Enhanced Waxy Distribution Forms for Oily Agronomic Active Ingredients and Preparation Method

Description

1 / 39 Enhanced Waxy Distribution Forms for Oily Agronomic Active Ingredients and Preparation Method Description Field of Invention

[001] The invention relates to the field of products used in agronomy, such as insecticides, fungicides, antimicrobials, herbicides and the like, and to methods for increasing their effectiveness. State of the Art

[002] Pesticides and biocides are normally administered by spraying or topical use (biocides). However, their use has a negative effect on the environment (pesticide spraying) in both the short and long term, through increased environmental pollution or, when biocides are used in contact with the skin (repellent body solution), through increased potential negative dermal effects such as sensitization and allergy. To mitigate these disadvantages, the active substance of pesticides and biocides can be encapsulated.

[003] Many encapsulation techniques are reported, particularly through the use of synthetic polymers to obtain a slow release of the active ingredients contained in the capsules. Thus, formulations containing microcapsules with a wide variety of characteristics and their related processes for obtaining the microcapsules are known in the art. By Petition 870250090272, dated 03 / 10 / 2025, page 61 / 124 2 / 39 For example, Wege PJ in “Proceedings of the Third International Conference on Urban Pests” describes polyurea-walled microcapsules containing lambda-cyhalothrin; Sheu EY in “2000 BCPC Symposium Proceedings No. 74” describes the rapid-release microencapsulation technology of lambda-cyhalothrin based on interfacial polymerization through the use of polymethylene-polyphenylisocyanate (PMPPI) and toluene diisocyanate (TDI) as a crosslinking agent. Document EP183,999 describes microcapsules containing pyrethrum extract (an insecticide) obtained through the use of synthetic polymers such as polyurea, polyesters, polyamides, and so on; US patent 10,271,547 B2 describes microcapsules composed of waxy-lipid cores containing pheromones and encapsulated in copolymers of (meth)acrylic acids and alkyl acrylates supplemented with hydrophobic macromonomers; the microcapsules are suspended in an aqueous medium for administration.Additional microcapsules prepared in a similar manner and containing insecticides are also described in documents GB 2,187,957, EP 322,820 and EP 902,724, in Gimeno M., “J. Environ. Sci. Health”, 1996, B31 (3), 407 to 420, Finch CA “Encapsulation and controlled release”, Royal Society of Chemistry 1993, 138, 1 to 12, in documents EP183999, WO 2003 / 051116, US2003 / 0119675, US2002 / 0158356 A1, WO 00 / 04776, EP 322820.

[004] Nowadays there are many concerns related Petition 870250090272, dated 03 / 10 / 2025, page 62 / 124 3 / 39 to microplastics. The term microplastic is typically considered to refer to small, usually microscopic, solid particles made of a synthetic polymer. They are associated with long-term persistence in the environment if released, as they are very resistant to (bio)degradation and are virtually impossible to remove from the environment after release.

[005] As most encapsulated products and related formulations on the agricultural market are generally composed of synthetic polymers belonging to the chemical classes mentioned above and related pollution is playing a key role in environmental contamination, the European Chemicals Agency (ECHA) is preparing a restriction dossier on microplastics based on Article 69(1) of the REACH Regulation.

[006] For this reason, it is crucial to find new strategies for encapsulating pesticides and biocides using natural and biodegradable encapsulating materials. There are different approaches that can be adopted, such as polysaccharide-based microencapsulants, protein-based microencapsulants, lipid / liposome-based microencapsulants, cell-based microencapsulants, and mineral-based microencapsulants. For example, document WO2007 / 063267 relates to compositions comprising terpenes and Petition 870250090272, dated 03 / 10 / 2025, page 63 / 124 4 / 39 Hollow glucan particles or cell wall particles and methods for preparing such compositions. The compositions increase the stability and activity of the terpene and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. Document WO2016 / 124927 describes a composition comprising a microparticle component and a highly potent active agent encapsulated in the microparticle. Document WO2010 / 101821 describes several microencapsulated insecticidal formulations for the control of pests such as aphids and fall armyworm. Document WO 2006 / 077568 refers to a novel agricultural “green” formulation comprising at least one encapsulated volatile essential oil and a non-volatile carrier in which said encapsulated volatile essential oil is carried.Document EP815144 relates to a novel composition consisting of a gelling agent and glucan and its use as a nutritional supplement, cosmetic product, etc., as a medical device or a pharmaceutical product incorporated into a medical device. Document WO2018 / 201161 describes platforms, compositions and methods for encapsulating agricultural compounds in achromosomal and / or anucleated cells. Document US5009898 relates to antimicrobial hydroxyapatite powders, in which metal ions that have antimicrobial properties, such as silver, copper and zinc ions, or antimicrobial agents, are present. Petition 870250090272, dated 03 / 10 / 2025, page 64 / 124 5 / 39 organic compounds, such as hinochitol, tannin, lysozyme, protamine, and sorbic acid, are included in hydroxyapatite powders that have good affinity for a living body. Document WO2017 / 134308 describes a process for the production of lignin nanoparticles comprising a hydrophobic active agent. Document US 2021 / 0244034 describes a solid composition comprising a volatile active composition, for example, an essential oil, absorbed in a waxy sorbent; the waxy sorbent is predominant, stated as representing 50% or more of the entire solid composition, while the active composition represents 50% or less: the examples describe wax-based compositions that have an oil:wax ratio of 0.6:1. Document CN1156694 describes a highly fluid antifungal coating composition containing beeswax, citronella oil, and olive oil. The granular pesticide compositions are known from US documents 5,827.540 and US 2006 / 0099233: these documents describe granules made massively of an inorganic carrier; the active agent is applied externally as a coating, in a mixture with small amounts of a waxy substance. Document US 2003 / 0108584 describes a premixed powder for agronomic use, including highly dispersed silica, small amounts of wax, and even small amounts of oil.

