COMPOUNDS, COMPOSITION, METHOD OF COMBATING PHYTOPATHOGENIC FUNGI AND SEED

Abstract

The present invention relates to the compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to their use and composition.

Description

1 / 159 “COMPOUNDS, COMPOSITION, METHOD OF COMBATING PHYTOPATHOGENIC FUNGI AND SEED”

[001] The present invention relates to novel pyridyl / pyrazidyl dihydrobenzothiazepine compounds, their salts and N-oxides, as well as their use as fungicides. The present invention also relates to a composition comprising at least one compound I, to a method of controlling phytopathogenic fungi, and to a seed coated with at least one compound of formula I.

[002] WO 2010 / 018686 describes some dihydrobenzothiazepine compounds. In many cases, however, particularly at low application rates, the fungicidal activity of known compounds is unsatisfactory. Therefore, an object of the present invention is to provide compounds with improved activity and / or a broader spectrum of activity against phytopathogenic fungi. Another object of the present invention is to provide fungicides with enhanced toxicological properties or with enhanced environmental fate properties.

[003] These and other objectives are achieved by dihydrobenzothiazepine compounds of formula (I), as defined below, and their salts suitable for agricultural use.

[004] Consequently, the present invention relates to compounds of formula I: in which: - Y is N or CR1; Z is S, SO, or SO2; Petition 870250083202, dated 09 / 16 / 2025, page 153 / 317 2 / 159 - R1 is selected independently in each case from H, halogen, CN, C1-C4 alkyl or C1-C4 alkyl halogen; - R2 is selected, independently in each case, from halogen, CN, C1-C6 alkyl, C1-C6 alkyl halogen, C2-C6 alkenyl, C2-C6 alkenyl halogen, C2-C6 alkynyl, C2-C6 alkynyl halogen, C1-C6 O-alkyl, C2-C6 O-alkenyl, C2-C6 O-alkynyl, C3-C6 cycloalkyl, C1-C6 S-alkyl, C2-C6 S-alkenyl or C2-C6 S-alkynyl; - R3 is selected, independently in each case, from halogen, CN, C1-C6 alkyl, C1-C6 alkyl halogen, C2-C6 alkenyl, C2-C6 alkenyl halogen, C2-C6 alkynyl, C2-C6 alkynyl halogen, C1-C6 O-alkyl, C2-C6 O-alkenyl, C2-C6 O-alkynyl, C3-C6 cycloalkyl, C1-C6 S-alkyl, C2-C6 S-alkenyl or C2-C6 S-alkynyl; - R4 is selected, independently in each case, from H, halogen, CN, C1-C4 alkyl or C1-C4 alkyl halogen; - R5 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R5a substituents; wherein - each R5a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; - R6 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms Petition 870250083202, dated 09 / 16 / 2025, p. 154 / 317 3 / 159 selected from N, O, and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2, or 3 R6a substituents; wherein - each R6a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; or - R5 and R6 together form an oxo group (=O) or a tioxo group (=S); or - R5 and R6, together with the carbon atom to which they are attached, form a saturated carbocyclic ring with 3, 4, 5 or 6 members or a saturated heterocyclic ring with 3, 4, 5 or 6 members containing 1, 2 or 3 heteroatoms selected from O and S as ring members; wherein the carbocyclic or heterocyclic ring is unsubstituted or carries 1, 2 or 3 R56 substituents; wherein - each R56 is independently halogen, C1-C6 alkyl or C1-C6 haloalkyl; - R7 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R7a substituents; wherein - each R7a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; - R8 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms Petition 870250083202, dated 09 / 16 / 2025, p. 155 / 317 4 / 159 selected from N, O, and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2, or 3 R8a substituents; wherein - each R8a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; or - R7 and R8, together with the carbon atom to which they are attached, form a saturated carbocyclic ring with 3, 4, 5 or 6 members or a saturated heterocyclic ring with 3, 4, 5 or 6 members containing 1, 2 or 3 heteroatoms selected from O and S as ring members; - X is selected, independently in each case, from halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2C6 alkynyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, phenyl, benzyl, phenoxy, benzoxy or C1-C6 thioalkyl; wherein phenyl, benzyl, phenoxy and benzoxy may be unsubstituted or substituted by halogen, CN, C1-C6 alkyl or C1-C6 haloalkyl; and - n is 0, 1, 2 or 3; with the caveat that, if Y is CR1, R5, R6, R7 and R8 cannot all be H; or their N-oxides, tautomers, stereoisomers or salts acceptable for agricultural use.

[005] N-oxides can be prepared from the compounds according to the present invention by following conventional oxidation methods, such as by treating compounds I with an organic peracid, such as metachloroperbenzoic acid (cf. WO 03 / 64572 or J. Med. Chem. 38 (11), 1892-903, 1995); or with inorganic oxidizing agents, such as hydrogen peroxide (cf. J. Heterocyc. Chem. 18 (7), 1305-8, 1981) or oxone (cf. J. Am. Chem. Soc. 123 (25), 5962-5973, 2001). The oxidation can generate pure mono-N-oxides or a mixture of different N-oxides, which can be separated by conventional methods, such as chromatography. Petition 870250083202, dated 09 / 16 / 2025, page 156 / 317 5 / 159

[006] Salts acceptable for agricultural use of the compounds of formula I include especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, do not have adverse effects on the fungicidal action of compounds I. Suitable cations are therefore particularly the ions of alkali metals, preferably sodium and potassium, of alkaline earth metals, preferably calcium, magnesium and barium, of transition metals, preferably manganese, copper, zinc and iron, as well as the ammonium ion which, if desired, may be substituted by one to four C1-C4 alkyl substituents and / or a phenyl or benzyl substituent, preferably di-isopropylammonium, tetramethylammonium, tetrabutylammonium or trimethylbenzylammonium, in addition to phosphonium ions, sulfonium ions, preferably tri(C1-C4 alkyl)sulfonium ions, and sulfoxonium ions, preferably tri(C1-C4 alkyl)sulfoxonium ions.

[007] Acceptable acid addition salt anions are mainly chloride, bromide, fluoride, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate and the C1-C4 alkanoic acid anions, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound I with an acid of the corresponding anion, preferably hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.

[008] The compounds of formula I may exist in the form of one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers arising from restricted rotation about a single bond of asymmetric groups, and geometric isomers. They are also part of the object of the present invention. Those skilled in the art will appreciate that a stereoisomer may be more active and / or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when Petition 870250083202, dated 09 / 16 / 2025, page 157 / 317 6 / 159 separated from the other stereoisomer(s). Furthermore, those skilled in the art know how to selectively separate, enrich and / or prepare said stereoisomers. The compounds according to the present invention may be present in the form of a mixture of stereoisomers, such as a racemate, individual stereoisomers, or as optically active forms.

[009] The compounds of formula I may be present in different crystal modifications, whose biological activity may be different. They are also part of the object of the present invention.

[0010] With respect to the variables, the realizations of the intermediates obtained during the preparation of compounds I correspond to the realizations of the compounds of formula I. The expression “compounds I” refers to the compounds of formula I.

[0011] The intermediate compounds are further described below. Those skilled in the art will readily understand that the preferences for substituents, particularly those given in the tables below for the corresponding substituents offered herein in relation to compounds I, apply appropriately to the intermediates. The substituents therefore have, in each case, independently of each other or, more preferably, in combination, the meanings defined herein.

[0012] If the synthesis produces mixtures of isomers, separation is generally not necessary, since in some cases the individual isomers can be interconverted during preparation for use or during application (for example, under the action of light, acids or bases). These conversions can also occur after use, such as in the treatment of plants in the treated plant, or in the harmful fungus to be controlled.

[0013] In the definitions of the variables given above, collective terms are used, which are generally representative of the substituents in question. The expression “Cn-Cm” indicates the number of carbon atoms. Petition 870250083202, dated 09 / 16 / 2025, pp. 158 / 317 7 / 159 possible in each case for the substituent or substituent portion in question.

[0014] The term “halogen” designates fluorine, chlorine, bromine and iodine.

[0015] The expression “C1-C6 alkyl” designates a saturated hydrocarbon group with a linear or branched chain of 1 to 6 carbon atoms, such as methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, and 1-ethyl-2-methylpropyl. Similarly, the expression "C2-C4 alkyl" indicates a linear or branched chain alkyl group with 2 to 4 carbon atoms, such as ethyl, propyl (n-propyl), 1-methylethyl (isopropyl), butyl, 1-methylpropyl (sec-butyl), 2-methylpropyl (isobutyl), and 1,1-dimethylethyl (tert-butyl).

[0016] The expression “C1-C6 alkyl halogen” designates an alkyl group with 1 or 6 carbon atoms as defined above, wherein the hydrogen atoms in these groups may be replaced, in whole or in part, by halogen atoms as mentioned above. Examples include "C1-C2 alkyl halogen" groups, such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, or pentafluoroethyl.

[0017] The expression “C2-C6 alkenyl” designates an unsaturated hydrocarbon radical with a linear or branched chain of 2 to 6 carbon atoms and a double bond at any position. Examples are “C2-C4 alkenyl” groups, such as ethenyl, 1-propenyl, 2-propenyl (allyl), 1 Petition 870250083202, dated 09 / 16 / 2025, p. 159 / 317 8 / 159 methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl and 2-methyl-2-propenyl.

[0018] The expression “C2-C6 alkenyl halogen” designates an alkyl group with 2 or 6 carbon atoms as defined above, wherein the hydrogen atoms in these groups may be replaced, in whole or in part, by halogen atoms, as mentioned above.

[0019] The expression “C2-C6 alkynyl” designates an unsaturated hydrocarbon radical with a linear or branched chain of 2 to 6 carbon atoms, containing at least one triple bond. Examples are “C2-C4 alkynyl” groups, such as ethinyl, prop-1-ynyl, prop-2-ynyl (propargyl), but-1-ynyl, but-2-ynyl, but-3-ynyl and 1-methylprop-2-ynyl.

[0020] The expression “C2-C6 alkynyl halogen” designates an alkyl group with 2 or 6 carbon atoms as defined above, wherein the hydrogen atoms in these groups may be replaced, in whole or in part, by halogen atoms, as mentioned above.

[0021] The expression “C3-C6 cycloalkyl” designates saturated monocyclic hydrocarbon radicals with 3 to 6 carbon ring members, such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Consequently, a saturated carbocyclyl or carbocyclo with three, four, five, six, seven, eight, nine or ten members is a “C3-C10 cycloalkyl”.

[0022] The expression “C3-C8 cycloalkyl C1-C4 alkyl” designates alkyl with 1 to 4 carbon atoms (as defined above), in which at least one hydrogen atom of the alkyl radical is replaced by a cycloalkyl radical with 3 to 8 carbon atoms (as defined above).

[0023] The expression “heterocycline or saturated or partially unsaturated heterocycle with three, four, five, six, seven, eight, nine or ten members, wherein the heterocycline or heterocycle contains 1, 2, 3 or 4 heteroatoms selected from N, O and S” should be understood as indicating Petition 870250083202, dated 09 / 16 / 2025, pp. 160 / 317 9 / 159 Saturated and partially unsaturated heterocycles, in which the ring member atoms of the heterocycle include, in addition to carbon atoms, 1, 2, 3, or 4 heteroatoms selected independently from the O, N, and S groups. For example: - saturated heterocycle with 3 or 4 members containing 1 or 2 heteroatoms of the group consisting of O, N and S as ring members, such as oxirane, aziridine, thirane, oxetane, azetidine, thietethane, [1,2]dioxetane, [1,2]dithetane and [1,2]diazetidine; - a saturated or partially unsaturated heterocycle with 5 or 6 members containing 1, 2, or 3 heteroatoms from the group consisting of O, N, and S as ring members, such as 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl, 4thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 1,2,4-oxadiazolidin-3-yl, 1,2,4-oxadiazolidin-5-yl, 1,2,4-thiadiazolidin-3-yl, 1,2,4-thiadiazolidin-5-yl, 1,2,4-triazolidin-3-yl, 1,3,4-oxadiazolidin-2-yl, 1,3,4-thiadiazolidin-2-yl, 1,3,4-triazolidin-2-yl, 2,3-di-hydrofur-2-yl, 2,3-di-hydrofur-3-yl, 2,4-di-hydrofur-2-yl, 2,4-di-hydrofur-3-yl, 2,3-di-hydrothien-2-yl, 2,3-di-hydrothien-3-yl, 2,4-di-hydrothien-2-yl, 2,4-di-hydrothyne-3-ila, 2-pyrroline-2-ila, 2-pyrroline-3-ila, 3pyrroline-2-ila, 3-pyrroline-3-ila, 2-isoxazolin-3-ila, 3-isoxazolin-3-ila, 4-isoxazolin-3ila, 2-isoxazolin-4-ila, 3-isoxazolin-4-ila, 4-isoxazolin-4-ila, 2-isoxazolin-5-ila, 3isoxazolin-5-ila, 4-isoxazolin-5-ila, 2-isothiazolin-3-ila, 3-isothiazolin-3-ila, 4isothiazolin-3-ila, 2-isothiazolin-4-ila, 3-isothiazolin-4-ila, 4-isothiazolin-4-ila, 2isothiazoline-5-ila, 3-isothiazolin-5-yl, 4-isothiazolin-5-yl, 2,3-di-hydropyrazol-1-yl, 2,3-di-hydropyrazol-2-yl, 2,3-di-hydropyrazol-3-yl, 2,3-di-hydropyrazol-4-yl, 2,3-dihydropyrazol-5-yl, 3,4-di-hydropyrazol-1-yl, 3,4-di-hidropirazol-3-ila, 3,4-diPetição 870250083202, de 16 / 09 / 2025, pág. 161 / 317, 10 / 159 hidropirazol-4-ila, 3,4-di-hidropirazol-5-ila, 4,5-di-hidropirazol-1-ila, 4,5-di hidropirazol-3-ila, 4,5-di-hidropirazol-4-ila, 4,5-di-hidropirazol-5-ila, 2,3-di-hidrooxazol-2-ila, 2,3-di-hidro-oxazol-3-ila, oxazol-5-ila, 3,4-di-hidro-oxazol-2-ila, oxazol-4-ila, 3,4-di-hidro-oxazol-5-ila, 2,3- di-hidro-oxazol-4-ila, 2,3-di-hidro 3,4-di-hidro-oxazol-3-ila, 3,4-di-hidro 3,4-di-hidro-oxazol-2-ila, 3,4-di-hidro oxazol-3-ila, 3,4-di-hidro-oxazol-4-ila, 2-piperidinila, 3-piperidinila, 4-piperidinila, 1,3-dioxan-5-ila, 2-tetra-hidropiranila, 4-tetra-hidropiranila, 2-tetra-hidrotienila, 3hexa-hidropiridazinila, 4-hexa-hidropiridazinila, 2-hexa-hidropirimidinila, 4-hexahidropirimidinila, 5-hexa-hidropirimidinila, 2-piperazinila, 1,3,5-hexa-hidrotriazin2-ila e 1,2,4-hexa-hidrotriazin-3-ila, bem como os radicais ilideno corresponding; e - saturated or partially unsaturated heterocycle with 7 members, such as tetra- and hexahydroazepinyl, such as 2,3,4,5-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or -7-yl, 3,4,5,6-tetrahydro[2H]azepin-2-,-3-,-4-,-5-,-6- or -7-yl, 2,3,4,7-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or -7-yl, 2,3,6,7-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or -7-yl, hexahydroazepin-1-,2-,-3- or -4-yl, tetra- and hexahydro-oxepinyl, such as 2,3,4,5-tetrahydro[1 H]oxepin-2-,-3-,-4-,-5-,-6- or -7-yl, 2,3,4,7-tetrahydro[1 H]oxepin-2-,-3-,-4,-5-,-6- or -7-yl, 2,3,6,7-tetrahydro[1H]oxepin-2-,-3-,-4-,-5-,-6- or -7-yl, hexahydroazepin-1-,-2-,-3- or -4-yl, tetra and hexahydro-1,3-diazepinyl, tetra and hexahydro-1,4-diazepinyl, tetra and hexahydro-1,3-oxazepinyl, tetra and hexahydro-1,4oxazepinyl, tetra and hexahydro-1,3-dioxepinyl, tetrahydro-1,4-dioxepinyl, and the corresponding ylidene radicals.

[0024] The term “replaced” means replaced by 1, 2, 3 or up to the maximum possible number of substitutes.

[0025] The expression “5- or 6-membered heteroaryl” or “5- or 6-membered heteroaromatic” indicates aromatic ring systems that include, in addition to carbon atoms, 1, 2, 3, or 4 selected heteroatoms. Petition 870250083202, dated 09 / 16 / 2025, p. 162 / 317 11 / 159 independently from the group consisting of N, O and S, such as: - heteroaryl com 5 members, such as pyrrol-1-ila, pirrol-2-ila, pyrrol-3-ila, tien-2-ila, tien-3-ila, furan-2-ila, furan-3-ila, pirazol-1-ila, pirazol-3-ila, pirazol-4-ila, pirazol-5-ila, imidazol-1-ila, imidazol-2-ila, imidazol-4-ila, imidazol-5ila, oxazol-2-ila, oxazol-4-ila, oxazol-5-ila, isoxazol-3-ila, isoxazol-4-ila, isoxazol5-ila, tiazol-2-ila, tiazol-4-ila, tiazol-5-ila, isotiazol-3-ila, isotiazol-4-ila, isotiazol-5ila, 1,2,4-triazolil-1-ila, 1,2,4-triazol-3-ila, 1,2,4-triazol-5-ila, 1,2,4-oxadiazol-3-ila, 1,2,4-oxadiazol-5-ila, 1,2,4-tiadiazol-3-ila e 1,2,4-tiadiazol-5-ila; ou - heteroaryl with 6 members, such as pyridin-2-ila, piridin-3-ila, piridin-4-ila, piridazin-3-ila, piridazin-4-ila, pirimidin-2-ila, pirimidin-4-ila, pirimidin-5-ila, pirazin-2-ila, 1,3,5-triazin-2-ila and 1,2,4-triazin-3-ila.

[0026] Specific embodiments of the compounds according to the present invention will be described below. In this descriptive report, specific meanings of the corresponding substituents are further detailed, wherein the meanings are, in each case, isolated, but also in any combination with each other in the specific embodiments of the present invention.

[0027] Furthermore, with regard to variables, the realizations of compounds I also generally apply to intermediates.

[0028] According to a realization of the compound of formula I, Y is N.

[0029] According to a realization of the compound of formula I, Y is CR1.

[0030] According to a realization of the compound of formula I, Z is S.

[0031] According to one embodiment of the compound of formula I, Z is SO.

[0032] According to one embodiment of the compound of formula I, Z is SO2.

[0033] According to one embodiment of the compound of formula I, R1 is selected independently in each case from H, halogen, CN, C1-C4 alkyl and C1-C4 halogen alkyl; preferably, R1 is selected independently in each case from H, C1-C4 alkyl and halogen alkyl. Petition 870250083202, dated 09 / 16 / 2025, page 163 / 317 12 / 159 C1-C4; more preferably, R1 is selected independently in each case from H and C1-C4 alkyl and, most preferably, R1 is, in each case, H.

[0034] According to an embodiment of the compound of formula I, R2 is selected from halogen, CN, C1-C6 alkyl, C1-C6 alkyl halogen, C2-C6 alkenyl, C2-C6 alkenyl halogen, C2-C6 alkynyl, C2-C6 alkynyl halogen, C1-C6 O-alkyl, C2-C6 O-alkenyl, C2-C6 O-alkynyl, C3-C6 cycloalkyl, C1-C6 S-alkyl, C2-C6 S-alkenyl and C2-C6 S-alkynyl.

[0035] According to one embodiment of the compound of formula I, R2 is selected independently in each case from C1-C4 alkyl and C1-C4 alkyl halogen; preferably, R2 is selected independently in each case from H, C1-C4 alkyl and C1-C4 alkyl halogen; most preferably, R2 is selected independently in each case from CH3 and CF2H and, most preferably, R2 is, in each case, CH3.

[0036] According to yet another embodiment of formula I, R2 is a halogen, particularly F, Cl, Br or I, more specifically F, Cl or Br and, particularly, F or Cl.

[0037] According to yet another realization of formula I, R2 is F.

[0038] According to yet another embodiment of formula I, R2eCl.

[0039] According to yet another realization of formula I, R2éBr.

[0040] According to yet another realization of formula I, R2eCN.

[0041] According to yet another embodiment of formula I, R2 is C1C6 alkyl, particularly C1-C4 alkyl, such as CH3 or C2H5, particularly CH3 or CH2CH3.

[0042] According to yet another embodiment of formula I, R2 is a C1-C6 alkyl halogen, particularly a C1-C4 alkyl halogen, such as CF3.

[0043] According to yet another realization of formula I, R2 is alkenyl Petition 870250083202, dated 09 / 16 / 2025, pp. 164 / 317 13 / 159 C2-C6, particularly C2-C4 alkenyl, such as CH=CH2, C(CH3)=CH2 or CH2CH=CH2.

[0044] According to yet another specific embodiment of formula I, R2 is a C2-C6 alkenyl halogen, particularly a C2-C4 alkenyl halogen, more specifically a C2-C3 alkenyl halogen, such as CH=CHF, CH=CHCl, CH=CF2, CH=CCl2, CH2CH=CHF, CH2CH=CHCl, CH2CH=CF2, CH2CH=CCl2, CF2CH=CF2, CCl2CH=CCl2, CF2CF=CF2 or CCl2CCl=CCl2.

[0045] According to yet another embodiment of formula I, R2 is C2-C6 alkynyl or C2-C6 alkynyl halogen, particularly C2-C4 alkynyl or C2-C4 alkynyl halogen, such as CΞCH, CH2CΞCH, CECCl, CH2CΞCCl or CCbCECCl.

[0046] According to yet another specific embodiment of formula I, R2 is C1-C6 O-alkyl, particularly C1-C4 alkyl, more specifically C1-C2 alkoxy. R2 is, for example, OCH3 or OCH2CH3.

[0047] According to yet another specific embodiment of formula I, R2 is C1-C6 O-alkyl.

[0048] According to yet another specific embodiment of formula I, R2 is C2-C6 O-alkenyl, particularly C2-C4 alkenyl, more specifically C2-C3 alkenyl. R2 is, for example, OCH=CH2 or OCH2CH=CH2.

[0049] According to yet another specific embodiment of formula I, R2 is O-alkynyl C2-C6, particularly alkynyl C2-C6, particularly alkynyl C2C4, more specifically alkynyl C2-C3. R2 is, for example, O-CH2-CECH.

[0050] According to yet another embodiment of formula I, R2 is a C3-C6 cycloalkyl group, particularly cyclopropyl or cyclobutyl.

[0051] According to yet another specific embodiment of formula I, R2 is C1-C6 S-alkyl, particularly C1-C4 alkyl, more specifically C1-C2 alkoxy. R2 is, for example, SCH3 or SCH2CH3.

[0052] According to yet another specific embodiment of formula I, R2 is C1-C6 S-alkyl. Petition 870250083202, dated 09 / 16 / 2025, pp. 165 / 317 14 / 159

[0053] According to yet another specific embodiment of formula I, R2 is S-alkenyl C2-C6, particularly alkenyl C2-C4, more specifically alkenyl C2-C3. R2 is, for example, SCH=CH2 or SCH2CH=CH2.

[0054] According to yet another specific embodiment of formula I, R2 is S-alkyl C2-C6, particularly alkyl C2-C6, particularly alkyl C2C4, more specifically alkyl C2-C3. R2 is, for example, S-CH2-CΞCH.

[0055] Particularly preferred embodiments of R2 according to the present invention are found in Table 1 below, wherein each of the rows P2-1 to P2-21 corresponds to a specific embodiment of the present invention and P2-1 to P2-21 are also, in any combination thereof, a preferred embodiment of the present invention. The point of connection to the carbon atom, to which R2 is attached, is marked with “#” in the figures. Table 1 No. R2 P2-1 CH3 P2-2 CH2F P2-3 CHF2 P2-4 CF3 P2-5 C2H5 P2-6 CH(CH3)2 P2-7 CH2CH2CH3 P2-8 CH=CH2 P2-9 CH2CH=CH2 P2-10 ΟΞΟΗ P2-11 ΟΚΌΞΟΗ P2-12 OCF3 P2-13 OCH3 P2-14 OCHF2 P2-15 OC2H5 P2-16 CN P2-17 F P2-18 Cl P2-19 Br P2-20 #—<] P2-21 #— <O

[0056] According to a realization of formula I, R3 is selected at Petition 870250083202, dated 09 / 16 / 2025, pp. 166 / 317 15 / 159 starting from the group consisting of C1-C6 alkyl, C1-C6 halogen alkyl and C3-C6 cycloalkyl, particularly CH3, C2H5, CF3, CH2F, CHF2, cyclopropyl or cyclobutyl, more specifically CH3, CH2F, CF2H, CF3, cyclopropyl, cyclobutyl and, more preferably, CH3 or CF2H.

[0057] According to yet another embodiment of formula I, R3 is C1C6 alkyl, particularly C1-C4 alkyl, such as CH3 or C2H5, particularly CH3 or CH2CH3.

[0058] According to yet another embodiment of formula I, R3 is a C1-C6 alkyl halogen, particularly a C1-C4 alkyl halogen, such as CF3, FCH2, F2CH or CF3CH2.

[0059] According to yet another embodiment of formula I, R3 is C2-C6 alkenyl, particularly C2-C4 alkenyl, such as CH=CH2, C(CH3)=CH2 or CH2CH=CH2.

[0060] According to yet another embodiment of formula I, R3 is C2-C6 alkynyl or C2-C6 alkynyl halogen, particularly C2-C4 alkynyl or C2-C4 alkynyl halogen, such as CΞCH, CH2CΞCH, CECCI, CH2CΞCCl or CCIaCECCI.

[0061] According to another specific embodiment of formula I, R3 is C1-C6 alkyl, particularly C1-C4 alkyl, more specifically C1-C2 alkoxy. R3 is, for example, OCH3 or OCH2CH3.

[0062] According to another specific embodiment of formula I, R3 is C2-C6 alkenyl, particularly C2-C4 alkenyl, more specifically C2-C3 alkenyl. R3 is, for example, OCH=CH2 or OCH2CH=CH2.

[0063] According to another specific embodiment of formula I, R3 is O-alkynyl C2-C6, particularly alkynyl C2-C6, particularly alkynyl C2-C4, more specifically alkynyl C2-C3. R3 is, for example, O-CH2-CECH.

[0064] According to another specific embodiment of formula I, R3 is a C1-C6 alkyl halogen, particularly OCF3, OCCI3, OFCH2, OCICH2, OF2CH, OCl2CH, OCF3CH2, OCCl3CH2 or OCF2CHF2, more specifically OCF3, Petition 870250083202, dated 09 / 16 / 2025, page 167 / 317 16 / 159 OF2CH or OFCH2.

[0065] According to yet another embodiment of formula I, R3 is a C3-C6 cycloalkyl group, particularly cyclopropyl or cyclobutyl.

[0066] According to another specific embodiment of formula I, R3 is C1-C6 alkyl, particularly C1-C4 alkyl, more specifically C1-C2 alkoxy. R2 is, for example, SCH3 or SCH2CH3.

[0067] According to another specific embodiment of formula I, R3 is C1-C6 alkyl.

[0068] According to another specific embodiment of formula I, R3 is C2-C6 salkenyl, particularly C2-C4 alkenyl, more specifically C2-C3 alkenyl. R2 is, for example, SCH=CH2 or SCH2CH=CH2.

[0069] According to another specific embodiment of formula I, R3 is C2-C6 salquinyl, particularly C2-C6 alkynyl, particularly C2-C4 alkynyl, more specifically C2-C3 alkynyl. R2 is, for example, S-CH2-CΞCH.

[0070] Particularly preferred embodiments of R3 according to the present invention are found in Table 2 below, wherein each of the rows P3-1 to P3-17 corresponds to a specific embodiment of the present invention and P3-1 to P3-17 are also, in any combination thereof, a preferred embodiment of the present invention. The point of connection to the carbon atom, to which R3 is attached, is marked with “#” in the figures. Table 2 No. R3 P3-1 CH3 P3-2 CH2F P3-3 CHF2 P3-4 CF3 P3-5 C2H5 P3-6 CH(CH3)2 P3-7 CH2CH2CH3 P3-8 CH=CH2 P3-9 CH2CH=CH2 P3-10 CECH Petition 870250083202, dated 09 / 16 / 2025, pp. 168 / 317 17 / 159 No. R3 P3-11 ΟΙ-^Ξ^ P3-12 OCHF3 P3-13 OCH3 P3-14 OCHF2 P3-15 OC2H5 P3-16 #— P3-17

[0071] According to one embodiment of the compound of formula I, R4 is selected independently in each case from H, halogen, CN, C1-C4 alkyl or halogen C1-C4 alkyl; preferably, R4 is selected independently in each case from H, C1-C4 alkyl or halogen C1-C4 alkyl; more preferably, R4 is selected independently in each case from H, C1-C4 alkyl and, most preferably, R4 is, in each case, H.

[0072] According to an embodiment of the compound of formula I, R5 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R5a substituents; wherein each R5a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl.

[0073] According to one embodiment of the compound of formula I, R5 is selected independently in each case from C1-C6 alkyl (embodiment 5.1), C1-C6 halogen alkyl (embodiment 5.2), C1-C6 alkyl O-alkyl C1-C6 (embodiment 5.3), phenyl or CH2-phenyl (embodiment 5.4), wherein phenyl and CH2 Petition 870250083202, dated 09 / 16 / 2025, pp. 169 / 317 18 / 159 phenyl groups are either unsubstituted or substituted by one or two halogens.

[0074] According to another embodiment of the compound of formula I, R5 is CH3 or CF3.

[0075] According to another embodiment of the compound of formula I, R5 is CH3.

[0076] According to another embodiment of the compound of formula I, R5 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3 or CH2-O-CH3.

[0077] According to another embodiment of the compound of formula I, R5 is CH=CH2 or CH2CH=CH2.

[0078] According to another embodiment of the compound of formula I, R5 is phenyl, 2-F-phenyl, 4-F-phenyl, 2,4-F2-phenyl, 2-Cl-phenyl, 4-Cl-phenyl, CH2-phenyl, CH2-2-F-phenyl or CH2-4-F-phenyl.

[0079] According to one embodiment of the compound of formula I, R6 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R6a substituents; and each R6a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl.

[0080] According to an embodiment of the compound of formula I, R6 is selected, independently in each case, from C1-C6 alkyl (embodiment 6.1), C1-C6 O-phenyl alkyl (embodiment 6.2) and C1-C6 O-alkyl C1-C6 alkyl (embodiment 6.3).

[0081] According to another embodiment of the compound of formula I, R6 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, Petition 870250083202, dated 09 / 16 / 2025, pp. 170 / 317 19 / 159 CH2-CH(CH3)-C(CH3)3, CH2-CH2-C(CH3)3, CH2-O-CH3, CH2-O-(CH3)3, CH2-Ophenyl, CH=CH2, CH2CH=CH2 or CH2-phenyl.

[0082] According to another embodiment of the compound of formula I, R5 and R6 together with the C atoms to which they are attached form a C3C6 cycloalkyl or saturated heterocycle with 3 to 6 members containing 1, 2 or 3 heteroatoms of the group consisting of O and S, wherein the cycloalkyl or heterocycle may be unsubstituted or substituted by halogen, C1C6 alkyl or C1-C6 halogen alkyl.

[0083] According to another embodiment of the compound of formula I, R5 and R6 form C3-C6 cycloalkyl (embodiment 6.4).

[0084] According to another embodiment of the compound of formula I, R5 and R6 form a saturated heterocycle with 3 to 6 members containing 1, 2 or 3 heteroatoms from the group consisting of O and S.

[0085] According to another embodiment of the compound of formula I, R5 and R6 together form a group (=O) (emphasis 6.5).

[0086] Preferred embodiments of R5 and R6 according to the present invention are found in Table 3 below, wherein each of the rows P5-1 to P5-19 corresponds to a specific embodiment of the present invention and P5-1 to P5-19 are also, in any combination thereof, a preferred embodiment of the present invention. The point of connection to the carbon atom, to which R5 and R6 are attached, is marked with “#” in the figures. Table 3 No. R5 R6 P5-1 •-A # P5-2 # P5-3 #-33 # Petition 870250083202, dated 09 / 16 / 2025, pp. 171 / 317 20 / 159 # Petition 870250083202, dated 09 / 16 / 2025, p. 172 / 317 21 / 159 No. R5 R6 P5-18 r^O # P5-19 =O

[0087] According to an embodiment of the compound of formula I, R7 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R7a substituents; wherein each R7a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl.

[0088] According to one embodiment of the compound of formula I, R7 is selected independently in each case from C1-C6 alkyl (embodiment 7.1), C1-C6 halogen alkyl (embodiment 7.2), C1-C6 O-alkyl C1-C6 alkyl (embodiment 7.3), phenyl and CH2-phenyl (embodiment 7.4), wherein phenyl and CH2-phenyl are unsubstituted or substituted by one or two halogens.

[0089] According to another embodiment of the compound of formula I, R7 is CH3 or CF3.

[0090] According to another embodiment of the compound of formula I, R7e CH3.

[0091] According to another embodiment of the compound of formula I, R7 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-O-CH3, CH=CH2 or CH2CH=CH2.

[0092] According to another embodiment of the compound of formula I, R7 is phenyl, 2-F-phenyl, 4-F-phenyl, 2,4-F2-phenyl, 2-Cl-phenyl, 4-Cl-phenyl, CH2-phenyl, CH2-2-F-phenyl or CH2-4-F-phenyl.

[0093] According to a realization of the compound of formula I, R8 is Petition 870250083202, dated 09 / 16 / 2025, pp. 173 / 317 22 / 159 selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R8a substituents; and each R8a is independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl.

[0094] According to an embodiment of the compound of formula I, R8 is selected, independently in each case, from C1-C6 alkyl (embodiment 8.1), C1-C6 O-phenyl alkyl (embodiment 8.2) or C1-C6 O-alkyl C1-C6 alkyl (embodiment 8.3).

[0095] According to another embodiment of the compound of formula I, R8 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-CH(CH3)-C(CH3)3, CH2-CH2-C(CH3)3, CH2-O-CH3, CH2-O-(CH3)3, CH2-Ophenyl, CH=CH2, CH2CH=CH2 or CH2-phenyl.

[0096] According to another embodiment of the compound of formula I, R7 and R8 form, together with the C atoms to which they are attached, a C3C6 cycloalkyl or a saturated heterocycle with 3 to 6 members containing 1, 2 or 3 heteroatoms of the group consisting of O and S, wherein the cycloalkyl or heterocycle may be unsubstituted or substituted by halogen, C1C6 alkyl or C1-C6 halogen alkyl.

[0097] According to another embodiment of the compound of formula I, R7 and R8 form C3-C6 cycloalkyl (embodiment 8.4).

[0098] According to another embodiment of the compound of formula I, R7 and R8 form a saturated heterocycle with 3 to 6 members containing 1, 2 or 3 heteroatoms from the group consisting of O and S.

[0099] Preferred realizations of R7 and R8 according to this Petition 870250083202, dated 09 / 16 / 2025, pp. 174 / 317 23 / 159 inventions are found in Table 4 below, where each of the rows P7-1 to P7-19 corresponds to a specific embodiment of the present invention and P7-1 to P7-19 are also, in any combination thereof, a preferred embodiment of the present invention. The point of connection to the carbon atom, to which R7 and R8 are attached, is marked with “#” in the figures. Table 4 No. R7 R8 P7-1 •-A # P7-2 # P7-3 #-33 # P7-4 # P7-5 0 #- / A # P7-6 0 # P7-7 °—| —I # P7-8 # P7-9 feet JX P7-10 ttd__ / -- P7-11 # P7-12 Oy # Petition 870250083202, dated 09 / 16 / 2025, pp. 175 / 317 24 / 159 N° R7 R8 P7-13 # r° P7-14 # Γ°\ P7-15 *-L·) * ¥ P7-16 # o P7-17 # I^Q P7-18 #— # P7-19 =O

[00100] According to an embodiment of the compound of formula I, X is selected, independently in each case, from halogen (embodiment X.1), CN, C1-C6 alkyl (embodiment X.2), halogen C1-C6 alkyl (embodiment X.3), O-alkyl C1-C6 (embodiment X.4) and halogen O-alkyl C1-C6 (embodiment X.5).

[00101] According to one embodiment of the compound of formula I, X is selected, independently in each case, from halogen and C1-C6 Oalkyl.

[00102] According to one embodiment of the compound of formula I, X is selected, independently in each case, from F or Cl.

[00103] According to one embodiment of the compound of formula I, X is a C3-C6 cycloalkyl group.

[00104] According to a realization of the compound of formula I, n is 0. Petition 870250083202, dated 09 / 16 / 2025, page 176 / 317 25 / 159

[00105] According to a realization of the compound of formula I, n is 1. It's 2. below:

[00106] According to a realization of the compound of formula I, n

[00107] According to one realization, Xn is conformally defined and X is selected from F, Cl, I, CH3, cyclopropyl, CH=CH2, CΞCH, OCH3, OCHF2, CF3, CHF2, CH2CH3, CN and OPh.

[00108] According to one realization, Xn is defined as follows: and X is F.

[00109] According to one realization, Xn is defined as follows: _6 7rYYr8 YY YY rY^N-^R and X is selected from F, Cl, I, CH3, cyclopropyl, CH=CH2, Petition 870250083202, dated 09 / 16 / 2025, pp. 177 / 317 26 / 159 ΟΞΟΗ, OCH3, OCHF2, CF3, CHF2, CH2CH3, CN and OPh.

[00110] According to one realization, Xn is defined as follows: rA'r· N R R2 R 6 and X is F.

[00111] According to one realization, n is 0.

