Quinolinone amide compounds and their uses.

Claims

1. Compound represented by Formula (I): or a salt thereof, characterized in that: (I); X1, X2 and X3 are independently selected from C(R) and N wherein at least one of X1, X2 and X3 is N and no more than two of X1, X2 and X3 are N; X4 is selected from C(R); each R is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8 and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =O, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more independently selected R7 substituents;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =O-, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more independently selected substituents of R7; R1 is selected from: Petition 870250085946, dated 09 / 23 / 2025, p. 13 / 79 2 / 46 hydrogen;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -NO2, =O, =S, =N(R8a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where C3-10 carbocycle and 3- to 10-membered heterocycle are each one optionally replaced with one or more independently selected substitutes from R7a;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =O-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl groups are each optionally replaced with one or more independently selected substituents from R7a;or R1 together with R2 form the C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8a, -SR8a, N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, S(O)2R8a, -NO2, =O-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 Alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7b; R2 is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8b, -SR8b, -N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, N(R8b)C(O)R8b, -C(O)OR8b, -OC(O)R8b, -N(R8b)C(O)N(R8b)2, OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =O, =S, Petition 870250085946, dated 23 / 09 / 2025, p. 14 / 79 3 / 46 =N(R8b), -CN, C3-10 carbocycle and heterocycle of 3 to 10 members, where the C3-10 carbocycle and heterocycle of 3 to 10 members are each optionally substituted with one or more substituents independently selected from R7b;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8b, -SR8b, -N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, N(R8b)C(O)R8b -N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, N(R8b)C(O)OR8b, -C(O)OR8b, -OC(O)R8b, -S(O)R8b, -S(O)2R8b, -NO2, =O-, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl groups are each optionally replaced with one or more independently selected substituents from R7b;or R1 together with R2 form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8a, -SR8a, N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, S(O)2R8a, -NO2, =O-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 Alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7b; R3 is selected from: hydrogen, halogen, -OR8c, -SR8c, -N(R8c)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from R7c; R4 is selected from: hydrogen, halogen, -OR8d, -SR8d, -N(R8d)2, -NO2 and -CN;and C1-6 alkyl optionally substituted with one or more independently selected substituents of halogen, -OR8d, -SR8d, -N(R8d)2, -NO2 and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more independently selected substituents of R7d; R4' is selected from: Petition 870250085946, dated 23 / 09 / 2025, p. 15 / 79 4 / 46 hydrogen, halogen, -OR8d, -SR8d, -N(R8d)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR8d, -SR8d, -N(R8d)2, -NO2 and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more independently selected R7d substituents;or R4 and R4' together form a C3-10 carbocycle or heterocycle of 3 to 10 members, wherein the C3-10 carbocycle or heterocycle of 3 to 10 members is optionally substituted with one or more substituents independently selected from R7d; R5 is selected from: hydrogen, halogen, -OR8e, -SR8e, -N(R8e)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle and heterocycle of 3 to 10 members, wherein the C1-6 alkyl, C310 carbocycle and heterocycle of 3 to 10 members are each optionally substituted with one or more substituents independently selected from R7e; R6 is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from R7f;Each R7, R7a, R7b, R7c, R7d, R7e and R7f is independently selected from: halogen, -OR8g, -SR8g, -N(R8g)2, -C(O)R8g, -C(O)N(R8g)2, N(R8g)C(O)R8g, -N(R8g)C(O)N(R8g)2, -OC(O)N(R8g)2, N(R8g)C(O)OR8g, -C(O)OR8g, -OC(O)R8g, -S(O)R8g, -S(O)2R8g, -NO2, =O, =S, =N(R8g) and -CN; and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8g, -SR8g, -N(R8g)2, -C(O)R8g, -C(O)N(R8g)2, -N(R8g)C(O)R8g, N(R8g)C(O)N(R8g)2, -OC(O)N(R8g)2, -N(R8g)C(O)OR8g, -C(O)OR8g, OC(O)R8g, -S(O)R8g, -S(O)2R8g, -NO2, =O, =S, =N(R8g) and -CN; Each R8, R8a, R8b, R8c, R8d, R8e, R8f, and R8g is independently selected from: hydrogen and halogen;and Petition 870250085946, dated 09 / 23 / 2025, p. 16 / 79 5 / 46 C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-10 carbocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle and C1-6 haloalkyl.

2. Compound or salt according to claim 1, characterized in that X1 is N.

3. Compound or salt according to claim 1, characterized in that X1 is C(R).

4. Compound or salt according to any one of claims 1 to 3, characterized in that X2 is N.

5. Compound or salt according to any one of claims 1 to 3, characterized in that X2 is C(R).

6. Compound or salt according to any one of claims 1 to 5, characterized in that each R is independently selected from: hydrogen, halogen, -CN, -N3, -OR8, -SR8, -N(R8)2; C1-6 alkyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents; C3-10 carbocycle and 3- to 10-membered heterocycle.

7. Compound or salt according to any one of claims 1 to 5, characterized in that each R is independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -N3, -OH, -OMe, -OEt, -O(n-Pr), -O(i-Pr), -O(i-Bu), -OCF3, NH2, -NH(Me), -NH(Et), -N(Et)2, -NH(i-Bu), -NH(Ph), -NHBn, Petition 870250085946, dated 09 / 23 / 2025, page 17 / 79 6 / 46 -CF3, -methyl, -ethyl, cyclopropyl, CH2N(CH3)2, -CCMe, -CCH, phenyl, N-morpholinyl and N-pyrrolidinyl.

8. Compound or salt according to any one of claims 1 to 7, characterized in that each R8 is independently selected from hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, isobutyl, -CF3, -CH2CF3, CH2CHF2, -CH2C(F)(Me)2 and -CH2-phenyl.

9. Compound or salt according to any one of claims 1 to 8, characterized in that R1 is hydrogen, methyl, -CH2OH, -CH2CH2OH, C(Me)2OH, -CH2OMe, or R1 together with R2 form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more substituents independently selected from -F, -COMe, -CN and methyl.

10. Compound or salt according to any one of claims 1 to 9, characterized in that R1 is methyl, -CH2OH, -CH2CH2OH, C(Me)2OH or -CH2OMe.

11. Compound or salt according to any one of claims 1 to 10, characterized in that R1 is methyl.

12. Compound or salt according to any one of claims 1 to 11, characterized in that R2 is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR8b, -C(O)R8b, -S(O)2R8b, -CN and C1-6 alkyl, where C1-6 alkyl is optionally substituted with one or more R7b; or R1 together with R2 form a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -C(O)R8a, -CN, N3 and C1-6 alkyl, where C1-6 alkyl is optionally substituted with one or more R7b.

13. Compound or salt according to any one of claims 1 to 12, characterized in that R2 is selected from phenyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, each of which is optionally substituted with one or more substituents independently selected from -F, -OH, -OMe, COMe, -SO2Me, -CN and methyl.

14. Compound or salt according to any one of claims 1 to 12, characterized in that R2 is selected from Petition 870250085946, dated 09 / 23 / 2025, page 19 / 79 8 / 46 15. Compound or salt according to any one of claims 1 to 8 or 12, characterized in that R1 and R2 are taken together to form a C3-10 carbocycle or heterocycle of 3 to 10 members selected from 16. Compound or salt according to any one of claims 1 to 8, characterized in that R1 is selected from:

17.

18. Compound or salt according to any one of claims 1 to 16, characterized in that R3 is hydrogen. Compound or salt according to any of claims 1 to 17, characterized in that R4 is independently selected from: Petition 870250085946, dated 09 / 23 / 2025, p.20 / 79 9 / 46 hydrogen, halogen, -OR8d and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR8d and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R7d; and R4' is selected from: hydrogen, halogen, -OR8d and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR8d and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R7d.

19. Compound or salt according to any one of claims 1 to 18, characterized in that each R4 is selected from hydrogen and R4' is selected from hydrogen.

20. Compound or salt according to any one of claims 1 to 18, characterized in that R4 is -F and R4' is -F.

21. Compound or salt according to any one of claims 1 to 20, characterized in that R5 is selected from: hydrogen, halogen, -OR8e, -N(R8e)2, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R7e.

22. Compound or salt according to any one of claims 1 to 21, characterized in that R5 is selected from hydrogen, -F, -Cl, -OH, -OMe, -NHMe, -CN, C1-2 alkyl and cyclopropyl, wherein the C1-2 alkyl and cyclopropyl are each optionally substituted with one or more -F.

