowers, shrubs, broadleaf trees and evergreen trees.

[0216] For example, the invention can be used on any of the following ornamental species: Ageratum spp., Alonsoa spp., Anemone spp., Anisodontea capsenisis, Anthemis spp., Antirrhinum spp., Aster spp., Begonia spp. (e.g., B. elatior, B. semperflorens, B. tubereux), Bougainvillea spp., Brachycome spp., Brassica spp. (ornamental), Calceolaria spp., Capsicum annuum, Catharanthus roseus, Canna spp., Centaurea spp., Chrysanthemum spp., Cineraria spp. (C. maritime), Coreopsis spp., Crassula coccinea, Cuphea ignea, Dahlia spp., Delphinium spp., Dicentra spectabilis, Dorotheantus spp., Eustoma grandiflorum, Forsythia spp., Petition 870260073221, dated 07 / 23 / 2026, p. 103 / 259 98 / 240 Fuchsia spp., Geranium gnaphalium, Gerbera spp., Gomphrena globosa, Heliotropium spp., Helianthus spp., Hibiscus spp., Hortensia spp., Hydrangea spp., Hypoestes phyllostachya, Impatiens spp. (I. Walleriana), Iresines spp., Kalanchoe spp., Lantana camara, Lavatera trimestris, Leonotis leonurus, Lilium spp., Mesembryanthemum spp., Mimulus spp., Monarda spp., Nemesia spp., Tagetes spp., Dianthus spp. (cravo), Canna spp., Oxalis spp., Bellis spp., Pelargonium spp. (P. peltatum, P. Zonal), Viola spp. (love-perfect), Petunia spp., Phlox spp., Plectranthus spp., Poinsettia spp., Parthenocissus spp. (P. quinquefolia, P. tricuspidata), Primula spp., Ranunculus spp., Rhododendron spp., Rosa spp. (rose), Rudbeckia spp., Saintpaulia spp., Salvia spp., Scaevola aemola, Schizanthus wisetonensis, Sedum spp., Solanum spp., Surfinia spp., Tagetes spp., Nicotinia spp., Verbena spp., Zinnia spp. and other stratification plants.

[0217] For example, the invention can be used in any of the following species of legumes and vegetables: Allium spp. (A. sativum, A. cepa, A. oschaninii, A. Porrum, A. ascalonicum, A. fistulosum), Anthriscus cerefolium, Apium graveolus, Asparagus officinalis, Beta vulgarus, Brassica spp. (B. Oleracea, B. Pekinensis, B. rapa), Capsicum annuum, Cicer arietinum, Cichorium endivia, Cichorum spp. (C. intybus, C. endivia), Citrillus lanatus, Cucumis spp. (C. sativus, C. melo), Cucurbita spp. (C. pepo, C. maxima), Cyanara spp. (C. scolymus, C. cardunculus), Daucus carota, Foeniculum vulgare, Hypericum spp., Lactuca sativa, Lycopersicon spp. (L. esculentum, L. lycopersicum), Mentha spp., Ocimum basilicum, Petroselinum crispum, Phaseolus spp. (P. vulgaris, P. coccineus), Pisum sativum, Radish Petition 870260073221, dated 23 / 07 / 2026, p. 104 / 259 99 / 240 sativus, Rheum rhaponticum, Rosemarinus spp., Salvia spp., Scorzonera hispanica, Solanum melongena, Spinacea oleracea, Valerianella spp. (V. locusta, V. eriocarpa) and Vicia faba.

[0218] Preferred ornamental species include African violet, Begonia, Dahlia, Gerbera, Hydrangea, Verbena, Rose, Kalanchoe, Poinsettia, Aster, Centaurea, Coreopsis, Delphinium, Monarda, Phlox, Rudbeckia, Sedum, Petunia, Viola, Impatiens, Geranium, Chrysanthemum, Ranunculus, Fuchsia, Salvia, Hortensia, rosemary, sage, St. John's wort, mint, bell pepper, tomato and cucumber.

[0219] The active ingredients according to the invention are particularly suitable for controlling Aphis craccivora, Diabrotica balteata, Heliothis virescens, Myzus persicae, Plutella xylostella and Spodoptera littoralis in cotton, legumes and vegetables, corn, rice and soybean crops. The active ingredients according to the invention are further particularly suitable for controlling Mamestra (preferably in legumes and vegetables), Cydia pomonella (preferably in apples), Empoasca (preferably in vegetables, vineyards), Leptinotarsa ​​(preferably in potatoes) and Chilo suppressalis (preferably in rice).

[0220] The compounds of formula I or II are particularly suitable for controlling mites, spider mites and rust mites. In one embodiment, the compound of the invention TX (as defined below) is particularly suitable for controlling a selected pest from the groups of Acarapis spp; Acarapis woodi; Acarus siro; Acarus spp; Aceria sheldoni; Aculops pelekassi; Aculops spp; Aculus schlechtendali; Aculus spp; Amblyseius fallacis; Brevipalpus spp; Brevipalpus phoenicis; Bryobia praetiosa; Bryobia rubrioculus; Caloglyphus spp; Petition 870260073221, dated 07 / 23 / 2026, page 105 / 259 100 / 240 Cheyletiella blakei; Cheyletiella spp; Cheyletiella yasguri; Chorioptes bovis; Chorioptes spp; Cytodites spp; Demodex bovis; Demodex caballi; Demodex canis; Demodex caprae; Demodex equi; Demodex ovis; Demodex spp; Demodex suis; Dermanyssus gallinae; Dermanyssus spp; Eotetranychus spp; Eotetranychus willamettei; Epitrimerus pyri; Eriophyes ribis; Eriophyes spp; Eriophyes vitis; Eutetranychus spp; Halotydeus destructor; Hemitarsonemus spp; Knemidocoptes spp; Laminosioptes spp; Listrophorus spp; Myobia spp; Neoschongastia xerothermobia; Neotrombicula autumnalis; Neotrombicula desaleri; Notoedres cati; Notoedres spp; Oligonychus coffeae; Oligonychus ilicis; Oligonychus spp; Ornithocheyletia spp; Ornithonyssus bursa; Ornithonyssus spp; Ornithonyssus sylviarum; Otodectes cynotis; Otodectes spp; Panonychus citri; Panonychus spp; Panonychus elm; Phyllocoptruta oleivora; Phyllocoptruta spp.; Phytoseiulus spp.; Pneumonyssoides caninum; Polyphagotarsonemus latus; Polyphagotarsonemus spp; Psorergates ovis; Psorergates spp; Psoroptes cuniculi; Psoroptes equi; Psoroptes ovis; Psoroptes spp; Pterolichus spp; Raillietia spp; Rhizoglyphus spp; Sarcoptes bovis; Sarcoptes canis; Sarcoptes caprae; Sarcoptes equi; Sarcoptes ovis; Sarcoptes rupicaprae; Sarcoptes spp; Sarcoptes suis; Steneotarsonemus spinki; Steneotarsonemus spp; Sternostoma spp; Tarsonemus spp; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp; Tetranychus urticae; Trombicula akamushi; Trombicula spp; Typhlodromus occidentalis; Tyrophagus spp; Varroa jacobsoni; Varroa spp; Vasates lycopersici; and Zetzellia mali.

[0221] Um composto da invenção TX (como definito abaixo) é particularly adequado para controlar uma praga Petition 870260073221, dated 23 / 07 / 2026, p. 106 / 259 101 / 240 selected from the groups of Acalitus spp, Aculus spp, Acaricalus spp, Aceria spp, Acarus siro, Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia spp, Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides spp, Eotetranychus spp, Eriophyes spp., Hemitarsonemus spp, Hyalomma spp., Ixodes spp., Olygonychus spp, Ornithodoros spp., Polyphagotarsone latus, Panonychus spp., Phyllocoptruta oleivora, Phytonemus spp, Polyphagotarsonemus spp, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Steneotarsonemus spp, Tarsonemus spp. and Tetranychus spp.;

[0222] In one embodiment of the first aspect of the invention, the compound of the invention TX (as defined below) is suitable for the control of one or more of: Aceria sheldoni; Aculus lycopersici; Aculus pelekassi; Aculus schlechtendali; Brevipalpus phoenicis; Brevipalpus spp.; Bryobia rubrioculus; Eotetranychus carpini; Eotetranychus spp.; Epitrimerus pyri; Eriophyes piri; Eriophyes spp.; Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus citri; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp.; and Tetranychus urticae.

[0223] Um composto da invenção TX (como definido abaixo) is particularly suitable for controlling selected pests of Acanthocoris scabrator, Acrosternum spp, Adelphocoris lineolatus, Aleurodes spp., Amblypelta nitida, Bathycoelia thalassina, Blissus spp, Cimex spp., Clavigralla tomentosicollis, Creontiades spp, Distantiella theobroma, Dichelops furcatus, Dysdercus spp., Petition 870260073221, dated 23 / 07 / 2026, p. 107 / 259 102 / 240 Edessa spp, Euchistus spp., Eurydema pulchrum, Eurygaster spp., Halyomorpha halys, Horcias nobilellus, Leptocorisa spp., Lygus spp, Margarodes spp, Murgantia histrionic, Neomegalotomus spp, Nesidiocoris tenuis, Nezara spp., Nysius simulans, Oebalus insularis, Piesma spp., Piezodorus spp., Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophara spp., Thyanta spp., Triatoma spp., Vatiga illudens;

[0224] Acyrthosium pisum, Adalges spp, Agalliana ensigera, Agonoscena targionii, Aleurodicus spp, Aleurocanthus spp, Aleurolobus barodensis, Aleurothrixus floccosus, Aleyrodes brassicae, Amarasca biguttula, Amritodus atkinsoni, Aonidiella spp., Aphididae, Aphis spp., Aspidiotus spp., Aulacorthum solani, Bactericera cockerelli, Bemisia spp, Brachycaudus spp, Brevicoryne brassicae, Cacopsylla spp, Cavariella aegopodii Scop., Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Cicadella spp, Cofana spectra, Cryptomyzus spp, Cicadulina spp, Coccus hesperidum, Dalbulus maidis, Dialeurodes spp, Diaphorina citri, Diuraphis noxia, Dysaphis spp, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Glycaspis brimblecombei, Hyadaphis pseudobrassicae, Hyalopterus spp, Hyperomyzus pallidus, Idioscopus clypealis, Jacobiasca lybica, Laodelphax spp., Lecanium corni, Lepidosaphes spp., Lopaphis erysimi, Lyogenys maidis, Macrosiphum spp., Mahanarva spp, Metcalfa pruinosa, Metopolophium dirhodum, Myndus crudus, Myzus spp., Neotoxoptera sp, Nephotettix spp., Nilaparvata spp., Nippolachnus piri Mats, Odonaspis ruthae, Oregma lanigera Zehnter, Parabemisia myricae, Paratrioza cockerelli, Parlatoria spp., Pemphigus spp., Peregrinus maidis, Perkinsiella spp., Phorodon humuli,. Petition 870260073221, dated 23 / 07 / 2026, p. 108 / 259 103 / 240 Phylloxera spp, Pianococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Pseudatomoscelis seriatus, Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Quesada gigas, Recilia dorsalis, Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Sogatella furcifera, Spissistilus festinus, Tarophagus Proserpina, Toxoptera spp, Trialeurodes spp., Tridiscus sporoboli, Trionymus spp., Trioza erytreae, Unaspis citri, Zygina flammigera, and Zyginidia scutellaris.

[0225] The term cultures should be understood as also including culture plants that have been so transformed by the use of recombinant DNA techniques that they are capable of synthesizing one or more selectively acting toxins, such as are known, for example, from toxins produced by bacteria, especially those of the genus Bacillus.

[0226] Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins, for example insecticidal proteins from Bacillus cereus or Bacillus popilliae; or insecticidal proteins from Bacillus thuringiensis, such as δ-endotoxins, e.g., CrylAb, CrylAc, CrylF, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), e.g., Vipl, Vip2, Vip3 or Vip3A; or insecticidal proteins from nematode-colonizing bacteria, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus; Toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomyces toxins; plant lectins, such as pea lectins, barley lectins, or bellflower lectins. Petition 870260073221, dated 07 / 23 / 2026, page 109 / 259 104 / 240 white; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin inhibitors, cystatin, papain; ribosome-inactivating proteins (RIPs), such as ricin, maize RIP, abrin, lufin, saporin or briodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-UDP-glycosyltransferase, cholesterol oxidases, ecdysone inhibitors, HMG-CoA reductase, ion channel blockers, such as sodium or calcium channel blockers, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases.

[0227] In the context of the present invention, δ-endotoxins should be understood to mean, for example Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), for example Vip1, Vip2, Vip3 or Vip3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are recombinantly produced by a novel combination of different domains of these proteins (see, for example, WO 02 / 15701). Truncated toxins, for example a truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are substituted. In such amino acid substitutions, protease recognition sequences not naturally present are preferentially inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G recognition sequence is inserted into a Cry3A toxin (see WO 03 / 018810).

[0228] Examples of such toxins or transgenic plants capable of synthesizing such toxins are disclosed, by Petition 870260073221, dated 07 / 23 / 2026, page 110 / 259 105 / 240 example, in EP-A-0 374 753, WO 93 / 07278, WO 95 / 34656, EP-A0 427 529, EP-A-451 878 and WO 03 / 052073.

[0229] The processes for preparing such transgenic plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95 / 34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90 / 13651.

[0230] The toxin contained in transgenic plants confers tolerance to harmful insects on the plants. Such insects can occur in any taxonomic group of insects, but are especially commonly found in beetles (Coleoptera), two-winged insects (Diptera) and moths (Lepidoptera).

[0231] Transgenic plants containing one or more genes that encode insecticide resistance and express one or more toxins are known, and some of them are commercially available. Examples of such plants are: YieldGard® (a variety of maize that expresses a Cry1Ab toxin); YieldGard Rootworm® (a variety of maize that expresses a Cry3Bb1 toxin); YieldGard Plus® (a variety of maize that expresses a Cry1Ab and a Cry3Bb1 toxin); Starlink® (a variety of maize that expresses a Cry9C toxin); Herculex I® (a variety of maize that expresses a Cry1Fa2 toxin and the enzyme phosphinothricin N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (a variety of cotton that expresses a Cry1Ac toxin); Bollgard I® (cotton variety that expresses a Cry1Ac toxin); Bollgard II® (cotton variety that expresses a Cry1Ac and a Cry2Ab toxin); VipCot® (cotton variety that expresses a Vip3A and a Cry1Ab toxin); Petition 870260073221, dated 07 / 23 / 2026, page 111 / 259 106 / 240 NewLeaf® (a potato variety that expresses Cry3A toxin); NatureGard®, Agrisure® GT Advantage (glyphosate-tolerant GA21 trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait), and Protecta®.

[0232] Additional examples of such transgenic crops are: 1. Bt11 maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays that has been made resistant to attack by the European maize borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a truncated Cry1Ab toxin. Bt11 maize also transgenically expresses the PAT enzyme to achieve tolerance to the herbicide glufosinate ammonium. 2. Bt176 maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays that has been made resistant to attack by the European maize borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a Cry1Ab toxin. Bt176 maize also transgenically expresses the PAT enzyme to achieve tolerance to the herbicide glufosinate ammonium. 3. Maís MIR604 from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Maís that has been made insect-resistant by transgenic expression of a modified Cry3A toxin. This toxin is Cry3A055 modified by the insertion of a cathepsin G protease recognition sequence. The preparation of such transgenic maís plants is described in WO 03 / 018810. 4. Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number MON 863 Petition 870260073221, dated 07 / 23 / 2026, page 112 / 259 107 / 240 C / DE / 02 / 9. MON 863 expresses a Cry3Bb1 toxin and has resistance to certain Coleoptera insects. 5. IPC 531 Cotton from Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / ES / 96 / 02. 6. Maís 1507 from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium, registration number C / NL / 00 / 10. Maís genetically modified to express the Cry1F protein to achieve resistance to certain Ledidoptera insects and the PAT protein to achieve tolerance to the herbicide glufosinate ammonium. 7. Maís NK603 x MON 810 from Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / GB / 02 / M3 / 03. It consists of conventionally improved hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. Maís NK603 x MON 810 transgenically expresses the CP4 EPSPS protein, obtained from the CP4 strain of Agrobacterium sp., which confers tolerance to the herbicide Roundup® (contains glyphosate), and also a Cry1Ab toxin obtained from Bacillus thuringiensis subsp. kurstaki that confers tolerance to certain Lepidoptera, including the European corn borer.

[0233] Transgenic insect-resistant plant crops are also described in BATS (Zentrum für Biosicherheit und Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http: / / bats.ch).

[0234] The term crops should be understood as also including crop plants that have been so transformed by the use of recombinant DNA techniques that they are capable of synthesizing antipathogenic substances having a selective action, such as, for example, the so-called Petition 870260073221, dated 07 / 23 / 2026, page 113 / 259 108 / 240 “pathogenesis-related proteins” (PRPs, see, e.g., EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants capable of synthesizing such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95 / 33818 and EP-A-0 353 191. The methods of producing such transgenic plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above.

[0235] Crops can also be modified for enhanced resistance to fungal pathogens (e.g. Fusarium, Anthracnose or Phytophthora), bacterial pathogens (e.g. Pseudomonas) or viral pathogens (e.g. potato leafroll virus, tomato spotted wilt virus, cucurbit mosaic virus).

[0236] Crops also include those that have enhanced resistance to nematodes, such as the soybean cyst nematode.

[0237] Crops that are tolerant to abiotic stress include those that have enhanced tolerance to drought, high salt content, high temperature, glacial cold, frost, or light radiation, for example through the expression of NF-YB or other proteins known in the art.

[0238] Antipathogenic substances that can be expressed by such transgenic plants include, for example, ion channel blockers, such as sodium and calcium channel blockers, for example, the viral toxins KP1, KP4 or KP6; stilbene synthases; bibenzyl synthases; chitinases; glucanases; the so-called “pathogen-related proteins” (PRPs; see, e.g., EP-A-0 392 225); antipathogenic substances produced by microorganisms, for example, peptide antibiotics. Petition 870260073221, dated 07 / 23 / 2026, page 114 / 259 109 / 240 or heterocyclic antibiotics (see, e.g., WO 95 / 33818) or protein or polypeptide factors involved in plant defense against pathogens (so-called “plant disease resistance genes”, as described in WO 03 / 000906).

[0239] Additional areas of use of the compositions according to the invention are the protection of stored goods and warehouses and the protection of raw materials, such as wood, textiles, floor or building coverings, and also in the hygiene sector, in particular the protection of humans, domestic animals and farm animals against pests of the type mentioned.

[0240] The present invention provides a compound of the first aspect for use in therapy. The present invention provides a compound of the first aspect for use in controlling parasites in or on an animal. The present invention further provides a compound of the first aspect for use in controlling ectoparasites in an animal. The present invention further provides a compound of the first aspect for use in the prevention and / or treatment of diseases transmitted by ectoparasites.

[0241] The present invention provides the use of a compound from the first aspect for the manufacture of a medicament to control parasites in or on an animal. The present invention further provides the use of a compound from the first aspect for the manufacture of a medicament to control ectoparasites in an animal. The present invention further provides the use of a compound from the first aspect for the manufacture of a medicament to prevent and / or treat diseases transmitted by ectoparasites. Petition 870260073221, dated 07 / 23 / 2026, page 115 / 259 110 / 240

[0242] The present invention provides the use of a compound of the first aspect in the control of parasites in or on an animal. The present invention also provides the use of a compound of the first aspect in the control of ectoparasites on an animal.

[0243] The term “control” when used in the context of parasites in or on an animal refers to reducing the number of pests or parasites, eliminating pests or parasites and / or preventing infestations by additional pests or parasites.

[0244] The term “treat” when used in the context of parasites in or on an animal refers to restricting, slowing, stopping, or reversing the progression or severity of an existing symptom or disease.

[0245] The term “prevent” when used in the context of parasites in or on an animal refers to preventing a symptom or disease from developing in the animal.

[0246] The term “animal” when used in the context of parasites in or on an animal can refer to a mammal and a non-mammal, such as a bird or fish. In the case of a mammal, it can be a human or non-human mammal. Non-human mammals include, but are not limited to, farm animals and companion animals. Farm animals include, but are not limited to, cattle, camelids, pigs, sheep, goats, and horses. Companion animals include, but are not limited to, dogs, cats, and rabbits.

[0247] A “parasite” is a pest that lives in or on a host animal and benefits by deriving nutrients at the expense of the host animal. An “endoparasite” is a parasite that lives in the host animal. An “ectoparasite” is a parasite that lives on the host animal. Ectoparasites include, but are not limited to, mites, insects and Petition 870260073221, dated 07 / 23 / 2026, page 116 / 259 111 / 240 crustaceans (e.g., sea lice). The subclass Acari (or Acarina) comprises ticks and mites. Ticks include, but are not limited to, members of the following genera: Rhipicaphalus, for example, Rhipicaphalus (Boophilus) microplus and Rhipicephalus sanguineus; Amblyomma; Dermacentor; Haemaphysalis; Hyalomma; Ixodes; Rhipicentor; Margaropus; Argas; Otobius; and Ornithodoros. Mites include, but are not limited to, members of the following genera: Chorioptes, for example, Chorioptes bovis; Psoroptes, for example, Psoroptes ovis; Cheyletiella; Dermanyssus; for example Dermanyssus gallinae; Ortnithonyssus; Demodex, e.g. Demodex canis; Sarcoptes, for example Sarcoptes scabiei; and Psorergates. Insects include, but are not limited to, members of the orders: Siphonaptera, Diptera, Phthiraptera, Lepidoptera, Coleoptera, and Homoptera. Members of the order Siphonaptera include, but are not limited to, Ctenocephalides felis and Ctenocephalides canis. Members of the order Diptera include, but are not limited to, Musca spp.; Oestridae, for example Gasterophilus intestinalis and Oestrus ovis; biting flies; horseflies, for example Haematopota spp. and Tabunus spp.; Haematobia, for example, Haematobia irritans; Stomoxys; Lucilia; mangrove gnats; and mosquitoes. Members of the class Phthiraptera include, but are not limited to, blood-sucking lice and chewing lice, for example Bovicola ovis and Bovicola bovis.

[0248] The term “effective amount” when used in the context of parasites in or on an animal refers to the amount or dose of the compound of the invention, or a salt thereof, which, after single or multiple dose administration to the animal, provides the desired effect in or on the animal. A. Petition 870260073221, dated 07 / 23 / 2026, page 117 / 259 112 / 240 The effective amount can be readily determined by the attending physician, as an expert in the art, by using known techniques and by observing the results obtained under analogous circumstances. In determining the effective amount, a number of factors are considered by the diagnoser, including, but not limited to: the species of mammal; its size, age, and general health; the parasite to be controlled and the degree of infestation; the specific disease or dysfunction involved; the degree of involvement or severity of the disease or dysfunction; the individual's response; the particular compound administered; the mode of administration; the bioavailability characteristics of the administered preparation; the selected dosage regimen; the use of concomitant medication; and other relevant circumstances.

[0249] The compounds of the invention can be administered to the animal by any route that has the desired effect, including, but not limited to, topical, oral, parenteral, and subcutaneous.Topical administration is preferred. Suitable formulations for topical administration include, for example, solutions, emulsions, and suspensions, and may take the form of pour, spot application, spray, spray corridor, or immersion. Alternatively, the compounds of the invention may be administered via an ear tag or collar.

