Flavor-modifying compositions and their uses

Abstract

Described herein are taste-modifying compositions and their use for reducing the unpleasant taste of a flavored product. The present disclosure further provides flavored products containing such taste- modifying compositions and one or more unpleasant tastants. The taste-modifying compositions described herein are suitable for use in food products, beverage products, or oral care products, such as toothpaste, dental gels, mouthwashes, mouth sprays, toothpaste, tablets and toothpaste powder.

Description

1 / 46 “FLAVORING MODIFIERS AND THEIR USES” CROSS-REFERENCE TO RELATED ORDERS

[0001] This application claims the benefit of priority under Provisional Application No. US 63 / 492,535, filed on March 28, 2023, and Application No. EU 23183763,4, filed on July 6, 2023, which are incorporated herein by reference in their entirety. DESCRIPTION FIELD

[0002] This description generally provides flavor-modifying compositions and their use in reducing the unpleasant taste of a flavored product. This description further provides flavored products that include such flavor-modifying compositions and an unpleasant taste agent. The flavor-modifying compositions described herein are suitable for use in food products, beverages, or oral care products, such as toothpaste, dental gels, mouthwashes, mouth sprays, toothpaste lozenges, powdered toothpaste, and the like. BACKGROUND OF THE DESCRIPTION

[0003] The taste system provides sensory information about the chemical composition of the external world. Taste transduction is one of the most sophisticated forms of chemically driven sensation in animals. Taste signaling is found throughout the animal kingdom, from simple metazoans to the most complex vertebrates. Mammals are believed to have five basic taste modalities: sweet, bitter, sour, salty, and umami.

[0004] Oral hygiene products often contain many active ingredients, such as antibacterial, whitening, and antisensitivity agents, which result in undesirable aftertastes in oral hygiene products. The inclusion of such active ingredients can lead to undesirable tastes that users find unpleasant. Limiting the concentration of such materials is a potential strategy to reduce the unpleasant taste. However, it may often be desirable to include such an ingredient in higher concentrations to achieve an enhanced effect.

[0005] Agents to mask undesirable aftertastes exist to meet this need. Petition 870250080417, dated 08 / 09 / 2025, page 11 / 61 2 / 46 to meet consumers' needs to mask undesirable notes resulting from these ingredients. However, some undesirable note masking agents are incompatible, i.e., insoluble, with flavoring oils commonly used in food products, beverages, or oral hygiene products. This prevents them from being combined into a single flavor delivery system that can be conveniently handled and incorporated into a final product.

[0006] Therefore, there is a continuing need for flavor delivery systems that contain undesirable note-masking agents and flavor oils that are easy to handle and stable (i.e., clear without precipitation) for extended periods of time at room temperature. SUMMARY OF DESCRIPTION

[0007] In a first aspect, the present description refers to a flavor-modifying composition comprising: a) one or more flavoring oils, b) one or more agents for masking undesirable grades, c) one or more non-polar surfactants, d) one or more polar surfactants, e) water, and f) one or more cosolvents miscible in water.

[0008] In a second aspect, the present description refers to a flavored product comprising the flavor-modifying composition described herein and an unpleasant taste agent.

[0009] In a third aspect, the present description refers to the use of the flavor-modifying composition described in this document to reduce the unpleasant taste of a flavored product. DETAILED DESCRIPTION

[0010] The following Detailed Description presents various aspects and modalities provided in this document. The description should be read from the perspective of a person with common skill in the relevant technique. Therefore, information that is well known to such craftspeople with common skills is not Petition 870250080417, dated 09 / 08 / 2025, p. 12 / 61 3 / 46 necessarily included. It would be evident to craftsmen of common skill that the various aspects and modalities provided in this document can be combined in any way without departing from the spirit of the description.

[0011] The following terms and phrases have the meanings indicated below, except as otherwise provided in this document. This description may employ other terms and phrases not expressly defined in this document. Such other terms and phrases have the meanings they would have within the context of this description to those with common skill in the art. In some cases, a term or expression may be defined in the singular or plural form. In such cases, it is understood that any term in the singular may include its counterpart in the plural and vice versa, unless expressly stated otherwise. Except as otherwise defined, all technical and scientific terms used in this document have the same meaning that is commonly understood by someone skilled in the art to which this descriptive report refers.

[0012] As used in this document, the terms a, an, the or a mean one or more or at least one, unless otherwise stated.

[0013] While compositions and methods are described in terms of comprising, containing, or including various components or steps, compositions and methods may also essentially consist of or consist of the various components, substances, and steps. As used herein, the term “essentially consisting of” shall be interpreted as including the listed components, substances, or steps and such additional components, substances, or steps that do not materially affect the basic and innovative properties of the composition or method. In some embodiments, a composition according to the embodiments of this description that essentially consists of the mentioned components or substances does not include any additional components or substances that alter the basic and innovative properties of the composition.

[0014] It should be understood that any numerical interval mentioned in this document is intended to include all subintervals contained therein. By Petition 870250080417, dated 09 / 08 / 2025, p. 13 / 61 4 / 46 For example, an interval from 1 to 10 is intended to include all subintervals between and that includes the mentioned minimum value of 1 and the mentioned maximum value of 10; that is, that has a minimum value equal to or greater than 1 and a maximum value equal to or less than 10. Due to the fact that the numerical ranges shown are continuous, they include all values ​​between the minimum and maximum values. Unless expressly stated otherwise, the various numerical intervals specified in this application are approximations.

[0015] As used in this document, and unless otherwise indicated, the term “about” or “approximately” means an acceptable error for a particular value as determined by someone with ordinary skill in the art, which depends in part on how the value is measured or determined. In certain embodiments, the term “about” or “approximately” means within 1, 2, 3, or 4 standard deviations. In certain embodiments, the term “about” or “approximately” means within 50%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.05% of a given value or range.

[0016] As used in this document, “optionally” means that the event subsequently described may or may not occur. In some embodiments, the optional event does not occur. In some other embodiments, the optional event occurs one or more times.

[0017] Throughout this description, various publications may be incorporated by reference. If the meaning of any language in such referenced publications conflicts with the meaning of the language in this description, the meaning of the language in this description shall prevail, unless otherwise indicated.

[0018] As used in this document, "or" should be given its broadest and most reasonable interpretation, and should not be limited to an either / or construction. Thus, the expression "comprising A or B" means that A may be present and not B, or that B is present and not A, or that A and B are both present. Furthermore, if A defines, for example, a class that may have multiple members, for example, A1 and A2, then one or more members of the class may be Petition 870250080417, dated 09 / 08 / 2025, p. 14 / 61 5 / 46 present simultaneously.

[0019] As used in this document, “for example,” “for instance,” “such as,” or “including” are intended to introduce examples that further clarify the more general subject matter. Unless expressly stated otherwise, such examples are provided only as an aid to understanding the modalities illustrated in this description and are not intended to be limiting in any way. Nor do these phrases indicate any preference for the modality disclosed.

[0020] In the first aspect, the present description refers to a flavor-modifying composition, which comprises: a) one or more flavoring oils, b) one or more agents for masking undesirable notes, c) one or more non-polar surfactants, d) one or more polar surfactants, e) water, and f) one or more cosolvents miscible in water.

[0021] The one or more flavoring oils suitable for use in the flavor-modifying composition described herein may be any flavoring oil known to those commonly skilled in the art. These flavoring oils may be selected from synthetic flavoring oils and aromatic or flavoring oils, oleoresins and extracts derived from plants, leaves, flowers, fruits, and so forth, and combinations thereof.Representative, but not limited to, flavoring oils include spearmint oil, cinnamon oil, wintergreen oil (methyl salicylate), peppermint oil, Japanese mint oil, clove oil, bay leaf oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, cassia oil, and citrus oils, including, for example, lemon, orange, lime, grapefruit, yuzu, sudachi, and fruit essences, including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, melon, apricot, ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya, and so forth. Petition 870250080417, dated 08 / 09 / 2025, page 15 / 61 6 / 46

[0022] In one embodiment, one or more flavor oils are selected from the group consisting of mint oil, such as spearmint oil, peppermint oil, and Japanese mint oil; cinnamon oil, wintergreen oil (methyl salicylate), clove oil, bay leaf oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, cassia oil, and citrus oil. In one embodiment, one or more flavor oils comprise mint oil.

[0023] In some embodiments, the flavor-modifying composition may comprise more than one flavor oil.

[0024] The amount of one or more flavor oils present in the flavor-modifying composition is not particularly limited. However, in some embodiments, the flavor-modifying composition of the present description allows for a significantly higher concentration of flavor oil. In one embodiment, one or more flavor oils are present in an amount of 20% to 60%, typically 40% to 55%, by weight relative to the total weight of the composition.

[0025] One or more undesirable note-masking agents suitable for use in the flavor-modifying composition described herein may be any undesirable note-masking agents known to those of common skill in the art. Undesirable notes are undesirable flavor notes that may be present in the flavor-modifying composition or in a flavored product into which the flavor-modifying composition may be incorporated. Exemplary undesirable notes include, but are not limited to, bitter notes, medicinal notes, metallic notes, or any combination thereof, and are normally due to the presence of unpleasant flavorings. The perception of unpleasant flavors may be reduced by the use of undesirable note-masking agents, which are known to those skilled in the art. Exemplary undesirable note-masking agents include, but are not limited to, glycosylated natural steviol glycosides.

[0026] As used in this document, the term “natural steviol glycosides” refers to steviol glycosides naturally found in plants of Petition 870250080417, dated 08 / 09 / 2025, page 16 / 61 7 / 46 species Stevia rebaudiana, Stevia phlebophylla, or Rubus chingii. These compounds are glycosides of the diterpene steviol. Some non-limiting examples include stevioside, rebaudioside A, rebaudioside C, dulcoside A, and the like. As used herein, the term “glycosylated natural steviol glycosides” refers to compounds obtained by enzymatic glycosylation of natural steviol glycosides to increase the degree of glycosylation. As used herein, the term “GSG” is used interchangeably with “glycosylated natural steviol glycoside”.

[0027] Any suitable GSGs may be used in the various aspects and embodiments disclosed herein. Thus, the GSGs may have any suitable degree of additional glycosylation, and any suitable type of glycosylation. In some embodiments, the GSGs used in the flavor modification composition have a degree of glycosylation of at least 1.0, meaning that at least one mole of glucose has been enzymatically added to the natural steviol glycosides per mole of natural steviol glycoside. In some other embodiments, the GSGs used in the flavor-modifying composition have a degree of glycosylation of at least 1.1, or at least 1.2, or at least 1.3, or at least 1.4, or at least 1.5, or at least 1.6, or at least 1.7, or at least 1.8, or at least 1.9, or at least 2.0, or at least 2.1, or at least 2.2, or at least 2.3, or at least 2.4, or at least 2.5. The glycosylation may be of any suitable type.For example, in some embodiments, the glucose enzymatically added to natural steviol glycosides is alpha-glucose, beta-glucose, or a combination thereof. In some embodiments, the glucose enzymatically added to natural steviol glycosides is alpha-glucose. In some embodiments, the glucose enzymatically added to natural steviol glycosides is beta-glucose. In some embodiments, the glucose enzymatically added to natural steviol glycosides is a combination of alpha-glucose and beta-glucose. The glucose added by enzymatic glycosylation can be incorporated through any suitable connection. Typically, the added glucose units connect to other glucose units already present in the natural steviol glycoside. In some... Petition 870250080417, dated 08 / 09 / 2025, page 17 / 61 In 8 / 46 embodiments, the enzymatically added glucose units are added via 1,6 linkages, meaning that the glucose units add through position 1 of the added glucose unit and position 6 of the glucose unit already present in the natural steviol glycoside. In some other embodiments, the enzymatically added glucose units are added via 1,4 linkages. In some other embodiments, the enzymatically added glucose units are added via 1,2 linkages.

[0028] In one embodiment, one or more undesirable note masking agents comprise one or more glycosylated natural steviol glycosides.

[0029] The amount of one or more undesirable note-masking agents in the flavor-modifying composition, according to the present description, is not particularly limited. However, in a suitable embodiment, one or more undesirable note-masking agents are present in an amount of 0.01% to 5%, typically 0.2% to 4%, by weight relative to the total weight of the composition.

[0030] One or more non-polar surfactants suitable for use in the flavor-modifying composition described herein may be any non-ionic surfactants with a hydrophilic-lipophilic balance (HLB) value equal to or less than 10.