[007] Aqueous emulsions whose lipophilic component Petition 870250090272, dated 03 / 10 / 2025, page 65 / 124 6 / 39 includes waxy substances and oils that are known for application in technical fields other than agronomy: compare with, for example, the publication “Cellulose”, 2020, 17, pages 9711 to 9723 (used for textile impregnation), document US 6,358,623 (used for treating household surfaces such as furniture, floors, etc.), document CN106479381 (used as shoe polish); none of these products are intended for the preparation of granules and / or include inorganic carriers.

[008] Document KR 20210000412A describes a barrier composition for blocking murine animals comprising: 1 to 24% by weight of a mouse repellent component; 15 to 40% by weight of a physical stabilizer, 2 to 10% by weight of an odor regulator and 35 to 70% by weight of a binder. Document CN 1301488A describes an electric mosquito coil comprising 2 to 4 parts of synthetic insecticide, 0.1 to 0.3 parts of lemon eucalyptus oil, 0.2 to 0.4 parts of citronella oil, 18 to 25 parts of clay and 4 to 6 parts of wax. Document CN 110692649A describes an insecticidal ointment comprising, among other things, 5 to 75 parts of solvent, 5 to 60 parts of a molded product, 20 to 80 parts of filler, and 5 to 45 parts of medicament. Document CN 108967423A describes a slow-release water-containing emulsion with low amounts of lipophilic solvent.

[009] The Applicant is actively involved in the area Petition 870250090272, dated 03 / 10 / 2025, page 66 / 124 7 / 39 of pesticide / biocide distribution via natural carriers, aiming at products that are safe for workers and the environment, that exceed relevant technical and environmental limits, and that can be efficiently released into the environment over long periods of time. The objective of the present invention is to find new pesticide products, based on the use of natural or synthetic pesticides, using biodegradable polymers, that provide an efficient and long-lasting effect. An additional objective is to make available improved intermediate products suitable for the preparation of a variety of pesticide products with the above characteristics. Summary

[0010] New compositions are provided in which oily agronomic active ingredients are mixed with waxes and inorganic carriers within specific weight ranges. The compositions include an oily agronomic active ingredient and a wax in a weight ratio between 1.20:1 and 2.80:1; they also include an inorganic carrier in a weight ratio between 1.70:1 and 2.40:1 relative to the sum of the oily agronomic active ingredient and the wax. All these ingredients are uniformly dispersed in the composition. The compositions are perfectly suited for further processing into granules. Petition 870250090272, dated 03 / 10 / 2025, page 67 / 124 8 / 39 which, after administration to an agronomic surface, such as soil or plants, are distinguished by a sustained duration of action and resistance to leaching by environmental factors. Alternatively, the oily agronomic active ingredient and wax are mixed with a lipophilic solvent and a surfactant within specific weight ranges to obtain oily dispersions suitable for administration to an agronomic surface, such as soil or plants, distinguished by a sustained duration of action and excellent resistance to leaching by environmental factors. Detailed Description of the Invention

[0011] The present compositions are entirely homogeneous in their structure and are used to prepare correspondingly homogeneous products, in particular oily granules or dispersions, with reproducible activity levels and resistance to environmental leaching after application to agronomic surfaces. All compositions and products that are the subject of the invention are water-free; moreover, due to their homogeneous structure, they differ from multiphase or multistructured products, for example, coated cores, etc., which are therefore not part of the invention. Consequently, throughout this application, the terms mix, blended, mixing, mixtures indicate the formation of homogeneous systems. The term matrix used herein also indicates a homogeneous mixture of Petition 870250090272, dated 03 / 10 / 2025, page 68 / 124 9 / 39 its components.

[0012] In this description, the numerical ratios between the components are indicated by the sign “:”; all of them are weight ratios of the relevant components, in the respective order presented.

[0013] The invention is defined in this document by several ranges, defined by a lower and upper limit and by the expression “between / and” or “from / to”, which are equivalent and used interchangeably for the purposes of the invention. The aforementioned upper and lower limits, all values ​​between them, subranges and combinations thereof are part of the invention.

[0014] The term “oily” in the expression “oily agronomic active ingredient” indicates a lipophilic fluid product that is immiscible with aqueous solvents (for reference, distilled water at 20 °C) and is freely miscible with organic solvents (for reference: methylene chloride at 20 °C), having a kinematic viscosity of up to 100 mm2 / sec at 20 °C and ambient pressure, measured under standard conditions, compare with “Eur. Pharmacopoeia 10.0” (2.2.9 Capillary viscometer method).