[0250] The salt forms of the compounds of the invention include both pharmaceutically acceptable and veterinary acceptable salts, which may differ from agrochemically acceptable salts. Pharmaceutically and veterinary acceptable salts and common methodologies for preparing them are well known in the art. See, for example, Gould, PL, “Salt selection for basic drugs”. Petition 870260073221, dated 07 / 23 / 2026, page 118 / 259 113 / 240 International Journal of Pharmaceutical Sciences, 33: 201-217 (1986); Bastin, RJ, et al. “Salt Selection and Optimization Procedures for Novel Pharmaceutical Entities”, Organic Process Research and Development, 4: 427-435 (2000); and Berge, SM, et al., “Pharmaceutical Salts”, Journal of Pharmaceutical Sciences, 66: 1-19 (1977). A person skilled in the art of synthesis will understand that the compounds of the invention are readily converted into and can be isolated as a salt, such as a hydrochloride salt, using techniques and conditions well known to the person skilled in the art. Additionally, a person skilled in the art of synthesis will understand that the compounds of the invention are readily converted into and can be isolated as the corresponding free base from the corresponding salt.

[0251] The present invention also provides a method for controlling pests (such as mosquitoes and other disease vectors; see also http: / / www.who.int / malaria / vector_control / irs / en / ). In one embodiment, the method for controlling pests comprises applying the compositions of the invention to the target pests, their locus, or a surface or substrate by brushing, rolling, spraying, spreading, or immersion. As an example, an IRS (internal residual spray) application to a surface, such as a wall, ceiling, or floor surface, is contemplated by the method of the invention. In another embodiment, it is contemplated applying such compositions to a substrate such as a nonwoven or woven material in the form of (or that can be used in the manufacture of) knitwear, clothing, bedding, curtains, and tents. Petition 870260073221, dated 07 / 23 / 2026, p. 119 / 259 114 / 240

[0252] In one embodiment, the method for controlling such pests comprises applying an effective amount of the compositions of the invention to the target pests, their locus, or a surface or substrate so as to provide effective residual pesticidal activity on the surface or substrate. Such application may be made by brushing, rolling, spraying, spreading, or immersing the pesticidal composition of the present invention. By way of example, an IRS application to a surface, such as a wall, ceiling, or floor surface, is contemplated by the method of the invention so as to provide effective residual pesticidal activity on the surface. In another embodiment, it is contemplated to apply such compositions for residual pest control to a substrate such as a woven material in the form of (or that can be used in the manufacture of) knitwear, clothing, bedding, curtains, and tents.

[0253] The substrates including nonwovens, wovens or knitted fabrics to be treated may be made of natural fibers such as cotton, raffia, jute, linen, sisal, plain warp or wool, or of synthetic fibers such as polyamide, polyester, polypropylene, polyacrylonitrile or similar. Polyesters are particularly suitable. Methods for treating textiles are known, e.g., from WO 2008 / 151984, WO 2003 / 034823, US 5631072, WO 2005 / 64072, WO2006 / 128870, EP 1724392, WO 2005113886 or WO 2007 / 090739.

[0254] Additional areas of use of the compositions according to the invention are the area of ​​tree injection / trunk treatment for all ornamental trees as well as all types of fruit trees and chestnut trees. Petition 870260073221, dated 07 / 23 / 2026, page 120 / 259 115 / 240

[0255] In the area of ​​tree injection / log treatment, the compounds according to the present invention are particularly suitable against wood-boring insects of the order Lepidoptera as mentioned above and of the order Coleoptera, especially against wood-boring insects listed in the following tables 2 and 3: Table 2. Examples of exotic wood drills of economic importance.______________________________________ Family Species Crop or Host Infested Buprestidae Agrilus planipennis Ash Cerambycidae Anoplura glabripennis Broadleaf trees Scolytidae Xylosandrus crassiusculus Broadleaf trees X. mutilatus Broadleaf trees Tomicus piniperda Conifers Table 3. Examples of native wood-boring plants of economic importance.______________________________________ Family Species Crop or Host Infested Buprestidae Agrilus anxius Birch Agrilus politus Willow, Maple Agrilus sayi Comptonia Agrilus vittaticollis Apple, Pear, Cranberry, Rowan, Hawthorn Chrysobothris femorata Apple, Apricot, Beech, Maple, Cherry, Chestnut, Currant Petition 870260073221, dated 07 / 23 / 2026, page 121 / 259 116 / 240 Family Species Crop or Host Infested Elm, Hawthorn, Hawthorn, Hyacinth, Horse Chestnut, Linden, Maple, Bird's-eye Oak, Oak, Pecan, Pear, Peach, Persimmon, Plum, Poplar, Quince, Judas Tree, Rowan, Plane Tree, Walnut, Willow Texania campestris Linden, Beech, Maple, Oak, Plane Tree, Willow, Yellow Poplar Cerambycidae Goes pulverulentus Beech, Elm, Nuttall Oak, Willow, Black Oak, Cherrybark Oak, Water Oak, Sycamore Goes tigrinus Oak Neoclytus acuminatus Ash, Hyacinth, Oak, Walnut, Birch, Beech, Maple, Ostrya virginiana, Dogwood, Persimmon, Judas Tree, Holly, Agreira, Robinia, Virginia Thorn, Petition 870260073221, dated 07 / 23 / 2026, p. 122 / 259 117 / 240 Family Species Crop or Host Infested Tulip tree, Chestnut, Osage orange, Sassafras, Lilac, Mountain mahogany, Pear, Cherry, Plum, Peach, Apple, Elm, American linden, Sweetgum Neoptychodes trilineatus Fig, Alder, Blackberry, Willow, Blackcurrant Oberea ocellata Sumac, Apple, Peach, Plum, Pear, Currant, Wild blackberry Oberea tripunctata Dogwood, Viburnum, Elm, Sorrel, Blueberry, Rhododendron, Azalea, Laurel, Poplar, Willow, Blackberry Oncideres cingulata Hibiscus, Pecan, Persimmon, Elm, Sorrel, Linden, Hawthorn, Dogwood, Eucalyptus, Oak, Agave, Maple, Fruit trees Saperda calcarata Poplar Petition 870260073221, dated 07 / 23 / 2026, p. 123 / 259 118 / 240 Family Species Crop or Host Infested Strophiona nitens Chestnut, Oak, Hyacinth, Walnut, Beech, Maple Corthylus Maple, Oak, Yellow poplar, Beech, Maple, Plane tree, Birch, American linden, Chestnut, Elm Dendroctonus frontalis Pine Dryocoetes betulae Birch, Sweetgum, Wild cherry, Beech, Pear Scolytidae Monarthrum Oak, Maple, Birch, fasciatum Chestnut, Liquid amber, Sour gum, Poplar, Hyacinth, Mimosa, Apple, Peach, Pine Phloeotribus Peach, Cherry, liminaris Plum, Black cherry, Elm, Blackberry, Mountain ash Pseudopityophthorus Oak, American beech, Black cherry, Plum Chickasaw, Chestnut, Petition 870260073221, dated 07 / 23 / 2026, pp. 124 / 259 119 / 240 Family Species Crop or Host Infested Maple, Honeydew, Hornbeam, Ostrya Sesiidae Paranthrene simulans Oak, American Chestnut Sannina uroceriformis Persimmon Synanthedon exitiosa Peach, Plum, Nectarine, Cherry, Apricot, Almond, Black Cherry Synanthedon pictipes Peach, Plum, Cherry, Beech, Black Cherry Synanthedon rubrofascia Tupelo Synanthedon scitula Dogwood, Pecan, Honeydew, Oak, Chestnut, Beech, Birch, Black Cherry, Elm, Mountain Ash, Viburnum, Willow, Apple, Loquat, Ninebark, Laurel Vitacea polistiformis Grape

[0256] The present invention can also be used to control any insect pests that may be present in grass, including for example beetles, Petition 870260073221, dated 07 / 23 / 2026, pp. 125 / 259 120 / 240 caterpillars, fire ants, ground pearls, millipedes, armadillos, mites, mole crickets, scale insects, mealybugs, leafhoppers, southern grass bugs, and white grubs. The present invention can be used to control insect pests at various stages of their life cycle, including eggs, larvae, nymphs, and adults.

[0257] In particular, the present invention can be used to control insect pests that feed on grass roots, including white grubs (such as Cyclocephala spp. (e.g., masked beetle, C. lurida), Rhizotrogus spp. (e.g., European beetle, R. majalis), Cotinus spp. (e.g., green St. John's beetle, C. nitida), Popillia spp. (e.g., Japanese beetle, P. japonica), Phyllophaga spp. (e.g., Asian garden beetle, M. castanea) and Tomarus spp., ground pearls (Margarodes spp.), mole crickets (orange, southern and short-winged; Scapteriscus spp., Gryllotalpa africana) and tipulas (common European midge, Tipula spp.).

[0258] The present invention can also be used to control insect pests of grass that inhabit the stem, including armyworms (such as fall armyworm, Spodoptera frugiperda, and grass caterpillar, Pseudaletia unipuncta), cutworms, weevils (Sphenophorus spp., such as S. venatus verstitus and S. parvulus) and grass moths (such as Crambus spp. and the tropical grass moth, Herpetogramma phaeopteralis).

[0259] The present invention can also be used to control grass insect pests that live above ground and feed on grass leaves, including stink bugs. Petition 870260073221, dated 07 / 23 / 2026, pp. 126 / 259 121 / 240 grasses (such as southern grass bugs, Blissus insularis), Bermuda grass mites (Eriophyes cynodoniensis), Rhodes grass mealybugs (Antonina graminis), two-lined leafhopper (Propsapia bicincta), leafhoppers, cutworms (family Noctuidae) and green aphids.

[0260] The present invention can also be used to control other grass pests such as imported red fire ants (Solenopsis invicta) that create ant mounds in the grass.

[0261] In the hygiene sector, the compositions according to the invention are active against ectoparasites such as hard ticks, soft ticks, scabies mites, trombiculid mites, flies (biting and licking), parasitic fly larvae, lice, head lice, bird lice and fleas. Examples of such parasites are:

[0262] From the order Anoplurida: Haematopinus spp., Linognathus spp., Pediculus spp. and Phtirus spp., Solenopotes spp.

[0263] Order Mallophagida: Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp. , Lepikentron spp., Damalina spp., Trichodectes spp. from Felicola spp..

[0264] From the order Diptera and the suborders Nematocerina and Brachycerina, for example Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia Petition 870260073221, dated 23 / 07 / 2026, p. 127 / 259 122 / 240 spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp. from Melophagus spp.

[0265] From the order Siphonapterida, for example Pulex spp. , Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp..

[0266] Of the order Heteropterida, for example Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp..

[0267] From the order Blattarida, for example Blatta orientalis, Periplaneta americana, Blattela germanica and Supella spp..

[0268] From the subclass Acaria (Acarida) and the orders Meta- and Meso-stigmata, for example Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp. and Varroa spp.

[0269] From the orders Actinedida (Prostigmata) and Acaridida (Astigmata), for example Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergatesspp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp. and Laminosioptes spp.

[0270] The compositions according to the invention are also suitable for protecting against insect infestations in the case of materials such as wood, textiles, plastics, adhesives, glues, paints, paper and cardboard, leather, floor and building coverings.

[0271] In a preferred embodiment of each aspect, a TX compound (as defined below) controls one or more Spodoptera littoralis, Plutella xylostella, Frankliniella Petition 870260073221, dated 07 / 23 / 2026, pp. 128 / 259 123 / 240 occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis includens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum Padia, and Chilo Suppressalis, such as Spodoptera littoralis + TX, Plutella xylostella + TX; Frankliniella occidentalis + TX, Thrips tabaci + TX, Euschistus heros + TX, Cydia pomonella + TX, Nilaparvata lugens + TX, Myzus persicae + TX, Chrysodeixis includens + TX, Aphis craccivora + TX, Diabrotica balteata + TX, Rhopalosiphum padi + TX, and Chilo suppressalis + TX.

[0272] In one modality, from each aspect, a compound TX is suitable for controlling Spodoptera littoralis, Plutella xylostella, Frankliniella occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis incIudens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum Padia, e Chilo Suppressalis em culturas de cottono, legumes e hortaliças, maís, cereal, arroz e soja

[0273] In one embodiment, a TX compound is suitable for controlling Mamestra (preferably in legumes and vegetables), Cydia pomonella (preferably in apples), Empoasca (preferably in legumes and vegetables, vineyards), Leptinotarsa ​​(preferably in potatoes) and Chilo suppressalis (preferably in rice).

[0274] The compounds according to the invention may possess any number of benefits including, inter alia, advantageous levels of biological activity to protect plants against insects or superior properties for use as agrochemical active ingredients (e.g., higher biological activity, an advantageous spectrum of activity, an enhanced safety profile (against non-target organisms)). Petition 870260073221, dated 07 / 23 / 2026, pp. 129 / 259 124 / 240 above and below ground (such as fish, birds and bees), enhanced physicochemical properties or enhanced biodegradability). In particular, it was surprisingly discovered that certain compounds of formula I or II may show an advantageous safety profile with respect to non-target arthropods, in particular pollinators such as honeybees, solitary bees and bumblebees. Most particularly, Apis mellifera.

[0275] The compounds according to the invention can be used as pesticidal agents in unmodified form, but are generally formulated in compositions in various modes using formulation adjuvants such as carriers, solvents and surfactants. The formulations can be in various physical forms, e.g., in the form of dusting powders, gels, wettable powders, water-dispersible granules, water-dispersible tablets, effervescent pellets, emulsifiable concentrates, microemulsifiable concentrates, oil-in-water emulsions, fluids in oil, aqueous dispersions, oily dispersions, suspoemulsions, capsule suspensions, emulsifiable granules, soluble liquids, water-soluble concentrates (with water or a water-miscible organic solvent as a carrier), impregnated polymer films or in other known forms, e.g., based on the Manual on Development and Use of FAO and WHO Specifications for Pesticides, United Nations, First Edition, Second Revision (2010). Such formulations can be used directly or diluted before use. Dilutions can be made, for example, with water, liquid fertilizers, micronutrients, biological organisms, oil or solvents. Petition 870260073221, dated 07 / 23 / 2026, pp. 130 / 259 125 / 240

[0276] Formulations can be prepared, for example, by mixing the active ingredient with the formulation excipients to obtain compositions in the form of finely divided solids, granules, solutions, dispersions or emulsions. Active ingredients can also be formulated with other excipients, such as finely divided solids, mineral oils, vegetable or animal oils, modified vegetable or animal oils, organic solvents, water, surfactants or combinations thereof.

[0277] The active ingredients may also be contained in very fine microcapsules. Microcapsules contain the active ingredients in a porous carrier. This allows the active ingredients to be released into the environment in controlled amounts (e.g., slow release). Microcapsules usually have a diameter of 0.1 to 500 microns. They contain active ingredients in an amount of about 25 to 95% by weight of the weight of the capsules. The active ingredients may be in the form of a monolithic solid, in the form of fine particles in solid or liquid dispersion, or in the form of a suitable solution. Encapsulating membranes may comprise, for example, natural or synthetic rubbers, cellulose, styrene / butadiene copolymers, polyacrylonitrile, polyacrylate, polyesters, polyamides, polyureas, polyurethane, or chemically modified polymers and starch xanthates or other polymers known to those skilled in the art.Alternatively, very fine microcapsules can be formed in which the active ingredient is contained in the form of finely divided particles in a solid matrix. Petition 870260073221, dated 07 / 23 / 2026, pp. 131 / 259 126 / 240 of base substance, but the microcapsules are not themselves encapsulated.

[0278] The formulation adjuvants that are suitable for the preparation of the compositions according to the invention are known per se. The following can be used as liquid carriers: water, toluene, xylene, petroleum ether, vegetable oils, acetone, methyl ethyl ketone, cyclohexanone, acid anhydrides, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl esters of acetic acid, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol abietate, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, diproxitol, alkylpyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, alpha-pinene, d-limonene, ethyl lactate,ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, gamma-butyrolactone, glycerol, glycerol acetate, glycerol diacetate, glycerol triacetate, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropylbenzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methylisoamyl ketone, methylisobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, methylene chloride, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate, oleic acid, oleylamine, o-xylene, phenol, Petition 870260073221, dated 07 / 23 / 2026, page 132 / 259 127 / 240 polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylene sulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol and higher molecular weight alcohols such as amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol, N-methyl-2-pyrrolidone and the like.

[0279] Suitable solid carriers are, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kieselguhr, limestone, calcium carbonate, bentonite, calcium montmorillonite, cottonseed husks, wheat flour, soy flour, pumice, wood flour, crushed walnut shells, lignin and similar substances.

[0280] A large number of surfactants can be advantageously used in both solid and liquid formulations, especially in those formulations that can be diluted with a carrier before use. Surfactants can be anionic, cationic, nonionic, or polymeric and can be used as emulsifiers, wetting agents, or suspending agents, or for other purposes. Typical surfactants include, for example, alkyl sulfate salts, such as diethanolammonium lauryl sulfate; alkylaryl sulfonate salts, such as calcium dodecylbenzenesulfonate; alkylphenol / alkylene oxide addition products, such as nonylphenol ethoxylate; alcohol / alkylene oxide addition products, Petition 870260073221, dated 07 / 23 / 2026, page 133 / 259 128 / 240 such as tridecyl alcohol ethoxylate; soaps, such as sodium stearate; alkylnaphthalenyl sulfonate salts, such as sodium dibutylnaphthalenyl sulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryltrimethylammonium chloride; polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; ethylene oxide and propylene oxide block copolymers; and mono- and dialkyl phosphate ester salts; and also additional substances described, e.g., in McCutcheon's Detergents and Emulsifiers Annual, MC Publishing Corp., Ridgewood, New Jersey (1981).

[0281] Additional adjuvants that may be used in pesticide formulations include crystallization inhibitors, viscosity modifiers, suspending agents, colorants, antioxidants, foaming agents, light absorbers, mixing aids, antifoaming agents, complexing agents, pH neutralizing or modifying substances and buffers, corrosion inhibitors, fragrances, wetting agents, absorption enhancers, micronutrients, plasticizers, glidants, lubricants, dispersants, thickeners, antifreeze, microbicides, and liquid and solid fertilizers.

[0282] The compositions according to the invention may include an additive comprising a vegetable or animal oil, a mineral oil, alkyl esters of such oils, or mixtures of such oils and oil derivatives. The amount of oil additive in the composition according to the invention is generally from 0.01 to 10%, based on the mixture to be applied. For example, the oil additive may be added to a tank. Petition 870260073221, dated 07 / 23 / 2026, pp. 134 / 259 129 / 240 spray at the desired concentration after a spray mixture has been prepared. Preferred oil additives comprise mineral oils or a vegetable oil, for example rapeseed oil, olive oil or sunflower oil, emulsified vegetable oil, alkyl esters of vegetable oils, for example methyl derivatives, or an animal oil, such as fish oil or beef tallow. Preferred oil additives comprise alkyl esters of C8-C22 fatty acids, especially methyl derivatives of C12-C18 fatty acids, for example, methyl esters of lauric acid, palmitic acid and oleic acid (methyl laurate, methyl palmitate and methyl oleate, respectively). Many oil derivatives are known from the Compendium of Herbicide Adjuvants, 10th Edition, Southern Illinois University, 2010.

[0283] The inventive compositions generally comprise from 0.1 to 99% by weight, especially from 0.1 to 95% by weight, of the compounds of the present invention and from 1 to 99.9% by weight of a formulation adjuvant which preferably includes from 0 to 25% by weight of a surfactant. Although commercial products may preferably be formulated as concentrates, the end user will normally employ diluted formulations.

[0284] Application rates vary within wide limits and depend on the nature of the soil, the application method, the crop plant, the pest to be controlled, the prevailing climatic conditions and other factors governed by the application method, the timing of application and the target crop. As a general guideline, compounds can be applied at a rate of 1 to 2000 L / ha, especially 10 to 1000 L / ha. Petition 870260073221, dated 07 / 23 / 2026, pp. 135 / 259 130 / 240

[0285] Preferred formulations may have the following compositions (% by weight): Table 4 Emulsifiable concentrates: Active ingredient: 1 to 95%, preferably 60 to 90%; Surfactant: 1 to 30%, preferably 5 to 20%; Liquid carrier: 1 to 80%, preferably 1 to 35% Table 5 Dust: Active ingredient: 0.1 to 10%, preferably 0.1 to 5%; solid carrier: 99.9 to 90%, preferably 99.9 to 99%. Table 6 Suspended concentrates: Active ingredient: 5 to 75%, preferably 10 to 50%; water: 94 to 24%, preferably 88 to 30%; surfactant: 1 to 40%, preferably 2 to 30% Table 7 Wettable powders: Active ingredient: 0.5 to 90%, preferably 1 to 80%; Surfactant: 0.5 to 20%, preferably 1 to 15%; Solid carrier: 5 to 95%, preferably 15 to 90%. Table 8 Granules: active ingredient: 0.1 to 30%, preferably 0.1 to 15% solid carrier: 99.5 to 70%, preferably 97 to 85%

[0286] The following examples further illustrate, but do not limit, the invention. Petition 870260073221, dated 07 / 23 / 2026, pp. 136 / 259 131 / 240 Table 9 Wettable powders a) b) c) active ingredients 25% 50% 75% sodium lignosulfonate 5% 5% sodium lauryl sulfate 3% 5% sodium diisobutylnaphthalenylsulfonate 6% 10% phenol polyethylene glycol ether (7-8 mol ethylene oxide) 2% highly dispersed silicic acid 5% 10% 10% kaolin 62% 27%

[0287] The combination is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, yielding wettable powders that can be diluted with water to give suspensions of the desired concentration. Table 10 Powders for dry seed treatment a) b) c) active ingredients 25% 50% 75% light mineral oil 5% 5% 5% highly dispersed silicic acid 5% 5% Kaolin 65% 40% Talc 20%

[0288] The combination is thoroughly mixed with the adjuvants and the mixture is completely ground in a suitable mill, resulting in powders that can be used directly for seed treatment. Table 11 Emulsifiable concentrate of active ingredients 10% Petition 870260073221, dated 07 / 23 / 2026, pp. 137 / 259 132 / 240 octylphenol polyethylene glycol ether (4-5 mol ethylene oxide) 3% calcium dodecylbenzenesulfonate 3% castor oil polyglycol ether (35 mol ethylene oxide) 4% cyclohexanone 30% xylene mixture 50%

[0289] Emulsions of any required dilution, which can be used for plant protection, can be obtained from this concentrate by dilution with water. Table 12 Dusts a) b) c) Active ingredients 5% 6% 4% Talc 95% Kaolin 94% Mineral filler 96%

[0290] Ready-to-use powders are obtained by mixing the combination with the carrier and grinding the mixture in a suitable mill. Such powders can also be used for dry seed coatings. Table 13 Extruder Granules Active Ingredients 15% Sodium lignosulfonate 2% Carboxymethylcellulose 1% Kaolin 82%

[0291] The mixture is mixed and ground with the adjuvants, and the mixture is moistened with water. The mixture is extruded and then dried in an air stream. Petition 870260073221, dated 07 / 23 / 2026, pp. 138 / 259 133 / 240 Table 14 Coated granules. Active ingredients: 8% polyethylene glycol (mol. w / w 200), 3% kaolin, 89%

[0292] The finely ground mixture is uniformly applied, in a mixer, to kaolin moistened with polyethylene glycol. Dust-free coated granules are obtained in this way. Table 15: Concentrate in suspension Active ingredients: 40% propylene glycol, 10% nonylphenol polyethylene glycol ether (15 mol ethylene oxide), 6% sodium lignosulfonate, 10% carboxymethylcellulose, 1% silicone oil (in the form of a 75% emulsion in water), 1% water, 32%

[0293] The finely ground mixture is intimately mixed with the adjuvants, giving a concentrated suspension from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, live plants, as well as plant propagation material, can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion. Petition 870260073221, dated 07 / 23 / 2026, pp. 139 / 259 134 / 240 Table 16: Flowable concentrate for seed treatment Active ingredients: 40% propylene glycol, 5% butanol PO / EO copolymer, 2% tristyrenephenol with 10-20 moles of EO, 2% 1,2-benzisothiazolin-3-one (as a 20% solution in water), 0.5% calcium salt of monoazo pigment, 5% silicone oil (as a 75% emulsion in water), 0.2% water, 45.3%

[0294] The finely ground mixture is intimately mixed with the adjuvants, giving a concentrated suspension from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, live plants, as well as plant propagation material, can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion. Slow-Release Capsule Suspension

[0295] 28 parts of the combination are mixed with 2 parts of an aromatic solvent and 7 parts of a mixture of toluene diisocyanate / polymethylene-polyphenyl isocyanate (8:1). This mixture is emulsified in a mixture of 1.2 parts polyvinyl alcohol, 0.05 parts antifoaming agent, and 51.6 parts water until the desired particle size is achieved. To this emulsion is added a mixture of 2.8 parts 1,6-diaminohexane in 5.3 parts water. The mixture is stirred until the reaction of Petition 870260073221, dated 07 / 23 / 2026, pp. 140 / 259 135 / 240 polymerization is complete. The resulting capsule suspension is stabilized by adding 0.25 parts of a thickener and 3 parts of a dispersing agent. The capsule suspension formulation contains 28% of the active ingredients. The average diameter of the capsules is 8-15 microns. The resulting formulation is applied to seeds as an aqueous suspension in an apparatus suitable for this purpose.