[0031] As used in this document, hydrophilic-lipophilic balance (HLB) refers to the balance between the hydrophilic (water-loving) and lipophilic (oil-loving) properties of a surfactant molecule. Surfactants are molecules that possess both hydrophilic and lipophilic parts. The HLB value of a surfactant is a numerical value that indicates its relative hydrophilic and lipophilic character. A high HLB value (typically 10 and above) indicates a more hydrophilic surfactant, while a low HLB value (typically below 10) indicates a more lipophilic surfactant. The HLB value is often used to determine the effectiveness of a surfactant in a specific application, such as emulsifying oils in water or water in oils, and is therefore a practical guideline in formulation. HLB can also be used to describe the relationship between the molecular masses of the hydrophilic and Petition 870250080417, dated 08 / 09 / 2025, page 18 / 61 9 / 46 lipophilic of an amphiphilic molecule (Griffin, WC Classification of surface-active agents by HLB. J. Soc. Cosmet. Chem. 1, 1949, 311-326).

[0032] Exemplary nonpolar surfactants include, but are not limited to, sorbitan fatty acid esters, typically selected from the group consisting of sorbitan monostearate (Span 60), sorbitan tristearate (Span 65), sorbitan monolaurate (Span 20), sorbitan monooleate (Span 80), sorbitan monopalmitate (Span 40), sorbitan trioleate (Span 85); lecithins, typically soy lecithin; (poly)glyceryl esters, typically glycerol monooleate; and mixtures thereof.

[0033] The amount of one or more nonpolar surfactants is not particularly limited. However, in a suitable embodiment, one or more nonpolar surfactants is / are present in an amount of 1% to 40%, typically 5% to 35%, by weight relative to the total weight of the composition.

[0034] One or more polar surfactants suitable for use in the flavor-modifying compositions of the present description may be any non-ionic surfactant with a hydrophilic-lipophilic balance (HLB) value greater than 10.

[0035] Exemplary polar surfactants include, but are not limited to, poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers, typically a triblock copolymer consisting of a hydrophobic polypropylene glycol core block flanked by two hydrophilic polyethylene glycol blocks (Poloxamer 407); one or more PEG sorbitan fatty acid esters, typically selected from the group comprising PEG sorbitan monolaurate (Polysorbate 20), PEG sorbitan monooleate (Polysorbate 80), PEG sorbitan monopalmitate (Polysorbate 40) and PEG sorbitan stearate (Polysorbate 60); PEG-modified hydrogenated castor oil (Cremophor RH40); sugar esters, typically sucrose monopalmitate and sucrose monolaurate; (Poly)glyceryl esters, such as decaglyceryl monooleate, alkyl glycosides and mixtures thereof.

[0036] The quantity of one or more polar surfactants is not particularly limited. However, in a suitable embodiment, one or more polar surfactants Petition 870250080417, dated 08 / 09 / 2025, page 19 / 61 10 / 46 are present in an amount of 1% to 40%, typically 5% to 35%, by weight relative to the total weight of the composition.

[0037] One or more water-miscible cosolvents suitable for use in the flavor-modifying composition of the present description may be any solvent or mixtures of solvents that are miscible with water. Exemplary water-miscible cosolvents include, but are not limited to, propylene glycol, glycerol, ethanol, triethyl citrate, triacetin, ethyl lactate, ethyl acetate, propanol, isopropanol, and mixtures thereof.

[0038] In some situations, ethanol may not be used in the flavor-modifying composition of the present description due, for example, to consumer demand for less astringent oral care products. Thus, in one embodiment, the flavor-modifying composition of the present description is ethanol-free. As used herein, the phrase "free of" means that there is no external addition of the material to which it refers and that there is no detectable quantity of the material that can be observed by analytical techniques known to a normally qualified craftsman, such as, for example, gas chromatography.

[0039] The amount of one or more water-miscible cosolvents is not particularly limited. However, in a suitable embodiment, one or more water-miscible cosolvents are present in an amount of 0.01% to 30%, typically 5% to 25%, by weight relative to the total weight of the composition.

[0040] The flavor-modifying composition of the present description can be characterized by the weight ratio of one or more flavoring oils to one or more undesirable note-masking agents. In one embodiment, the weight ratio of one or more flavor oils to one or more undesirable note-masking agents is in the range of 20:1 to 100:1.

[0041] In some embodiments, the flavor-modifying composition is in the form of a water-in-oil microemulsion.

[0042] As understood by a person with ordinary skill in the art, an emulsion, such as a macroemulsion, a nanoemulsion, or a microemulsion, is a mixture of two liquids that are immiscible due to their different Petition 870250080417, dated 09 / 08 / 2025, p. 20 / 61 11 / 46 Polarities (hydrophobic vs. hydrophilic). In an emulsion, one liquid (dispersed, discontinuous, or internal phase) is dispersed in another liquid (external or continuous phase). One liquid is typically polar and the other liquid is typically nonpolar. Therefore, the nonpolar phase can be dispersed within the polar phase, or the polar phase can be dispersed within the nonpolar phase. When the nonpolar phase, typically an oily phase, is dispersed within the polar phase, typically an aqueous phase, this emulsion is an oil-in-water emulsion. When the polar phase is dispersed within the nonpolar phase, the emulsion is a water-in-oil emulsion.

[0043] Double emulsions are known, such as water-in-oil-in-water (WOO) emulsions and their opposite, oil-in-water-in-oil (OWO) emulsions, with three distinct phases. With regard to the WOO type, the three distinct phases consist of polar phase droplets that are dispersed in a non-polar phase, which is then enclosed in a continuous polar phase. Such triphasic emulsions are not contemplated in the present description. Therefore, the emulsions of the present description are not double emulsions, that is, the emulsions of the present description are not water-in-oil-in-water (WOO) emulsions or oil-in-water-in-oil (OWO) emulsions.

[0044] In one embodiment, the water-in-oil microemulsion comprises: a') a discontinuous aqueous phase comprising one or more agents for masking undesirable notes and water; and b') a continuous oily phase comprising one or more flavoring oils.

[0045] The compositions according to the present description are transparent at room temperature (RT) and are stable within a wide temperature range (e.g., RT ± 10-20 °C, typically between 10 °C and 45 °C, more typically between 3 °C and 45 °C) and for an extended period, typically a few days, more typically a few weeks, even more typically a few months or more.

[0046] The term transparent means that the mixtures in the absence of coloring or fluorescent agents have transmittance values ​​in visible light (500-800 nm) of 100% in a 1 cm path referenced against demineralized water.

[0047] The term stable means that the mixtures do not separate into phases and Petition 870250080417, dated 08 / 09 / 2025, page 21 / 61 12 / 46 remain clear, with no detectable signs of turbidity, cloudiness or precipitation.

[0048] The flavor-modifying compositions described in this document can be prepared according to methods known to those with common skill in the art. A suitable method comprises: a') prepare an oil phase by mixing one or more flavoring oils, one or more non-polar surfactants, one or more polar surfactants and one or more water-miscible solvents and, optionally, heating the combination, normally to a temperature of 30 °C to 50 °C, while stirring until a homogeneous liquid is obtained; b') prepare an aqueous phase by mixing one or more undesirable note-masking agents with water and stirring, usually at room temperature, until complete dissolution of one or more undesirable note-masking agents; and c') mix the oil phase prepared in step a') and the aqueous phase prepared in step b') while stirring, usually at room temperature, until a homogeneous liquid is obtained, usually a water-in-oil microemulsion.

[0049] In the second aspect, the present description refers to a flavored product comprising the flavor-modifying composition described in this document and an unpleasant flavor agent.

[0050] The amount of the flavor-modifying composition in the flavored product is not particularly limited. In one embodiment, the flavor-modifying composition is present in an amount of 0.001% to 5%, typically 0.01% to 1%, more typically 0.1% to 0.5%, by weight relative to the total weight of the flavored product.

[0051] In one embodiment, the flavored product is a food product, a beverage product, an oral care product, or a pharmaceutical product.

[0052] In some embodiments, the flavored product further comprises a cooling compound, a cooling-enhancing compound, a sweetener other than steviol glycosides or mogrosides, or a combination thereof. Petition 870250080417, dated 08 / 09 / 2025, page 22 / 61 13 / 46

[0053] As used in this document, a “refreshing compound” refers to a compound that modulates the TRPM8 receptor.

[0054] Exemplary cooling compounds include, but are not limited to, compounds selected from the group consisting of: (-)-menthol, Netyl-p-mentyl-3-carboxamide, cubebol, isopulegol, 3-(L-mentoxy)propane-1,2-diol, cis / trans-p-mentane-3,8-diol, 3-(L-mentoxy)-2-methylpropane-1,2-diol, 2-[2-(p-mentan-3-yloxy)ethoxy]ethanol, menthoxyethanol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl)ethenone, (1R,2R,5R)-N-ethyl-5-methyl-2-(prop-1-en-2-yl)-cyclohexanecarboxamide, N-(3-Hydroxy-4methoxyphenyl)-2-isopropyl-5,5-dimethyl-cyclohexanecarboxamide, N-[4-(cyanomethyl)phenyl]2-isopropyl-5,5-dimethyl-cyclohexanecarboxamide, N-(2-Hydroxy-2-phenylethyl)-2-isopropyl5,5-dimethyl-cyclohexane-1-carboxamide, L-menthol lactate, (-)-menthyl ethylene glycol carbonate, (-)-menthone 1,2-glycerol ketal, D / L-menthone 1,2-glycerol ketal, (-)-menthyl propylene glycol carbonate, 2-propylene glycol carbonate (-)-menthyl, 1-propylene glycol carbonate D / L-menthyl,2-propylene glycol carbonate of D / L-menthyl, (1 R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclo-hexanocarboxamide, ethyl starch oxalate of menthyl, (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide, ácido 3,4-metilenodioxicinâmico, N,N-difenylamide, N,N-dimetil (-)-menthyl succinimide, (1R,2S,5R)-N-(4-(carbamoylmetil)fenyl)-menthylcarboxamide, pirrolidona carboxilato de (-)-menthyl, L-fenilefrin p-menthyl carboxamide, (1R,2S,5R)-N-(4-(cyanomethyl)phenyl)menthylcarboxamida, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamida, 6isopropyl-3,9-dimethyl-1,4-dioxaspiro[4.5]decane-2-ona, (1 R,2R,4S)-di-hidroumbelulol, N-ethyl-p-menthan-3-carboxamida, 2-isopropyl-N,2,3-trimethylbutyramida, 3-(p-menthan3-carboxamido)ethyl acetate, N-ethyl-2,2-di-isopropylbutanamida, N-(1,1-dimethyl-2hidroxyethyl)-2,2-dimethylbutanamide, N-cyclopropyl-5-methyl-2-isopropyl-cyclohexanocarbonecarboxamida, (-)-mentila acetoacetate, (-)-mentila succinate, (S)-3-hidroxybutyrato de (-)-mentila,(-)-mentyl glutarate, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one, di-(-)-mentyl glutarate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide and any combinations thereof.