[0015] The term “oily agronomic active ingredient” defines any agronomic active ingredient that is “oily” as defined above; however, the term also extends to agronomic active ingredients that are not Petition 870250090272, dated 03 / 10 / 2025, page 69 / 124 10 / 39 oily, but are dissolved or dispersed in carrier oils; the carrier oils are oily as defined above and remain so after the dissolution of the agronomic active ingredient. In all ratios described herein, the weight of the oily agronomic active ingredient is understood as a whole, thus also including the carrier oil, when present.

[0016] Examples of suitable carrier oils are vegetable oils, such as rapeseed oil, sunflower oil, soybean oil, olive oil and the like, modified vegetable oils, for example, alkoxylated sunflower or soybean oil, or synthetic oils. More generally, carrier oils may be chosen from the following classes of compounds, provided they are oily as defined above: (tri)glycerides such as, for example, technical mixtures of monoglycerides, diglycerides and triglycerides of C6 to C22 fatty acids, alkyl esters of fatty acids, for example, methyl or ethyl esters of vegetable oils, alkyl esters of fatty acids based on said C6 to C22 fatty acids, etc., linear C6 to C22 fatty acid esters with branched alcohols, in particular 2-ethylhexanol, C18 to C38 alkyl hydroxycarboxylic acid esters with linear or branched C6 to C22 fatty alcohols, linear or branched C6 to C22 fatty alcohols, in particular dioctyl malates, linear and / or branched fatty acid esters with. Petition 870250090272, dated 03 / 10 / 2025, p. 70 / 124 11 / 39 polyhydric alcohols (such as, for example, propylene glycol, dimerdiol or trimertriol) and / or Guerbet alcohols, triglycerides based on C6 to C10 fatty acids, liquid mixtures of monoglycerides / diglycerides / triglycerides based on C6 to C18 fatty acids, esters of C6 to C22 fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2 to C12 dicarboxylic acids with linear or branched alcohols with 1 to 22 carbon atoms or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, carbonates of C6 to C18 fatty alcohols C22 linear and branched, such as, for example, dicaprylyl carbonate (Cetiol™ CC), Guerbet carbonates based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, benzoic acid esters with C6 to C22 linear and / or branched alcohols (e.g., Finsolv™ TN),Linear or branched dialkyl ethers, symmetrical or asymmetrical, having 6 to 22 carbon atoms per alkyl group, such as, for example, dicaprylyl ether (Cetiol™ OE), ring-opening products of fatty acid esters epoxidized with polyols.

[0017] The wax used in the invention can be conveniently selected from currently available waxes. According to their origin, waxes are divided into three groups: natural waxes, chemically modified waxes, or Petition 870250090272, dated 03 / 10 / 2025, p. 71 / 124 12 / 39 synthetic; natural or chemically modified waxes are preferred; natural waxes are most preferred.

[0018] (i) Natural waxes include vegetable waxes (e.g., candelilla wax, carnauba wax, Japanese wax, esparto wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, ouricuri wax, montana wax, etc.), animal waxes (e.g., beeswax, shellac wax, spermaceti, lanolin or wool wax, uropygial grease, etc.) and mineral waxes (e.g., ceresin, ozokerite or earth wax, etc.); particularly preferred are myrtle wax, rice wax, candelilla wax, mimosa wax, carnauba wax, soy wax, beeswax; (ii) chemically modified waxes, including hard waxes (e.g., montana ester waxes, Sasol waxes, hydrogenated jojoba waxes, etc.); (iii) synthetic waxes, including polyalkylene waxes, polyalkylene glycol waxes (e.g., polyethylene glycol waxes), etc.

[0019] Generally, for the present invention, esters of a long-chain alcohol (preferably C12 to C32) with a fatty acid (preferably C12 to C32) that are solid at room temperature can be considered waxes.

[0020] For additional details on the concept of Petition 870250090272, dated 03 / 10 / 2025, page 72 / 124 13 / 39 waxes, it is possible to consult, for example, “Rompp Chemielexikon”, 10th edition, volume 6, 1999, Georg Thieme Verlag Stuttgart / New York, page 4.906, entry heading: “Wachse” [Waxes] and also the references cited therein, especially “Cosm. Toil.” 101, 49 (1986), and also “DGF Einheitsmethoden” [Standard Methods], M-Waxes and Wax Products department, 7th supplement 05 / 1999, “Stuttgart: Wissenschaftliche Verlagsgesellschaft”.