[00112] According to the present invention, therefore, the compound of formula I having a chiral center can be used in the form of: - racemic mixture of the (R) enantiomer and the (S) enantiomer; - mixture with any other proportion of the (R) enantiomer and the (S) enantiomer; - pure (R) enantiomer; or - pure (S) enantiomer.

[00113] According to a specific embodiment, the compound of formula I is provided and used as enantiomer (R) with enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%.

[00114] According to a specific embodiment, the compound of formula I is provided and used as enantiomer (S) with an enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, preferably higher, Petition 870250083202, dated 09 / 16 / 2025, pp. 178 / 317 27 / 159 at least 99%.

[00115] According to the present invention, therefore, the compound of formula I with two chiral centers can be used in the form of: - racemic mixture of the (R,R) enantiomer and the (S,S) enantiomer; - mixture with any other proportion of the (R,R) enantiomer and the (S,S) enantiomer; - pure (R,R) enantiomer; or - pure (S,S) enantiomer.

[00116] According to a specific embodiment, the compound of formula I is provided and used as an enantiomer (R,R) with an enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%.

[00117] According to a specific embodiment, the compound of formula I is provided and used as an enantiomer (S,S) with an enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%.

[00118] According to the present invention, therefore, the compound of formula I with two chiral centers can be used in the form of: - racemic mixture of the (R,S) enantiomer and the (S,R) enantiomer; - mixture with any other proportion of the (R,S) enantiomer and the (S,R) enantiomer; - pure (R,S) enantiomer; or Petition 870250083202, dated 09 / 16 / 2025, pp. 179 / 317 28 / 159 - pure (S,R) enantiomer.

[00119] According to a specific embodiment, the compound of formula I is provided and used as an enantiomer (R,S) with an enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%.

[00120] According to a specific embodiment, the compound of formula I is provided and used as an enantiomer (S,R) with an enantiomeric excess (ee) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, most preferably at least 98% and, most preferably, at least 99%.

[00121] According to the present invention, therefore, the compound of formula I with two chiral centers can be used in the form of a mixture with any proportion of the diastereomer (R,S) and the diastereomer (S,S).

[00122] According to a specific embodiment, the compound of formula I is provided and used as a diastereomer (R,S) with a diastereomeric excess (de) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%.

[00123] According to a specific embodiment, the compound of formula I is provided and used as a diastereomer (S,S) with a diastereomeric excess (de) of at least 40%, such as at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, even more preferably at least 98% and, most preferably, at least 99%. Petition 870250083202, dated 09 / 16 / 2025, pp. 180 / 317 29 / 159

[00124] This applies to mixtures with any other proportion of a mixture A (composed of any proportion of (R,R) enantiomer and (S,S) enantiomer) and a mixture B (composed of any proportion of (R,S) enantiomer and (S,R) enantiomer).

[00125] This also applies to the compound of formula I with three, four and five chiral centers.

[00126] In other respects, the present invention relates to embodiments E. 1 to E. 275 listed in Table 5 below, which represent preferred combinations of embodiments that are defined above for each of the variables R2, R3 and X (represented by embodiments X. 1 to X. 6), where n in the compounds of formula I is as defined below: N' R Xn Table 5 Realization X n R2 R3 E.1 (X.1) 0, 1 or 2 C1-C6 alkyl C1-C6 alkyl E.2 (X.2) 0, 1 or 2 C1-C6 alkyl C1-C6 alkyl E.3 (X.3) 0, 1 or 2 C1-C6 alkyl C1-C6 alkyl E.4 (X.4) 0, 1 or 2 C1-C6 alkyl C1-C6 alkyl E.5 (X.5) 0, 1 or 2 C1-C6 alkyl C1-C6 alkyl E.6 (X.1) 0, 1 or 2 halogen C1-C6 alkyl E.7 (X.2) 0, 1 or 2 halogen C1-C6 alkyl E.8 (X.3) 0, 1 or 2 halogen C1-C6 alkyl E.9 (X.4) 0, 1 or 2 halogen C1-C6 alkyl E.10 (X.5) 0, 1 or 2 halogen C1-C6 alkyl E.11 (X.1) 0, 1 or 2 halogen C1-C6 alkyl C1-C6 alkyl E.12 (X.2) 0, 1 or 2 halogen C1-C6 alkyl C1-C6 alkyl E.13 (X.3) 0, 1 or 2 halogen C1-C6 alkyl C1-C6 alkyl E.14 (X.4) 0, 1 or 2 halogen C1-C6 alkyl C1-C6 alkyl E.15 (X.5) 0, 1 or 2 halogen C1-C6 alkyl C1-C6 alkyl E.16 (X.1) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl Petition 870250083202, dated 09 / 16 / 2025, pp. 181 / 317 30 / 159 Realization X n R2 R3 E.17 (X.2) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl E.18 (X.3) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl E.19 (X.4) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl E.20 (X.5) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl E.21 (X.1) 0, 1 or 2 C2-C6 alkenyl halogen C1-C6 alkyl E.22 (X.2) 0, 1 or 2 C2-C6 alkenyl halogen C1-C6 alkyl E.23 (X.3) 0, 1 or 2 C2-C6 alkenyl halogen C1-C6 alkyl E.24 (X.4) 0, 1 or 2 halogen C2-C6 alkenyl C1-C6 alkyl E.25 (X.5) 0, 1 or 2 halogen C2-C6 alkenyl C1-C6 alkyl E.26 (X.1) 0, 1 or 2 C2-C6 alkynyl C1-C6 alkyl E.27 (X.2) 0, 1 or 2 C2-C6 alkynyl C1-C6 alkyl E.28 (X.3) 0, 1 or 2 C2-C6 alkynyl C1-C6 alkyl E.29 (X.4) 0, 1 or 2 C2-C6 alkynyl C1-C6 alkyl E.30 (X.5) 0, 1 or 2 C2-C6 alkynyl C1-C6 alkyl E.31 (X.1) 0, 1 or 2 halogen alkynyl C2-C6 alkyl C1-C6 E.32 (X.2) 0, 1 or 2 halogen alkynyl C2-C6 alkyl C1-C6 E.33 (X.3) 0, 1 or 2 halogen alkynyl C2-C6 alkyl C1-C6 E.34 (X.4) 0, 1 or 2 halogen alkynyl C2-C6 alkyl C1-C6 E.35 (X.5) 0, 1 or 2 halogen alkynyl C2-C6 alkyl C1-C6 E.36 (X.1) 0, 1 or 2 O-alkyl C1-C6 alkyl C1-C6 E.37 (X.2) 0, 1 or 2 O-alkyl C1-C6 alkyl C1-C6 E.38 (X.3) 0, 1 or 2 O-alkyl C1-C6 alkyl C1-C6 E.39 (X.4) 0, 1 or 2 O-alkyl C1-C6 alkyl C1-C6 E.40 (X.5) 0, 1 or 2 O-alkyl C1-C6 alkyl C1-C6 E.41 (X.1) 0, 1 or 2 O-alkenyl C2-C6 alkyl C1-C6 E.42 (X.2) 0, 1 or 2 O-alkenyl C2-C6 alkyl C1-C6 E.43 (X.3) 0, 1 or 2 O-alkenyl C2-C6 alkyl C1-C6 E.44 (X.4) 0, 1 or 2 O-alkenyl C2-C6 alkyl C1-C6 E.45 (X.5) 0, 1 or 2 O-alkenyl C2-C6 alkyl C1-C6 E.46 (X.1) 0, 1 or 2 O-alkynyl C2-C6 alkyl C1-C6 E.47 (X.2) 0, 1 or 2 O-alkynyl C2-C6 alkyl C1-C6 E.48 (X.3) 0, 1 or 2 O-alkynyl C2-C6 alkyl C1-C6 E.49 (X.4) 0, 1 or 2 O-alkynyl C2-C6 alkyl C1-C6 E.50 (X.5) 0, 1 or 2 O-alkynyl C2-C6 alkyl C1-C6 E.51 (X.1) 0, 1 or 2 cycloalkyl C3-C6 alkyl C1-C6 E.52 (X.2) 0, 1 or 2 cycloalkyl C3-C6 alkyl C1-C6 E.53 (X.3) 0, 1 or 2 cycloalkyl C3-C6 alkyl C1-C6. Petition 870250083202, dated 09 / 16 / 2025, page 182 / 317 31 / 159 Realization X n R2 R3 E.54 (X.4) 0, 1 or 2 C3-C6 cycloalkyl C1-C6 alkyl E.55 (X.5) 0, 1 or 2 C3-C6 cycloalkyl C1-C6 alkyl E.56 (X.1) 0, 1 or 2 C1-C6 alkyl halogen C1-C6 alkyl E.57 (X.2) 0, 1 or 2 C1-C6 alkyl halogen C1-C6 alkyl E.58 (X.3) 0, 1 or 2 C1-C6 alkyl halogen C1-C6 alkyl E.59 (X.4) 0, 1 or 2 C1-C6 alkyl halogen C1-C6 alkyl E.60 (X.5) 0, 1 or 2 C1-C6 alkyl halogen alkyl C1-C6 E.61 (X.1) 0, 1 or 2 halogen halogen alkyl C1-C6 E.62 (X.2) 0, 1 or 2 halogen halogen alkyl C1-C6 E.63 (X.3) 0, 1 or 2 halogen halogen alkyl C1-C6 E.64 (X.4) 0, 1 or 2 halogen halogen alkyl C1-C6 E.65 (X.5) 0, 1 or 2 halogen halogen alkyl C1-C6 E.66 (X.1) 0, 1 or 2 halogen alkyl C1-C6 halogen alkyl C1-C6 E.67 (X.2) 0, 1 or 2 halogen alkyl C1-C6 halogen alkyl C1-C6 E.68 (X.3) 0, 1 or 2 halogen alkyl C1-C6 halogen alkyl C1-C6 E.69 (X.4) 0, 1 or 2 halogen alkyl C1-C6 halogen alkyl C1-C6 E.70 (X.5) 0, 1 or 2 C1-C6 alkyl halogen C1-C6 alkyl halogen E.71 (X.1) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl halogen E.72 (X.2) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl halogen E.73 (X.3) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl halogen E.74 (X.4) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl halogen E.75 (X.5) 0, 1 or 2 C2-C6 alkenyl C1-C6 alkyl halogen E.76 (X.1) 0, 1 or 2 C2-C6 alkenyl halogen alkyl halogen C1-C6 E.77 (X.2) 0, 1 or 2 halogen alkenyl C2-C6 halogen alkyl C1-C6 E.78 (X.3) 0, 1 or 2 halogen alkenyl C2-C6 halogen alkyl C1-C6 E.79 (X.4) 0, 1 or 2 halogen alkenyl C2-C6 halogen alkyl C1-C6 E.80 (X.5) 0, 1 or 2 halogen alkenyl C2-C6 halogen alkyl C1-C6 E.81 (X.1) 0, 1 or 2 alkynyl C2-C6 halogen alkyl C1-C6 E.82 (X.2) 0, 1 or 2 alkynyl C2-C6 halogen alkyl C1-C6 E.83 (X.3) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl E.84 (X.4) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl E.85 (X.5) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen E.86 (X.1) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen E.87 (X.2) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen E.88 (X.3) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen E.89 (X.4) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen E.90 (X.5) 0, 1 or 2 C2-C6 alkynyl halogen C1-C6 alkyl halogen. Petition 870250083202, dated 09 / 16 / 2025, pp. 183 / 317 32 / 159 Realization X n R2 R3 E.91 (X.1) 0, 1 or 2 O-alkyl C1-C6 halogen alkyl C1-C6 E.92 (X.2) 0, 1 or 2 O-alkyl C1-C6 halogen alkyl C1-C6 E.93 (X.3) 0, 1 or 2 O-alkyl C1-C6 halogen alkyl C1-C6 E.94 (X.4) 0, 1 or 2 O-alkyl C1-C6 halogen alkyl C1-C6 E.95 (X.5) 0, 1 or 2 O-alkyl C1-C6 halogen alkyl C1-C6 E.96 (X.1) 0, 1 or 2 O-alkenyl C2-C6 halogen alkyl C1-C6 E.97 (X.2) 0, 1 or 2 O-alkenyl C2-C6 halogen alkyl C1-C6 E.98 (X.3) 0, 1 or 2 O-alkenyl C2-C6 halogen alkyl C1-C6 E.99 (X.4) 0, 1 or 2 O-alkenyl C2-C6 halogen alkyl C1-C6 E.100 (X.5) 0, 1 or 2 O-alkenyl C2-C6 halogen alkyl C1-C6 E.101 (X.1) 0, 1 or 2 O-alkynyl C2-C6 halogen alkyl C1-C6 E.102 (X.2) 0, 1 or 2 O-alkynyl C2-C6 halogen alkyl C1-C6 E.103 (X.3) 0, 1 or 2 O-alkynyl C2-C6 halogen alkyl C1-C6 E.104 (X.4) 0, 1 or 2 O-alkynyl C2-C6 halogen alkyl C1-C6 E.105 (X.5) 0, 1 or 2 O-alkynyl C2-C6 halogen alkyl C1-C6 E.106 (X.1) 0, 1 or 2 cycloalkyl C3-C6 halogen alkyl C1-C6 E.107 (X.2) 0, 1 or 2 cycloalkyl C3-C6 halogen alkyl C1-C6 E.108 (X.3) 0, 1 or 2 cycloalkyl C3-C6 halogen alkyl C1-C6 E.109 (X.4) 0, 1 or 2 cycloalkyl C3-C6 halogen alkyl C1-C6 E.110 (X.5) 0, 1 or 2 cycloalkyl C3-C6 halogen alkyl C1-C6 E.111 (X.1) 0, 1 or 2 alkyl C1-C6 O-alkyl C1-C6 E.112 (X.2) 0, 1 or 2 alkyl C1-C6 O-alkyl C1-C6 E.113 (X.3) 0, 1 or 2 C1-C6 alkyl C1-C6 o-alkyl E.114 (X.4) 0, 1 or 2 C1-C6 alkyl C1-C6 o-alkyl E.115 (X.5) 0, 1 or 2 C1-C6 alkyl C1-C6 o-alkyl E.116 (X.1) 0, 1 or 2 halogen C1-C6 o-alkyl E.117 (X.2) 0, 1 or 2 halogen C1-C6 o-alkyl E.118 (X.3) 0, 1 or 2 halogen C1-C6 o-alkyl E.119 (X.4) 0, 1 or 2 halogen C1-C6 o-alkyl E.120 (X.5) 0, 1 or 2 halogen O-alkyl C1-C6 E.121 (X.1) 0, 1 or 2 halogen alkyl C1-C6 O-alkyl C1-C6 E.122 (X.2) 0, 1 or 2 halogen alkyl C1-C6 O-alkyl C1-C6 E.123 (X.3) 0, 1 or 2 halogen alkyl C1-C6 O-alkyl C1-C6 E.124 (X.4) 0, 1 or 2 halogen alkyl C1-C6 O-alkyl C1-C6 E.125 (X.5) 0, 1 or 2 halogen alkyl C1-C6 O-alkyl C1-C6 E.126 (X.1) 0, 1 or 2 alkenyl C2-C6 O-alkyl C1-C6 E.127 (X.2) 0, 1 or 2 alkenyl C2-C6 O-alkyl C1-C6. Petition 870250083202, dated 09 / 16 / 2025, pp. 184 / 317 33 / 159 Realization X n R2 R3 E.128 (X.3) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl E.129 (X.4) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl E.130 (X.5) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl E.131 (X.1) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl halogen E.132 (X.2) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl halogen E.133 (X.3) 0, 1 or 2 C2-C6 alkenyl C1-C6 O-alkyl halogen E.134 (X.4) 0, 1 or 2-halogen alkenyl C2-C6 O-alkyl C1-C6 E.135 (X.5) 0, 1 or 2-halogen alkenyl C2-C6 O-alkyl C1-C6 E.136 (X.1) 0, 1 or 2-halogen alkenyl C2-C6 O-alkyl C1-C6 E.137 (X.2) 0, 1 or 2-halkynyl C2-C6 O-alkyl C1-C6 E.138 (X.3) 0, 1 or 2-halkynyl C2-C6 O-alkyl C1-C6 E.139 (X.4) 0, 1 or 2-halkynyl C2-C6 O-alkyl C1-C6 E.140 (X.5) 0, 1 or 2-halkynyl C2-C6 O-alkyl C1-C6 E.141 (X.1) 0, 1 or 2 halogen alkynyl C2-C6 O-alkyl C1-C6 E.142 (X.2) 0, 1 or 2 halogen alkynyl C2-C6 O-alkyl C1-C6 E.143 (X.3) 0, 1 or 2 halogen alkynyl C2-C6 O-alkyl C1-C6 E.144 (X.4) 0, 1 or 2 halogen alkynyl C2-C6 O-alkyl C1-C6 E.145 (X.5) 0, 1 or 2 halogen alkynyl C2-C6 O-alkyl C1-C6 E.146 (X.1) 0, 1 or 2 O-alkyl C1-C6 O-alkyl C1-C6 E.147 (X.2) 0, 1 or 2 O-alkyl C1-C6 O-alkyl C1-C6 E.148 (X.3) 0, 1 or 2 O-alkyl C1-C6 O-alkyl C1-C6 E.149 (X.4) 0, 1 or 2 O-alkyl C1-C6 O-alkyl C1-C6 E.150 (X.5) 0, 1 or 2 O-alkyl C1-C6 O-alkyl C1-C6 E.151 (X.1) 0, 1 or 2 O-alkenyl C2-C6 O-alkyl C1-C6 E.152 (X.2) 0, 1 or 2 O-alkenyl C2-C6 O-alkyl C1-C6 E.153 (X.3) 0, 1 or 2 O-alkenyl C2-C6 O-alkyl C1-C6 E.154 (X.4) 0, 1 or 2 O-alkenyl C2-C6 O-alkyl C1-C6 E.155 (X.5) 0, 1 or 2 O-alkenyl C2-C6 O-alkyl C1-C6 E.156 (X.1) 0, 1 or 2 O-alkynyl C2-C6 O-alkyl C1-C6 E.157 (X.2) 0, 1 or 2 O-alkynyl C2-C6 O-alkyl C1-C6 E.158 (X.3) 0, 1 or 2 O-alkynyl C2-C6 O-alkyl C1-C6 E.159 (X.4) 0, 1 or 2 O-alkynyl C2-C6 O-alkyl C1-C6 E.160 (X.5) 0, 1 or 2 O-alkynyl C2-C6 O-alkyl C1-C6 E.161 (X.1) 0, 1 or 2 cycloalkyl C3-C6 O-alkyl C1-C6 E.162 (X.2) 0, 1 or 2 cycloalkyl C3-C6 O-alkyl C1-C6 E.163 (X.3) 0, 1 or 2 cycloalkyl C3-C6 O-alkyl C1-C6 E.164 (X.4) 0, 1 or 2 cycloalkyl C3-C6 O-alkyl C1-C6. Petition 870250083202, dated 09 / 16 / 2025, pp. 185 / 317 34 / 159 Realization X n R2 R3 E.165 (X.5) 0, 1 or 2 C3-C6 cycloalkyl O-alkyl C1-C6 E.166 (X.1) 0, 1 or 2 C1-C6 alkyl C3-C6 cycloalkyl E.167 (X.2) 0, 1 or 2 C1-C6 alkyl C3-C6 cycloalkyl E.168 (X.3) 0, 1 or 2 C1-C6 alkyl C3-C6 cycloalkyl E.169 (X.4) 0, 1 or 2 C1-C6 alkyl C3-C6 cycloalkyl E.170 (X.5) 0, 1 or 2 C1-C6 alkyl C3-C6 cycloalkyl E.171 (X.1) 0, 1 or 2 halogen C3-C6 cycloalkyl E.172 (X.2) 0, 1 or 2 halogen cycloalkyl C3-C6 E.173 (X.3) 0, 1 or 2 halogen cycloalkyl C3-C6 E.174 (X.4) 0, 1 or 2 halogen cycloalkyl C3-C6 E.175 (X.5) 0, 1 or 2 halogen cycloalkyl C3-C6 E.176 (X.1) 0, 1 or 2 halogen alkyl C1-C6 cycloalkyl C3-C6 E.177 (X.2) 0, 1 or 2 halogen alkyl C1-C6 cycloalkyl C3-C6 E.178 (X.3) 0, 1 or 2 halogen alkyl C1-C6 cycloalkyl C3-C6 E.179 (X.4) 0, 1 or 2 halogen alkyl C1-C6 cycloalkyl C3-C6 E.180 (X.5) 0, 1 or 2 halogen alkyl C1-C6 cycloalkyl C3-C6 E.181 (X.1) 0, 1 or 2 alkenyl C2-C6 cycloalkyl C3-C6 E.182 (X.2) 0, 1 or 2 alkenyl C2-C6 cycloalkyl C3-C6 E.183 (X.3) 0, 1 or 2 alkenyl C2-C6 cycloalkyl C3-C6 E.184 (X.4) 0, 1 or 2 alkenyl C2-C6 cycloalkyl C3-C6 E.185 (X.5) 0, 1 or 2 alkenyl C2-C6 cycloalkyl C3-C6 E.186 (X.1) 0, 1 or 2 halogen alkenyl C2-C6 cycloalkyl C3-C6 E.187 (X.2) 0, 1 or 2 halogen alkenyl C2-C6 cycloalkyl C3-C6 E.188 (X.3) 0, 1 or 2 halogen alkenyl C2-C6 cycloalkyl C3-C6 E.189 (X.4) 0, 1 or 2 halogen C2-C6 alkenyl C3-C6 cycloalkyl E.190 (X.5) 0, 1 or 2 halogen C2-C6 alkenyl C3-C6 cycloalkyl E.191 (X.1) 0, 1 or 2 alkynyl C2-C6 cycloalkyl C3-C6 E.192 (X.2) 0, 1 or 2 alkynyl C2-C6 cycloalkyl C3-C6 E.193 (X.3) 0, 1 or 2 alkynyl C2-C6 cycloalkyl C3-C6 E.194 (X.4) 0, 1 or 2 alkynyl C2-C6 cycloalkyl C3-C6 E.195 (X.5) 0, 1 or 2 alkynyl C2-C6 cycloalkyl C3-C6 E.196 (X.1) 0, 1 or 2 halogen alkynyl C2-C6 cycloalkyl C3-C6 E.197 (X.2) 0, 1 or 2 halogen alkynyl C2-C6 cycloalkyl C3-C6 E.198 (X.3) 0, 1 or 2 halogen alkynyl C2-C6 cycloalkyl C3-C6 E.199 (X.4) 0, 1 or 2 halogen alkynyl C2-C6 cycloalkyl C3-C6 E.200 (X.5) 0, 1 or 2 halogen alkynyl C2-C6 cycloalkyl C3-C6 E.201 (X.1) 0, 1 or 2 O-alkyl C1-C6 cycloalkyl C3-C6. Petition 870250083202, dated 09 / 16 / 2025, pp. 186 / 317 35 / 159 Embodiment X n R2 R3 E.202 (X.2) 0, 1 or 2 O-alkyl C1-C6 cycloalkyl C3-C6 E.203 (X.3) 0, 1 or 2 O-alkyl C1-C6 cycloalkyl C3-C6 E.204 (X.4) 0, 1 or 2 O-alkyl C1-C6 cycloalkyl C3-C6 E.205 (X.5) 0, 1 or 2 O-alkyl C1-C6 cycloalkyl C3-C6 E.206 (X.1) 0, 1 or 2 O-alkenyl C2-C6 cycloalkyl C3-C6 E.207 (X.2) 0, 1 or 2 O-alkenyl C2-C6 cycloalkyl C3-C6 E.208 (X.3) 0, 1 or 2 O-alkenyl C2-C6 cycloalkyl C3-C6 E.209 (X.4) 0, 1 or 2 O-alkenyl C2-C6 cycloalkyl C3-C6 E.210 (X.5) 0, 1 or 2 O-alkenyl C2-C6 cycloalkyl C3-C6 E.211 (X.1) 0, 1 or 2 O-alkynyl C2-C6 cycloalkyl C3-C6 E.212 (X.2) 0, 1 or 2 O-alkynyl C2-C6 cycloalkyl C3-C6 E.213 (X.3) 0, 1 or 2 O-alkynyl C2-C6 cycloalkyl C3-C6 E.214 (X.4) 0, 1 or 2 O-alkynyl C2-C6 cycloalkyl C3-C6 E.215 (X.5) 0, 1 or 2 O-alkynyl C2-C6 cycloalkyl C3-C6 E.216 (X.1) 0, 1 or 2 cycloalkyl C3-C6 cycloalkyl C3-C6 E.217 (X.2) 0, 1 or 2 cycloalkyl C3-C6 cycloalkyl C3-C6 E.218 (X.3) 0, 1 or 2 C3-C6 cycloalkyl C3-C6 cycloalkyl E.219 (X.4) 0, 1 or 2 C3-C6 cycloalkyl C3-C6 cycloalkyl E.220 (X.5) 0, 1 or 2 C3-C6 cycloalkyl C3-C6 cycloalkyl E.221 (X.1) 0, 1 or 2 C1-C6 alkyl C2-C6 alkenyl E.222 (X.2) 0, 1 or 2 C1-C6 alkyl C2-C6 alkenyl E.223 (X.3) 0, 1 or 2 C1-C6 alkyl C2-C6 alkenyl E.224 (X.4) 0, 1 or 2 C1-C6 alkyl C2-C6 alkenyl E.225 (X.5) 0, 1 or 2 C1-C6 alkyl C2-C6 alkenyl E.226 (X.1) 0, 1 or 2 C2-C6 alkenyl halogen E.227 (X.2) 0, 1 or 2 C2-C6 alkenyl halogen E.228 (X.3) 0, 1 or 2 C2-C6 alkenyl halogen E.229 (X.4) 0, 1 or 2 C2-C6 alkenyl halogen E.230 (X.5) 0, 1 or 2 C2-C6 alkenyl halogen E.231 (X.1) 0, 1 or 2 C1-C6 alkyl halogen C2-C6 alkenyl E.232 (X.2) 0, 1 or 2 C1-C6 alkyl halogen C2-C6 alkenyl E.233 (X.3) 0, 1 or 2 halogen alkyl C1-C6 alkenyl C2-C6 E.234 (X.4) 0, 1 or 2 halogen alkyl C1-C6 alkenyl C2-C6 E.235 (X.5) 0, 1 or 2 halogen alkyl C1-C6 alkenyl C2-C6 E.236 (X.1) 0, 1 or 2 alkenyl C2-C6 alkenyl C2-C6 E.237 (X.2) 0, 1 or 2 alkenyl C2-C6 alkenyl C2-C6 E.238 (X.3) 0, 1 or 2 alkenyl C2-C6 alkenyl C2-C6. Petition 870250083202, dated 09 / 16 / 2025, pp. 187 / 317 36 / 159 Realization X n R2 R3 E.239 (X.4) 0, 1 or 2 C2-C6 alkenyl C2-C6 alkenyl E.240 (X.5) 0, 1 or 2 C2-C6 alkenyl C2-C6 alkenyl E.241 (X.1) 0, 1 or 2 C2-C6 alkenyl halogen C2-C6 alkenyl E.242 (X.2) 0, 1 or 2 C2-C6 alkenyl halogen C2-C6 alkenyl E.243 (X.3) 0, 1 or 2 C2-C6 alkenyl halogen C2-C6 alkenyl E.244 (X.4) 0, 1 or 2 C2-C6 alkenyl halogen C2-C6 alkenyl E.245 (X.5) 0, 1 or 2 halogen alkenyl C2-C6 alkenyl C2-C6 E.246 (X.1) 0, 1 or 2 alkynyl C2-C6 alkenyl C2-C6 E.247 (X.2) 0, 1 or 2 alkynyl C2-C6 alkenyl C2-C6 E.248 (X.3) 0, 1 or 2 alkynyl C2-C6 alkenyl C2-C6 E.249 (X.4) 0, 1 or 2 alkynyl C2-C6 alkenyl C2-C6 E.250 (X.5) 0, 1 or 2 alkynyl C2-C6 alkenyl C2-C6 E.251 (X.1) 0, 1 or 2 halogen alkynyl C2-C6 alkenyl C2-C6 E.252 (X.2) 0, 1 or 2 halogen alkynyl C2-C6 alkenyl C2-C6 E.253 (X.3) 0, 1 or 2 halogen alkynyl C2-C6 alkenyl C2-C6 E.254 (X.4) 0, 1 or 2 halogen alkynyl C2-C6 alkenyl C2-C6 E.255 (X.5) 0, 1 or 2 halogen C2-C6 alkenyl C2-C6 E.256 (X.1) 0, 1 or 2 O-alkyl C1-C6 alkenyl C2-C6 E.257 (X.2) 0, 1 or 2 O-alkyl C1-C6 alkenyl C2-C6 E.258 (X.3) 0, 1 or 2 O-alkyl C1-C6 alkenyl C2-C6 E.259 (X.4) 0, 1 or 2 O-alkyl C1-C6 alkenyl C2-C6 E.260 (X.5) 0, 1 or 2 O-alkyl C1-C6 alkenyl C2-C6 E.261 (X.1) 0, 1 or 2 O-alkenyl C2-C6 alkenyl C2-C6 E.262 (X.2) 0, 1 or 2 O-alkenyl C2-C6 alkenyl C2-C6 E.263 (X.3) 0, 1 or 2 O-alkenyl C2-C6 alkenyl C2-C6 E.264 (X.4) 0, 1 or 2 O-alkenyl C2-C6 alkenyl C2-C6 E.265 (X.5) 0, 1 or 2 O-alkenyl C2-C6 alkenyl C2-C6 E.266 (X.1) 0, 1 or 2 O-alkynyl C2-C6 alkenyl C2-C6 E.267 (X.2) 0, 1 or 2 O-alkynyl C2-C6 alkenyl C2-C6 E.268 (X.3) 0, 1 or 2 O-alkynyl C2-C6 alkenyl C2-C6 E.269 (X.4) 0, 1 or 2 O-alkynyl C2-C6 alkenyl C2-C6 E.270 (X.5) 0, 1 or 2 O-alkynyl C2-C6 alkenyl C2-C6 E.271 (X.1) 0, 1 or 2 cycloalkyl C3-C6 alkenyl C2-C6 E.272 (X.2) 0, 1 or 2 cycloalkyl C3-C6 alkenyl C2-C6 E.273 (X.3) 0, 1 or 2 C3-C6 cycloalkyl C2-C6 alkenyl E.274 (X.4) 0, 1 or 2 C3-C6 cycloalkyl C2-C6 alkenyl E.275 (X.5) 0, 1 or 2 C3-C6 cycloalkyl C2-C6 alkenyl. Petition 870250083202, dated 09 / 16 / 2025, pp. 188 / 317 37 / 159

[00127] In other respects, the present invention relates to embodiments E. 1 to E. 275 listed in Table 5, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.1.

[00128] In other respects, the present invention relates to embodiments E. 1 to E. 275 listed in Table 5, wherein R5 is represented by embodiment 5.2 and R6 is represented by embodiment 6.1.

[00129] In other respects, the present invention relates to embodiments E. 1 to E. 275 listed in Table 5, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.1.

[00130] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.1.

[00131] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.2.

[00132] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.2 and R6 is represented by embodiment 6.2.

[00133] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.2.

[00134] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.2.

[00135] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.3.

[00136] In other respects, the present invention relates to Petition 870250083202, dated 09 / 16 / 2025, pp. 189 / 317 38 / 159 realizations E.1 to E.275 are listed in Table 5, where R5 is represented by realization 5.2 and R6 is represented by realization 6.3.

[00137] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.3.

[00138] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.3.

[00139] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 and R6 are represented by embodiment 6.4.

[00140] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R5 and R6 are represented by embodiment 6.5.

[00141] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.1 and R8 is represented by embodiment 8.1.

[00142] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.1.

[00143] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.1.

[00144] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.1.

[00145] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, where R7 is represented Petition 870250083202, dated 09 / 16 / 2025, pp. 190 / 317 39 / 159 is represented by realization 7.1 and R8 is represented by realization 8.2.

[00146] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.2.

[00147] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.2.

[00148] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.2.

[00149] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.1 and R8 is represented by embodiment 8.3.

[00150] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.3.

[00151] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.3.

[00152] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.3.

[00153] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 and R8 are represented by embodiment 8.4.