[0055] In some embodiments, the refreshing compound may be a refreshing compound disclosed in document no. WO 2021 / 074281, such as, Petition 870250080417, dated 09 / 08 / 2025, p. 23 / 61 14 / 46 por exemplo, (2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)(1,2,3-thiadiazol-5-yl)metanona, (2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)(thietan-3-yl)metanona,(2,2dimetilciclopropil)(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)metanona,(2ethoxyciclopropil)(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1-yl)metanona,(2methoxyciclopropil)(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)metanona,(2 methylcyclopropyl)(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1-yl)methanone, (2S)-2-methyl-1-(2 (5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1-yl)butan-1-one, (5-methyltetrahydrofuran-3-yl)(2(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)methanone, (E)-1 -(2-(5-(3,4-difluorophenyl)-1 Himidazol-2-yl)piperidin-1-yl)-2-methylbut-2-en-1-one, (E)-2-methyl-1-(2-(5-(p-tolyl)-1Himidazol-2-yl)piperidin-1-yl)but-2-en-1-one, (E)-2-methyl-1-(2-(5-(p-tolyl)-1 H-imidazol-2yl)piperidin-1 -yl)pent-3-en-1 -ona, il)piperidin-1 -yl)propan-1 -ona, il)piperidin-1 -yl)propan-1 -ona, il)piperidin-1 -yl)propan-1 -ona,il)piperidin-1 -yl)butan-1 -ona, il)piperidin-1 -yl)methanone, (R)-2-(methylthio)-1 -((R)-2-(5-(p-tolyl)-1 H-imidazol-2(S)-2-(methylthio)-1-((R)-2-(5-(p-tolyl)-1H-imidazol-2(S)-2-(methylthio)-1 -((S)-2-(5-(p-tolyl)-1 H-imidazol-2(S)-2-methyl-1 -((R)-2-(5-(p-tolyl)-1 H-imidazol-2(tetra-hidrofuran-3-yl)(2-(5-(p-tolyl)-1H-imidazol-21-(2-(1 H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-1-one, 1-(2-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)2-(methylthio)propan-1-one, 1 -(2-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-1 H-imidazol-2yl)piperidin-1 -yl)-2-(methylthio)propan-1 -ona, 1 -(2-(4-(2,3-di-hidrobenzofuran-5-yl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2,3-di-hydrobenzofuran-6-yl)-1 H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2,5-dimethylphenyl)1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-chlorophenyl)-1Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one,1-(2-(4-(2-cyclopropylxazol-5-yl)1 H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-fluorophenyl)-1 Himidazol-2-yl-piperidin-2-pan-methyl)-2(1-methyl) 1-(2-(4-(2-hydroxyphenyl)-1Himidazol-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(3((dimethylamino)methyl)phenyl)-1 H-imidazol-2-ylmethyl-piperidine)-2-pan-1 1(2-(4-(4-(3,5-difluorophenyl))-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propane-1-one, 1-(2(4-(3,5-dimethylisoxazol-4-yl)-1 H-promidazol-2-2-pan-methyl)pyridine) -ona, 1 (2-(4-(3-chloro-4-methylphenyl)-1 H-imidazol-2-yl)piperidine-1 -yl)-2-(methylthio)propan-1 -ona, 1 Petition 870250080417, dated 08 / 09 / 2025, p. 24 / 61, 15 / 46 (2-(4-(3-methylfuran-2-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -ona, 1 -(2(4-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-1 H-imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-l-one, 1-(2-(4-(4-(1-hidroxyethyl)phenyl)-1 H-imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-l-one, 1 -(2-(4-(4-(difluoromethoxy)-3-fluorophenyl)-1 H-imidazol-2yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1 -(2-(4-(4-(difluoromethyl)thiophen-3-yl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-(methylsulfonyl)phenyl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-(tert-butyl)phenyl)-1Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-cyclobutylphenyl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-cyclopropyl-2fluorophenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1 -(2-(4-(4fluorophenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one,1 -(2-(4-(4hydroxyphenyl)-1H-imidazol-2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1 -(2-(4-(4isopropylphenyl)-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4methyl-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1(2-(4-(5-((dimethylamino)methyl)thiophen-2-yl)-1H-imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, -(2-(4-(5-methylfuran-2-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)-21 -(2-(4-(5-methylpyridin-3-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)-21 -(2-(4-(6-methylpyridin-3-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)-21 -(2-(4-(benzo[b]thiophen-6-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)-21 -(2-(4-methyl-5-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)-21 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)-2((trifluoromethyl)thio)ethane-1-ona, 1-(2-(4-phenyl-1H-imidazol-2-yl)piperidin-1-yl)butan-1ona, 1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)hexa-3,5-dien-1 -ona, 1 -(2-(4-phenyl-1 Himidazol-2-yl)piperidin-1-yl)pent-4-en-1-ona, 1-(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1yl)propan-1-ona, 1-(2-(5-(2,3-difluorophenyl)-1H-imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-1 -ona, 1 -(2-(5-(2,4-difluorophenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2(methylthio)propan-1 -one, 1 -(2-(5-(2,5-difluorophenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2(methylthio)propan-1-one,1-(2-(5-(2-fluoro-4-methoxyphenyl)-1 H-imidazol-2-yl)piperidin-1-yl)2-(methylthio)propan-1 -one, 1 -(2-(5-(2-fluoro-4-methylphenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)2-(methylthio)propan-1-one, 1-(2-(5-(2-methoxypyrimidin-5-yl)-1 H-imidazol-2-yl)piperidin-1Petição 870250080417, de 08 / 09 / 2025, pág. 25 / 61, 16 / 46 yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-(methylamino)phenyl)-1H-imidazol-2-yl)piperidin-1yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3,4-difluorophenyl)-1H-imidazol-2-yl)piperidin-1-yl)2-(methylthio)propan-1 -one, methylbut-3-en-1-one, (methylthio)propan-1-one, (methylthio)propan-1-one, 1-(2-(5-(3,4-difluorofenil)-1 H-imidazol-2-yl)piperidin-1-yl)-21-(2-(5-(3,4-dimethoxyphenyl)-1 H-imidazol-2-yl)piperidin-1-yl)-21 -(2-(5-(3,4-dimethylfenil)-1 H-imidazol-2-yl)piperidin-1-yl)-21 -(2-(5-(3-fluoro-4-(methoxymetil)fenil)-1 H-imidazol-2 il)piperidin-1-yl)-2-(metilthio)propan-1-ona, 1-(2-(5-(3-fluoro-4-metilfenil)-1H-imidazol-2yl)piperidin-1 -yl)-2-(metilthio)propan-1-one H-imidazol-2yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-methoxyisothiazol-4-yl)-1H-imidazol2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-methoxyphenyl)-1H-imidazol-2yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-((methylamino)methyl)phenyl)-1Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(2-methoxyethyl)phenyl)-1Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(aminometil)fenil)-1Himidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-one,1-(2-(5-(4-(dimethylamino)fenil)1 H-imidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-ona, 1-(2-(5-(4-(hidroximetil)fenil)1 H-imidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-one Himidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-ona, 1-(2-(5-(4-aminofenil)-1Himidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-ona, 1-(2-(5-(4-chloro-3-fluorofenil)-1Himidazol-2-yl)propan-1-one, 1-(2-(5-(4-chlorophenyl)-1Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-ethylphenyl)-1H-imidazol2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1-(2-(5-(4-fluorophenyl)-4H-1,2,4-triazol-3yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1-(2-(5-(4-methoxy-2-methylphenyl)-1H-imidazol2-yl)piperidin-1-yl)-2-(methylthio)propan-1 -one, 1-(2-(5-(4-methoxyphenyl)-1H-imidazol2-yl)piperidin-1-yl)-2-(methylthio)propan-1 -one, 1 -(2-(5-(4-metil-6-(metilthio)pyridin-3-yl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(metilthio)propan-1-one,1-(2-(5-(5-(methoxymethyl)thiophen-3yl)-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(6-methoxypyridin-3yl)-1H-imidazol-2-yl)piperidin-1 -yl)-2-(methylthio)propan-1 -one, 1-(2-(5(benzo[d][1,3]dioxol-5-yl)-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 1-(2-(5-benzyl-1H-imidazol2-yl)piperidin-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-bromo-1 H-imidazol-2-yl)piperidinPetição 870250080417, de 08 / 09 / 2025, pág. 26 / 61, 17 / 46 -yl)-2-(methylthio)propan-1 -one, 2-(2-(1-(2-(methylthio)propanyl)piperidin-2-yl)-1 Himidazol-5-yl)benzonitrile, 2-(2-(4-phenyl-1 H-imidazol-2-yl bonitrila carbonyl)piperidine-1 2-(5-methylfuran-2-yl)-1-(2-(4-phenyl-1 H-imidazol-2yl)piperidin-1-yl)propan-1-one, 2-(allylthio)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-one) 2-(dimethylamino)-1-(2-(4-phenyl-1H-imidazol-2-yl)piperidin-1-yl)butan-1ona, 2-(dimethylamino)-1-(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1-yl)propan) 2-l-yl-ona -(2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)propan-1 -ona, 2-(furan-2-yl)-1 (2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)ethane-1-2-()-furan, -(2-(4-phenyl-1 Himidazol-2-yl)piperidin-1-yl)propan-1-ona, 2-(furan-3-yl)-1-(2-(4-phenyl-1H-imidazol-2yl)piperidin-1-yl)ethane-1-ona, 2-(furan-3-yl)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1yl)propan-1 -one, 2-(methylamino)-N-(4-(2-(1-(2-(methylthio)propanoyl)piperidyl-1-5-acetamyl-yl)2-(methylsulfinyl)-1 -(2-(5-(p-tolyl)-1 H -imidazol-2yl)piperidin-1 -yl)propan-1 -ona, 2-(methylsulfonyl)-1 -(2-(4-fenil-1 H -imidazol-2-yl)piperidin1 -yl)ethan-1 -one, 2-(metilthio)-1 -(2-(2-(p-tolyl)-2H-tetrazol-5-yl)piperidin-1 -yl)propan-1 -one, 2(metilthio)-1 -(2-(3-fenil-1,2,4-oxadiazol-5-yl)piperidin-1 -yl)propan-1 -one (2-(4-(1-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2(methylthio)-1-(2-(4-(4-(morpholinomethyl)phenyl)-1H-imidazol-2-yl)piperidin-1 -yl)propan-1-one, 2-(methylthio)-1-(2-(4-(5-(trifluoromethyl)furan-2-yl)-1H-imidazol-2-yl)piperidin-1 yl)propan-1 -one, 2-(methylthio)-1-(2-(4-(5-(trifluoromethyl)thiophen-2-yl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(5-methylthiophen-3-yl)-1H-imidazol-2-yl)piperidin-1 -yl)propan-1 -one, 2-(methylthio)-1-(2-(4-(m-tolyl)-1H-imidazol-2-yl)piperidin-1 yl)propan-1-one,2-(methylthio)-1-(2-(4-(o-tolyl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(pyridin-3-yl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2(methylthio)-1 -(2-(4-(pyridin-4-yl)-1 H-imidazol-2-yl)piperidin-1 -yl)propan-1 -one, 2-(methylthio)-1-(2-(4-(pyridin-5-yl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(quinoxalin-6-yl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4(thiophen-3-yl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-phenyl-1 Himidazol-2-yl)piperidin-1-yl)ethan-1-one, 2-(methylthio)-1-(2-(5-(2-(trifluoromethyl)phenyl)-1Himidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(2,3,4-trifluorophenyl)-1HPetição 870250080417, de 08 / 09 / 2025, p. 27 / 61, 18 / 46 imidazol-2-yl)piperidin-1-yl)propan-1-ona, 2-(metilthio)-1-(2-(5-(2,4,5-trifluorofenil)-1Himidazol-2-yl)piperidin-1-yl)propan-1-ona 