[0021] A typical aspect of the present compositions lies in the fact that the weight ratio between the oily agronomic active ingredient and the wax is between 1.20:1 and 2.80:1; preferably between 1.25:1 and 2.70:1; most preferably between 1.30:1 and 2.65:1. These ratios are reflected in any products obtained from the composition, in particular the granular products described herein. These ratios contribute to a correct balance of substances that is ideal from the point of view of sustained duration of action and resistance to leaching. The waxy substance, which is primarily responsible for the adhesion of the composition to the substrate to which it is applied, has the additional advantage of being selectable from entirely natural or naturally derived products, advantageously replacing any synthetic substances used in the prior art for the same purpose. Petition 870250090272, dated 03 / 10 / 2025, page 73 / 124 14 / 39

[0022] The active oily agronomic ingredient and the wax, considered as a whole, are referred to in this document as a “lipophilic matrix”: the attribute “lipophilic” derives from the presence of the wax and the active oily agronomic ingredient, both having a lipophilic character; the term “matrix” highlights a structural function for the co-presence of these ingredients in the composition.

[0023] According to a first main embodiment, the above compositions additionally contain an inorganic carrier, which contributes to their structural performance. The inorganic carrier can be chosen from those currently available. Examples of these are: silica-type materials, such as sand, broken walnut shells, clay materials, such as montmorillonite, kaolinite or other types of clay, diatomaceous earth, zeolite, chabazite, clinoptilolite, leonardite, andalusite, plastic clay, bentonite, calcium aluminate, feldspar, fused alumina, halloysite, mica, moler, mullite, zirconia, wollastonite, chamotte, perlite, carbon black and other low-density materials, such as granulated corn cobs and other organic derivatives; Talc, quartz, graphite, and many other inert materials with a variety of densities, and other useful and relatively insoluble nuclei include agricultural minerals such as sulfur, gypsum, and lime.

[0024] In the present compositions, the weight ratio of Petition 870250090272, dated 03 / 10 / 2025, page 74 / 124 The inorganic carrier to the lipophilic matrix (i.e., the sum of the weights of the oily agronomic active ingredient and the wax) is between 1.70:1 and 2.40:1. In more preferred embodiments, it is between 1.75:1 and 2.35:1; in more preferred embodiments, it is between 1.80:1 and 2.30:1. The inorganic carrier preferably has an average particle size between 30 and 85 μm. These ratios and sizes are reflected in any products obtained from the composition, in particular the granular products described in this document.

[0025] In particular, the combination of the lipophilic ingredient:wax ratio (from 1.20:1 to 2.80:1) with the inorganic carrier:lipophilic matrix ratio (from 1.70:1 to 2.40:1) yields a fairly fluid lipophilic matrix which is then mixed with a moderate excess of solid carrier, yielding a “soft product” endowed with sustained release properties and good adhesive properties once in contact with the plant or soil.

[0026] In general, any agronomic active ingredient can be used in the present invention. If they are “oily”, as defined in the present application, they can be used as such; otherwise, they can be dissolved or suspended in a carrier oil, thereby forming the oily agronomic active ingredient according to the invention.

[0027] In one embodiment, the agronomic active ingredient Petition 870250090272, dated 03 / 10 / 2025, page 75 / 124 16 / 39 oily is one or more essential oils, used alone or, optionally, dissolved or dispersed in carrier oils. Without limitation, examples of essential oils are: extracts of aromatic plants selected from the group consisting of extracts of Abies sibirica, Malpighia glabra, Achillea millefolium, Allium sativum, Medicago sativa, Aloe vera, Técnicamisia annua, Arnica montana, Ocimum basilicum, Betula pendula, Betula pubescens, Calendula officinalis, Matricaria chamomilla, Chamaemelum nobile, Cinnamomum verum, Centella asiatica, Chelidonium majus, Syzygium aromatium, Allium cepa, Equisetum arvense, Curcuma longa, Echinacea purpurea, Echinacea angustifolia, Eucalyptus globulus, Hypericum perforatum, Fucus vesiculosus, Glycine max, Glycyrrhiza glabra, Gentiana lutea, Lavandula angustifolia, seed of flax, Melilotus officinalis, Melissa officinalis, Punica granatum, Mentha piperita, Mentha spicata Vaccinium myrtillus, Origanum vulgaris, Orthosiphon stamineus,Urtica dioica, Olea europeae, Tabebuia impetiginosa, Plantago lanceolata, Hieracium pilosella, Pinus sibirica, Polypodium leucotoms, Citrus limon, Citrus sinensis, Citrus paradisi, Quassia amara, Rheum Thais, Rosa canina, Rosmarinus officinalis, Ruscus aculeatus, Salix alba, Salvia officinalis, Salvia rosmarinus, Sesamus indicum, Camelia sinensis, Tilia tomentosa, Thymus vulgaris, Arctostaphylos uva-ursi, Valeriana officinalis, Solidago virgaurea, Loranthus europaeus, Zingiber officinalis., Petition 870250090272, dated 03 / 10 / 2025, p. 76 / 124 17 / 39

[0028] In a preferred mode, the referred aromatic vegetal extract is selected from the group constituted by extracts of Mentha piperita, Mentha Spicata, Thymus vulgaris, Salvia officinalis, Rosmarinus officinalis, Sesamus indicum, Syzygium aromatium, Allium sativum, Citrus limon, Cinnamomum verum, Origanum vulgaris, separately or in a mixture.