[00154] In other respects, the present invention relates to embodiments E.1 to E.275 listed in Table 5, wherein R7 and R8 are represented by embodiment 8.7. Petition 870250083202, dated 09 / 16 / 2025, pp. 191 / 317 40 / 159

[00155] Particularly in view of their use, according to one embodiment, preference is given to compounds IA-1, IA-2, IA-3, IA-4, IA-5, IA-6, IA-7, IA-8, IA-9; IB-1, IB-2, IB-3, IB-4, IB-5, IB-6; IC-1, IC-2, IC-3, IC-4, IC-5 and IC-6; which are compiled in Table 6. Each of the groups mentioned for a substituent in the tables is also intrinsically, independent of the combination in which it is mentioned, a particularly preferred aspect of the substituent in question: Ά / * ~TA / LO / \ IO / \ ct z^A. - oí z \\ 2 <λ z >- cm / \ ' “AP 5 “A q Ϊ <\ > K Μ δ * CM T- CM XX XX co \ / co \ / Qí / =\ QÍ / =\ T- OJ s ''dp ϊ ^\ <ην=\ o: za - oi z^a q*—y n r k wo \ m a r- cm t- xx <o 00 ü tz =\ ££ k \\Petition 870250083202, dated 09 / 16 / 2025, pp. 192 / 317 41 / 159 IC-4 IC-5 Compounds 1a

[00156] Compounds of formula IA-1, IA-2, IA-3, IA-4, IA-5, IA-6; IB-1, IB-2, IB-3, IB-4, IB-5, IB-6; IC-1, IC-2, IC-3, IC-4, IC-5 and IC-6, where the meaning for the combination of X1, X2, R5, R6, R7 and R8 for each individual compound corresponds, in each case, to a row in Table 6 (compounds IA-1.1aB-1 to IA-1.1aB-672, IA-2.1aB-1 to IA-2.1aB-672, IA-3.1aB-1 to IA-3.1aB-672, IA-4.1aB-1 to IA-4.1aB-672, IA-5.1aB-1 to IA Petition 870250083202, dated 09 / 16 / 2025, pp. 193 / 317 42 / 159 5.1a.B-672, I.A-6.1a.B-1 a I.A-6.1a.B-672, I.A-7.1a.B-1 a I.A-7.1a.B-672, I.A8.1a.B-1 a I.A-8.1a.B-672 e I.A-9.1a.B-1 a I.A-9.1a.B-672; compostos I.B-1.1a.B1 a I.B-1.1a.B-672, I.B-2.1a.B-1 a I.B-2.1a.B-672, I.B-3.1a.B-1 a I.B-3.1a.B-672, I.B-4.1a.B-1 a I.B-4.1a.B-672, I.B-5.1a.B-1 a I.B-5.1a.B-672 e I.B-6.1a.B-1 a I.B6.1a.B-672; e compostos I.C-1.1a.B-1 a I.C-1.1a.B-672, I.C-2.1a.B-1 a I.C2.1a.B-672, I.C-3.1a.B-1 a I.C-3.1a.B-672, I.C-4.1a.B-1 a I.C-4.1a.B-672, I.C5.1a.B-1 a I.C-5.1a.B-672 e I.C-6.1a.B-1 a I.C-6.1a.B-672). Tabela 6 N° X1 X2 R5 R6 R7 R8 B-1 HHHHHH B-2 HHH CH3 HH B-3 HH CH3 CH3 HH B-4 HH =OHH B-5 HH -CH2-CH2- HH B-6 HH -CH2-CH2-CH2- HH B-7 HH -CH2-CH2-CH2-CH2- HH B-8 HHHHH CH3 B-9 HHH CH3 H CH3 B-10 HH CH3 CH3 H CH3 B-11 HH =OH CH3 B-12 HH -CH2-CH2- H CH3 B-13 HH -CH2-CH2-CH2- H CH3 B-14 HH -CH2-CH2-CH2-CH2- H CH3 B-15 HHHH CH3 CH3 B-16 HHH CH3 CH3 CH3 B-17 HH CH3 CH3 CH3 CH3 B-18 HH =O CH3 CH3 B-19 HH -CH2-CH2- CH3 CH3 B-20 HH -CH2-CH2-CH2- CH3 CH3 B-21 HH -CH2-CH2-CH2-CH2- CH3 CH3 B-22 HHHH -CH2-CH2- B-23 HHH CH3 -CH2-CH2- B-24 HH CH3 CH3 -CH2-CH2- B-25 HH =O -CH2-CH2- B-26 HH -CH2-CH2- -CH2-CH2- B-27 HH -CH2-CH2-CH2- -CH2-CH2- B-28 HH -CH2-CH2-CH2-CH2- -CH2-CH2- B-29 HHHH -CH2-CH2-CH2- B-30 HHH CH3 -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 194 / 317 43 / 159 N° X1 X2 R5 R6 R7 R8 B-31 HH CH3 CH3 -CH2-CH2-CH2- B-32 HH =O -CH2-CH2-CH2- B-33 HH -CH2-CH2- -CH2-CH2-CH2- B-34 HH -CH2-CH2-CH2- -CH2-CH2-CH2- B-35 HH -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-36 HHHH -CH2-CH2-CH2-CH2- B-37 HHH CH3 -CH2-CH2-CH2-CH2- B-38 HH CH3 CH3 -CH2-CH2-CH2-CH2- B-39 HH =O -CH2-CH2-CH2-CH2- B-40 HH -CH2-CH2- -CH2-CH2-CH2-CH2- B-41 HH -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-42 HH -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-43 HFHHHH B-44 HFH CH3 HH B-45 HF CH3 CH3 HH B-46 HF =OHH B-47 HF -CH2-CH2- HH B-48 HF -CH2-CH2-CH2- HH B-49 HF -CH2-CH2-CH2-CH2- HH B-50 HFHHH CH3 B-51 HFH CH3 H CH3 B-52 HF CH3 CH3 H CH3 B-53 HF =OH CH3 B-54 HF -CH2-CH2- H CH3 B-55 HF -CH2-CH2-CH2- H CH3 B-56 ​​HF -CH2-CH2-CH2- H CH3 B-57 HFHH CH3 CH3 B-58 HFH CH3 CH3 CH3 B-59 HF CH3 CH3 CH3 CH3 B-60 HF =O CH3 CH3 B-61 HF -CH2-CH2- CH3 CH3 B-62 HF -CH2-CH2-CH2- CH3 CH3 B-63 HF -CH2-CH2-CH2-CH2- CH3 CH3 B-64 HFHH -CH2-CH2- B-65 HFH CH3 -CH2-CH2- B-66 HF CH3 CH3 -CH2-CH2- B-67 HF =O -CH2-CH2- B-68 HF -CH2-CH2- -CH2-CH2- B-69 HF -CH2-CH2-CH2- -CH2-CH2- B-70 HF -CH2-CH2-CH2-CH2- -CH2-CH2- B-71 HFHH -CH2-CH2-CH2- B-72 HFH CH3 -CH2-CH2-CH2- B-73 HF CH3 CH3 -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 195 / 317 44 / 159 N° X1 X2 R5 R6 R7 R8 B-74 HF =O -CH2-CH2-CH2- B-75 HF -CH2-CH2- -CH2-CH2-CH2- B-76 HF -CH2-CH2-CH2- -CH2-CH2-CH2- B-77 HF -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-78 HFHH -CH2-CH2-CH2-CH2- B-79 HFH CH3 -CH2-CH2-CH2-CH2- B-80 HF CH3 CH3 -CH2-CH2-CH2-CH2- B-81 HF =O -CH2-CH2-CH2-CH2- B-82 HF -CH2-CH2- -CH2-CH2-CH2-CH2- B-83 HF -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-84 HF -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-85 H SCH3 HHHH B-86 H SCH3 H CH3 HH B-87 H SCH3 CH3 CH3 HH B-88 H SCH3 =OHH B-89 H SCH3 -CH2-CH2- HH B-90 H SCH3 -CH2-CH2-CH2- HH B-91 H SCH3 -CH2-CH2-CH2-CH2- HH B-92 H SCH3 HHH CH3 B-93 H SCH3 H CH3 H CH3 B-94 H SCH3 CH3 CH3 H CH3 B-95 H SCH3 =OH CH3 B-96 H SCH3 -CH2-CH2- H CH3 B-97 H SCH3 -CH2-CH2-CH2- H CH3 B-98 H SCH3 -CH2-CH2-CH2-CH2- H CH3 B-99 H SCH3 HH CH3 CH3 B-100 H SCH3 H CH3 CH3 CH3 B-101 H SCH3 CH3 CH3 CH3 CH3 B-102 H SCH3 =O CH3 CH3 B-103 H SCH3 -CH2-CH2- CH3 CH3 B-104 H SCH3 -CH2-CH2-CH2- CH3 CH3 B-105 H SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-106 H SCH3 HH-CH2-CH2- B-107 H SCH3 H CH3 -CH2-CH2- B-108 H SCH3 CH3 CH3 -CH2-CH2- B-109 H SCH3 =O -CH2-CH2- B-110 H SCH3 -CH2-CH2- -CH2-CH2- B-111 H SCH3 -CH2-CH2-CH2- -CH2-CH2- B-112 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-113 H SCH3 HH -CH2-CH2-CH2- B-114 H SCH3 H CH3 -CH2-CH2-CH2- B-115 H SCH3 CH3 CH3 -CH2-CH2-CH2- B-116 H SCH3 =O -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 196 / 317 45 / 159 N° X1 X2 R5 R6 R7 R8 B-117 H SCH3 -CH2-CH2- -CH2-CH2-CH2- B-118 H SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-119 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-120 H SCH3 HH -CH2-CH2-CH2-CH2- B-121 H SCH3 H CH3 -CH2-CH2-CH2-CH2- B-122 H SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-123 H SCH3 =O -CH2-CH2-CH2-CH2- B-124 H SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-125 H SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-126 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-127 H OCH3 HHHH B-128 H OCH3 H CH3 HH B-129 H OCH3 CH3 CH3 HH B-130 H OCH3 =OHH B-131 H OCH3 -CH2-CH2- HH B-132 H OCH3 -CH2-CH2-CH2- HH B-133 H OCH3 -CH2-CH2-CH2-CH2- HH B-134 H OCH3 HHH CH3 B-135 H OCH3 H CH3 H CH3 B-136 H OCH3 CH3 CH3 H CH3 B-137 H OCH3 =OH CH3 B-138 H OCH3 -CH2-CH2- H CH3 B-139 H OCH3 -CH2-CH2-CH2- H CH3 B-140 H OCH3 -CH2-CH2-CH2-CH2- H CH3 B-141 H OCH3 HH CH3 CH3 B-142 H OCH3 H CH3 CH3 CH3 B-143 H OCH3 CH3 CH3 CH3 CH3 B-144 H OCH3 =O CH3 CH3 B-145 H OCH3 -CH2-CH2- CH3 CH3 B-146 H OCH3 -CH2-CH2-CH2- CH3 CH3 B-147 H OCH3-CH2-CH2-CH2-CH2- CH3 CH3 B-148 H OCH3 HH -CH2-CH2- B-149 H OCH3 H CH3 -CH2-CH2- B-150 H OCH3 CH3 CH3 -CH2-CH2- B-151 H OCH3 =O -CH2-CH2- B-152 H OCH3 -CH2-CH2- -CH2-CH2- B-153 H OCH3 -CH2-CH2-CH2- -CH2-CH2- B-154 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-155 H OCH3 HH -CH2-CH2-CH2- B-156 H OCH3 H CH3 -CH2-CH2-CH2- B-157 H OCH3 CH3 CH3 -CH2-CH2-CH2- B-158 H OCH3 =O -CH2-CH2-CH2- B-159 H OCH3 -CH2-CH2- -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 197 / 317 46 / 159 N° X1 X2 R5 R6 R7 R8 B-160 H OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-161 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-162 H OCH3 HH -CH2-CH2-CH2-CH2- B-163 H OCH3 H CH3 -CH2-CH2-CH2-CH2- B-164 H OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-165 H OCH3 =O -CH2-CH2-CH2-CH2- B-166 H OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-167 H OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-168 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-169 FHHHHH B-170 FHH CH3 HH B-171 FH CH3 CH3 HH B-172 FH =OHH B-173 FH -CH2-CH2- HH B-174 FH -CH2-CH2-CH2- HH B-175 FH -CH2-CH2-CH2-CH2- HH B-176 FHHHH CH3 B-177 FHH CH3 H CH3 B-178 FH CH3 CH3 H CH3 B-179 FH =OH CH3 B-180 FH -CH2-CH2- H CH3 B-181 FH -CH2-CH2-CH2- H CH3 B-182 FH -CH2-CH2-CH2-CH2- H CH3 B-183 FHHH CH3 CH3 B-184 FHH CH3 CH3 CH3 B-185 FH CH3 CH3 CH3 CH3 B-186 FH =O CH3 CH3 B-187 FH -CH2-CH2- CH3 CH3 B-188 FH -CH2-CH2-CH2- CH3 CH3 B-189 FH -CH2-CH2-CH2-CH2-CH3 CH3 B-190 FHHH -CH2-CH2- B-191 FHH CH3 -CH2-CH2- B-192 FH CH3 CH3 -CH2-CH2- B-193 FH=O -CH2-CH2- B-194 FH -CH2-CH2- -CH2-CH2- B-195 FH -CH2-CH2-CH2- -CH2-CH2- B-196 FH -CH2-CH2-CH2-CH2- -CH2-CH2- B-197 FHHH -CH2-CH2-CH2- B-198 FHH CH3 -CH2-CH2-CH2- B-199 FH CH3 CH3 -CH2-CH2-CH2- B-200 FH =O -CH2-CH2-CH2- B-201 FH -CH2-CH2- -CH2-CH2-CH2- B-202 FH -CH2-CH2-CH2- -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 198 / 317 47 / 159 N° X1 X2 R5 R6 R7 R8 B-203 FH -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-204 FHHH -CH2-CH2-CH2-CH2- B-205 FHH CH3 -CH2-CH2-CH2-CH2- B-206 FH CH3 CH3 -CH2-CH2-CH2-CH2- B-207 FH =O -CH2-CH2-CH2-CH2- B-208 FH -CH2-CH2- -CH2-CH2-CH2-CH2- B-209 FH -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-210 FH -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-211 FFHHHH B-212 FFH CH3 HH B-213 FF CH3 CH3 HH B-214 FF =OHH B-215 FF -CH2-CH2- HH B-216 FF -CH2-CH2-CH2- HH B-217 FF -CH2-CH2-CH2-CH2- HH B-218 FFHHH CH3 B-219 FFH CH3 H CH3 B-220 FF CH3 CH3 H CH3 B-221 FF =OH CH3 B-222 FF -CH2-CH2- H CH3 B-223 FF -CH2-CH2-CH2- H CH3 B-224 FF -CH2-CH2-CH2-CH2- H CH3 B-225 FFHH CH3 CH3 B-226 FFH CH3 CH3 B-227 FF CH3 CH3 CH3 B-228 FF =O CH3 CH3 B-229 FF -CH2-CH2- CH3 B-230 FF -CH2-CH2-CH2- CH3 CH3 B-231 FF -CH2-CH2-CH2-CH2- CH3 CH3 B-232 FFHH -CH2-CH2- B-233 FFH CH3 -CH2-CH2- B-234 FF CH3 CH3 -CH2-CH2- B-235 FF =O -CH2-CH2- B-236 FF -CH2-CH2- -CH2-CH2- B-237 FF-CH2-CH2-CH2- -CH2-CH2- B-238 FF -CH2-CH2-CH2-CH2- -CH2-CH2- B-239 FFHH -CH2-CH2-CH2- B-240 FFH CH3 -CH2-CH2-CH2- B-241 FF CH3 CH3 -CH2-CH2-CH2- B-242 FF =O -CH2-CH2-CH2- B-243 FF -CH2-CH2- -CH2-CH2-CH2- B-244 FF -CH2-CH2-CH2- -CH2-CH2-CH2- B-245 FF -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 199 / 317 48 / 159 N° X1 X2 R5 R6 R7 R8 B-246 FFHH -CH2-CH2-CH2-CH2- B-247 FFH CH3 -CH2-CH2-CH2-CH2- B-248 FF CH3 CH3 -CH2-CH2-CH2-CH2- B-249 FF =O -CH2-CH2-CH2-CH2- B-250 FF -CH2-CH2- -CH2-CH2-CH2-CH2- B-251 FF -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-252 FF -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-253 F SCH3 HHHH B-254 F SCH3 H CH3 HH B-255 F SCH3 CH3 CH3 HH B-256 F SCH3 =OHH B-257 F SCH3 -CH2-CH2- HH B-258 F SCH3 -CH2-CH2-CH2- HH B-259 F SCH3 -CH2-CH2-CH2-CH2- HH B-260 F SCH3 HHH CH3 B-261 F SCH3 H CH3 H CH3 B-262 F SCH3 CH3 CH3 H CH3 B-263 F SCH3 =OH CH3 B-264 F SCH3 -CH2-CH2- H CH3 B-265 F SCH3 -CH2-CH2-CH2- H CH3 B-266 F SCH3 -CH2-CH2-CH2-CH2- H CH3 B-267 F SCH3 HH CH3 CH3 B-268 F SCH3 H CH3 CH3 CH3 B-269 F SCH3 CH3 CH3 CH3 CH3 B-270 F SCH3 =O CH3 CH3 B-271 F SCH3 -CH2-CH2- CH3 CH3 B-272 F SCH3 -CH2-CH2-CH2- CH3 CH3 B-273 F SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-274 F SCH3 HH -CH2-CH2- B-275 F SCH3 H CH3 -CH2-CH2- B-276 F SCH3 CH3 CH3 -CH2-CH2- B-277 F SCH3 =O -CH2-CH2- B-278 F SCH3-CH2-CH2- -CH2-CH2- B-279 F SCH3 -CH2-CH2-CH2- -CH2-CH2- B-280 F SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-281 F SCH3 HH -CH2-CH2-CH2- B-282 F SCH3 H CH3 -CH2-CH2-CH2- B-283 F SCH3 CH3 CH3 -CH2-CH2-CH2- B-284 F SCH3 =O -CH2-CH2-CH2- B-285 F SCH3 -CH2-CH2- -CH2-CH2-CH2- B-286 F SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-287 F SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-288 F SCH3 HH -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 200 / 317 49 / 159 N° X1 X2 R5 R6 R7 R8 B-289 F SCH3 H CH3 -CH2-CH2-CH2-CH2- B-290 F SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-291 F SCH3 =O -CH2-CH2-CH2-CH2- B-292 F SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-293 F SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-294 F SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-295 F OCH3 HHHH B-296 F OCH3 H CH3 HH B-297 F OCH3 CH3 CH3 HH B-298 F OCH3 =OHH B-299 F OCH3 -CH2-CH2- HH B-300 F OCH3 -CH2-CH2-CH2- HH B-301 F OCH3 -CH2-CH2-CH2-CH2- HH B-302 F OCH3 HHH CH3 B-303 F OCH3 H CH3 H CH3 B-304 F OCH3 CH3 CH3 H CH3 B-305 F OCH3 =OH CH3 B-306 F OCH3 -CH2-CH2- H CH3 B-307 F OCH3 -CH2-CH2-CH2- H CH3 B-308 F OCH3 -CH2-CH2-CH2-CH2- H CH3 B-309 F OCH3 HH CH3 CH3 B-310 F OCH3 H CH3 CH3 CH3 B-311 F OCH3 CH3 CH3 CH3 CH3 B-312 F OCH3 =O CH3 CH3 B-313 F OCH3 -CH2-CH2- CH3 CH3 B-314 F OCH3 -CH2-CH2-CH2- CH3 CH3 B-315 F OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-316 F OCH3 HH -CH2-CH2- B-317 F OCH3 H CH3 -CH2-CH2- B-318 F OCH3 CH3 CH3 -CH2-CH2- B-319 F OCH3 =O -CH2-CH2- B-320 F OCH3 -CH2-CH2- -CH2-CH2-B-321 F OCH3 -CH2-CH2-CH2- -CH2-CH2- B-322 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-323 F OCH3 HH -CH2-CH2-CH2- B-324 F OCH3 H CH3 -CH2-CH2-CH2- B-325 F OCH3 CH3 CH3 -CH2-CH2-CH2- B-326 F OCH3 =O -CH2-CH2-CH2- B-327 F OCH3 -CH2-CH2- -CH2-CH2-CH2- B-328 F OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-329 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-330 F OCH3 HH -CH2-CH2-CH2-CH2- B-331 F OCH3 H CH3 -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 201 / 317 50 / 159 N° X1 X2 R5 R6 R7 R8 B-332 F OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-333 F OCH3 =O -CH2-CH2-CH2-CH2- B-334 F OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-335 F OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-336 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-337 CCH HHHHH B-338 CCH HH CH3 HH B-339 CCH H CH3 CH3 HH B-340 CCH H =OHH B-341 CCH H -CH2-CH2- HH B-342 CCH H -CH2-CH2-CH2- HH B-343 CCH H -CH2-CH2-CH2-CH2- HH B-344 CCH HHHH CH3 B-345 CCH HH CH3 H CH3 B-346 CCH H CH3 CH3 H CH3 B-347 CCH H =OH CH3 B-348 CCH H -CH2-CH2- H CH3 B-349 CCH H -CH2-CH2-CH2- H CH3 B-350 CCH H -CH2-CH2-CH2-CH2- H CH3 B-351 CCH HHH CH3 CH3 B-352 CCH HH CH3 CH3 B-353 CCH H CH3 CH3 CH3 B-354 CCH H =O CH3 CH3 B-355 CCH H -CH2-CH2- CH3 CH3 B-356 CCH H -CH2-CH2-CH2- CH3 B-357 CCH H -CH2-CH2-CH2-CH2- CH3 CH3 B-358 CCH HHH -CH2-CH2- B-359 CCH HH CH3 -CH2-CH2- B-360 CCH H CH3 CH3 -CH2-CH2- B-361 CCH H =O -CH2-CH2- B-362 CCH H -CH2-CH2- -CH2-CH2- B-363 CCH H -CH2-CH2-CH2- -CH2-CH2- B-364 CCH H-CH2-CH2-CH2-CH2- -CH2-CH2- B-365 CCH HHH -CH2-CH2-CH2- B-366 CCH HH CH3 -CH2-CH2-CH2- B-367 CCH H CH3 CH3 -CH2-CH2-CH2- B-368 CCH H =O -CH2-CH2-CH2- B-369 CCH H -CH2-CH2- -CH2-CH2-CH2- B-370 CCH H -CH2-CH2-CH2- -CH2-CH2-CH2- B-371 CCH H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-372 CCH HHH -CH2-CH2-CH2-CH2- B-373 CCH HH CH3 -CH2-CH2-CH2-CH2- B-374 CCH H CH3 CH3 -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 202 / 317 51 / 159 N° X1 X2 R5 R6 R7 R8 B-375 CCH H =O -CH2-CH2-CH2-CH2- B-376 CCH H -CH2-CH2- -CH2-CH2-CH2-CH2- B-377 CCH H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-378 CCH H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-379 CCH FHHHH B-380 CCH FH CH3 HH B-381 CCH F CH3 CH3 HH B-382 CCH F =OHH B-383 CCH F -CH2-CH2- HH B-384 CCH F -CH2-CH2-CH2- HH B-385 CCH F -CH2-CH2-CH2-CH2- HH B-386 CCH FHHH CH3 B-387 CCH FH CH3 H CH3 B-388 CCH F CH3 CH3 H CH3 B-389 CCH F =OH CH3 B-390 CCH F -CH2-CH2- H CH3 B-391 CCH F -CH2-CH2-CH2- H CH3 B-392 CCH F -CH2-CH2-CH2-CH2- H CH3 B-393 CCH FHH CH3 CH3 B-394 CCH FH CH3 CH3 CH3 B-395 CCH F CH3 CH3 CH3 B-396 CCH F =O CH3 CH3 B-397 CCH F -CH2-CH2- CH3 CH3 B-398 CCH F -CH2-CH2-CH2- CH3 CH3 B-399 CCH F -CH2-CH2-CH2-CH2-CH3 CH3 B-400 CCH FHH -CH2-CH2- B-401 CCH FH CH3 -CH2-CH2- B-402 CCH F CH3 CH3 -CH2-CH2- B-403 CCH F =O -CH2-CH2- B-404 CCH F -CH2-CH2- -CH2-CH2- B-405 CCH F -CH2-CH2-CH2- -CH2-CH2- B-406 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2- B-407 CCH FHH -CH2-CH2-CH2-CH2-B-408 CCH FH CH3 -CH2-CH2-CH2- B-409 CCH F CH3 CH3 -CH2-CH2-CH2- B-410 CCH F =O -CH2-CH2-CH2- B-411 CCH F -CH2-CH2- -CH2-CH2-CH2- B-412 CCH F -CH2-CH2-CH2- -CH2-CH2-CH2- B-413 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-414 CCH FHH -CH2-CH2-CH2-CH2- B-415 CCH FH CH3 -CH2-CH2-CH2-CH2- B-416 CCH F CH3 CH3 -CH2-CH2-CH2-CH2- B-417 CCH F =O -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 203 / 317 52 / 159 N° X1 X2 R5 R6 R7 R8 B-418 CCH F -CH2-CH2- -CH2-CH2-CH2-CH2- B-419 CCH F -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-420 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-421 CCH SCH3 HHHH B-422 CCH SCH3 H CH3 HH B-423 CCH SCH3 CH3 CH3 HH B-424 CCH SCH3 =OHH B-425 CCH SCH3 -CH2-CH2- HH B-426 CCH SCH3 -CH2-CH2-CH2- HH B-427 CCH SCH3 -CH2-CH2-CH2-CH2- HH B-428 CCH SCH3 HHH CH3 B-429 CCH SCH3 H CH3 H CH3 B-430 CCH SCH3 CH3 CH3 H CH3 B-431 CCH SCH3 =OH CH3 B-432 CCH SCH3 -CH2-CH2- H CH3 B-433 CCH SCH3 -CH2-CH2-CH2- H CH3 B-434 CCH SCH3 -CH2-CH2-CH2-CH2- H CH3 B-435 CCH SCH3 HH CH3 CH3 B-436 CCH SCH3 H CH3 CH3 CH3 B-437 CCH SCH3 CH3 CH3 CH3 CH3 B-438 CCH SCH3 =O CH3 CH3 B-439 CCH SCH3 -CH2-CH2- CH3 CH3 B-440 CCH SCH3 -CH2-CH2-CH2- CH3 CH3 B-441 CCH SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-442 CCH SCH3 HH -CH2-CH2- B-443 CCH SCH3 H CH3 -CH2-CH2- B-444 CCH SCH3 CH3 CH3 -CH2-CH2- B-445 CCH SCH3 =O -CH2-CH2- B-446 CCH SCH3 -CH2-CH2- -CH2-CH2- B-447 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2- B-448 CCH SCH3-CH2-CH2-CH2-CH2- -CH2-CH2- B-449 CCH SCH3 HH -CH2-CH2-CH2- B-450 CCH SCH3 H CH3 -CH2-CH2-CH2- B-451 CCH SCH3 CH3 CH3 -CH2-CH2-CH2- B-452 CCH SCH3 =O -CH2-CH2-CH2- B-453 CCH SCH3 -CH2-CH2- -CH2-CH2-CH2- B-454 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-455 CCH SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-456 CCH SCH3 HH -CH2-CH2-CH2-CH2- B-457 CCH SCH3 H CH3 -CH2-CH2-CH2-CH2- B-458 CCH SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-459 CCH SCH3 =O -CH2-CH2-CH2-CH2- B-460 CCH SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 204 / 317 53 / 159 N° X1 X2 R5 R6 R7 R8 B-461 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-462 CCH SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-463 CCH OCH3 HHHH B-464 CCH OCH3 H CH3 HH B-465 CCH OCH3 CH3 CH3 HH B-466 CCH OCH3 =OHH B-467 CCH OCH3 -CH2-CH2- HH B-468 CCH OCH3 -CH2-CH2-CH2- HH B-469 CCH OCH3 -CH2-CH2-CH2-CH2- HH B-470 CCH OCH3 HHH CH3 B-471 CCH OCH3 H CH3 H CH3 B-472 CCH OCH3 CH3 CH3 H CH3 B-473 CCH OCH3 =OH CH3 B-474 CCH OCH3 -CH2-CH2- H CH3 B-475 CCH OCH3 -CH2-CH2-CH2- H CH3 B-476 CCH OCH3 -CH2-CH2-CH2-CH2- H CH3 B-477 CCH OCH3 HH CH3 CH3 B-478 CCH OCH3 H CH3 CH3 CH3 B-479 CCH OCH3 CH3 CH3 CH3 CH3 B-480 CCH OCH3 =O CH3 CH3 B-481 CCH OCH3 -CH2-CH2- CH3 CH3 B-482 CCH OCH3 -CH2-CH2-CH2- CH3 CH3 B-483 CCH OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-484 CCH OCH3 HH -CH2-CH2- B-485 CCH OCH3 H CH3 -CH2-CH2- B-486 CCH OCH3 CH3 CH3 -CH2-CH2- B-487 CCH OCH3 =O -CH2-CH2- B-488 CCH OCH3 -CH2-CH2- -CH2-CH2- B-489 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2- B-490 CCH OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-491 CCHOCH3 HH -CH2-CH2-CH2- B-492 CCH OCH3 H CH3 -CH2-CH2-CH2- B-493 CCH OCH3 CH3 CH3 -CH2-CH2-CH2- B-494 CCH OCH3 =O -CH2-CH2-CH2- B-495 CCH OCH3 -CH2-CH2- -CH2-CH2-CH2- B-496 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-497 CCH OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-498 CCH OCH3 HH -CH2-CH2-CH2-CH2- B-499 CCH OCH3 H CH3 -CH2-CH2-CH2-CH2- B-500 CCH OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-501 CCH OCH3 =O -CH2-CH2-CH2-CH2- B-502 CCH OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-503 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 205 / 317 54 / 159 N° X1 B-510 CH3 H -CH2-CH2-CH2- HH B-511 CH3 H -CH2-CH2-CH2-CH2- HH B-512 CH3 HHHH CH3 B-513 CH3 HH CH3 H CH3 B-514 CH3 H CH3 CH3 H CH3 B-515 CH3 H =OH CH3 B-516 CH3 H -CH2-CH2- H CH3 B-517 CH3 H -CH2-CH2-CH2- H CH3 B-518 CH3 H -CH2-CH2-CH2-CH2- H CH3 B-519 CH3 HHH CH3 CH3 B-520 CH3 HH CH3 CH3 CH3 B-521 CH3 H CH3 CH3 CH3 CH3 B-522 CH3 H =O CH3 CH3 B-523 CH3 H -CH2-CH2- CH3 CH3 B-524 CH3 H -CH2-CH2-CH2- CH3 CH3 B-525 CH3 H -CH2-CH2-CH2-CH2- CH3 CH3 B-526 CH3 HHH -CH2-CH2- B-527 CH3 HH CH3 -CH2-CH2- B-528 CH3 H CH3 CH3 -CH2-CH2- B-529 CH3 H =O -CH2-CH2- B-530 CH3 H -CH2-CH2- -CH2-CH2- B-531 CH3 H -CH2-CH2-CH2- -CH2-CH2- B-532 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2- B-533 CH3 HHH -CH2-CH2-CH2- B-534 CH3 HH CH3 -CH2-CH2-CH2- B-535 CH3 H CH3 CH3 -CH2-CH2-CH2- B-536 CH3 H =O -CH2-CH2-CH2- B-537 CH3 H-CH2-CH2- -CH2-CH2-CH2- B-538 CH3 H -CH2-CH2-CH2- -CH2-CH2-CH2- B-539 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-540 CH3 HHH -CH2-CH2-CH2-CH2- B-541 CH3 HH CH3 -CH2-CH2-CH2-CH2- B-542 CH3 H CH3 CH3 -CH2-CH2-CH2-CH2- B-543 CH3 H =O -CH2-CH2-CH2-CH2- B-544 CH3 H -CH2-CH2- -CH2-CH2-CH2-CH2- B-545 CH3 H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-546 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- Petition 870250083202, of 16 / 09 / 2025, page. 206 / 317 55 / 159 N° X1 X2 R5 R6 R7 R8 B-547 CH3 FHHHH B-548 CH3 FH CH3 HH B-549 CH3 F CH3 CH3 HH B-550 CH3 F =OHH B-551 CH3 F -CH2-CH2- HH B-552 CH3 F -CH2-CH2-CH2- HH B-553 CH3 F -CH2-CH2-CH2- HH B-554 CH3 FHHH CH3 B-555 CH3 FH CH3 H CH3 B-556 CH3 F CH3 CH3 H CH3 B-557 CH3 F =OH CH3 B-558 CH3 F -CH2-CH2- H CH3 B-559 CH3 F -CH2-CH2-CH2- H CH3 B-560 CH3 F -CH2-CH2-CH2- H CH3 B-561 CH3 FHH CH3 CH3 B-562 CH3 FH CH3 CH3 CH3 B-563 CH3 F CH3 CH3 CH3 CH3 B-564 CH3 F =O CH3 CH3 B-565 CH3 F -CH2-CH2- CH3 CH3 B-566 CH3 F -CH2-CH2-CH2- CH3 CH3 B-567 CH3 F -CH2-CH2-CH2-CH2- CH3 CH3 B-568 CH3 FHH -CH2-CH2- B-569 CH3 FH CH3 -CH2-CH2- B-570 CH3 F CH3 CH3 -CH2-CH2- B-571 CH3 F =O -CH2-CH2- B-572 CH3 F -CH2-CH2- -CH2-CH2- B-573 CH3 F -CH2-CH2-CH2- -CH2-CH2- B-574 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2- B-575 CH3 FHH -CH2-CH2-CH2- B-576 CH3 FH CH3 -CH2-CH2-CH2- B-577 CH3 F CH3 CH3 -CH2-CH2-CH2- B-578 CH3 F =O -CH2-CH2-CH2- B-579 CH3 F -CH2-CH2- -CH2-CH2-CH2- B-580 CH3 F -CH2-CH2-CH2--CH2-CH2-CH2- B-581 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-582 CH3 FHH -CH2-CH2-CH2-CH2- B-583 CH3 FH CH3 -CH2-CH2-CH2-CH2- B-584 CH3 F CH3 CH3 -CH2-CH2-CH2-CH2- B-585 CH3 F =O -CH2-CH2-CH2-CH2- B-586 CH3 F -CH2-CH2- -CH2-CH2-CH2-CH2- B-587 CH3 F -CH2-CH2-CH2- -CH2-CH2-CH2- B-588 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-589 CH3 CH3 HHHH Petition 870250083202, of 16 / 09 / 2025, page. 207 / 317 56 / 159 No. X1 X2 R5 R6 R7 R8 B-590 CH3 CH3 H CH3 HH B-591 CH3 CH3 CH3 CH3 HH B-592 CH3 CH3 =OHH B-593 CH3 CH3 -CH2-CH2- HH B-594 CH3 CH3 -CH2-CH2-CH2- HH B-595 CH3 CH3 -CH2-CH2-CH2-CH2- HH B-596 CH3 CH3 HHH CH3 B-597 CH3 CH3 H CH3 H CH3 B-598 CH3 CH3 CH3 CH3 H CH3 B-599 CH3 CH3 =OH CH3 B-600 CH3 CH3 -CH2-CH2- H CH3 B-601 CH3 CH3 -CH2-CH2-CH2- H CH3 B-602 CH3 CH3 -CH2-CH2-CH2-CH2- H CH3 B-603 CH3 CH3 HH CH3 CH3 B-604 CH3 CH3 H CH3 CH3 CH3 B-605 CH3 CH3 CH3 CH3 CH3 CH3 B-606 CH3 CH3 =O CH3 CH3 B-607 CH3 CH3 -CH2-CH2- CH3 CH3 B-608 CH3 CH3 -CH2-CH2-CH2- CH3 CH3 B-609 CH3 CH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-610 CH3 CH3 HH -CH2-CH2- B-611 CH3 CH3 H CH3 -CH2-CH2- B-612 CH3 CH3 CH3 CH3 -CH2-CH2- B-613 CH3 CH3 =O -CH2-CH2- B-614 CH3 CH3 -CH2-CH2- -CH2-CH2- B-615 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2- B-616 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-617 CH3 CH3 HH -CH2-CH2-CH2- B-618 CH3 CH3 H CH3 -CH2-CH2-CH2- B-619 CH3 CH3 CH3 CH3 -CH2-CH2-CH2- B-620 CH3 CH3 =O -CH2-CH2-CH2- B-621 CH3 CH3 -CH2-CH2--CH2-CH2-CH2- B-622 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-623 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-624 CH3 CH3 HH -CH2-CH2-CH2-CH2- B-625 CH3 CH3 H CH3 -CH2-CH2-CH2-CH2- B-626 CH3 CH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-627 CH3 CH3 =O -CH2-CH2-CH2-CH2- B-628 CH3 CH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-629 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-630 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-631 CH3 OCH3 HHHH B-632 CH3 OCH3 H CH3 HH Petition 870250083202, of 16 / 09 / 2025, page. 208 / 317 57 / 159 N° X1 OCH3 HHH CH3 B-639 CH3 OCH3 H CH3 H CH3 B-640 CH3 OCH3 CH3 CH3 H CH3 B-641 CH3 OCH3 =OH CH3 B-642 CH3 OCH3 -CH2-CH2- H CH3 B-643 CH3 OCH3 -CH2-CH2-CH2- H CH3 B-644 CH3 OCH3 -CH2-CH2-CH2-CH2- H CH3 B-645 CH3 OCH3 HH CH3 CH3 B-646 CH3 OCH3 H CH3 CH3 CH3 B-647 CH3 OCH3 CH3 CH3 CH3 CH3 B-648 CH3 OCH3 =O CH3 CH3 B-649 CH3 OCH3 -CH2-CH2- CH3 CH3 B-650 CH3 OCH3 -CH2-CH2-CH2- CH3 CH3 B-651 CH3 OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-652 CH3 OCH3 HH -CH2-CH2- B-653 CH3 OCH3 H CH3 -CH2-CH2- B-654 CH3 OCH3 CH3 CH3 -CH2-CH2- B-655 CH3 OCH3 =O -CH2-CH2- B-656 CH3 OCH3 -CH2-CH2- -CH2-CH2- B-657 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2- B-658 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-659 CH3 OCH3 HH -CH2-CH2-CH2- B-660 CH3 OCH3 H CH3 -CH2-CH2-CH2- B-661 CH3 OCH3 CH3 CH3 -CH2-CH2-CH2- B-662 CH3 OCH3 =O -CH2-CH2-CH2- B-663 CH3 OCH3-CH2-CH2- -CH2-CH2-CH2- B-664 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-665 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-666 CH3 OCH3 HH -CH2-CH2-CH2-CH2- B-667 CH3 OCH3 H CH3 -CH2-CH2-CH2-CH2- B-668 CH3 OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-669 CH3 OCH3 =O -CH2-CH2-CH2-CH2- B-670 CH3 OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-671 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-672 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2-

[00157] The compounds according to the present invention can be produced as shown in the following schemes, wherein, except Petition 870250083202, dated 09 / 16 / 2025, pp. 209 / 317 58 / 159 unless otherwise indicated, the definition of each variable is as defined above for a compound of formula I. Compounds of formula I can be prepared according to methods or analogously to methods that are described in the state of the art. The synthesis utilizes commercially available starting materials or can be prepared according to conventional procedures from readily available compounds.

[00158] Compounds I can be prepared, for example, in various oxidation states (Z=S, SO or SO2) and are differentiated herein by the representation Ia (sulfide), Ib (sulfoxide) and Ic (sulfone). Compounds Ia can be prepared by means of nucleophilic aromatic substitution and subsequent ring-closing reactions of aryl ketones (3) and aminothiols, or their corresponding salts, represented by the general formula (4). These aminothiols are commercially available or can be prepared by means of many methods which should be known to those skilled in the art. The reaction would be carried out in the presence of an appropriate base (1-4 equivalents), such as Cs2CO3 or K2CO3, at ambient or elevated temperatures (40-60 °C), in a manner analogous to the procedures described in WO 2013 / 184734, 2013, A1, US 5,371,064, 1994, A or Chem. Eur. J. 2015, 21 (38), 13344-13356.

[00159] Compounds of formula I, represented herein as Ic, can be prepared by oxidation of dihydrobenzothiazepines represented by general formula Ia, using at least 2.0 eq. of a suitable oxidant, such as hydrogen peroxide in combination with a metal catalyst, such as ammonium heptamolybdate, as described in Catal. Commun. 2009, 10 (14), 1948-1951. Other methods include, but are not limited to, other oxidants, such as peracids, hypervalent iodine reagents, halogenators, perhalogenates, nitric oxides or metal oxides, as described in Phosphorus Sulfur Silicon Relat. Elem. 2020, 195, 181-193. Petition 870250083202, dated 09 / 16 / 2025, pp. 210 / 317 59 / 159

[00160] Compounds of formula Ib can be prepared by oxidation of dihydrobenzothiazepines represented by general formula Ia, using equimolar equivalents of a suitable oxidant, such as hydrogen peroxide in combination with a metallic catalyst, such as ammonium heptamolybdate, as described in Dalton Trans. 2018, 47, 1188211887. Compounds Ic can alternatively be obtained from compounds Ib by oxidation under these described conditions: Ib

[00161] Aryl ketones (3) are commercially available or can be prepared by means of an oxidation scheme of aryl alcohol 5, using, for example, manganese dioxide, as described in Inorganica Chimica Acta (2012), 382, ​​72-78, WO 2000 / 038618, CN 107879989 A or Chinese Science Bulletin 2010, 55 (25), 2817-2819:

[00162] Aryl alcohols (5) can be prepared by means of the magnesium-bromine mediated / iodine-magnesium isopropyl chloride exchange of 7 and subsequent addition of commercially available aldehydes, represented by the general formula (6). The reaction is preferably carried out at 0 °C, with a ratio Petition 870250083202, dated 09 / 16 / 2025, pp. 211 / 317 60 / 159 equimolar of iPrMgCl and aryl halides (7), whose intermediate is employed in a ratio of 1.2-1.3:1 with respect to aldehydes (6), as described in WO 2021 / 71821 A1, J. Med. Chem. (2013), 56, 10158-10170, WO 2014 / 102233 A1 or US2016 / 83401 A1:

[00163] Compounds I and their compositions, respectively, are suitable as effective fungicides against a broad spectrum of phytopathogenic fungi, including soil fungi, particularly those of the classes Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). They can be used in agricultural protection as foliar fungicides, seed coating fungicides and soil fungicides.

[00164] Compound I and its compositions are preferentially useful in controlling phytopathogenic fungi on various cultivated plants, such as cereals, for example wheat, rye, barley, triticale, oats or rice; beetroot, such as sugar beet or fodder beet; fruits, such as pomes (apples, pears, etc.), drupes (for example, plums, peaches, almonds and cherries) or soft fruits, also called berries (strawberries, raspberries, blackberries, currants, etc.); leguminous plants, such as lentils, peas, alfalfa or soybeans; oilseeds, such as canola, mustard, olive, sunflower, coconut, cocoa beans, castor bean, oil palm, peanut or soybean; cucurbits, such as pumpkin, cucumber or melon; fiber plants, such as cotton, flax, hemp or jute; citrus fruits, such as oranges, lemons, grapefruits or tangerines; fruits and vegetables, such as Petition 870250083202, dated 09 / 16 / 2025, pp. 212 / 317 61 / 159 spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, pumpkins or paprika; laurel plants, such as avocados, cinnamon or camphor; energy-producing and raw material plants, such as corn, soybeans, canola, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; grapes (table grapes and grapes for grape juice); hops; grass; Stevia; natural rubber plants, ornamental and forest plants, such as flowers, shrubs, broad-leaved trees or pines (conifers, eucalyptus, etc.); and on plant propagation material, such as seeds, and the products of these plants.