2-(metilthio)-1-(2-(5-(4(trifluoromethoxy)fenil)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(metilthio)-1-(2-(5(4-(trifluorometil)fenil)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one H-imidazol-2-yl)piperidin-1-yl)propan-1-ona, 2-(metilthio)-1-(2-(5-(4vinilfenil)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-ona, 2-(metilthio)-1-(2-(5-(5metilthiofen-2-yl)-1 H-imidazol-2-yl)piperidin-1-yl)propan-1-ona -(2-(5-(ptolyl)-1,3,4-oxadiazol-2-yl)piperidin-1 -yl)propan-1 -ona, 2-(metilthio)-1 -(2-(5-(p-tolyl)-1 Himidazol-2-yl)azepan-1 -yl)propan-1 -ona 2-(methylthio)-1-(2-(5-(p-tolyl)-4H-1,2,4-triazol-3yl)piperidin-1-yl)propan-1-one,2-(methylthio)-1 -(2-(5-(p-tolyl)isoxazol-3-yl)piperidin-1 l)propan-1 -one, 2-(methylthio)-1 -(2-(5-(p-tolyl)oxazol-2-yl)piperidin-1 -methyl)propan-1, (methyl)propan-1 -(2-(5-(p-tolyl)thiazol-2-yl)piperidin-1 -yl)propan-1 -one, 2-(methylthio)-1 -(2-(5-phenyl1 H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-(1-(methylthio-1-) H-imidazol-2yl)pyrrolidin-1 -yl)propan-1 -ona, 2-(methylthio)-1 -(2-(5-phenyl-4H-1,2,4-triazol-3-yl)piperidin-1yl)propan-1 -ona, 2-(methylthio)-(pirixa)-1 din-2-(2 -yl)propan-1 -ona, 2(methylthio)-1 -(4-(5-(p-tolyl)-1 H-imidazol-2-yl)thiazolidin-3-yl)propan-1 -ona, 2,2,3-trimethyl-1 (2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)but-3-en-1-one, 2,2,3-trimethyl-1-(2-(5-(ptolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1 Himidazol-2-yl)piperidin-1-yl)but-3-en-1-ona, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1 H-imidazol-2yl)ona),piperidin-1-yl 2,3-dimethoxy-1-(2-(4-phenyl-1H-imidazol-2-yl)piperidin-1yl)propan-1 -ona, 2,3-dimethyl-1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)butan-1 -one, 2,5-difluoro-4-(2-(1-(2-(2-(methylthio)propanoyl)piperidin-2-yl)-1H-triimidazol)benzol-4 2-amino-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-cyclobutyl-1-(2(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)propan-1-2-cyclopene, -(2-(4-phenyl1 H-imidazol-2-yl)piperidin-1 -yl)ethane-1 -ona, 2-cyclopropyl-1 -(2-(4-phenyl-1 H-imidazol-2yl)piperidin-1-yl)ethane-1-ona, 2-cyclopropyl-1(4-1-(2-2 H-imidazol-2-yl)piperidin-1yl)propan-1-ona, 2-cyclopropyl-2-methoxy-1-(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1yl)ethane-1 -ona, 2-ethoxy-1 -(2-(5-(5-(3)-1-flu) H-imidazol-2-yl)piperidin-1 -yl)propane-1 Petition 870250080417, dated 08 / 09 / 2025, p. 28 / 61, 19 / 46 ona, 2-ethyl-1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)but-2-en-1 -ona, 2-ethyl-1 -(2-(4phenyl-1H-imidazol-2-yl)piperidin-1-ylone),butane 2-fluoro-4-(2-(1-(2(methylthio)propanoyl)piperidin-2-yl)-1H-imidazol-5-yl)benzonitrile, 2-mercapto-1-(2-(5-(ptolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-methoxy-1-(2-(4-phenyl-1H-imidazol2-yl)piperidin-1-yl)butan-1-one, 2-methoxy-1-(2-(4-phenyl-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-methoxy-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-metil-1-(2-(4-fenil-1 H-imidazol-2-yl)piperidin-1-yl)butan-1-ona, 2-metil-1-(2-(4-fenil1 H-imidazol-2-yl)piperidin-1-yl)propan-1-ona, 2-metil-1-(2-(5-(p-tolyl)-1 H-imidazol-2-yl)but-3-en-1 -one -(2-(5-(p-tolyl)-1 H -imidazol-2-yl)piperidin-1 yl)butan-1 -one, 2-metil-1 -(2-(5-(p-tolyl)-1 H -imidazol-2-yl)piperidin-1 -yl)butane-1,3-dione, 2-methyl-1 -(2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)pentan-1 -ona, 2-methyl-1 -(2-(5-(ptolyl)-1H-imidazol-2-yl)piperidin-1,-en-prop-ona 2-methyl-1-(2-(5-(p-tolyl)-1 Himidazol-2-yl)piperidin-1-yl)propan-1-one, 2-methyl-2-(methylthio)-1-(2-(5-(p-tolyl)-1 Himidazol-2-yl)piperipropan-1-yl)one 2-methyl-3-(methylthio)-1-(2-(4-phenyl-1H-imidazol2-yl)piperidin-1-yl)propane-1-one, 2-methylene-1-(2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin1-proonone-yltributane),yln-1 3-(2-(1-(2-(methylthio)propanoyl)piperidin-2-yl)-1 H-imidazol-43,3,3-trifluoro-2-methyl-1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 3,3,4,4,4-pentafluoro-1-(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1yl)butan-1 -one, 3,3-difluoro-1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)butan-1 -one, 3fluoro-4-(2-(1-(2-(methylthio)propanoyl)piperidin-2-yl)-1 H-imidazol-5-yl)benzonitrila, 3methyl-1 -(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)but-2-en-1 -one, 3-methyl-1 -(2-(4-phenyl1H-imidazol-2-yl)piperidin-1-yl)butan-1-one, 4-(2-(1-(2-(methylthio)propanoyl)piperidin-2yl)-1 H-imidazol-4-yl)benzonitrile, 4-(2-(1-(2-(methylthio)propanoyl)piperidin-2-yl)-1Himidazol-5-yl)benzaldeído, 4,4,4-trifluoro-2-methyl-1-(2-(4-phenyl-1 H-imidazol-2yl)piperidin-1 -yl)butan-1 -one, bicyclo[1.1.1 ]pentan-1 -yl(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1-yl)methanone, cyclobutyl(2-(5-(3-fluorophenyl)-1 H-imidazol-2-yl)piperidin-1-yl)methanone, cyclopentyl(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1-yl)methanone, cyclopropyl(2-(4-phenyl-1 H-imidazol-2-yl)piperidin-1 -yl)methanone, 4-(2-(1 -(2(methylthio)propanoyl)piperidin-2-yl)-1H-imidazol-5-yl)benzoate de methyl, N-(2-hydroxyethyl)4-(2-(1-(2-(methylthio)propanoyl)piperidin-2-yl)-1 H-imidazol-4-yl)benzenesulfonamida, 2 Request 870250080417, dated 09 / 08 / 2025, pág. 29 / 61. 20 / 46 (metiltio)-1-(2-(5-(3-nitrofenil)-1 H-imidazol-2-il)piperidin-1-il)propan-1-ona, N-(4-(2-(1(2-(metiltio)propanoil)piperidin-2-il)-1 H-imidazol-4-il)fenil)methane-sulfonamida, 2(metiltio)-1-(2-(5-(4-nitrofenil)-1 H-imidazol-2-il)piperidin-1-il)propan-1-ona, 1-(secbutilsulfinil)-2-(5-(p-tolil)-1 H-imidazol-2-il)piperidina, 1-(sec-butilsulfonil)-2-(5-(p-tolil)1 H-imidazol-2-il)piperidina, 1 -(isopropilsulfinil)-2-(5-(p-tolil)-1 H-imidazol-2il)piperidina, 1-(isopropilsulfonil)-2-(5-(p-tolil)-1 H-imidazol-2-il)piperidina, 1-((1(metiltio)etil)sulfinil)-2-(5-(p-tolil)-1 H-imidazol-2-il)piperidina, 1 -((1 (metiltio)etil)sulfonil)-2-(5-(p-tolil)-1 H-imidazol-2-il)piperidina, 1-((2-(metiltio)propan-2il)sulfinil)-2-(5-(p-tolil)-1H-imidazol-2-il)piperidina, 1-((2-(metiltio)propan-2-il)sulfonil)2-(5-(p-tolil)-1 H-imidazol-2-il)piperidina, 1 -(but-3-en-2-ilsulfinil)-2-(5-(p-tolil)-1 Himidazol-2-il)piperidina, 1-(but-3-en-2-ylsulfonil)-2-(5-(p-tolil)-1 H-imidazol-2il)piperidina,1 -(pent-3-en-2-ylsulfinyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 1 -(pent3-en-2-ylsulfonyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 1 -((2-methylbut-3-en-2yl)sulfinyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 1 -((2-methylbut-3-en-2-yl)sulfonyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 1 -(2-(5-(4-(hydroxymethyl)-phenyl)-1 H-imidazol-2yl)piperidine-1 -yl)-2-methylbutan-1 -one, 2-(methylsulfonyl)-1 -(2-(5-(p-tolyl)-1 H-imidazol-2yl)piperidin-1 -yl)propan-1 -one, 1 -(4-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)2-(methylthio)propan-1-ona, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)-2(methylthio)propan-1 -one, 1 -(4-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2methylbutan-1-ona, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)-2methylbutan-1-ona, 1-(2-(5-(4-(hydroxymethyl)phenyl)-1-one) H-imidazol-2-yl)piperidin-1-yl)-2-(methylsulfonyl)propane-1 -she,1 -(4-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2(methylsulfonyl)propan-1 -one, 1 -(5-hydroxy-2-(5-(p-tolyl)-1 H-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1-methyl-propanyl-1) -one, 1 -(2-hydroxy-6-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2(methylthio)propan-1 -one, 1 -(2-hydroxy-6-(5-(p-tolyl)-1 H-hydroxy-6-(5-(p-tolyl)-1 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)-2(methylsulfonyl)propan-1 -one, 1 -(3-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-2-promethione-2-(panylthion) 1 -(3-hydroxy-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2methylbutan-1-one, 1-(3-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)-2(methyl-1-ylphonone), 1-(2-(5-(4-(hydroxymethyl)phenyl)-1 H-imidazol-2-yl)piperidine-1, Petition 870250080417, of 08 / 09 / 2025, p. 30 / 61 21 / 46 yl)-2-(methylsulfinyl)-propan-1-one, 1-(4-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1 yl)-2-(methylsulfinyl)propan-1-one, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1 yl)-2-(methylsulfinyl)propan-1-one, 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1 yl)-2-(methylsulfinyl)propan-1-one, 1-(3-hydroxy-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1 yl)-2-(methylsulfinyl)propan-1 -one, 1-(2-hydroxy-6-(5-(4-(hydroxymethyl)phenyl)-1 H-imidazol-2yl)piperidin-1 -yl)-2-(methylthio)propan-1 -ona, 1 -(5-hydroxy-2-(5-(4-(hydroxymethyl)phenyl)-1 Himidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1-ona, 1-(4-hydroxy-2-(5-(4(hydroxymethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl) 1-(3hydroxy-2-(5-(4-(hydroxymethyl)-phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-2-(methylthio)propan-1one, 1 -(2-hydroxy-6-(5-(4-(hydroxymethyl)phenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2methylbutan-1 -one,1 -(5-hidroxi-2-(5-(4-(hidroximethyl)phenyl)-1 H-imidazol-2-yl)piperidin-1 yl)-2-methylbutan-1-ona, 1-(4-hidroxi-2-(5-(4-(hidroximethyl)phenyl)-1H-imidazol-2yl)piperidin-1 -yl)-2-methylbutan-1 -ona, 1 -(3-hidroxi-2-(5-(4-(hidroximethyl)phenyl)-1 Himidazol-2-yl)piperidin-1-yl)-2-methylbutan-1-ona, 4-(2-(1-(2-methylbutanoyl)piperidin-2-yl)1 H-imidazol-5-yl)benzaldeído, ácido 4-(2-(1-(2-(metiltio)propanoil)piperidin-2-yl)-1 Himidazol-5-il)benzoico, ácido 4-(2-(1-(2-metilbutanoil)piperidin-2-yl)-1 H-imidazol-5yl)benzoico, (2,2-dimetilciclopropyl)(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1yl)metanona, 1-(2-(5-bromo-1H-imidazol-2-yl)piperidin-1-yl)-2-metilbutan-1-ona, 1-(2(5-(4-clorophenil)-1 H-imidazol-2-yl)piperidin-1-yl)-2-metilbutan-1-ona, 2-(4-(2-(1-(2(methylthio)propanoyl)piperidin-2-yl)-1 H-imidazol-5-yl)phenyl)acetonitrile, 2-(4-(2-(1-(2methylbutanoyl)piperidin-2-yl)-1 H-imidazol-5-yl)phenyl)acetonitrile, 2-(4-(2-(1-(2methylbutanoyl)piperidin-2-yl)-1H-imidazol-5-yl)phenyl)acetonitrile, 2,3-dimethyl-1-(2-(5-(ptolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one, 2-methyl-1-(2-(5-(o-tolyl)-1 H-imidazol-2yl)piperidin-1-yl)butan-1-one, 2-methyl-1-(2-(5-(m-tolyl)-1 H-imidazol-2-yl)piperidin-1yl)butan-1 -one, 1 -(2-(5-(4-(hydroxymethyl)phenyl)-1 H-imidazol-2-yl)piperidin-1 -yl)-2methylbutyl-one, 1 -(isopropylsulfonyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 1 -(secbutylsulfonyl)-2-(5-(p-tolyl)-1 H-imidazol-2-yl)piperidine, 2-methyl-1 -(2-(5-(5-methyl)-phenyl) H-imidazol-2-yl)piperidin-1-yl)butan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)-1 H-imidazol2-yl)piperazin-1 -yl)propan-1 -one, 2-(methylthio)-1 -(2-(4-perylzol)-oxa- yl)propan-1 -one, 2-methyl-1 -(2-(4-(p-tolyl)oxazol-2-yl)piperidin-1 -yl)butan-1 -one, or, Petition 870250080417, of 08 / 09 / 2025, p. 31 / 61 22 / 46 any combination thereof.