[0029] Particularly preferred essential oils are: clove oil, neem oil, cinnamon oil, cedar oil, castor oil, geranium oil, lemongrass oil, peppermint oil, thyme oil, turmeric oil, wintergreen oil, rosemary oil, anise oil, cardamom oil, chamomile oil, coriander oil, cumin oil, dill oil, peppermint oil, parsley oil, lavender oil, basil oil, camphor oil, lemongrass oil, eucalyptus oil, fennel oil, ginger oil, grapefruit oil, lemon oil, tangerine oil, pine needle oil, pepper oil, rose oil, sweet orange oil, tangerine oil, tea tree oil, tea tree seed oil, cumin oil, garlic oil, peppermint oil, onion oil, mint oil, terpenes, azadirachtin, spinosyns, sesquiterpenes, oxygenated sesquiterpenes, phenylpropanoids.

[0030] In other embodiments, the agronomic active ingredient may be independently selected, for example, from one or more of the following insecticide classes, Petition 870250090272, dated 03 / 10 / 2025, page 77 / 124 18 / 39 fungicides, antimicrobials, nematicides, herbicides and semiochemical products. Mixtures of agronomic active ingredients belonging to the same class and / or different classes may also be used.

[0031] Insecticides can be selected, for example, from the classes of: acetylcholinesterase (AChE) inhibitors; sodium channel modulators; nicotinic acetylcholine receptor (nAChR) agonists; allosteric activators of the nicotinic acetylcholine receptor; chloride channel activators; juvenile hormone mimics; chordatonal organ TRPV channel modulators; mite growth inhibitors; microbial insecticidal proteins; mitochondrial ATP synthase inhibitors; oxidative phosphorylation uncouplers; nicotinic acetylcholine receptor (nAChR) channel blockers; chitin biosynthesis inhibitors; molt disruptors; ecdysone receptor agonists; octopamine receptor agonists; inhibitors of mitochondrial complex I, II or III electron transport; Voltage-dependent sodium channel blockers; acetyl CoA carboxylase inhibitors; ryanodine receptor modulators; chordatonal organ modulators;Plant toxins and their derivatives.

[0032] Preferred insecticides are selected from among pyrethroids and neonicotinoids, such as bifenthrin, deltamethrin, permethrin, sumitrin, tetramethrin, transfluthrin, Petition 870250090272, dated 03 / 10 / 2025, page 78 / 124 19 / 39 acetamiprid, clothianidin, cycloxapride, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam.

[0033] Fungicides can be selected, for example, from the classes of: respiration inhibitors; sterol biosynthesis inhibitors; nucleic acid synthesis inhibitors; cell division and cytoskeleton inhibitors; amino acid and protein synthesis inhibitors; signal transduction inhibitors; protein inhibitors; inhibitors with multi-site action; cell wall synthesis inhibitors; plant defense inducers.

[0034] The preferred fungicides are chosen from azoxystrobin, boscalid, carboxin, fenfuram, azaconazole, cyproconazole, prothioconazole, difenoconazole, diniconazole, diniconazole-epoxiconazole, fenbuconazole, tebuconazole, imazalil, prochloraz, triflumizole, fenarimol, pyrifenox, triporin, valifenalate.

[0035] Antimicrobials can be selected, for example, from the class of antimicrobial peptides. Antimicrobial peptides are a class of small peptides widely found in nature and are an important part of the innate immune system of different organisms and have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses.