[0296] Formulation types include an emulsified concentrate (EC), a suspension concentrate (SC), a suspoemulsion (SE), a capsule suspension (CS), a water-dispersible granule (WG), an emulsifiable granule (EG), a water-in-oil emulsion (EO), an oil-in-water emulsion (EW), a microemulsion (ME), an oil dispersion (OD), an oil-miscible fluid (OF), an oil-miscible liquid (OL), a soluble concentrate (SL), an ultra-low volume suspension (SU), an ultra-low volume liquid (UL), a technical concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP), a soluble granule (SG), or any technically feasible formulation in combination with agriculturally acceptable adjuvants.

[0297] For the naming of the compounds of formulas I and II where X is O, the relative stereodescriptors of the Chemical Abstract Service were used. Describe the configuration of a cyclic molecule (including suitable polycyclic systems) with multiple stereogenic centers whereby the α side of the reference plane is the side on which the substituent with priority CIP resides in the lowest numbered stereogenic center. The other side is β. This type of nomenclature is well documented in the literature; see, for example, Pure & Appl. Chem. 1996, 68 112), 2193. Petition 870260073221, dated 07 / 23 / 2026, pp. 141 / 259 136 / 240

[0298] The following examples further illustrate, but do not limit, the invention. Those skilled in the art will readily recognize appropriate variations from the procedures, both in terms of reagents and reaction conditions and techniques.

[0299] Throughout this description, temperatures are given in degrees Celsius (°C). The following abbreviations are used: s = singlet; br s = wide singlet; d = doublet; br d = wide doublet; dd = double doublet; dt = double triplet; t = triplet, tt = triple triplet, q = quartet, quin = quintuplet, sept = septet; m = multiplet. Preparatory Examples: The device and the LC / MS and GC / MS methods are: Method 1:

[0300] Spectra were recorded on a Waters Mass Spectrometer (Single Quadripole Mass Spectrometer SQD, SQDII) equipped with an electrospray source (Polarity: positive and negative ions), Capillary: 3.00 kV, Cone range: 41 V, Extractor: 2.00 V, Source Temperature: 150 °C, Desolvation Temperature: 500 °C, Cone Gas Flow: 50 L / h, Desolvation Gas Flow: 1000 L / h, Mass Range: 110 to 800 Da) and a Waters Acquity UPLC: Binary pump, heated column compartment, diode array detector and ELSD detector. Column: UPLC HSS T3, 1.8 pm, 30 x 2.1 mm from Waters, Temp: 40 °C, PDA wavelength range (nm): 200 to 400, Solvent gradient: A = water + 5% acetonitrile + 0.1% HCOOH, B = acetonitrile + 0.05% HCOOH; gradient, B to 10-100% in 1.3 min; Flow rate (mL / min) 0.6. Method 2: Petition 870260073221, dated 07 / 23 / 2026, pp. 142 / 259 137 / 240

[0301] Spectra were recorded on a Trace 1310 Gas Chromatograph with a 1:1 split between the FID detector and an ISQ LT Single Quadrupole Mass Spectrometer. Injector temperature: 250 °C. Column: ZA-5 ms, 15 m, 0.25 mm diameter, 0.25 μm (Phenomenex) (GC conditions: initial temperature hold at 40 °C for 2 minutes followed by a gradient of 40 °C / min to 320 °C. Mass spectrometer conditions: EI with 70 eV, mass range: 50-650 Da). Method 3:

[0302] Spectra were recorded on a Trace 1310 Gas Chromatograph with a 1:1 split between the FID detector and an ISQ LT Single Quadrupole Mass Spectrometer. Injector temperature: 250 °C. Column: ZA-5 ms, 15 m, 0.25 mm diameter, 0.25 μm (Phenomenex) (GC conditions: initial temperature hold at 35 °C for 3 minutes followed by a gradient of 40 °C / min to 320 °C. Mass spectrometer conditions: CI with methane, mass range: 50-650 Da). Method 4:

[0303] Spectra were recorded on a GC 2010 PLUS (SHIMADZU), Column: SH-Rxi 17 Sil MS (L: 30 m, Thickness: 0.25 mm, diameter 0.25 mm), Column Oven Temp. (°C): 40, Injection Volume (mL): 0.1, Injection Temperature (°C): 250, Injection Mode: Division, Division Ratio: 50.0, Flow Control Mode: Pressure, Pressure (kPa): 48.0, Total Flow (mL / min): 52, Column Flow (mL / min): 1.0, Purge Flow (mL / min): 2.0, Linear Velocity (cm / sec): 35.7, Run Time: 15 min. Petition 870260073221, dated 07 / 23 / 2026, pp. 143 / 259 138 / 240 Table 17: Temperature program Rate Temperature (°C) Retention Time (min) 40 1.00 25 280 4.40

[0304] Mass Spectrometer: GCMS-QP2010Ultra (SHIMADZU), Ionization Mode: Electron Impact (EI), Source Temperature (°C): 200, Interface Temperature (°C): 220, Solvent Cutoff Time (min): 3.5, Detector Gain Mode: 0.0, Acquisition Mode: Scanning, Event Time (Sec): 0.30, Scanning Speed: 2500, Mass Range (m / z): 50-650. Method 5:

[0305] Spectra were recorded on a Waters Mass Spectrometer (SQD2 or QDA single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: Positive and Negative Polarity Exchange), Capillary: 0.8-3.00 kV, Cone range: 25, Source temperature: 120-150 °C, Desolvation temperature: 500-600 °C, Cone gas flow: 50 L / h, Desolvation gas flow: 1000 L / h, Mass range: 110 to 850 Da) and a Waters Acquity UPLC: Quaternary solvent manager, heated column compartment, diode array detector. Column: Acquity UPLC HSS T3 C18, 1.8 pm, 30 x 2.1 mm, Temp: 40 °C, DAD wavelength range (nm): 200 to 400, Solvent gradient: A = water + 5% acetonitrile + 0.1% HCOOH, B = acetonitrile + 0.05% HCOOH: gradient: 0 min B at 10%; 0.0-0.2 min B at 10-50%; 0.2-0.6 min B at 50-100%; Petition 870260073221, dated 07 / 23 / 2026, pp. 144 / 259 139 / 240 0.6–1.3 min B at 100%; 1.3–1.4 min B at 100–10%; 1.4–1.6 min B at 10%; Flow rate (mL / min) 0.6. Method 6:

[0306] Spectra were recorded on a Waters Corporation ACQUITY Mass Spectrometer (Single Quadrupole Mass Spectrometer SQD or SQDII) equipped with an electrospray source (Polarity: positive or negative ions, Capillary: 3.0 kV, Cone: 30 V, Extractor: 3.00 V, Source Temperature: 150 °C, Desolvation Temperature: 400 °C, Cone Gas Flow: 60 L / hr, Desolvation Gas Flow: 700 L / hr, Mass Range: 140 to 800 Da) and a Waters Corporation ACQUITY UPLC with solvent degasser, binary pump, heated column compartment and diode detector. Column: UPLC HSS T3, 1.8 μη, 30 x 2.1 mm from Waters, Temp: 60 °C, DAD wavelength range (nm): 210 to 400, Solvent gradient: A = Water / Methanol 9:1 + 0.1% formic acid, B = Acetonitrile + 0.1% formic acid, gradient: B 0-100% in 3.0 min; Flow rate (mL / min) 0.75. Example P1: Preparation of rel - (1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxamide (P1),nh2 H II (P1) Step A: Preparation of rel- (1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxylate ethyl (I-1) (I-1)

[0307] A stirred solution of copper sulfate (0.44 g, 2.8 mmol, 0.05 equiv.) in 3,4-dihydro-2H-pyran (24 mL) was Petition 870260073221, dated 07 / 23 / 2026, pp. 145 / 259 140 / 240 added at 82 °C, over a period of 2.5 hours using a syringe pump, a solution of ethyl 2-diazoacetate (6.5 mL, 56 mmol, 1.0 equiv.) in 3,4-dihydro-2Hpyran (10 mL) was added. The resulting reaction mixture was stirred under reflux for an additional 2 hours. After cooling to room temperature, diethyl ether (10 mL) was added to the reaction mixture and the resulting suspension was filtered through a PTFE syringe filter. The solvent was concentrated at room temperature under reduced pressure to yield rel-(1S,6S,7S)-2-oxabicyclo[4.1.0]heptane-7carboxylate ethyl (9.2 g) as a brown oil. GC-MS (method 3): retention time 7.50 min1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.07 - 4.15 (m, 2 H) 3.88 - 3.94 (m, 1 H) 3.57 - 3.65 (m, 1 H) 3.37 (td, J=11.08, 2.18 Hz, 1 H) 1.92 - 2.04 (m, 2 H) 1.72 - 1.78 (m, 2 H) 1.43 - 1.58 (m, 2 H) 1.23 - 1.28 (m, 3 H) Step B: Preparation of rel-(1S, 6S, 7S)-2oxabicyclo[4.1.0]heptane-7-carboxylic acid (I-2) (I-2)

[0308] To a solution of rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxylate ethyl (5.70 g, 33.5 mmol, 1.0 equiv.) in tetrahydrofuran (100 mL) and water (34 mL) was added lithium hydroxide monohydrate (3.27 g, 134 mmol, 4.0 equiv.). The reaction mixture was stirred at room temperature for 18 hours. Lithium hydroxide monohydrate (3.27 g, 134 mmol, 4.0 equiv.) was added again and stirred at room temperature for a further 4 hours. The reaction mixture was poured into water and extracted three times with ethyl acetate. The layer Petition 870260073221, dated 07 / 23 / 2026, pp. 146 / 259 Aqueous 141 / 240 was acidified with 4 M HCl and extracted three times with diethyl ether. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure. Trituration in pentane yielded rel-(1S,6S,7S)-2-oxabicyclo[4.1.0]heptane-7-carboxylic acid (2.30 g) as a white solid. GC-MS (method 3): retention time 7.40 min1H NMR (400 MHz, DMSO-d 6) δ ppm 12.05 (sl, 1 H) 3.70 (dd, J=7.08, 2.00 Hz, 1 H) 3.47 - 3.53 (m, 1 H) 3.20 - 3.31 (m, 1 H) 1.86 - 1.95 (m, 2 H) 1.57 - 1.64 (m, 2 H) 1.32 - 1.49 (m, 2 H) Step C: Preparation of rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxamide (P1) nh2o (P1)

[0309] In a closed flask, a mixture of rel-(1S,6S,7S) Ethyl 2-oxabicyclo[4.1.0]heptane-7-carboxylate (0.400 g, 2.35 mmol, 1.0 equiv.) and ammonium hydroxide (28% in water, 9.4 mL) were stirred at room temperature for 24 hours, then at 50 °C overnight. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Purification of the crude by flash chromatography (ethyl acetate in cyclohexane), followed by precipitation in diisopropyl ether and trituration in pentane, yielded rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxamide (0.118 g) as a beige solid. GC-MS (method 2): retention time 6.54 min 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 5.32 - 5.71 (m, 2 H) 3.89 (dd, J=7.27, 1.45 Hz, 1 H) 3.61 (dt, J=10.90, 3.09 Hz, Petition 870260073221, dated 07 / 23 / 2026, pp. 147 / 259 142 / 240 H) 3.38 (td, J=11.26, 1.82 Hz, 1 H) 1.95 - 2.05 (m, 2 H) 1.74 - 1.84 (m, 1 H) 1.51 - 1.61 (m, 2 H) 1.35 - 1.51 (m, 1 H) Example P2: Preparation of rel-(1S, 6S, 7S)-N-[2(methylcarbamoyl)phenyl]-2-oxabicyclo[4.1.0]heptane-7carboxamide (P2) (P2)

[0310] To a stirred solution of rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxylic acid (I-1) (0.300 g, 2.11 mmol, 1.0 equiv.) in ethyl acetate (32 mL) were added 2-amino-N-methylbenzamide (0.356 g, 2.32 mmol, 1.1 equiv.), 1-propanephosphonic anhydride (2.24 mL, 3.80 mmol, 1.80 equiv.) and N,N-diisopropylethylamine (1.11 mL, 6.33 mmol, 3.00 equiv.). The reaction mixture was stirred at room temperature overnight. It was then poured into a mixture of aqueous saturated water and sodium bicarbonate and extracted three times with diethyl ether. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the crude by flash chromatography (ethyl acetate in cyclohexane) yielded rel-(1S,6S,7S)-N-[2-(methylcarbamoyl)phenyl]-2oxabicyclo[4.1.0]heptane-7-carboxamide (0.400 g) as a white solid. LC-MS (method 1): retention time 0.73 min, m / z 275 [M+H]+.1H NMR (400 MHz, CHLOROFORM-d) δ ppm 11.19 (sl, 1 H) 8.52 (d, J=7.99 Hz, 1 H) 7.39 - 7.45 (m, 2 H) 7.01 - 7.06 (m, 1 H) 6.32 (sl, 1 H) 3.97 (dd, J=7.45, 1.63 Hz, 1 H) 3.61 3.68 (m, 1 H) 3.40 (td, J=10.72, 2.91 Hz, 1 H) 3.03 (d, Petition 870260073221, dated 07 / 23 / 2026, pp. 148 / 259 143 / 240 J=5.09 Hz, 3 H) 1.95 - 2.09 (m, 2 H) 1.84 - 1.91 (m, 1 H) 1.76 (dd, J=5.81, 1.45 Hz, 1 H) 1.44 - 1.62 (m, 2 H) Example P3: Preparation of rel-(1S,6S,7S)-N-(1-methyl-2-oxo-3-pyridyl)-2-oxabicyclo[4.1.0]heptane-7-carboxamide (P3) (P3)

[0311] To a stirred solution of rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxylic acid (I-1) (0.300 g, 2.11 mmol, 1.0 equiv.) in ethyl acetate (32 mL) were added (1-methyl-2-oxo-3-pyridyl)ammonium chloride (0.373 g, 2.32 mmol, 1.1 equiv.), 1-propanephosphonic anhydride (2.24 mL, 3.80 mmol, 1.80 equiv.) and N,N-diisopropylethylamine (1.30 mL, 7.39 mmol, 3.50 equiv.). The reaction mixture was stirred at room temperature overnight. It was then poured into a mixture of aqueous saturated water and sodium bicarbonate and extracted three times with diethyl ether. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the crude by flash chromatography (ethyl acetate in cyclohexane) yielded rel-(1S,6S,7S)N-(1-methyl-2-oxo-3-pyridyl)-2-oxabicyclo[4.1.0]heptane-7carboxamide (0.250 g) as a white solid. LC-MS (method 1): retention time 0.64 min, m / z 249 [M+H]+.1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.56 (sl, 1 H) 8.27 (dd, J=7.63, 1.82 Hz, 1 H) 6.96 (dd, J=6.90, 1.82 Hz, 1 H) 6.17 - 6.23 (m, 1 H) 3.94 - 3.98 (m, 1 H) 3.62 - 3.67 (m, 1 H) 3.61 (s, 3 H) 3.39 (td, J=11.26, 2.18 Hz, 1 H) 2.00 2.05 (m, 2 H) 1.83 - 1.89 (m, 1 H) 1.77 (dd, J=5.81, 1.82 Hz, 1 H) 1.43 - 1.63 (m, 2 H) Petition 870260073221, dated 07 / 23 / 2026, pp. 149 / 259 144 / 240 Example P4: Preparation of rel-(1S,6S,7S)-N-(2-oxo-1-phenyl3-pyridyl)-2-oxabicyclo[4.1.0]heptane-7-carboxamide (P4) (P4)

[0312] To a stirred solution of rel-(1S,6S,7S)-2oxabicyclo[4.1.0]heptane-7-carboxylic acid (0.320 g, 2.25 mmol, 1.0 equiv.) in ethyl acetate (34 mL) were added 3-amino-1-phenylpyridin-2-one (0.461 g, 2.48 mmol, 1.1 equiv.), 1-propanephosphonic anhydride (2.39 mL, 4.05 mmol, 1.80 equiv.) and N,N-diisopropylethylamine (1.39 mL, 7.88 mmol, 3.50 equiv.). The reaction mixture was stirred at room temperature overnight. It was then poured into a mixture of aqueous saturated water and sodium bicarbonate and extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the crude by flash chromatography (ethyl acetate in cyclohexane) yielded rel-(1S,6S,7S)N-(2-oxo-1-phenyl-3-pyridyl)-2-oxabicyclo[4.1.0]heptane-7carboxamide (0.400 g) as a white foam. LC-MS (method 1): retention time 0.83 min, m / z 311 [M+H]+.1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.58 (sl, 1 H) 8.36 (dd, J=7.27, 1.82 Hz, 1 H) 7.49 - 7.55 (m, 2 H) 7.42 - 7.49 (m, 1 H) 7.38 - 7.42 (m, 2 H) 7.05 (dd, J=6.90, 1.82 Hz, 1 H) 6.30 (t, J=7.27 Hz, 1 H) 3.98 (dd, J=7.45, 1.63 Hz, 1 H) 3.64 (dt, J=10.81, 3.13 Hz, 1 H) 3.40 (td, J=11.17, 2.00 Hz, 1 H) 1.98 - 2.07 (m, 2 H) 1.83 - 1.93 (m, 1 H) 1.75 (dd, J=5.81, 1.82 Hz, 1 H) 1.42 - 1.57 (m, 2 H) Petition 870260073221, dated 07 / 23 / 2026, pp. 150 / 259 145 / 240 Example P5: Preparation of (1α,6α,7α)-2,5dioxabicyclo[4.1.0]heptane-7-carboxamide (P5) THE NH The (P5) Step A: Preparation of (1α,6α,7α)-2,5dioxabicyclo[4.1.0]heptane-7-carboxylate ethyl (I-3) (I-3)

[0313] To a stirred solution of copper sulfate (0.068 g, 0.43 mmol, 0.05 equiv.) in 1,4-dioxene (1.6 mL) was added at 82 °C over a period of 2.5 hours using a syringe pump, a solution of ethyl 2-diazoacetate (1.0 mL, 8.6 mmol, 1.0 equiv.) in 1,4-dioxene (1.6 mL). The resulting reaction mixture was stirred under reflux for a further 2 hours. After cooling to room temperature, diethyl ether (10 mL) was added to the reaction mixture and the resulting suspension was filtered over a PTFE syringe filter. The solvent was concentrated at room temperature under reduced pressure to yield ethyl (1α,6α,7α)-2,5-dioxabicyclo[4.1.0]heptane-7-carboxylate (1.49 g) as a green oil. GC-MS (method 3): retention time 7.15 min 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.07 - 4.16 (m, 2 H) 3.95 (d, J=3.27 Hz, 2 H) 3.67 - 3.72 (m, 2 H) 3.60 - 3.66 (m, 2 H) 2.16 (t, J=3.09 Hz, 1 H) 1.22 - 1.27 (m, 3 H) Step B: Preparation of (1α,6α,7α)-2,5dioxabicyclo[4.1.0]heptane-7-carboxylic acid (I-4) Petition 870260073221, dated 07 / 23 / 2026, pp. 151 / 259 146 / 240 (I-4)

[0314] To a solution of (1α,6α,7α)-2,5dioxabicyclo[4.1.0]heptane-7-carboxylate ethyl (0.750 g, Lithium hydroxide monohydrate (0.426 g, 17.4 mmol, 4.0 equiv.) was added to tetrahydrofuran (10 mL) and water (10 mL). The reaction mixture was stirred at room temperature for 18 hours. Lithium hydroxide monohydrate (0.426 g, 17.4 mmol, 4.0 equiv.) was added again and stirred at room temperature for an additional 24 hours. The reaction mixture was poured into water and extracted three times with diethyl ether. The aqueous layer was acidified with 4 M HCl and extracted three times with diethyl ether. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure to yield (1α,6α,7α)-2,5-dioxabicyclo[4.1.0]heptane-7-carboxylic acid (0.370 g) as a white-yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.24 (sl, 1 H) 3.80 (d, J=2.91 Hz, 2 H) 3.59 (s, 4 H) 2.09 - 2.12 (m, 1 H) Step C: Preparation of (1α,6α,7α)-2,5-dioxabicyclo[4.1.0]heptane-7-carboxamide (P5) (P5)

[0315] In a closed flask, a mixture of (1α,6α,7α)-2,5-dioxabicyclo[4.1.0]heptane-7-carboxylate ethyl (0.750 g, 4.36 mmol, 1.0 equiv.) and ammonium hydroxide (28% in water, Petition 870260073221, dated 07 / 23 / 2026, pp. 152 / 259 The solution (147 / 240 mL) was stirred at room temperature for 24 hours, then at 50 °C overnight. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Purification of the crude by flash chromatography (ethyl acetate in cyclohexane) yielded (1α,6α,7α)-2,5-dioxabicyclo[4.1.0]heptane-7carboxamide (0.180 g) as a white solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 5.57 (sl, 2 H) 3.98 (d, J=2.91 Hz, 2 H) 3.68 - 3.75 (m, 2 H) 3.60 - 3.68 (m, 2 H) 1.98 (t, J=2.91 Hz, 1H) Example P6: Preparation of (1α,6α,7α)-(N-[2(methylcarbamoyl)phenyl]-2,5-dioxabicyclo[4.1.0]heptane-7carboxamide (P6)