[0056] In some embodiments, the refreshing compound may be 2-methyl-1(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)1H-imidazol-2-yl)piperidin-1-yl)propan-1-one, 2-methyl-2-(methylthio)-1-(2-(5-(p-tolyl)-1Himidazol-2-yl)piperidin-1-yl)propan-1-one, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazol-2yl)piperidin-1-yl)but-3-en-1-one or a combination thereof.

[0057] In some embodiments, the cooling compound may be 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole, 5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole (including fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole thereof. (3aR,5R,7S,7aR)-5-(4(3aR,5R,7R,7aR)-5-(4(3aR,5R,7S,7aS)-5-(4any combination or

[0058] As used herein, a refreshment-enhancing compound refers to a compound capable of enhancing the refreshing sensation provided by a flavored product that has a refreshing compound, but may also provide a refreshing sensation on its own. Such refreshment-enhancing compounds include, but are not limited to, naturally derived compounds such as menthol or analogues thereof, or synthetic compounds such as any compounds set forth in U.S. Patents No. 9,394,287 and No. U.S. 10,421,727.Exemplary refreshment-enhancing compounds include, among others, compounds selected from the group consisting of N-ethyl-N-(thiophene-2-ylmethyl)-2-(p-tolyloxy)acetamide; N-(1H-pyrazol-3-yl)-N(thiopheno-2-ylmethyl)-2-(p-tolyloxy)acetamide 2-(4-fluorophenoxy)-N-(1H-pyrazol-3-yl)-N(thiophen-2-ylmethyl)acetamide; 2-(2-hydroxy-4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2ylmethyl)-acetamide; 2-((2,3-dihydro-1 H-indeno-5-yl)oxy)-N-(1 H-pyrazol-3-yl)-N-(thiopheno-2ylmethyl)-acetamide; 2-((2,3-dihydro-1 H-indeno-5-yl)oxy)-N-(1 H-pyrazol-3-yl)-N-(thiazol-5ylmethyl)-acetamide; 5-methoxy-N-(1 H-pyrazol-3-yl)-N-(thiophene-2-ylmethyl)benzofuran-2carboxamide; 2-(4-ethylphenoxy)-N-(1 H-pyrazol-3-yl)-N-(thiopheno-2-ylmethyl)acetamide; (E / Z)2-methyl-2-butenal; (E / Z)-2-isopropyl-5-methyl-2-hexenal; derivatives, such as os. Petition 870250080417, of 08 / 09 / 2025, p. 32 / 61 23 / 46 established in document no. WO 2022 / 170519, and any combinations thereof.

[0059] The flavored product may additionally comprise a sweetener. The sweetener may include a low-calorie, zero-calorie, or high-intensity sweetener. The term “high-intensity sweetener” refers to sweeteners that are sweeter than sucrose, such as at least 10 times, or at least 20 times, or at least 50 times, or at least 100 times, or at least 250 times, or at least 500 times, or at least 750 times, or at least 10000 times, or at least 2500 times, or at least 5000 times, or at least 7500 times, or at least 10000 times sweeter than sucrose. In this context, to say that a sweetener is x times sweeter than sucrose means that a concentration of 1 / x by weight relative to sucrose in an aqueous solution of said sweetener yields an equivalent sweetness to sucrose.

[0060] Examples of suitable sweeteners are presented in more detail below. In some embodiments, the sweetener is sucralose, which refers to 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside. In some embodiments, the sweetener is sodium saccharin. Sodium saccharin may be present in any suitable concentration. In some embodiments, the concentration of sodium saccharin ranges from 10 ppm to 10,000 ppm, or from 50 ppm to 5,000 ppm, or from 100 ppm to 3,000 ppm.

[0061] In some embodiments, the sweetener may contain caloric sugars, such as sucrose, glucose, fructose (for example, in the form of high-fructose corn syrup) or any combination thereof. In some embodiments, the sweetener comprises one or more high-intensity artificial sweeteners, such as acefulfame potassium, aspartame, cyclamate, neotame and the like. When such high-intensity artificial sweeteners are present, their concentration would be approximately the same as that established above for sucralose. In some other embodiments, the sweetener comprises one or more low-calorie carbohydrates or sugar alcohols, such as allulose, xylitol, erythritol and the like.

[0062] Several other sweeteners may also be included in the product. Petition 870250080417, dated 08 / 09 / 2025, page 33 / 61 24 / 46 flavored as described herein. Non-limiting examples include D-psicose, L-ribose, D-tagatose, L-glucose, L-fucose, L-arabinose, D-turanose, D-leucrose, isomalt, lactitol, mannitol, sorbitol, maltodextrin, saccharin, alitame, cyclamic acid, tagatose, maltose, galactose, mannose, lactose, D-tryptophan, glycine, maltitol, lactitol, isomalt, hydrogenated starch hydrolysate (HSH), chemically modified mogrosides (such as glycosylated mogrosides), carellame and other guanidine-based sweeteners, honey, Jerusalem artichoke syrup, licorice root, monk fruit (fruit, powder or extracts), lucuma (fruit, powder or extracts), maple sap (including, for example, sap extracted from Acer saccharum, Acer nigrum, Acer rubrum, Acer saccharinum, Acer platanoides, Acer negundo, Acer macrophyllum, Acer grandidentatum, Acer glabrum, Acer mono), maple syrup, maple sugar, walnut sap (including, for example, sap extracted from Juglans cinerea,Juglans nigra, Juglans ailatifolia, Juglans regia), birch sap (including, for example, sap extracted from Betula papyrifera, Betula alleghaniensis, Betula lenta, Betula nigra, Betula populifolia, Betula pendula), sycamore sap (such as, for example, sap extracted from Platanus occidentalis), ironwood sap (such as, for example, sap extracted from Ostrya virginiana), muscovado sugar, molasses (such as, for example, molasses mixture), molasses sugar, monatina, monellin, cane sugar (also called natural sugar, unrefined cane sugar or sucrose), palm sugar, panocha, piloncillo, rapadura, raw sugar, rice syrup, sorghum, sorghum syrup, cassava syrup (also called tapioca syrup), thaumatin, yacon root, syrup of Malt, barley malt syrup, barley malt powder, beet sugar, cane sugar, crystal juice, caramel, carbitol, locust bean syrup, castor sugar, hydrogenated starch hydrolates.Hydrolyzed cane juice, hydrolyzed starch, invert sugar, anethole, arabinogalactan, arrope, syrup, P-4000, acesulfame potassium (also known as acesulfame K or ace-K), alitame (also known as aclame), advantame, aspartame, baiunoside, neotame, benzamide derivatives, bernadame, canderel, carrelame and other guanidine-based sweeteners, vegetable fiber, corn sugar, coupling sugars, curculin, cyclamates, cyclocaryoside I, demerara, Petition 870250080417, dated 08 / 09 / 2025, page 34 / 61 25 / 46 dextran, dextrin, diastatic malt, dulcine, sucrose, valzine, dulcoside A, dulcoside B, emulin, enoxolone, maltodextrin, saccharin, estragole, ethyl maltol, glucine, gluconic acid, gluconolactone, glucosamine, glucuronic acid, glycerol, glycine, glycyphylline, glycyrrhizin, glycyrrhetinic acid monoglucuronide, golden sugar, brown sugar, golden syrup, granulated sugar, ginostema, hernandulcine, isomerized liquid sugars, jallab, chicory root dietary fiber, kynurenine derivatives (including N'-formyl-kynurenine, N'-acetyl-kynurenine, 6-chloro-kynurenine), galactitol, litesse, ligican, licasin, lugduname, guanidine, falernum, mabinlin I, mabinlin II, maltol, maltisorb, maltodextrin, maltotriol, mannosamine, miraculin, mizuame, mukurozioside, nanosugar, naringin dihydrochalcone, neohesperidin dihydrochalcone, sugar nib, niger-oligosaccharide, norbu, orgeat syrup, osladin, pekmez, pentadin, periandrin I,perilaldehyde, perilartin, petfilin, phenylalanine, flomisoside I, phloridzin, phyllodulcin, polyglycolic syrups, polypodoside A, pterocarioside A, pterocarioside B, rebiana, refining syrup, rub syrup, rubusoside, selligueain A, shugr, siamenoside I, siraitia grosvenorii, soy oligosaccharide, Splenda, SRI oxime V, steviol glycoside, steviolbioside, stevioside, strogins 1, 2, and 4, sucronic acid, sucrononate, sugar, suosana, phloridzin, superaspartame, tetrasaccharide, threitol, molasses, trilobthin, tryptophan and derivatives (6-trifluoromethyltryptophan, 6-chloro-D-tryptophan), vanilla sugar, Volemitol, birch syrup, aspartame-acesulfame, assugrin, and combinations or mixtures of any two or more of these.

[0063] In some embodiments, the flavored product may comprise 4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one, or any suitable salt thereof. In some embodiments, the flavored product disclosed in this document may comprise the hydrochloride salt of 4-amino-5,6-dimethylthieno[2,3d]pyrimidin-2(1H)-one.

[0064] In some embodiments of any of the preceding embodiments, the flavored product may include a lactone. Any suitable lactone or combination of lactones may be used. In some embodiments, a lactone comprises a lactone ring having 3 to 8 ring members, such as a ring Petition 870250080417, dated 09 / 08 / 2025, p. 35 / 61 26 / 46 of a 3-membered lactone, a 4-membered lactone ring, a 5-membered lactone ring, a 6-membered lactone ring, a 7-membered lactone ring, or an 8-membered lactone ring.

[0065] In some embodiments, a lactone comprises a 5-membered lactone ring with or without an unsaturated linkage (excluding an unsaturation in the oxo substituent on the ring), such as a carbon-carbon double bond. In some embodiments, a lactone comprises a 5-membered lactone ring that includes at least one unsaturated linkage (for example, a carbon-carbon double bond). Non-limiting examples of lactones comprising a 5-membered lactone ring having at least one unsaturated linkage include angelica lactone alpha, angelica lactone beta, peppermint lactone, 5,5-dimethyl-2(5H)-furanone, 5-ethyl-2(5H)-furanone, 5-pentyl-2(5H)-furanone, 5-hexyl-2(5H)-furanone, 5-pentyl-2(3H)-furanone, 4-methyl-3-pentyl-2(5H)-furanone and 2(5H)-furanone. In some embodiments, a lactone comprises a 5-membered lactone ring without any unsaturated linkage.Non-limiting examples of such lactones include gamma butyrolactone, gamma valerolactone, gamma hexalactone, gamma heptalactone, gamma octalactone, gamma undecalactone, gamma decalactone, dihydrojasmone lactone, and dihydrominthlactone (3,6-dimethyl-hexahydro-2(3H)-benzofuranone).

[0066] In some embodiments, a lactone comprises a 6-membered lactone ring with or without an unsaturated linkage. In some embodiments, a lactone comprises a 6-membered lactone ring that includes at least one unsaturated linkage. Non-limiting examples of lactones comprising a 6-membered lactone ring having at least one unsaturated linkage include δ-2-decenolactone, coumarin, and 6-methylcoumarin. In some other embodiments, a lactone includes a 6-membered lactone ring without any unsaturated linkage. Non-limiting examples of lactones that include a 6-membered lactone ring without any unsaturated linkage include delta decalactone, delta dodecalactone, and cyclohexylactone.

[0067] In certain embodiments, the flavored product additionally comprises one or more food additives, including but not limited to: Petition 870250080417, dated 09 / 08 / 2025, pp. 36 / 61 27 / 46 acids, which include, for example, citric acid, phosphoric acid, ascorbic acid, sodium acid sulfate, lactic acid, or tartaric acid; bitter ingredients, which include, for example, caffeine, quinine, green tea, catechins, polyphenols, green robusta coffee extract, green coffee extract, potassium chloride, menthol or proteins (such as proteins and protein isolates derived from plants, algae or fungi); Coloring agents, which include, for example, caramel color, Red No. 40, Yellow No. 5, Yellow No. 6, Blue No. 1, Red No. 3, purple carrot, black carrot juice, purple sweet potato, vegetable juice, fruit juice, beta carotene, curcumin, turmeric, or titanium dioxide; preservatives, which include, for example, sodium benzoate, potassium benzoate, potassium sorbate, sodium metabisulfite, sorbic acid, or benzoic acid; Antioxidants that include, for example, ascorbic acid, calcium disodium EDTA, alpha tocopherols, mixed tocopherols, rosemary extract, grape seed extract, resveratrol, or sodium hexametaphosphate; Vitamins or functional ingredients, which include, for example, resveratrol, Co-Q10, omega-3 fatty acids, theanine, choline chloride (cytocholine), fibersol, inulin (chicory root), taurine, panax ginseng extract, guanana extract, ginger extract, L-phenylalanine, L-carnitine, L-tartrate, D-glucuronolactone, inositol, bioflavonoids, Echinacea, ginkgo biloba, yerba mate, flaxseed oil, garcinia cambogia peel extract, white tea extract, ribose, milk thistle extract, grape seed extract, pyridoxine HCl (vitamin B6), cyanobalamin (vitamin B12), niacinamide (vitamin B3), biotin, calcium lactate, calcium pantothenate (pantothenic acid), calcium phosphate, calcium carbonate, chromium chloride, polynicotinate chromium, cupric sulfate, folic acid, ferric pyrophosphate, iron, magnesium lactate, magnesium carbonate, magnesium sulfate, monopotassium phosphate, monosodium phosphate, phosphorus, potassium iodide, potassium phosphate,riboflavin, sodium sulfate, sodium gluconate, sodium polyphosphate, sodium bicarbonate, thiamine mononitrate, vitamin D3, vitamin A palmitate, Petition 870250080417, dated 08 / 09 / 2025, page 37 / 61 28 / 46 zinc gluconate, zinc lactate or zinc sulfate; Cloud-making agents, which include, for example, ester gum, brominated vegetable oil (BVO), or sucrose acetate isobutyrate (SAIB); buffers, which include, for example, sodium citrate, potassium citrate or salt; Flavors, which include, for example, natural flavor, natural flavor with other natural flavors (WONF natural flavor), natural and artificial flavors, artificial flavor; or starches and stabilizers, which include, for example, pectin, xanthan gum, carboxymethylcellulose (CMC), polysorbate 60, polysorbate 80, medium-chain triglycerides, cellulose gel, cellulose gum, sodium caseinate, modified food starch, gum arabic (acacia gum), inulin, or carrageenan.