23. Compound or salt according to any one of claims 1 to 22, characterized in that R5 is selected from hydrogen and CH3.

24. Compound or salt according to any one of claims 1 to 23, characterized in that R6 is hydrogen.

25. Compound represented by Formula (II-A): Petition 870250085946, dated 09 / 23 / 2025, p. 21 / 79 10 / 46 or a salt thereof, characterized in that: X11 is selected from C(R17a) and N; X12 is selected from C(R17b) and N; X13 is selected from C(R17c) and N; Y11 is selected from C(R17d) and N; Y12 is selected from C(R17e) and N; Each R11a, R11b, R11c, and R11d is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR19a, -SR19a, N(R19a)2, -C(O)R19a, -C(O)N(R19a)2, -N(R19a)C(O)R19a, -N(R19a)C(O)N(R19a)2, -OC(O)N(R19a)2, -N(R19a)C(O)OR19a, -C(O)OR19a, -OC(O)R19a, -S(O)R19a, and S(O)2R19a;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19a, -SR19a, -N(R19a)2, -C(O)R19a, -C(O)N(R19a)2, N(R19a)C(O)R19a, -C(O)OR19a, -OC(O)R19a, -N(R19a)C(O)N(R19a)2, OC(O)N(R19a)2, -N(R19a)C(O)OR19a, -S(O)R19a, -S(O)2R19a, -NO2, =O, =S, =N(R19a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the carbocycle C3-10 and 3- to 10-membered heterocycles are each optionally replaced with one or more independently selected substituents from R18a;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19a, -SR19a, -N(R19a)2, -C(O)R19a, C(O)N(R19a)2, -N(R19a)C(O)R19a, -N(R19a)C(O)N(R19a)2, -OC(O)N(R19a)2, N(R19a)C(O)OR19a, -C(O)OR19a, -OC(O)R19a, -S(O)R19a, -S(O)2R19a, -NO2, =O-, =S, =N(R19a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R18a; Petition 870250085946, dated 23 / 09 / 2025, p. 22 / 79 11 / 46 where when R11a, R11b and R11c are each hydrogen; then R11d is not hydrogen; where when R11b is -OCH3; then R11c is not -OMe; R12 is selected from: hydrogen, halogen, -NO2, -CN, -OR19b, -SR19b, N(R19b)2, -C(O)R19b, -C(O)N(R19b)2, -N(R19b)C(O)R19b -N(R19b)C(O)N(R19b)2, -OC(O)N(R19b)2, -N(R19b)C(O)OR19b, -C(O)OR19b, -OC(O)R19b, -S(O)R19b and S(O)2R19b;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19b, -SR19b, -N(R19b)2, -C(O)R19b, -C(O)N(R19b)2, N(R19b)C(O)R19b, -C(O)OR19b, -OC(O)R19b, -N(R19b)C(O)N(R19b)2, OC(O)N(R19b)2, -N(R19b)C(O)OR19b, -S(O)R19b, -S(O)2R19b, -NO2, =O, =S, =N(R19b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the carbocycle C3-10 and 3- to 10-membered heterocycles are each optionally replaced with one or more independently selected substituents from R18b;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19b, -SR19b, -N(R19b)2, -C(O)R19b, C(O)N(R19b)2, -N(R19b)C(O)R19b, -N(R19b)C(O)N(R19b)2, -OC(O)N(R19b)2, N(R19b)C(O)OR19b, -C(O)OR19b, -OC(O)R19b, -S(O)R19b, -S(O)2R19b, -NO2, =O-, =S, =N(R19b), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R18b; R13 is selected from: hydrogen, halogen, -OR19c, -SR19c, -N(R19c)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR19c, -SR19c, -N(R19c)2, -NO2 and -CN;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19c, -SR19c, -N(R19c)2, -C(O)R19c, C(O)N(R19c)2, -N(R19c)C(O)R19c, -N(R19c)C(O)N(R19c)2, -OC(O)N(R19c)2, Petition 870250085946, dated 09 / 23 / 2025, p. 23 / 79 12 / 46 N(R19c)C(O)OR19c, -C(O)OR19c, -OC(O)R19c, -S(O)R19c, -S(O)2R19c, -NO2, and CN; R14 is selected from: hydrogen, halogen, -OR19d, -SR19d, -N(R19d)2, -NO2 and -CN; and C1-6 alkyl which is optionally substituted with one or more substituents independently selected from halogen, -OR19d, -SR19d, N(R19d)2, -NO2 and -CN;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19d, -SR19d, -N(R19d)2, -C(O)R19d, C(O)N(R19d)2, -N(R19d)C(O)R19d, -N(R19d)C(O)N(R19d)2, -OC(O)N(R19d)2, N(R19d)C(O)OR19d, -C(O)OR19d, -OC(O)R19d, -S(O)R19d, -S(O)2R19d, -NO2, =O-, =S, =N(R19d) and -CN; R14' is selected from: hydrogen, halogen, -OR19d, -SR19d, -N(R19d)2, -NO2 and -CN; and C1-6 alkyl which is optionally substituted with one or more substituents independently selected from halogen, -OR19d, -SR19d, N(R19d)2, -NO2 and -CN; and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19d, -SR19d, -N(R19d)2, -C(O)R19d, C(O)N(R19d)2, -N(R19d)C(O)R19d, -N(R19d)C(O)N(R19d)2, -OC(O)N(R19d)2, N(R19d)C(O)OR19d, -C(O)OR19d, -OC(O)R19d, -S(O)R19d, -S(O)2R19d, -NO2, =O-, =S, =N(R19d) and -CN;or R14 together with R14' form a C3-10 carbocycle or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle or 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R18c; R15 is selected from: hydrogen, halogen, -OR19e, -SR19e, -N(R19e)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from R18d; or Petition 870250085946, dated 23 / 09 / 2025, p. 24 / 79 13 / 46 R15 together with R17a form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; or R15 together with R17b form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R18f; R16 is selected from: hydrogen, halogen, -OR19f, -SR19f, -N(R19f)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more R18e;or R16 together with R17a form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; or R16 together with R17b form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; each R17a, R17b, R17c, R17d and R17e is independently selected from: hydrogen, halogen, -OR19g, -SR19g, -N(R19g)2, -NO2, -CN, -N3; ​​and C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more R18f; or R15 together with R17a form a heterocycle of 3 to 10 members, where the 3 to 10 member heterocycle is optionally replaced with one or more R18f; or R15 together with R17b form a heterocycle of 3 to 10 members, where the 3 to 10 member heterocycle is optionally replaced with one or more R18f;or R16 together with R17a form a heterocycle of 3 to 10 members, where the 3 to 10 member heterocycle is optionally replaced with one or more R18f; or R16 together with R17b form a heterocycle of 3 to 10 members, where the 3 to 10 member heterocycle is optionally replaced with one or more R18f; or R15, R16 and R17b together form a bridging heterocycle, where the bridging heterocycle is optionally replaced with one or more R18f; Petition 870250085946, dated 23 / 09 / 2025, p. 25 / 79 14 / 46 each R18a, R18b, R18c, R18d, R18e and R18f is independently selected from: halogen, -OR19h, -SR19h, -N(R19h)2, -C(O)R19h, -C(O)N(R19h)2, N(R19h)C(O)R19h -N(R19h)C(O)N(R19h)2, -OC(O)N(R19h)2, N(R19h)C(O)OR19h, -C(O)OR19h, -OC(O)R19h, -S(O)R19h, -S(O)2R19h, -NO2, =O, =S, =N(R19h) and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR19h, -SR19h, -N(R19h)2, -C(O)R19h, -C(O)N(R19h)2, N(R19h)C(O)R19h, -N(R19h)C(O)N(R19h)2, -OC(O)N(R19h)2, N(R19h)C(O)OR19h, -C(O)OR19h, -OC(O)R19h, -S(O)R19h, -S(O)2R19h, -NO2, =O, =S, =N(R19h) and -CN; Each R19a, R19b, R19c, R19d, R19e, R19f, R19g and R19h is independently selected from: hydrogen; and C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle and C1-6 haloalkyl.

26. Compound or salt according to claim 25, characterized in that X11 is C(R17a).

27. Compound or salt according to claim 25, characterized in that X11 is N.

28. Compound or salt according to any one of claims 25 to 27, characterized in that X12 is C(R17b).

29. Compound or salt according to any of claims 25 to 27, characterized in that X12 is N. Petition 870250085946, dated 09 / 23 / 2025, p. 26 / 79 15 / 46 30. Compound or salt according to any one of claims 25 to 29, characterized in that X13 is C(R17c).