[00165] Most preferably, compounds I and their compositions, respectively, are used for the control of fungi on field crops such as potatoes, beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, canola, vegetables, sunflowers, coffee or sugar cane; fruits; grapes; ornamental plants; or vegetables such as cucumbers, tomatoes, beans or pumpkins.

[00166] The term "plant propagation material" should be understood to mean all reproductive parts of the plant, such as seeds, and plant material such as cuttings and tubers (e.g., potatoes), which can be used for plant propagation. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, buds, shoots and other plant parts, including seedlings and young plants, to be transplanted after germination or after emergence from the soil.

[00167] Preferably, treatment of plant propagation materials with compounds I and their compositions, respectively, is used to control fungi on cereals such as wheat, rye, barley and oats; rice, corn, cotton and soybeans.

[00168] According to the present invention, all cultivated plants mentioned above are understood to include all species, subspecies, variants, varieties and / or hybrids belonging to the plants. Petition 870250083202, dated 09 / 16 / 2025, pp. 213 / 317 62 / 159 corresponding cultivated varieties, including, but not limited to, winter and spring varieties, particularly in cereals such as wheat and barley, as well as canola, for example, winter wheat, spring wheat, winter barley, etc.

[00169] Corn is also known as Indian corn or Zea mays, which includes all types of corn, such as field corn and sweet corn. According to the present invention, all subspecies and / or varieties of corn are included, particularly flour corn (Zea mays var. amylacea), popcorn (Zea mays var. everta), dent corn (Zea mays var. indentata), flint corn (Zea mays var. indurata), sweet corn (Zea mays var. saccharata and var. rugosa), wax corn (Zea mays var. ceratina), amylose corn (high-amylose varieties of Zea mays), wild corn (Zea mays var. tunicata), and striped corn (Zea mays var. japonica).

[00170] Most soybean cultivars can be classified into determinate and indeterminate growth habits, while Glycine soja, the wild progenitor of soybean, is indeterminate (PNAS 2010, 107 (19) 8563-856). The indeterminate growth habit (Maturity Group, MG 00 to MG 4.9) is characterized by the continuation of vegetative growth after the onset of flowering, while determinate soybean varieties (MG 5 to MG 8) characteristically have ceased most of their vegetative growth at the beginning of flowering. According to the present invention, all soybean cultivars or varieties are included, particularly determinate and indeterminate cultivars or varieties.

[00171] The term "cultivated plants" should be understood as including plants that have been modified through mutagenesis or genetic engineering to provide a new characteristic to a plant or to modify an existing characteristic. Mutagenesis includes random mutagenesis using X-rays or mutagenic chemicals. Petition 870250083202, dated 09 / 16 / 2025, pp. 214 / 317 63 / 159 but also directed mutagenesis to create mutations at specific locations in the plant genome. Directed mutagenesis often uses oligonucleotides or proteins such as CRISPR / Cas, zinc finger nucleases, TALENs, or meganucleases. Genetic engineering typically uses recombinant DNA techniques to create modifications to a plant's genome that, under natural circumstances, cannot be easily obtained through backcrossing, mutagenesis, or natural recombination. Typically, one or more genes are integrated into a plant's genome to add, improve, or modify a characteristic. These integrated genes are also called transgenes, while the plant comprising these transgenes is called a transgenic plant. The plant transformation process typically produces several transformation events, which differ depending on the genomic location where the transgene was integrated.Plants that comprise a specific transgene at a specific genomic locus are typically described as comprising a specific "event," which is indicated by a specific event name. Traits that have been introduced into plants or modified include herbicide tolerance, insect resistance, increased yield, and tolerance to abiotic conditions such as drought.

[00172] Tolerance to herbicides has been created using mutagenesis and genetic engineering. Plants that have become tolerant to acetolactate synthase (ALS) inhibitor herbicides through mutagenesis and cultivation are available, for example, under the name Clearfield®. Tolerance to glyphosate, glufosinate, 2,4-D, dicamba, oxinyl herbicides such as bromoxynil and ioxynil, sulfonylurea herbicides, ALS inhibitors, and 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors such as isoxaflutol and mesotrione has been created using transgenes.

[00173] Transgenes to provide herbicide tolerance traits include: for glyphosate tolerance: cp4 epsps, Petition 870250083202, dated 09 / 16 / 2025, pages 215 / 317 64 / 159 epsps grg23ace5, mepsps, 2mepsps, gat4601, gat4621 and goxv247; for glufosinate tolerance: pat and bar; for 2,4-D tolerance: aad-1 and aad-12; for dicamba tolerance: dmo; for oxynil herbicide tolerance: bxn; for sulfonylurea herbicide tolerance: zm-hra, csr1-2, gm-hra and S4-HrA; for ALS inhibitor tolerance: csr1-2; and for HPPD inhibitor tolerance: hppdPF, W336 and avhppd-03.

[00174] Transgenic maize events comprising herbicide tolerance genes include, but are not limited to, DAS40278, MON801, MON802, MON809, MON810, MON832, MON87411, MON87419, MON87427, MON88017, MON89034, NK603, GA21, MZHG0JG, HCEM485, VCO-01981-5, 676, 678, 680, 33121, 4114, 59122, 98140, Bt10, Bt176, CBH351, DBT418, DLL25, MS3, MS6, MZIR098, T25, TC1507 and TC6275. Transgenic soybean events comprising herbicide tolerance genes include, but are not limited to, GTS 40-3-2, MON87705, MON87708, MON87712, MON87769, MON89788, A2704-12, A2704-21, A5547-127, A5547-35, DP356043, DAS44406-6, DAS68416-4, DAS81419-2, GU262, SYHT0H2, W62, W98, FG72, and CV127. Transgenic cotton events comprising herbicide tolerance genes include, but are not limited to, 19-51a, 31707, 42317, 81910, 281-24-236, 3006-210-23, BXN10211, BXN10215, BXN10222, BXN10224, MON1445, MON1698, MON88701, MON88913, GHB119, GHB614, LLCotton25, T303-3 and T304-40. Transgenic canola events comprising herbicide tolerance genes are, for example, but not limited to, MON88302, HCR-1, HCN10, HCN28, HCN92, MS1, MS8, PHY14, PHY23, PHY35, PHY36, RF1, RF2 and RF3.

[00175] Transgenes to provide insect resistance are preferentially toxin genes from Bacillus spp. and their synthetic variations, such as cry1A, cry1Ab, cry1Ab-Ac, cry1Ac, cry1A.105, cry1F, cry1Fa2, cry2Ab2, cry2Ae, mcry3A, ecry3.1Ab, cry3Bb1, cry34Ab1, cry35Ab1, cry9C, Petition 870250083202, dated 09 / 16 / 2025, pp. 216 / 317 65 / 159 vip3A(a) and vip3Aa20. In addition, plant-derived transgenes can be used, such as genes encoding protease inhibitors like CpTI and pinlI. Another approach uses transgenes like dvsnf7 to produce double-stranded RNA in plants.

[00176] Transgenic maize events comprising genes for insecticidal proteins or double-stranded RNA include, but are not limited to, Bt10, Bt11, Bt176, MON801, MON802, MON809, MON810, MON863, MON87411, MON88017, MON89034, 33121, 4114, 5307, 59122, TC1507, TC6275, CBH-351, MIR162, DBT418, and MZIR098. Transgenic soybean events comprising genes for insecticidal proteins include, but are not limited to, MON87701, MON87751, and DAS-81419. Transgenic cotton events comprising genes for insecticidal proteins include, but are not limited to, SGK321, MON531, MON757, MON1076, MON15985, 31707, 31803, 31807, 31808, 42317, BNLA-601, Event1, COT67B, COT102, T303-3, T304-40, GFM Cry1A, GK12, MLS 9124, 281-24-236, 3006-210-23, GHB119, and SGK321.

[00177] Crops with increased production were created using the athb17 transgene (e.g., maize event MON87403) or bbx32 (e.g., soybean event MON87712).

[00178] Cultivated plants comprising modified oil content were created using the transgenes: gm-fad2-1, Pj.D6D, Nc.Fad3, fad2-1A and fatb1-A (e.g., soybean events 260-05, MON87705 and MON87769).

[00179] Tolerance to abiotic conditions, such as drought, was created using the cspB transgene (maize event MON87460) and Hahb-4 (soybean event IND-00410-5).

[00180] Traits are often combined through the combination of genes in a transformation event or Petition 870250083202, dated 09 / 16 / 2025, pp. 217 / 317 66 / 159 combination of different events during the cultivation process, resulting in a cultivated plant with accumulated characteristics. Preferred combinations of characteristics are combinations of tolerance characteristics to different groups of herbicides, combinations of tolerance to different types of insects, particularly tolerance to lepidopteran and coleopteran insects, combinations of herbicide tolerance with one or more types of insect resistance, combinations of herbicide tolerance with higher yield, as well as combinations of herbicide tolerance and tolerance to abiotic conditions.

[00181] Plants comprising singular or accumulated characteristics, as well as the genes and events that provide these characteristics, are well known in the art. Detailed information on mutagenized or integrated genes and corresponding events is available, for example, through the websites of the organizations "International Service for the Acquisition of Agri-biotech Applications (ISAAA)" (http: / / www.isaaa.org / gmapprovaldatabase) and "Center for Environmental Risk Assessment (CERA)" (http: / / cera-gmc.org / GMCropDatabase). Further information on specific events and methods for detecting them can be found for the canola events MS1, MS8, RF3, GT73, MON88302 and KK179 in WO 01 / 031042, WO 01 / 041558, WO 02 / 036831, WO 11 / 153186 and WO 13 / 003558; for the cotton events MON1445, MON15985, MON531 (MON15985), LLCotton25, MON88913, COT102, 281-24-236, 3006-210-23, COT67B, GHB614, T304-40, GHB119, MON88701 and 81910 em WO 02 / 034946, WO 02 / 100163, WO 03 / 013224, WO 04 / 072235, WO 04 / 039986, WO 05 / 103266, WO 06 / 128573, WO 07 / 017186, WO 08 / 122406, WO 08 / 151780, WO 12 / 134808 and WO 13 / 112527; for the wool events GA21, MON810, DLL25, TC1507, MON863, MIR604, LY038, MON88017, 3272, 59122, NK603, MIR162, MON89034, 98140, 32138, MON87460, 5307 , 4114 , MON87427 , DAS40278 , MON87411 , 33121 , MON87403 and MON87419 in WO 98 / 044140 , 1999 . Petition 870250083202, 09 / 16 / 2025, p. 218 / 3 67 / 1 US 02 / 102582, US 03 / 126634, WO 04 / 099447, WO 04 / 011601, WO 05 / 103301, WO 05 / 061720, WO 05 / 059103, WO 06 / 098952, WO 06 / 039376, US 2007 / 292854, YOU 07 / 142840, YOU 07 / 140256, YOU 08 / 112019, YOU 09 / 103049, YOU 09 / 111263, YOU 10 / 077816, YOU 11 / 084621, YOU 11 / 062904, THEY 11 / 022469, WO 13 / 169923, WO 14 / 116854, WO 15 / 053998 and WO 15 / 142571; for potato events E12, F10, J3, J55, V11, X17 and Y9 are WO 14 / 178910, WO 14 / 178913, WO 14 / 178941, WO 14 / 179231, WO 16 / 16 / 0 WO 17 / 062825; for rice events LLRICE06, LLRICE601 and LLRICE62 in WO 00 / 026345 and WO 00 / 026356; and for soybean events H7-1, MON89788, A2704-12, A5547-127, DP305423, DP356043, MON87701, MON87769, CV127, MON87705, DAS7478,MON,8-16 SYHT0H2, DAS81419, DAS81419 x DAS44406-6 and MON87751 were WO 04 / 074492, WO 06 / 130436, WO 06 / 108674, WO 06 / 108675, WO 08 / 054747, WO 08 / 002872, WO 09 / 0646152, WO 820 / 1, WO 820,0646152 10 / 037016, WO 11 / 066384, WO 11 / 034704, WO 12 / 051199, WO 12 / 082548, WO 13 / 016527, WO 13 / 016516 and WO 14.235 / 2

[00182] The use of compounds I and their compositions, respectively, on cultivated plants may result in effects that are specific to cultivated plants comprising a specific transgene or event. These effects may involve alterations in growth behavior or modified resistance to biotic or abiotic stress factors. These effects may particularly include increased yield, increased resistance or tolerance to insects, nematodes, fungi, bacteria, mycoplasma, viral pathogens or viroids, as well as early vigor, early or delayed ripening, cold or heat tolerance, in addition to modified amino acid or fatty acid content or spectrum.

[00183] Compounds I and their compositions, respectively, are particularly suitable for controlling the agents Petition 870250083202, dated 09 / 16 / 2025, pp. 219 / 317 68 / 159 causal factors of plant diseases follow.

[00184] Albugo spp. (white rust) in ornamental plants, vegetables (e.g., A. candida) and sunflower (e.g., A. tragopogonis); Alternaria spp. (Alternaria leaf spot) in vegetables (e.g., A. dauci or A. porri), canola (A. brassicicola or brassicae), beetroot (A. tenuis), fruits (e.g., A. grandis), rice, soybeans, potatoes and tomatoes (e.g., A. solani, A. grandis or A. alternata), tomatoes (e.g., A. solani or A. alternata) and wheat (e.g., A. triticina); Aphanomyces spp. in beetroot and vegetables; Ascochyta spp. in cereals and vegetables, such as A. tritici (anthracnose) in wheat and A. hordei in barley; Aureobasidium zeae (syn. Kapatiella zeae) in maize; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), such as southern leaf rust (D. maydis) or northern leaf rust (B. zeicola) in maize, as spot spots (B. sorokiniana) in cereals and, for example, B.oryzae in rice and grass; Blumeria (formerly Erysiphe) graminis (powder mildew) in cereals (e.g., in wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: gray mold) in fruits and berries (e.g., strawberries), vegetables and greens (e.g., lettuce, carrots, celery, and cabbage); B. squamosa or B. allii in onion families), canola, ornamental plants (e.g., B. elliptica), grapes, forest plants, and wheat; Bremia lactucae (downy mildew) in lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) in broadleaf trees and pines, such as C. ulmi (Dutch elm disease) in elms; Cercospora spp. (Cercospora leaf spots) in maize (e.g., gray leaf spot: C. zeae-maydis), rice, beet (e.g., C. beticola), sugarcane, legumes, coffee, soybeans (e.g., C. sojina or C. kikuchii) and rice; Cladobotryum (syn. Dactylium) spp. (e.g., C.mycophilum, formerly Dactylium dendroides, teleomorph: Nectria albertinii, Nectria rosella syn. Hypomyces rosellus) in mushrooms; Cladosporium spp. in tomatoes (for example, C. fulvum:. Petition 870250083202, dated 16 / 09 / 2025, p. 220 / 317 69 / 159 leaf mold) and cereals, such as C. herbarum (black spike) in wheat; Claviceps purpurea (ergot) in cereals; Cochliobolus (anamorph: Helminthosporium de Bipolaris) spp. (leaf spots) in maize (C. carbonum), cereals (e.g., C. sativus, anamorph: B. sorokiniana) and rice (e.g., C. miyabeanus, anamorph: H. oryzae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) in cotton (e.g., C. gossypii), maize (e.g., C. graminicola: anthracnose stem rot), soft fruits, potatoes (e.g., C. coccodes: black spots), beans (e.g., C. lindemuthianum), soybeans (e.g., C. truncatum or C. gloeosporioides), legumes (e.g., C. lagenarium or C. capsici), fruits (e.g., C. acutatum), coffee (e.g., C. coffeanum or C. kahawae), and C. gloeosporioides in various producing plants; Corticium spp., e.g., C.sasakii (sheath rust) in rice; Corynespora cassiicola (leaf spots) in soybeans, cotton, and ornamental plants; Cycloconium spp., such as C. oleaginum in olive trees; Cylindrocarpon spp. (e.g., fruit tree canker or young vine rot, teleomorph: Nectria or Neonectria spp.) in fruit trees, vines (e.g., C. liriodendri, teleomorph: Neonectria liriodendri: black foot disease), and ornamental plants; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) in soybeans; Diaporthe spp., such as D. phaseolorum (rot) in soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyrenophora) spp. in corn, cereals such as barley (e.g., D. teres, liquid spot) and wheat (e.g., D. triticirepentis: brown spot), rice and grass; Esca (death, apoplexy) in vines, caused by Formitiporia (syn. Phellinus) punctata, F.mediterranea, Phaeomoniella chlamydospora (formerly Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and / or Botryosphaeria obtusa; Elsinoe spp. in pomes (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf soot) in rice; Petition 870250083202, dated 09 / 16 / 2025, pp. 221 / 317 70 / 159 Epicoccum spp. (black fungus) in wheat; Erysiphe spp. (powdery mildew) in beetroot (E. betae), legumes and vegetables (e.g., E. pisi), such as pumpkins (e.g., E. cichoracearum), cabbage and canola (e.g., E. cruciferarum); Eutypa lata (Eutypa canker or death, anamorph: Cytosporina lata, syn. Libertella blepharis) in fruit trees, vines and ornamental plants; Exserohilum (syn. Helminthosporium) spp. in maize (e.g., E. turcicum); Fusarium (teleomorph: Gibberella) spp. (wilting, root or stem rot) in various plants, such as F. graminearum or F. culmorum (root rot, scarring or head rust) in cereals (such as wheat or barley), F. oxysporum in tomatoes, F. solani (formerly sp. glycines, now syn. F. virguliforme), F. tucumaniae and F. brasiliense, each causing sudden death syndrome in soybeans, and F.verticillioides in maize; Gaeumannomyces graminis (foot rot) in cereals (such as wheat or barley) and maize; Gibberella spp. in cereals (such as G. zeae) and rice (e.g., G. fujikuroi: Bakanae disease); Glomerella cingulata in vines, pomes and other plants and G. gossypii in cotton; grain spot complex in rice; Guignardia bidwellii (black spot) in vines; Gymnosporangium spp. in rosaceae and juniper plants, such as G. sabinae (rust) in pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) in maize, cereals, potatoes and rice; Hemileia spp., such as H. vastatrix (coffee leaf rust) in coffee; Isariopsis clavispora (syn. Cladosporium vitis) in vineyards; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) in soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow fungus) in cereals (e.g., wheat or barley); Microsphaera diffusa (powdery mildew) in soybeans; Monilinia spp., such as M. laxa, M.fructicola and M. fructigena (syn. Monilia spp.: branch and flower rust, brown rot) on drupes and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and peanuts, such as M. graminicola (anamorph: Zymoseptoria tritici,. Petition 870250083202, dated 09 / 16 / 2025, pp. 222 / 317 71 / 159 previously Septoria tritici (Septoria rust) in wheat or M. fijiensis (syn. Pseudocercospora fijiensis: black Sigatoka disease) and M. musicola in bananas, M. arachidicola (syn. M. arachidis or Cercospora arachidis), M. berkeleyi in peanuts, M. pisi in peas and M. brassiciola in brassica; Peronospora spp. (downy mildew) in cabbage (e.g., P. brassicae), canola (e.g., P. parasitica), onion (e.g., P. destructor), tobacco (P. tabacina) and soybean (e.g., P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybean; Phialophora spp., such as in vines (e.g., P. tracheiphila and P. tetraspora) and soybeans (e.g., P. gregata: stem rot); Phoma lingam (syn. Leptosphaeria biglobosa and L. maculans: root and stem rot) in canola and cabbage, P. betae (root rot, leaf spots and rot) in beetroot and P. zeae-maydis (syn. Phyllostica zeae) in maize; Phomopsis spp.in sunflower, grapevines (e.g., P. viticola: grapevine escoriosis) and soybeans (e.g., stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) in maize; Phytophthora spp. (wilting, root, leaf, fruit and stem root) in various plants such as paprika and pumpkin (e.g., P. capsici), soybeans (e.g., P. megasperma, syn. P. sojae), potatoes and tomatoes (e.g., P. infestans: later rust) and broadleaf trees (e.g., P. ramorum: oak sudden death); Plasmodiophora brassicae (cabbage clubroot) in cabbage, canola, radish and other plants; Plasmopara spp., such as P. viticola (grape downy mildew) in grapevines and P. halstedii in sunflower; Podosphaera spp. (powdery mildew) in rosaceous plants, hops, pomes and soft fruits (e.g., P. leucotricha in apples) and pumpkin (P. xanthii); Polymyxa spp., for example, in cereals such as barley and wheat (P. graminis) and beet (P.betae) and viral diseases transmitted in this way; Pseudocercosporella herpotrichoides (syn. Oculimacula yallundae and O. acuformis: eye spot, teleomorph: Tapesia. Petition 870250083202, dated 09 / 16 / 2025, pp. 223 / 317 72 / 159 yallundae) in cereals, such as wheat or barley; Pseudoperonospora (downy mildew) in various plants, such as P. cubensis in pumpkins or P. humili in hops; Pseudopezicula tracheiphila (red fire disease, anamorph: Phialophora) in vines; Puccinia spp. (rusts) in various plants, such as P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (black or stem rust) or P. recondita (brown or leaf rust) in cereals, such as wheat, barley or rye, P. kuehnii (orange rust) in sugar cane and P. asparagi in asparagus; Pyrenopeziza spp., such as P. brassicae in canola; Pyrenophora (anamorph: Drechslera) tritici-repentis (brown spot) in wheat or P. teres (liquid spot) in barley; Pyricularia spp., such as P. oryzae (teleomorph: Magnaporthe grisea, brown spot of rice) in rice and P. grisea in grass and cereals; Pythium spp.(Rot) in grass, rice, corn, wheat, cotton, canola, sunflower, soybean, beet, vegetables and various other plants (e.g., P. ultimum or P. aphanidermatum) and P. oligandrum in mushrooms; Ramularia spp., such as R. collo-cygni (Ramularia leaf spots, physiological leaf spots) in barley, R. areola (teleomorph: Mycosphaerella areola) in cotton and R. beticola in beet; Rhizoctonia spp. in cotton, rice, potato, grass, corn, canola, potato, beet, vegetables and various other plants, such as R. solani (root and stem rot) in soybean, R. solani (sheath rust) in rice or R. cerealis (Rhizoctonia spring rust) in wheat or barley; Rhizopus stolonifer (black fungus, soft rot) in strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis and R. commune (scorch) in barley, rye, and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) in rice; Sclerotinia spp.(stem rot or white fungus) in legumes (S. minor and S. sclerotiorum) and field crops such as canola, sunflower (e.g., S. sclerotiorum) and soybean, S. rolfsii (syn. Athelia rolfsii) in soybean, peanut,. Petition 870250083202, dated 09 / 16 / 2025, pp. 224 / 317 73 / 159 vegetables, corn, cereals and ornamental plants; Septoria spp. in various plants, such as S. glycines (brown spot) in soybeans, S. tritici (syn. Zymoseptoria tritici, Septoria rust) in wheat and S. (syn. Stagonospora) nodorum (Stagonospora rust) in cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) in vines; Setosphaeria spp. (leaf rust) in corn (e.g., S. turcicum, syn. Helminthosporium turcicum) and grass; Sphacelotheca spp. (soot) in corn (e.g., S. reiliana, syn. Ustilago reiliana: head soot), sorghum and sugarcane; Sphaerotheca fuliginea (syn. Podosphaera xanthii: powder mildew) in pumpkins; Spongospora subterranea (dust scar) in potatoes and viral diseases transmitted in this way; Stagonospora spp. in cereals, such as S. nodorum (Stagonospora spot, teleomorph: Leptosphaeria (syn. Phaeosphaeria) nodorum syn.Septoria nodorum) in wheat; Synchytrium endobioticum in potatoes (potato wart disease); Taphrina spp., such as T. deformans (leaf curl disease) in peaches and T. pruni (plum pocket) in plums; Thielaviopsis spp. (black root rot) in tobacco, pomes, vegetables, soybeans, and cotton, such as T. basicola (syn. Chalara elegans); Tilletia spp. (common smut or foul-smelling soot) in cereals, such as T. tritici (syn. T. caries, wheat smut) and T. controversa (dwarf smut) in wheat; Trichoderma harzianum in mushrooms; Typhula incarnata (grey snow mold) in barley or wheat; Urocystis spp., such as U. occulta (stem soot) in rye; Uromyces spp. (rust) in vegetables, such as beans (e.g., U. appendiculatus, syn. U. phaseoli), beetroot (e.g., U. betae or U. beticola) and in legumes (e.g., U. vignae, U. pisi, U. viciae-fabae and U. fabae); Ustilago spp. (loose soot) in cereals (e.g., U. nuda and U.avaenae), corn (e.g., U. maydis: corn soot) and sugarcane; Venturia spp. (scar) on apples (e.g., V. inaequalis) and pears; Verticillium spp. (wilt) on various plants, such as fruits and ornamental plants, vines, soft fruits,. Petition 870250083202, dated 09 / 16 / 2025, pp. 225 / 317 74 / 159 vegetables and field crops, such as V. longisporum in canola, V. dahliae in strawberries, canola, potatoes and tomatoes, and V. fungicola in mushrooms; and Zymoseptoria tritici in cereals.

[00185] Compounds I and their compositions, respectively, are particularly suitable for the control of the following plant disease causal agents: rust in soybeans and cereals (e.g., Phakopsora pachyrhizi and P. meibomiae in soybeans; Puccinia tritici and P. striiformis in wheat); mildew in specialty producing plants, soybeans, canola and sunflowers (e.g., Botrytis cinerea in strawberries and vines, Sclerotinia sclerotiorum, S. minor and S. rolfsii in canola, sunflowers and soybeans); Fusarium diseases in cereals (e.g., Fusarium culmorum and F. graminearum in wheat); downy mildew in specialty producing plants (e.g., Plasmopara viticola in vines and Phytophthora infestans in potatoes); Powdery mildew in specialty crop-producing plants and cereals (e.g., Uncinula necator in vines, Erysiphe spp. in various specialty crop-producing plants, and Blumeria graminis in cereals); and leaf spots in cereals, soybeans, and maize (e.g., Septoria tritici and S.nodorum in cereals, S. glycines in soybeans, and Cercospora spp. in corn and soybeans.

[00186] According to one embodiment, compounds IA-1.1aB-1 to IA-1.1aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00187] According to one embodiment, compounds IA-2.1aB-1 to IA-2.1aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00188] According to one embodiment, compounds IA-3.1aB-1 to IA-3.1aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00189] According to one realization, compounds IA-4.1aB-1 Petition 870250083202, dated 09 / 16 / 2025, pp. 226 / 317 75 / 159 and IA-4.1aB-180 are particularly suitable for controlling the causal agents of plant diseases according to list Z.

[00190] According to one embodiment, compounds IA-5.1aB-1 to IA-5.1aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00191] According to one embodiment, compounds IA-6.1aB-1 to IA-6.1aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00192] According to one embodiment, compounds IA-1.2aB-1 to IA-1.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00193] According to one embodiment, compounds IA-2.2aB-1 to IA-2.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00194] According to one embodiment, compounds IA-3.2aB-1 to IA-3.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00195] According to one embodiment, compounds IA-4.2aB-1 to IA-4.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00196] According to one embodiment, compounds IA-5.2aB-1 to IA-5.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00197] According to one embodiment, compounds IA-6.2aB-1 to IA-6.2aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00198] According to one embodiment, compounds IA-1.3aB-1 to IA-1.3aB-180 are particularly suitable for controlling the agents Petition 870250083202, dated 09 / 16 / 2025, pp. 227 / 317 76 / 159 causal agents of plant diseases according to list Z.

[00199] According to one embodiment, compounds IA-2.3aB-1 to IA-2.3aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00200] According to one embodiment, compounds IA-3.3aB-1 to IA-3.3aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00201] According to one embodiment, compounds IA-4.3aB-1 to IA-4.3aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00202] According to one embodiment, compounds IA-5.3aB-1 to IA-5.3aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00203] According to one embodiment, compounds IA-6.3aB-1 to IA-6.3aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00204] According to one embodiment, compounds IA-1.4aB-1 to IA-1.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00205] According to one embodiment, compounds IA-2.4aB-1 to IA-2.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00206] According to one embodiment, compounds IA-3.4aB-1 to IA-3.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00207] According to one embodiment, compounds IA-4.4aB-1 to IA-4.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z. Petition 870250083202, dated 09 / 16 / 2025, pp. 228 / 317 77 / 159

[00208] According to one embodiment, compounds IA-5.4aB-1 to IA-5.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00209] According to one embodiment, compounds IA-6.4aB-1 to IA-6.4aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00210] According to one embodiment, compounds IA-1.5aB-1 to IA-1.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00211] According to one embodiment, compounds IA-2.5aB-1 to IA-2.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00212] According to one embodiment, compounds IA-3.5aB-1 to IA-3.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00213] According to one embodiment, compounds IA-4.5aB-1 to IA-4.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00214] According to one embodiment, compounds IA-5.5aB-1 to IA-5.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00215] According to one embodiment, compounds IA-6.5aB-1 to IA-6.5aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00216] According to one embodiment, compounds IA-1.6aB-1 to IA-1.6aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00217] According to one realization, compounds IA-2.6aB-1 Petition 870250083202, dated 09 / 16 / 2025, pp. 229 / 317 78 / 159 and IA-2.6aB-180 are particularly suitable for controlling the causal agents of plant diseases according to list Z.

[00218] According to one embodiment, compounds IA-3.6aB-1 to IA-3.6aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00219] According to one embodiment, compounds IA-4.6aB-1 to IA-4.6aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00220] According to one embodiment, compounds IA-5.6aB-1 to IA-5.6aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00221] According to one embodiment, compounds IA-6.6aB-1 to IA-6.6aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00222] According to one embodiment, compounds IA-1.7aB-1 to IA-1.7aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00223] According to one embodiment, compounds IA-2.7aB-1 to IA-2.7aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00224] According to one embodiment, compounds IA-3.7aB-1 to IA-3.7aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00225] According to one embodiment, compounds IA-4.7aB-1 to IA-4.7aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00226] According to one embodiment, compounds IA-5.7aB-1 to IA-5.7aB-180 are particularly suitable for controlling the agents Petition 870250083202, dated 09 / 16 / 2025, pp. 230 / 317 79 / 159 causal agents of plant diseases according to list Z.

[00227] According to one embodiment, compounds IA-6.7aB-1 to IA-6.7aB-180 are particularly suitable for controlling plant disease causal agents according to list Z.

[00228] According to one embodiment, compounds Ex-1 to Ex-92 are particularly suitable for controlling plant disease causal agents according to list Z.

[00229] List Z: Albugo spp. (white rust) in ornamental plants, vegetables (e.g., A. candida) and sunflower (e.g., A. tragopogonis); Alternaria spp. (Alternaria leaf spot) in vegetables (e.g., A. dauci or A. porri), canola (A. brassicicola or brassicae), beetroot (A. tenuis), fruits (e.g., A. grandis), rice, soybeans, potatoes and tomatoes (e.g., A. solani, A. grandis or A. alternata), tomatoes (e.g., A. solani or A. alternata) and wheat (e.g., A. triticina); Aphanomyces spp. in beetroot and vegetables; Ascochyta spp. in cereals and vegetables, such as A. tritici (anthracnose) in wheat and A. hordei in barley; Aureobasidium zeae (syn. Kapatiella zeae) in maize; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), such as southern leaf rust (D. maydis) or northern leaf rust (B. zeicola) in maize, as spot spots (B. sorokiniana) in cereals and, for example, B.oryzae in rice and grass; Blumeria (formerly Erysiphe) graminis (powder mildew) in cereals (e.g., in wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: gray mold) in fruits and berries (e.g., strawberries), vegetables and greens (e.g., lettuce, carrots, celery, and cabbage); B. squamosa or B. allii in onion families), canola, ornamental plants (e.g., B. elliptica), grapes, forest plants, and wheat; Bremia lactucae (fluffy mildew) in lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) in broadleaf trees and pines, such as C. ulmi (disease). Petition 870250083202, dated 09 / 16 / 2025, pp. 231 / 317 80 / 159 of Dutch elm) in elms; Cercospora spp. (Cercospora leaf spots) in maize (e.g., grey leaf spot: C. zeae-maydis), rice, beet (e.g., C. beticola), sugarcane, legumes, coffee, soybeans (e.g., C. sojina or C. kikuchii) and rice; Cladobotryum (syn. Dactylium) spp. (e.g., C. mycophilum, formerly Dactylium dendroides, teleomorph: Nectria albertinii, Nectria rosella syn. Hypomyces rosellus) in mushrooms; Cladosporium spp. in tomatoes (e.g., C. fulvum: leaf mildew) and cereals, such as C. herbarum (black spike) in wheat; Claviceps purpurea (purple clove) in cereals; Cochliobolus (anamorph: Helminthosporium de Bipolaris) spp. (leaf spots) in maize (C. carbonum), cereals (e.g., C. sativus, anamorph: B. sorokiniana), and rice (e.g., C. miyabeanus, anamorph: H. oryzae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) in cotton (e.g., C. gossypii), maize (e.g., C.graminicola: stem rot (Anthracnose), soft fruits, potatoes (e.g., C. coccodes: black spots), beans (e.g., C. lindemuthianum), soybeans (e.g., C. truncatum or C. gloeosporioides), legumes (e.g., C. lagenarium or C. capsici), fruits (e.g., C. acutatum), coffee (e.g., C. coffeanum or C. kahawae) and C. gloeosporioides in various producing plants; Corticium spp., e.g., C. sasakii (sheath rust) in rice; Corynespora cassiicola (leaf spots) in soybeans, cotton, and ornamental plants; Cycloconium spp., such as C. oleaginum in olive trees; Cylindrocarpon spp. (e.g., fruit tree canker or young vine rot, teleomorph: Nectria or Neonectria spp.) in fruit trees, vines (e.g., C. liriodendri, teleomorph: Neonectria liriodendri: black foot disease) and ornamental plants; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) in soybeans; Diaporthe spp., such as D. phaseolorum (rot) in soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyrenophora) spp. in corn, cereals, such as. Petition 870250083202, dated 09 / 16 / 2025, pp. 232 / 317 81 / 159 barley (e.g., D. teres, liquid spot) and wheat (e.g., D. triticirepentis: brown spot), rice and grass; Esca (death, apoplexy) in vines, caused by Formitiporia (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella chlamydospora (formerly Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and / or Botryosphaeria obtusa; Elsinoe spp. in pomes (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf sooty mold) in rice; Epicoccum spp. (black fungus) in wheat; Erysiphe spp. (powdery mildew) in beetroot (E. betae), legumes and vegetables (e.g., E. pisi), such as pumpkins (e.g., E. cichoracearum), cabbage and canola (e.g., E. cruciferarum); Eutypa lata (Eutypa canker or death, anamorph: Cytosporina lata, syn. Libertella blepharis) in fruit trees, vines and ornamental plants; Exserohilum (syn. Helminthosporium) spp. in maize (e.g., E.turcicum); Fusarium (teleomorph: Gibberella) spp. (wilting, root or stem rot) in various plants, such as F. graminearum or F. culmorum (root rot, scar or head rust) in cereals (such as wheat or barley), F. oxysporum in tomatoes, F. solani (formerly sp. glycines, now syn. F. virguliforme), F. tucumaniae and F. brasiliense, each causing sudden death syndrome in soybeans, and F. verticillioides in maize; Gaeumannomyces graminis (foot blight) in cereals (such as wheat or barley) and maize; Gibberella spp. in cereals (such as G. zeae) and rice (e.g., G. fujikuroi: Bakanae disease); Glomerella cingulata in vines, pomes and other plants and G. gossypii in cotton; grain spot complex in rice; Guignardia bidwellii (black spot) in vines; Gymnosporangium spp. in rosaceous and juniper plants, such as G. sabinae (rust) in pears; Helminthosporium spp. (syn.Drechslera, teleomorph: Cochliobolus) in maize, cereals, potatoes and rice; Hemileia spp., such as H. vastatrix (coffee leaf rust) in coffee; Isariopsis clavispora (syn. Cladosporium vitis) in vines; Petition 870250083202, dated 09 / 16 / 2025, pp. 233 / 317 82 / 159 Macrophomina phaseolina (syn. phaseoli) (root and stem rot) in soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow fungus) in cereals (e.g., wheat or barley); Microsphaera diffusa (powdery mildew) in soybeans; Monilinia spp., such as M. laxa, M. fructicola, and M. fructigena (syn. Monilia spp.: branch and flower rust, brown rot) in drupes and other rosaceous plants; Mycosphaerella spp. in cereals, bananas, soft fruits and peanuts, such as M. graminicola (anamorph: Zymoseptoria tritici, formerly Septoria tritici, Septoria rust) in wheat or M. fijiensis (syn. Pseudocercospora fijiensis: black Sigatoka disease) and M. musicola in bananas, M. arachidicola (syn. M. arachidis or Cercospora arachidis), M. berkeleyi in peanuts, M. pisi in peas and M. brassiciola in brassica; Peronospora spp. (downy mildew) in cabbage (e.g., P. brassicae), canola (e.g., P. parasitica), onion (e.g., P.destructor), tobacco (P. tabacina) and soybean (e.g., P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybean; Phialophora spp., such as in vines (e.g., P. tracheiphila and P. tetraspora) and soybean (e.g., P. gregata: stem rot); Phoma lingam (syn. Leptosphaeria biglobosa and L. maculans: root and stem rot) in canola and cabbage, P. betae (root rot, leaf spots and rot) in beet and P. zeae-maydis (syn. Phyllostica zeae) in maize; Phomopsis spp. in sunflower, grapevines (e.g., P. viticola: grapevine escoriosis) and soybeans (e.g., stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) in maize; Phytophthora spp. (wilting, root, leaf, fruit and stem root) in various plants, such as paprika and pumpkin (e.g., P. capsici), soybeans (e.g., P. megasperma, syn. P. sojae), potatoes and tomatoes (e.g., P.infestans: later rust) and broad-leaved trees (e.g., P. ramorum: oak sudden death); Plasmodiophora brassicae (cabbage clubroot) in cabbage, canola, radish, and... Petition 870250083202, dated 09 / 16 / 2025, pp. 234 / 317 83 / 159 other plants; Plasmopara spp., such as P. viticola (grape downy mildew) in vineyards and P. halstedii in sunflowers; Podosphaera spp. (powder mildew) in rosaceae, hops, pomes and soft fruits (e.g., P. leucotricha in apples) and pumpkin (P. xanthii); Polymyxa spp., for example, in cereals such as barley and wheat (P. graminis) and beetroot (P. betae) and viral diseases transmitted in this way; Pseudocercosporella herpotrichoides (syn. Oculimacula yallundae and O. acuformis: eye spot, teleomorph: Tapesia yallundae) in cereals such as wheat or barley; Pseudoperonospora (downy mildew) in various plants, such as P. cubensis in pumpkins or P. humili in hops; Pseudopezicula tracheiphila (red fire disease, anamorph: Phialophora) in vineyards; Puccinia spp. (rusts) in various plants, such as P. triticina (brown or leaf rust), P. striiformis (stripes or yellow rust), P. hordei (dwarf rust), P. graminis (black or stem rust) or P.recondita (brown or leaf rust) in cereals such as wheat, barley, or rye; P. kuehnii (orange rust) in sugarcane and P. asparagi in asparagus; Pyrenopeziza spp., such as P. brassicae in canola; Pyrenophora (anamorph: Drechslera) tritici-repentis (brown spot) in wheat or P. teres (liquid spot) in barley; Pyricularia spp., such as P. oryzae (teleomorph: Magnaporthe grisea, brown spot of rice) in rice and P. grisea in grass and cereals; Pythium spp. (rot) in grass, rice, corn, wheat, cotton, canola, sunflower, soybean, beet, vegetables, and various other plants (e.g., P. ultimum or P. aphanidermatum) and P. oligandrum in mushrooms; Ramularia spp., such as R. collo-cygni (Ramularia leaf spots, physiological leaf spots) in barley, R. areola (teleomorph: Mycosphaerella areola) in cotton, and R. beticola in beet; Rhizoctonia spp.in cotton, rice, potato, grass, corn, canola, potato, beet, vegetables and various other plants, such as R. solani (root and stem rot) in soybean, R. solani (sheath rust) in rice or R. cerealis. Petition 870250083202, dated 09 / 16 / 2025, pp. 235 / 317 84 / 159 (Rhizoctonia spring rust) in wheat or barley; Rhizopus stolonifer (black fungus, soft rot) in strawberries, carrots, cabbage, vines, and tomatoes; Rhynchosporium secalis and R. commune (scorched) in barley, rye, and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) in rice; Sclerotinia spp. (stem rot or white fungus) in legumes (S. minor and S. sclerotiorum) and field crops such as canola, sunflower (e.g., S. sclerotiorum), and soybeans; S. rolfsii (syn. Athelia rolfsii) in soybeans, peanuts, legumes, maize, cereals, and ornamental plants; Septoria spp. in various plants, such as S. glycines (brown spot) in soybeans, S. tritici (syn. Zymoseptoria tritici, Septoria rust) in wheat and S. (syn. Stagonospora) nodorum (Stagonospora rust) in cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) in vines; Setosphaeria spp. (leaf rust) in maize (e.g., S. turcicum, syn.Helminthosporium turcicum) and grass; Sphacelotheca spp. (soot) in maize (e.g., S. reiliana, syn. Ustilago reiliana: head soot), sorghum, and sugarcane; Sphaerotheca fuliginea (syn. Podosphaera xanthii: powder mildew) in pumpkins; Spongospora subterranea (powder scar) in potatoes and viral diseases transmitted in this way; Stagonospora spp. in cereals, such as S. nodorum (Stagonospora spot, teleomorph: Leptosphaeria (syn. Phaeosphaeria) nodorum syn. Septoria nodorum) in wheat; Synchytrium endobioticum in potatoes (potato wart disease); Taphrina spp., such as T. deformans (leaf curl disease) in peaches and T. pruni (plum pocket) in plums; Thielaviopsis spp. (black root rot) in tobacco, pomes, legumes, soybeans, and cotton, such as T. basicola (syn. Chalara elegans); Tilletia spp. (common smut or foul-smelling soot) in cereals, such as T. tritici (syn. T. caries, wheat smut) and T.controversial (dwarf smut) in wheat; Trichoderma harzianum in mushrooms; Typhula incarnata (grey snow mold) in barley or wheat; Urocystis spp., such as U. occulta (stem soot) in rye; Uromyces spp. Petition 870250083202, dated 09 / 16 / 2025, pp. 236 / 317 85 / 159 (rust) in vegetables, such as beans (e.g., U. appendiculatus, syn. U. phaseoli), beetroot (e.g., U. betae or U. beticola) and legumes (e.g., U. vignae, U. pisi, U. viciae-fabae and U. fabae); Ustilago spp. (loose soot) in cereals (e.g., U. nuda and U. avaenae), maize (e.g., U. maydis: maize soot) and sugarcane; Venturia spp. (scar) in apples (e.g., V. inaequalis) and pears; Verticillium spp. (wilt) in various plants, such as fruits and ornamental plants, vines, soft fruits, vegetables and field crops, such as V. longisporum in canola, V. dahliae in strawberries, canola, potatoes and tomatoes and V. fungicola in mushrooms; and Zymoseptoria tritici in cereals.