[0036] Suitable antimicrobial peptides are described on the Norine platform (see “Norine: update of the Petition 870250090272, dated 03 / 10 / 2025, page 79 / 124 20 / 39 nonribosomal peptide resource”. Areski Flissi, Emma Ricart, Clémentine Campart, Mickael Chevalier, Yoann Dufresne, Juraj Michalik, Philippe Jacques, Christophe Flahaut, Frédéric Lisacek, Valérie Leclère e Maude Pupin “ Nucleic Acids Research ”, novembro de 2019, gkz1000, https: / / doi.org / 10.1093 / nar / gkz1000), e representados, por exemplo, pelas famílias A42867, A51568, A54145, A83850, ACV, toxina AM, antibiótico BT, antibiótico dependente de cálcio toxina HC Kurstakin LP237 M43 MM OA7653 Orfamida PF1022 aciculitin actinoidin actinomycin aeruginosin alamethicin amphibactin amphisin ampullosporin anabaenopeptilida anabaenopeptin andramida anguibactin antiamebine antidor apicidin apramida aquacheline arylomycin atroviridine aureobasidin aurilide avoparcin axinastatin axineline nitrogêniobactin bacilibactin bacilisin bacitracin balhimycin bananamida barangamida beauvericina beauverolida bergofungina beta-lactamico boletusina bottromycin brevianamida lipopeptídeoCa+ dependent calypeltin callinormin capreomycin carmabin cepaciachelin cephaloid keratospongamide cereulide cervinine chlamidocin chloropolysporin chrysobactin chrysospermine coelichelin coronatine corrugatin cortiamide cupolamide depsipeptide cyclic cyanopeptoline cyclochlorotin cyclocinamide cyclolinopeptide cyclolitide cyclonellin cyclosporine disamide cyclotheonamide daptomycin decaplanin destruxin didemnin discotecabahamine discodermin dolastatin disamide edeine emerimycin empedopeptin enduracidin Petition 870250090272, dated 03 / 10 / 2025, page 80 / 124 21 / 39 enniatin ennopeptin enterobactin entolysin eremomycin eurypamide feglimycin, fengycin ferintoic acid phoroxymitin friulimycin fuscopeptin galacardin geodiamolide globomycin glycopeptide gramicidin gratisine guineamide gimnangiamide halicylinderramide haligramide halipeptin harzianine helvecardine hemiasterlin heptaibin heptarizines hymenamide hymenistatin hypomurocin isaridina isariin iturin jagaricin jaspamide kahalalide foreman kempopeptin kempopeptin kempopeptin keramamide konbamide koshikamide kulokainalide kulolide kulomo opunalidalargamide leupeptin longibraquine lysobactin majusculamide malformin marinobactin microcystin microgynin micromide microsclerodermin microspinosamide miraziridine montanastatin mozamide mycobacillin nagahamide nazumamide neosiphoniamolide neoviridogriseine nocardicin nodulapeptin nodularin nrp siderophore obianamide onchidin orbiculamide oriamide orienticin ornibactin oscillamide, others (unclassified families,such as disgocidin Chondrochlor Microsclerodermin cytochalasin E lidicamycin Mixoprincomida-c506 marinopyrrole E diaphorin cytochalasin K Prezeamine Aeruginosin 98-C methylpendolmycin Microsclerodermin M thailandamide A triprostatin A Xenortide A neolymphostinol B Chivosazol Mixocromide S1 chloramphenicol marinopyrrole Czeamine chaetoglobosins Petition 870250090272, dated 03 / 10 / 2025, page 81 / 124 22 / 39 C Nostopicina distamicina frontalamide B fumitremorgina B marinopirrol D martiapeptídeo A Xenortide marinopirrol B Rabdopeptídeo 3 4-desoxigaduso neolinfosta B caliculin A caliculinamida A thailandamide B demetoxifumitremorgin C Rabdopeptídeo 4 Notoamida A), other lipopeptídeo (tal como hectoclorina Equinocandina B bacilomicina D fusaricidina B Xenolindicina A surfactina xantolysin C alpha-lipomycin Arilomycin Talassospiramide A xantolysin B) palidina papuamide paracelsina peptaibolin peptaivirina pertamida petrosifungina phakelistatina foriospongina tripeptídeo fosfinotricina plusbacina polidiscamide polimixina pristinamicina I pseudocycline pseudoteonamida pupukeamida putisolvina yoverdine pyrrolobenzodiazepine quinomycin ramoplanina cytalidamida serrawettina somamida estilboflavina estilopeptídeo estilostatina surfactin syringafactina syringomycin, syringopeptina, tentoxin, teonegramida, teonelamida,teonelapeptolide theopalauamide toramide tolaasin trichobrachina trichorzine trichotoxin triostine tripropeptin tuberactinomycin thyrocidin uridylpeptide valinomycin vancomycin vibriobactin virginiamycin viscosine waiakeamide wainunuamide zervamycin.

[0037] In one embodiment, the antimicrobial peptides are beauvericins; cyclic depsipeptides, aureobasidines, cyclosporines.

[0038] Nematicides are chemical agents used to control parasitic worms, such as roundworms and pinworms. Petition 870250090272, dated 03 / 10 / 2025, page 82 / 124 23 / 39 In a preferred embodiment, the nematicides are selected from Oxamyl, Fluensulfone, Fluopyram, and Etoprop. In another preferred embodiment, the nematicides are clove oil and eugenol.

[0039] Herbicides can be selected, for example, from the classes of: lipid biosynthesis inhibitors; acetolactate synthase inhibitors; photosynthesis inhibitors; protoporphyrinogen-IX oxidase inhibitors; bleaching herbicides; enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); glutamine synthetase inhibitors; 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); mitosis inhibitors; very long-chain fatty acid synthesis inhibitors (VLCFA inhibitors); cellulose biosynthesis inhibitors; uncoupling herbicides; auxin herbicides; auxin transport inhibitors.

[0040] Preferred herbicides may be selected from protoporphyrinogen-IX oxidase inhibitors, enolpyruvyl shikimate 3-phosphate synthase inhibitors, mitosis inhibitors and inhibitors of very long chain fatty acid synthesis (VLCFA inhibitors).

[0041] Semiochemical products can be selected, for example, from the classes of pheromones and kairomones. They can be selected from acyclic terpenes, such as C19 to C21 (Z,Z,Z)-3,6,9 triene hydrocarbon, C19 to C21 (Z,Z)-6,9 diene hydrocarbon, their alcohols and Petition 870250090272, dated 03 / 10 / 2025, page 83 / 124 24 / 39 esters, small ring terpenes such as limonene, sabinene, alpha terpineol, large ring terpenes such as periplanone B,C,D,J, fused ring terpenes such as camphor, borneol, 3-carene, nepetaloctol, heterocyclic terpenes such as perylene, rose oxide.Preferably, they are selected from L-carvone, citral, (E,Z)7,9-dodecadien-1-yl acetate, ethyl formate, (E,Z)2,4-ethyl decadienoate (pear ester), (Z,Z,E)-7,11,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, cis-jasmone, methyl eugenol, methyl jasmonate, (E,Z)2,13-octadecadien-1-ol, (E,Z)-2,13-octadecadien-1-ol acetate, (E,Z)-3,13-octadecadien-1-ol, ©-1-octen-3-ol, pentatermanone, (E,Z,Z)-3,8,11-tetradecatrienyl, acetate (Z,E)-9,12-tetradecadien-1-yl, (Z)-7-tetradecen-2-one, (Z)-9-tetradecen-1-yl acetate, (Z)-11-tetradecenal, (Z)-11-tetradecen1-ol, Chenopodium ambrosiodes extract, neem oil, quillaja extract or mixtures thereof.