31. Compound or salt according to any one of claims 25 to 29, characterized in that X13 is N.

32. Compound or salt according to any one of claims 25, 27 to 29 or 31, characterized in that X11 and X13 are N.

33. Compound or salt according to any one of claims 25, 27 or 29-31, characterized in that X11 and X12 are N.

34. Compound or salt according to any one of claims 25 to 34, characterized in that R11a, R11b, R11c and R11d are each independently selected from hydrogen, halogen, -CN, -N3, -OR19a, C1-6 alkyl and C3-10 carbocycle; wherein when R11a, R11b and R11c are each hydrogen; then R11d is selected from: halogen, -CN, -N3, -OR19a, C1-6 alkyl and C3-10 carbocycle; wherein when R11b is -OCH3; then R11c is independently selected from: hydrogen, halogen, -CN, -N3, -OH, C1-6 alkyl and C3-10 carbocycle.

35. Compound or salt according to any one of claims 25 to 34, characterized in that R11a, R11b, R11c and R11d are each independently selected from hydrogen, -Cl, -F, -Br, -CN, N3, -OH, - r===\ NH2 νNI / OMe, methyl, cyclopropyl, -CH2N(CH3)2, CF3 and O; wherein when R11a, R11b and R11c are each hydrogen; then R11d is selected from -Cl, -F, -Br, -CN, N3, -OH, -OMe, methyl, cyclopropyl, -CHN(CH3)2 and CF3; wherein when R11b is -OCH3; then R11c is independently selected from hydrogen, -Cl, -F, -Br, -CN, N3, -OH, methyl, cyclopropyl, -CH2N(CH3)2 and CF3.

36. Compound or salt according to any one of claims 25 to 35, characterized in that R11a, R11b, R11c and R11d are each independently selected from hydrogen, -F, -CN and methyl; wherein when R11a, R11b and R11c are each hydrogen; then R11d is selected from -F, -CN and methyl.

37. Compound or salt according to any one of claims 25 to 36, characterized in that R12 is hydrogen. Petition 870250085946, dated 23 / 09 / 2025, p. 27 / 79 16 / 46 38. Compound or salt according to any of claims 25 to 37, characterized in that R13 is selected from: hydrogen, halogen, -OR19c, -SR19c, -N(R19c)2; and C1-6 alkyl which is optionally substituted with one or more substituents independently selected from halogen, -OR19c, -SR19c, N(R19c)2, -NO2 and -CN; and C3-10 carbocycle which is optionally substituted with one or more independently selected halogen substituents, -OR19c, -SR19c, N(R19c)2, -C(O)R19c, -C(O)N(R19c)2, -N(R19c)C(O)R19c, -N(R19c)C(O)N(R19c)2, -OC(O)N(R19c)2, -N(R19c)C(O)OR19c, -C(O)OR19c, -OC(O)R19c, -S(O)R19c, S(O)2R19c, -NO2, =O-, =S, =N(R19c) and -CN.

39. Compound or salt according to any one of claims 25 to 38, characterized in that R13 is selected from: hydrogen; C1-6 alkyl which is optionally substituted with one or more independently selected halogen, -OH, -OMe and CN substituents; and C3-10 carbocycle which is optionally substituted with one or more independently selected halogen, -OH, -OMe and CN substituents.

40. Compound or salt according to any one of claims 25 to 38, characterized in that R13 is selected from hydrogen, methyl, ethyl, OH, -OMe, -CF3, -C(H)F2, -N(H)Me and cyclopropyl.

41. Compound or salt according to any one of claims 25 to 40, characterized in that R14 is selected from hydrogen, C1-6 alkyl and halogen; and R14' is selected from hydrogen, C1-6 alkyl and halogen.

42. Compound or salt according to any one of claims 25 to 41, characterized in that R14 is selected from hydrogen; R14' is selected from hydrogen.

43. Compound or salt according to any one of claims 25 to 41, characterized in that R14 is selected from hydrogen; R14' is selected from methyl. Petition 870250085946, dated 09 / 23 / 2025, page 28 / 79 17 / 46 44. Compound or salt according to any one of claims 25 to 41, characterized in that R14 is selected from fluorine; and R14' is selected from fluorine.

45. Compound or salt according to any one of claims 25 to 41, characterized in that R14 and R14' together form a cyclopropane ring optionally substituted with one or more substituents selected from -F and -CH3.

46. ​​Compound or salt according to any one of claims 25 to 28 or r15 χ11 \γ12 II li N χ13 30 to 45, characterized in that R16 Rl7b forms a bridging heterocycle, wherein the bridging heterocycle is optionally replaced with one or more R18f.

47. Compound or salt according to any one of claims 25 to 45, characterized in that R15 is selected from hydrogen and C1-6 alkyl; or R15 together with R17a form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more -OR19h or C1-3 alkyl; or R15 together with R17b form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more -OR19h or C1-3 alkyl.

48. Compound or salt according to any one of claims 25 to 45, characterized in that R15 is hydrogen; or R15 together with R17a is tetrahydroisoquinoline optionally substituted with -OH or methyl; or R15 together with R17b is tetrahydroisoquinoline optionally substituted with -OH or methyl.

49. Compound or salt according to any one of claims 25 to 45, characterized in that R15 is hydrogen.

50. Compound or salt according to any one of claims 25 to 45, characterized in that R16 is selected from: hydrogen, halogen, -OR19f, -SR19f, -N(R19f)2; and C1-6 alkyl optionally substituted with one or more R18e; or Petition 870250085946, dated 09 / 23 / 2025, p. 29 / 79 18 / 46 R16 together with R17a form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; or R16 together with R17b form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f 51. Compound or salt according to any one of claims 25 to 45, characterized in that R16 is hydrogen, C11 alkyl, optionally substituted with -OH; or R16 together with R17a form a dihydrobenzofuranyl or dihydrofuropiridinyl, each of which is optionally substituted with one or more substituents independently selected from -F and -CN; or R16 together with R17b form a dihydrobenzofuranyl or dihydrofuropiridinyl, each of which is optionally substituted with one or more substituents independently selected from -F and -CN.

52. Compound or salt according to any one of claims 25 to 45, characterized in that R16 is hydrogen, methyl or CH2OH.

53. Compound or salt according to any one of claims 25 to 45, characterized in that R16 is methyl.

54. Compound or salt according to any one of claims 25 to 53, characterized in that each R17a, R17b, R17c, R17d and R17e is independently selected from: hydrogen, halogen, -OR19g and -CN; and C1-6 alkyl and C2-6 alkynyl, each of which is optionally substituted with one or more R18f; or R15 together with R17a forms a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; or R15 together with R17b forms a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R18f; or R16 together with R17a form a heterocycle of 3 to 10 members, where the heterocycle of 3 to 10 members is optionally replaced with one or more R18f; or Petition 870250085946, dated 23 / 09 / 2025, p. 30 / 79 19 / 46 R16 together with R17b form a heterocycle of 3 to 10 members, where the heterocycle of 3 to 10 members is optionally replaced with one or more R18f 55. Compound or salt according to any one of claims 25 to 54, characterized in that each R17a, R17b, R17c, R17d and R17e is independently selected from -F and -CN; or R15 together with R17b is tetrahydroisoquinoline optionally substituted with -OH; or methyl or R16 together with R17b form a dihydrobenzofuranyl or dihydrofuropiridinyl optionally substituted with one or more -F or -CN.

56. Compound or salt according to any one of claims 25 to 54, characterized in that each R17a, R17b, R17c, R17d and R17e is independently selected from hydrogen, methyl, -CCH, -F and -CN.

57. Compound or salt according to any one of claims 25 to 49, characterized in that R16 and R17a are taken together to form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more substituents selected from halogen and CN.