[0316] To a stirred solution of (1R,6S)-2,5dioxabicyclo[4.1.0]heptane-7-carboxylic acid (I-4) (0.360 g, 2.50 mmol, 1.0 equiv.) in ethyl acetate (38 mL) were added 2-amino-N-methylbenzamide (0.421 g, 2.75 mmol, 1.1 equiv.), 1-propanephosphonic anhydride (2.65 mL, 4.50 mmol, 1.80 equiv.) and N,N-diisopropylethylamine (1.32 mL, 7.49 mmol, 3.00 equiv.). The reaction mixture was stirred at room temperature overnight. It was then poured into a mixture of aqueous saturated water and sodium bicarbonate and extracted three times with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the crude sample was performed by flash chromatography (ethyl acetate cycle). Petition 870260073221, dated 07 / 23 / 2026, pp. 153 / 259 148 / 240 hexane), then by reverse-phase chromatography (acetonitrile in water), yielded (1α,6α,7α)-2,5dioxabicyclo[4.1.0]heptane-7-carboxylic acid (0.135 g) as a red solid. LC-MS (method 1): retention time 0.64 min, m / z 277 [M+H]+.1H NMR (400 MHz, CHLOROPHORMIO-d) δ ppm 11.26 (sl, 1 H) 8.46 (d, J=7.99 Hz, 1 Hz, 7.48 - 7.46 m 2 H) 7.01 - 7.09 (m, 1 H) 6.34 (sl, 1 H) 4.05 (d, J=2.91 Hz, 2 H) 3.64 - 3.77 (m, 4 H) 3.02 (d, J=4.72 Hz, 3 H) 2.20 (t, J=2.91 Hz, 1 H). Table 18: Examples of compounds of formula (I): Entry Name IUPAC STRUCTURE TR (min) [M+H]+ or [M+] + (measurement) Method or NMR P1 rel- (1R,6R,7R ) -2oxabicicl o[4.1.0]h eptane-7carboxami da QyNHi 0 1H NMR (M+H]+ or [M+] δ ppm 5.32 - 5.71 (m, 2 H) 3.89 (dd, J=7.27, 1.4 5 Hz, 1 H) 3.61 (dt, J=10, 90, 3. 09 Hz, 1 H) 3.38 (td, J=11.26, 1.95 Hz - 1.95 Hz) 2.05 (m, 2 H) 1.74 - 1.84 (m, 1 H) 1.51 - 1.61 (m, 2 H) 1.35 - 1.51 (m, 1 H) Petition 870260073221, of 23 / 07 / 2026, p. 154 / 259 149 / 240 P2 rel- as, 6S,7S )-N-[2(methylcar bamoyl)fe nil]-2oxabicicl o[4.1.0]h eptane-7carboxami da / V °ds / NHH li r il 0.73 275 1 P3 rel- as, 6S,7S )-N-methyl-(1xoyl-pyr-2-3) oxabicicl o[4.1.0]h heptane-7carboxami da 0 0.4 249 1 P4 rel- (1S,6S,7S )-N-(2- oxo-1- phenyl-3- pyridyl) -2- a 3 jQ H II 0 0, 83 311 1 Petition 870260073221, of 23 / 07 / 2026, p. 155 / 259 150 / 240 oxabicicl o [4.1.0] h heptano-7carboxami to P5 (Ια,6α,7α )-2,5dioxabici cio[4.1.0 ]heptano- 7carboxami da c°yH 0-- / —X. .NH2 h II 0 2H NMR (400 MHz, CHLOROPHORMIO-d) δ ppm 5.57 (s 1.2 H) 3.98 (d, J=2.91 Hz, 2 H) 3.68 - 3.75 (m, 2 H) 3.60 - 3.66 m (1.98 H) (t, J=2.91 Hz, 1 H) P6 (la,6a,7a ) -(N- [2(methylcar bamoyl)phe nil]-2,5dioxabici clo[4.1.0 ]heptano- 7- carboxami da / °\χΗ H \ AH 0—.As. H 11 \ 1 7 7 | (Ια,6α,7α )-2,5- dioxabici clo[4.1.0 0— H II 0 2H NMR (400 MHz, CDCls) : d = 4.01 (d, J = 4 Hz, 2H), 3.76-3, 60 (m, 4 Petition 870260073221, dated 07 / 23 / 2026, pp. 156 / 259 151 / 240 ]heptane-7carboxyl CO H), 2.16 (t, J = 4 Hz, 1H) ppm. P8 (Ια,6α,7α )-2,5- Dioxabici cio[4.1.0 ]ethyl heptano7carboxylate HH 0 7, 18 172 4 P9 (la,6a,7a ) -li- me 111- 2,5- dioxabici clo[4.1.0 ]heptane- 7- carboxamide 0— H II 0 0, 18 158 5 PIO (la,6a,7a )-N,Ndimethyl- 2,5dioxabicyclo[4.1.0 ]heptane- 1 0— H ]| 0 0. 17 172 5 Petition 870260073221, dated 07 / 23 / 2026, pp. 157 / 259 152 / 240 7- carboxami da Pll (Ια,6α,7α ) -N- methyl-N(mtolyl)- 2,5dioxabicio[4.1.0 ]heptane- 7carboxami da < Λ । 0 —s' H li l· II 0 1, 03 248 5 P12 (Ια,6α,7α )-N-ethyl- N- (mtolyl)- 2,5dioxabici cio[4.1.0 ]heptane- 7carboxami da 0— * η \ || 0 1. 06 262 5 P13 (Ια,6α,7α ) -Nbenzyloxy -2,5- T —o / T o=\ ZI / __o 0. 97 250 5 Petition 870260073221, dated 07 / 23 / 2026, pp. 158 / 259 153 / 240 dioxabicicio[4.1.0 ]heptano7carboxami to P14 (Ια,6α,7α ) -N- [(2,6difluoroph enyl)metho xy]-2,5dioxabicicio[4.1.0 ]heptano- 7carboxami da \ Λ h I 0—t—JL HH [MHH] ! CDCls) : d =11, 15 (s, 1H), 7.58-7.46 (m, 1H), 7.22-7.10 (m, 2H), 4.88 (s, 2H), 3.72 (d, J = 4 Hz, 2H), 3.65- 3.49 (m, 4Hz, 2H), 3.65- 3.49 (m, 1, 82H), 1H) ppm. 19F NMR (400 MHz, CDCls) : -114.72 ppm. P15 (Ια,6α,7α ) -Netoxy- 2,5dioxabici cio[4.1.0 ]heptano- 7carboxami to H II 0 0.28 188 5 Petition 870260073221, of 23 / 07 / 2026, p. 159 / 259 154 / 240 P16 (Ια,6α,7α ) -Ν- (ιώtolyl)- 2,5- dioxabicicio[4.1.0 ]heptano- 7- carboxami to Λ°νΗ \ AH 0- / h ° XT 1, 01 234 5 P17 (la,6a,7-methylphenyl-2) -( 2,5dioxabic chlo[4.1.0 ]heptano- 7- carboxami to / V \ A h I 0— * 1 1, 07 252.07 6 P18 (la,6a,7a ) -N-(ptolyl)- 2,5- dioxabic chlo[4.1.0 ]heptano- 7- ν ν Η Η —N \ hl· il ° 1.03 234.08 6 Petition 870260073221, of 23 / 07 / 2026, p. 160 / 259 155 / 240 carboxami from P19 (Ια,6α,7α ) -Ν- [ (2,5dichlorophe nil)methyl ]-2,5dioxabici clo[4.1.0 ]heptane- 7carboxami from Cl Λ°νΗ Αί 0— η Ίι ΊΓ Ο CI 1, 19 301.98 6 P20 (la,6a,7a ) -N- (tetrahidrofura n-2ylmethyl) - 2,5dioxabici clo[4.1.0 ]heptano- 7carboxami from QvJd Η Η 0 0,58 228,08 6 P21 (la,6a,7a )-N-(2,5 — dimethylfe ί π ΥΥ ° 1, 07 248.1 6 Petition 870260073221, 07 / 23 / 2026, pág. 161 / 259 156 / 240 nil)-2,5dioxabici cio[4.1.0 ]heptano- 7- carboxami da P22 (la,6a,7a )-N-(1cyanocyclopropyl) - 2,5dioxabici clo[4.1.0 ]heptano- 7carboxami da / °\ Η N < XH / / / 0—ΓΧ / Ν\ / h ii \7 0 v 6 Petition 870260073221, 07 / 23 / 2026, pág. 162 / 259 157 / 240 P24 (Ια,6α,7α )-Ν-[ (4chloropheni 1)methyl]- 2,5-dioxabicic cio[4.1.0 ]heptano- 7-carboxamide 0 1.05 268.02 6 P25 (la,6a,7a ) -Ncicloprop 11-2,5dioxabicic clo[4.1.0 ]heptano 7carboxami da °' ΞΕ—O / IO=< 0.49 184.01 6 P26 (la,6a,7a )-N-(2pyridyl) - 2.5dioxabiclo[4.1.0 ]heptane- 7- CY \ AH * Η Γ |] 0 0.58 221.03 6 Petition 870260073221, dated 07 / 23 / 2026, pp. 163 / 259 158 / 240 carboxami of P27 (Ια,6α,7α ) -Νtetrahydrofura n-3-yl- 2,5dioxabicio[4.1.0 ]heptano- 7carboxami of Λ°νΗ \ / \ H 0— JH | p 0 1-- / 0.46 214.04 6 P28 (Ια,6α,7α ) -N- (cyclopropylmethyl) -2,5dioxabicic [4.1.0 ]heptane- 7carboxami da \ AHA o— H II o 0. 65 198.03 6 P29 (Ια,6α,7α )-N-(otolyl)- 2,5-dioxabici per . HT \ |1 0 0, 91 234.07 6 Petition 870260073221, dated 07 / 23 / 2026, pp. 164 / 259 159 / 240 cio[4.1.0 ]heptano- 7- carboxami da P30 (Iα,6α,7α )-N-(1metilpyrazol-311)-2,5dioxabicio[4.1.0 ]heptano- 7carboxami da í —о °=\ ZI rí 1 0,56 224,06 6 P31 (Iα,6α,7α ) -N- (cyclobut oxi )-2,5dioxabicio[4.1.0 ]heptano- 7- carboxami da \ Λ η / 7 Ο—Ν Η ° Ο 0, 68 214,04 6 P32 (Iα,6α,7α ) -Npyridazin -4-11- Λ°νΗ \ Λ Η o— η II ] ιι 0 0,44 221,98 6 Petition 870260073221, de 23 / 07 / 2026, pág. 165 / 259 160 / 240 2,5- dioxabici cio[4.1.0 ]heptano- 7-carboxami da P33 (Ia,6a,7a ) -Npyrazolo[ 1,5a]pyridin -2-11- 2,5dioxabici cio[4.1.0 ]heptano- 7carboxami da Λ°νH \ AH °—N H II vo V 0,86 260,06 6 P34 (Ia,6a,7a )-N-(1metilsulf onilazeti din-311)-2,5dioxabicio[4.1.0]heptano- 7-cy - 0—ΧΧ / Ν\ HY tX / ll^o 0 0.47 277.02 6 Petition 870260073221, de 23 / 07 / 2026, pág. 166 / 259 161 / 240 carboxami da P35 (Ια,6α,7α )-Ν-(3methyloxet an-3-yl)2,5dioxabici cio[4.1.0 ]heptano-7carboxami da / oo 0.48 214.03 6 P36 (la,6a,7a )-N-(1methylpyrazol-411)-2,5dioxabici CY clo[4.1.0]heptane-7carboxami. J 11 \ N— O 0.53 224.06 6 P37 (la,6a,7a ) -N- tetrahydropyra n-4-yl- 2,5- Λ°νΗ \ AH h II I 0 0.52 228.09 6 Petition 870260073221, dated 07 / 23 / 2026, pp. 167 / 259 162 / 240 P39 (Ια,6α,7α) ) -N- [ (2,4dichlorophenyl)methyl ]-2,5dioxabicic [4.1.0 ]heptane- 7carboxami da CV h ry01 0— HHT 0 Cl 1.23 301.98 6 Petition 870260073221, dated 07 / 23 / 2026, pp. 168 / 259 163 / 240 P40 (Ια,6α,7α )-Ν-[Ι- Ε (4chloropheni 1)propyl] -2,5-dioxabici cio[4.1.0 ]heptano- 7carboxami da CV h fYcl0 —N \ / XJ Η I 0 \ 1.28 296.06 6 P41 (1a,6a,7a ) -Nbenzyl- 2,5-dioxabici chloro[4.1.0 ]heptano- 7carboxami da 0 0.85 234.07 6 P42 (1a,6a,7a ) -N- (cyclopro pilmethoxy )-2,5- dioxabi chloro[4.1.0 ]heptano- \ AH °—t— ί Ύ °^v 0 v 0.7 214.02 6 Petition 870260073221, 07 / 23 / 2026, pág. 169 / 259 164 / 240 7- carboxami from

[0317] The activity of the compositions according to the invention can be considerably enhanced, and adapted to prevailing circumstances, by adding other active ingredients in terms of insecticides, acaricides and / or fungicides. Mixtures of the compounds of formula I or II with other active ingredients in terms of insecticides, acaricides and / or fungicides may also have surprising additional advantages which can also be described, in a broader sense, as synergistic activity. For example, better plant tolerance, reduced phytotoxicity, insects can be controlled at their different stages of development or better behavior during their production, for example during grinding or mixing, during their storage or during their use.

[0318] Suitable additions to active ingredients herein are, for example, representative of the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, ureas, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridinylmethyleneamino derivatives, macrolides, neonicotinoids and Bacillus thuringiensis preparations.

[0319] The list of TX compounds is published here, consisting of: A. compounds listed in Table 18; and B. compounds defined in Lists A-1 to A-36; and Petition 870260073221, dated 07 / 23 / 2026, pp. 170 / 259 165 / 240 C. compounds defined in Lists A-7 to A-36 (where formula IA is represented by formula Ia (when X is CH2, S, SO, SO2 or SO(NH)); and D. compounds defined in Lists A-1 to A-6 (where formula IA is represented by formula Iaa (when X is O)); and E. compounds defined in Lists B-7 to B-30 (where formula II-A is represented by formula IIa (when X is CH2, S, SO, SO2 or SO(NH)); and Faith G. compounds defined in Lists B-1 to B-6 (where formula II-A is represented by formula IIaa (when X is O)).