[00230] Compounds I and their compositions, respectively, are also suitable for controlling harmful microorganisms in the protection of crops or stored products and in the protection of materials.

[00231] The expression "harvest or stored products" is understood to indicate natural substances of plant or animal origin and their processed forms for which long-term protection is desired. Stored products of plant origin, such as stems, leaves, tubers, seeds, fruits or grains, may be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, fragmented, ground, pressed or roasted. This process is also known as post-harvest treatment. The definition of stored products also includes wood, both in the form of raw timber, such as construction timber, electricity poles and barriers, and in the form of finished articles, such as furniture or objects made of wood. Stored products of animal origin are leather, hides, furs and the like.Preferably, "stored products" is understood to mean natural substances of plant origin and their processed forms, most preferably fruits and their processed forms, such as. Petition 870250083202, dated 09 / 16 / 2025, pp. 237 / 317 86 / 159 pomes, drupes, soft fruits, citrus fruits and their processed forms, in which the application of compounds I and their compositions can also prevent undesirable effects such as rotting, discoloration or mold.

[00232] The expression "protection of materials" should be understood as indicating the protection of technical and non-living materials, such as adhesives, glues, wood, paper, cardboard, fabrics, leather, paint dispersions, plastic, cooling lubricants, fiber or fabrics against infestation and destruction by harmful microorganisms, such as fungi and bacteria.

[00233] When used for the protection of stored materials or products, the amount of active substance applied depends on the type of application area and the desired effect. The amounts normally applied for the protection of materials are 0.001 ga 2 kg, preferably 0.005 ga 1 kg, of active substance per cubic meter of material treated.

[00234] Compounds I and their compositions, respectively, can be used to improve plant health. The present invention also relates to a method of improving plant health by treating a plant, its propagation material and / or the location where the plant is growing or should grow with an effective amount of Compounds I and their compositions, respectively.

[00235] The expression "plant health" should be understood as indicating a condition of the plant and / or its products that is determined by several indicators, individually or in combination, such as yield (e.g., increased biomass and / or increased content of valuable ingredients), plant vigor (e.g., greater plant growth and / or greener leaves ("lush effect")), quality (e.g., higher content or composition of certain ingredients), and tolerance to biotic and / or abiotic stress. The indicators identified above for the health condition of a plant may be interdependent or resultant from each other. Petition 870250083202, dated 09 / 16 / 2025, pp. 238 / 317 87 / 159

[00236] Compound I is used as is or in the form of compositions for the treatment of fungi, plants, plant propagation materials such as seeds, soil, surfaces, materials or rooms to be protected against fungal attacks, with an effective amount of the active substances acting as a fungicide. Application may be carried out before or after infection of plants, plant propagation materials such as seeds, soil, surfaces, materials or rooms by fungi.

[00237] An agrochemical composition comprises an effective amount as a fungicide of a compound I. The expression "effective amount as a fungicide" indicates an amount of the composition or compounds I that is sufficient to control harmful fungi on cultivated plants or to protect stored products, crops or materials and that does not result in substantial damage to the treated plants, the treated stored products, the crops or the treated materials. This amount can vary over a wide range and depends on several factors, such as the fungal species to be controlled, the cultivated plant being treated, the crop, stored material or product, the climatic conditions and the specific compound I used.

[00238] Plant propagation materials may be treated with compounds I alone or with a composition comprising at least one compound I on a prophylactic basis, during or before planting or transplanting.

[00239] When used in plant protection, the amounts of active substances applied are, depending on the type of effect desired, from 0.001 to 2 kg per ha, preferably 0.005 to 2 kg per ha, more preferably 0.05 to 0.9 kg per ha and, particularly, 0.1 to 0.75 kg per ha.

[00240] In the treatment of plant propagation materials, such as seeds, for example, by means of dusting, coating or Petition 870250083202, dated 09 / 16 / 2025, pp. 239 / 317 88 / 159 immersion, quantities of active substance are generally required of 0.1 to 1000 g, preferably 1 to 1000 g, more preferably 1 to 100 g, preferably higher, 5 to 100 g, per 100 kg of plant propagation material (preferably seeds).

[00241] The user typically applies the agrochemical composition from a pre-dosing device, backpack sprayer, spray tank, crop-spraying aircraft, or irrigation system. Typically, the agrochemical composition is made up of water, buffer, and / or additional auxiliaries up to the desired application concentration, thus obtaining the ready-to-use spray liquid or the agrochemical composition according to the present invention. Typically, 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquid are applied per hectare of usable agricultural area.

[00242] Compounds I, their N-oxides and salts can be converted into common types of agrochemical compositions, such as solutions, emulsions, suspensions, dry powders, powders, pastes, granules, pressed powders, capsules and mixtures thereof. Examples of composition types (see also Catalogue of pesticide formulation types and international coding system, Technical Monograph No. 2, 6th edition, May 2008, CropLife International) are suspensions (e.g., SC, OD and FS), emulsifiable concentrates (e.g., EC), emulsions (e.g., EW, EO, ES and ME), capsules (e.g., CS and ZC), pastes, pellets, wettable or dry powders (e.g., WP, SP, WS, DP and DS), pressed powders (e.g., BR, TB and DT), granules (e.g., WG, SG, GR, FG, GG and MG) or insecticidal articles (e.g., LN), as well as gel formulations for the treatment of plant propagation materials such as seeds (e.g., GF).The compositions are prepared in a known manner, as described by Mollet and Grubemann, Formulation Technology, Wiley VCH, Weinheim, 2001; or by Knowles, New Developments. Petition 870250083202, dated 09 / 16 / 2025, pp. 240 / 317 89 / 159 in crop protection product formulation, Agrow Reports DS243, T&F Informa, London, 2005. The present invention also relates to agrochemical compositions comprising an auxiliary and at least one compound I.

[00243] Suitable auxiliaries are solvents, liquid vehicles, solid vehicles or fillers, surfactants, dispersants, emulsifiers, wetting agents, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesive agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, antifreeze agents, antifoaming agents, colorants, adhesives and binders.

[00244] Suitable solvents and liquid carriers are water and organic solvents, such as fractions of mineral oils with medium to high boiling points, such as kerosene and diesel oil; vegetable or animal oils; aliphatic, cyclic and aromatic hydrocarbons, such as toluene, paraffin, tetrahydronaphthalene and alkylated naphthalenes; alcohols, such as ethanol, propanol, butanol, benzyl alcohol and cyclohexanol; glycols; DMSO; ketones, such as cyclohexanone; esters, such as lactates, carbonates, fatty acid esters and gamma-butyrolactone; fatty acids; phosphonates; amines; amides, such as N-methylpyrrolidone and fatty acid dimethylamides; and mixtures thereof.

[00245] Solid vehicles or suitable cargoes are mineral earths, such as silicates, silica gel, talc, kaolin, lime, limestone, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate and magnesium oxide; polysaccharides, such as cellulose and starch; fertilizers, such as ammonium sulfate, ammonium phosphate, ammonium nitrate and ureas; and products of vegetable origin, such as cereal flour, tree bark flour, wood flour, nut shell flour and mixtures thereof.

[00246] Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes and mixtures thereof. These surfactants may be Petition 870250083202, dated 09 / 16 / 2025, pp. 241 / 317 90 / 159 used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids, or adjuvants. Examples of surfactants are listed in McCutcheon's, Vol. 1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, United States, 2008 (International Edition or North American Edition).

[00247] Suitable anionic surfactants are alkaline, alkaline-earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates and mixtures thereof. Examples of sulfonates are alkylaryl sulfonates, diphenyl sulfonates, alpha-olefin sulfonates, lignin sulfonates, oil and fatty acid sulfonates, ethoxylated alkylphenol sulfonates, alkoxylated arylphenol sulfonates, condensed naphthalene sulfonates, dodecyl and tridecylbenzene sulfonates, naphthalene and alkylnaphthalene sulfonates, sulfosuccinates or sulfosuccinamates. Examples of sulfates are sulfates of oils, fatty acids, ethoxylated alkylphenols, alcohols, ethoxylated alcohols, or fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates, carboxylated alcohols, or alkylphenol ethoxylates.

[00248] Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters that have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and / or propylene oxide may be used for alkoxylation, preferably ethylene oxide. Examples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose esters and Petition 870250083202, dated 09 / 16 / 2025, pp. 242 / 317 91 / 159 glucose or alkyl polyglycosides. Examples of polymeric surfactants are homo- or copolymers of vinyl pyrrolidone, vinyl alcohols, or vinyl acetate.

[00249] Suitable cationic surfactants are quaternary surfactants, such as quaternary ammonium compounds with one or two hydrophobic groups or salts of long-chain primary amines. Suitable amphoteric surfactants are alkylbetaines and imidazolines. Suitable block polymers are AB or ABA type block polymers comprising polyethylene oxide and polypropylene oxide blocks or ABC type block polymers comprising alkanol, polyethylene oxide and polypropylene oxide. Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkaline salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinyl amines or polyethylene amines.

[00250] Suitable adjuvants are compounds that, on their own, have negligible or no pesticidal activity and improve the biological performance of compound I on the target. Examples include surfactants, mineral or vegetable oils, and other auxiliaries. Additional examples are listed by Knowles, Adjuvants and Additives, Agrow Reports DS256, T&F Informa, UK, 2006, chapter 5.

[00251] Suitable thickeners are polysaccharides (such as xanthan gum and carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates and silicates.

[00252] Suitable bactericides are bronopol and isothiazolinone derivatives, such as alkylisothiazolinones and benzisothiazolinones.

[00253] Suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin.

[00254] Suitable antifoaming agents are silicones, long-chain alcohols and fatty acid salts.

[00255] Suitable dyes (e.g., reds, blues) Petition 870250083202, dated 09 / 16 / 2025, pp. 243 / 317 92 / 159 or greens) are pigments with low solubility in water and water-soluble dyes. Examples include inorganic dyes (such as iron oxide, titanium oxide, and iron hexacyanoferrate) and organic dyes (such as alizarin, azo, and phthalocyanine dyes).

[00256] Suitable adhesives or binders are polyvinylpyrrolidones, polyvinyl acetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes and cellulose ethers.

[00257] Agrochemical compositions generally comprise 0.01 to 95%, preferably 0.1 to 90%, more preferably 1 to 70%, and particularly 10 to 60% by weight of active substances (e.g., at least one compound I). Agrochemical compositions generally comprise 5 to 99.9%, preferably 10 to 99.9%, more preferably 30 to 99%, and particularly 40 to 90% by weight of at least one auxiliary. The active substances (e.g., compound I) are employed in a purity of 90% to 100%, preferably 95% to 100% (according to the NMR spectrum).

[00258] For the purpose of treating plant propagation materials, particularly seeds, seed treatment solutions (STS), suspoemulsions (SE), fluid concentrates (FC), dry treatment powders (DS), water-dispersible powders for spray treatment (WSP), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are commonly used. The compositions in question offer, after dilution two to ten times, active substance concentrations of 0.01 to 60% by weight, preferably 0.1 to 40%, in ready-to-use preparations. Application can be carried out before or during cultivation. The application methods of compound I and its compositions, respectively, on plant propagation material, especially seeds, include coating, covering, pelleting, dusting, and immersion, as well as methods of Petition 870250083202, dated 09 / 16 / 2025, pp. 244 / 317 93 / 159 application in planting holes. Preferably, compound I or its compositions, respectively, are applied to the plant propagation material by means of a method that does not induce germination, such as coating, pelleting, covering and dusting seeds.

[00259] Various types of oils, humectants, adjuvants, fertilizers or micronutrients and additional pesticides (such as fungicides, growth regulators, herbicides, insecticides and safety agents) may be added to Compound I or to its compositions as a premix or not up to immediately before use (tank mixing). These agents may be mixed with the compositions according to the present invention, in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.

[00260] A pesticide is generally a chemical or biological agent (such as an active pesticide ingredient, compound, composition, virus, bacteria, antimicrobial, or disinfectant) that, through its effect, prevents, incapacitates, kills, or otherwise discourages pests. Target pests may include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisances, spread disease, or are vectors of disease.The term "pesticide" also includes plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause the leaves or other foliage of plants to fall off, usually to facilitate harvesting; desiccants that promote the drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense against certain pests; safety agents that reduce the unwanted herbicidal action of pesticides on producing plants; and plant growth promoters that affect plant physiology, for example, to increase growth, biomass, plant yield, or any other quality parameter of the products that can be harvested from a plant. Petition 870250083202, dated 09 / 16 / 2025, pp. 245 / 317 94 / 159 producer.

[00261] Biopesticides have been defined as a form of pesticide based on microorganisms (bacteria, fungi, viruses, nematodes, etc.) or natural products (compounds such as metabolites, proteins, or extracts from biological or other natural sources) (US Environmental Protection Agency: http: / / www.epa.gov / pesticides / biopesticides / ). Biopesticides fall into two main classes: microbial and biochemical pesticides; 1. Microbial pesticides consist of bacteria, fungi, or viruses (and often include metabolites produced by bacteria and fungi). Entomopathogenic nematodes are also classified as microbial pesticides, although they are multicellular; 2. Biochemical pesticides are naturally occurring substances that control pests or provide other uses in plant protection as defined below, but are relatively non-toxic to mammals.

[00262] The mixture of compounds I or compositions comprising them in the form used as fungicides with other fungicides often results in the expansion of the spectrum of fungicidal activity obtained or in the prevention of the development of fungicide resistance. Furthermore, in many cases, synergistic effects are obtained (synergistic mixtures).