58. Compound or salt according to claim 57, characterized in that R16 is selected from 59. Compound represented by Formula (IV): Petition 870250085946, dated 09 / 23 / 2025, page 31 / 79 20 / 46 R43r45 r46 R47 I R48 (IV); or a salt thereof, characterized in that: RJ is a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more independently selected halogen substituents, -OR410b, -SR410b, -N(R410b)2, -C(O)R410b, C(O)N(R410b)2, -N(R410b)C(O)R410b -N(R410b)C(O)N(R410b)2, OC(O)N(R410b)2, -N(R410b)C(O)OR410b, -C(O)OR410b, -OC(O)R410b, S(O)R410b, -S(O)2R410b, -NO2, =O, =S, =N(R410b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more R49a; X41 is selected from C(R41a) and N; X42 is selected from C(R41b) and N; X43 is selected from C(R41c) and N; X44 is selected from C(R41d) and N; where no more than two of X41, X42, X43 and X44 are N; R41a, R41b, R41c and R41d are each independently selected from: hydrogen;halogen, -NO2, -N3, -CN, -OR410a, -SR410a, -N(R410a)2, -C(O)R410a, C(O)N(R410a)2, -N(R410a)C(O)R410a, -N(R410a)C(O)N(R410a)2, OC(O)N(R410a)2, -N(R410a)C(O)OR410a, -C(O)OR410a, -OC(O)R410a, S(O)R410a and -S(O)2R410a; C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410a, -SR410a, -N(R410a)2, -C(O)R410a, C(O)N(R410a)2, -N(R410a)C(O)R410a, -C(O)OR410a, -OC(O)R410a, N(R410a)C(O)N(R410a)2, -OC(O)N(R410a)2, -N(R410a)C(O)OR410a, S(O)R410a, -S(O)2R410a, -NO2, =O, =S, =N(R410a), -N3, -CN, C3-10 carbocycle and heterocycle of 3 to 10 members, where the C3-10 carbocycle and Petition 870250085946, dated 23 / 09 / 2025, p. 32 / 79 21 / 46 heterocycle of 3 to 10 members are each optionally replaced with one or more R49a;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410a, -SR410a,N(R410a)2, -C(O)R410a, -C(O)N(R410a)2, -N(R410a)C(O)R410a,N(R410a)C(O)N(R410a)2, -OC(O)N(R410a)2,N(R410a)C(O)OR410a, -C(O)OR410a, -OC(O)R410a, -S(O)R410a,S(O)2R410a, -NO2, =O, =S, =N(R410a), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more R49a; where X41 is C(H), X42 is C(H) and X43 is C(H); then R41d is not hydrogen; R43 is selected from: hydrogen, halogen, -OR410x, -SR410x, -N(R410x)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, where C1-6 alkyl, C310 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R47e;R4Z is selected from: -C(O)R410z, -C(O)N(R410z)2, -C(O)OR410z and -CN; C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410z, -SR410z, -N(R410z)2, -C(O)R410z, C(O)N(R410z)2, -N(R410z)C(O)R410z, -C(O)OR410z, -OC(O)R410z, N(R410z)C(O)N(R410z)2, -OC(O)N(R410z)2, -N(R410z)C(O)OR410z, S(O)R410z, -S(O)2R410z, -NO2, =O, =S, =N(R410z), -N3, -CN, C3-10 3- to 10-membered carbocycle and heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally replaced with one or more R49z;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410z, -SR410z, Petition 870250085946, dated 09 / 23 / 2025, p. 33 / 79 22 / 46 N(R410z)2, -C(O)R410z, -C(O)N(R410z)2, -N(R410z)C(O)R410z, N(R410z)C(O)N(R410z)2, -OC(O)N(R410z)2, N(R410z)C(O)OR410z, -C(O)OR410z, -OC(O)R410z, -S(O)R410z, S(O)2R410z, -NO2, =O, =S, =N(R410z), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more R49z; R4C is selected from: hydrogen; -C(O)R410c, -C(O)N(R410c)2, -C(O)OR410c and -CN;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410c, -SR410c, -N(R410c)2, -C(O)R410c, C(O)N(R410c)2, -N(R410c)C(O)R410c, -C(O)OR410c, -OC(O)R410c, N(R410c)C(O)N(R410c)2, -OC(O)N(R410c)2, -N(R410c)C(O)OR410c, S(O)R410c, -S(O)2R410c, -NO2, =O, =S, =N(R410c), -N3, -CN, C3-10 3- to 10-membered carbocycle and heterocycle, where C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally replaced with one or more R49c;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410c, -SR410c,N(R410c)2, -C(O)R410c, -C(O)N(R410c)2, -N(R410c)C(O)R410c,N(R410c)C(O)N(R410c)2, -OC(O)N(R410c)2,N(R410c)C(O)OR410c, -C(O)OR410c, -OC(O)R410c, -S(O)R410c,S(O)2R410c, -NO2, =O, =S, =N(R410c), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49c; R45 is selected from: hydrogen; halogen, -OR410d, -SR410d, -N(R410d)2, -C(O)R410d, -C(O)N(R410d)2, N(R410d)C(O)R410d, -C(O)OR410d, -OC(O)R410d, -N(R410d)C(O)N(R410d)2, -OC(O)N(R410d)2, -N(R410d)C(O)OR410d, -S(O)R410d, -S(O)2R410d, -NO2, N3 and -CN;Petition 870250085946, dated 09 / 23 / 2025, page. 34 / 79 23 / 46 C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410d, -SR410d, -N(R410d)2, -C(O)R410d, C(O)N(R410d)2, -N(R410d)C(O)R410d, -C(O)OR410d, -OC(O)R410d, N(R410d)C(O)N(R410d)2, -OC(O)N(R410d)2, -N(R410d)C(O)OR410d, S(O)R410d, -S(O)2R410d, -NO2, =O, =S, =N(R410d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally replaced with one or more R49d;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410d, -SR410d,N(R410d)2, -C(O)R410d, -C(O)N(R410d)2, -N(R410d)C(O)R410d,N(R410d)C(O)N(R410d)2, -OC(O)N(R410d)2,N(R410d)C(O)OR410d, -C(O)OR410d, -OC(O)R410d, -S(O)R410d,S(O)2R410d, -NO2, =O, =S, =N(R410d), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more R49d; or R45 together with R46 form a 3- to 10-membered heterocycle or C3-10 carbocycle, where the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R49d; R46 is selected from: hydrogen; halogen, -OR410e, -SR410e, -N(R410e)2, -C(O)R410e, -C(O)N(R410e)2, N(R410e)C(O)R410e, -C(O)OR410e, -OC(O)R410e, -N(R410e)C(O)N(R410e)2, OC(O)N(R410e)2, -N(R410e)C(O)OR410e, -S(O)R410e, -S(O)2R410e, -NO2, N3 and -CN;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410e, -SR410e, -N(R410e)2, -C(O)R410e, C(O)N(R410e)2, -N(R410e)C(O)R410e, -C(O)OR410e, -OC(O)R410e, N(R410e)C(O)N(R410e)2, -OC(O)N(R410e)2, -N(R410e)C(O)OR410e, S(O)R410e, -S(O)2R410e, -NO2, =O, =S, =N(R410e), -N3, -CN, C3-10 Petition 870250085946, dated 09 / 23 / 2025, p. 35 / 79 24 / 46 carbocycle and heterocycle with 3 to 10 members, where the C3-10 carbocycle and heterocycle with 3 to 10 members are each optionally replaced with one or more R49e;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410e, -SR410e, N(R410e)2, -C(O)R410e, -C(O)N(R410e)2, -N(R410e)C(O)R410e, N(R410e)C(O)N(R410e)2, -OC(O)N(R410e)2, N(R410e)C(O)OR410e, -C(O)OR410e, -OC(O)R410e, -S(O)R410e, S(O)2R410e, -NO2, =O, =S, =N(R410e), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49e; R47 is selected from: hydrogen; -C(O)R410f, -C(O)N(R410f)2, -C(O)OR410f, -S(O)R410f and -S(O)2R410f;C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR410f, -SR410f, N(R410f)2, -C(O)R410f, -C(O)N(R410f)2, -N(R410f)C(O)R410f, -C(O)OR410f, OC(O)R410f, -N(R410f)C(O)N(R410f)2, -OC(O)N(R410f)2, N(R410f)C(O)OR410f, -S(O)R410f, -S(O)2R410f, -NO2, =O, =S, =N(R410f), N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the C3-10 Carbocycles and heterocycles of 3 to 10 members are each optionally replaced with one or more R49f;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410f, -SR410f, N(R410f)2, -C(O)R410f, -C(O)N(R410f)2, -N(R410f)C(O)R410f, N(R410f)C(O)N(R410f)2, -OC(O)N(R410f)2, N(R410f)C(O)OR410f, -C(O)OR410f, -OC(O)R410f, -S(O)R410f, -S(O)2R410f, -NO2, =O, =S, =N(R410f), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49f; each R47e is independently selected from: Petition 870250085946, dated 23 / 09 / 2025, p. 36 / 79 25 / 46 halogen, -OR410y, -SR410y, -N(R410y)2, -C(O)R410y, -C(O)N(R410y)2, N(R410y)C(O)R410y, -N(R410y)C(O)N(R410y)2, -OC(O)N(R410y)2, N(R410y)C(O)OR410y, -C(O)OR410y, -OC(O)R410y, -S(O)R410y, S(O)2R410y, -NO2, =O, =S, =N(R410y) and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410y, -SR410y, -N(R410y)2, -C(O)R410y, C(O)N(R410y)2, -N(R410y)C(O)R410y, -N(R410y)C(O)N(R410y)2, OC(O)N(R410y)2, -N(R410y)C(O)OR410y, -C(O)OR410y, -OC(O)R410y, S(O)R410y, -S(O)2R410y, -NO2, =O, =S, =N(R410y) and -CN; R48 is selected from: hydrogen; -C(O)R410g, -C(O)N(R410g)2, -C(O)OR410g, -S(O)R410g and -S(O)2R410g; C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR410g, -SR410g, N(R410g)2, -C(O)R410g, -C(O)N(R410g)2, -N(R410g)C(O)R410g, -C(O)OR410g, -OC(O)R410g, -N(R410g)C(O)N(R410g)2, -OC(O)N(R410g)2, N(R410g)C(O)OR410g, -S(O)R410g, -S(O)2R410g, -NO2, =O, =S, =N(R410g), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the carbocycle C3-10 and 3- to 10-membered heterocycles are each optionally replaced with one or more R49g;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410g, -SR410g,N(R410g)2, -C(O)R410g, -C(O)N(R410g)2, -N(R410g)C(O)R410g,N(R410g)C(O)N(R410g)2, -OC(O)N(R410g)2,N(R410g)C(O)OR410g, -C(O)OR410g, -OC(O)R410g, -S(O)R410g,S(O)2R410g, -NO2, =O, =S, =N(R410g), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49g; each R49a is independently selected from: halogen, -OR410a, -SR410a, -N(R410a)2, -C(O)R410a, -C(O)N(R410a)2, N(R410a)C(O)R410a, -N(R410a)C(O)N(R410a)2, -OC(O)N(R410a)2, Petition 870250085946, dated 23 / 09 / 2025, p. 37 / 79 26 / 46 N(R410a)C(O)OR410a, -C(O)OR410a, -OC(O)R410a, -S(O)R410a, S(O)2R410a, -NO2, =O, =S, =N(R410a), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410a, -SR410a, -N(R410a)2, -C(O)R410a, C(O)N(R410a)2, -N(R410a)C(O)R410a, -N(R410a)C(O)N(R410a)2, OC(O)N(R410a)2, -N(R410a)C(O)OR410a, -C(O)OR410a, -OC(O)R410a, S(O)R410a, -S(O)2R410a, -NO2, =O, =S, =N(R410a), -N3 and -CN; Each R49z is independently selected from: halogen, -OR410z, -SR410z, -N(R410z)2, -C(O)R410z, -C(O)N(R410z)2,N(R410z)C(O)R410z, -N(R410z)C(O)N(R410z)2, -OC(O)N(R410z)2,N(R410z)C(O)OR410z, -C(O)OR410z, -OC(O)R410z, -S(O)R410z,S(O)2R410z, -NO2, =O, =S, =N(R410z), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410z, -SR410z, -N(R410z)2, -C(O)R410z, C(O)N(R410z)2, -N(R410z)C(O)R410z, -N(R410z)C(O)N(R410z)2, OC(O)N(R410z)2, -N(R410z)C(O)OR410z, -C(O)OR410z, -OC(O)R410z, S(O)R410z, -S(O)2R410z, -NO2, =O, =S, =N(R410z), -N3 and -CN; Each R49c is independently selected from: halogen, -OR410c, -SR410c, -N(R410c)2, -C(O)R410c, -C(O)N(R410c)2,N(R410c)C(O)R410c, -N(R410c)C(O)N(R410c)2, -OC(O)N(R410c)2,N(R410c)C(O)OR410c, -C(O)OR410c, -OC(O)R410c, -S(O)R410c,S(O)2R410c, -NO2, =O, =S, =N(R410c), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410c, -SR410c, -N(R410c)2, -C(O)R410c, C(O)N(R410c)2, -N(R410c)C(O)R410c, -N(R410c)C(O)N(R410c)2, OC(O)N(R410c)2, -N(R410c)C(O)OR410c, -C(O)OR410c, -OC(O)R410c, S(O)R410c, -S(O)2R410c, -NO2, =O, =S, =N(R410c), -N3 and -CN; Each R49d is independently selected from: halogen, -OR410d, -SR410d, -N(R410d)2, -C(O)R410d, -C(O)N(R410d)2, N(R410d)C(O)R410d, -N(R410d)C(O)N(R410d)2, -OC(O)N(R410d)2, Petition 870250085946, dated 09 / 23 / 2025, page. 38 / 79 27 / 46 N(R410d)C(O)OR410d, -C(O)OR410d, -OC(O)R410d, -S(O)R410d, S(O)2R410d, -NO2, =O, =S, =N(R410d), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410d, -SR410d, -N(R410d)2, -C(O)R410d, C(O)N(R410d)2, -N(R410d)C(O)R410d, -N(R410d)C(O)N(R410d)2, OC(O)N(R410d)2, -N(R410d)C(O)OR410d, -C(O)OR410d, -OC(O)R410d, S(O)R410d, -S(O)2R410d, -NO2, =O, =S, =N(R410d), -N3 and -CN; Each R49e is independently selected from: halogen, -OR410e, -SR410e, -N(R410e)2, -C(O)R410e, -C(O)N(R410e)2,N(R410e)C(O)R410e, -N(R410e)C(O)N(R410e)2, -OC(O)N(R410e)2,N(R410e)C(O)OR410e, -C(O)OR410e, -OC(O)R410e, -S(O)R410e,S(O)2R410e, -NO2, =O, =S, =N(R410e), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410e, -SR410e, -N(R410e)2, -C(O)R410e, C(O)N(R410e)2, -N(R410e)C(O)R410e, -N(R410e)C(O)N(R410e)2, OC(O)N(R410e)2, -N(R410e)C(O)OR410e, -C(O)OR410e, -OC(O)R410e, S(O)R410e, -S(O)2R410e, -NO2, =O, =S, =N(R410e), -N3 and -CN; Each R49f is independently selected from: halogen, -OR410f, -SR410f, -N(R410f)2, -C(O)R410f, -C(O)N(R410f)2, N(R410f)C(O)R410f, -N(R410f)C(O)N(R410f)2, -OC(O)N(R410f)2, N(R410f)C(O)OR410f, -C(O)OR410f, -OC(O)R410f, -S(O)R410f, -S(O)2R410f, -NO2, =O, =S, =N(R410f), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410f, -SR410f, -N(R410f)2, -C(O)R410f, C(O)N(R410f)2, -N(R410f)C(O)R410f, -N(R410f)C(O)N(R410f)2, OC(O)N(R410f)2, -N(R410f)C(O)OR410f, -C(O)OR410f, -OC(O)R410f, S(O)R410f, -S(O)2R410f, -NO2, =O, =S, =N(R410f), -N3 and -CN; Each R49g is independently selected from: halogen, -OR410g, -SR410g, -N(R410g)2, -C(O)R410g, -C(O)N(R410g)2, N(R410g)C(O)R410g, -N(R410g)C(O)N(R410g)2, -OC(O)N(R410g)2, Petition 870250085946, dated 09 / 23 / 2025, page. 39 / 79 28 / 46 N(R410g)C(O)OR410g, -C(O)OR410g, -OC(O)R410g, -S(O)R410g, S(O)2R410g, -NO2, =O, =S, =N(R410g), -N3 and -CN;and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410g, -SR410g, -N(R410g)2, -C(O)R410g, C(O)N(R410g)2, -N(R410g)C(O)R410g, -N(R410g)C(O)N(R410g)2, OC(O)N(R410g)2, -N(R410g)C(O)OR410g, -C(O)OR410g, -OC(O)R410g, S(O)R410g, -S(O)2R410g, -NO2, =O, =S, =N(R410g), -N3 and -CN; and each R410a, R410b, R410c, R410d, R410e, R410f, R410g, R410x, R410y and R410z is independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C16 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle;and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle and C1-6 haloalkyl.