[0320] The present invention also makes available a mixture of a compound of the invention with another active agent (chemical or biological) in a weight ratio between 1 and 1. Accordingly, mixtures of a compound of the invention as defined by TX and an active agent (chemical or biological) in a weight ratio between 1 and 1 are disclosed herein as disclosed below in Listing A. List A an adjuvant selected from the group of substances consisting of petroleum oils (alternative name) (628) + TX; abamectin + TX, acequinocil + TX, acetamipride + TX, acetoprol + TX, acrinathrin + TX, acinonapyr + TX, afidopyropene + TX, afoxolaner + TX, alanicarbe + TX, allethrin + TX, alpha-cypermethrin + TX, alphamethrin + TX, amidoflumete + TX, aminocarbe + TX, azocyclotine + TX, bensultape + TX, benzoximate + TX, benzpyrimoxane + TX, betacyfluthrin + TX, beta-cypermethrin + TX, bifenazate Petition 870260073221, dated 07 / 23 / 2026, page. 171 / 259 166 / 240 + TX, bifenthrin + TX, binapacryl + TX, bioallethrin + TX, S-bioallethrin + TX, bioresmethrin + TX, bistriflurone + TX, broflanilide + TX, brofluthrinate + TX, bromophos-ethyl + TX, buprofezin + TX, butocarboxim + TX, cadusafos + TX, carbaryl + TX, carbosulfan + TX, cartape + TX, CAS number: 1632218-00-8 + TX, CAS number: 1808115-49-2 + TX, CAS number: 2032403-97-5 + TX, CAS number: 2044701-44-0 + TX, CAS number: 2128706-05-6 + TX, CAS number: 2095470-94-1 + TX, CAS number: 237708409-6 + TX, CAS number: 1445683-71-5 + TX, CAS number: 2408220-94-8 + TX, CAS number: 2408220-91-5 + TX, CAS number: 1365070-72-9 + TX, CAS number: 2171099-09-3 + TX, CAS number: 2396747-83-2 + TX, CAS number: 2133042-31-4 + TX, CAS number: 2133042-44-9 + TX, CAS number: 144568482-1 + TX, CAS number: 1445684-82-1 + TX, CAS number: 1922957-45-6 + TX, CAS number: 1922957-46-7 + TX, CAS number: 1922957-47-8 + TX, CAS number: 1922957-48-9 + TX, CAS number: 2415706-16-8 + TX, CAS number: 1594624-87-9 + TX,CAS number: 1594637-65-6 + TX, CAS number: 159462619-3 + TX, CAS number: 1990457-52-7 + TX, CAS number: 1990457-55-0 + TX, CAS number: 1990457-57-2 + TX, CAS number: 1990457-77-6 + TX, CAS number: 1990457-66-3 + TX, CAS number: 1990457-85-6 + TX, CAS number: 2220132-55-6 + TX, CAS number: 1255091-74-7 + TX, CAS number: 271984860-7 + TX, CAS number: 1956329-03-5 + TX, chlorantraniliprole + TX, chlordane + TX, chlorfenapyr + TX, chloropralethrin + TX, chromafenozide + TX, clenpyrine + TX, cloetocarbe + TX, clothianidin + TX, 2-chlorophenyl Nmethylcarbamate (CPMC) + TX, cyanofenphos + TX, cyantraniliprole + TX, cyclaniliprol + TX, cyclobutrifluram + TX, cycloprothrin + TX, cycloxapride, Petition 870260073221, dated 07 / 23 / 2026, page. 172 / 259 167 / 240 + TX, cyenopyrafen + TX, cietpyrafen (or etpyrafen) + TX, cyflumetofen + TX, cyfluthrin + TX, cialodiamide + TX, cyhalothrin + TX, cypermethrin + TX, cyphenothrin + TX, ciproflanilide + TX, cyromazine + TX, deltamethrin + TX, diafenthiuron + TX, dialifos + TX, dibrom + TX, dichloromesothiaz + TX, diflovidazin + TX, diflubenzuron + TX, dimpropyridaz + TX, dynactin + TX, dinocape + TX, dinotefuran + TX, dioxabenzophos + TX, emamectin (or emamectin benzoate) + TX, empentrin + TX, epsilonmomfluorothrin + TX, epsilon-metofluthrin + TX, esfenvalerate + TX, ethione + TX, ethiprol + TX, etofenprox + TX, etoxazol + TX, fanfur + TX, fenazaquin + TX, fenfluthrin + TX, phenmezodithiaz + TX, fenitrothion + TX, fenobucarb + TX, fenothiocarb + TX, fenoxicarb + TX, fenpropathrin + TX, fenpyroximate + TX, fensulfothion + TX, fenthion + TX, fentin acetate + TX, fenvalerate + TX, fipronil + TX, phlomethoquin + TX, flonicamid + TX, fluacripyrim + TX, fluazaindolizine + TX, fluazuron + TX,flubendiamide + TX, flubenzimine + TX, fluchlordiniliprole + TX, flucitrinate + TX, flucicloxuron + TX, flucitrinate + TX, fluensulfone + TX, flufenerim + TX, flufenprox + TX, flufiprol + TX, fluexafone + TX, flumethrin + TX, fluopiram + TX, flupentiofenox + TX, flupyradifuron + TX, flupyroxystrobin + TX, flupirimine + TX, fluralaner + TX, fluvalinate + TX, fluxamethamide + TX, fostiazato + TX, gamma-cyalothrin + TX, guadipir + TX, halofenozide + TX, halfenprox + TX, heptafluthrin + TX, hexitiazox + TX, hydramethylnon + TX, imiciafos + TX, imidacloprid + TX, imiprothrin + TX, indazapiroxamet + TX, indoxacarb + TX, iodomethane + TX, iprodione + TX, Petition 870260073221, dated 23 / 07 / 2026, p. 173 / 259 168 / 240 isocicloseram + TX, isothioate + TX, ivermectin + TX, capa-bifenthrin + TX, capa-tefluthrin + TX, lambdaCialothrin + TX, ledprone + TX, lepimectin + TX, lotilaner + TX, lufenuron + TX, metaflumizone + TX, metaldehyde + TX, metam + TX, methomyl + TX, methoxyfenozide + TX, metofluthrin + TX, metolcarb + TX, mexacarbate + TX, milbemectin + TX, momfluorothrin + TX, niclosamide + TX, nicofluprole + TX;nitenpyram + TX, nithiazine + TX, omethoate + TX, oxamyl + TX, oxazosulfyl + TX, parathion-ethyl + TX, permethrin + TX, phenothrin + TX, phosphocarb + TX, piperonylbutoxide + TX, pirimicarb + TX, pirimiphos-ethyl + TX, pirimiphos-methyl + TX, Vírus da polyhedrosis + TX, pralethrin + TX, profenofos + TX, profluthrin + TX, propargita + TX, propetanfos + TX, propoxur + TX, protiofos + TX, protrifenbuto + TX, piflubumide + TX, pymetrozine + TX, piraclofos + TX, pyrafluprol + TX, pyridaben + TX, pyridalil + TX, pyrifluquinazone + TX, pyrimifen + TX, pyriminostrobin + TX, pyriprol + TX, pyriproxyfen + TX, resmethrin + TX, sarolaner + TX, selamectin + TX, silaflufen + TX, spinetoram + TX, spinosad + TX, spirobudifen + TX;spirodiclofen + TX, spiromesifen + TX, spiropidione + TX, spirotetramate + TX, spidoxamate + TX, sulfoxaflor + TX, tebufenozide + TX, tebufenpyrad + TX, tebupirimifos + TX, tefluthrin + TX, temefos + TX, tetrachlorantraniliprol + TX, tetradifone + TX, tetramethrin + TX, tetramethylfluthrin + TX, tetranactin + TX, tetraniliprol + TX, tetracypermethrin + TX, thiacloprid + TX, thiamethoxam + TX, thiocyclam + TX, thiodicarb + TX, thiofanox + TX, thiomethone + TX, thiossultap + TX, tigolaner + TX, thioantraniliprol; Petition 870260073221, dated 07 / 23 / 2026, pp. 174 / 259 169 / 240 + TX; tioxazafen + TX, tolfenpyrad + TX, toxaphene + TX, tralomethrin + TX, transfluthrin + TX, triazamate + TX, triazophos + TX, trichlorphone + TX, trichloronate + TX, trichlorphone + TX, trifluenfuronate + TX, triflumezopyrim + TX, ticlopyrazflor + TX, zeta-cypermethrin + TX, Seaweed extract and fermentation product derived from molasses + TX, Seaweed extract and fermentation product derived from molasses comprising urea + TX, amino acids + TX, potassium and molybdenum and manganese chelated with EDTA + TX, Seaweed extract and fermented plant products comprising phytohormones + TX, vitamins + TX, copper chelated with EDTA + TX, zinc + TX and iron + TX, azadirachtin + TX, Bacillus aizawai + TX, Bacillus chitinosporus AQ746 (Accession No. NRRL B-21 618) + TX, Bacillus firmus + TX, Bacillus kurstaki + TX, Bacillus mycoides AQ726 (Accession No. NRRL B21664) + TX, Bacillus pumilus (Accession No. NRRL B30087) + TX, Bacillus pumilus AQ717 (N.or from Access NRRL B-21662) + TX, Bacillus sp. AQ178 (ATCC Accession No. 53522) + TX, Bacillus sp. AQ175 (ATCC Accession No. 55608) + TX, Bacillus sp. AQ177 (Accession No. ATCC 55609) + TX, Bacillus subtilis unspecified + TX, Bacillus subtilis AQ153 (Accession No. ATCC 55614) + TX, Bacillus subtilis AQ30002 (Accession No. NRRL B-521) + Bacillus subtilis, Bacillus subtilis TX1 AQ30004 (NRRL Accession No. B50455) + TX, Bacillus subtilis AQ713 (NRRL Accession No. B-21661) + TX, Bacillus subtilis AQ743 (NRRL Accession No. B-21665) + TX, Bacillus subtilis AQ743 (NRRL Accession No. 21665) B-21619) + TX, Bacillus thuringiensis BD#32 (NRRL Accession No. B-21530) + TX, Bacillus thuringiensis subspec. course BMP 123 + TX, Beauveria bassiana + TX,. Petition 870260073221, of 23 / 07 / 2026, p. 175 / 259 170 / 240 D-limonene + TX, Granulovirus + TX, Harpina + TX, Helicoverpa armigera nucleopolyhedrovirus + TX, Helicoverpa zea nucleopolyhedrovirus + TX, Heliothis virescens nucleopolyhedrovirus + TX, Heliothis punctigera nucleopolyhedrovirus + TX, Metarhizium spp. + TX, Muscodor albus 620 (Accession No. NRRL 30547) + TX, Muscodor roseus A3-5 (Accession No. NRRL 30548) + TX, Products based on the neem tree + TX, Paecilomyces futuroroseus + TX, Paecilomyces lilacinus + TX, Pasteuria nishizawae + TX, Pasteuria penetrans + TX, Pasteuria ramosa + TX, Pasteuria thornei + TX, Pasteuria usgae + TX, P-cymene + TX, Plutella xylostella granulosis virus + TX, Plutella xylostella nucleopolyhedrovirus + TX, Polyhedrosis virus + TX, pyrethrum + TX, QRD 420 (a mixture of terpenoids) + TX, QRD 452 (a mixture of terpenoids) + TX, QRD 460 (a mixture of terpenoids) + TX, Quillaja saponaria + TX, Rhodococcus globerulus AQ719 (N.Accession No. NRRL B-21663) + TX, Spodoptera frugiperda nucleopolyhedrovirus + TX, Streptomyces galbus (Accession No. NRRL 30232) + TX, Streptomyces sp. (Accession No. NRRL B-30145) + TX, Terpenoid mixture + TX and Verticillium spp. + TX; an algaecide selected from the group of substances consisting of betoxazine [CCN] + TX, copper dioctanoate (IUPAC name) (170) + TX, copper sulfate (172) + TX, cibutrin [CCN] + TX, diclona (1052) + TX, dichlorophene (232) + TX, endothal (295) + TX, fentin (347) + TX, hydrated lime [CCN] + TX, nabam (566) + TX, quinoclamine (714) + TX, quinonamide (1379) + TX, simazine (730) + TX, triphenyltin acetate (IUPAC name) Petition 870260073221, dated 07 / 23 / 2026, pp. 176 / 259 171 / 240 IUPAC) (347) + TX and triphenyltin hydroxide (IUPAC name) (347) + TX; an anthelmintic selected from the group of substances consisting of abamectin (1) + TX, crufomate (1011) + TX, cyclobutrifluram + TX, doramectin (alternative name) [CCN] + TX, emamectin (291) + TX, emamectin benzoate (291) + TX, eprinomectin (alternative name) [CCN] + TX, ivermectin (alternative name) [CCN] + TX, milbemycin oxime (alternative name) [CCN] + TX, moxidectin (alternative name) [CCN] + TX, piperazine [CCN] + TX, selamectin (alternative name) [CCN] + TX, spinosad (737) and thiophanate (1435) + TX; an avicide selected from the group of substances consisting of chloralose (127) + TX, endrin (1122) + TX, fenthione (346) + TX, pyridin-4-amine (IUPAC name) (23) + TX and strychnine (745) + TX; a bactericide selected from the group of substances consisting of 1-hydroxy-1H-pyridine-2-thione (IUPAC name) (1222) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, 8-hydroxyquinoline sulfate (446) + TX, bronopol (97) + TX, copper dioctanoate (IUPAC name) (170) + TX, copper hydroxide (IUPAC name) (169) + TX, cresol [CCN] + TX, dichlorophene (232) + TX, dipyrithione (1105) + TX, dodicine (1112) + TX, phenaminosulfe (1144) + TX, formaldehyde (404) + TX, hydragaphene (alternative name) [CCN] + TX, kasugamycin (483) + TX, hydrated kasugamycin hydrochloride (483) + TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308) + TX, nitrapyrin (580) + TX, octylinone (590) + TX, oxolinic acid (606) + TX, oxytetracycline (611) + TX, Petition 870260073221, dated 07 / 23 / 2026, pp. 177 / 259 172 / 240 potassium hydroxyquinoline sulfate (446) + TX, probenazole (658) + TX, streptomycin (744) + TX, streptomycin sesquisulfate (744) + TX, tecloftalam (766) + TX and thimerosal (alternative name) [CCN] + TX; a biological agent selected from the group of substances consisting of GV of Adoxophyes orana (alternative name) (12) + TX, Agrobacterium radiobacter (alternative name) (13) + TX, Amblyseius spp. (alternative name) (19) + TX, NPV of Anagrapha falcifera (alternative name) (28) + TX, Anagrus atomus (alternative name) (29) + TX, Aphelinus abdominalis (alternative name) (33) + TX, Aphidius colemani (alternative name) (34) + TX, Aphidoletes aphidimyza (alternative name) (35) + TX, NPV of Autographa californica (alternative name) (38) + TX, Bacillus firmus (alternative name) (48) + TX, Bacillus sphaericus Neide (scientific name) (49) + TX, Bacillus thuringiensis Berliner (scientific name) (51) + TX, Bacillus thuringiensis subsp. aizawai (scientific name) (51) + TX, Bacillus thuringiensis subsp. israelensis (scientific name) (51) + TX, Bacillus thuringiensis subsp. japonensis (scientific name) (51) + TX, Bacillus thuringiensis subsp. kurstaki (scientific name) (51) + TX, Bacillus thuringiensis subsp.tenebrionis (scientific name) (51) + TX, Beauveria bassiana (alternative name) (53) + TX, Beauveria brongniartii (alternative name) (54) + TX, Chrysoperla carnea (alternative name) (151) + TX, Cryptolaemus montrouzieri (alternative name). alternative name) (178) + TX, GV de Cydia pomonella (alternative name) (191) + TX, Dacnusa sibirica (alternative name) (212) + TX, Diglyphus isaea (alternative name) (254) + TX, Encarsia formosa (alternative name) Petition 870260073221, 07 / 23 / 2026, pág. 178 / 259 173 / 240 scientific) (293) + TX, Eretmocerus eremicus (alternative name) (300) + TX, NPV de Helicoverpa zea (alternative name) (431) + TX, Heterorhabditis bacteriophora e H. megidis (alternative name) (433) + TX, Hippodamia convergens (alternative name) (442) + TX, Leptomastix dactylopii (alternative name) (488) + TX, Macrolophus caliginosus (alternative name) (491) + TX, NPV de Mamestra brassicae (alternative name) (494) + TX, Metaphycus helvolus (alternative name) (522) + TX, Metarhizium anisopliae var. acridum (scientific name) (523) + TX, Metarhizium anisopliae var. anisopliae (scientific name) (523) + TX, NPV of Neodiprion sertifer and NPV of N. lecontei (alternative name) (575) + TX, Orius spp. (alternative name) (596) + TX, Paecilomyces fumosoroseus (alternative name) (613) + TX, Phytoseiulus persimilis (alternative name) (644) + TX, Spodoptera exigua multicapsid polyhedral virus (scientific name) (741) + TX, Steinernema bibionis (alternative name) (742) + TX, Steinernema carpocapsae (alternative name) (742) + TX, Steinernema feltiae (alternative name) (742) + TX, Steinernema glaseri (alternative name) (742) + TX, Steinernema riobrave (alternative name) (742) + TX, Steinernema riobravis (alternative name) (742) + TX, Steinernema scapterisci (alternative name) (742) + TX, Steinernema spp. (alternative name) (742) + TX, Trichogramma spp. (alternative name) (826) + TX Typhlodromus occidentalis (alternative name) (844) + TX and Verticillium lecanii (alternative name) (848) + TX; Petition 870260073221, dated 07 / 23 / 2026, pp. 179 / 259 174 / 240 a soil sterilizing agent selected from the group of substances consisting of iodomethane (IUPAC name) (542) + TX and methyl bromide (537) + TX; a chemosterifying agent selected from the group of substances consisting of afolate [CCN] + TX, bisazir (alternative name) [CCN] + TX, busulfan (alternative name) [CCN] + TX, diflubenzurone (250) + TX, dimatif (alternative name) [CCN] + TX, hemel [CCN] + TX, hempa [CCN] + TX, metepa [CCN] + TX, metiotepa [CCN] + TX, methyl afolate [CCN] + TX, morzide [CCN] + TX, penflurone (alternative name) [CCN] + TX, tepa [CCN] + TX, thio-hempa (alternative name) [CCN] + TX, thiotepa (alternative name) [CCN] + TX, tretamine (alternative name) [CCN] + TX and uredepa (alternative name) [CCN] + TX; an insect pheromone selected from the group of substances consisting of (E)-dec-5-en-1-yl acetate with (E)-dec-5-en-1-ol (IUPAC name) (222) + TX, (E)-tridec-4-en-1-yl acetate (IUPAC name) (829) + TX, (E)6-methyl-hept-2-en-4-ol (IUPAC name) (541) + TX, (E,Z)-tetradeca-4,10-dien-1-yl acetate (IUPAC name) (779) + TX, (Z)-dodec-7-en-1-yl acetate (IUPAC name) (285) + TX, (Z)-hexadec-11-enal (IUPAC name) (436) + TX, (Z)-hexadec-11-en-1-yl acetate (IUPAC name) IUPAC) (437) + TX, (Z)-hexadec-13-en-11-in-1-yl acetate (IUPAC name) (438) + TX, (Z)-icos-13-en-10-one (IUPAC name) (448) + TX, (Z)-tetradec-7-en-1-al (IUPAC name) (782) + TX, (Z)-tetradec-9-en-1-ol (IUPAC name) (783) + TX, (Z)-tetradec-9-en-1-yl acetate (IUPAC name) (784) + TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate (IUPAC name) (283) + TX, (9Z,11E)-tetradeca-9,11 Petition 870260073221, dated 07 / 23 / 2026, pp. 180 / 259 175 / 240 dien-1-yl (IUPAC name) (780) + TX, (9Z,12E)tetradeca-9,12-dien-1-yl acetate (IUPAC name) (781) + TX, 14-methyloctadec-1-ene (IUPAC name) (545) + TX, 4-methylnonan-5-ol with 4-methylnonan-5-one (IUPAC name) (544) + TX, alpha-multistriatin (alternative name) [CCN] + TX, brevicomine (alternative name) [CCN] + TX, codlelure (alternative name) [CCN] + TX, codlemone (alternative name) (167) + TX, cuelure (alternative name) (179) + TX, disparlure (277) + TX, dodec-8en-1-yl acetate (IUPAC name) (286) + TX, dodec-9-en-1-yl acetate (IUPAC name) (287) + TX, dodeca-8 + TX, 10-dien-1-yl acetate (IUPAC name) (284) + TX, dominicalure (alternative name) [CCN] + TX, ethyl 4-methyloctanoate (IUPAC name) (317) + TX, eugenol (alternative name) [CCN] + TX, frontin (alternative name) [CCN] + TX, Gossyplure® (alternative name;1:1 mixture of (Z,E) and (Z,Z) isomers of hexadeca-7,11-dien-1-yl acetate (420) + TX, grandlure (421) + TX, grandlure I (alternative name) (421) + TX, grandlure II (alternative name) (421) + TX, grandlure III (alternative name) (421) + TX, grandlure IV (alternative name) (421) + TX, hexalure [CCN] + TX, ipsdienol (alternative name) [CCN] + TX, ipsenol (alternative name) [CCN] + TX, japonilure (alternative name) (481) + TX, lineatin (alternative name) [CCN] + TX, litlure (alternative name) [CCN] + TX, looplure (alternative name) [CCN] + TX, medlure [CCN] + TX, megatomoic acid (alternative name) [CCN] + TX, methyl eugenol (alternative name) (540) + TX, muscalure (563) + TX, octadeca-2,13-dien-1-yl acetate (IUPAC name) (588) + TX, octadeca-3,13-dien-1-yl acetate (IUPAC name) (589) + TX, orfralure (name; Petition 870260073221, dated 07 / 23 / 2026, pp. 181 / 259 176 / 240 (alternative name) [CCN] + TX, orictalure (alternative name) (317) + TX, ostramona (alternative name) [CCN] + TX, siglure [CCN] + TX, sordidine (alternative name) (736) + TX, sulcatol (alternative name) [CCN] + TX, tetradec-11-en-1-yl acetate (IUPAC name) (785) + TX, trimedlure (839) + TX, trimedlure A (alternative name) (839) + TX, trimedlure B1 (alternative name) (839) + TX, trimedlure B2 (alternative name) (839) + TX, trimedlure C (alternative name) (839) TX and trunc-call (alternative name) [CCN] + TX; an insect repellent selected from the group of substances consisting of 2-(octylthio)ethanol (IUPAC name) (591) + TX, butopyronoxyl (933) + TX, butoxy(polypropylene glycol) (936) + TX, dibutyl adipate (IUPAC name) (1046) + TX, dibutyl phthalate (1047) + TX, dibutyl succinate (IUPAC name) (1048) + TX, diethyltoluamide [CCN] + TX, dimethyl carbate [CCN] + TX, dimethyl phthalate [CCN] + TX, ethyl hexanediol (1137) + TX, hexamide [CCN] + TX, methoquinonebutyl (1276) + TX, methylneodecanamide [CCN] + TX, oxamate [CCN] + TX and picaridin [CCN] + TX; a molluscicide selected from the group of substances consisting of bis(tributyltin) oxide (IUPAC name) (913) + TX, bromoacetamide [CCN] + TX, calcium arsenate [CCN] + TX, chloretocarb (999) + TX, copper acetoarsenite [CCN] + TX, copper sulfate (172) + TX, fentin (347) + TX, ferric phosphate (IUPAC name) (352) + TX, metaldehyde (518) + TX, methiocarb (530) + TX, niclosamide (576) + TX, niclosamide-olamine (576) + TX, pentachlorophenol (623) + TX, sodium pentachlorophenoxide (623) + TX, tazimcarb (1412) + TX, thiodicarb Petition 870260073221, dated 07 / 23 / 2026, pp. 182 / 259 177 / 240 (799) + TX, tributyltin oxide (913) + TX, trifenmorph (1454) + TX, trimetacarb (840) + TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347) + TX and pyriprole [394730-71-3] + TX; a nematicide selected from the group of substances consisting of AKD-3088 (compound code) + TX, 1,2-dibromo-3-chloropropane (IUPAC / Chemical Abstracts name) (1045) + TX, 1,2-dichloropropane (IUPAC / Chemical Abstracts name) Abstracts) (1062) + TX, 1,2-dichloropropane with 1,3-dichloropropene (IUPAC name) (1063) + TX, 1,3-dichloropropene (233) + TX, 1,1-dioxide of 3,4-dichlorotetrahydrothiophene (IUPAC / Chemical name) Abstracts) (1065) + TX, 3-(4-chlorophenyl)-5-methylrhodanine (IUPAC name) (980) + TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid (IUPAC name) (1286) + TX, 6-isopentenylaminopurine (alternative name) (210) + TX, abamectin (1) + TX, acetoprol [CCN] + TX, alanicarb (15) + TX, aldicarb (16) + TX, aldoxicarb (863) + TX, AZ 60541 (compound code) + TX, benclotiaz [CCN] + TX, benomyl (62) + TX, butylpyridaben (alternative name) + TX, cadusaphos (109) + TX, carbofuran (118) + TX, carbon disulfide (945) + TX, carbosulfan (119) + TX, chloropicrin (141) + TX, chlorpyrifos (145) + TX, cloetocarb (999) + TX, cyclobutrifluram + TX, cytokinins (alternative name) (210) + TX, dazomet (216) + TX, DBCP (1045) + TX, DCIP (218) + TX, diamidaphos (1044) + TX, diclofenthione (1051) + TX, diclifos (alternative name) + TX, dimethoate (262) + TX, doramectin (alternative name) [CCN] + TX, emamectin (291) + TX, emamectin benzoate (291) + Petition 870260073221, dated 07 / 23 / 2026, pp. 183 / 259 178 / 240 TX, eprinomectin (alternative name) [CCN] + TX, etoprophos (312) + TX, ethylene dibromide (316) + TX, fenamiphos (326) + TX, fenpyrad (alternative name) + TX, fensulfothione (1158) + TX, fosthiazate (408) + TX, fosthiethane (1196) + TX, furfural (alternative name) [CCN] + TX, GY-81 (development code) (423) + TX, heterophos [CCN] + TX, iodomethane (IUPAC name) (542) + TX, isamidophos (1230) + TX, isazophos (1231) + TX, ivermectin (alternative name) [CCN] + TX, kinetin (name alternative) (210) + TX, mecarphone (1258) + TX, metam (519) + TX, metam-potassium (alternative name) (519) + TX, metam-sodium (519) + TX, methyl bromide (537) + TX, methyl isothiocyanate (543) + TX, milbemycin oxime (alternative name) [CCN] + TX, moxidectin (alternative name) [CCN] + TX, Myrothecium verrucaria composition (alternative name) (565) + TX, NC-184 (compound code) + TX, oxamyl (602) + TX, phorate (636) + TX, phosphamidone (639) + TX, phosphocarb [CCN] + TX, sebufos (alternative name) + TX,selamectin (alternative name) [CCN] + TX, spinosad (737) + TX, terbam (alternative name) + TX, terbufos (773) + TX, tetrachlorothiophene (IUPAC / Chemical Abstracts name) (1422) + TX, thiafenox (alternative name) + TX, thionazine (1434) + TX, triazofos (820) + TX, triazurone (alternative name) + TX, xylenols [CCN] + TX, YI-5302 (compound code) + TX, zeatin (alternative name) (210) + TX, fluensulfone [318290-98-1] + TX and fluopyram + TX; a nitrification inhibitor selected from the group of substances consisting of potassium ethylxanthate [CCN] + TX and nitrapirin (580) + TX; Petition 870260073221, dated 07 / 23 / 2026, pp. 184 / 259 179 / 240 a plant activator selected from the group of substances consisting of acibenzolar (6) + TX, acibenzolar-S-methyl (6) + TX, probenazole (658) and Reynoutria sachalinensis extract (alternative name) (720) + TX; a rodenticide selected from the group of substances consisting of 2-isovalerilindan-1,3-dione (IUPAC name) (1246) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, alpha-chlorohydrin [CCN] + TX, aluminum phosphide (640) + TX, antu (880) + TX, arsenic oxide (882) + TX, barium carbonate (891) + TX, bistiosemi (912) + TX, brodifacoum (89) + TX, bromadiolone (including alpha-bromadiolone) + TX, bromethalin (92) + TX, calcium cyanide (444) + TX, chloralose (127) + TX, chlorophacinone (140) + TX, cholecalciferol (alternative name) (850) + TX, coumachlor (1004) + TX, coumafuril (1005) + TX, coumafuril (175) + TX, crimidine (1009) + TX, difenacoum (246) + TX, difethialone (249) + TX, difacinone (273) + TX, ergocalciferol (301) + TX, flocoumaphene (357) + TX, fluoroacetamide (379) + TX, flupropadine (1183) + TX, flupropadine hydrochloride (1183) + TX, gamma-HCH (430) + TX, HCH (430) + TX, hydrogen cyanide (444) + TX, iodomethane (IUPAC name) (542) + TX,lindane (430) + TX, magnesium phosphide (IUPAC name) (640) + TX, methyl bromide (537) + TX, norbormide (1318) + TX, phosacetin (1336) + TX, phosphine (IUPAC name) (640) + TX, phosphorus [CCN] + TX, pindone (1341) + TX, potassium arsenite [CCN] + TX, pirinurone (1371) + TX, esciliroside (1390) + TX, sodium arsenite [CCN] + TX, sodium cyanide (444) + TX, sodium fluoroacetate (735) + TX, Petition 870260073221, dated 07 / 23 / 2026, pp. 185 / 259 180 / 240 strychnine (745) + TX, thallium sulfate [CCN] + TX, warfarin (851) + TX and zinc phosphide (640) + TX; a synergist selected from the group of substances consisting of 2-(2-butoxyethoxy)ethyl piperonylate (IUPAC name) (934) + TX, 5-(1,3-benzodioxol-5-yl)-3hexylcyclohex-2-enone (IUPAC name) (903) + TX, farnesol with nerolidol (alternative name) (324) + TX, MB-599 (development code) (498) + TX, MGK 264 (development code) (296) + TX, piperonyl butoxide (649) + TX, piprotal (1343) + TX, propyl isomer (1358) + TX, S421 (development code) (724) + TX, sesamex (1393) + TX, sesasmolin (1394) + TX and sulfoxide (1406) + TX; an animal repellent selected from the group of substances consisting of anthraquinone (32) + TX, chloralose (127) + TX, copper naphthenate [CCN] + TX, copper oxychloride (171) + TX, diazinon (227) + TX, dicyclopentadiene (chemical