[0068] In some additional embodiments, the flavored product disclosed herein comprises one or more other umami or kokumi enhancing compounds. These umami enhancing compounds include, but are not limited to, naturally derived compounds such as ericamica, or synthetic compounds, or any compounds disclosed in U.S. Patents No. 8,735,081; No. 8,124,121; and No. 8,968,708.

[0069] In some additional embodiments, the flavored product disclosed herein may comprise one or more bitterness-blocking compounds. Such bitterness-blocking compounds include, but are not limited to, naturally derived compounds such as menthol or analogues thereof, or synthetic compounds such as any compounds set forth in U.S. Patents Nos. 8,076,491; 8,445,692; and 9,247,759.

[0070] In some additional embodiments, the flavored product disclosed herein may comprise one or more mouthfeel-modifying compounds. These mouthfeel-modifying compounds include, but are not limited to, tannins, cellulosic materials, bamboo powder, and the like.

[0071] In some additional embodiments, the flavored product disclosed herein may comprise one or more masking compounds. Petition 870250080417, dated 08 / 09 / 2025, pp. 38 / 61 29 / 46 Flavor. Such flavor-masking compounds include, but are not limited to, cellulosic materials, materials extracted from fungi, materials extracted from plants, citric acid, carbonic acid (or carbonates), and the like.

[0072] In certain embodiments, the flavored product disclosed herein may comprise cyclosalt. When cyclosalt is present, it is present in a relative concentration similar to that of the lactones described herein.

[0073] In some embodiments, the flavored product comprises one or more flavorings, or any other additives described in H. Mitchell, Sweeteners and Sugar Alternatives in Food Technology, Blackwell Publishing Ltd, 2006. Useful flavorings are artificial, natural and synthetic fruit flavors, such as vanilla. Other potential flavors include a milk flavor, a butter flavor, a cheese flavor, a cream flavor and a yogurt flavor; a vanilla flavor; tea or coffee flavors, such as a green tea flavor, an oolong tea flavor, a tea flavor, a cocoa flavor, a chocolate flavor and a coffee flavor; mint flavors, such as a peppermint flavor, a spearmint flavor and a Japanese mint flavor;spicy flavors, such as asafoetida flavor, ajowan flavor, anise flavor, angelica flavor, fennel flavor, allspice flavor, cinnamon flavor, chamomile flavor, mustard flavor, cardamom flavor, caraway flavor, cumin flavor, clove flavor, pepper flavor, coriander flavor, sassafras flavor, salty flavor, Zanthoxyli Fructus flavor, perilla flavor, juniper berry flavor, ginger flavor, star anise flavor, horseradish flavor, thyme flavor, tarragon flavor, dill flavor, capsicum flavor, nutmeg flavor, basil flavor, marjoram flavor, rosemary flavor, bay leaf flavor, and wasabi (Japanese horseradish) flavor; Alcoholic flavors, such as a wine flavor, a whiskey flavor, a brandy flavor, a rum flavor, a gin flavor, and a liqueur flavor; floral flavors;and vegetable flavors, such as an onion flavor, a garlic flavor, a cabbage flavor, a carrot flavor, a celery flavor, flavor of; Petition 870250080417, dated 09 / 08 / 2025, pp. 39 / 61 30 / 46 mushroom and a tomato flavor. These flavoring agents can be used in liquid or solid form and can be used individually or in a mixture.

[0074] Flavors can also provide breath-freshening properties, particularly mint flavors when used in combination with cooling agents. These flavorings can be used in liquid or solid form and can be used individually or in mixtures. Other useful flavorings include aldehydes and esters, such as cinnamyl acetate, cinnamaldehyde, diethylacetal citral, dihydrocarvillal acetate, eugenyl formate, p-methylamisole, and so on. In general, any flavoring or food additive, such as those described in Chemicals Used in Food Processing, publication 1274, pages 63-258, by the National Academy of Sciences, can be used.

[0075] Additionally, examples of aldehyde flavorings include, but are not limited to, acetaldehyde (apple), benzaldehyde (cherry, almond), anisic aldehyde (licorice, anise), cinnamaldehyde (cinnamon), citral, i.e., alpha-citral (lemon, lime), neral, i.e., beta-citral (lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, cream), heliotrope, i.e., piperonal (vanilla, cream), vanillin (vanilla, cream), alpha-amyl cinnamaldehyde (spicy fruity flavors), butyraldehyde (butter, cheese), valeraldehyde (butter, cheese), citronellal (modifies, many types), decanal (citrus fruits), C-8 aldehyde (citrus fruits), C-9 aldehyde (citrus fruits), C-12 aldehyde (citrus fruits), 2-ethyl butyraldehyde (red fruits), hexenal, i.e., trans-2 (red fruits), tolyl aldehyde (cherry, almond), veratraldehyde (vanilla), 2,6-dimethyl-5-heptenal, i.e., melonal (melon), 2,6-dimethyloctanal (green fruit), and 2-dodecenal (citrus, tangerine), cherry, grape, strawberry cake,and mixtures thereof. These listings of flavorings are merely examples and are not intended to limit either the term "flavoring" or the scope of the description in general.

[0076] The flavored product may be any flavored product in accordance with the aspects and embodiments set forth below. In some embodiments, the flavored product is a beverage product, such as enhanced sparkling beverages, cola-type soft drinks, lime-lemon flavored sparkling beverages, Petition 870250080417, dated 08 / 09 / 2025, pages 40 / 61 31 / 46 Sparkling drinks with orange flavor, sparkling drinks with grape flavor, sparkling drinks with strawberry flavor, sparkling drinks with pineapple flavor, ginger ale-type soft drinks, root beer-type soft drinks, fruit juices, fruit-flavored juices, juice drinks, nectars, vegetable juices, vegetable-flavored juices, sports drinks, energy drinks, enhanced water drinks, vitamin-enriched water, near water-type drinks, coconut water, tea-type drinks, coffees, cocoa drinks, drinks containing milk components, drinks containing cereal extracts, and milkshakes. In some other embodiments, the flavored product is a food product, such as a packaged meal, canned foods, meal replacement products, and the like.In some embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, or a global whitening composition, such as a composition disclosed in Patent Application Publication No. US 2019 / 0167545, which is incorporated herein in its entirety by reference.

[0077] In some embodiments where the flavored product is a beverage, the beverage may be selected from the group consisting of intensified sparkling beverages, colas, lime-flavored sparkling beverages, orange-flavored sparkling beverages, grape-flavored sparkling beverages, strawberry-flavored sparkling beverages, pineapple-flavored sparkling beverages, ginger beers, root beers, fruit juices, flavored fruit juices, juice drinks, nectars, vegetable juices, flavored vegetable juices, sports drinks, energy drinks, intensified water drinks, vitamin-intensified water, near-water drinks, coconut waters, tea-type drinks, coffees, cocoa drinks, beverages containing dairy components, beverages containing cereal extracts, and smoothies. In some embodiments, the beverage may be a soft drink.

[0078] The flavored product may be in any suitable physical form. For example, in some embodiments, the flavored product may be in the form of a solid, such as a powder. In such a further embodiment, the flavored product is a teeth powder, such as a teeth whitening powder, removal Petition 870250080417, dated 09 / 08 / 2025, pp. 41 / 61 32 / 46 of stains (e.g., tobacco stains) and the like. In some other embodiments, the flavored product may be a paste or fluid paste, such as toothpaste. In some other embodiments, the flavored product may be in the form of a cream or gel, such as a tooth gel, skin cream, or toothpaste. In some other embodiments, the flavored product may be a liquid suspension or solution, for example, with an aqueous carrier. The flavored product may, in some embodiments, be in the form of an emulsion, such as a microemulsion or nanoemulsion, in which a surfactant, emulsifier, and the like may be present. In some embodiments, the flavored product is a personal care product, such as a product for application to the skin, face, lips, gums, mouth, and the like. Such personal products may be for any suitable use, such as skin whitening, teeth whitening, and the like.

[0079] In some embodiments, the flavored product is an oral care product. By “oral care product” is meant a personal care product or other product which, in the ordinary course of use, is not intentionally swallowed for the purpose of systemic administration of particular therapeutic agents, but is instead retained in the oral cavity for a time sufficient to come into substantial contact with all dental surfaces and / or oral tissues for purposes of oral activity. The oral care composition may be in various forms including toothpaste, powdered toothpaste, toothpaste, tooth gel, subgingival gel, mouthwash, mousse, foam, mouth spray, lozenge, chewable tablet, chewing gum or denture product. The oral care composition may also be incorporated into strips or films for direct application or fixation to oral surfaces.

[0080] In some embodiments, the flavored product is a pharmaceutical product, such as a product designed to carry or deliver certain active pharmaceutical ingredients (APIs). Such APIs may be over-the-counter (OTC) drugs, such as acetaminophen and other OTC cough or flu medications. In some embodiments, the API is a drug based on... Petition 870250080417, dated 09 / 08 / 2025, pp. 42 / 61 33 / 46 in prescription.

[0081] In certain embodiments of any aspects and embodiments set forth in this document that refer to a flavored product, the flavored product is a product that does not occur naturally, such as a packaged food or beverage product.

[0082] Additional non-limiting examples of food and beverage products or formulations include sweet toppings, glazes or toppings for such products or any entity included in the category Soup, in the category Dry Processed Food, in the category Beverage, in the category Ready Meal, in the category Canned or Preserved Food, in the category Frozen Processed Food, in the category Chilled Processed Food, in the category Snack Food, in the category Baked Goods, in the category Confectionery, in the category Dairy Products, in the category Ice Cream, in the category Meal Replacements, in the category Pasta and Noodles and in the category Sauces, Seasoned Sauces, Condiments, in the category Baby Food, and / or in the category Pâtés.

[0083] In general, the category of Soup refers to canned / preserved, dehydrated, instant, chilled, UHT, and frozen soup. For the purpose of this definition, soup (or soups) means a food prepared from meat, poultry, fish, vegetables, grains, fruits, and other ingredients, cooked in a liquid that may include visible pieces of some or all of these ingredients. It may be clear (like a broth) or thick (like a stew), creamy, puréed, or chunky, ready to serve, semi-condensed or condensed, and may be served hot or cold, as an appetizer or main course of a meal or as a snack between meals (taken as a beverage). Soup may be used as an ingredient to prepare other meal components and may range from broths (consommé) to sauces (cream or cheese-based soups).

[0084] The Culinary and Dehydrated Food Category normally means: (i) Kitchen aid products such as: powders, granules, pastes, concentrated liquid products including concentrated meat broth, meat broth and meat broth-like products in pressed cubes, tablets or powder form or Petition 870250080417, dated 08 / 09 / 2025, page 43 / 61 34 / 46 granulated, which are sold separately as a finished product or as an ingredient in a product, sauces and recipe mixes (regardless of technology); (ii) Meal solution products such as: dehydrated and freeze-dried soups, which include dehydrated soup mixes, instant dehydrated soups, ready-to-cook dehydrated soups, dehydrated or ambient preparations of ready-to-eat dishes, single-serving meals and entrees which include pasta, potato and rice dishes; and (iii) Meal embellishment products such as: condiments, marinades, seasoned salad dressings, salad toppings, dipping sauces, breaded products, mixer mixes, shelf-stable pâtés, barbecue sauces, liquid recipe mixes, concentrates, sauces or sauce mixes, which include salad recipe mixes, sold as a finished product or as an ingredient in a product, whether dehydrated, liquid or frozen.