60. Compound or salt according to claim 59, characterized in that X41 is N.

61. Compound or salt according to any one of claims 59 to 60, characterized in that X42 is N.

62. Compound or salt according to claim 59, characterized in that X41 is C(R41a); X42 is C(R41b); X43 is C(R41c); X44 is C(R41d). Petition 870250085946, dated 09 / 23 / 2025, p. 40 / 79 29 / 46 63. Compound or salt according to any one of claims 59 to 62, characterized in that R41a, R41b, R41c and R41d are each independently selected from: hydrogen, halogen, -N3, -CN, -OR410a, -SR410a, -N(R410a)2, -C(O)R410a, C(O)N(R410a)2, -N(R410a)C(O)R410a, N(R410a)C(O)N(R410a)2, -C(O)OR410a; C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR410a, -SR410a, -N(R410a)2, =O, =S, =N(R410a); C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more independently selected substituents of -F, -Cl, -CN, -OH, -C(O)NH2 and C1-6 alkyl.

64. Compound or salt according to any one of claims 59 to 62, characterized in that R41a, R41b, R41c and R41d are each independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -N3, -OH, O(n-Pr), -O(i-Pr), -O(i-Bu), -OCF3, -OMe, -OEt, -NH2, -NH(Me), -NH(Et), -N(Et)2, -NH(i-Bu), NH(Ph), -NHBn, -CF3, -methyl, -ethyl, cyclopropyl, -CH2N(CHa)2, -CCMe, -CCH, phenyl, N-morpholinyl and N-pyrrolidinyl.

65. Compound or salt according to any one of claims 59 to 64, characterized in that R41a, R41b, R41c and R41d are each independently selected from: hydrogen, -F, -Cl, -OH and -CN.

66. Compound or salt according to any one of claims 59 to 65, characterized in that each R410a, R410b, R410c, R410d, R410e, R410f, R410g, R410x, R410y and R410z is independently selected from: hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, isobutyl, -CF3, -CH2CF3, -CH2CHF2, CH2C(F)(Me)2 and -CH2-phenyl.

67. Compound or salt according to any one of claims 59 to 65, characterized in that two R410a are taken together to form a C3-10 carbocycle or heterocycle of 3 to 10 members.

68. Compound or salt according to any one of claims 59 to 67, characterized in that R4Z is selected from: methyl, ethyl, propyl, isopropyl, cyclopropyl, isobutyl, -CF3, -CH2CF3, -CH2CHF2, -CH2C(F)(Me)2 and CH2-phenyl.

69. Compound or salt according to any one of claims 59 to 67, characterized in that R4Z is methyl, -CH2OH, -CH2CH2OH, C(Me)2OH or -CH2OMe.

70. Compound or salt according to any one of claims 59 to 69, characterized in that R4Z is methyl.

71. Compound or salt according to any one of claims 59 to 70, characterized in that R4C is hydrogen.

72. Compound or salt according to any one of claims 59 to 71, characterized in that RJ is a 5- to 10-membered heteroaryl optionally substituted with one or more independently selected halogen substituents, -OR410b, -SR410b, -N(R410b)2, -C(O)R410b, -C(O)N(R410b)2, -N(R410b)C(O)R410b -N(R410b)C(O)N(R410b)2, -OC(O)N(R410b)2, -N(R410b)C(O)OR410b, -C(O)OR410b, -OC(O)R410b, -S(O)R410b, -S(O)2R410b, NO2, =O, =S, =N(R410b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49a.

73. Compound or salt according to any of claims 59 to 72, characterized in that RJ is a 5-membered heteroaryl optionally substituted with one or more independently selected halogen substituents, -OR410b, -SR410b, -N(R410b)2, -C(O)R410b, -C(O)N(R410b)2, -N(R410b)C(O)R410b -N(R410b)C(O)N(R410b)2, -OC(O)N(R410b)2, -N(R410b)C(O)OR410b, -C(O)OR410b, -OC(O)R410b, -S(O)R410b, -S(O)2R410b, NO2, =O, =S, =N(R410b), -N3, -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, wherein Petition 870250085946, dated 23 / 09 / 2025, p. 42 / 79 31 / 46 C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally replaced with one or more R49a.

74. Compound or salt according to any of claims 59 to 73, characterized in that RJ is a thiophene, thiazole, thiadiazole, furan, isoxazole, oxazole, oxadiazole, pyrrole, pyrazole, imidazole or triazole optionally substituted with one or more substituents independently selected from halogen, -OR410b, -N(R410b)2, -C(O)R410b, -C(O)N(R410b)2, N(R410b)C(O)R410b -OC(O)N(R410b)2, -C(O)OR410b, -OC(O)R410b, =O, =S, =N(R410b), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl groups are each optionally replaced with one or more j^49a 75. Compound or salt according to any of claims 59 to 74, characterized in that RJ is a thiophene, thiazole or oxazole optionally substituted with one or more independently selected halogen substituents, -OR410b, -N(R410b)2, -C(O)R410b, -C(O)N(R410b)2, N(R410b)C(O)R410b, -OC(O)N(R410b)2, -C(O)OR410b, -OC(O)R410b, =O, =S, =N(R410b), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more 49a 76. Compound or salt according to any one of claims 59 to 75, characterized in that R47 is hydrogen.

77. Compound or salt according to any one of claims 59 to 76, characterized in that R43 is selected from: hydrogen, -F, -Cl, -OH, -NHMe, -CN, C1-3 alkyl and cyclopropyl, wherein the C1-3 alkyl and cyclopropyl are each optionally substituted with one or more -F.

78. Compound or salt according to any one of claims 59 to 77, characterized in that R43 is selected from: hydrogen, -CH3, cyclopropyl, -F, -Cl, -CN and CF3.

79. Compound or salt according to any one of claims 59 to 78, characterized in that R43 is selected from: hydrogen and CH3.

80. Compound or salt according to any of claims 59 to 79, characterized in that R48 is selected from: hydrogen and methyl. Petition 870250085946, dated 09 / 23 / 2025, pp. 43 / 79 32 / 46 81. Compound or salt according to any one of claims 59 to 80, characterized in that R48 is selected from: hydrogen.

82. Compound or salt according to any of claims 59 to 81, characterized in that R45 is selected from: hydrogen, halogen and C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR410d and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R49d; R46 is selected from: hydrogen, halogen, C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR410d and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R49d; or R45 together with R46 form a 3- to 10-membered heterocycle or C310 carbocycle, where the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally replaced with one or more R49d.

83. Compound or salt according to any one of claims 59 to 82, characterized in that R45 R46 is selected from:

84. Compound characterized by the fact that it is selected from the group consisting of: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, Petition 870250085946, dated 09 / 23 / 2025, page. 44 / 79 33 / 46 1038, 1039, 1040, 1041, 1042, 1043, 1044, 1045, 1046, 1047, 1048, 1049, 1050, 1051, 1052, 1053, 1054, 1055, 1056, 1057, 1058, 1059, 1060, 1061, 1062, 1063, 1064, 1065, 1066, 1067, 1068, 1069, 1070, 1071, 1072, 1073, 1074, 1075, 1076, 1077, 1078, 1079, 1080, 1081, 1082, 1083, 1084, 1085,1086, 1087, 1088, 1089, 1090, 1091, 1092, 1093, 1094, 1095, 1096, 1097, 1098, 1099, 1100, 1101, 1102, 1103, 1104, 1105, 1106, 1107, 1108, 1109, 1110, 1111, 1112, 1113, 1114, 1115, 1116, 1117, 1118, 1119, 1120, 1121, 1122, 1123, 1124, 1125, 1126, 1127, 1128, 1129, 1130, 1131, 1132, 1133, 1134, 1135, 1136, 1137, 1138, 1139, 1140, 1141, 1142, 1143, 1144, 1145, 1146, 1147, 1148, 1149, 1150, 1151, 1152, 1153, 2001, 2002, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021,2022, 2023, 2024, 2025, 2026, 2027, 2028, 2029, 2030, 2033, 2034, 2035,2036, 2037, 2038, 2039, 2040, 2041, 2042, 2043, 2044, 2045, 2046, 2047,2048, 2049, 2050, 2051, 2052, 2053, 2054, 2055, 2056, 2057, 2058, 2059,2060, 2061, 2062, 2063, 2064, 2065, 2066, 2067, 2068, 2069, 2070, 2071,2072, 2073, 2074, 2075, 2076, 2077, 2078, 2079, 1153, 2501, 2502, 2503,2504, 2505, 2506, 2507, 2508, 2509, 2510, 2511, 2512, 2513, 2514, 2515,2516, 2517, 2518, 2519, 2520, 2521, 2522, 2523, 2524, 2527, 2528, 2529,2530,2531, 2532, 2533, 2534, 2535, 2536, 2537, 2538, 2539, 2540, 2541,2542, 2543, 2544, 2545, 2546, 2547, 2548, 2549, 2550, 2551, 2552, 2553,2554, 2555, 2556, 2557, 2558, 2559, 2560, 2561, 2562, 2563, 2564, 2565,2566, 2567, 2568, 2569, 2570, 2571, 2572, 2573, 2574, 2575, 2576, 2577,2578, 2579, 2580, 2581, 2582, 2583, 2584, 2585, 2586, 2587, 2588, 2590,2591, 2592, 2593, 2594, 2595, 2596, 2597, 2598, 2599, 2600, 2601, 2602,2603, 2604, 2605, 2606, 2607, 2608, 4502, 4503, 4504, 4505, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156,157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172,173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188,189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204,205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220,221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236,237, 238, 239, 240, 241, 242,243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, Petition 870250085946, dated 09 / 23 / 2025, p. 45 / 79 34 / 46 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, ​​383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433,434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444,445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460,461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476,477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492,493, 494, 495, 496, 497, 498, 499, 500, 501, 3001, 3002, 3003, 3004, 3005, 3006, 3007, 3008, 3009, 3010, 3011, 3012, 3013, 3502, 3503, 3504, 3505,3506, 3507, 3508, 3509, 3510, 3511, 3512, 3513, 3514, 3515, 3516, 3517,3518, 3519, 4001, 4002, 4003, 4004, 4005, 4006, 4007, 4008, 4009, 4010,7001, 7002, 7003, 7004, 7005, 7006, 7007, 7008, 7009, 7010, 7011, 7012,7013, 7014, 7015, 7016, 7017, 7018, 7019, 7020, 7021, 7022, 7023, 7024,7025, 7026, 7027, 7028, 7029, 7030, 7031, 7032, 7033, 7034, 7035, 7036,7037, 7038, 7039, 7040, 7041, 7042, 7043, 7044, 7045, 7046, 7047, 7048,7049, 7050, 7051, 7052, 7053, 7054, 7055, 7056, 7057, 7058, 7059, 7060,7061, 7062, 7063, 7064, 7065, 7066, 7067, 7068, 7069, 7070, 7071,7072, 7073, 7074, 7075, 7076, 7077, 7078, 7079, 7080, 7081, 7082, 7083, 7084, 7085, 7086, 7087, 7088, 7089, 7090, 7091, 7092, 7093, 7094, 4801, 4802, 4803, 4804, 4805, 4806, 4807, 4808, 4809, 4810, 4811, 4812, 4813, 4814, 4815, 4816, 4817, 4818, 4819, 4820, 4821, 4822, 4823, 4824, 4825, 4826, 4827, 4828, 4829, 4830, 4831, 4832, 4833, 4834, 4835, 4836, 4837, 4838, 4839, 4840, 4841, 4842, 4843, 4844, 4845, 4846, 4847, 4848, 4849, 4850, 3520, 3521, 3522 and 3523.