name) (1069) + TX, guazatine (422) + TX, guazatine acetates (422) + TX, methiocarb (530) + TX, pyridin-4amine (IUPAC name) (23) + TX, thiram (804) + TX, trimetacarb (840) + TX, zinc naphthenate [CCN] + TX and ziram (856) + TX; a virucide selected from the group of substances consisting of imanin (alternative name) [CCN] and ribavirin (alternative name) [CCN] + TX; a wound protectant selected from the group of substances consisting of mercuric oxide (512) + TX, octilinone (590) and thiophanate-methyl (802) + TX, a biologically active substance selected from 1,1bis(4-chlorophenyl)-2-ethoxyethanol + TX, 2,4-dichlorophenyl benzenesulfonate + TX, 2-fluoro-N-methyl-N-1 Petition 870260073221, dated 07 / 23 / 2026, pp. 186 / 259181 / 240 naphthylacetamide + TX, 4-chlorophenylphenylsulfone + TX, acetoprol + TX, aldoxicarb + TX, amidione + TX, amidothioate + TX, amitone + TX, amitone hydrophenoxalate + TX, amitraz + TX, aramite + TX, arsenic oxide + TX, azobenzene + TX, azotoate + TX, benomyl + TX, benoxaphos + TX, benzyl benzoate + TX, bixaphene + TX, brofenvalerate + TX, bromocycline + TX, bromophos + TX, bromopropylate + TX, buprofezin + TX, butocarboxim + TX, butoxycarboxim + TX, butylpyridaben + TX, calcium polysulfide + TX, camphor + TX, carbanolate + TX, carbophenothione + TX, cimiazole + TX, quinomethionate + TX, chlorbenside + TX, chlordimeform + TX, chlordimeform hydrochloride + TX, chlorphenetol + TX, chlorfensone + TX, chlorfensulfide + TX, chlorobenzylate + TX, chloromebform + TX, chloromethiuron + TX, chloropropylate + TX, chlorthiophos + TX, cinerin I + TX, cinerin II + TX, cinerins + TX, closantel + TX, coumaphos + TX, crotamiton + TX, crotoxiphos + TX, kofraneb + ​​TX, cyantoate + TX, DCPM + TX,DDT + TX, demephione + TX, demephione-O + TX, demephione-S + TX, demethone-methyl + TX, demethone-O + TX, demethone-O-methyl + TX, demethone-S + TX, demethone-S-methyl + TX, demethone-S-methyl sulfone + TX, difluoride + TX + TX, dicliphos + TX, dienochlore + TX, dimefox + TX, dinex + TX, dinexdiclexin + TX, dinocape-4 + TX, dinocape-6 + TX, dinoctone + TX, dinopentone + TX, dinosulfone + TX, dinoterbona + TX, disulfone + disulphone, + TX, disulfiram + TX, DNOC + TX, dophenapine + TX, doramectin + TX, endothion + TX, eprinomectin + TX, etoate-methyl + TX, etrinphos + TX, phenazaflor + TX, fenbutatine oxide + TX, phenothiocarb + TX, fenpyrate + TX, Petition 870260073221, of 23 / 07 / 2026, p. 187 / 259 182 / 240 fenpyroximate + TX, fenpyrazamine + TX, fensone + TX, fentrifanil + TX, flubenzimine + TX, flucycloxuron + TX, flueneethyl + TX, fluorbenzide + TX, FMC 1137 + TX, formetanate + TX, formetanate hydrochloride + TX, formparanate + TX, gamma-HCH + TX, gliodin + TX, halfenprox + TX, hexadecyl cyclopropanecarboxylate + TX, isocarbofos + TX, jasmolin I + TX, jasmolin II + TX, iodfenphos + TX, lindane + TX, malonoben + TX, mecarbam + TX, mephospholane + TX, mesulfen + TX, metacrifos + TX, methyl bromide + TX, metolcarb + TX, mexacarbate + TX, milbemycin oxime + TX, mipafox + TX, monocrotophos + TX, morphothion + TX, moxidectin + TX, nalede + TX, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6iodo-3-pyridyl)methoxy]pyridazin-3-one + TX, nifluridide + TX, nicomycins + TX, nitrilacarb + TX, nitrilacarb complex 1:1 zinc chloride + TX, omethoate + TX, oxideprophos + TX, oxidisulfoton + TX, pp'-DDT + TX, parathion + TX, permethrin + TX, fencaptone + TX, phosalone + TX,phospholan + TX, phosphamidone + TX, polychloroterpenes + TX, polynactins + TX, proclonol + TX, promacil + TX, propoxur + TX, protidathion + TX, protoate + TX, pyrethrin I + TX, pyrethrin II + TX, pyrethrins + TX, TX, pyrithine + pyrethroid, + quinalphos + TX, quinthiophos + TX, R-1492 + TX, phosglycine + TX, rotenone + TX, escradane + TX, sebufos + TX, selamectin + TX, sofamide + TX, SSI-121 + TX, sulfiram + TX, sulfluramide + TX, sulfote + TX, envidone + TX + TX, tau-fluvalinate + TX, TEPP + TX, terbam + TX, tetradifone + TX, tetrasul + TX, thiaphenox + TX, thiocarboxyme + TX, thiophanox + TX, thiometone + TX, thioquinox + TX, thuringiensine + TX, TX + triamiphos, Petition 870260073221, of 23 / 07 / 2026, p. 188 / 259 183 / 240 triaratene + TX, triazophos + TX, triazurone + TX, trifenophos + TX, trinactin + TX, vamidothione + TX, vaniliprole + TX, bethoxazine + TX, copper dioctanoate + TX, copper sulfate + TX, cybutrin + TX, diclone + TX, dichlorophene + TX, endothal + TX, fentine + TX, lime hydrated + TX, nabam + TX, quinoclamine + TX, quinonamide + TX, simazine + TX, triphenyl stanho acetate + TX, triphenyl stanho hydroxide + TX, crufomate + TX, piperazine + TX, thiophanate + TX, chloralose + TX, fenthione + TX, pyridin-4-amine + TX, strychnine + TX, 1-hydroxy-1H-pyridine-2-thione + TX, 4(quinoxalin-2-ylamino)benzenosulfonamide + TX, 8-hydroxyquinoline sulfate + TX, bronopol + TX, copper hydroxide + TX, cresol + TX, dipyrithione + TX, dodicin + TX, phenaminosulfonate + TX, formaldehyde + TX, hydrargafen + TX, casugamycin + TX, casugamycin hydrochloride hydrate + TX, nickel bis(dimethyldithiocarbamate) + TX, nitrapyrine + TX, octylinone + TX, oxolinic acid + TX, oxytetracycline + TX,potassium hydroxiquinoline sulfate + TX, probenazol + TX, estreptomycin + TX, estreptomycin sesquissulfate + TX, tecloftalam + TX, thiomersal + TX, GV de Adoxophyes orana + TX, Agrobacterium radiobacter + TX, Amblyseius spp. + TX, NPV de Anagrapha falcifera + TX, Anagrus atomus + TX, Aphelinus abdominalis + TX, Aphidius colemani + TX, Aphidoletes aphidimyza + TX, NPV de Autographa californica + TX, Bacillus sphaericus Neide + TX, Beauveria brongniartii + TX, Chrysoperla carnea + TX, Cryptolaemus montrouzieri + TX, GV de Cydia pomonella + TX, Dacnusa sibirica + TX, Diglyphus isaea + TX, Encarsia formosa + TX, Eretmocerus eremicus + TX, Petition 870260073221, 07 / 23 / 2026, pág. 189 / 259 184 / 240 Heterorhabditis bacteriophora and H. megidis + TX, Hippodamia convergens + TX, Leptomastix dactylopii + TX, Macrolophus caliginosus + TX, NPV de Mamestra brassicae + TX, Metaphycus helvolus + TX, Metarhizium anisopliae var. acridum + TX, Metarhizium anisopliae var. anisopliae + TX, NPV of Neodiprion certifer and NPV of N. lecontei + TX, Orius spp. + TX, Paecilomyces fumosoroseus + TX, Phytoseiulus persimilis + TX, Steinernema bibionis + TX, Steinernema carpocapsae + TX, Steinernema feltiae + TX, Steinernema glaseri + TX, Steinernema riobrave + TX, Steinernema riobrave + TX, Steinernema riobrave, TX + TX, Steinernema spp. + TX, Trichogramma spp. + TX, Typhlodromus occidentalis + TX, Verticillium lecanii + TX, afolato + TX, bisazir + TX, bussulfan + TX, dimatif + TX, hemel + TX, hempa + TX, metepa + TX, metiotepa + TX, afolato de methyl + TX, morzida + TX, TX + pendulum, tefluna + TX thio-hemp + TX, thiotepa + TX, tretamine + TX, uredepa + TX,(E)-dec-5en-1-yl acetate with (E)-dec-5-en-1-ol + TX, (E)tridec-4-en-1-yl acetate + TX, (E)-6-methyl-hept-2-en-4-ol + TX, (E,Z)-dec-1-tetradeca-dien-4 acetate (Z)-dodec-7-en-1-ila + TX, (Z)-hexadec-11-enal + TX, acetate of (Z)-hexadec-11-en-1-ila + TX, acetate of (Z)hexadec-13-en-11-in-1-ila + TX, (0)-en-icos (Z)-tetradec-7-en-1-al + TX, (Z)-tetradec-9-en-1-ol + TX, acetate of (Z)-tetradec-9-en-1-yl + TX, acetate of (7E,9Z)-dodeca-7,9-diene-1-ylate + TX, acetate (9Z,11E)-tetradeca-9,11-diene-1-yl + TX, acetate of (9Z,12E)-tetradeca-9,12-diene-1-yl + TX, 14methylnoctadec-1-ene + TX, 4-methylnonano-5-ol com- TX-4methylnonane + TX Petition 870260073221, dated 07 / 23 / 2026, p. 190 / 259 185 / 240 brevicomine + TX, codlelure + TX, codlemona + TX, cuelure + TX, disparlure + TX, dodec-8-en-1-yl acetate + TX, dodec-9-en-1-yl acetate TX, dodeca-8-8 + TX-dominica acetate, acet TX, 4methyloctanoate + TX, eugenol + TX, frontalin + TX, grandlure + TX, grandlure I + TX, grandlure II + TX, grandlure III + TX, grandlure IV + TX, hexalure + TX, ipsdienol + TX, ipsenol, TX, linere + TX, japoneol + TX looplure + TX, medlure + TX, megatomoic acid + TX, methyl eugenol + TX, muscalure + TX, octadeca-2,13-diene-1-yl acetate + TX, octadeca-3,13-diene-1-yl acetate, oric + stralure + TX, TX siglure + TX, sordidine + TX, sulcatol + TX, tetradec-11en-1-yla acetate + TX, trimedlure + TX, trimedlure A + TX, trimedlure B1 + TX, trimedlure B2 + TX, trimedtanol C + TX, trunc-2-call), +( butopyronoxyl + TX, butoxy(polypropylenoglycol) + TX, dibutyl adipate + TX,dibutyl phthalate + TX, dibutyl succinate + TX, diethyltoluamide + TX, dimethylcarbamate + TX, dimethyl phthalate + TX, ethyl hexanediol + TX, hexamide + TX, methoquin-butyl + TX, methylneodecanamide + TX, oxamate + TX, picaridin + TX, 1-dichloro-1-nitroethane + TX, 1,1-dichloro-2,2-bis(4ethylphenyl)ethane + TX, 1,2-dichloropropane with 1,3dichloropropene + TX, 1-bromo-2-chloroethane + TX, 2,2,2trichloro-1-(3,4-dichlorophenyl)ethylacetate + TX, 2,2-dichlorovinyl-2-ethylsulfinylethylmethyl phosphate + TX, 2-(1,3-dithiolan-2-yl)phenyl dimethylcarbamate + TX, thiocyanate 2-(2-butoxyethoxy)ethyl + TX, methylcarbamate of 2-(4,5-dimethyl-1,3-dioxolan-2, Petition 870260073221, dated 23 / 07 / 2026, p. 191 / 259 186 / 240 yl)phenyl + TX, 2-(4-chloro-3,5-xylyloxy)ethanol + TX, 2-chlorovinyldiethyl phosphate + TX, 2-imidazolidone + TX, 2-isovaleryldan-1,3-dione + TX, methylcarbamate 2methyl(prop-2-inyl)aminophenyl + TX, 2thiocyanatoethyl laurate + TX, 3-bromo-1-chloroprop-1-eno + TX, dimethylcarbamate of 3-methyl-1-phenylpyrazol-5-yl + TX, methylcarbamate of 4-poxyl-2, + TX, 5,5-dimethyl-3-oxocyclo-hex-1enyl dimethylcarbamate + TX, acethion + TX, acrylonitrile + TX, aldrin + TX, allosamidine + TX, alixicarbe + TX, alpha-ecdysone + TX, aluminum phosphate + TX, + TX aminocarb, + TX atidationa + TX, azamethiphos + TX, delta endotoxins of Bacillus thuringiensis + TX, barium hexafluoroxylicate + TX, barium polysulfate + TX, bartrina + TX, Bayer 22 / 190 + TX, Bayer 22408 + TX, beta-cine + TXpertin, beta-Xpertin, + TX bioethanomethrin + TX, biopermethrin + TX, bis (2chloroethyl) ether + TX, borax + TX, bronfenvinphos + TX, bromo-DDT + TX, bufencarbe + TX,butacarb + TX, butatiofos + TX, butonate + TX, calcium arsenate + TX, calcium cyanide + TX, carbon disulfide + TX, carbon tetrachloride + TX, cartap hydrochloride + TX, cevadine + TX, chlorbicyclolene + TX, chlordane + TX, chlordecone + TX, chloroform + TX, chloropicrin + TX, chlorfoxime + TX, chlorprazophos + TX, cisresmethrin + TX, cismethrin + TX, clocitrin + TX, copper acetoarsenite + TX, copper arsenate + TX, copper oleate + TX, cumitoate + TX, cryolite + TX, CS 708 + TX, cyanophos + TX, cyanophos + TX, cyclothrin + TX, citrioate + TX, dtetramethrin + TX, DAEP + TX, dazomet + TX, decarbofuran + TX, diamidaphos + TX, dicaptone + TX, Petition 870260073221, dated 07 / 23 / 2026, pp. 192 / 259 187 / 240 diclofenthion + TX, dicresyl + TX, dicyclanil + TX, dieldrin + TX, diethyl-5-methylpyrazol-3-yl phosphate + TX, dilor + TX, dimefluthrin + TX, dimethan + TX, dimethrin + TX, dimethylvinphos + TX, dimethylane + TX, dinoprope + TX, dinosam + TX, dinosebe + TX, diofenolane + TX, dioxabenzophos + TX, diticrophos + TX, DSP + TX, ecdysterone + TX, EI 1642 + TX, EMPC + TX, EPBP + TX, etaphos + TX, ethiofencarb + TX, ethyl formate + TX, ethylene dibromide + TX, ethylene dichloride + TX, ethylene oxide + TX, EXD + TX, fenchlorphos + TX, fenetacarb + TX, fenitrothion + TX, fenoxacrim + TX, fenpyrithrin + TX, fensulfothion + TX, fenthion-ethyl + TX, flucofuron + TX, phosmethylan + TX, phospirate + TX, fosthietan + TX, furatiocarb + TX, furethrin + TX, guazatine + TX, guazatine acetates + TX, sodium tetrathiocarbonate + TX, halfenprox + TX, HCH + TX, HEOD + TX, heptachlor + TX, heterophos + TX, HHDN + TX, hydrogen cyanide + TX, hiquincarb + TX, IPSP + TX, isazophos + TX,isobenzane + TX, isodrine + TX, isofenphos + TX, isolane + TX, isoprothiolane + TX, isoxathione + TX, juvenile hormone I + TX, juvenile hormone II + TX, juvenile hormone III + TX, kelevan + TX, cynoprene + TX, lead arsenate + TX, leptofos + TX, lirinfos + TX, lithidathione + TX, m-cumenyl methylcarbamate + TX, magnesium phosphide + TX, mazidox + TX, mecarfone + TX, menazone + TX, mercury chloride + TX, mesulfenphos + TX, metam + TX, metam-potassium + TX, metamsodium + TX, methanesulfonyl fluoride + TX, metocrotofos + TX, methoprene + TX, methotrine + TX, methoxychlor + TX, methyl isothiocyanate + TX, methyl chloroform + TX, methylene chloride + TX, Petition 870260073221, dated 07 / 23 / 2026, pp. 193 / 259 188 / 240 methoxadiazone + TX, mirex + TX, naphthalophos + TX, naphthalene + TX, NC-170 + TX, nicotine + TX, nicotine sulfate + TX, nitiazine + TX, nornicotine + TX, O-5-dichloro-4-iodophenyl-O-ethyl ethylphosphonothioate + TX, O,O-diethyl-O-4-methyl-2-oxo-2Hcromen-7-yl phosphorothioate + TX, O,O-diethyl-O-6-methyl-2-propylpyrimidin-4-yl phosphorothioate + TX, O,O,O',O'-tetrapropyl dithiopyrophosphate + TX, oleic acid + TX, paradichlorobenzene + TX, methyl parathionine + TX, pentachlorophenol + TX, laurate pentachlorophenyl + TX, pH 60-38 + TX, fencaptone + TX, phosnichlore + TX, phosphine + TX, phosphine-methyl + TX, pyrimetaphos + TX, polychlorodicyclopentadiene isomers + TX, potassium arsenite + TX, potassium thiocyanate + TX, precocene I + TX, precocene II + TX, precocene III + TX, primidofos + TX, profluthrin + TX, promecarb + TX, protiofos + TX, pyrazophos + TX, pyresmethrin + TX, quassia + TX, quinolfos-methyl + TX, quinothione + TX, rafoxanide + TX, resmethrin + TX, rotenone + TX,cadetrina + TX, riânia + TX, rianodina + TX, sabadilla + TX, escradano + TX, sebufos + TX, SI-0009 + TX, tiapronil + TX, sodium arsenite + TX, sodium cyanide + TX, sodium fluoride + TX, sodium hexafluorosilicate + TX, sodium pentachlorophenoxide + TX, sodium selenate + TX, sodium thiocyanate + TX, sulcofurone + TX, sulcofurone-sodium + TX, sulfuryl fluoride + TX, sulprofos + TX, tar oils + TX, tazimcarb + TX, TDE + TX, tebupirinfos + TX, temefos + TX, teralethrin + TX, tetrachloroethane + TX, ticrofos + TX, thiocyclam + TX, thiocyclam hydrogen oxalate + TX, thionazine + TX, thiosultap + TX, thiosultap sodium + TX, tralometrian, Petition 870260073221, dated 07 / 23 / 2026, pp. 194 / 259 189 / 240 + TX, transpermethrin + TX, triazamate + TX, trichlormetaphos-3 + TX, tricloronate + TX, trimetacarb + TX, tolprocarb + TX, triclopiricarb + TX, triprene + TX, veratridine + TX, verathrin + TX, XMC + TX, zetamethrin + TX, zinc phosphate + TX, zolaprofos + TX, meperfluthrin + TX, tetramethylfluthrin + TX, bis(tributylstann) oxide + TX, bromoacetamide + TX, ferric phosphate + TX, niclosamide-olamine + TX, tributyltin oxide + TX, pyrimorph + TX, trifenmorph + TX, 1,2-dibromo-3-chloropropane + TX, 1,3-dichloropropene + TX, 1,1-dioxide of 3,4-dichlorotetrahydrothiophene + TX, 3-(4-chlorophenyl)-5-methylrhodan + TX, 5-methyl-6thioxo-1,3,5-thiadiazinan-3-ylacetic acid + TX, 6isopentenylaminopurine + TX, anisiflupurine + TX, benclotiaz + TX, cytokinins + TX, DCIP + TX, furfural + TX, isamidofos + TX, kinetin + TX, composition of Myrothecium verrucaria + TX, tetrachlorothiophene + TX, xylenóis + TX, zeatin + TX, potassium ethyl xanthate + TX, acibenzolar + TX,acibenzolar-S-methyl + TX, Reynoutria sachalinensis extract + TX, alpha-chlorohydrin + TX, antu + TX, barium carbonate + TX, bistiosemide + TX, brodifacoum + TX, bromadiolone + TX, bromethalin + TX, chlorophacinone + TX, cholecalciferol + TX, coumachlor + TX, coumafuryl + TX, coumatetralyl + TX, crimidine + TX, difenacoum + TX, difethialone + TX, difacinone + TX, ergocalciferol + TX, flocoumaphene + TX, fluoroacetamide + TX, flupropadine + TX, flupropadine hydrochloride + TX, norbormide + TX, fosacetin + TX, phosphorus + TX, pindone + TX, pirinurone + TX, esciliroside + TX, sodium fluoroacetate + TX, thallium sulfate + TX, warfarin + TX, 2-(2-butoxyethoxy)ethyl piperonylate, Petition 870260073221, dated 07 / 23 / 2026, pp. 195 / 259 190 / 240 + TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclo-hex-2-enone + TX, farnesol with nerolidol + TX, verbutin + TX, MGK 264 + TX, piperonyl butoxide + TX, piprotal + TX, propyl isomer + TX, S421 + TX, sesamex + TX, sesasmoline + TX, sulfoxide + TX, anthraquinone + TX, copper naphthenate + TX, copper oxychloride + TX, dicyclopentadiene + TX, thiram + TX, zinc naphthenate + TX, ziram + TX, imamine + TX, ribavirin + TX, chloroinconazid + TX, mercuric oxide + TX, thiophanatomethyl + TX, azaconazole + TX, biterethanol + TX, bromuconazole + TX, ciproconazole + TX, difenoconazole + TX, diniconazole + TX, epoxiconazole + TX, fenbuconazole + TX, fluquinconazole + TX, flusilazole + TX, flutriafol + TX, furametpir + TX, hexaconazole + TX, imazalil- + TX, imibenconazole + TX, ipconazole + TX, metconazole + TX, myclobutanil + TX, paclobutrazol + TX, pefurazoate + TX, penconazole + TX, prothioconazole + TX, pirifenox + TX, procloraz + TX, propiconazole + TX, pirisoxazole + TX, simeconazole + TX,tebuconazole + TX, tetraconazole + TX, triadimefon + TX, triadimenol + TX, triflumizole + TX, triticonazole + TX, ancimidol + TX, fenarimol + TX, nuarimol + TX, bupirimate + TX, dimethirimol + TX, ethirimol + TX, dodemorph + TX, fenpropidin + TX, fenpropimorph + TX, spiroxamine + TX, tridemorph + TX, cyprodinil + TX, mepanipyrim + TX, pyrimethanil + TX, fenpiclonil + TX, fludioxonil + TX, benalaxyl + TX, furalaxyl + TX, metalaxyl + TX, R-metalaxyl + TX, ofurace + TX, oxadixyl + TX, carbendazim + TX, debacarb + TX, fuberidazole -+ TX, thiabendazole + TX, clozolinato + TX, diclozolin + TX, miclozolin- + TX, procymidone + TX, vinclozolin + TX, boscalid + TX, carboxy + TX, Petition 870260073221, dated 23 / 07 / 2026, p. 196 / 259 191 / 240 fenfuram + TX, flutolanil + TX, mepronil + TX, oxycarboxin + TX, penthiopyrad + TX, thifluzamide + TX, dodine + TX, iminoctadine + TX, azoxystrobin + TX, dimoxystrobin + TX, enestroburin + TX, fenamistrobin + TX, flufenoxystrobin + TX, fluoxastrobin + TX, cresoxim-methyl + TX, metominostrobin + TX, trifloxystrobin + TX, orysastrobin + TX, picoxystrobin + TX, pyraclostrobin + TX, pyrametostrobin + TX, pyraoxystrobin + TX, ferbam + TX, mancozeb + TX, manebe + TX, metiram + TX, propineb + ​​TX, zineb + ​​TX, captafol + TX, captan + TX, fluoroimide + TX, folpet + TX, tolylfluanide + TX, Bordeaux mixture + TX, copper oxide + TX, mancobre + TX, oxine-copper + TX, nitrotal-isopropyl + TX, edifenphos + TX, iprobenphos + TX, phosphadifen + TX, tolclofos-methyl + TX, anilazine + TX, bentiavalicarb + TX, blasticidin-S + TX, chloronebe -+ TX, chlorothalonil + TX, cyflufenamide + TX, cymoxanil + TX, cyclobutrifluram + TX, diclocimete + TX, diclomesin + TX, dicloran + TX,dietofencarb + TX, dimethomorph + TX, flumorph + TX, dithianone + TX, etaboxam + TX, etridiazole + TX, famoxadone + TX, fenamidone + TX, fenoxanil + TX, ferimzone + TX, fluazinam + TX, flumethylsulforim + TX, fluopicolide + TX, fluoxythioconazole + TX, flusulfamide + TX, fluxapiroxad + TX, fenexamide + TX, fosetyl aluminum -+ TX, himexazol + TX, iprovalicarb + TX, cyazofamide + TX, metasulfocarb + TX, metrafenone + TX, pencicurone + TX, phthalide + TX, polyoxins + TX, propamocarb + TX, piribencarb + TX, proquinazide + TX, pyroquilone + TX, pyriofenone + TX, quinoxifene + TX, quintazene + TX, Petition 870260073221, dated 07 / 23 / 2026, pp. 197 / 259 192 / 240 thiadinyl + TX, triazoxide + TX, tricyclazole + TX, triforin + TX, validamycin + TX, valiphenalate + TX, zoxamide + TX, mandipropamide + TX, flubeneteram + TX, isopyrazam + TX, sedaxane + TX, benzovindiflupir + TX, . pyriflumethophen + TX, (3',4',5'-trifluoro-biphenyl-2yl)-amide of 3-difluoromethyl-1-methyl-1H-pyrazol4-carboxylic acid + TX, isoflucipram + TX, isothianil + TX, dipimetitron + TX, 6-ethyl-5,7-dioxopyrrolo[4,5][1,4]dithi-ino[1,2-c]isothiazole-3carbonitrile + TX, 2-(difluoromethyl)-N-[3-ethyl-1,1dimethyl-indan-4-yl]pyridine-3-carboxamide + TX,1. 4-(2,6difluorophenyl)-6-methyl-5-phenyl-pyridazine-3carbonitrile + TX, (R)-3-(difluoromethyl)-1-methyl-N[1,1,3-trimethyllindane-4-yl]pyrazol-4-carboxamide + TX, 4-(2,6difluorophenyl)-6-methyl-5-phenyl-pyridazine-3carbonitrile + TX, 4-(2,6difluorophenyl)-6-methyl-5-phenyl-pyridazine-3carbonitrile + TX, 4-(2,6difluorophenyl)-6-methyl-5-phenyl-pyridazine-3carbonitrile + TX, 4-(2,6difluorophenyl)-6-methyl-5-phenyl-pyridazine-3carbonitrile + TX 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)2,5-dimethyl-pyrazol-3-amine + TX, 4-(2-bromo-4fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1Hpyrazol-5-amine + TX, fluindapir + TX, cumethoxystrobin (jiaxiangjunzhi) + TX, lvbenmixianan + TX, diclobenthiazox + TX,mandestrobin + TX, 3-(4,4difluoro-3,4-di-hydro-3,3-dimethylsoquinoline-1yl)quinolone + TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3quinolyl)oxy]phenyl]propan-2-ol + TX, oxatiapi + TX,proline, N-[6-[[[(1-methyltetrazol-5-yl)-phenylmethylene]amino]oxymethyl]-2-pyridyl]tercbutyl carbamate + TX, pyraziflumide + TX, inpirfluxam + TX, trolprocarbe + TX, mefentrifluconazole + TX, ipfentri TX, conazole +, 2-(difluoromethyl)-N-[(3R)-3ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methylformamidine + TX, methanosulfonate of N'-(4,5,5) 870260073221, of 23 / 07 / 2026, p. 198 / 259, 193 / 240 dichlorothiazol-2-yl)oxi-2,5-dimethyl-fenil]-N-etil-Nmetil-formamidina + TX, [2-[3-[2-[1-[2-[3,5bis(difluorometil)pyrazol-1-yl]acetyl]-4piperidyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3chloro-fenil] + TX, N-[6-[[(Z)-[(1-metiltetrazol-5-il)fenil-methylene]amino]oximetil]-2-pyridyl]carbamato de but-3-inila + TX, N-[[5-[4-(2,4-dimethylfenil)triazol-2il]-2-metil-fenil]metil]carbamato de metil + TX, 3cloro-6-metil-5-fenil-4-(2,4,6trifluorofenil)pyridazine + TX piridaclometila + TX, 3(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4yl]pyrazole-4-carboxamide + TX, 1-[2-[[1-(4chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4methyl-tetrazol-5-one + TX, 1-methyl-4-[3-methyl-2-[[2methyl-4-(3,4,5-trimethylpyrazol-1yl)phenoxy]methyl]phenyl]tetrazol-5-one + TX, aminopyrifeno + TX, ametoctradina + TX, amissulbrom + TX, penflufeno + TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol3-yl]oxy-2-methoxy-imino-N,3-dimethyl-pent-3-enamide + TX, florilpicoxamide + TX, fenpicoxamide + TX, metarilpicoxamide + TX,tebufloquine + TX, ipflufenoquine + TX, quinofumelin + TX, isofetamide + TX, ethyl 1-[[4-[[2-(trifluoromethyl)-1,3-dioxolan-2-yl]methoxy]phenyl]methyl]pyrazole-3-carboxylate + TX (may be prepared from the methods described in WO 2020 / 056090), ethyl 1-[[4-[(Z)-2-ethoxy-3,3,3-trifluoroprop-1-enoxy]phenyl]methyl]pyrazole-3-carboxylate + TX (may be prepared from the methods described in WO 2020 / 056090), methyl N-[[4-[1-(4-cyclopropyl-2,6-difluorophenyl)pyrazole-4-yl]-2-methylphenyl]methyl]carbamate + TX (may be prepared from the methods, Petition 870260073221, dated 07 / 23 / 2026, pp. 199 / 259 194 / 240 described in WO 2020 / 097012), N-[[4-[1-(2,6-difluoro-4-isopropylphenyl)pyrazol-4-yl]-2-methylphenyl]methyl]methyl carbamate + TX (can be prepared from the methods described in WO 2020 / 097012), 6-chloro-3-(3-cyclopropyl-2-fluorophenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4-carboxamide + TX (can be prepared from the methods described in WO 2020 / 109391), 6-chloro-N-[2-(2-chloro-4-methylphenyl)-2,2-difluoroethyl]-3-(3-cyclopropyl-2-fluorophenoxy)-5-methylpyridazine-4-carboxamide + TX (can be prepared from the methods described in WO 2020 / 109391), 6-chloro-3-(3-cyclopropyl-2-fluorophenoxy)-N-[2-(3,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4-carboxamide + TX (can be prepared from the methods described in WO 2020 / 109391), N-[2[2,4-dichlorophenoxy]phenyl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide + TX, N-[2-[2-chloro-4(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1methyl-pyrazol-4-carboxamide + TX, benzothiostrobin + TX,fenamacryl + TX, zinc salt of 5-amino-1,3,4thiadiazole-2-thiol (2:1) + TX, fluopyram + TX, flufenoxadiazam + TX, flutianil + TX, fluopimomid + TX, pyrapropoin + TX, picarbutrazox + TX, 2(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4yl)pyridine-3-carboxamide + TX, 2-(difluoromethyl)-N((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3pyridyl]oxy]benzonitrile + TX, methyltetraprol + TX, 2(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4yl)pyridine-3-carboxamide + TX, α-(1,1-dimethylethyl)-αPetição 870260073221, de 23 / 07 / 2026, pág. 200 / 259, 195 / 240 [4'-(trifluoromethoxy) [1,1'-biphenyl]-4-yl]-5pyrimidinemethanol + TX, fluoxapiproline + TX, enoxastrobin + TX, methyl (Z)-3-methoxy-2-[2-methyl-5-[4(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate + TX, Methyl (Z)-3-methoxy-2-[2-methyl-5-(4propyltriazol-2-yl)phenoxy]prop-2-enoate + TX, (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3methoxy-prop-2-enoate + TX, Methyl (Z)-3-methoxy-2-[2methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate + TX, (Z)-3-methoxy-2-[2-methyl-5-[3(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate methyl + TX (these compounds can be prepared from the methods described in WO2020 / 079111), (Z)-2-(5-cyclohexyl-2-methylphenoxy)-3-methoxyprop-2-enoate methyl + TX, (Z)-2-(5-cyclopentyl-2-methylphenoxy)-3-methoxyprop-2-enoate