[0085] The Beverage category generally means beverages, beverage mixes and concentrates, including, but not limited to, carbonated and non-carbonated beverages, alcoholic and non-alcoholic beverages, ready-to-drink beverages, liquid concentrate formulations for preparing beverages, such as soda-type soft drinks and dry powder beverage precursor mixes. The Beverage category also includes alcoholic beverages, soft drinks, sports drinks, isotonic drinks and hot beverages. Alcoholic beverages include, but are not limited to, beer, cider / pera, FABs, wine and spirits.Soft drinks include, but are not limited to, carbonated beverages such as colas and non-cola carbonated beverages; fruit juices such as juice, nectars, juice drinks and fruit-flavored drinks; bottled water, which includes sparkling water, spring water and purified / table water; functional beverages, which may be carbonated or non-carbonated and include sports drinks, energy drinks or elixirs; concentrates such as liquid and powdered concentrates in ready-to-drink form. Beverages, whether hot or cold, include, but are not limited to, coffee or iced coffee, such as fresh, instant and blended coffee; tea or iced tea, such as black, green, white, oolong and flavored tea; and other beverages that include powders, granules, blocks or tablets. Petition 870250080417, dated 08 / 09 / 2025, pp. 44 / 61 35 / 46 base flavor, malt or plant mixed with milk or water.

[0086] The Snack Food category generally refers to any food that can be a light, informal meal, including, but not limited to, sweet and savory snacks and snack bars. Examples of snack foods include, but are not limited to, fruit snacks, chips / crunchy snacks, extruded snacks, tortilla / corn chips, popcorn, pretzels, nuts, and other sweet and savory snacks. Examples of snack bars include, but are not limited to, granola / muesli bars, breakfast bars, energy bars, fruit bars, and other snack bars.

[0087] The Baked Goods category generally refers to any edible product whose preparation process involves exposure to excessive heat or sunlight. Examples of baked goods include, but are not limited to, bread, rolls, biscuits, muffins, cereals, toaster dough, pasta, waffles, tortillas, cookies, pies, bagels, open pies, quiches, cakes, any baked food and any combination thereof. Other examples include, but are not limited to, packaged / industrial bread, unpackaged / artisanal bread, packaged / industrial cakes, unpackaged / artisanal cakes, biscuits, chocolate-covered biscuits, filled biscuits, savory biscuits and cookies, bread substitutes, breakfast cereals, rte cereals, family breakfast cereals, flakes, muesli, other cereals, children's breakfast cereals and hot cereals.

[0088] The Ice Cream category generally refers to frozen desserts containing cream, sugar, and flavoring. Examples of ice cream include, but are not limited to, impulse ice cream; home-consumption ice cream; frozen yogurt and artisan ice cream; soy, oat, bean (e.g., red bean and mung bean), and rice-based ice creams. Other examples of ice cream include, but are not limited to, single-serving dairy ice cream, single-serving water ice cream, multi-package dairy ice cream, multi-package water ice cream, take-home dairy ice cream, ice cream desserts, bulk ice cream, and take-home water ice cream.

[0089] The Confectionery category generally refers to an edible product that is Petition 870250080417, dated 08 / 09 / 2025, pages 45 / 61 36 / 46 sweet to the palate. Examples of confectionery include, but are not limited to, candies, jellies, chocolate confectionery, sugar confectionery, gum and the like, and any combination products. Other examples include, but are not limited to, tablets, single bars, display products / bagged flexible products, boxed assortments, standard boxed assortments, wrapped miniatures, seasonal chocolate, chocolate with toys, alfajores, other chocolate confectionery products, candies, standard candies, mint candies, cooked candies, pastilles, gums, jellies and chewables, caramels, caramels and nougat, medicated confections, lollipops, licorice and other sugar confectionery products.

[0090] The category of Meal Replacements generally refers to any food intended to replace normal meals, particularly for people who have health or fitness concerns. Examples of meal replacements include, but are not limited to, weight loss products and convalescent drinks and convalescent products.

[0091] The Ready Meal category generally refers to any food that can be served as a meal without extensive preparation or processing. Ready meals include products that have had recipe skills added to them by the manufacturer, resulting in a high degree of readiness, completeness, and convenience. Examples of ready meals include, but are not limited to, canned / preserved, frozen, dried, chilled ready meals; dinner mixes; frozen pizza; chilled pizza; and prepared salads.

[0092] The Pasta and Noodles category includes any type of pasta and / or noodles, which includes, but is not limited to, canned, dried and fresh / chilled pasta; and plain, instant, chilled, frozen and snack noodles.

[0093] The Canned / Preserved Food category includes, but is not limited to, canned / preserved meat and meat products, fish / seafood, vegetables, tomatoes, beans, fruits, ready meals, soups, pasta and other canned / preserved foods. Petition 870250080417, dated 08 / 09 / 2025, pages 46 / 61 37 / 46

[0094] The Frozen Processed Food category includes, but is not limited to, frozen processed red meat, processed poultry, processed fish / seafood, processed vegetables, meat substitutes, processed potatoes, bakery products, desserts, ready meals, pizza, soup, pasta and other frozen foods.

[0095] The Dry Processed Food category includes, but is not limited to, rice, dessert mixes, dry ready meals, dehydrated soup, instant soup, dry pasta, plain noodles, and instant noodles. The Chilled Processed Food category includes, but is not limited to, chilled processed meats, processed fish / seafood products, lunch kits, fresh cut fruit, ready meals, pizza, prepared salads, soup, fresh pasta, and noodles.

[0096] The category Sauces, Seasoned Sauces and Condiments includes, but is not limited to, tomato pastes and purees, bouillon cubes / broth, herbs and spices, monosodium glutamate (MSG), table sauces, soy-based sauces, pasta sauces, wet / cooking sauces, dry sauces / powdered mixes, ketchup, mayonnaise, mustard, seasoned salad dressings, vinaigrettes, dipping sauces, pickled products, and other sauces, seasoned sauces and condiments.

[0097] The Baby Food category includes, but is not limited to, milk-based or soy-based formula; and prepared, dry and other baby foods.

[0098] The category Pâtés includes, but is not limited to, jams and preservatives, honey, chocolate pâtés, hazelnut-based pâtés and yeast-based pâtés.

[0099] The category Dairy Products generally refers to edible products produced from mammalian milk. Examples of dairy products include, but are not limited to, dairy drinkables, cheese, yogurt and sour milk drinks and other dairy products. Other examples of dairy products include, but are not limited to, fresh / pasteurized milk, fresh / pasteurized whole milk, fresh / pasteurized semi-skimmed milk, long-life / UHT milk, long-life / UHT whole milk, long-life / UHT semi-skimmed milk, long-life / UHT skimmed milk, goat's milk, condensed / evaporated milk, flavored milk, functional and other condensed milks, flavored milk drinks, dairy drinks only Petition 870250080417, dated 08 / 09 / 2025, pp. 47 / 61 38 / 46 flavored dairy products, flavored dairy drinks with fruit juice, soy milk, fermented dairy drinks, coffee bleaches, powdered milk, flavored powdered dairy drinks, cream, processed cheese, creamy processed cheese, non-spreadable processed cheese, unprocessed cheese, creamy cheese, packaged hard cheese, unpackaged hard cheese, natural / plain yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinkable yogurt, plain yogurt and probiotic yogurt.

[00100] In some embodiments, the flavored product comprises one or more candies, chocolate candies, tablets, single bars, display products / flexible products, boxed assortments, standard boxed assortments, twist-wrapped miniatures, seasonal chocolate, chocolate with toys, alfajores, other chocolate candies, mint candies, standard mint candies, potency mint candies, cooked candies, lozenges, gummies, jellies and chewables, caramels,Caramels and nougat, medicinal confections, lollipops, licorice, other sugar confections, bread, packaged / industrial bread, unpackaged / artisanal bread, sweets, cakes, packaged / industrial cakes, unpackaged / artisanal cakes, biscuits, chocolate-covered biscuits, cookies, sandwiches, filled biscuits, savory biscuits and crackers, bread substitutes, breakfast cereals, ready-to-eat cereals, family breakfast cereals, flakes, muesli, other cereals, children's breakfast cereals, hot cereals, ice cream, impulse ice cream, single-serving milk ice cream, single-serving water ice cream, multi-packaged milk ice cream, multi-packaged water ice cream, takeaway ice cream, takeaway milk ice cream, ice cream desserts, bulk ice cream, takeaway water ice cream, frozen yogurt, artisanal ice cream, dairy products, milk, fresh / pasteurized milk, fresh / pasteurized whole milk,Fresh / pasteurized semi-skimmed milk, UHT milk, UHT whole milk, UHT semi-skimmed milk, UHT skimmed milk, goat's milk, condensed / evaporated milk, plain condensed / evaporated milk, flavored condensed milk, functional and other flavored milk drinks, dairy-only flavored milk drinks, milk drinks flavored with fruit juice, soy milk, sour milk drinks, fermented milk drinks, whitening agents, Petition 870250080417, dated 08 / 09 / 2025, pages 48 / 61 39 / 46 of coffee, powdered milk, flavored powdered milk drinks, cream, cheese, processed cheese, spreadable processed cheese, non-spreadable processed cheese, unprocessed cheese, unprocessed spreadable cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, yogurt, plain / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinkable yogurt, regular drinkable yogurt, probiotic drinkable yogurt, refrigerated and shelf-stable desserts, milk-based desserts, soy-based desserts, refrigerated snacks, fresh cheese and quark cheese, plain fresh cheese and quark cheese, flavored fresh cheese and quark cheese, salted fresh cheese and quark cheese, sweet and savory snacks, fruit snacks, chips / potato chips, extruded snacks, tortilla / corn chips, popcorn, pretzels, nuts, other sweet and savory snacks, snack bars, granola bars, breakfast bars,Energy bars, fruit bars, other snack bars, meal replacement products, weight loss products, convalescent drinks, ready meals, canned ready meals, frozen ready meals, dry ready meals, refrigerated ready meals, dinner mixes, frozen pizza, refrigerated pizza, soup, canned soup, dehydrated soup, instant soup, refrigerated soup, hot soup, frozen soup, pasta, canned pasta, dried pasta, refrigerated / fresh pasta, noodle-type noodles, plain noodle-type noodles, instant noodle-type noodles, instant noodle-type noodles in a cup / bowl, instant noodle-type noodles in a sachet, refrigerated noodle-type noodles, snack noodle-type noodles, canned foods, canned meat and meat products, canned fish / seafood, canned vegetables, canned tomatoes, canned beans, canned fruits, canned ready meals, canned soup,canned pasta, other canned foods, frozen foods, frozen processed red meat, frozen processed poultry, frozen processed fish / seafood, frozen processed vegetables, frozen meat substitutes, frozen potatoes, oven-baked potato chips, other oven-baked potato products, frozen unbaked potatoes, frozen bakery products, frozen desserts, ready meals, Petition 870250080417, dated 08 / 09 / 2025, pp. 49 / 61 40 / 46 frozen, frozen pizza, frozen soup, frozen noodles, other frozen foods, dried foods, dessert mixes, dry ready meals, dehydrated soup, instant soup, dried pasta, plain noodles, instant noodles, instant noodles in a cup / bowl, instant noodles in a sachet, refrigerated foods, refrigerated processed meats, refrigerated fish / seafood products, refrigerated processed fish, refrigerated breaded fish, refrigerated smoked fish, refrigerated lunch kits, refrigerated ready meals, refrigerated pizza, refrigerated soup, refrigerated / fresh pasta, refrigerated noodles, oils and fats, olive oil, vegetable and seed oils, cooking fats, butter, margarine, spreading oils and fats, functional spreading oils and fats, sauces, seasonings and condiments, tomato pastes and purees, stock cubes, bouillon cubes, sauce granules, liquid stocks and bases, herbs and spices,Fermented sauces, soy-based sauces, pasta sauces, wet sauces, dry sauces / powdered mixes, ketchup, mayonnaise, regular mayonnaise, mustard, salad dressings, regular salad dressings, low-fat salad dressings, vinaigrettes, dipping sauces, canned goods, other sauces, seasonings and condiments, baby food, milk formula, standard milk formula, follow-on milk formula, infant milk formula, hypoallergenic milk formula, prepared baby food, dry baby food, other baby food, pastes, jams and preserves, honey, chocolate pastes, nut-based pastes and yeast-based pastes.

[00101] Some embodiments provide a flavored chewable product that may or may not be intended to be swallowed. In some embodiments, the flavored chewable product may be gum, chewing gum, sweetened gum, sugar-free gum, functional gum, bubble gum that includes compounds as disclosed and described herein, individually or in combination.