85. Method for the treatment of cardiovascular disease or a related condition characterized in that it comprises administering to an individual in need of such treatment a compound or salt as defined in any of claims 1 to 84.

86. Method for the treatment of diastolic dysfunction or a related condition, characterized in that it comprises administering to an individual in need of such treatment a compound or salt as defined in any one of claims 1 to 84.

87. Method for the treatment of a selected condition of: hypertrophic cardiomyopathy (HCM); heart failure with preserved ejection fraction (HFpEF); heart failure with intermediate ejection fraction; relaxation disorders; chamber stiffness disorders (diabetic HFpEF); dilated cardiomyopathy (DCM); ischemic cardiomyopathy; heart transplant allograft vasculopathy; restrictive cardiomyopathy; valvular heart disease (e.g., aortic stenosis - including congenital and post-AVR / TAVR forms in the elderly); left ventricular hypertrophy (LVH); right ventricular hypertrophy (RVH); acute myocardial infarction; acute revascularization; ischemia; and angina; characterized in that it comprises administering to an individual requiring such treatment a compound or salt as defined in any one of claims 1 to 84.

88. Method according to claim 87, characterized in that said heart failure with preserved ejection fraction (HFpEF) comprises one or more selected disorders of relaxation disorders and chamber stiffness disorders (diabetic HFpEF). Petition 870250085946, dated 23 / 09 / 2025, pp. 47 / 79 36 / 46 89. Method according to claim 87, characterized in that said left ventricular (LV) hypertrophy is malignant left ventricular (LV) hypertrophy.

90. Method according to claim 87, characterized in that said restrictive cardiomyopathy comprises one or more selected subgroups of inflammatory subgroups, infiltrative subgroups, storage subgroups, idiopathic / inherited subgroups, and congenital heart disease subgroups.

91. Method according to claim 90, characterized in that said inflammatory subgroups comprise one or more subgroups selected from Loefllers and EMF.

92. Method according to claim 90, characterized in that said inflammatory subgroups comprise one or more selected subgroups of amyloid, sarcoid and XRT.

93. Method according to claim 90, characterized in that said storage subgroups comprise one or more subgroups selected from hemochromatosis, Fabry disease, and glycogen storage disease.

94. Method according to claim 90, characterized in that said idiopathic / inherited subgroups comprise one or more selected subgroups of Trop I (beta myosin HC), Trop T (cardiac alpha actin) and desmin-related subgroups.

95. Method according to claim 90, characterized in that said subgroups of congenital heart disease comprise one or more selected subgroups of RV pressure overload, Tetralogy of Fallot and pulmonary stenosis.

96. Method for the treatment of hypertrophic cardiomyopathy or a related condition, characterized in that it comprises administering to an individual in need of such treatment a compound or salt as defined in any one of claims 1 to 84.

97. Method for the treatment of obstructive hypertrophic cardiomyopathy characterized in that it comprises administering to an individual Petition 870250085946, dated 09 / 23 / 2025, pp. 48 / 79 37 / 46 requiring such treatment a compound or salt as defined in any of claims 1 to 84.

98. Method for the treatment of non-obstructive hypertrophic cardiomyopathy characterized in that it comprises administering to an individual in need of such treatment a compound or salt as defined in any one of claims 1 to 84.

99. Method for the treatment of heart failure with preserved ejection fraction, characterized in that it comprises administering to an individual requiring such treatment a compound or salt as defined in any one of claims 1 to 84.

100. Method for treating left ventricular stiffness characterized in that it comprises administering to an individual requiring such treatment a compound or salt as defined in any one of claims 1 to 84.

101. Pharmaceutical composition characterized in that it comprises a compound or salt as defined in any one of items 1 to 84 and a pharmaceutically acceptable excipient.