methyl + TX (these compounds can be prepared from the methods described in WO2020 / 193387), 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3pyridyl]oxy]benzonitrile + TX,4-[[6-[2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(5-sulfanyl1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxi]benzonitrila + TX, 4-[[6-[2-(2,4-difluorofenil)-1,1-difluoro-2hidroxi-3-(5-tioxo-4H-1,2,4-triazol-1-yl)propyl]-3pyridyl]oxi]benzonitrila + TX, trinexapac + TX, coumoxistrobina + TX, zhongshengmicina + TX, thiodiazol cúprico + TX, thiazol de zinco + TX, amectotractina + TX, iprodione + TX. seboctylamine + TX; N'-[5-bromo-2-metil6-[(1S)-1-metil-2-propoxy-ethoxi]-3-pyridyl]-N-etil-Nmetil-formamidina + TX, N'-[5-bromo-2-metil-6-[(1R)-1metil-2-propoxy-ethoxi]-3-pyridyl]-N-etil-N-metilPetição 870260073221, de 23 / 07 / 2026, pág. 201 / 259, 196 / 240 formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-Nisopropyl-N-methyl-formamidine + TX (these compounds can be prepared from the methods described in WO2015 / 155075); N'-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX (this compound can be prepared from the methods described in IPCOM000249876D); N-isopropyl-N'-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)phenyl]-N-methyl-formamidine + TX, N'-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxyethyl)-5-methoxy-2-methylphenyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared from the methods described in WO2018 / 228896);N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]N-methyl-formamidine + TX, N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)tetrahydrofuran-2-yl]phenyl]-N-methyl-formamidine + TX (these compounds can be prepared from the methods described in WO2019 / 110427); N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3enyl]-8-fluoro-quinoline-3-carboxamide + TX,[N-[(1S)-1benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline3-carboxamide + TX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1methyl-propyl]-8-fluoro-quinoline-3-carboxamide + TX, N[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8fluoro-quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro; Petition 870260073221, dated 07 / 23 / 2026, pages 202 / 259 197 / 240 quinoline-3-carboxamide + TX, 8-fluoro-N-[(1R)-1-[(3fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3carboxamide + TX, 8-fluoro-N-[(1S)-1-[(3fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3carboxamide + TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + TX, N-((1R)-1-benzyl-3-chloro-1-methyl-but3-enyl)-8-fluoro-quinoline-3-carboxamide + TX, N-((1S)1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoroquinoline-3-carboxamide + TX (these compounds can be prepared from the methods described in WO2017 / 153380);1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline + TX, 1(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,6trifluoro-3,3-dimethyl-isoquinoline + TX, 4,4-difluoro3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3yl)isoquinoline + TX, 4,4-difluoro-3,3-dimethyl-1-(7methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline + TX, 1(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4difluoro-3,3-dimethyl-isoquinoline + TX (est. compounds can be prepared using the methods described in WO2017 / 025510); 1-(4,5-dimetilbenzimidazol-1-yl)-4,4,5trifluoro-3,3-dimetil-isoquinolina + TX, 1-(4,5dimetilbenzimidazol-1-yl)-4,4-difluoro-3,3-dimetilisoquinolina + TX, 6-cloro-4,4-difluoro-3,3-dimetil-1(4-metilbenzimidazol-1-yl)isoquinolina + TX, 4,4difluoro-1-(5-fluoro-4-metil-benzimidazol-1-yl)-3,3dimetil-isoquinolina + TX, 3-(4,4-difluoro-3,3-dimetil1-isoquinolil)-7,8-di-hidro-6Hciclopenta[e]benzimidazol + TX (estes compostas podem; Petition 870260073221, dated 07 / 23 / 2026, pp. 203 / 259 198 / 240 be prepared from the methods described in WO2016 / 156085); N-methoxy-N-[[4-[5-(trifluoromethyl)1,2,4-oxadiazol-3yl]phenyl]methyl]cyclopropanecarboxamide + TX, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]propanamide + TX, N-ethyl-2-methyl-N-[[4[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]propanamide + TX, 1-methoxy-3-methyl-1[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]urea + TX, 1,3-dimethoxy-1-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + TX, 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + TX, N-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]propanamide + TX, 4,4-dimethyl-2-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]isoxazolidin-3-one + TX, 5,5-dimethyl-2[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]isoxazolidin-3-one + TX, 1-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]pyrazole-4-carboxylate of ethyl + TX, N,Ndimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]phenyl]methyl]pyrazole-4-carboxylate of ethyl + TX,4-oxadiazol-3yl]phenyl]methyl]-1,2,4-triazol-3-amine + TX. The compounds in this paragraph can be prepared from the methods described in WO 2017 / 055473, WO 2017 / 055469, WO 2017 / 093348 and WO 2017 / 118689; 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol + TX (this compound can be prepared from the methods described in WO 2017 / 029179); 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol + TX (this compound can be, Petition 870260073221, dated 07 / 23 / 2026, pp. 204 / 259 199 / 240 prepared from the methods described in WO 2017 / 029179); 3-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]imidazole-4-carbonitrile + TX (this compound can be prepared from the methods described in WO 2016 / 156290); 3-[2-(1-chlorocyclopropyl)3-(3-chloro-2-fluorophenyl)-2-hydroxypropyl]imidazole-4-carbonitrile + TX (this compound can be prepared from the methods described in WO 2016 / 156290); 2-amino-6-methylpyridine-3-carboxylate of (4-phenoxyphenyl)methyl + TX (this compound can be prepared from the methods described in WO 2014 / 00694 5); 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-C:5,6C']dipyrrole-1,3,5,7(2H,6H)-tetrone + TX (this compound can be prepared from the methods described in WO 2011 / 138281); N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzenecarbothioamide + TX; N-methyl-4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide + TX;(Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxy-imino-N,3-dimethyl-pent-3-enamide + TX (this compound can be prepared from the methods described in WO 2018 / 153707); N'-(2-chloro-5-methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine + TX; N'-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N-methylformamidine + TX (this compound can be prepared from the methods described in WO 2016 / 202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX (this compound can be prepared from the methods described in WO 2014 / 095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone + TX, (3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl) Petition 870260073221, dated 23 / 07 / 2026, page 205 / 259; 200 / 240 1,2,4-oxadiazol-3-yl]phenyl]methanone + TX (these compounds can be prepared using the methods described in WO 2017 / 220485); 2-oxo-N-propyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX (this compound can be prepared using the methods described in WO 2018 / 065414); 1-[[5-[5-(trifluoromethyl)1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]pyrazole-4-carboxylate ethyl + TX (this compound can be prepared using the methods described in WO 2018 / 158365); 2,2-difluoro-N-methyl-2-[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX, N-[(E)-methoxy-iminomethyl]-4-[5-(trifluoromethyl)1,2,4-oxadiazol-3-yl]benzamide + TX, N-[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3yl]benzamide + TX, N-[N-methoxy-C-methyl-carbonimidoyl]4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide + TX (these compounds can be prepared from the methods described in WO 2018 / 202428); microbes including: Acinetobacter lwoffii + TX, Acremonium alternatum + TX, Acremonium cephalosporium + TX, Acremonium diospyri + TX, Acremonium obclavatum + TX, Adoxophyes orana granulovirus (AdoxGV) (Capex®) + TX, Agrobacterium radiobacter strain K84 (GalltrolA®) + TX, Alternaria alternate + TX, Alternaria cassia + TX, Alternaria destruens (Smolder®) + TX, Ampelomyces quisqualis (AQ10®) + TX, Aspergillus flavus AF36 (AF36®) + TX, Aspergillus flavus NRRL 21882 (Aflaguard®) + TX, Aspergillus spp. + TX, Aureobasidium pullulans + TX, Azospirillum (MicroAZ®, TAZO B®) + TX, Azotobacter + TX, Azotobacter chroocuccum (Azotomeal®) + TX, cysts of Azotobacter (Bionatural Blooming Blossoms®) + TX, Petition 870260073221, dated 23 / 07 / 2026, p. 206 / 259 201 / 240 Bacillus amyloliquefaciens + TX, Bacillus cereus + TX, Bacillus chitinosporus strain CM-1 + TX, Bacillus chitinosporus strain AQ746 + TX, Bacillus licheniformis strain HB-2 (e.g., Biostart™, formerly Rhizoboost®) + TX, Bacillus licheniformis strain 3086 (EcoGuard®, Green Releaf®) + TX, Bacillus circulans + TX, Bacillus firmus (BioSafe®, BioNem-WP®, VOTiVO®) + TX, Bacillus firmus strain I-1582 + TX, Bacillus macerans + TX, Bacillus marismortui + TX, Bacillus megaterium + TX, Bacillus mycoides strain AQ726 + TX, Bacillus papillae (Milky Spore Powder®) + TX, Bacillus pumilus spp. + TX, strain GB34 of Bacillus pumilus (Yield Shield®) + TX, strain AQ717 of Bacillus pumilus + TX, strain QST 2808 of Bacillus pumilus (Sonata®, Ballad Plus®) + TX, Bacillus spahericus (VectoLex®) + TX, Bacillus spp. + TX, strain AQ175 of Bacillus spp. + TX, strain AQ177 of Bacillus spp. + TX, strain AQ178 of Bacillus spp.+ TX, strain QST 713 of Bacillus subtilis (CEASE®, Serenade®, Rhapsody®) + TX, strain QST 714 of Bacillus subtilis (JAZZ®) + TX, strain AQ153 of Bacillus subtilis + TX, strain. AQ743 of Bacillus subtilis + TX, strain QST3002 of Bacillus subtilis + TX, strain QST3004 of Bacillus subtilis + TX, strain FZB24 of Bacillus subtilis var. amyloliquefaciens (Taegro®, Rhizopro®) + TX, Cry2Ae of Bacillus thuringiensis + TX, Cry1Ab of Bacillus thuringiensis + TX, Bacillus thuringiensis aizawai GC 91 (Agree®) + TX, Bacillus thuringiensis israelensis (BMP123®, Aquabac®, VectoBac®) + TX, Bacillus thuringiensis kurstaki (Javelin®, Deliver®, CryMax®, Bonide®, Scutella WP®, Turilav WP®, Astuto®, Dipel WP®, Biobit®, Foray®) + TX, Bacillus thuringiensis kurstaki BMP 123 (Baritone®) + Petition 870260073221, dated 23 / 07 / 2026, p. 207 / 259 202 / 240 TX, Bacillus thuringiensis kurstaki HD-1 (BioprotecCAF / 3P®) + TX, Bacillus thuringiensis strain BD#32 + TX, Bacillus thuringiensis strain AQ52 + TX, Bacillus thuringiensis var. aizawai (XenTari®, DiPel®) + TX, Bacteria spp. (GROWMEND®, GROWSWEET®X, Shootup®)+TX, Clavipacter michiganensis bacteriophage (AgriPhage®)+TX, Bakflor®+TX, Beauveria bassiana (Beaugenic®, Brocaril WP®)+TX, Beauveria bassiana GHA (Mycotrol ES®, Mycotrol O®, BotaniGuard®)+ TX, Beauveria brongniarti (Engerlingspilz®, Schweizer Beauveria®, Melocont®) + TX, Beauveria spp. + TX, Botrytis cineria + TX, Bradyrhizobium japonicum (TerraMax®) + TX, Brevibacillus brevis + TX, Bacillus thuringiensis tenebrionis (Novodor®) + TX, BtBooster + TX, Burkholderia cepacia (Deny®, Intercept®, Blue Circle®) + TX, Burkholderia gladii + TX, Burkholderia gladioli + TX, Burkholderia spp.+ TX, Canadian thistle fungus (CBH Canadian Bioherbicide®) + TX, Candida butyri + TX, Candida famata + TX, Candida fructus + TX, Candida glabrata + TX, Candida guilliermondii + TX, Candida melibiosica + TX, Candida oleophila strain O + TX, Candida parapsilosis + TX, Candida pelliculosa + TX, Candida pulcherrima + TX, Candida reukaufii + TX, Candida saitoana (Bio-Coat®, Biocure®) + TX, Candida sake + TX, Candida spp. + TX, Candida tenius + TX, Cedecea dravisae + TX, Cellulomonas flavigena + TX, Chaetomium cochliodes (Nova-Cide®) + TX, Chaetomium globosum (Nova-Cide®) + TX, Chromobacterium subtsugae strain PRAA4-1T (Grandevo®) + TX, Cladosporium cladosporioides + TX, Cladosporium oxysporum + TX, Cladosporium chlorocephalum + TX, Cladosporium spp. + TX, Cladosporium tenuissimum. Petition 870260073221, dated 23 / 07 / 2026, p. 208 / 259 203 / 240 + TX, Clonostachys rosea (EndoFine®) + TX, Colletotrichum acutatum + TX, Coniothyrium minitans (Cotans WG®) + TX, Coniothyrium spp. + TX, Cryptococcus albidus (YIELDPLUS®) + TX, Cryptococcus humicola + TX, Cryptococcus infirmo-miniatus + TX, Cryptococcus laurentii + TX, Cryptphlebia leucotreta granulovirus (Cryptex®) + TX, Cupriavidus campinensis + TX, Cydia pomonella granulovirus (CYD-X®) + TX, Cydia pomonella granulovirus (Madex®, Madex® Plus, Madex® Max, Carpovirusine Evo2®) + TX, Cylindrobasidium laeve (Stumpout®) + TX, Cylindrocladium + TX, Debaryomyces hansenii + TX, Drechslera hawaiinensis + TX, Enterobacter cloacae + TX, Enterobacteriaceae + TX, Entomophtora virulenta (Vektor®) + TX, Epicoccum nigrum + TX, Epicoccum purpurascens + TX, Epicoccum spp. + TX, Filobasidium floriforme + TX, Fusarium acuminatum + TX, Fusarium chlamydosporum + TX, Fusarium oxysporum (Fusaclean®, Biofox C®) + TX, Fusarium proliferatum + TX, Fusarium spp.+ TX, Galactomyces geotrichum + TX, Gliocladium catenulatum (Primastop®, Prestop®) + TX, Gliocladium roseum + TX, Gliocladium spp. (SoilGard®) + TX, Gliocladium virens (Soilgard®) + TX, Granulovirus (Granupom®) + TX, Halobacillus halophilus + TX, Halobacillus litoralis + TX, Halobacillus trueperi + TX, Halomonas spp. + TX, Halomonas subglaciescola + TX, Halovibrio variabilis + TX, Hanseniaspora uvarum + TX, Helicoverpa armigera nucleopolyhedrovirus (Helicovex®) + TX, Helicoverpa zea nuclear polyhedrosis virus (Gemstar®) + TX, Isoflavone - formononetin (Myconate®) + TX, Kloeckera apiculata + TX, Kloeckera spp. + TX, Lagenidium giganteum (Laginex®) + TX, Lecanicillium. Petition 870260073221, dated 23 / 07 / 2026, p. 209 / 259 204 / 240 longisporum (Vertiblast®) + TX, Lecanicillium muscarium (Vertikil®) + TX, vírus da nucleopoliedrose de Lymantria dispar (Disparvirus®) + TX, Marinococcus halophilus + TX, Meira geulakonigii + TX, Metarhizium anisopliae (Met52®) + TX, Metarhizium anisopliae (Destruxin WP®) + TX, Metschnikowia fruticola (Shemer®) + TX, Metschnikowia pulcherrima + TX, Microdochium dimerum (Antibot®) + TX, Micromonospora coerulea + TX, Microsphaeropsis ochracea + TX, Muscodor albus 620 (Muscudor®) + TX, cepa A3-5 de Muscodor roseus + TX, Mycorrhizae spp. (AMykor®, Root Maximizer®) + TX, cepa AARC-0255 de Myrothecium verrucaria (DiTera®) + TX, BROS PLUS® + TX, cepa D97 de Ophiostoma piliferum (Sylvanex®) + TX, Paecilomyces farinosus + TX, Paecilomyces fumosoroseus (PFR-97®, PreFeRal®) + TX, Paecilomyces linacinus (Biostat WP®) + TX, cepa 251 de Paecilomyces lilacinus (MeloCon WG®) + TX, Paenibacillus polymyxa + TX, Pantoea agglomerans (BlightBan C9-1®) + TX, Pantoea spp. + TX, Pasteuria spp.(Econem®) + TX, Pasteuria nishizawae + TX, Penicillium aurantiogriseum + TX, Penicillium billai (Jumpstart®, TagTeam®) + TX, Penicillium brevicompactum + TX, Penicillium frequentans + TX, Penicillium griseofulvum + TX, Penicillium purpurogenum + TX, Penicillium spp. + TX, Penicillium viridicatum + TX, Phlebiopsis gigantean (Rotstop®) + TX, phosphate solubilizing bacteria (Phosphomeal®) + TX, Phytophthora cryptogea + TX, Phytophthora palmivora (Devine®) + TX, Pichia anomala + TX, Pichia guilermondii + TX, Pichia membranaefaciens + TX, Pichia onychis + TX, Pichia stipites + TX, Pseudomonas aeruginosa + TX, Pseudomonas aureofasciens (Spot-Less Biofungicide®) +. Petition 870260073221, dated 23 / 07 / 2026, p. 210 / 259 205 / 240 TX, Pseudomonas cepacia + TX, Pseudomonas chlororaphis (AtEze®) + TX, Pseudomonas corrugate + TX, Pseudomonas fluorescens strain A506 (BlightBan A506®) + TX, Pseudomonas putida + TX, Pseudomonas reactans + TX, Pseudomonas spp. + TX, Pseudomonas syringae (Bio-Save®) + TX, Pseudomonas viridiflava + TX, Pseudomons fluorescens (Zequanox®) + TX, Pseudozyma flocculosa strain PF-A22 UL (Sporodex L®) + TX, Puccinia canaliculata + TX, Puccinia thlaspeos (Wood Warrior®) + TX, Pythium paroecandrum + TX, Pythium oligandrum (Polygandron®, Polyversum®) + TX, Pythium periplocum + TX, Rhanella aquatilis + TX, Rhanella spp. + TX, Rhizobia (Dormal®, Vault®) + TX, Rhizoctonia + TX, strain AQ719 of Rhodococcus globerulus + TX, Rhodosporidium diobovatum + TX, Rhodosporidium toruloides + TX, Rhodotorula spp.+ TX, Rhodotorula glutinis + TX, Rhodotorula graminis + TX, Rhodotorula mucilagnosa + TX, Rhodotorula rubra + TX, Saccharomyces cerevisiae + TX, Salinococcus roseus + TX, Sclerotinia minor + TX, Sclerotinia minor (SARRITOR®) + TX, Scytalidium spp. + TX, Scytalidium uredinicola + TX, vírus da poliedrose nuclear de Spodoptera exigua (Spod-X®, Spexit®) + TX, Serratia marcescens + TX, Serratia plymuthica + TX, Serratia spp. + TX, Sordaria fimicola + TX, nucleopoliedrovírus de Spodoptera littoralis (Littovir®) + TX, Sporobolomyces roseus + TX, Stenotrophomonas maltophilia + TX, Streptomyces ahygroscopicus + TX, Streptomyces albaduncus + TX, Streptomyces exfoliates + TX, Streptomyces galbus + TX, Streptomyces griseoplanus + TX, Streptomyces griseoviridis (Mycostop®) + TX, Streptomyces lydicus (Actinovate®) + TX, Streptomyces. Petição 870260073221, de 23 / 07 / 2026, pág. 211 / 259 206 / 240 lydicus WYEC-108 (ActinoGrow®) + TX, Streptomyces violaceus + TX, Tilletiopsis minor + TX, Tilletiopsis spp. + TX, Trichoderma asperellum (T34 Biocontrol®) + TX, Trichoderma gamsii (Tenet®) + TX, Trichoderma atroviride (Plantmate®) + TX, Trichoderma hamatum TH 382 + TX, Trichoderma harzianum rifai (Mycostar®) + TX, Trichoderma harzianum T-22 (Trianum-P®, PlantShield HC®, RootShield®, Trianum-G®) + TX, Trichoderma harzianum T39 (Trichodex®) + TX, Trichoderma inhamatum + TX, Trichoderma koningii + TX, Trichoderma spp. LC 52 (Sentinel®) + TX, Trichoderma lignorum + TX, Trichoderma longibrachiatum + TX, Trichoderma polysporum (Binab T®) + TX, Trichoderma taxi + TX, Trichoderma virens + TX, Trichoderma virens (formerly Gliocladium virens GL21) (SoilGuard®) + TX, Trichoderma viride + TX, Trichoderma viride strain ICC 080 (Remedier®) + TX, Trichosporon pullulans + TX, Trichosporon spp. + TX, Trichothecium spp.+ TX, Trichothecium roseum + TX, Typhula phacorrhiza strain 94670 + TX, Typhula phacorrhiza strain 94671 + TX, Ulocladium atrum + TX, Ulocladium oudemansii (Botry-Zen®) + TX, Ustilago maydis + TX, various bacteria and supplemental micronutrients (Natural II®) + TX, various fungi (Millennium Microbes®) + TX, Verticillium chlamydosporium + TX, Verticillium lecanii (Mycotal®, Vertalec®) + TX, Vip3Aa20 (VIPtera®) + TX, Virgibaclillus marismortui + TX, Xanthomonas campestris pv. Poae (Camperico®) + TX, Xenorhabdus bovienii + TX and Xenorhabdus nematophilus + TX;. Plant extracts including: pine oil (Retenol®) + TX, azadirachtin (Plasma Neem Oil®, AzaGuard®, MeemAzal®, Molt-X®) + TX, Botanical IGR (Neemazad®, Petition 870260073221, dated 07 / 23 / 2026, pp. 212 / 259 207 / 240 Neemix®) + TX, canola oil (Lilly Miller Vegol®) + TX, Chenopodium ambrosioides near ambrosioides (Requiem®) + TX, Chrysanthemum extract (Crisant®) + TX, bitterberry oil extract (Trilogy®) + TX, Labiatae essential oils (Botania®) + TX, clove, rosemary, peppermint and thyme oil extracts (Garden insect killer®) + TX, Glycine betaine (Greenstim®) + TX, garlic, lemongrass oil (GreenMatch®) + TX, bitterberry oil + TX, Nepeta cataria (catnip oil) + TX, Nepeta catarina, nicotine, oregano oil (MossBuster®) + TX, oil of Pedaliaceae (Nematon®) + TX, pyrethrum + TX, Quillaja saponaria (NemaQ®) + TX, Reynoutria sachalinensis (Regalia®, Sakalia®) + TX, rotenone (Eco Roten®) + TX, Rutaceae plant extract (Soleo®) + TX, soybean oil (Ortho ecosense®) + TX, tea tree oil (Timorex Gold®) + TX, thyme oil + TX, AGNIQUE® MMF + TX, BugOil® + TX, blend of rosemary, sesame, peppermint extracts,Thyme and Cinnamon (EF 300®) + TX, blend of clove, rosemary and peppermint extracts (EF 400®) + TX, blend of clove, peppermint, garlic and mint oil (Soil Shot®) + TX, kaolin (Screen®) + TX, brown algae storage glucam (Laminarin®) + TX; Pheromones including: Blackheaded Fireworm Pheromone (3M Sprayable Blackheaded Fireworm Pheromone®) + TX, Apple Moth Pheromone (Paramount-(CM) / Isomate C-Plus® dispenser) + TX, Grape Moth Pheromone (3M MEC-GBM Sprayable Pheromone®) + TX, Leaf Roller Pheromone (3M MEC-LR Sprayable Pheromone®) + TX, Muscamona (Snip7 Fly Bait®, Starbar Premium Fly Bait®) + TX, Oriental Fruit Moth Pheromone (3M Petition 870260073221, dated 07 / 23 / 2026, pp. 213 / 259 208 / 240 Oriental Fruit Moth Sprayable Pheromone®) + TX, Peach Borer Pheromone (Isomate-P®) + TX, Tomato Moth Pheromone (3M Sprayable Pheromone®) + TX, Entostat Powder (Palm Extract) (Exosex CM®) + TX, (3E,8Z,11Z)-3,8,11-Tetradecatrienyl Acetate + TX, (7Z,11Z,13E)-7,11,13-Hexadecatrienal + TX, (E,Z)-7,9-Dodecadien-1-yl Acetate + TX, 2-Methyl-1-butanol + TX, Calcium Acetate + TX, Scenturion® + TX, Biolure® + TX, Check-Mate® + TX, Senecioate Lavandulilla + TX; Macrobians including: Aphelinus abdominalis + TX, Aphidius ervi (Aphelinus-System®) + TX, Acerophagus papaya + TX, Adalia bipunctata (Adalia-System®) + TX, Adalia bipunctata (Adaline®) + TX, Adalia bipunctata (Aphidalia®) + TX, Ageniaspis citricola + TX, Ageniaspis fuscicollis + TX, Amblyseius andersoni (Anderline®, Andersoni-System®) + TX, Amblyseius californicus (Amblyline®, Spical®) + TX, Amblyseius cucumeris (Thripex®, Bugline cucumeris®) + TX, Amblyseius fallacis (Fallacis®) + TX, Amblyseius swirskii (Bugline swirskii®, Swirskii-Mite®) + TX, Amblyseius womersleyi (WomerMite®) + TX, Amitus hesperidum + TX, Anagrus atomus + TX, Anagyrus fusciventris + TX, Anagyrus kamali + TX, Anagyrus loecki + TX, Anagyrus pseudococci (Citripar®) + TX, Anicetus beneficis + TX, Anisopteromalus calandrae + TX, Anthocoris nemoralis (Anthocoris-System®) + TX, Aphelinus abdominalis (Apheline®, Aphiline®) + TX, Aphelinus asychis + TX, Aphidius colemani (Aphipar®) + TX, Aphidius ervi (Ervipar®) + TX,Aphidius gifuensis + TX, Aphidius matricariae (Aphipar-M®) + TX, Aphidoletes aphidimyza (Aphidend®) + TX, Aphidoletes aphidimyza (Aphidoline®) + TX, Aphytis lingnanensis + TX, Aphytis, Petition 870260073221, dated 23 / 07 / 2026, p. 214 / 259 209 / 240 melinus + TX, Aprostocetus hagenowii + TX, Atheta coriaria (Staphyline®) + TX, Bombus spp. + TX, Bombus terrestris (Natupol Beehive®) + TX, Bombus terrestris (Beeline®, Tripol®) + TX, Cephalonomia stephanoderis + TX, Chilocorus nigritus + TX, Chrysoperla carnea (Chrysoline®) + TX, Chrysoperla carnea (Chrysopa®) + TX, Chrysoperla rufilabris + TX, Cirrospilus ingenuus + TX, Cirrospilus quadristriatus + TX, Citrostichus phyllocnistoides + TX, Closterocerus chamaeleon + TX, Closterocerus spp.+ TX, Coccidoxenoides perminutus (Planopar®) + TX, Coccophagus cowperi + TX, Coccophagus lycimnia + TX, Cotesia flavipes + TX, Cotesia plutellae + TX, Cryptolaemus montrouzieri (Cryptobug®, Cryptoline®) + TX, Cybocephalus nipponicus + TX, Dacnusa sibirica + TX, Dacnusa sibirica (Minusa®) + TX, Diglyphus isaea (Diminex®) + TX, Delphastus catalinae (Delphastus®) + TX, Delphastus pusillus + TX, Diachasmimorpha krausii + TX, Diachasmimorpha longicaudata + TX, Diaparsis jucunda + TX, Diaphorencyrtus aligarhensis + TX, Diglyphus isaea + TX, Diglyphus isaea (Miglyphus®, Digline®) + TX, Dacnusa sibirica (DacDigline®, Minex®) + TX, Diversinervus spp.+ TX, Encarsia citrina + TX, Encarsia formosa (Encarsia max®, Encarline®, En-Strip®) + TX, Eretmocerus eremicus (Enermix®) + TX, Encarsia guadeloupae + TX, Encarsia haitiensis + TX, Episyrphus balteatus (Syrphidend®) + TX, Eretmoceris siphonini + TX, Eretmocerus californicus + TX, Eretmocerus eremicus (Ercal®, Eretline e®) + TX, Eretmocerus eremicus (Bemimix®) + TX, Eretmocerus hayati + TX, Eretmocerus mundus (Bemipar®, Eretline m®) + TX, Eretmocerus siphonini + TX, Exochomus quadripustulatus. Petition 870260073221, dated 23 / 07 / 2026, p. 215 / 259 210 / 240 + TX, Feltiella acarisuga (Spidend®) + TX, Feltiella acarisuga (Feltiline®) + TX, Fopius arisanus + TX, Fopius ceratitivorus + TX, Formononetina (Wirless Beehome®) + TX, Franklinothrips vespiformis (Vespop®) + TX, Galendromus occidentalis + TX, Goniozus legneri + TX, Habrobracon hebetor + TX, Harmonia axyridis (HarmoBeetle®) + TX, Heterorhabditis spp. (Lawn Patrol®) + TX, Heterorhabditis bacteriophora (NemaShield HB®, Nemaseek®, Terranem-Nam®, Terranem®, Larvanem®, BGreen®, NemAttack®, Nematop®) + TX, Heterorhabditis megidis (Nemasys H®, BioNem H®, Exhibitline hm®, Larvanem-M®) + TX, Hippodamia convergens + TX, Hypoaspis aculeifer (Aculeifer-System®, Entomite-A®) + TX, Hypoaspis miles (Hypoline m®, Entomite-M®) + TX, Lbalia leucospoides + TX, Lecanoideus floccissimus + TX, Lemophagus errabundus + TX, Leptomastidea abnormis + TX, Leptomastix dactylopii (Leptopar®) + TX, Leptomastix epona + TX, Lindorus lophanthae + TX, Lipolexis oregmae + TX, Lucilia caesar (Natufly®) + TX,Lysiphlebus testaceipes + TX, Macrolophus caliginosus (Mirical-N®, Macroline c®, Mirical®) + TX, Mesoseiulus longipes + TX, Metaphycus flavus + TX, Metaphycus lounsburyi + TX, Micromus angulatus (Milacewing®) + TX, Microterys flavus + TX, Muscidifurax raptorellus and Spalangia cameroni (Biopar®) ...