[00102] The flavored products disclosed in this document contain one or more compounds that users of these products perceive as having an undesirable taste, such as a bitter taste, a medicinal taste, or a metallic taste. As used in this document, such compounds are referred to as flavorings. Petition 870250080417, dated 09 / 08 / 2025, pp. 50 / 61 41 / 46 unpleasant. In some embodiments, the flavored product comprises an unpleasant flavoring agent, wherein that unpleasant flavoring agent is cetylpyridinium chloride, lauramidopropyl betaine, cocamidopropyl betaine, arginine, hydrogen peroxide, chlorhexidine gluconate, zinc phosphate, zinc chloride, zinc citrate, potassium nitrate, pentasodium triphosphate, tetrasodium pyrophosphate, stannous fluoride, sodium bicarbonate, thymol, menthol, methyl salicylate, eucalyptol, or any combination thereof. In some other embodiments, the unpleasant flavoring is thymol, menthol, methyl salicylate, eucalyptol, or any combination thereof. In some embodiments, the unpleasant taste is cetylpyridinium chloride, lauramidopropyl betaine, cocamidopropyl betaine, or any combination thereof. In some embodiments, the unpleasant flavoring agent is arginine. In some forms, the unpleasant-tasting agent is hydrogen peroxide.In some embodiments, the unpleasant taste is chlorhexidine gluconate. In some embodiments, the unpleasant flavoring is zinc phosphate, zinc chloride, zinc citrate, potassium nitrate, pentasodium triphosphate, tetrasodium pyrophosphate, stannous fluoride, or any combination thereof. In some embodiments, the unpleasant taste is sodium bicarbonate.

[00103] The unpleasant flavoring may be present in the flavored product in any appropriate quantity. For example, in embodiments where the flavored product is an oral hygiene product, the unpleasant flavor(s) may be present in any quantity typical for use with similar type oral hygiene products.

[00104] In the third aspect, the present description refers to the use of the flavor-modifying composition described herein to reduce the unpleasant taste of a flavored product. Unpleasant taste is often attributed to the presence of one or more unpleasant-tasting compounds that users of these products perceive as having an undesirable taste, such as a bitter taste, a medicinal taste, or a metallic taste. A method for reducing the unpleasant taste of a flavored product containing one or more unpleasant-tasting agents is also mentioned, the method comprising adding the composition. Petition 870250080417, dated 09 / 08 / 2025, pp. 51 / 61 42 / 46 flavor modifier for the flavored product.

[00105] The compositions, products and uses according to this description are further illustrated by the following non-limiting examples. EXAMPLE 1. FLAVOR-MODIFFERENTIATING COMPOSITIONS

[00106] Flavor-modifying compositions according to some aspects of the present description have been prepared and summarized in Tables 1a and 1b below. Unless otherwise indicated, the quantity of each ingredient is given as a percentage by weight relative to the total weight of the composition. TABLE 1A. Ingredient Composition 1 Composition 2 Composition 3 Composition 4 Peppermint Flavoring Oil 43.1 44.1 45.3 49.4 GSG 2.2 0.44 0.45 0.49 Span 20 28.0 28.7 7.1 6.2 Poloxamer 407 15.1 15.4 15.7 24.7 Propylene Glycol 3.0 3.0 Ethyl Lactate 22.8 9.8 Water 8.6 8.36 8.65 9.41 Peppermint Flavoring Oil / GSG Ratio 20 100 100 100 TABLE 1B. Ingredient Composition 5 Composition 6 Composition 7 Peppermint flavoring oil 41.8 42.1 44.7 Petition 870250080417, dated 08 / 09 / 2025, pages 52 / 61 43 / 46 GSG 0.42 0.42 0.45 Span 20 20.0 15.4 17.3 Poloxamer 407 18.3 9.6 14.2 Propylene glycol 0.4 8.4 13.7 Ethyl lactate 10.9 21.1 2.3 Water 8.3 3.0 7.4 41.8 42.1 44.7 Peppermint flavoring oil / GSG ratio 100 100 100

[00107] Samples 1-7 were prepared as follows:

[00108] Preparation of the oil phase: the flavoring oil, the non-polar and polar surfactants and the water-miscible solvent were mixed and heated under gentle stirring (45 °C) until a homogeneous liquid was obtained.

[00109] Preparation of the aqueous phase: The GSG was mixed with water and stirred at RT until the GSG was completely dissolved.

[00110] Preparation of water-in-oil microemulsion: the oil phase and the aqueous phase were mixed and stirred at RT until a homogeneous liquid was obtained.

[00111] The resulting compositions were transparent at room temperature (RT) and remained stable for at least three months. EXAMPLE 2. SENSORY EVALUATION

[00112] Samples 3 and 4 were evaluated in a sensory test. Two comparative toothpastes and two toothpastes according to some aspects of the present description were produced using the toothpaste base shown in Table 2. Two comparative toothpastes and two toothpastes according to some aspects of the present description are summarized in Table 3. TABLE 2. COMPOSITION OF TOOTHPASTE BASE Petition 870250080417, dated 08 / 09 / 2025, pages 53 / 61 44 / 46 Ingredient Concentration (%) Polyethylene glycol 400 2.0 Xanthan gum 0.60 Sorbitol (70% solution in water) 50.0 Sodium fluoride 0.22 Sodium benzoate 0.20 Hydrated silica (Tixosil 73) 22.0 Hydrated silica (Tixosil 43) 7.0 Titanium dioxide 0.50 Sodium lauryl sulfate 1.25 Flavor TBD Sodium saccharin TBD Water qs to 100% TABLE 3. TOOTHPASTE COMPOSITIONS Ingredient | Comparative Sample 1 | Comparative Sample 2 | Inventive Sample 3 | Inventive Sample 4 | Toothpaste Base | 96.0 | 96.0 | 96.0 | 96.0 | Saccharin (25% solution in H2O) | 0.8 | 0.8 | 0.8 | 0.8 | Peppermint Flavor | 1.0 | 1.0 | GSG | 0.01 Petition 870250080417, dated 08 / 09 / 2025, pages 54 / 61 45 / 46 Composition 3 2.0 Composition 4 2.0 Water 2.2 2.19 1.2 1.2

[00113] Sensory testers (panel of 4 experts) were asked to perform the following: (a) apply approximately 1-2 g of sample to the toothbrush, (b) rinse the toothbrush under running water for 5 seconds to moisten the paste and soften the bristles, (c) brush around the teeth for 1 minute, minimizing brushing of the gums, and (d) rate the intensity of the undesirable note during and 3 minutes after brushing using an intensity scale of 0 to 5 (where 0 indicates no intensity and 5 indicates very strong intensity). The results are presented in Table 4. TABLE 4. DURING BRUSHING Intensity of undesirable note (0-none, 5-Very strong) Bitterness 4.5 3.5 3 2 Astringency 4 4 5.5 3.5 Burning 1.5 1 1 1 3 MINUTES AFTER BRUSHING Intensity of undesirable note (0-none, 5-Very strong) Bitterness 1.5 2.5 1 1 Astringency 2 2.5 2.5 1.5 Burning 0.5 0.5 0.5 0.5

[00114] The disclosed matter has been described with reference to specific details of particular modalities thereof. Such details are not intended to be considered as limitations on the scope of the disclosed matter, except in Petition 870250080417, dated 09 / 08 / 2025, pp. 55 / 61 46 / 46 to the extent that they are included in the attached claims.

[00115] Therefore, the exemplary embodiments described herein are well adapted to achieve the aforementioned purposes and advantages, as well as those inherent in them. The particular embodiments disclosed above are merely illustrative, as the exemplary embodiments described herein may be modified and practiced in different but equivalent ways apparent to those of ordinary skill in the art who have the benefit of the teachings herein. Furthermore, no limitation is intended to the details of construction or design shown herein, except as described in the claims below. It is therefore evident that the particular illustrative embodiments disclosed above may be altered, combined, or modified, and all such variations are considered within the scope and spirit of the exemplary embodiments described herein.The illustrative modalities described in this document, as revealed herein, may be adequately practiced in the absence of any element not specifically disclosed in this document and / or any optional element disclosed in this document. Petition 870250080417, dated 09 / 08 / 2025, pp. 56 / 61

Claims

1 / 4 CLAIMS 1. Flavor-modifying composition characterized by comprising: a) one or more flavoring oils, b) one or more agents for masking undesirable notes, c) one or more non-polar surfactants, d) one or more polar surfactants, e) water, and f) one or more water-miscible cosolvents.

2. Flavor-modifying composition, according to claim 1, characterized in that one or more flavoring oils are selected from the group consisting of mint oil, such as spearmint oil, peppermint oil and Japanese mint oil; cinnamon oil, wintergreen oil (methyl salicylate), clove oil, laurel oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, cassia oil and citrus oil.

3. Flavor-modifying composition, according to claim 1 or 2, characterized in that one or more flavor oils are present in an amount of 20% to 60%, typically 40% to 55%, by weight relative to the total weight of the composition.

4. Flavor-modifying composition, according to any one of claims 1 to 3, characterized by one or more undesirable flavor-masking agents comprising one or more glycosylated natural steviol glycosides.

5. Flavor-modifying composition, according to any one of claims 1 to 4, characterized in that one or more undesirable flavor-masking agents are present in an amount of 0.01% to 5%, typically 0.2% to 4%, by weight relative to the total weight of the composition.

6. Flavor-modifying composition, according to any one of claims 1 to 5, characterized in that one or more non-polar surfactants each have a hydrophilic-lipophilic balance (HLB) value equal to or less than 10. Petition 870250080417, dated 08 / 09 / 2025, page 57 / 61 2 / 4 7. Flavor-modifying composition, according to any one of claims 1 to 6, characterized in that one or more nonpolar surfactants comprise one or more sorbitan fatty acid esters, typically selected from the group consisting of sorbitan monostearate (Span 60), sorbitan tristearate (Span 65), sorbitan monolaurate (Span 20), sorbitan monooleate (Span 80), sorbitan monopalmitate (Span 40), sorbitan trioleate (Span 85); lecithins, typically soy lecithin; (poly)glyceryl esters, typically glycerol monooleate; and mixtures thereof.

8. Flavor-modifying composition, according to any one of claims 1 to 7, characterized in that one or more nonpolar surfactants are present in an amount of 1% to 40%, typically 5% to 35%, by weight relative to the total weight of the composition.

9. Flavor-modifying composition, according to any one of claims 1 to 8, characterized in that one or more polar surfactants each have a hydrophilic-lipophilic balance (HLB) value greater than 10.

10. Flavor-modifying composition, according to any one of claims 1 to 9, characterized in that one or more polar surfactants are selected from the group consisting of poly(oxyethylene)poly(oxypropylene)-poly(oxyethylene) block copolymers, typically one or more triblock copolymers consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (Poloxamer 407); one or more PEG sorbitan fatty acid esters, typically selected from the group consisting of PEG sorbitan monolaurate (Polysorbate 20), PEG sorbitan monooleate (Polysorbate 80), PEG sorbitan monopalmitate (Polysorbate 40) and PEG sorbitan stearate (Polysorbate 60); PEG-modified hydrogenated castor oil (Cremophor RH40); sugar esters, typically sucrose monopalmitate and sucrose monolaurate;(Poly)glyceryl esters, such as decaglyceryl monooleate, alkyl glycosides and mixtures thereof.

11. Flavor-modifying composition, according to any one of claims 1 to 10, characterized in that one or more polar surfactants are present in an amount of 1% to 40%, typically 5% to 35%, by weight relative to the total weight of the composition.

12. Flavor-modifying composition, according to any one of claims 1 to 11, characterized in that one or more water-miscible cosolvents are selected from the group consisting of propylene glycol, glycerol, ethanol, triethyl citrate, triacetin, ethyl lactate, ethyl acetate, propanol, isopropanol and mixtures thereof.

13. Flavor-modifying composition, according to any one of claims 1 to 12, characterized in that one or more water-miscible cosolvents are present in an amount of 0.01% to 30%, typically 5% to 25%, by weight relative to the total weight of the composition.

14. Flavor-modifying composition, according to any one of claims 1 to 13, characterized in that the weight ratio of one or more flavoring oils to one or more undesirable note-masking agents is in the range of 20:1 to 100:

1.

15. Flavor-modifying composition, according to any one of claims 1 to 14, characterized in that the composition is in the form of a water-in-oil microemulsion.

16. Flavor-modifying composition, according to claim 15, characterized in that the water-in-oil microemulsion comprises: a') a discontinuous aqueous phase comprising one or more undesirable flavor-masking agents and water; and b') a continuous oily phase comprising one or more flavoring oils.

17. Flavored product characterized by comprising the flavor-modifying composition, as defined in any one of claims 1 to 16, and an unpleasant flavor agent.

18. Flavored product, according to claim 17, characterized in that the flavored product is an oral care product.

19. Use of the flavor-modifying composition, as defined in Petition 870250080417, dated 08 / 09 / 2025, pp. 59 / 61 4 / 4, any of claims 1 to 16, characterized by being for reducing the unpleasant taste of a flavored product. Petition 870250080417, dated 08 / 09 / 2025, pp. 60 / 61