[0042] The present compositions are useful for the production of improved granular products, applicable in the agronomic field, distinguished by excellent properties of sustained duration of action and good resistance to environmental agents, in particular leaching by means of environmental agents such as rain (rain resistance), wind, etc.

[0043] A further objective of the invention is a process for producing the granular compositions and products described. Petition 870250090272, dated 03 / 10 / 2025, page 84 / 124 25 / 39 previously. The process is generally distinguished by the following steps: (a) mix the oily agronomic active ingredient with the wax, at a temperature higher than the melting point of the wax, followed alternatively by: (b1) cool the product of step (a) to a temperature below the melting point of the wax and mix the resulting product with the inorganic carrier, or (b2) mix the product of step (a) with the inorganic carrier and cool the resulting product to a temperature below the melting point of the wax.

[0044] The resulting product can be further treated by conventional methods, for example, by extrusion, to obtain a uniform granular formulation.

[0045] In this process, the weight ratio of oily agronomic active ingredient to wax is between 1.20:1 and 2.80:1, and the weight ratio of inorganic carrier to lipophilic matrix [i.e., oily agronomic active ingredient + wax] is between 1.70:1 and 2.40:1. The preferred subranges for these ratios in the present process are those described above in relation to the composition.

[0046] All mixing steps are carried out until a homogeneous mixture of all components is obtained. Mixing is preferably carried out by means of agitation. Petition 870250090272, dated 03 / 10 / 2025, page 85 / 124 26 / 39

[0047] In step (a), the mixing is preferably carried out at a temperature at least 10 °C higher than the melting temperature of the wax.

[0048] The inorganic carrier preferably has an average particle size between 30 and 85 μm.

[0049] The mixing of the inorganic carrier with the lipophilic matrix can be conveniently carried out at room temperature and in conventional mixers, obtaining a homogeneous mixture.

[0050] The compositions presented, as obtained or obtainable through the aforementioned process, typically have a solid or semi-solid consistency; from this product, uniformly structured granules can be obtained by conventional means, such as extrusion through a small mesh size, for example, with a mesh size between 1 and 3 mm, for example, 2 mm. The granular product formed is suitable for direct application to the soil and / or plants and does not require dissolution or dispersion in an aqueous medium for subsequent irrigation. The lipophilic and unctuous character of the product ensures strong adherence to the soil or plant, resisting leaching by water and dispersion by wind, protecting the active ingredient from degradation and ensuring its sustained release over time.

[0051] An additional objective of the invention is the products Petition 870250090272, dated 03 / 10 / 2025, page 86 / 124 27 / 39 agronomic granules obtained from the composition described above. These products are distinguished by high specific activity (i.e., the ratio between the activity found in the active ingredient and the amount administered), enhanced properties of prolonged duration of action, and good resistance to environmental agents such as leaching by rainwater (rain resistance), wind, etc. In particular, the granules are especially effective in high specific activity and prolonged duration of action.

[0052] The invention also includes a method of application, i.e., administration, of the granular agronomic formulation described above to a substrate. Said application is typically carried out by dispersing the corresponding granular product in its own solid form, i.e., not carried by liquids. The application substrate is typically soil or a plant or plant parts in need thereof, with the advantage of the product's adhesiveness caused by its lipophilic and unctuous character. The plant parts to which the granular product is applicable may be selected, without limitation, from: leaves, bark, fruits, flowers, seeds or roots of plants and crops; specific examples thereof are cereals, beans, peas, fruit trees, nuts, chestnuts, almonds, leafy vegetables, fruit vegetables, root vegetables, processing crops, cucurbit plants, Petition 870250090272, dated 03 / 10 / 2025, page 87 / 124 28 / 39 pasture plants, grasses, perfume crops, ornamental plants, timber, etc.

[0053] According to a second main embodiment of the present invention, a composition is provided in which the oily agronomic active ingredient and the wax are homogeneously mixed in a mutual weight ratio of between 1.20:1 and 3.80:1 (preferably between 1.50:1 and 3.60:1; more preferably between 1.80:1 and 3.40:1) and are not associated with the inorganic carrier. This composition, also defined herein as a “lipophilic matrix”, is further mixed with a lipophilic solvent and a surfactant as additional ingredients. In particular: i) the lipophilic solvent is added in a weight ratio to the oily agronomic active ingredient of between 1:1 and 3:1 (preferably between 1.2:1 and 2.7:1; more preferably between 1.3:1 and 2.4:1) and ii) the surfactant is added in a weight ratio to the oily agronomic active ingredient of between 0.20:1 and 0.90:1 (preferably between 0.24:1 and 0.80:1; more preferably between 0.28:1 and 0.70:1).