Claims

1. Method for combating and controlling an animal pest, characterized in that it is for (i) reducing damage to a plant, comprising applying to the pest, to a locus of the pest or to a plant susceptible to attack by the pest an effective amount of any of the compounds of formula I or formula II; or (ii) protecting plant propagation material, comprising treating the propagation material, or the location where the propagation material is planted, with an effective amount of any of the compounds of formula I or formula II; wherein the compounds of formula I and formula II are where X, regardless of formula I or II, is O, S, SO, SO2, SO(NH) or CH2;R1, R2, R3 and R4, regardless of formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; R5, R6 and R7, regardless of formula I or II, are each independently selected from hydrogen, halogen, Petition 870260073221, dated 23 / 07 / 2026, page. 247 / 259 2 / 10 cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkyl, C1-C4-alkylSulfinyl, C1-C4-haloalkylsulfinyl, C1-C4alkylsulfonyl and C1-C4haloalkylsulfonyl; Y is hydrogen, C1-C6-alkyl, C3-C6-alkenyl, C3C6-alkynyl, C3-C6-cycloalkyl-C1-C2-alkyl, aryl-C1-C2-alkyl or C1-C4-alkoxy-C1-C2-alkyl;J is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl or C1-C2 alkyl substituted by a C3-C6 cycloalkyl, aryl, C5-C10 heteroaryl or C4-C10 heterocyclyl, whose C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, independently of each other, may be substituted by 1 to 3 substituents, independently selected from Ra, whose C3-C6 cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl, heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rb; or J is aryl, heteroaryl-C5-C10 or heterocyclyl-C4-C10, wherein the aryl, heteroaryl-C5-C10 and heterocyclyl-C4-C10 groups may independently be substituted by 1 to 4 substituents, independently selected from Rb;or J is C1-C6-C(O) alkyl, C3-C6-C(O) cycloalkyl, C(O) aryl, C5-C10-C(O) heteroaryl or C4-C10-C(O) heterocyclyl, wherein the alkyl may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rd;or J is C1-C6-S(O)2 alkyl, C3-C6-S(O)2 cycloalkyl, S(O)2 aryl, C5-C10-S(O)2 heteroaryl or C4-C10-S(O)2 heterocyclyl, wherein the alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Re;or J is C1-C6 alkoxy, C3-C6 cycloalkyl-C1-C2 alkoxy, C1-C2 aryl alkoxy, C5-C10 heteroaryl-C1-C2 alkoxy or C4-C10 heterocyclyl-C1-C2 alkoxy, wherein the alkoxy may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rf;T is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C6 cycloalkyl, C1-C2 alkyl, C1-C2 aryl alkyl or C5-C10 heteroaryl, C1-C2 alkyl, whose alkyl, C3-C6 alkenyl, C3-C6 alkynyl may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl may independently be substituted by 1 to 4 substituents, independently selected from Rg; Petition 870260073221, dated 23 / 07 / 2026, p. 249 / 259 4 / 10 Ra, regardless of formula I or II, regardless of the substituent to which it is attached, is selected from halogen, cyano and C1-C3 alkoxy;Rb, Rd, Re, Rf and Rg, regardless of formula I or II, and regardless of the substituent to which it is attached, is selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C4-C10 heterocyclyl (whose phenyl, phenoxy, heteroaryl and heterocyclyl, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl); Rc, regardless of whether it is formula I or II, is selected from halogen, cyano, C1-C3 alkyl, and C1-C3 alkoxy; or an agrochemically acceptable salt, stereoisomer, tautomer, and / or N-oxide of the compound of formula I or formula II.

2. Compound of formula II or of formula II-I, II II-I characterized in that Petition 870260073221, dated 07 / 23 / 2026, page 250 / 259 5 / 10 X, with respect to formula I, is O, S, SO, SO2 or SO(NH); X, with respect to formula II, is O, S, SO, SO2, SO(NH) or CH2; R1, R2, R3 and R4, regardless of whether they belong to formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl; R5, R6 and R7, regardless of whether they are formula I or II, are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl and C1-C4 haloalkylsulfonyl;Y is hydrogen, C1-C6-alkyl, C3-C6-alkenyl, C3C6-alkynyl, C3-C6-cycloalkyl-C1-C2-alkyl, aryl-C1-C2-alkyl or C1-C4-alkoxy-C1-C2-alkyl; J is C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl or C1-C2 alkyl substituted by a C3-C6 cycloalkyl, aryl, C5-C10 heteroaryl or C4-C10 heterocyclyl, whose C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, independently of each other, may be substituted by 1 to 3 substituents, independently selected from Ra, whose C3-C6 cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl, heteroaryl and C4-C10 heterocyclyl may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rb;or Petition 870260073221, dated 07 / 23 / 2026, p. 251 / 259 6 / 10 J is aryl, heteroaryl-C5-C10 or heterocyclyl-C4-C10, whose aryl, heteroaryl-C5-C10 and heterocyclyl-C4-C10 can, independently of each other, be replaced by 1 to 4 substituents, independently selected from Rb; or J is C1-Ce-C(O) alkyl, C3-C6-C(O) cycloalkyl, C(O) aryl, C5-C10-C(O) heteroaryl or C4-C10-C(O) heterocyclyl, wherein the alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rd;or J is C1-C6-S(O)2 alkyl, C3-C6-S(O)2 cycloalkyl, S(O)2 aryl, C5-C10-S(O)2 heteroaryl or C4-C10-S(O)2 heterocyclyl, wherein the alkyl group may be substituted by 1 to 3 substituents, independently selected from Ra, wherein the cycloalkyl group may be substituted by 1 to 3 substituents, independently selected from Rc, and wherein the aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl groups may, independently of each other, be substituted by 1 to 4 substituents, independently selected from Re;or J is C1-C6 alkoxy, C3-C6 cycloalkyl-C1-C2 alkoxy, C1-C2 aryl alkoxy, C5-C10 heteroaryl-C1-C2 alkoxy or C4-C10 heterocyclyl-C1-C2 alkoxy, whose alkoxy can be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl can be substituted by 1 to 3 substituents, independently selected from Rc, and whose aryl, C5-C10 heteroaryl and C4-C10 heterocyclyl Petition 870260073221, dated 23 / 07 / 2026, p. 252 / 259 7 / 10 can, independently of each other, be substituted by 1 to 4 substituents, independently selected from Rf;T is hydrogen, C1-C6 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C6 cycloalkyl, C1-C2 alkyl, C1-C2 aryl alkyl or C5-C10 heteroaryl, C1-C2 alkyl, whose alkyl, C3-C4 alkenyl and C3-C4 alkynyl may independently be substituted by 1 to 3 substituents, independently selected from Ra, whose cycloalkyl may be substituted by 1 to 3 substituents, independently selected from Rc, and whose C5-C10 aryl and heteroaryl may independently be substituted by 1 to 4 substituents, independently selected from Rg; Ra, regardless of formula I or II, regardless of the substituent to which it is attached, is selected from halogen, cyano and C1-C3 alkoxy;Rb, Rd, Re, Rf and Rg, regardless of formula I or II, and regardless of the substituent to which it is attached, is selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O), (C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C4 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C4-C10 heterocyclyl (whose phenyl, phenoxy, heteroaryl and heterocyclyl, independently of each other, may be substituted by 1-4 substituents, independently selected from halogen, cyano and C1-C3 alkyl); Rc, regardless of whether it is formula I or II, is selected from halogen, cyano, C1-C3 alkyl, and C1-C3 alkoxy;with the condition that, when X is CH2 in formula II, T is not hydrogen, C1-C4 alkyl, 2-fluoroethyl, 2-methyl-4-pyrimidinyl)methyl, 2-(methylsulfonyl)phenyl]methyl, 2,6-di(tert-butyl)-4-methylphenyl, 1,4-dihydro-6-methyl-4-oxo-3-pyridazinyl)methyl, 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl or tetrahydro-4,4-dimethyl-2-oxo-3-furanyl; or, when X is O in formula II, T is not hydrogen or C1-C2 alkyl; or an agronomically acceptable salt, stereoisomer, tautomer and / or N-oxide of the compound of formula II or of formula II-I.; 3. Method according to claim 1, or compound according to claim 2, characterized in that J is hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C2 aryl alkoxy, C1-C3-S(O)2 alkyl, C3-C4-S(O)2 cycloalkyl, C3-C4 cycloalkyl-C1-C2 alkyl, C5-C10 heteroaryl, C4-C10 heterocyclyl, C1-C2 aryl alkyl, C5-C10 aryl or heteroaryl, C1-C2 alkyl, wherein the alkyl may be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano and methoxy, wherein the alkoxy may be substituted by 1 to 3 substituents independently selected from chlorine, fluorine, cyano, methyl and methoxy, wherein Cycloalkyl groups may be substituted by 1 to 3 independently selected substituents of chlorine, fluorine, cyano, methyl and methoxy, and whose aryl, heteroaryl and heterocyclyl groups may independently be substituted by 1 to 4 independently selected substituents of halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, NH2C(O),(C1-C3 alkyl)N(H)C(O), NH2C(O)-C1-C3 alkoxy, (C1-C3 alkyl)SO2, benzyl, phenyl, phenoxy, C5-C6 heteroaryl and C5-C6 heterocyclyl (whose phenyl, phenoxy, heteroaryl or heterocyclyl groups, independently of each other, may be substituted by 14 substituents, independently selected from fluorine, chlorine, cyano and methyl). Petition 870260073221, dated 23 / 07 / 2026, p. 254 / 259 9 / 10, 4. A method according to any one of claims 1 or 3, or a compound according to any one of claims 2 or 3, characterized in that X is O or CH2, and Y, R1, R2, R3, R4, R5, R6 and R7 are each hydrogen.

5. A method according to any one of claims 1, 3 or 4, or the compound according to any one of claims 2, 3 or 4, characterized in that X is O.

6. A method according to any one of claims 1, 3 or 4, or a compound according to any one of claims 2, 3 or 4, characterized in that the compound is represented by formula Ia or Ib (when X is CH2, S, SO, SO, SO2 or SO(NH)); or represented by formula Ia or Icc (when X is O).

7. Composition, characterized in that it comprises a compound of formula I, II, III or II-I, as defined in any one of claims 1, 2, 3, 4, 5 or 6, one or more auxiliaries and diluents and, optionally, one or more other active ingredients.

8. Composition according to claim 7, characterized in that the compound is of formula I or II and is present as a mixture of compounds of formula Ia or Ib (when X is CH2, S, SO, SO, SO2 or SO(NH)); or represented by formula Iaa or Icc (when X is O).

9. A method for protecting plant propagation material from attack by insects, mites, nematodes or mollusks, characterized in that it comprises treating the propagation material, or the location where the propagation material is planted, with an effective amount of a compound, as defined in any one of claims 1, 2, 3, 4, 5 or 6, or a composition, as defined in any one of claims 7 or 8.

10. Plant propagation material, such as a seed, characterized in that it comprises, or is treated with, or adheres to, a compound, as defined in any one of claims 1, 2, 3, 4, 5 or 6, or a composition, as defined in any one of claims 7 or 8.