102. Method for the treatment of a heart disease in an individual requiring such treatment characterized in that it comprises administering a therapeutically effective amount of a compound of Formula (III): R26 Formula (III) or a salt thereof, wherein: X1, X2, X3 and X4 are independently selected from C(R) and N wherein no more than two of X1, X2, X3 and X4 are N; each R is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR28, -SR28, N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28, -N(R28)C(O)N(R28)2, Petition 870250085946, dated 23 / 09 / 2025, p. 49 / 79 38 / 46 OC(O)N(R28)2, -N(R28)C(O)OR28, -C(O)OR28, -OC(O)R28, -S(O)R28 and S(O)2R28;C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28, -SR28, -N(R28)2, -C(O)R28, -C(O)N(R28)2, N(R28)C(O)R28, -C(O)OR28, -OC(O)R28, -N(R28)C(O)N(R28)2, OC(O)N(R28)2, -N(R28)C(O)OR28, -S(O)R28, -S(O)2R28, -NO2, =O, =S, =N(R28), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally replaced with one or more independently selected substitutes for R27;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28, -SR28, -N(R28)2, -C(O)R28, -C(O)N(R28)2, N(R28)C(O)R28, -N(R28)C(O)N(R28)2, -OC(O)N(R28)2, N(R28)C(O)OR28, -C(O)OR28, -OC(O)R28, -S(O)R28, -S(O)2R28, -NO2, =O-, =S, =N(R28), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl groups are each optionally replaced with one or more independently selected substituents from R27;R21 is selected from: hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, C(O)N(R28a)2, -N(R28a)C(O)R28a, -C(O)OR28a, -OC(O)R28a, N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -S(O)R28a, S(O)2R28a, -NO2, =O, =S, =N(R28a), -CN, C3-10 carbocycle and 3 to 10 heterocycle members, where the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more independently selected substituents from R27a;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, Petition 870250085946, dated 23 / 09 / 2025, p. 50 / 79 39 / 46 N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a;R22 is selected from: hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28b, -SR28b, -C(O)R28b, -C(O)N(R28b)2, N(R28b)C(O)R28b, -C(O)OR28b, -OC(O)R28b, -N(R28b)C(O)N(R28b)2, OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -S(O)R28b, -S(O)2R28b, -NO2, =O, =S, =N(R28b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the carbocycle C3-10 and 3- to 10-membered heterocycles are each optionally replaced with one or more substituents selected independently of R27b;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28b, -SR28b, -N(R28b)2, -C(O)R28b, C(O)N(R28b)2, -N(R28b)C(O)R28b, -N(R28b)C(O)N(R28b)2, -OC(O)N(R28b)2, N(R28b)C(O)OR28b, -C(O)OR28b, -OC(O)R28b, -S(O)R28b, -S(O)2R28b, -NO2, =O—, =S, =N(R28b), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;or R21 together with R22 form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, SR28a, -N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b; R23 is selected from: hydrogen, halogen, -OR28c, -SR28c, -N(R28c)2, -NO2 and -CN; and Petition 870250085946, dated 23 / 09 / 2025, p. 51 / 79 40 / 46 C1-6 alkyl optionally substituted with one or more substituents independently selected from R27c;or R21 together with R23 form a 3- to 10-membered heterocycle, which is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c;or R22 together with R23 form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, SR28a, -N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c;or R21, R22 and R23 together form a bicyclic heterocycle that is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O—, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c; R24 is selected from: hydrogen, halogen, -OR28d, -SR28d, -N(R28d)2, -NO2 and -CN;and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR28d, -SR28d, -N(R28d)2, NO2 and -CN, C3-10 carbocycle and heterocycle of 3 to 10 members, where the C3-10 Petition 870250085946, dated 23 / 09 / 2025, p. 52 / 79 41 / 46 carbocycle and heterocycle of 3 to 10 members, are each optionally substituted with one or more substituents independently selected from R24' is selected from: hydrogen, halogen, -OR28d, -SR28d, -N(R28d)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more independently selected halogen substituents, -OR28d, -SR28d, -N(R28d)2, NO2 and -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more independently selected R27d substituents;or R24 ​​and R24' together form a C3-10 carbocycle or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle or 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27d; R25 is selected from: hydrogen, halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C310 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R27e; R26 is selected from: hydrogen, halogen, -OR28f, -SR28f, -N(R28f)2, -NO2 and -CN; and C1-6 alkyl optionally substituted with one or more independently selected substituents of R27f;Each R27, R27a, R27b, R27c, R27d, R27e and R27f is independently selected from: halogen, -OR28g, -SR28g, -N(R28g)2, -C(O)R28g, -C(O)N(R28g)2, N(R28g)C(O)R28g, -N(R28g)C(O)N(R28g)2, -OC(O)N(R28g)2, N(R28g)C(O)OR28g, -C(O)OR28g, -OC(O)R28g, -S(O)R28g, -S(O)2R28g, -NO2, =O, =S, =N(R28g) and -CN; and C1-3 alkyl, C2-3 alkenyl and C2-3 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28g, -SR28g, -N(R28g)2, -C(O)R28g, -C(O)N(R28g)2, N(R28g)C(O)R28g, -N(R28g)C(O)N(R28g)2, -OC(O)N(R28g)2, Petition 870250085946, dated 23 / 09 / 2025, p. 53 / 79 42 / 46 N(R28g)C(O)OR28g, -C(O)OR28g, -OC(O)R28g, -S(O)R28g, -S(O)2R28g, -NO2, =O, =S, =N(R28g) and -CN; each R28, R28a, R28b, R28c, R28d, R28e, R28f and R28g is independently selected from: hydrogen and halogen;and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-10 carbocycle, each of which is optionally substituted with one or more independently selected substituents of halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle and C1-6 haloalkyl.

103. Method according to claim 102, characterized in that the compound of Formula (III) is not 104. Method according to claim 102, characterized in that: R21 is selected from: hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, -C(O)R28a, -C(O)N(R28a)2, N(R28a)C(O)R28a, -C(O)OR28a, -OC(O)R28a, -N(R28a)C(O)N(R28a)2, OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -S(O)R28a, -S(O)2R28a, -NO2, =O, =S, =N(R28a), -CN, C3-10 carbocycle and heterocycle of 3 to 10 members, wherein the C3-10 carbocycle and heterocycle of 3 to 10 members are each optionally substituted with one or more substituents independently selected from R27a;and Petition 870250085946, dated 09 / 23 / 2025, p. 54 / 79 43 / 46 C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a;R22 is selected from: hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28b, -SR28b, -C(O)R28b, -C(O)N(R28b)2, N(R28b)C(O)R28b, -C(O)OR28b, -OC(O)R28b, -N(R28b)C(O)N(R28b)2, OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -S(O)R28b, -S(O)2R28b, -NO2, =O, =S, =N(R28b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, where the carbocycle C3-10 and 3- to 10-membered heterocycles are each optionally replaced with one or more substituents selected independently of R27b;and C3-10 carbocycle and heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28b, -SR28b, -N(R28b)2, -C(O)R28b, C(O)N(R28b)2, -N(R28b)C(O)R28b, -N(R28b)C(O)N(R28b)2, -OC(O)N(R28b)2, N(R28b)C(O)OR28b, -C(O)OR28b, -OC(O)R28b, -S(O)R28b, -S(O)2R28b, -NO2, =O-, =S, =N(R28b), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 Alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;or R21 together with R22 form a C3-10 carbocycle or heterocycle of 3 to 10 members, each of which is optionally substituted with one or more independently selected halogen substituents, -OR28a, SR28a, -N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =O-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, where C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are Petition 870250085946, dated 23 / 09 / 2025, p. 55 / 79 44 / 46 each optionally replaced with one or more substituents selected independently of R27b.; 105. Method according to claim 102, characterized in that: R25 is selected from: hydrogen, halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, -CN and C1-6 alkyl, wherein the C1-6 alkyl is optionally replaced with one or more R27e.

106. A method according to any one of claims 102 to 105, characterized in that the cardiovascular disease or a related condition is selected from: hypertrophic cardiomyopathy (HCM); heart failure with preserved ejection fraction (HFpEF); heart failure with intermediate ejection fraction relaxation disorders; chamber stiffness disorders (diabetic HFpEF); dilated cardiomyopathy (DCM); ischemic cardiomyopathy; heart transplant allograft vasculopathy; restrictive cardiomyopathy; valvular heart disease (e.g., aortic stenosis - including congenital and post-AVR / TAVR forms in the elderly); left ventricular hypertrophy (LVH); right ventricular hypertrophy (RVH); acute myocardial infarction; acute revascularization; ischemia; and angina.

107. Method according to claim 106, characterized in that said heart failure with preserved ejection fraction (HFpEF) comprises one or more selected disorders of relaxation disorders and chamber stiffness disorders (diabetic HFpEF).

108. Method according to claim 106, characterized in that said left ventricular (LV) hypertrophy is malignant left ventricular (LV) hypertrophy. Petition 870250085946, dated 09 / 23 / 2025, pp. 56 / 79 45 / 46 109. Method according to claim 106, characterized in that said restrictive cardiomyopathy comprises one or more selected subgroups of inflammatory subgroups, infiltrative subgroups, storage subgroups, idiopathic / inherited subgroups, and congenital heart disease subgroups.

110. Method according to claim 106, characterized in that said inflammatory subgroups comprise one or more subgroups selected from Loefllers and EMF.

111. Method according to claim 106, characterized in that said inflammatory subgroups comprise one or more selected subgroups of amyloid, sarcoid and XRT.

112. Method according to claim 106, characterized in that said storage subgroups comprise one or more subgroups selected from hemochromatosis, Fabry disease, and glycogen storage disease.

113. Method according to claim 106, characterized in that said idiopathic / inherited subgroups comprise one or more selected subgroups of Trop I (beta myosin HC), Trop T (cardiac alpha actin) and desmin-related subgroups.

114. Method according to claim 106, characterized in that said subgroups of congenital heart disease comprise one or more selected subgroups of RV pressure overload, Tetralogy of Fallot and pulmonary stenosis.

115. A method according to any one of claims 106 to 114, characterized in that the cardiovascular disease or a related condition is hypertrophic cardiomyopathy.

116. A method according to any one of claims 106 to 114, characterized in that the cardiovascular disease or a related condition is obstructive hypertrophic cardiomyopathy.

117. Method according to any one of claims 106 to 114, characterized in that the cardiovascular disease or a related condition is non-obstructive hypertrophic cardiomyopathy. Petition 870250085946, dated 09 / 23 / 2025, pp. 57 / 79 46 / 46 118. A method according to any one of claims 106 to 114, characterized in that the cardiovascular disease or a related condition is heart failure with preserved ejection fraction.

119. A method according to any one of claims 106 to 114, characterized in that the cardiovascular disease or related condition is left ventricular stiffness.