[00263] The following list of pesticides II, which may be used in conjunction with compounds I, is intended to illustrate possible combinations, but without limitation: A. Respiratory inhibitors: - inhibitors of complex III at the Qo site: azoxystrobin (A. 1.1), coumoxystrobin (A. 1.2), coumoxystrobin (A. 1.3), dimoxystrobin (A. 1.4), enstroburin (A. 1.5), phenaminostrobin (A. 1.6), phenoxystrobin / fluphenoxystrobin (A. 1.7), fluoxastrobin (A. 1.8), kresoxim-methyl (A. 1.9), mandestrobin (A. 1.10), Petition 870250083202, dated 09 / 16 / 2025, pp. 246 / 317 95 / 159 methominostrobin (A.1.11), orisastrobin (A.1.12), picoxistrobin (A.1.13), pyraclostrobin (A.1.14), pyramethostrobin (A.1.15), pyrooxystrobin (A.1.16), trifloxystrobin (A.1.17), 2-(2-(3-(2,6-dichlorophenyl)-1-methylalilidenoamino-oxymethyl)phenyl)-2-methóxi-imino-N-methylacetamida (A.1.18), pyribencarb (A.1.19), triclopyricarb / chlorodincarb (A.1.20), famoxadona (A.1.21), fenamidona (A.1.21), N-[2-[(1,4-dimetil-5-fenilpirazol-3-yl)oxylmetil]fenil]-N-methoxycarbamato de methyla (A.1.22), metiltetraprol (A.1.25), (Z,2E)-5-[1-(2,4-diclorofenil)pirazol-3-yl]-óxi-2metóxi-imino- N ,3-dimetilpent-3-enamida (A.1.34), (Z ,2 E )-5-[1-(4clorofenil)pirazol-3-yl]óxi-2-metóxi-imino-N ,3-dimetilpent-3-enamida (A.1.35), piriminostrobina (A.1.36), bifujunzi (A.1.37) e metil éster de ácido 2-(ortho-((2,5dimethylphenyloxymethylene)phenyl)-3-methoxyacrylate (A.1.38); - inibidores do complexo III no local Qi: ciazofamid (A.2.1), amissulbrom (A.2.2), 2-metilpropanoato de [(6 S ,7 R ,8 R )-8-benzil-3-[(3-hidróxi-4metoxipiridina-2-carbonil)amino]-6-metil-4,9-dioxo-1,5-dioxonan-7-ila] (A.2.3), fempicoxamid (A.2.4), florilpicoxamid (A.2.5) e metarilpicoxamid (A.2.6); - complex II inhibitors: benodanyl (A.3.1), benzovindiflupyr (A.3.2), bixaphen (A.3.3), boscalid (A.3.4), carboxin (A.3.5), fenfuram (A.3.6), fluopyram (A.3.7), flutolanyl (A.3.8d), flutolanil (A.3.3). furametpir (A.3.10), isofetamide (A.3.11), isopirazam (A.3.12), mepronil (A.3.13), oxycarboxin (A.3.14), penflufen (A.3.15), penthiopirad (A.3.16), pidiflumide (A.3.16), pidiflumetofen (A.3.16). sedaxane (A.3.19), teclophthalam (A.3.20), tifluzamide (A.3.21), impirfluxam (A.3.22), pyrapropoine (A.3.23), fluindapir (A.3.28), N-[2-[2-chloro-4(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-5-fluoro-1-methylpyrazol-4-carboxamide (A.3.29), (E)-2-[2-[(5-cyano-2-methylphenoxy])depthyl-2methyl]phenol (A.3.30), isoflucipram (A.3.31), 2-(difluoromethyl)-N -(1,1,3-trimethylindane-4yl)-pyridine-3-carboxamide (A.3.32), 2-(difluoromethyl)-N-[(3R)-trime-1,pyridineda4-carboxynda4- (A.3.33), 2-(difluoromethyl)-N -(3-ethyl-1,1-dimethylindane4-yl)-pyridine-3-carboxamide (A.3.34), 2-(difluoromethyl)-N -[(3 R )-3-ethyl-1,1Petition 870250083202, dated 16 / 09 / 2025, p. 247 / 317. 96 / 159 dimethylindane-4-yl]-pyridine-3-carboxamide (A.3.35), 2-(difluoromethyl)-N -(1,1dimethyl-3-propylindane-4-yl)-pyridine-3-carboxamide (A.3.36), 2-(3)-Nfluoromethyl )-(1,1-dimethyl-3-propylindane-4-yl)-pyridine-3-carboxamide (A.3.37), 2(difluoromethyl)- N -(3-isobutyl-1,1-dimethylindane-4-yl)-pyridine-3-carboxamide (A.3.3-f) -(di[di-3f) -(dimeth )-3-isobutyl-1,1 -dimethylindane-4-yl]pyridine-3carboxamide (A.3.39) and cyclobutrifluram (A.3.24); and - other respiratory inhibitors: diflumetorim (A.4.1); nitrophenyl derivatives: binapacryl (A.4.2), dinobuton (A.4.3), dinocap (A.4.4), fluazinam (A.4.5), meptyldinocap (A.4.6) and ferymzone (A.4.7); organometallic compounds: phentin sais, tais as phentin acetate (A.4.8), phentin chloride (A.4.9) or phentin hydroxide (A.4.10); ametoctradine (A.4.11); and silthiopham (A.4.12); B. Sterol biosynthesis inhibitors (SBI fungicides): - inibidores da C14 desmetilase: triazóis: azaconazol (B.1.1), bitertanol (B.1.2), bromuconazol (B.1.3), ciproconazol (B.1.4), difenoconazol (B.1.5), diniconazol (B.1.6), diniconazol-M (B.1.7), epoxiconazol (B.1.8), fembuconazol (B.1.9), fluquinconazol (B.1.10), flusilazol (B.1.11), flutriafol (B.1.12), hexaconazol (B.1.13), imibenconazol (B.1.14), ipconazol (B.1.15), metconazol (B.1.17), miclobutanil (B.1.18), oxpoconazol (B.1.19), paclobutrazol (B.1.20), penconazol (B.1.21), propiconazol (B.1.22), protioconazol (B.1.23), simeconazol (B.1.24), tebuconazol (B.1.25), tetraconazol (B.1.26), triadimefon (B.1.27), triadimenol (B.1.28), triticonazol (B.1.29), uniconazol (B.1.30), 2-(2,4difluorofenil)-1,1 -difluoro-3-(tetrazol-1 -il)-1 -[5-[4-(2,2,2-trifluoroetóxi)fenil]-2piridil]propan-2-ol (B.1.31), 2-(2,4-difluorofenil)-1,1 -difluoro-3-(tetrazol-1 -il)-1 -[5[4-(trifluorometóxi)fenil]-2-piridil]propan-2-ol (B.1.32), fluoxitioconazol (B.1.33), ipfentrifluconazol (B.1.37), mefentrifluconazole (B.1.38), (2 R )-2-[4-(4-chlorophenoxy)2-(trifluoromethyl)phenyl]-1 -(1,2,4-triazol-1 -yl)propan-2-ol, (2 S )-2-[4-(4-chlorophenoxy)-2(trifluoromethyl)phenyl]-1 -(1,2,4-triazol-1 -yl)propan-2-ol and 2-(chloromethyl)-2-methyl-5-(pPetição 870250083202, de 16 / 09 / 2025, pág. 248 / 317. 97 / 159 tolylmethyl)-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol (B.1.43); imidazois: imazalil (B.1.44), pefurazoate (B.1.45), prochlorase (B.1.46) and triflumizol (B.1.47); pyrimidines, pyridines and piperazines: phenarimol (B.1.49), pyriphenox (B.1.50), triphorin (B.1.51), [3-(4-chloro-2-fluorophenyl)-5-5-(2,4-difluorophenyl)isoxazol-4-2-ylpyrid [B.3.3]-( 4-[[6-[2-(2,4-difluorophenyl)-1,1 -difluoro-2-hydroxy-3-(1,2,4triazol-1 -yl)propyl]-3-pyridyl]oxy]benzonitrile (B.1.53)trilate, 2-[6-[6-31-methylphenol(B.1.53) -(1,2,4-triazol-1 -yl)propan-2-ol (B.1.54), 2-[6-(4chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1 -(1,2,4-triazol-1 -yl)propan-2-ol (B.1.4-triazol-2-ol). 2[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)methyl propanoate (B.1.56) and methyl acid 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol1-yl)propanoic (B.1.57); - Delta-14-reductase inhibitors: aldimorph (B.2.1), dodemorph (B.2.2), dodemorph acetate (B.2.3), phenpropimorph (B.2.4), tridemorph (B.2.5), phenpropidine (B.2.6), piperaline (B.2.7) and spiroxamine (B.2.8); - 3-keto reductase inhibitors: fenhexamid (B.3.1); and - other inhibitors of sterol biosynthesis: chlorphenimazole (B.4.1); C. Inhibitors of nucleic acid synthesis: - Phenylamides or acyl amino acid fungicides: benalaxyl (C.1.1), benalaxyl-M (C.1.2), chiralaxyl (C.1.3), metalaxyl (C.1.4), metalaxyl-M (C.1.5), ofurace (C.1.6) and oxadixyl (C.1.7); and - other inhibitors of nucleic acid synthesis: himexazole (C.2.1), octilinone (C.2.2), oxolinic acid (C.2.3), bupirimate (C.2.4), 5-fluorocytosine (C.2.5), 5-fluoro-2-(p-tolylmethoxy)pyrimidin-4-amine (C.2.6), 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine (C.2.7) and 5-fluoro-2-(4-chlorophenylmethoxy)pyrimidin-4-amine (C.2.8); D. inhibits cellular and cytological division: - tubulin inhibitors: benomyl (D.1.1), carbendazim (D.1.2), Petition 870250083202, 16 / 09 / 2025, pág. 249 / 317 98 / 159 fuberidazol (D.1.3), thiabendazol (D.1.4), thiophanate-methyl (D.1.5); pyridaclomethyla (D.1.6), N-ethyl-2-[(3-ethynyl-8-methyl-6-quinolyl)óxi]butanamida (D.1.8), N-ethyl-2-[(3ethynyl-8-methyl-6-quinolyl)óxi]-2-methylsulfanylacetamida (D.1.9), 2-[(3-ethynyl-8-methyl-6quinolyl)óxi]-N -(2-fluoroethyl)butanamida (D.1.10), 2-[(3-ethynyl-8-methyl-6quinolyl)óxi]-N -(2-fluoroethyl)-2-methoxyacetamida (D.1.11), 2-[(3-ethynyl-8-methyl-6quinolyl)óxi]-N -propylbutanamide (D.1.12), 2-[(3-ethynyl-8-methyl-6-quinolyl)óxi]-2methoxy-N -propylacetamida (D.1.13), 2-[(3-ethynyl-8-methyl-6-quinolyl)óxi]-2methylsulfanyl-N-propylacetamida (D.1.14), 2-[(3-ethynyl-8-methyl-6-quinolyl)óxi]-N-(2fluoroethyl)-2-methylsulfanylacetamida (D.1.15) and 4-(2-bromo-4-fluorophenyl)-N-(2chloro-6-fluorophenyl)-2,5-dimethylpyrazol-3-amine (D.1.16); And - other inhibitors of cell division: dietofencarb (D.2.1), etaboxam (D.2.2), pencicuron (D.2.3), fluopicolide (D.2.4), zoxamide (D.2.5), metrafenone (D.2.6), pyriophenone (D.2.7) and fenamacryl (D.2.8); E. Inhibitors of amino acid and protein synthesis: - inhibitors of methionine synthesis: cyprodinil (E.1.1), mepanipyrim (E.1.2) and pyrimethanil (E.1.3); and - Protein synthesis inhibitors: blasticidin-S (E.2.1), kasugamycin (E.2.2), kasugamycin hydrochloride (E.2.3), mildiomycin (E.2.4), streptomycin (E.2.5) and oxytetracycline (E.2.6); F. Signal transduction inhibitors: - MAP / histidine kinase inhibitors: fluoroimid (F.1.1), iprodione (F.1.2), procymidone (F.1.3), vinclozoline (F.1.4) and fludioxonil (F.1.5); and - G protein inhibitors: quinoxifen (F.2.1); G. Inhibitors of lipid and membrane synthesis: - inhibitors of phospholipid biosynthesis: edifenphos (G.1.1), iprobenphos (G.1.2), pyrazophos (G.1.3) and isoprothiolan (G.1.4); - Lipid peroxidation: dichloran (G.2.1), quintozene (G.2.2), tecnazene (G.2.3), tolclofos-methyl (G.2.4), biphenyl (G.2.5), chloroneb (G.2.6), Petition 870250083202, dated 09 / 16 / 2025, pp. 250 / 317 99 / 159 etridiazole (G.2.7) and zinc thiazole (G.2.8); - Phospholipid biosynthesis and cell wall deposition: dimetomorph (G.3.1), flumorph (G.3.2), mandipropamid (G.3.3), pirimorph (G.3.4), bentiavalicarb (G.3.5), iprovalicarb (G.3.6) and valifenalate (G.3.7); - compounds that affect cell membrane permeability and fatty acids: propamocarb (G.4.1); and - inibidores da proteína de ligação de oxisterol: oxatiapiprolina (G.5.1), fluoxapiprolina (G.5.3), 4-[1-[2-[3-(difluorometil)-5-metilpirazol-1il]acetil]-4-piperidil]-N-tetralin-1 -ilpiridina-2-carboxamida (G.5.4), 4-[1 -[2-[3,5bis(difluorometil)pirazol-1-il]acetil]-4-piperidil]-N-tetralin-1-ilpiridina-2carboxamida (G.5.5), 4-[1 -[2-[3-(difluorometil)-5-(trifluorometil)pirazol-1 -il]acetil]4-piperidil]-N-tetralin-1 -ilpiridina-2-carboxamida (G.5.6), 4-[1 -[2-[5-ciclopropil-3(difluorometil)pirazol-1-il]acetil]-4-piperidil]- N -tetralin-1-ilpiridina-2-carboxamida (G.5.7), 4-[1 -[2-[5-metil-3-(trifluorometil)pirazol-1 -il]acetil]-4-piperidil]-N-tetralin1 -ilpiridina-2-carboxamida (G.5.8), 4-[1 -[2-[5-(difluorometil)-3-(trifluorometil)pirazol-1 -il]acetil]-4-piperidil]-N-tetralin-1 -ilpiridina-2-carboxamida (G.5.9), 4-[1-[2-[3,5-bis(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-ylpyridine2-carboxamide (G.5.10) and (4-[1-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1yl]acetyl]-4-piperidyl]-N-tetralin-1-ylpyridine-2-carboxamide (G.5.11); H. inhibitors with action at multiple sites: - Inorganic active substances: Bordeaux mixture (H.1.1), copper (H.1.2), copper acetate (H.1.3), copper hydroxide (H.1.4), copper oxychloride (H.1.5), basic copper sulfate (H.1.6) and sulfur (H.1.7); - thio and dithiocarbamates: ferbam (H.2.1), mancozeb (H.2.2), maneb (H.2.3), metam (H.2.4), metiram (H.2.5), propineb (H.2.6), thiram (H.2.7), zineb (H.2.8) and ziram (H.2.9); - organochlorine compounds: anilazine (H.3.1), chlorothalonil (H.3.2), Captafol (H.3.3), Captan (H.3.4), Folpet (H.3.5), Diclofluanid (H.3.6), Petition 870250083202, dated 09 / 16 / 2025, pp. 251 / 317 100 / 159 dichlorophen (H.3.7), hexachlorobenzene (H.3.8), pentachlorphenol (H.3.9) and its salts, phthalide (H.3.10) and tolylfluanid (H.3.11); and - guanidines and others: guanidine (H.4.1), dodine (H.4.2), dodine free base (H.4.3), guazatine (H.4.4), guazatine acetate (H.4.5), iminoctadine (H.4.6), iminoctadine triacetate (H.4.7), iminoctadine tris(albesylate) (H.4.8), dithianon (H.4.9) and 2,6-dimethyl-1H,5H-[1,4]dithyino[2,3-c:5,6c']dipyrrole-1,3,5,7(2H,6H)-tetraone (H.4.10); I. Inhibitors of cell wall synthesis: - Glucan synthesis inhibitors: validamycin (I.1.1) and polyoxin B (I.1.2); - melanin synthesis inhibitors: pyroquilone (I.2.1), tricyclazole (I.2.2), carpropamid (I.2.3), dicyclomet (I.2.4) and fenoxanil (I.2.5); J. inducers of plant defense: - acibenzolar S-methyl (J.1.1), probenazole (J.1.2), isotianil (J.1.3), thiadinyl (J.1.4) and prohexadione calcium (J.1.5); phosphonates: fosetyl (J.1.6), fosetyl-aluminum (J.1.7), phosphorous acid and its salts (J.1.8), calcium phosphonate (J.1.11), potassium phosphonate (J.1.12), potassium or sodium bicarbonate (J.1.9) and 4-cyclopropyl-N-(2,4-dimethoxyphenyl)thiadiazole-5-carboxamide (J.1.10); K. unknown mode of action: - bronopol (K.1.1), quinomethionate (K.1.2), cyflufenamid (K.1.3), cymoxanil (K.1.4), dazomet (K.1.5), debacarb (K.1.6), diclocimet (K.1.7), diclomesin (K.1.8), difenzoquat (K.1.9), difenzoquat methylsulfate (K.1.10), diphenylamine (K.1.11), fenitropan (K.1.12), fempyrazamine (K.1.13), flumetover (K.1.14), flumetilsulforim (K.1.60), flusulfamide (K.1.15), flutianil (K.1.16), harpin (K.1.17), metasulfocarb (K.1.18), nitrapyrin (K.1.19), nitrothal-isopropyl (K.1.20), tolprocarb (K.1.21), copper oxine (K.1.22), proquinazid (K.1.23), seboctilamine (K.1.61), tebufloquine (K.1.24), teclophthalam (K.1.25), triazoxide (K.1.26), N-(4-(4chloro-3-trifluoromethylphenoxy)-2,5-dimethylphenyl)- N -ethyl- N -methyl formamidine (K.1.27), Petition 870250083202, de 16 / 09 / 2025, pag. 252 / 317 101 / 159 N'-(4-(4-fluoro-3-trifluoromethylphenoxy)-2,5-dimethylphenyl)-N-ethyl-N-methyl formamidine (K.1.28), N-[4-[[3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazol-5-yl]oxy]-2,5-dimethylphenyl]- N ethyl- N -methylformamidine (K.1.29), N'-(5-bromo-6-indan-2-yloxy-2-methyl-3-pyridyl)- N ethyl- N -methylformamidine (K.1.30), N'-[5-bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2methyl-3-pyridyl]-N-ethyl-N -methylformamidine (K.1.31), N'-[5-bromo-6-(4isopropylcyclohexoxy)-2-methyl-3-pyridyl]-N ethyl-N -methylformamidine (K.1.32), N'-[5-bromo-2-methyl-6-(1-phenylethoxy)-3-pyridyl]-N-ethyl-N-methylformamidina (K.1.33), N'-(2-methyl-5-trifluoromethyl-4-(3-trimethylsilanylpropóxi)-phenyl)-N-ethyl-N -methyl formamidina (K.1.34), N'-(5-difluoromethyl-2-methyl-4-(3-trimethylsilanylpropóxi)-phenyl)- N -ethylN-methyl formamidine (K.1.35), 2-(4-chlorophenyl)-N-[4-(3,4-dimethoxyphenyl)-isoxazol5-yl]-2-prop-2-ynyloxyacetamide (K.1.36), 3-[5-(4-chlorophenyl)-2,3dimethylisoxazolidin-3-yl]-pyridine (pyrisoxazole) (K.1.37), 3-[5-(4-methylfenil)-2,3dimethylisoxazolidin-3-yl]-pyridine (K.1.38), 5-cloro-1-(4,6-dimethoxypyrimidin-2-yl)-2metil-1 H-benzoimidazole (K.1.39), (Z)-3-amino-2-cyano-3-fenilprop-2-enoato de etila (K.1.40), picarbutrazox (K.1.41) (K.1.44), quinofumelina (K.1.47), benzisothiazolinone (K.1.48), bromatolonil (K.1.49), 2-(6-benzyl-2-pyridyl)quinazoline (K.1.50), 2-[6-(3fluoro-4-methoxyphenyl)-5-methyl-2-pyridyl]quinazoline (K.1.51), diclobenthiazox (K.1.52), N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N -methylformamidine (K.1.53), aminopirifen (K.1.54), fluopimomide (K.1.55), N'-[5-bromo-2-methyl-6-(1-methyl2-propoxyethoxy)-3-pyridyl]-N-ethyl-N-methylformamidine (K.1.56), N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethylphenyl]- N -ethyl- N -methylformamidine (K.1.57), flufenoxadiazam (K.1.58), N-metil-4-[5-(trifluorometil)-1,2,4-oxadiazol-3-yl]benzenocarbotioamida (K.1.59), N -metóxi- N -[[4-[5-(trifluorometil)-1,2,4-oxadiazol-3yl]fenil]metil]ciclopropanocarboxamida (K.1.60; WO 2018 / 177894 e WO 2020 / 212513), N -((4-[5-(trifluorometil)-1,2,4-oxadiazol-3Petição 870250083202, de 16 / 09 / 2025, pág. 253 / 317. 102 / 159 il]fenil)metil)propanamide (K.1.62), 3,3,3-trifluoro-N -[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.63), 3,3,3 trifluoro- N -[[2-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.64), N -[2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4oxadiazol-3-yl]benzyl]butanamide (K.1.65), N-[[2,3-difluoro-4-[5-(trifluoromethyl)1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoropropanamide (K.1.66), 1 -methoxy-1 methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.67), 1,1diethyl-3-[[4-[5-[trifluoromethyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.68), N ,2-dimethoxy-N -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.69), N -ethyl-2-methyl- N -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.70), 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.71), 1 -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one (K. 1.72), yl]phenyl]methyl]piperidin-2-one (K. 1.73), yl]phenyl]methyl]morpholin-3-one (K.1.74), -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3· 4-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3· 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one (K.1.75), 2-[[4-[5-(trifluoromethyl)1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one (K.1.76), 5,5-dimethyl-2-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one (K.1.77), 3,3-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piperidin-2-one (K.1.78), 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]oxazinan-3-one (K.1.79), 1 -[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]azepan2-one (K.1.80), 4,4-dimethyl-1 -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one (K.1.81), 5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one (K. 1.82), 1 -[[4-[5-(trifluoromethyl)-1,2,4oxadiazol-3 yl]phenyl]methyl]pyrazole-4-carboxylate de ethyl (K.1.83), N -methyl-1-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.84), N, N-dimethyl-1 -[4-[5-(trifluorometil)-1,2,4-oxadiazol-3-yl]benzyl]-1H-1,2,4-triazol-3amina (K.1.85), N -metóxi-N -metil-1-[[4-[5-(trifluorometil)-1,2,4-oxadiazol-3-yl]benzyl]-1H-1,2,4-triazol-3amina (K.1.85), N -metóxi-N -metil-1-[[4-[5-(trifluorometil)-1,2,4-oxadiazol-3-yl]Petição 870250083202, de 16 / 09 / 2025, pág. 254 / 317 103 / 159 yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.86), propil-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-pyrazole-4-carboxamide (K.1.87), N -methoxy-1-[[4-[5(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.88), N allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.89), 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.90), 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.91), N-allyl-N -[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide (K.1.92), N -[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]cyclopropanecarboxamide (K.1.93), 1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.94), N'-[2-chloro-4-(2-fluorophenoxy)-5methylphenyl]-N-ethyl-N-methylformamidine (K.1.95), N'-[2-chloro-4-[(4-methoxyphenyl)methyl]5-methylphenyl]-N-ethyl-N-methylformamidine (K.1.96), N'-[2-chloro-4-[(4cyanophenyl)methyl]-5-methylphenyl]-N-ethyl-N -methylformamidine (K.1.97), N'-[2,5-dimethyl4-(o-tolylmethyl)phenyl]-N-ethyl-N-methylformamidine (K.1.98), 6-chloro-3-(3-cyclopropyl-2fluorophenoxy)-N -[2-(2,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4carboxamide (K.1.99), 3-(3-bromo-2-fluorophenoxy)-6-chloro-N-[2-(2-chloro-4-methylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4-carboxamide (K.1.100), 6-chloro-N-[2-(2-chloro-4-methylphenyl)-2,2-difluoroethyl]-3-(3-cyclopropyl-2-fluorophenoxy)-5-methylpyridazine-4-carboxamide (K.1.101), 6-chloro-3-(3-cyclopropyl-2-fluorophenoxy)N-[2-(3,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4-carboxamide (K.1.102), 6-chloro-3-(3-chloro-2-fluorophenoxy)-N -[2-(2,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazine-4-carboxamide (K.1.103) and N-[2-(2-bromo-4-methylphenyl)-2,2-difluoroethyl]-6-chloro-3-(3-cyclopropyl-2-fluorophenoxy)-5-methylpyridazine-4-carboxamide (K.1.104); L. biopesticides: L1. Microbial pesticides with fungicidal, bactericidal, virucidal and / or plant defense-activating activity: Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus altitudinis, B. Petition 870250083202, dated 09 / 16 / 2025, pp. 255 / 317 104 / 159 amyloliquefaciens, B. amyloliquefaciens ssp. plantarum (also called B. velezensis), B. megaterium, B. mojavensis, B. mycoides, B. pumilus, B. simplex, B. solisalsi, B. subtilis, B. subtilis var. amyloliquefaciens, B. velezensis, Candida oleophila, C. saitoana, Clavibacter michiganensis (bacteriophages), Coniothyrium minitans, Cryphonectria parasitica, Cryptococcus albidus, Dilophosphora alopecuri, Fusarium oxysporum, Clonostachys rosea f. catenulate (also called Gliocladium catenulatum), Gliocladium roseum, Lysobacter antibioticus, L. enzymogenes, Metschnikowia fructicola, Microdochium dimerum, Microsphaeropsis ochracea, Muscodor albus, Paenibacillus alvei, Paenibacillus epiphyticus, P. polymyxa, Pantoea vagans, Penicillium bilaiae, Phlebiopsis gigantea, Pseudomonas sp., Pseudomonas chloraphis, Pseudozyma flocculosa, Pichia anomala, Pythium oligandrum, Sphaerodes mycoparasitica, Streptomyces griseoviridis, S. lydicus, S.violaceusniger, Talaromyces flavus, Trichoderma asperelloides, T. asperellum, T. atroviride, T. fertile, T. gamsii, T. harmatum, T. harzianum, T. polysporum, T. stromaticum, T. virens, T. viride, Typhula phacorrhiza, Ulocladium oudemansii, Verticillium dahlia and yellow mosaic virus from zucchini (avirulent strain); L2. Biochemical pesticides with fungicidal, bactericidal, virucidal and / or plant defense-activating activity: harpin protein and Reynoutria sachalinensis extract; L3. microbial pesticides with insecticidal, acaricidal, mollusquicidal and / or nematicidal activity: Agrobacterium radiobacter, Bacillus cereus, B. firmus, B. thuringiensis, B. thuringiensis ssp. aizawai, B.t. ssp. israelensis, B. t. ssp. galleriae, B. t. ssp. kurstaki, B.t. ssp. tenebrionis, Beauveria bassiana, B. brongniartii, Burkholderia spp., Chromobacterium subtsugae, Cydia pomonella granulovirus (CpGV), Cryptophlebia leucotreta granulovirus (CrleGV), Flavobacterium spp., Helicoverpa armigera nucleopolyhedrovirus (HearNPV), Helicoverpa zea nucleopolyhedrovirus (HzNPV), nucleopolyhedrovirus of Petition 870250083202, dated 09 / 16 / 2025, pp. 256 / 317 105 / 159 capsid isolated from Helicoverpa zea (HzSNPV), Heterorhabditis bacteriophora, Isaria fumosorosea, Lecanicillium longisporum, L. muscarium, Metarhizium anisopliae, M. anisopliae var. anisopliae, M. anisopliae var. acridum, Nomuraea rileyi, Paecilomyces fumosoroseus, P. lilacinus, Paenibacillus popilliae, Pasteuria ssp., P. nishizawae, P. penetrans, P. ramosa, P. thornea, P. usgae, Pseudomonas fluorescens, Spodoptera littoralis nucleopolyhedrovirus (SpliNPV), Steinernema carpocapsae, S. feltiae, S. kraussei, Streptomyces galbus and S. microflavus; L4. biochemical pesticides with insecticidal, acaricidal, mollusquicidal, pheromone and / or nematicidal activity: L-carvone, citral, (E, Z )7,9-dodecadien-1-yl acetate, ethyl formate, (E, Z )-2,4-ethyl decadienoate (pear ester), (Z,Z,E)-7,11,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, cis-jasmone, 2-methyl-1-butanol, methyl eugenol, methyl jasmonate, (E,Z)-2,13-octadecadien-1-ol, (E,Z)2,13-octadecadien-1-ol acetate, (E,Z) -3,13-octadecadien-1-ol, (R )-1 -octen-3-ol, pentatermanone, (E, Z, Z)-3,8,11-tetradecatrienyl acetate, (Z, E)9,12-tetradecadien-1-yl acetate, (Z)-7-tetradecen-2-one, (Z)-9-tetradecen-1-yl acetate, (Z)-11-tetradecenal, (Z)-11-tetradecen-1-ol, Chenopodium ambrosiodes extract, neem oil and quillaja extract; and L5. Microbial pesticides with plant stress-reducing, plant growth-regulating, growth-promoting and / or plant yield-enhancing activity: Azospirillum amazonense, A. brasilense, A. lipoferum, A. irakense, A. halopraeferens, Bradyrhizobium spp., B. elkanii, B. japonicum, B. liaoningense, B. lupini, Delftia acidovorans, Glomus intraradices, Mesorhizobium spp., Rhizobium leguminosarum bv. phaseolii, R. l. bv. trifolii, R. l. bv. viciae, R. tropici and Sinorhizobium meliloti; Insecticides of classes O.1 to O.29: O.1. Acetylcholine esterase (AChE) inhibitors: aldicarb, Petition 870250083202, dated 09 / 16 / 2025, pp. 257 / 317 106 / 159 alanicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furatiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, tiodicarb, tiofanox, trimetacarb, diazinon, dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, etoprophos, fanfur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imiciaphos, isofenphos, O-(methoxyaminothiophosphoryl) isopropyl salicylate, isoxation, malathion, mecarbam, methamidophos, metidathion, mevinphos, monocrotophos, naled, omethoate, oxidemeton-methyl, parathion, parathion-methyl, phentoate, phorate, phosalone, phosmet, phosfamidon, phoxim, pirimiphos-methyl, profenophos, propetanphos, prothiophos, pyraclophos, pyridafenthion, quinalphos,sulfotep, tebupirinphos, temephos, terbufós, tetrachlorvinphos, thiometon, triazophos, trichlorfon and vamidothion;, O.2. GABA-blocked chloride channel antagonists: endosulfan, chlordane, etiprol, fipronil, flufiprol, pirafluprol and pyriprol; O.3. Sodium channel modulators: acrinathrin, allethrin, d-cistrans allethrin, d-trans allethrin, bifenthrin, kappa-bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cy-halothrin, gamma-cy-halothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyfenothrin, deltamethrin, empentrin, esfenvalerate, etofemprox, fempropathrin, fenvalerate, flucitrinate, flumethrin, tau-fluvalinate, halfemprox, heptafluthrin, imiprothrin, meperfluthrin, metofluthrin, monfluorothrin, epsilon-monfluorothrin, permethrin, phenothrin, pralethrin, profluthrin, pyrethrin (pyrethrum), resmethrin, silafluofen, tefluthrin, capatefluthrin, tetramethylfluthrin, tetramethrin, tralomethrin, transfluthrin, DDT and methoxychlor; O.4. Nicotinic acetylcholine receptor (nAChR) antagonists: Petition 870250083202, dated 09 / 16 / 2025, pp. 258 / 317 107 / 159 acetamiprid, clothianidin, cycloxaprid, dinotefuran, imidacloprid, nitempram, thiacloprid, thiamethoxam, 4,5-dihydro-N -nitro-1 -(2-oxiranylmethyl)-1 H -imidazol-2amine, (2 E )-1-[(6-chloropyridin-3-yl)methyl]- N-nitro-2-pentylidenehydrazinocarboximidamide; 1-[(6-chloropyridin-3-yl)methyl]-7-methyl-8-nitro-5-propoxy1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridine; nicotine; sulfoxaflor, flupyradifurone, triflumezopyrim, fenmezodithiaz and flupirimin; O.5. Allosteric activators of the nicotinic acetylcholine receptor: spinosad and spinetoram; O.6. Chloride channel activators: abamectin, emamectin benzoate, ivermectin, lepimectin and milbemectin; O.7. juvenile hormone mimics: hydroprene, cynoprene, methoprene, fenoxycarb and pyriproxyfen; O.8. Various non-specific inhibitors (multilocal): methyl bromide and other alkyl halides; chloropicrin, sulfuryl fluoride, borax and tartar emetic; O.9. TRPV channel modulators of the chordotonal organ: afidopyropen, pimetrozine and pirifluquinazone; O.10. Inhibitors of mite growth: clofentezine, hexithiazox, diflovidazine and ethoxazole; O.11. Microbial disruptors of insect midgut membranes: Bacillus thuringiensis, B. sphaericus and the insecticidal proteins they produce: Bacillus thuringiensis subsp. israelensis, B. sphaericus, B. thuringiensis subsp. aizawai, B. thuringiensis subsp. kurstaki, B. thuringiensis subsp. tenebrionis and the Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb and Cry34 / 35Ab1; O.12. Mitochondrial ATP synthase inhibitors: diafenthiuron; azocyclotine, cy-hexatine, fenbutatine oxide, propargite and tetradifon; O.13. Uncouplers of oxidative phosphorylation through Petition 870250083202, dated 09 / 16 / 2025, pp. 259 / 317 108 / 159 disruption of the proton gradient: chlorfenapyr, DNOC and sulfluramid; O.14. Nicotinic acetylcholine receptor (nAChR) channel blockers: bensultap, cartap hydrochloride, thiocyclam and thiosultap sodium; O.15. Inhibitors of type O chitin biosynthesis: bistrifluron, chlorfluazuron, diflubenzuron, flucicloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron; O.16. Inhibitors of type 1 chitin biosynthesis: ibuprofen; O.17. molt disruptors: cyromazine; O.18. Ecdyson receptor agonists: methoxyfenozide, tebufenozide, halofenozide, fufenozide and chromafenozide; O.19. Octopamine receptor agonists: amitraz; O.20. Inhibitors of mitochondrial complex III electron transport: hydramethylnon, acequinocil, fluacripyrim, and bifenazate; O.21. Inhibitors of mitochondrial complex I electron transport: phenazaquine, fenpyroximate, pirimidifen, pyridaben, tebufenpyrad, tolfempyrad, and rotenone; O.22. Voltage-dependent sodium channel blockers: indoxacarb, metaflumizone, 2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]N-[4-(difluoromethoxy)phenyl]-hydrazinocarboxamide, N-(3-chloro-2-methylphenyl)-2-[(4-chlorophenyl)-[4-[methyl(methylsulfonyl)amino]phenyl]methylene]-hydrazinocarboxamide, N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3(fluoromethoxy)-1H-pyrazol-5-carboxamide and 2-[2-(4-cyanophenyl)-1-[3(trifluoromethyl)phenyl]ethylidene]-N- -[4-(difluoromethoxy)phenyl]-hydrazinecarboxamide; O.23. Acetyl CoA carboxylase inhibitors: spirodiclofen, spiromesifen, spirotetramat, spiropidion, spirobudifen, 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one and spirodoxamat; O.24. electron transport inhibitors of the complex Petition 870250083202, dated 09 / 16 / 2025, pp. 260 / 317 109 / 159 mitochondrial IV: aluminum phosphide, calcium phosphide, phosphine, zinc phosphide and cyanide; O.25. Inhibitors of mitochondrial complex II electron transport: cyenopyrafamine, cyflumetofen, cyethyrapefamine and piflubamide; O.28. ryanodine receptor modulators: chlorantraniliprol, ciantraniliprol, cyclaniliprol, flubendiamida, fluclodiniliprol, (R )-3-chloro-N1-{2-methyl4-[1,2,2,2-tetrafluoro-1 -(trifluoromethyl)ethyl]phenyl}-N2-(1-methyl-2methylsulfonylethyl)phthalamida, (S )-3-chloro-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1 (trifluoromethyl)ethyl]phenyl}-N2-(1-methyl-2-methylsulfonethyl)phthalamida, 2-[3,5-dibromo-2({[3-bromo-1 -(3-chloropyridin-2-yl)-1 H-pyrazol-5-yl]carbonyl}amino)benzoyl]-1,2-dimethyl-hydrazinocarboxylate de methyl, N -[4,6-dichloro-2-[(diethyl-lambda-4-sulfanilideno)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazol-3-carboxamide, N-[4-chloro-2-[(diethyl-lambda-4-sulfanilideno)carbamoyl]-6methylphenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazol-3-carboxamide, N-[2-(5amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1 -(3-chloro-2-pyridinyl)-1 H pyrazol-5-carboxamida, 3-chloro-1 -(3-chloro-2-pyridinyl)-N-[2,4-dichloro-6-[[(1-cyano1-methylethyl)amino]carbonyl]phenyl]-1 H-pyrazol-5-carboxamide, tetrachlorantraniliprole, tetraniliprole, thiorantraniliprole, N -[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]6-methylphenyl]-1 -(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazol-5-carboxamide, cyhalodiamide and N -[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1(3-chloro-2-pyridinyl)-1H-pyrazol-5-carboxamide;, O.29. Modulators of the chordotonal organ: flonicamide; O.30. Allosteric modulators of the GABA-gated chloride channel: broflanilide, fluxamethamide, and isocycloseram; O.33. Calcium-activated potassium channel modulators: acinonapyr; O.34. Inhibitors of mitochondrial complex III electron transport at the Qi site: flomethoquine; Petition 870250083202, dated 09 / 16 / 2025, pp. 261 / 317 110 / 159 O.UN. insecticidal compounds with unknown or uncertain mode of action: afoxolaner, azadirachtin, amidoflumet, benzoximate, bromopropylate, quinomethionate, cryolite, ciproflanilide, dichloromezotiaz, dicofol, dimpropiridaz, flufenerim, flometoquin, fluensulfone, flu-hexafon, fluopiram, fluralaner, metaldehyde, methoxadiazone, piperonyl butoxide, pyridalyl, tioxazafen, trifluenfuronate, umifoxolaner, 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa9-azadispiro[4.2.4.2]-tetradec-11-en-10-one, 3-(4'-fluoro-2,4-dimethylbiphenyl-3-yl)4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one, 4-cyano-N -[2-cyano-5-[[[2,6dibromo-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]phenyl]-2-methylbenzamide, 4-cyano-3-[(4-cyano-2-methylbenzoyl)amino]N -[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]2-fluorobenzamide, N -[5-[[[2-chloro-6-cyano-4-[1,2,2,3,3,3-hexafluoro-1 (trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyanophenyl]-4-cyano-2methylbenzamide,N -[5-[[[2-bromo-6-chloro-4-[2,2,2-trifluoro-1 -hydroxy-1 (trifluorometil)ethyl]phenyl]amino]carbonyl]-2-cyanophenyl]-4-cyano-2-methylbenzamida, N -[5-[[[2-bromo-6-chloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluorometil)propyl]phenyl]amino]carbonyl]-2-cyanophenyl]-4-cyano-2-methylbenzamida, 4-cyano-N -[2cyano-5-[[[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluorometil)propyl]phenyl]amino]carbonyl]phenyl]-2-methylbenzamida, 1-[2-fluoro-4-methyl5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl]-3-(trifluoromethyl)-1H-1,2,4-triazol-5-amine, N -[5-[[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1 -(trifluoromethyl)ethyl]phenyl]amino]carbonyl]-2-cyanophenyl]-4-cyano-2-methylbenzamida, 4-cyanoN -[2-cyano-5-[[[2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]phenyl]-2-methylbenzamida, active ingredients in Bacillus firmus (Votivo, I1582), fluazaindolizine, 5-[3-[2,6-dichloro-4-(3,3-dichloroalyloxy)phenoxy]propoxy]1H-pyrazol, N -[5-[[2-bromo-6-chloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]carbamoyl]-2-cyanophenyl]-4-cyano-2-methylbenzamide, 4-cyano-N-[2cyano-5-[[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)] Petition 870250083202, dated 09 / 16 / 2025, page 262 / 317, 111 / 159 propyl]phenyl]carbamoyl]phenyl]-2-methylbenzamide, 4-cyano-N -[2-cyano-5-[[2,6-dichloro4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]carbamoyl]phenyl]-2-methylbenzamide, N -[5-[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]carbamoyl]2-cyanophenyl]-4-cyano-2-methylbenzamide, 2-(1,3-dioxan-2-yl)-6-[2-(3-pyridinyl)-5thiazolyl]-pyridine, 2-[6-[2-(5-fluoro-3-pyridinyl)-5-thiazolyl]-2-pyridinyl]-pyrimidine, 2-[6[2-(3-pyridinyl)-5-thiazolyl]-2-pyridinyl]-pyrimidine, N -methylsulfonyl-6-[2-(3-pyridyl)thiazol5-yl]pyridine-2-carboxamide, N -methylsulfonyl-6-[2-(3-pyridyl)thiazol-5-yl]pyridine-2-carboxamide, 1 -[(6-chloro-3-pyridinyl)methyl]-1,2,3,5,6,7-hexa-hydro-5-methoxy-7methyl-8-nitroimidazo[1,2-a]pyridine, 1 -[(6-chloropyridin-3-yl)methyl]-7-methyl-8-nitro1,2,3,5,6,7-hexa-hydroimidazo[1,2-a]pyridin-5-ol, N -(3-chloro-2-methylphenyl)-2-[(4chlorophenyl)[4-[methyl(methylsulfonyl)amino]phenyl]methylene]-hydrazinocarboxamide, 1[(6-chloro-3-pyridinyl)methyl]-1,2,3,5,6,7-hexa-hidro-5-metóxi-7-metil-8nitroimidazo[1,2-a]piridina, 2-(3-piridinil)-N -(2-pirimidinilmetil)-2H-indazol-5carboxamida, ticlopirazoflor, sarolaner, lotilaner, N -[4-cloro-3-[[(fenilmetil)amino]carbonil]fenil]-1 -metil-3-(1,1,2,2,2-pentafluoroetil)-4-(trifluorometil)-1 H-pirazol5-carboxamida, N -[4-cloro-3-[[(fenilmetil)amino]carbonil]fenil]-1-metil3-(1,1,2,2,2-pentafluoroetil)-4-(trifluorometil)-1 H-pirazol-5-carboxamida, 2-(3etilsulfonil-2-piridil)-3-metil-6-(trifluorometil)imidazo[4,5-b]piridina, 2-[3etilsulfonil-5-(trifluorometil)-2-piridil]-3-metil-6-(trifluorometil)imidazo[4,5b]piridina, N -[4-cloro-3-(ciclopropilcarbamoil)fenil]-2-metil-5-(1,1,2,2,2pentafluoroetil)-4-(trifluorometil)pirazol-3-carboxamida, N -[4-cloro-3-[(1cianociclopropil)carbamoil]fenil]-2-metil-5-(1,1,2,2,2-pentafluoroetil)-4-(trifluorometil)pirazol-3-carboxamida, benzopirimoxan, tigolaner, oxazossulfila, [(2 S ,3 R ,4 R ,5 S ,6 S )-3,5-dimethoxy-6-methyl-4-propoxytetra-hydropyran-2-yl]-N -[4-[1[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate, [(2 S ,3 R ,4 R ,5 S, 6 )3,4,5-trimethoxy-6-methyltetra-hydropyran-2-yl]- N -[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4triazol-3-yl]phenyl]carbamate, [(2 S ,3 R ,4 R ,5 S ,6 S )-3,5-dimethoxy-6-methyl-4propoxytetra-hydropyran-2-yl]- N -[4-[1 -[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4Petition 87025008326 / 9, pá2 / 12 263 / 317, 112 / 159 triazol-3-yl]phenyl]carbamate, [(2 S ,3 R ,4 R ,5 S ,6 S )-3,4,5-trimethoxy-6-methyltetrahidropyran-2-yl]- N -[4-[1 -[4-(1,1,2,2,2-pentafluoroethóxi)phenyl]-1,2,4-triazol-3yl]phenyl]carbamate, (2 Z) -3-(2-isopropylphenyl)-2-[( E )-[4-[1-[4-(trifluorometóxi)phenyl]1,2,4-triazol-3-yl]phenyl]methyleno-hidrazono]thiazolidin-4-ona, (2 Z) -3-(2isopropylphenyl)-2-[( E )-[4-[1 -[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3yl]phenyl]methyleno-hydrazono]thiazolidin-4-one, (2 Z )-3-(2-isopropylphenyl)-2-[( E )-[4-[1[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]methyleno-hydrazono]thiazolidin-4-one, 2-(6-chloro-3-ethylsulfonylimidazo[1,2-a]pyridin-2-yl)-3methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(6-bromo3-ethylsulfonylimidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5b]pyridine, 2-(3-ethylsulfonyl-6-iodoimidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(7-chloro-3-ethylsulfonylimidazo[1,2-a]pyridin-2-yl)-3methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(3-ethylsulfonyl-7-iodoimidazo[1,2a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 3-ethylsulfonyl-6-iodo2-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imidazo[1,2-a]pyridine-8carbonitrila, 2-[3-ethylsulfonyl-8-fluoro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6(trifluoromethylsulfinyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-c]pyridine, 2-(6-bromo-3-ethylsulfonylimidazo[1,2-a]pyridin-2-yl)-6-(trifluoromethyl)pyrazolo[4,3c]pyridine, N -[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide, 2-[2-fluoro-4methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-ona, flupentiofenox,N-[3-chloro-1-(3-pyridyl)pyrazol-4-yl]-2-methylsulfonylpropanamida, cyclobutrifluram, N-[4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl]-2-methyl-4methylsulfonyl-5-(1,1,2,2,2-pentafluoroethyl)pyrazol-3-carboxamida, ciproflanilida, nicofluprol, 1,4-dimetil-2-[2-(piridin-3-yl)-2 H -indazol-5-yl]-1,2,4-triazolidina-3,5Petição 870250083202, de 16 / 09 / 2025, pág. 264 / 317, 113 / 159 diona, 2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfanyl)phenyl]imino-3-(2,2,2trifluoroethyl)thiazolidin-4-ona, indazapiroxamet, N -[4-chloro-2-(3-pyridyl)thiazol-5-yl]-N ethyl-3-methylsulfonylpropanamida, N -cyclopropyl-5-[(5 S )-5-(3,5-dichloro-4-fluorophenyl)5-(trifluoromethyl)-4 H -isoxazol-3-yl]isoquinoline-8-carboxamida, 5-[(5 S )-5-(3,5dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 H-isoxazol-3-yl]- N -(pyrimidin-2-ylmethyl)isoquinoline-8-carboxamida, N -[1-(2,6-difluorophenyl)pyrazol-3-yl]2-(trifluoromethyl)benzamida, 5-((1 R ,3 R )-3-(3,5-bis(trifluoromethyl)phenyl)-2,2dichlorocyclopropane-1-carboxamido)-2-chloro-N -(3-(2,2-difluoroacetamido)-2,4difluorophenyl)benzamida, 1 -[6-(2,2-difluoro-7-methyl-[1,3]dioxolo[4,5f]benzimidazol-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropanecarbonitrila and 6-(5cyclopropyl-3-ethylsulfonyl-2-pyridyl)-2,2-difluoro-7-methyl-[1,3]dioxol[4,5f]benzimidazole.

[00264] The active substances indicated as component 2, their preparation and their activity, for example, against harmful fungi, are known (cf.: http: / / www.alanwood.net / pesticides / ) and these substances are commercially available. The compounds described by the IUPAC nomenclature, their preparation and their pesticidal activity are also known (cf. Can. J. Plant Sci. 48 (6), 587-94, 1968, EP-A 141.317, EP-A 152.031, EP-A 226.917, EP-A 243.970, EP-A 256.503, EP-A 428.941, EP-A 532.022, EP-A 1.028.125, EP-A 1,035,122, EP-A 1,201,648, EP-A 1,122,244, JP 2002 / 316902, DE 19650197, DE 10021412, DE 102005009458, US 3,296,272, US 3,325,503, WO 98 / 46608, WO 99 / 14187, WO 99 / 24413, WO 99 / 27783, WO 00 / 29404, WO 00 / 46148, WO 00 / 65913, WO 01 / 54501, WO 01 / 56358, WO 02 / 22583, WO 02 / 40431, WO 03 / 10149, WO 03 / 11853, WO 03 / 14103, WO 03 / 16286, WO 03 / 53145, WO 03 / 61388, WO 03 / 66609, WO 03 / 74491, WO 04 / 49804, WO 04 / 83193, WO 05 / 120234, WO 05 / 123689, WO 05 / 123690, WO 05 / 63721, WO 05 / 87772, WO 05 / 87773, WO 06 / 15866, WO 06 / 87325, WO 06 / 87343,WO 07 / 82098, WO 07 / 90624, WO 10 / 139271, WO 11 / 028657, WO 12 / 168188, WO Petição 870250083202, de 16 / 09 / 2025, pág. 265 / 317 114 / 159 07 / 006670, WO 11 / 77514, WO 13 / 047749, WO 10 / 069882, WO 13 / 047441, WO 03 / 16303, WO 09 / 90181, WO 13 / 007767, WO 13 / 010862, WO 13 / 127704, WO 13 / 024009, WO 13 / 24010, WO 13 / 047441, WO 13 / 162072, WO 13 / 092224, WO 11 / 135833, CN 1907024, CN 1456054, CN 103387541, CN 1309897, WO 12 / 84812, CN 1907024, WO 09094442, WO 14 / 60177, WO 13 / 116251, WO 08 / 013622, WO 15 / 65922, WO 94 / 01546, EP 2865265, WO 07 / 129454, WO 12 / 165511, WO 11 / 081174, WO 13 / 47441, WO 16 / 156241 and WO 16 / 162265). Some compounds are identified by their CAS Registry Number, which is separated by hyphens into three parts, where the first consists of two to seven digits, the second consists of two digits, and the third consists of a single digit.

[00265] According to the present invention, the solid material (dry matter) of biopesticides (with the exception of oils such as neem oil) is considered the active component (for example, to be obtained after drying or evaporation of the extraction medium or suspension in the case of liquid formulations of microbial pesticides). The weight ratios and percentages used for a biological extract, such as quillaja extract, are based on the total weight of the dry content (solid material) of the corresponding extract(s).

[00266] The total weight ratios of compositions comprising at least one microbial pesticide in the form of viable microbial cells, including dormant forms, can be determined using the CFU quantity of the corresponding microorganism to calculate the total weight of the corresponding active component with the following equation, where 1 x 1010 CFU equals one gram of the total weight of the corresponding active component. The colony forming unit is the measure of viable microbial cells. Furthermore, "CFU" can also be understood as the quantity of individual nematodes (juveniles) in the case of nematode biopesticides, such as Steinernema feltiae. Petition 870250083202, dated 09 / 16 / 2025, pp. 266 / 317 115 / 159

[00267] In binary mixtures, the weight ratio between component 1 and component 2 normally depends on the properties of the components used and is generally in the range of 1:10,000 to 10,000:1, normally 1:100 to 100:1, regularly 1:50 to 50:1, preferably 1:20 to 20:1, more preferably 1:10 to 10:1, even more preferably 1:4 to 4:1 and, particularly, 1:2 to 2:1. According to further embodiments, the weight ratio between component 1 and component 2 is generally in the range of 1000:1 to 1:1, normally 100:1 to 1:1, regularly 50:1 to 1:1, preferably 20:1 to 1:1, more preferably 10:1 to 1:1, even more preferably 4:1 to 1:1 and, particularly, 2:1 to 1:1. According to further embodiments, the weight ratio between component 1 and component 2 is generally in the range of 20,000:1 to 1:10, frequently 10,000:1 to 1:1, regularly 5,000:1 to 5:1, preferably 5,000:1 to 10:1, more preferably 2.000:1 to 30:1, preferably even higher 2,000:1 to 100:1 and, particularly, 1,000:1 to 100:1. According to further embodiments, the weight ratio between component 1 and component 2 is generally in the range of 1:1 to 1:1000, frequently 1:1 to 1:100, regularly 1:1 to 1:50, preferably 1:1 to 1:20, most preferably 1:1 to 1:10, even more preferably 1:1 to 1:4 and, particularly, 1:1 to 1:2. According to further realizations, the weight ratio between component 1 and component 2 is generally in the range of 10:1 to 1:20,000, frequently 1:1 to 1:10,000, regularly 1:5 to 1:5,000, preferably 1:10 to 1:5,000, more preferably 1:30 to 1:2,000, even more preferably 1:100 to 1:2,000 and, particularly, 1:100 to 1:1,000.

[00268] In ternary mixtures, that is, compositions comprising component 1, component 2 and a compound III (component 3), the weight ratio between component 1 and component 2 depends on the properties of the active substances used. It is normally found in Petition 870250083202, dated 09 / 16 / 2025, pp. 267 / 317 116 / 159 range of 1:100 to 100:1, regularly 1:50 to 50:1, preferably 1:20 to 20:1, most preferably 1:10 to 10:1, particularly 1:4 to 4:1; and the weight ratio between component 1 and component 3 is normally found in the range of 1:100 to 100:1, regularly 1:50 to 50:1, preferably 1:20 to 20:1, most preferably 1:10 to 10:1 and, particularly, 1:4 to 4:1. Any additional active component is added, if desired, in a ratio of 20:1 to 1:20 with component 1. These ratios are also appropriate for mixtures applied by seed treatment.

[00269] When mixtures comprising microbial pesticides are used in agricultural protection, application rates vary in the range of 1 x 10⁶ to 5 x 10¹⁶ (or more) CFU / ha, preferably 1 x 10⁸ to 1 x 10¹³ CFU / ha, more preferably 1 x 10⁹ to 5 x 10¹⁵ CFU / ha and, particularly, 1 x 10¹² to 5 x 10¹⁴ CFU / ha. In the case of nematodes as microbial pesticides (e.g., Steinernema feltiae), application rates are regularly in the range of 1 x 10⁵ to 1 x 10¹² (or more), preferably 1 x 10⁸ to 1 x 10¹¹ and, more preferably, 5 x 10⁸ to 1 x 10¹⁰ individuals (e.g., in the form of eggs, juveniles or any other life stage, preferably in an infertile juvenile stage) per hectare.

[00270] When mixtures comprising microbial pesticides are used in seed treatment, application rates will generally be in the range of 1 x 10⁶ to 1 x 10¹² (or more) CFU / seed, preferably 1 x 10⁶ to 1 x 10⁹ CFU / seed. In addition, application rates for seed treatment are generally in the range of 1 x 10⁷ to 1 x 10¹⁴ (or more) CFU per 100 kg of seeds, preferably 1 x 10⁹ to 1 x 10¹² CFU per 100 kg of seeds.

[00271] Preference is given to mixtures comprising, as component 2, at least one active substance selected from inhibitors of complex III at the Qo site of group (A), most preferably Petition 870250083202, dated 09 / 16 / 2025, pp. 268 / 317 117 / 159 selected from compounds (A.1.1), (A.1.4), (A.1.8), (A.1.9), (A.1.10), (A.1.12), (A.1.13), (A.1.14), (A.1.17), (A.1.21), (A.1.25), (A.1.34) and (A.1.35); particularly selected from (A. 1.1), (A. 1.4), (A. 1.8), (A. 1.9), (A. 1.13), (A. 1.14), (A. 1.17), (A. 1.25), (A. 1.34) and (A. 1.35).

[00272] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from inhibitors of complex III at the Qi site of group (A), most preferably selected from compounds (A.2.1), (A.2.3), (A.2.4) and (A.2.6); particularly selected from (A.2.3), (A.2.4) and (A.2.6).

[00273] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from complex II inhibitors of group (A), most preferably selected from compounds (A.3.2), (A.3.3), (A.3.4), (A.3.7), (A.3.9), (A.3.11), (A.3.12), (A.3.15), (A.3.16), (A.3.17), (A.3.18), (A.3.19), (A.3.20), (A.3.21), (A.3.22), (A.3.23), (A.3.24), (A.3.28), (A.3.31), (A.3.32), (A.3.33), (A.3.34), (A.3.35), (A.3.36), (A.3.37), (A.3.38) and (A.3.39); particularly selected from (A.3.2), (A.3.3), (A.3.4), (A.3.7), (A.3.9), (A.3.12), (A.3.15), (A.3.17), (A.3.19), (A.3.22), (A.3.23), (A.3.24), (A.3.31), (A.3.32), (A.3.33), (A.3.34), (A.3.35), (A.3.36), (A.3.37), (A.3.38) and (A.3.39).

[00274] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from other respiration inhibitors of group (A), more preferably selected from compounds (A.4.5) and (A.4.11); particularly (A.4.11).

[00275] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from C14 demethylase inhibitors of group (B), most preferably selected from compounds (B.1.4), (B.1.5), (B.1.8), (B.1.10), Petition 870250083202, dated 09 / 16 / 2025, pp. 269 / 317 118 / 159 (B.1.11), (B.1.12), (B.1.13), (B.1.17), (B.1.18), (B.1.21), (B.1.22), (B.1.23), (B.1.25), (B.1.26), (B.1.29), (B.1.34), (B.1.37), (B.1.38), (B.1.43), (B.1.46), (B.1.53), (B.1.54) and (B.1.55); particularly selected from (B.1.5), (B.1.8), (B.1.10), (B.1.17), (B.1.22), (B.1.23), (B.1.25), (B.1.33), (B.1.34), (B.1.37), (B.1.38), (B.1.43) and (B.1.46).

[00276] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from delta-14-reductase inhibitors of group (B), more preferably selected from compounds (B.2.4), (B.2.5), (B.2.6) and (B.2.8); particularly (B.2.4).

[00277] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from phenylamides and acyl amino acid fungicides of group (C), more preferably selected from compounds (C. 1.1), (C. 1.2), (C. 1.4) and (C. 1.5); particularly selected from (C. 1.1) and (C. 1.4).

[00278] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from other nucleic acid synthesis inhibitors of group (C), most preferably selected from compounds (C.2.6), (C.2.7) and (C.2.8).

[00279] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (D), most preferably selected from compounds (D. 1.1), (D. 1.2), (D. 1.5), (D. 2.4) and (D. 2.6); particularly selected from (D. 1.2), (D. 1.5) and (D. 2.6).

[00280] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (E), most preferably selected from Petition 870250083202, dated 09 / 16 / 2025, pp. 270 / 317 119 / 159 compounds (E. 1.1), (E. 1.3), (E. 2.2) and (E. 2.3); particularly (E. 1.3).

[00281] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (F), most preferably selected from compounds (F. 1.2), (F. 1.4) and (F. 1.5).

[00282] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (G), most preferably selected from compounds (G. 3.1), (G. 3.3), (G. 3.6), (G. 5.1), (G. 5.3), (G. 5.4), (G. 5.5), (G. 5.6), (G. 5.7), (G. 5.8), (G. 5.9), (G. 5.10) and (G. 5.11); particularly selected from (G. 3.1), (G. 5.1) and (G. 5.3).

[00283] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (H), most preferably selected from compounds (H. 2.2), (H. 2.3), (H. 2.5), (H. 2.7), (H. 2.8), (H. 3.2), (H. 3.4), (H. 3.5), (H. 4.9) and (H. 4.10); particularly selected from (H. 2.2), (H. 2.5), (H. 3.2), (H. 4.9) and (H. 4.10).

[00284] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (I), most preferably selected from compounds (I.2.2) and (I.2.5).

[00285] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (J), most preferably selected from compounds (J.1.2), (J.1.5), (J.1.8), (J.1.11) and (J.1.12); particularly (J.1.5).

[00286] Preference is also given to mixtures comprising, as component 2, at least one active substance selected from group (K), more preferably selected from Petition 870250083202, dated 09 / 16 / 2025, pp. 271 / 317 120 / 159 compounds (K.1.41), (K.1.42), (K.1.44), (K.1.47), (K.1.57), (K.1.58) and (K.1.59); particularly selected from (K.1.41), (K.1.44), (K.1.47), (K.1.57), (K.1.58) and (K.1.59).

[00287] Biopesticides from groups L1 and / or L2 may also possess insecticidal, acaricidal, molluscicidal, pheromone, nematicidal, plant stress-reducing, plant growth-regulating, plant growth-promoting, and / or yield-enhancing activity. Biopesticides from groups L3 and / or L4 may also possess fungicidal, bactericidal, virucidal, plant defense-activating, plant stress-reducing, plant growth-regulating, plant growth-promoting, and / or yield-enhancing activity. Biopesticides from group L5 may also possess fungicidal, bactericidal, virucidal, plant defense-activating, insecticidal, acaricidal, molluscicidal, pheromone, and / or nematicidal activity.

[00288] Microbial pesticides, particularly those of groups L1, L3 and L5, include not only pure and isolated cultures of the corresponding microorganism as defined herein, but also its cell-free extract, its suspension in a whole broth culture and a culture medium containing metabolites or purified metabolites, obtained from a whole broth culture of the microorganism.

[00289] Many of these biopesticides were deposited with the deposit numbers mentioned herein (prefixes such as ATCC or DSM designate the acronym of the corresponding culture collection; for details, see, for example: http: / / www.wfcc.info / ccinfo / collection / by_acronym / ), are indicated in the literature, registered and / or commercially available: mixtures of Aureobasidium pullulans DSM 14940 and DSM 14941 isolated in 1989 in Konstanz, Germany (e.g., blastospores in BlossomProtect®, from Bio-ferm GmbH, Austria), Azospirillum brasilense Sp245 originally isolated in the wheat region of southern Brazil (Passo Fundo), at least Petition 870250083202, dated 09 / 16 / 2025, pp. 272 / 317 121 / 159 before 1980 (BR 11005; for example, GELFIX® Gramíneas from BASF Agricultural Specialties Ltda., Brazil), strains of A. brasilense Ab-V5 and Ab-V6 (for example, in AzoMax, from Novozymes BioAg Produtos para Agricultura Ltda., Quatro Barras, Brazil or Simbiose-Maíz®, from Simbiose-Agro, Brazil; Plant Soil 331,413-425, 2010), strain of Bacillus amyloliquefaciens AP-188 (NRRL B-50615 and B-50331; US ​​8,445,255); strains of B. amyloliquefaciens ssp. Plantarum, formerly also known as B. subtilis, recently, together with B. methylotrophicus and B. velezensis, classified as B. velezensis (Int. J. Syst. Evol. Microbiol. 66, 1212-1217, 2016): B. a. ssp. plantarum or B. velezensis D747 isolated from the air in Kikugawa-shi, Japan (US 2013 / 0236522 A1; FERM BP-8234; for example, Double Nickel® 55 WDG, Certis LLC, United States), B. a. ssp. plantarum or B. velezensis FZB24, isolated from the soil in Brandenburg, Germany (also known as SB3615; DSM 96-2; J. Plant Dis. Prot. 105, 181-197, 1998; for example, Taegro® from Novozyme Biologicals, Inc., United States), B. a. ssp. plantarum or B. velezensis FZB42 isolated from soil in Brandenburg, Germany (DSM 23117; J. Plant Dis. Prot. 105, 181-197, 1998; e.g., RhizoVital® 42 from AbiTEP GmbH, Germany), B. a. ssp. plantarum or B. velezensis MBI600 isolated from broad bean in Sutton Bonington, Nottinghamshire, United Kingdom, at least before 1988 (also designated 1430; NRRL B-50595; US 2012 / 0149571 A1; e.g., Integral® from BASF Corp., United States), B. a. ssp. plantarum or B.velezensis QST-713 isolated from a peach orchard in 1995 in California, United States (NRRL B-21661; for example, Serenade® MAX from Bayer Crop Science LP, United States), B. a. ssp. plantarum or B. velezensis TJ1000 isolated in 1992 in South Dakota, United States (also designated 1BE; ATCC BAA-390; CA 2471555 A1; for example, QuickRoots® from TJ Technologies, Watertown, SD, United States); B. firmus CNCM I-1582, a variant of the parental lineage EIP-N1 (CNCM I-1556) isolated from the soil of. Petition 870250083202, dated 09 / 16 / 2025, pp. 273 / 317 122 / 159 central flat area of ​​Israel (WO 2009 / 126473, US 6,406,690; e.g., Votivo® from Bayer CropScience LP, United States), B. pumilus GHA 180 isolated from apple rhizosphere in Mexico (IDAC 260707-01; e.g., PROMIX® BX from Premier Horticulture, Quebec, Canada), B. pumilus INR-7, also identified as BU-F22 and BU-F33, isolated at least before 1993 from cucumber infested with Erwinia tracheiphila (NRRL B-50185 and NRRL B-50153; US 8,445,255), B. pumilus KFP9F isolated from grass rhizosphere in South Africa at least before 2008 (NRRL B-50754; WO 2014 / 029697; for example, BAC-UP or FUSION-P from BASF Agricultural Specialities (Pty) Ltd., South Africa), B. pumilus QST 2808 was isolated from soil collected in Pompeii, Federated States of Micronesia, in 1998 (NRRL B-30087; for example, Sonata® or Ballad® Plus from Bayer Crop Science LP, United States), B. simplex ABU 288 (NRRL B-50304; US 8,445,255), B.subtilis FB17, also called UD 1022 or UD10-22, isolated from red beet roots in North America (ATCC PTA-11857; System. Appl. Microbiol. 27, 372-379, 2004; US. 2010 / 0260735; WO 2011 / 109395); B. thuringiensis ssp. aizawai ABTS-1857, isolated from soil collected from a lawn in Ephraim, Wisconsin, United States, in 1987 (also designated ABG-6346; ATCC SD-1372; for example, XenTari® from BioFa AG, Münsingen, Germany), B. t. ssp. kurstaki ABTS-351 identical to HD-1 isolated in 1967 from diseased black bollworm larvae in Brownsville, Texas, United States (ATCC SD-1275; for example, Dipel® DF from Valent BioSciences, IL, United States), B. t. ssp. kurstaki SB4, isolated from dead larvae of E. saccharina (NRRL B-50753; e.g., Beta Pro® from BASF Agricultural Specialities (Pty) Ltd., South Africa), B. t. ssp. tenebrionis NB-176-1, mutant of the NB-125 strain, wild-type strain isolated in 1982 from a dead pupa of the beetle Tenebrio molitor (DSM 5480; EP 585.215 B1; e.g., Novodor® from Valent BioSciences, Switzerland), Beauveria bassiana GHA (ATCC 74250; e.g., BotaniGard® Petition 870250083202, dated 09 / 16 / 2025, pp. 274 / 317 123 / 159 22WGP from Laverlam Int. Corp., United States), B. bassiana JW-1 (ATCC 74040; e.g., Naturalis® from CBC (Europe) Srl, Italy), B. bassiana PPRI 5339 isolated from the larva of the tortoise beetle Conchyloctenia punctata (NRRL 50757; e.g., BroadBand® from BASF Agricultural Specialities (Pty) Ltd., South Africa), Bradyrhizobium elkanii strains SEMIA 5019 (also known as 29W) isolated in Rio de Janeiro, Brazil, and SEMIA 587 isolated in 1967 in the state of Rio Grande do Sul, from an area previously inoculated with a North American isolate, and used in commercial inoculants since 1968 (Appl. Environ. Microbiol. 73 (8), 2635, 2007; e.g., GELFIX 5 from BASF Agricultural Specialties Ltda., Brazil), B. japonicum 532c, field isolate from Wisconsin, United States (Nitragin 61A152; Can. J. Plant. Sci. 70, 661666, 1990; for example, in Rhizoflo®, Histick®, Hicoat® Super from BASF Agricultural Specialties Ltd., Canada), variant B. japonicum E-109 of the USDA 138 strain (INTA E109, SEMIA 5085; Eur. J. Soil Biol. 45, 28-35, 2009; and Biol. Fertil. Soils 47, 81-89, 2011); B. japonicum strains deposited in SEMIA known through Appl. Environ. Microbiol. 73 (8), 2635, 2007: SEMIA 5079 isolated from soil in the Cerrado region, Brazil by Embrapa-Cerrados, used in commercial inoculants since 1992 (CPAC 15; for example, GELFIX 5 or ADHERE 60 from BASF Agricultural Specialties Ltd., Brazil), B. japonicum SEMIA 5080 obtained under laboratory conditions by EmbrapaCerrados in Brazil and used in commercial inoculants since 1992, which is a natural variant of SEMIA 586 (CB1809) originally isolated in the United States (CPAC 7; for example, GELFIX 5 or ADHERE 60 from BASF Agricultural Specialties Ltd., Brazil); Burkholderia sp. A396 isolated from soil in Nikko, Japan, in 2008 (NRRL B-50319; WO 2013 / 032693; Marrone Bio Innovations, Inc., United States), Coniothyrium minitans CON / M / 91-08 isolated from canola (WO 1996 / 021358; DSM 9660; e.g., Contans® WG, Intercept® WG from Bayer CropScience AG, Germany), harpin (alpha-beta) protein (Science 257, 85-88,. Petition 870250083202, dated 09 / 16 / 2025, pp. 275 / 317 124 / 159 1992; for example, Messenger® or HARP-N-Tek from Plant Health Care plc, United Kingdom), Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (J. Invertebrate Pathol. 107, 112-126, 2011; for example, Helicovex® from Adermatt Biocontrol, Switzerland; Diplomata® from Koppert, Brazil; Vivus® Max from AgBiTech Pty Ltd., Queensland, Australia), capsid nucleopolyhedrovirus isolated from Helicoverpa zea (HzSNPV) (for example, Gemstar® from Certis LLC, United States), Helicoverpa zea nucleopolyhedrovirus ABA-NPV-U (for example, Heligen® from AgBiTech Pty Ltd., Queensland, Australia), Heterorhabditis bacteriophora (for example, Nemasys® G from BASF Agricultural Specialities Limited, United Kingdom), Isaria fumosorosea Apopka-97 isolated from the purple velvet mealworm in Apopka, Florida, United States (ATCC 20874; Biocontrol. Science Technol. 22 (7), 747-761, 2012; e.g., PFR-97® or PreFeRal® from Certis LLC, United States), Metarhizium anisopliae var.anisopliae F52, also designated 275 or V275 isolated from the codling moth in Austria (DSM 3884, ATCC 90448; e.g., Met52® Novozymes Biologicals BioAg Group, Canada), Metschnikowia fructicola 277 isolated from grapes in central Israel (US 6,994,849; NRRL Y-30752; e.g., formerly Shemer® from Agrogreen, Israel), Paecilomyces ilacinus 251 isolated from infected nematode eggs in the Philippines (AGAL 89 / 030550; WO 1991 / 02051; Crop Protection 27, 352-361, 2008; e.g., BioAct® from Bayer CropScience AG, Germany, and MeloCon® from Certis, United States), Paenibacillus alvei NAS6G6 isolated from Rhizosphere of grasses in South Africa at least before 2008 (WO 2014 / 029697; NRRL B-50755; e.g., BAC-UP from BASF Agricultural Specialities (Pty) Ltd., South Africa), Paenibacillus strains isolated from soil samples from a number of locations in Europe, including Germany: P. epiphyticus Lu17015 (WO 2016 / 020371; DSM 26971), P. polymyxa ssp.plantarum Lu16774 (WO 2016 / 020371; DSM 26969), strain of P. p. ssp. plantarum Lu17007 (WO 2016 / 020371; DSM 26970); Pasteuria nishizawae Pn1. Petition 870250083202, dated 09 / 16 / 2025, pp. 276 / 317 125 / 159 isolated from a soybean field in the mid-2000s in Illinois, United States (ATCC SD-5833; Federal Register 76 (22), 5808, February 2, 2011; e.g., Clariva® PN from Syngenta Crop Protection, LLC, United States), strains of Penicillium bilaiae (also called P. bilaii) ATCC 18309 (= ATCC 74319), ATCC 20851 and / or ATCC 22348 (= ATCC 74318) originally isolated from soil in Alberta, Canada (Fertilizer Res. 39, 97-103, 1994; Can. J. Plant Sci. 78 (1), 91-102, 1998; US 5,026,417, WO 1995 / 017806; by For example, Jump Start®, Provide® from Novozymes Biologicals BioAg Group, Canada), Reynoutria sachalinensis extract (EP 0307510 B1; for example, Regalia® SC from Marrone BioInnovations, Davis, CA, United States or Milsana® from BioFa AG, Germany), Steinernema carpocapsae (for example, Millenium® from BASF Agricultural Specialities Limited, United Kingdom), S. feltiae (for example, Nemashield® from BioWorks, Inc., United States; Nemasys® from BASF Agricultural Specialities Limited, United Kingdom), Streptomyces microflavus NRRL B-50550 (WO 2014 / 124369; Bayer CropScience, Germany), Trichoderma asperelloides JM41R isolated in South Africa (NRRL 50759; also known as T. fertile; for example, Trichoplus® from BASF Agricultural Specialities (Pty) Ltd., South Africa) and T. harzianum T-22, also known as KRL-AG2 (ATCC 20847; BioControl 57, 687-696, 2012; for example,). Plantshield® from BioWorks Inc., United States, or SabrEx® from Advanced Biological Marketing Inc., Van Wert, OH, United States).

[00290] According to another embodiment of the mixtures, at least one pesticide II is selected from groups L1 to L5: L1. Microbial pesticides with fungicidal, bactericidal, virucidal and / or plant defense-activating activity: Aureobasidium pullulans DSM 14940 and DSM 14941 (L1.1), Bacillus amyloliquefaciens AP-188 (L.1.2), B. amyloliquefaciens ssp. plantarum D747 (L.1.3), B. amyloliquefaciens ssp. plantarum FZB24 (L.1.4), B. amyloliquefaciens ssp. plantarum FZB42 (L.1.5), B. Petition 870250083202, 16 / 09 / 2025, pág. 277 / 317 126 / 159 amyloliquefaciens ssp. plantarum MBI600 (L.1.6), B. amyloliquefaciens ssp. plantarum QST-713 (L.1.7), B. amyloliquefaciens ssp. plantarum TJ1000 (L.1.8), B. pumilus GB34 (L.1.9), B. pumilus GHA 180 (L.1.10), B. pumilus INR-7 (L.1.11), B. pumilus KFP9F (L.1.12), B. pumilus QST 2808 (L.1.183), B. pumilus simple ABU. (L.1.14), B. subtilis FB17 (L.1.15), Coniothyrium minitans CON / M / 91 -08 (L.1.16), Metschnikowia fructicola NRRL Y-30752 (L.1.17), Paenibacillus alvei NAS6G6 (L.1.18), P. epiticus (L.1715), Lu. P. polymyxa ssp. plantarum Lu16774 (L.1.26), lineage of P. p. ssp. plantarum Lu17007 (L.1.27), Penicillium bilaiae ATCC 22348 (L.1.19), P. bilaiae ATCC 20851 (L.1.20), Penicillium bilaiae ATCC 18309 (L.1.21), Streptomyces microflavus NRRL-1502 (L.1.52), B. Trichoderma asperelloides JM41R (L.1.23) and T. harzianum T-22 (L.1.24); L2. biochemical pesticides with fungicide, bactericide, viricide and / or vegetarian protection: harpin protein (L.2.1) and Reynoutria sachalinensis extract (L.2.2); L3. Microbial pesticides with insecticidal, acaricidal, molusquicidal, and / or nematicidal activity: Bacillus firmus I-1582 (L.3.1); B. thuringiensis ssp. aizawai ABTS-1857 (L.3.2), B. t. ssp. kurstaki ABTS-351 (L.3.3), B. t. ssp. kurstaki SB4 (L.3.4), B. t. ssp. tenebrionis NB-176-1 (L.3.5), Beauveria bassiana GHA (L.3.6), B. bassiana JW-1 (L.3.7), B. bassiana PPRI 5339 (L.3.8), Burkholderia sp. A396 (L.3.9), Helicoverpa armigera nucleopoliedrovírus (HearNPV) (L.3.10), Helicoverpa zea nucleopoliedrovírus (HzNPV) ABA-NPVU (L.3.11), Helicoverpa zea isolated capside nucleopoliedrovírus (HzSNPV) (L.3.12), Heterohabditis bacteriophora (L.3.13), Isaria fumosorosea Apopka-97 (L.3.14), Metarhizium anisopliae var. anisopliae F52 (L.3.15), Paecilomyces lilacinus 251 (L.3.16), Pasteuria nishizawae Pn1 (L.3.17), Steinernema carpocapsae (L.3.18) and S. feltiae (L.3.19); L4. Biochemical pesticides with insecticidal, acaricidal, molluscicidal, pheromone and / or nematicidal activity: cis-jasmone (L.4.1), jasmonate of Petition 870250083202, dated 09 / 16 / 2025, pp. 278 / 317 127 / 159 methyl (L.4.2) and quillaja extract (L.4.3); and L5. Microbial pesticides with plant stress-reducing, plant growth-regulating, plant growth-promoting and / or yield-enhancing activity: Azospirillum brasilense Ab-V5 and Ab-V6 (L.5.1), A. brasilense Sp245 (L.5.2), Bradyrhizobium elkanii SEMIA 587 (L.5.3), B. elkanii SEMIA 5019 (L.5.4), B. japonicum 532c (L.5.5), B. japonicum E-109 (L.5.6), B. japonicum SEMIA 5079 (L.5.7) and B. japonicum SEMIA 5080 (L.5.8).

[00291] The present invention also relates to agrochemical compositions comprising a mixture of at least one compound I (component 1) and at least one biopesticide selected from group L (component 2), particularly at least one biopesticide selected from groups L1 and L2, as described above and, if desired, at least one suitable auxiliary.

[00292] The present invention also relates to agrochemical compositions comprising a mixture of at least one compound I (component 1) and at least one biopesticide selected from group L (component 2), particularly at least one biopesticide selected from groups L3 and L4, as described above and, if desired, at least one suitable auxiliary.

[00293] Preference is also given to mixtures comprising, as pesticide II (component 2), a biopesticide selected from groups (L1), (L3) and (L5), preferably selected from the lineages indicated above as (L.1.2), (L.1.3), (L.1.4), (L.1.4), (L.1.5), (L.1.5). (L.1.6), (L.1.7), (L.1.8), (L.1.10), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.17), (L.1.18), (L.1.19), (L.1.0), (L.1.2), (L.1.2), (L.1.2). (L.1.26), (L.1.27), (L.3.1), (L.3.9), (L.3.16), (L.3.17), (L.5.1), (L.5.2), (L.5.3), (L.5.4), (L.5.5), (L.5.6), (L.5.7), (L.5.8), (L.4.4); preferably, selected from (L.1.2), (L.1.6), (L.1.7), (L.1.8), (L.1.11), Petition 870250083202, of 16 / 09 / 2025, p. 279 / 317 128 / 159 (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.19), (L.1.20), (L.1.21), (L.3.1), (L.3.9), (L.3.16), (L.3.17), (L.5.1), (L.5.2), (L.5.5), (L.5.6), (L.4.2) and (L.4.1). These mixtures are particularly suitable for treating propagation materials, i.e., for seed treatment purposes and similar soil treatment. These seed treatment mixtures are particularly suitable for producing plants such as cereals, maize, and leguminous plants such as soybeans.

[00294] Preference is also given to mixtures comprising as pesticide II (component 2) a biopesticide selected from groups (L1), (L3) and (L5), preferably selected from the lineages indicated above as (L1.1), (L.1.2), (L.1.3), (L.1.6), (L.1.6). (L.1.7), (L.1.9), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.17), (L.1.18), (L.1.22), (L.1.23), (L.1.24), (L.1.2), (L.1.2), (L.2.6), (L.1.2). (L.2.2); (L.3.2), (L.3.3), (L.3.4), (L.3.5), (L.3.6), (L.3.7), (L.3.8), (L.3.10), (L.3.11), (L.3.12), (L.3.13), (L.3.14), (L.3.15), (L.3.8), (L.3.9), (L.3.1), and (L.3.1). (L.4.2), preferably selected from (L.1.2), (L.1.7), (L.1.11), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.23), (L.3.3), (L.3.4), (L.3.6), (L.3.3), (L.3.8), (L.3.8). (L.3.10), (L.3.11), (L.3.12), (L.3.15) and (L.4.2). These mixtures are particularly suitable for foliar treatment of cultivated plants, preferably of vegetables and fruits, fruits, grapes, cereals, corn and leguminous crops, such as soybeans.

[00295] Compositions comprising mixtures of active ingredients can be prepared by common means, such as the means provided for the compositions of compounds I.

[00296] When living microorganisms, such as pesticides If the compositions of groups (L1), (L3) and (L5) are part of the compositions, these compositions can be prepared by usual means (e.g., HD Burges: Formulation of Microbial Biopesticides, Springer, 1998; WO 2008 / 002371, US 6,955,912 and US 5,422,107). Petition 870250083202, dated 09 / 16 / 2025, pp. 280 / 317 129 / 159 Examples of Synthesis Example 1 1,1-Dioxide of 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f1[1,41thiazepine] Step 1: Preparation of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol

[00297] To a solution of 1,2-difluoro-3-iodobenzene (16.8 g, 0.07 mol) in THF (150 ml) was added i-PrMgCl (2M) (36 ml, 0.073 mol) at 0 °C under N2 and the mixture was stirred at 0 °C for 30 min. Then, 6-(difluoromethyl)-5-methylnicotinaldehyde (10 g, 0.058 mol) in THF was added at 0 °C and the mixture was stirred for 4 hours at 0-20 °C under N2. TLC (PE:EtOAc=3:1) showed the termination of the reaction. The reaction mixture was cooled with aq. NH4Cl (200 ml), extracted with EtOAc (150 ml) and washed with brine (200 ml). The organic layer was dried over Na2SO4 and concentrated to yield (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol (16.7 g, crude) as a yellow solid. The title compound was used directly without further purification. 1H NMR (400 MHZ, CDCl3) Δ [PPM] = 8.38 (s, 1 H), 7.54 (s, 1 H), 7.20 - 7.25 (M, 1 H), 7.02 - 7.09 (m, 2 H), 6.45 - 6.75 (M, 1 H), 6.14 (s, 1 H), 2.40 - 2.44 (M, 3 H). Step 2: Preparation of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone

[00298] To the solution of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol (16.7 g, 0.059 mol) in THF (200 ml), MnO2 (51 g, 0.59 mol) was added and the mixture was stirred at 80 °C for 16 h. TLC (BP: EtOAc = 3:1) showed the end of the reaction. The reaction mixture was filtered and the filtrate was concentrated and purified by column chemistry (BP: EtOAc = 7:1) to yield (6(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone (12.5 g, 75%) in the form of a yellow oil. The title compound was used directly without further purification. Petition 870250083202, dated 09 / 16 / 2025, pp. 281 / 317 130 / 159 1H NMR (400 MHz, CDCl3) δ [ppm] = 8.69 (s, 1 H), 7.95 (s, 1 H), 7.27 - 7.41 (m, 2 H), 7.19 - 7.24 (m, 1 H), 6.49 - 6.84 (m, 1 H), 2.53 (S, 3 H) Step 3: 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-diHYDROBENZO[F][1,4]THIAZEPINE

[00299] To a solution of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone (1 g, 3.53 mmol) and 1-amino-2-methylpropane-2-thiol hydrochloride (751 mg, 5.30 mmol) in DMF (20 ml), CS2CO3 (3.45 g, 10.60 mmol) was added at 25 °C under N2. The mixture was then stirred at 40 °C for 2 hours. TCL (PE: EtOAc=3:1) showed the end of the reaction. The reaction mixture was cooled in H2O (15 ml) and extracted with EtOAc (10 ml x 3). The organic phase was washed with brine (10 ml x 2), dried over Na2SO4 and concentrated. The residue was purified by column chemistry (PE: EtOAc = 7:1) to generate 5-(6(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine (1.1 g, yield: 88.9%) as a yellow solid. 1H NMR (400 MHz, MeOD) δ [ppm] = 8.45 (s, 1 H), 7.80 (s, 1 H), 7.43 (td, J=7.91, 5.19 Hz, 1 H), 7.26 (t, J=8.32 Hz, 1 H), 6.93 (d, J=7.63 Hz, 1 H), 6.62 6.90 (m, 1 H), 3.21 (s, 2 H), 2.41 (s, 3 H), 1.39 (s, 6 H) Step 4: 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine 1-oxide

[00300] To a solution of 5-(6-(difluoromethyl)-5-methylpyridin-3yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine (300 mg, 0.86 mmol) in EtOH (3 ml), (NH4)6Mo?O24^4H2O (498 mg, 0.43 mmol) and H2O2 (30%, 300 mg, 0.86 mmol) were added at 25 °C under N2 and the mixture was stirred at 25 °C for 16 hours. LCMS showed the termination of the reaction. The reaction was cooled in H2O (5 ml), its pH was adjusted to 7-8 with about 10% of aq NaHCO3. Then, the resulting solution received an addition of aq Na2SO3. (20 ml), was extracted with EtOAc (3 ml x 3), washed with brine (3 ml x 2), dried over Na2SO4 and concentrated. Petition 870250083202, of 16 / 09 / 2025, p. 282 / 317 131 / 159 The residue was purified by column (PE: EtOAc = 3:1 to 1:1) to generate 1 -oxide from 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[ f 74%) in the form of yellow solid. NMR 1H (400 MHZ, MeOD) Δ [PPM] = 8.58 (D, J=1.00 Hz, 1 H), 7.89 (S, 1 H), 7.76 - 7.82 (M, 1 H), 7.49 - 7.54 (M, 1 H), 7.21 (DD, J=1.63 Hz, 63.63 Hz 1 H), 6.72 - 6.99 (M, 1 H), 4.02 (d, J=11.13 Hz, 1 H), 3.36 (d, J=11.13 Hz, 1 H), 2.51 (S, 3 H), 1.66 (S, 3 H), 1.27 (S, 3 H) Step 5: 1,1-dioxide of 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2DIMETHYL-2,3-DI-HYDROBENZOrFir1,4lTHIAZEPINE

[00301] To a solution of 5-(6-(difluoromethyl)-5-methylpyridin-3yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine (420 mg, 1.20 mmol) in EtOH (5 ml), (NH4)6Mθ7θ24·4H2θ (698 mg, 0.60 mmol) and H2O2 (30%, 1.36 mg, 11.99 mmol) was added at 25 °C under N2. The mixture was stirred at 25 °C for 16 hours. LCMS showed the termination of the reaction. The reaction was cooled in H2O (5 ml) and its pH was adjusted to 7-8 with approximately 10% aq NaHCO3. Then, aq Na2SO3 was added to the resulting solution. (20 ml), was extracted with EtOAc (5 ml x 3), washed with brine (5 ml x 2), dried over Na2SO4 and concentrated. The residue was purified by preparative HPLC to generate 1,1-dioxide of 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine (200 mg, yield: 43.5%) as a yellow solid.

[00302] The compounds listed in Table 7 below were prepared in an analogous manner. Table 7

[00303] Compounds Ex-1 to Ex-92 of formula I, wherein the meaning of R2, R3, R5, R6, R7, R8, R9 and Xn are as defined in each row: Petition 870250083202, dated 09 / 16 / 2025, pp. 283 / 317 132 / 159 LCMS: liquid chromatography-mass spectrometry; Shimadzu Nexera LC-30 LCMS-2020 (ESI+) using a Kinetex XB C18 1.7 μm (50 x 2.1 mm) HPLC column; eluent: acetonitrile / water + 0.1% trifluoroacetic acid (gradient from 5:95 to 100:0 in 1.5 min at 60 °C, flow gradient from 0.8 to 1.0 ml / min in 1.5 min) **LCMS: liquid chromatography-mass spectrometry; Shimadzu Nexera LC-30 LCMS-2020 (ESI+) using a LUX Cellulose 15 μm HPLC column (150 x 4.6 mm); eluent: acetonitrile / water + 0.1% formic acid (gradient from 50:50 to 100:0 in 10 min at 40 °C, flow rate of 0.6 ml / min) ***LCMS: liquid chromatography-mass spectrometry; Shimadzu LCMS DELIVER-220 (ESI+) using a Luna-C18 HPLC column (30 mm x 2.0 mm x 3 μm particles); Eluent: acetonitrile (+0.02% TFA) / water (+0.04%) (gradient from 5:95 to 95:5 in 1.5 min at 40 °C, flow gradient from 0.8 to 0.8 ml / min in 3 min) Rt: retention time in minutes 6 7raArBN, Z < A Á \9 T_ Γ Tf Table 7 Ex-No. R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T Ex-1 CH3 CHF 2 HH CH 3 CH3 S 9-F 350.9 1.153 Ex-2 Single diastereomer: (2R,3S) and CH3 CHF 2 H CH3 H CH3 S 9-F 350.9 1.191 Petition 870250083202, dated 09 / 16 / 2025, pp. 284 / 317 133 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T (2S,3R) Ex-3 Diastereôme ro único: (2R,3R) e (2S,3S) CH3 CHF 2 H CH3 H CH3 S 9-F 350,9 1,197 Ex-4 Mistura de isômeros: (1S,2R,3R), (1S,2S,3S), (1R,2R,3R) e (1R,2S,3S) CH3 CHF 2 H CH3 H CH3 S=O 9-F 366,9 0,972 Ex-5 CH3 CHF 2 HH CH 3 CH3 S=O 9-F 367.0 0.941 Ex-6 Mixture of isomers: (1S,2R,3S), (1S,2S,3R), (1R,2S,3R) and (1R,2R,3S) CH3 CHF 2 H CH3 H CH3 S=O 9-F 366.9 0.942 Ex-7 CH3 CHF 2 HH CH 3 CH3 S(=O) 2 9-F 383 1.03 Ex-8 Mixture of isomers: (1S,2R,3R), (1S,2S,3S), (1R,2R,3R) and (1R,2S,3S) CH3 CH3 H CH3 H CH3 S=O 9-F 330.9 0.728 Ex-9 Mixture of isomers: (1S,2R,3S), (1S,2S,3R), (1R,2S,3R) and (1R,2R,3S) CH3 CH3 H CH3 H CH3 S=O 9-F 330.9 0.702 Ex-10 Single diastereomer: (2R,3S) and (2S,3R) CH3 CH3 H CH3 H CH3 S 9-F 314.9 0.88 Ex-11 Single diastereomer: (2R,3R) and (2S,3S) CH3 CH3 H CH3 H CH3 S 9-F 314.9 0.87 Ex-12 Single diastereomer: (2S, 3S) and (2R, 3R) CH3 CHF 2 H CH3 H CH3 S(=O) 2 9-F 382.9 1.06 Ex-13 Diastereome CH3 CHF 2 H CH3 H CH3 S(=O) 2 9-F 382.9 1.06. Petition 870250083202, dated 09 / 16 / 2025, pp. 285 / 317 134 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T ro único: (2S, 3R) e (2R, 3S) Ex-14 Diastereôme ro único: (2S, 3S) e (2R, 3R) CH3 CH3 H CH3 H CH3 S(=O) 2 9-F 346,9 0,73 Ex-15 Diastereôme ro único: (2S, 3R) e (2R, 3S) CH3 CH3 H CH3 H CH3 S(=O) 2 9-F 346,9 0,72 Ex-16 Enantiômero único: (2S, 3S)** CH3 CHF 2 H CH3 H CH3 S 9-F 351,4 6.44 Ex-19 CH3 CH3 HH CH 3 CH3 S 9-F 314.9 0.88 Ex-20 CH3 CHF 2 HH CH 3 CH3 S 8F.9-F 368.9 1.22 Ex-22 CH3 CHF 2 HH CH 3 CH3 S 8OH.9 -F 366.8 1.29 Ex-23 CH3 CHF 2 HH CH 3 CH3 S=O 8F,9-F 384.8 0.99 Ex-24 CH3 CHF 2 HH CH 3 CH3 S(=O) 2 8F,9-F 400.8 1.07 Ex-25 CH3 CHF 2 HH -CH2CH2- S 9-F 348.8 1.14 Ex-26 CH3 CHF 2 HH -CH2CH2- S=O ​​9-F 364.8 0.91 Ex-27 CH3 CH3 HH CH 3 CH3 S=O 9-F 330.8 0.72 Ex-28 CH3 CH3 HH CH 3 CH3 S(=O) 2 9-F 346.8 0.73 Ex-29 CH3 CN HH CH 3 CH3 S 9-F 325.8 1.19 Ex-30 CH3 CN HH CH 3 CH3 S=O 9-F 341.8 0.93 Ex-31 Br CH3 HH CH 3 CH3 S 9-F 380.8 1.20 Ex-33 CH3 CHF 2 HH CH 3 CH3 S - 332.9 1.03 Ex-34 CH3 CHF 2 HH CH 3 CH3 S=O - 348.8 0.98 Ex-35 CH3 CHF 2 HH CH 3 CH3 S(=O) 2 - 364.8 1.02 Ex-36 Br CH3 HH CH 3 CH3 S=O 9-F 396.7 0.93. Petition 870250083202, dated 09 / 16 / 2025, pp. 286 / 317 135 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T Ex-37 CH3 CHF 2 CH 3 CH3 HHS=O 9-F 366,9 0,98 Ex-38 CH3 CHF 2 CH 3 CH3 HHS(=O) 2 9-F 382,9 1,10 Ex-39 CH3 OCH 3 HH CH 3 CH3 S 9-F 331 0,93 Ex-40 CCH CH3 HH CH 3 CH3 S 9-F 324,9 1,04 Ex-41 CH3 CHF 2 CH 3 CH3 HHS 9-F 350,9 1,11 Ex-42 CCH CH3 HH CH 3 CH3 S=O 9-F 340,9 0,86 Ex-43 CH3 OCH 3 HH CH 3 CH3 S=O 9-F 346,9 0,79 Ex-44 Enantiômero único: (2S, 3S)** CH3 CHF 2 H CH3 H CH3 S=O 9-F 367,1 3,83 Ex-45 Diastereôme ro único: (2S, 3S) e (2R, 3R) CH3 CN H CH3 H CH3 S 9-F 326 1,24 Ex-46 Diastereôme ro único: (2R, 3S) e (2S, 3R) CH3 CN H CH3 H CH3 S 9-F 326 1,22 Ex-47 Enantiômero único: (R)** CH3 CHF 2 H CH3 HHS 9-F 337,4 6,07 Ex-48 Enantiômero único: (R)** CH3 CH3 H CH3 HHS 9-F 301,5 2,55 Ex-49 Enantiomero único: (S)** CH3 CHF 2 H CH3 HHS 9-F 337,4 6,22 Ex-50 Enantiômero único: (S)** CH3 CH3 H CH3 HHS 9-F 301,5 2,49 Ex-51 CH3 CHF 2 CH 3 HHHS 9-F 336,9 1,18 Ex-52 CH3 CH3 H CH3 HHS 9-F 3010,85 Ex-57 Single enantiomer: (S)** CH3 CHF 2 H CH3 HHS=O 9-F 353.4 5.00 Ex-58 Single enantiomer: (S)** CH3 CHF 2 H CH3 HHS(=O) 2 9-F 369 5.77 Petition 870250083202, dated 09 / 16 / 2025, pp. 287 / 317 136 / 159 Ex-N° R2 R3 R5 R6 R7 R8 Z X LC_MS_M Z LC_MS_R T Ex-59 Enantiômero único: (R)** CH3 CHF 2 H CH3 H H S(=O) 2 9-F 369 5,67 Ex-60 Enantiômero único: (S)** CH3 CHF 2 H CH2CH(CH3 )2 H H S - 361,5 9,06 Ex-61 Enantiômero único: (S)** CH3 CHF 2 H CH2CH3 H H S - 333,41 8,47 Ex-62 Enantiômero único: (R)** CH3 CHF 2 H CH3 H H S=O 9-F 353 6,18 Ex-63 Enantiômero único: (S)** CH3 CHF 2 H CH2Ph H H S 9-F 413 9,90 Ex-64 Enantiômero único: (S)** CH3 CHF 2 H CH2Ph H H S - 395,1 10,16 Ex-65 Enantiômero único: (R)** Br CH3 H CH3 H H S 9-F 366,9 9,09 Ex-66 Enantiômero único: (R)** CH3 CN H CH3 H H S 9-F 312 8,11 Ex-67 Enantiômero único: (S)** CH3 CN H CH3 H H S 9-F 312 8,11 Ex-68 Enantiômero único: (S)** Br CH3 H CH3 H H S 9-F 364,9 9,13 Ex-69 Enantiômero único: (S)** CH3 CHF 2 H CH(CH3)2 H H S - 347,4 8,92 Ex-70 Enantiômero único: (S)** CH3 CHF 2 H CH2CH(CH3 )2 H H S 9-F 379,4 8,88 Ex-71 CH3 CN H CH3 H H S 9-F 312 1,20 Ex-72 Enantiômero único: (S)** CH3 CHF 2 H CH2CH3 H H S 9-F 351,5 8,40 Ex-73 Single enantiomer: (S)** CH3 CHF 2 H CH(CH3)2 HHS 9-F 365 8.84 Ex-77 Single enantiomer: (R or S)** CH3 CHF 2 HHH CH3 S - 319.2 7.30 Ex-78 Single enantiomer: (R or CH3 CHF 2 HHH CH3 S - 319.2 7.49, Petition 870250083202, dated 09 / 16 / 2025, pp. 288 / 317 137 / 159 Ex-N° R2 R3 R5 R6 R7 R8 Z X LC_MS_M Z LC_MS_R T S)** Ex-79 CH3 CHF 2 H H H CH3 S - 318,9 1,00 Ex-80 CH3 CHF 2 H H H CH3 S 9-F 337 1,12 Ex-81 Enantiômero único: (R ou S)** CH3 CHF 2 H H H CH3 S 9-F 337,2 7,59 Ex-82 Enantiômero único: (R ou S)** CH3 CHF 2 H H H CH3 S 9-F 337,4 7,74 Ex-83 CH3 CHF 2 H H H CH2CH3 S - 333 1,08 Ex-84 Enantiômero único: (R ou S)** CH3 CHF 2 H H H CH2CH3 S - 333,5 8,07 Ex-85 Enantiômero único: (R ou S)** CH3 CHF 2 H H H CH2CH3 S - 333 8,05 Ex-86 CH3 CHF 2 H H H CH2CHC H2 S - 344,9 1,13 Ex-87 Enantiômero único: (2S, 3S)** CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 397,4 8,95 Ex-88 Enantiômero único: (2R, 3R)** CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 397 9,48 Ex-89 Enantiômero único: (2R, 3S)** CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 397,4 8,90 Ex-90 Enantiômero único: (2S, 3R)** CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 397,4 9,04 Ex-91 Diastereôme ro único: (2S, 3S) e (2R, 3R) CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 396,9 1,20 Ex-92 Diastereôme ro único: (2S, 3R) e (2R,3S) CH3 CHF 2 H CH3 H CH3 S 8SCH3 , 9-F 397 1.19, Petition 870250083202, dated 09 / 16 / 2025, pp. 289 / 317 138 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T Ex-93 CH3 CHF 2 H CH3 CH 3 CH3 S 9-F 364.9 1.25 Ex-94 Unique Diasteroidal Sequence: (2S, 3S) e (2R, 3R) CH3 CHF 2 H CH3 H CH3 S 8CH3, 9-F 365 1.23 Ex-95 Unique Diasteroidal Sequence: (2S, 3R) e (2R, 3S) CH3 CHF 2 H CH3 H CH3 S 8CH3, 9-F 365 1.22 Ex-96 Unique Diasteroidal Sequence: (2S, 3S) e (2R, 3R) CH3 CHF 2 H CH3 H CH3 S 8OCH 3, 9-F 380,9 1,03 Ex-97 Unique Diasteroid: (2S, 3R) e (2R, 3S) CH3 CHF 2 H CH3 H CH3 S 8OCH 3, 9-F 380,9 1,03 Ex-98 Unique Enantiomer: (2S, 3S)** CH3 CHF 2 H CH3 H CH3 S 8OCH 3, 9-F 381,4 7,51 Ex-99 Unique Enantiomer: (2R, 3R)** CH3 CHF 2 H CH3 H CH3 S 8OCH 3, 9-F 381,4 8,15 Ex-100 Unique Enantiomer: (2R, 3S)** CH3 CHF 2 H CH3 H CH3 S 8OCH 3, 9-F 382,1 7,28 Ex-101 Enantiômero único: (2S, 3R)** CH3 CHF 2 H CH3 1,31 Ex-103 CN CH3 HH CH 3 CH3 S 9-F 325,9 1,16 Ex-104 Enantiômero único: (S)** CH3 CHF 2 HHH CH2CHC H2 S - 346 8,37 Ex-105 Single enantiomer: (R)** CH3 CHF 2 HHH CH2CHC H2 S - 346 8.26 Ex-106 Single diastereomer: (2S, 3S) and CH3 Br H CH3 H CH3 S - 362.9 1.56 Petition 870250083202, dated 09 / 16 / 2025, pp. 290 / 317 139 / 159 Ex-No. R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T (2R, 3R)** Ex-107 Single diastereomer: (2R, 3S) and (2S, 3R)** CH3 Br H CH3 H CH3 S - 362.9 1.55 Ex-108 Single enantiomer (2S, 3S) or (2R, 3R)** CH3 Br H CH3 H CH3 S - 362.9 9.21 Ex-109 Single enantiomer (2S, 3S) or (2R, 3R)** CH3 Br H CH3 H CH3 S - 362.9 9.59 Ex-110 Single enantiomer (2S, 3R) or (2R, 3S)** CH3 Br H CH3 H CH3 S - 362.9 9.36 Ex-111 Single enantiomer (2S, 3R) or (2R, 3S) CH3 Br H CH3 H CH3 S - 361 9.46 Ex-112 *** CH3 CHF 2 HHH CH2CH3 S 9-F 351.4 1.76 Ex-113 Single enantiomer (S or R)** CH3 CHF 2 HHH CH2CH3 S 9-F 351.4 8.33 Ex-114 Single enantiomer (R or S)** CH3 CHF 2 HHH CH2CH3 S 9-F 351.4 8.32 Ex-115 Single enantiomer (2S, 3R) or (2R, 3S) ** CH3 CN H CH3 H CH3 S 9-F 326 8.41 Ex-116 Enantiomer single (2S, 3R) or (2R, 3S) ** CH3 CN H CH3 H CH3 S 9-F 326 8.56 Ex-117 Single enantiomer (2S, 3S) or (2R, 3R)** CH3 CN H CH3 H CH3 S 9-F 326.2 8.94 Petition 870250083202, dated 09 / 16 / 2025, pp. 291 / 317 140 / 159 Ex-N° R2 R3 R5 R6 R7 R8 Z 2 H CH3 CH3 CH3 Enantiômero único (R)** Br CH3 H CH3 CH 3 CH3 S 9-F 394.9 10.06 Ex-123 Unique Enantiomer (S)** Br CH3 H CH3 CH 3 CH3 S 9-F 395.9 9.98 Ex-124 Unique Diastereome: (2S, 3R) e (2R, 3S)** CH3 CHF 2 H CH3 H CH2CH3 S 9-F 364.9 1.54 Ex-125 Unique Diastereome: (2S, 3S) e (2R, 3R) CH3 CHF 2 H CH3 H CH2 CHCH2 S - 358.9 1.19 Ex-126 Unique Diastereome: (2S, 3R) e (2R, 3S) CH3 CHF 2 H CH3 H CH2 CHCH2 S - 359 1.19 Ex-127 Unique Enantiomer (2R, 3S) or (2S, 3R)** CH3 CHF 2 H CH3 H CH2 CHCH2 S - 359.5 8.51 Ex-128 Unique Enantiomer (2S, 3S) or (2R, 3R)** CH3 CHF 2 H CH3 H CH3 S 8CH3, 9-F 365.5 8.69 Ex-129 Unique Enantiomer (2S, 3S) or (2R, 3R)** CH3 CHF 2 H CH3 H CH3 S 8CH3,9-F 365.5 8.66 Ex-130 Single enantiomer (2R, CH3 CHF 2 H CH3 H CH3 S 8CH3, 9-F 365.4 8.43, Petition 870250083202, dated 09 / 16 / 2025, pp. 292 / 317 141 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T 3S) or (2S, 3R)** Ex-131 Single enantiomer (2R, 3S) or (2S, 3R)** CH3 CHF 2 H CH3 H CH3 S 8CH3, 9-F 365.4 8.59 Ex-132 Single enantiomer (S)** CH3 Br H CH3 HHS 9-F 366.9 9.43 Ex-133 Single enantiomer (R)** CH3 Br H CH3 HHS 9-F 366.9 9.28 Ex-134*** CH3 CH3 H CH3 CH 3 CH3 S 9-F 329.5 1.29 Ex-135 Single enantiomer (S or R)** CH3 CH3 H CH3 CH 3 CH3 S 9-F 329.4 3.90 Ex-136 Single enantiomer (S or R)** CH3 CH3 H CH3 CH 3 CH3 S 9-F 329.5 4.02 Ex-137 CH3 CN H CH3 CH 3 CH3 S 9-F 340 1.30 Ex-138 Single enantiomer (S or R)** CH3 CN H CH3 CH 3 CH3 S 9-F 340.2 9.05 Ex-139 Single enantiomer (S or R)** CH3 CN H CH3 CH 3 CH3 S 9-F 340.2 8.87 Ex-140 Single enantiomer (2S, 3S) or (2R, 3R)** CH3 CHF 2 H CH3 H CH2 CHCH2 S - 359.5 8.66 Ex-141 Single enantiomer (2R, 3R) or (2S, 3S)** CH3 CHF 2 H CH3 H CH2 CHCH2 S - 359.5 8.53 Ex-142 Single enantiomer (2R, 3S) or (2S, 3R)** CH3 CHF 2 H CH3 H CH2 CHCH2 S - 359.5 8.58 Ex-143 Single diastereomer (2S, 3S) and (2R,CH3 CHF 2 H CH3 H CH2 CHCH2 S 9-F 376.9 1.31, Petition 870250083202, dated 09 / 16 / 2025, pp. 293 / 317 142 / 159 Ex-N° R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T 3R) Ex-144 Unique Diasteroid: (2R, 3S) e (2S, 3R)*** CH3 CHF 2 H CH3 H CH2 CHCH2 S 9-F 377.4 1.86 Ex-145 Unique Enantiomer (2S, 3S) or (2R, 3R)** CH3 CHF 2 H CH3 H CH2 CHCH2 S 9-F 377.4 8.86 Ex-146 Unique Enantiomer (2R, 3R) or (2S, 3S)** CH3 CHF 2 H CH3 H CH2 CHCH2 S 9-F 377.4 8.71 Ex-147 Enantiomerúnico (2R, 3S) or (2S, 3R)** CH3 CHF 2 H CH3 H CH2 CHCH2S 9-F 377.4 8.64 377,4 8,60 Ex-149 Enantiômero único (R ou S)** Br CN H CH3 HHS 9-F 375,8 9,32 Ex-150 Enantiômero único (R ou S)** Br CN H CH3 HHS 9-F 377,8 9,24 Ex-151 CH3 CHF 2 HHH CH2 CHCH2 S 9-F 362.9 1.25 Ex-152 Diastereôme rúnico: (2S, 3S) e (2R, 3R) CN CH3 H CH3 H CH3 S 9-F 325.9 1.19 Ex-153 Diastereôme rúnico: (2R, 3S) e (2S, 3R) CN CH3 H CH3 H CH3 S 9-F 325,9 1,18 Ex-154 Enantiômero único (S)* Br CH3 H CH2CH3 HHS 9-F 378,9 9,64 Ex-155 *** Cl CH3 -CH2-CH2- HHS 9-F 333 1,71 Petition 870250083202, dated 09 / 16 / 2025, pp. 294 / 317 143 / 159 Ex-N° R2 R3 R5 R6 R7 R8 Z X LC_MS_M Z LC_MS_R T Ex-156 *** Cl CH3 H H CH 3 CH3 S 9-F 335,4 1,70 Ex-157 Enantiômero único (2S, 3R) ou (2R, 3S)** CH3 CHF 2 H CH3 H CH2CH3 S 9-F 365,5 8,591 Ex-158 Enantiômero único (2S, 3R) ou (2R, 3S)** CH3 CHF 2 H CH3 H CH2CH3 S 9-F 365,5 8,504 Ex-159 Enantiômero único (S)** CH3 CHF 2 H CH2Ph H H S 8-F, 9-F 431 9,865 Ex-160 Enantiômero único (S ou R)** CH3 CHF 2 H H H CH2 CHCH2 S 9-F 363,5 8,367 Ex-161 Enantiômero único (S ou R)** CH3 CHF 2 H H H CH2 CHCH2 S 9-F 363,5 8,534 Ex-162 Enantiômero único (2S, 3S) ou (2R, 3R)** CN CH3 H CH3 H CH3 S 9-F 326 8,872 Ex-163 Enantiômero único (2S, 3S) ou (2R, 3R)** CN CH3 H CH3 H CH3 S 9-F 326 8,041 Ex-164 Enantiômero único (2S, 3R) ou (2R, 3S)** CN CH3 H CH3 H CH3 S 9-F 326 8,451 Ex-165 Enantiômero único (S ou R)** CN CH3 H CH3 H H S 9-F 312 8,01 Ex-166 Enantiômero único (S ou R)** CN CH3 H CH3 H H S 9-F 312 7,674 Ex-167 CHCH 2 CN H H CH 3 CH3 S 9-F 337,9 1,288 Ex-168 Br CN H H CH 3 CH3 S 9-F 389,8 1,346 Ex-169 CN CH3 -CH2-CH2- HHS 9-F 323.9 1,134, Petition 870250083202, dated 09 / 16 / 2025, pp. 295 / 317 144 / 159 Ex-No. R2 R3 R5 R6 R7 R8 ZX LC_MS_M Z LC_MS_R T Ex-170 CCH CN HH CH 3 CH3 S 9-F 1.292 1.292 Ex-171 Cl CH3 CH 3 CH3 HHS 9-F 1.097 1.097 Ex-172 Single enantiomer (S or R)** Cl CH3 HH CH 3 HS 9-F 8.51 321 Ex-173 Single enantiomer (S or R)** Cl CH3 HH CH 3 HS 9-F 8.4 321 Ex-174 Cl CH3 HH CH 3 HS 9-F 1.11 320.9 Ex-175 Cl CH3 HH CH 2 CH 3 HS 9-F 335.2 1.2 Ex-176 Single enantiomer (2S, 3R) or (2R, 3S)** CN CH3 H CH3 H CH3 S 9-F 326.4 8.09 Microtest

[00304] The active compounds were formulated separately as a standard solution with a concentration of 10,000 ppm in dimethyl sulfoxide. Example 1 Activity against gray mold Botrytis cinerea in the microplate titration test.

[00305] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Botrytis cinerea spores in an aqueous biomalt solution or yeast bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm, 7 days after inoculation.

[00306] In this test, the sample that was treated with 31 ppm of Petition 870250083202, dated 09 / 16 / 2025, pp. 296 / 317 145 / 159 active substance from example Ex-1 exhibited 0% pathogen growth.

[00307] Furthermore, in this test, samples that were treated with 31 ppm of the active substance from examples Ex-57, Ex-58, Ex-60, Ex-61, Ex-63, Ex-64, Ex-65, Ex-66, Ex-67, Ex-68, Ex-69, Ex-70, Ex-71, Ex-72, Ex-73, Ex-74, Ex-75, Ex-76, Ex-77, Ex-78, Ex-79, Ex-80, Ex-81, Ex-82, Ex-83, Ex-84 and Ex-85 exhibited up to 24% pathogen growth. Example 2 Activity against wheat leaf spot caused by Septoria tritici in the microplate titration test.

[00308] The active compounds were formulated separately as a standard solution with a concentration of 10000 ppm in dimethyl sulfoxide. The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP) and diluted with water to the indicated concentrations. A suspension of Septoria tritici spores in an aqueous solution of biomalt, yeastbactopeptone-glycerin or DOB was then added.

[00309] In this test, the sample that was treated with 31 ppm of the active substance from Example Ex-1 exhibited 9% pathogen growth.

[00310] In addition, in this test, samples that were treated with 31 ppm of the active substance from Examples Ex-61, Ex-68, Ex-72, Ex-73 and Ex-78 exhibited up to 21% pathogen growth. Example 3 Activity against Fusarium culmorum in the microplate titration test.

[00311] The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Fusarium culmorum spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a Petition 870250083202, dated 09 / 16 / 2025, pp. 297 / 317 146 / 159 chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00312] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-57, Ex-60, Ex-63, Ex-64, Ex-68, Ex-70, Ex-71, Ex-72, Ex-74, Ex-75 and Ex-80 exhibited up to 22% pathogen growth. Example 4 Activity against Alternaria alternata in the microplate titration test.

[00313] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Alternaria alternata spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00314] In this test, samples that were treated with 31 ppm of the active substance from examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 13% pathogen growth. Example 5 Activity against Alternaria solani in the microplate titration test.

[00315] The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of was then added. Petition 870250083202, dated 09 / 16 / 2025, pp. 298 / 317 147 / 159 Alternaria solani spores were inoculated in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate. The plates were placed in a vapor-saturated chamber at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00316] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 12% pathogen growth. Example 6 Activity against Cochliobolus sativus in the microplate titration test.

[00317] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Cochliobolus sativus spores in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00318] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 19% pathogen growth. Example 7 Activity against Cercospora beticula in the microplate titration test.

[00319] The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP) and diluted with water. Petition 870250083202, dated 09 / 16 / 2025, pp. 299 / 317 148 / 159 up to the indicated concentrations. A suspension of Cercospora beticula spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00320] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-25, Ex-41, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 13% pathogen growth. Example 8 Activity against Cercospora sojina in the microplate titration test.

[00321] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Cercospora sojina spores in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00322] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-31, Ex-41, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 18% pathogen growth. Example 9 Activity against Cercospora zea maydis in the microplate titration test.

[00323] The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP) and diluted. Petition 870250083202, dated 09 / 16 / 2025, pages 300 / 317 149 / 159 with water to the indicated concentrations. A suspension of Cercospora zea maydis spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00324] In this test, samples that were treated with ppm of the active substance from Examples Ex-1, Ex-2, Ex-10, Ex-11, Ex-16, Ex-20, Ex-25, Ex-31, Ex-38, Ex-40, Ex-45 and Ex-52 exhibited up to 18% pathogen growth. Example 10 Activity against Colletotrichum orbiculare in the microplate titration test.

[00325] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Colletotrichum orbiculare spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00326] In this test, samples that were treated with ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-7, Ex-8, Ex-9, Ex-10, Ex-11, Ex-13, Ex-14, Ex-15, Ex-16, Ex-19, Ex-20, Ex-23, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-30, Ex-31, Ex-33, Ex-34, Ex-35, Ex-36, Ex-38, Ex-39, Ex-40, Ex-41, Ex-42, Ex-43, Ex-44, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 18% pathogen growth. Petition 870250083202, dated 09 / 16 / 2025, pp. 301 / 317 150 / 159 Example 11 Activity against resistant isolates of Corynespora cassiicola (G143A) in the microplate titration test:

[00327] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A spore suspension of resistant isolates of Corynespora cassiicola (G143A) in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00328] In this test, samples that were treated with 31 ppm of the active substance from examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-25, Ex-41, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 17% pathogen growth. Example 12 Activity against Fusarium graminearum in the microplate titration test.

[00329] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Fusarium graminearum spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00330] In this test, the samples that were treated with 31 ppm of the active substance from Examples Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex Petition 870250083202, dated 09 / 16 / 2025, pages 302 / 317 151 / 159 31, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 14% growth of the pathogen. Example 13 Activity against Leptosphaerium nodorum in the microplate titration test.

[00331] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Leptosphaerium nodorum spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00332] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-5, Ex-7, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-22, Ex-23, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 18% pathogen growth. Example 14 Activity against Microdochium nivale in the microplate titration test.

[00333] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Microdochium nivale spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after the Petition 870250083202, dated 09 / 16 / 2025, pp. 303 / 317 152 / 159 inoculation.

[00334] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-34, Ex-35, Ex-39, Ex-40, Ex-41, Ex-42, Ex-43, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 14% pathogen growth. Example 15 Activity against Monilinia laxa in the microplate titration test.

[00335] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Monilinia laxa spores in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00336] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-6, Ex-7, Ex-8, Ex-9, Ex-10, Ex-11, Ex-12, Ex-13, Ex-14, Ex-15, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-31, Ex-33, Ex-37, Ex-38, Ex-39, Ex-40, Ex-41, Ex-42, Ex-44, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 15% pathogen growth. Example 16 Activity against Leptosphaeria maculans in the microplate titration test.

[00337] The standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Leptosphaeria maculans spores in an aqueous solution of biomalt or of was then added. Petition 870250083202, dated 09 / 16 / 2025, pp. 304 / 317 153 / 159 yeast-bactopepton-sodium acetate. The plates were placed in a vapor-saturated chamber at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00338] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-12, Ex-13, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-36, Ex-40, Ex-41, Ex-42, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 13% pathogen growth. Example 17 Activity against resistant isolates of Pyrenophora teres (F129L) in the microplate titration test.

[00339] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A spore suspension of resistant Pyrenophora teres (F129) isolates in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00340] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-5, Ex-7, Ex-10, Ex-11, Ex-12, Ex-14, Ex-16, Ex-19, Ex-20, Ex-24, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-34, Ex-35, Ex-36, Ex-39, Ex-42, Ex-43 and Ex-44 exhibited up to 20% pathogen growth. Example 18 Activity against Rhizoctonia solani in the microplate titration test.

[00341] The standard solutions were mixed according to Petition 870250083202, dated 09 / 16 / 2025, pages 305 / 317 154 / 159 ratio, pipetted onto a microtiter plate (MTP) and diluted with water to the indicated concentrations. A suspension of Rhizoctonia solani spores (F129L) in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00342] In this test, samples that were treated with 31 ppm of the active substance from Example Ex-41 exhibited up to 18% pathogen growth. Example 19 Activity against Pyricularia oryzae in the microplate titration test

[00343] Standard solutions were mixed according to the ratio, pipetted onto a microplate titration (MTP) and diluted with water to the indicated concentrations. A suspension of Pyricularia oryzae spores in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation.

[00344] In this test, the samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-6, Ex-7, Ex-8, Ex-9, Ex-10, Ex-11, Ex-12, Ex-13, Ex-14, Ex-15, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-30, Ex-31, Ex-33, Ex-34, Ex-35, Ex-36, Ex-37, Ex-38, Ex-39, Ex-40, Ex-41, Ex-43, Ex-44, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 17% growth of the pathogen. Example 20 Activity against Stemphylium sp. in the microplate titration test.

[00345] The standard solutions were mixed according to Petition 870250083202, dated 09 / 16 / 2025, pages 306 / 317 155 / 159 ratio, pipetted onto a microtiter plate (MTP) and diluted with water to the indicated concentrations. A suspension of Stemphylium sp. spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00346] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-36, Ex-37, Ex-40, Ex-41, Ex-42, Ex-46, Ex-47, Ex-49, Ex-50, Ex-51 and Ex-52 exhibited up to 14% pathogen growth. Example 21 Activity against Ustilago maydis in the microplate titration test.

[00347] Standard solutions were mixed according to the ratio, pipetted onto a micro titration plate (MTP), and diluted with water to the indicated concentrations. A suspension of Ustilago maydis spores in an aqueous solution of biomalt or yeast bactopeptone-sodium acetate was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00348] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-47 and Ex-48 exhibited up to 6% pathogen growth. Example 22 Activity against Phytophthora infestans in the microplate titration test.

[00349] The standard solutions were mixed according to Petition 870250083202, dated 09 / 16 / 2025, pp. 307 / 317 156 / 159 ratio, pipetted onto a microtiter plate (MTP) and diluted with water to the indicated concentrations. A suspension of Phytophthora infestans spores in an aqueous solution of biomalt or yeast-bactopeptone-sodium acetate was then added. The plates were placed in a vapor-saturated chamber at 18 °C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after inoculation.

[00350] In this test, samples that were treated with 31 ppm of the active substance from Examples Ex-1, Ex-2, Ex-10, Ex-19, Ex-20, Ex-23, Ex-25, Ex-29, Ex-31, Ex-33, Ex-42, Ex-47, Ex-48 and Ex-52 exhibited up to 18% pathogen growth.

[00351] The measured parameters were compared with the growth of the active compound-free control variant (100%) and with the fungus-free standard value to determine the relative growth in % of pathogens on the corresponding active compounds. Stove

[00352] The compound was dissolved in a mixture of acetone and / or dimethyl sulfoxide and the wetting / emulsifying agent Wettol, which is based on ethoxylated alkylphenols, in a solvent-emulsifier ratio (by volume) of 99 to 1, to generate a total volume of 5 ml. Water was then added to a total volume of 100 ml.

[00353] This standard solution was then diluted with the solvent-emulsifier-water mixture described until the final concentration was given in the table below. Example 1 Preventive control of Botrytis cinerea fungus on green bell pepper leaves.

[00354] Young green bell pepper seedlings were grown in Petition 870250083202, dated 09 / 16 / 2025, pages 308 / 317 157 / 159 pots were inoculated until the 4-5 leaf stage. These plants were sprayed exhaustively with the spray solution described previously, which contains the concentration of active ingredient or mixture mentioned in the table below. The following day, the plants were inoculated with an aqueous solution of biomalt or DOB containing the Botrytis cinerea spore suspension. The plants were then immediately transferred to a humid chamber. After 5 days at 22-24 °C and saturated relative humidity, the extent of fungal attack on the leaves was visually assessed as a percentage of diseased leaf area.

[00355] In this test, the samples that were treated with 125 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-5, Ex-6, Ex-7, Ex-8, Ex-9, Ex-11, Ex-12, Ex-16, Ex-19, Ex-20, Ex-24, Ex-25, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-49, Ex-50, Ex-51, Ex-52, Ex-53, Ex-56, Ex-60, Ex-61, Ex-63, Ex-64, Ex-67, Ex-68, Ex-69, Ex-70, Ex-72, Ex-73, Ex-80, Ex-81, Ex-82, Ex-83, Ex-85, Ex-86, Ex-87, Samples Ex-89, Ex-91, and Ex-92, respectively, exhibited less than 26% pathogen growth compared to untreated samples, which exhibited 90% pathogen growth. Example 2 Preventive control of Botrytis cinerea fungus on green bell pepper leaves.

[00356] Young green pepper seedlings were grown in pots until the 4-5 leaf stage. These plants were sprayed thoroughly with the spray solution described above, which contains the concentration of active ingredient or mixture mentioned in the table below. Seven days later, the plants were inoculated with an aqueous solution of biomalt or DOB containing the Botrytis cinerea spore suspension. The plants were then immediately transferred to a humid chamber. After 5 days at 22-24 °C and saturated relative humidity, the extent of fungal attack on the leaves was visually assessed as a percentage of diseased leaf area. Petition 870250083202, dated 09 / 16 / 2025, pages 309 / 317 158 / 159

[00357] In this test, samples that were treated with 125 ppm of the active substance from Examples Ex-1, Ex-7, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-31, Ex-33, Ex-39 and Ex-40, respectively, exhibited less than 20% pathogen growth compared with untreated samples, which exhibited 90% pathogen growth. Example 3 Preventive control of target spot fungi in soybeans caused by CORYNESPORA CASSIICOLA

[00358] Young soybean seedlings were grown in pots. These plants were sprayed exhaustively with the spray solution described previously, which contains the concentration of active ingredient or mixture mentioned in the table below. The following day, the treated plants were inoculated with an aqueous solution of biomalt or DOB of Corynespora cassiicola. The test plants were then grown for 8 days in a greenhouse chamber at 22 °C and 90% relative humidity. The extent of fungal attack on the leaves was visually assessed as a percentage of the diseased leaf area.

[00359] In this test, samples that were treated with 125 ppm of the active substance from Example Ex-1 exhibited less than 11% pathogen growth compared with untreated samples, which exhibited 90% pathogen growth. Example 4 Preventive control of white mold fungus in soybeans caused by Sclerotinia sclerotiorum.

[00360] Young soybean seedlings were grown in pots. These plants were sprayed exhaustively with the spray solution described previously, which contains the concentration of active ingredient or mixture mentioned in the table below. The following day, the treated plants were inoculated with a suspension containing Sclerotinia mycelium. Petition 870250083202, dated 09 / 16 / 2025, pp. 310 / 317 159 / 159 sclerotiorum. The test plants were then grown for 6 days in a greenhouse chamber at 23 °C and relative humidity of 80 to 85%. The extent of fungal attack on the leaves was visually assessed as a percentage of the area of ​​diseased leaves.

[00361] In this test, samples that were treated with 125 ppm of the active substance from Examples Ex-1, Ex-2, Ex-3, Ex-16, Ex-19, Ex-20, Ex-25, Ex-40, Ex-41, Ex-45, Ex-46, Ex-49, Ex-51, Ex-53, Ex-61, Ex-64, Ex-67, Ex-68, Ex-72, Ex-73, Ex-81, Ex-86, Ex-87, Ex-89 and Ex-91, respectively, exhibited less than 23% pathogen growth compared with untreated samples, which exhibited 90% pathogen growth. Example 5 Preventive control of white mold fungus in cabbage caused by Sclerotinia sclerotiorum.

[00362] Cabbages were grown in pots until the 14-leaf stage. These plants were sprayed to exhaustion with the spray solution described above, which contains the concentration of active ingredient or its mixture mentioned in the table below.

[00363] The plants were allowed to air dry. The following day, cabbage leaves were inoculated with 50 pl of a mixture of ground petals, methyl cellulose, water, and yeast-bacto-peptone medium (including Sclerotinia sclerotiorum spores). After 8 days at 21 °C and under 60% relative humidity, the extent of fungal attack on the leaves was visually assessed as a percentage of diseased leaf area.

[00364] In this test, samples that were treated with 125 ppm of the active substance from Examples Ex-20, Ex-25, Ex-46, Ex-49, Ex-56, Ex-68, Ex-72, Ex-80, Ex-81, Ex-82 and Ex-83, respectively, exhibited less than 23% pathogen growth compared with untreated samples, which exhibited 90% pathogen growth. Petition 870250083202, dated 09 / 16 / 2025, pp. 311 / 317

Claims

1 / 5 Claims 1. COMPOUNDS of formula I: characterized by: - ​​Y being N or CR1; - Z being S, SO or SO2; - R1 being selected independently in each case from H, halogen, CN, C1-C4 alkyl or C1-C4 alkyl halogen; - R2 being selected independently in each case from halogen, CN, C1-C6 alkyl, C1-C6 alkyl halogen, C2-C6 alkenyl, C2-C6 alkenyl halogen, C2-C6 alkynyl, C2-C6 alkynyl halogen, C1-C6 O-alkyl, C2-C6 O-alkenyl, C2-C6 O-alkynyl, C3-C6 cycloalkyl, C1-C6 S-alkyl, C2-C6 S-alkenyl or C2-C6 S-alkynyl; - R3 shall be selected, independently in each case, from halogen, CN, C1-C6 alkyl, C1-C6 alkyl halogen, C2-C6 alkenyl, C2-C6 alkenyl halogen, C2-C6 alkynyl, C2-C6 alkynyl halogen, C1-C6 O-alkyl, C2-C6 O-alkenyl, C2-C6 O-alkynyl, C3-C6 cycloalkyl, C1-C6 S-alkyl, C2-C6 S-alkenyl or C2-C6 S-alkynyl;- R4 is selected independently in each case from H, halogen, CN, C1-C4 alkyl or C1-C4 haloalkyl; - R5 is selected independently in each case from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R5a substituents; wherein - each R5a can independently be halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl;- R6 being selected, independently in each case, from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R6a substituents; where - each R6a being independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; or - R5 and R6 together form an oxo (=O) group or a thioxo (=S) group; or - R5 and R6, together with the carbon atom to which they are attached, form a saturated carbocyclic ring with 3, 4, 5 or 6 members or a saturated heterocyclic ring with 3, 4, 5 or 6 members containing 1, 2 or 3 heteroatoms selected from O and S as ring members;where the carbocyclic or heterocyclic ring is unsubstituted or carries 1, 2 or 3 R56 substituents; where - each R56 is independently halogen, C1-C6 alkyl or C1-C6 haloalkyl; - R7 is selected, independently in each case, from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, W and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R7a substituents; where - each R7a can independently be halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl;- R8 being selected, independently in each case, from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2-heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 R8a substituents; wherein - each R8a being independently halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 O-alkyl; or - R7 and R8, together with the carbon atom to which they are attached, form a saturated carbocyclic ring with 3, 4, 5 or 6 members or a saturated heterocyclic ring with 3, 4, 5 or 6 members containing 1, 2 or 3 heteroatoms selected from O and S as ring members;- X is selected independently in each case from halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, phenyl, benzyl, phenoxy, benzoxy or C1-C6 thioalkyl; wherein phenyl, benzyl, phenoxy and benzoxy may be unsubstituted or substituted by halogen, CN, C1-C6 alkyl or C1-C6 haloalkyl; and - n is 0, 1, 2 or 3; with the proviso that if Y is CR1, R5, R6, R7 and R8 may not all be H; or their N-oxides, tautomers, stereoisomers or salts acceptable for agricultural use. Petition 870250083202, dated 09 / 16 / 2025, pp. 314 / 317 4 / 5; 2. COMPOUND according to claim 1, characterized in that Y is CR1 and R1 is H.

3. COMPOUND according to any one of claims 1 or 2, characterized in that R2 is a C1-C6 alkyl.

4. COMPOUND according to any one of claims 1 to 3, characterized in that R2 is CH3.

5. COMPOUND according to any one of claims 1 to 4, characterized in that R3 is selected from C1-C6 alkyl and C1-C6 alkyl halogen.

6. COMPOUND according to any one of claims 1 to 5, characterized in that R3 is CH3 or CHF2.

7. COMPOUND according to any one of claims 1 to 6, characterized in that R4 is H.

8. COMPOUND according to any one of claims 1 to 7, characterized in that R5 and R6 are H or C1-C6 alkyl.

9. COMPOUND according to any one of claims 1 to 8, characterized by R5 and R6 forming, together with the C atoms to which they are attached, a C3-C6 cycloalkyl group or an (=O) group.

10. COMPOUND according to any one of claims 1 to 9, characterized in that R7 and R8 are H or C1-C6 alkyl.

11. COMPOUND according to any one of claims 1 to 10, characterized in that X is selected from halogen, C1-C6 alkyl, C1-C6 alkyl or C1-C6 halogen alkyl.

12. COMPOSITION characterized by comprising a compound of formula I as defined in any of claims 1 to 11 or one of its N-oxides or salts acceptable for agricultural use.

13. METHOD FOR COMBATING PHYTOPATHOGENIC FUNGI, characterized by comprising the treatment of the fungi or materials, plants, soil or seeds to be protected against fungal attacks with an effective quantity of at least one compound of formula I as defined in any of claims 1 to 11 or with a composition as defined in claim 12.

14. SEED coated with at least one compound of formula I as defined in any of claims 1 to 11 or one of its salts acceptable for agricultural use, or with a composition as defined in claim 12, characterized by being in an amount of 0.1 to 10 kg per 100 kg of seeds. Petition 870250083202, dated 09 / 16 / 2025, pp. 316 / 317