[0054] The resulting product (oily dispersion) is suitable for application to agronomic surfaces, such as soil or plants, and is distinguished by a prolonged duration of action and excellent resistance to leaching by environmental factors. Petition 870250090272, dated 03 / 10 / 2025, page 88 / 124 29 / 39

[0055] In these compositions, the lipophilic solvent is additional to and different from the oily agronomic active ingredient and any components thereof: subject to this arrangement, the lipophilic solvent may be freely chosen, without criticality, from among any currently available lipophilic solvents. Consequently, suitable lipophilic solvents may be chosen, without limiting the invention to one or more of the following: - Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of linear C6 to C22 fatty acids with linear or branched C6 to C22 fatty alcohols, or esters of branched C6 to C13 carboxylic acids with linear or branched C6 to C22 fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, palmitate stearyl, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, Petition 870250090272, dated 03 / 10 / 2025, page 89 / 124 30 / 39 oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucil myristate, erucil palmitate, erucil stearate, erucil isostearate, erucil oleate, erucil behenate and erucil erucate. - esters of linear C6 to C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of C18 to C38 alkylhydroxycarboxylic acids with linear or branched C6 to C22 fatty alcohols, in particular dioctyl malate, esters of linear and / or branched fatty acids with polyhydric alcohols (such as, for example, propylene glycol, dimerdiol or trimertriol and / or Guerbet alcohols), triglycerides based on C6 to C10 fatty acids, liquid mixtures of monoglycerides / diglycerides / triglycerides based on C6 to C18 fatty acids, esters of C6 to C22 fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of dicarboxylic acids C2 to C12 linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes,linear and branched C6 to C22 fatty alcohol carbonates, such as, for example, Petition 870250090272, dated 03 / 10 / 2025, pp. 90 / 124 31 / 39 For example, dicaprylyl carbonate (Cetiol® CC), Guerbet carbonates, based on fatty alcohols with 6 to 18, preferably 8 to 10, carbon atoms, benzoic acid esters with linear and / or branched C6 to C22 alcohols, symmetrical or asymmetrical linear or branched dialkyl ethers having 6 to 22 carbon atoms per alkyl group, such as, for example, dicaprylyl ether, ring-opening products of epoxidized fatty acid esters with polyols.

[0056] Within the context of the present invention, preferred solvents are Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of linear C6 to C22 fatty acids with linear or branched C6 to C22 fatty alcohols, or esters of branched C6 to C13 carboxylic acids with linear or branched C6 to C22 fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearateisostearyl oleate, behenate, Petition 870250090272, dated 03 / 10 / 2025, pp. 91 / 124 32 / 39 of isostearyl, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucil myristate, erucil palmitate, erucil stearate, erucil isostearate, erucil oleate, erucil behenate and erucil erucate.

[0057] The other components of the composition according to the second principal embodiment, namely, the oily components of the agronomically active ingredient (agronomically active ingredient and, when present, the oil) and the wax, may be freely chosen from within the same groups of compounds, among the same specific compounds, to the same degree of preference and associability, as exemplified and claimed in relation to the first principal embodiment.

[0058] Consequently, the second principal embodiment can be described as a composition comprising, in homogeneous mixture: an oily agronomic active ingredient and a wax, which have a weight ratio of oily agronomic active ingredient to wax between 1.20:1 and 3.80:1 (preferably between 1.50:1 and 3.60:1; more preferably between 1.80:1 and 3.40:1), a lipophilic solvent and a wax.

[0059] In particular, in the said composition, the solvent Petition 870250090272, dated 03 / 10 / 2025, pp. 92 / 124 The lipophilic 33 / 39 is present in a weight ratio to the oily agronomic active ingredient of between 1:1 and 3:1 (preferably between 1.2:1 and 2.7:1; more preferably between 1.3:1 and 2.4:1), and the surfactant is present in a weight ratio to the oily agronomic active ingredient of between 0.20:1 and 0.90:1 (preferably between 0.24:1 and 0.80:1; more preferably between 0.28:1 and 0.70:1).

[0060] The invention is now described by the following non-limiting examples. EXPERIMENTAL Example 1 - Clove Oil Granules

[0061] 2 kg of clove oil [oily agronomic active ingredient] were heated to 50 °C in the presence of paraffin (1.5 kg). Once a clear solution was obtained, the mixture was allowed to cool to room temperature and added to 8 kg of bentonite under stirring in a professional mixer. The paste was then extruded in a pilot extruder using a 2 mm diameter mesh. Example 2 - Oily Dispersion of Pyrethrum Extract

[0062] 1 kg of pyrethrum extract (50%) [oily agronomic active ingredient] is added to 2 kg of rapeseed oil [carrier oil]. The mixture was heated to 50 °C in the presence of paraffin (1.5 kg). Once a clear solution was obtained, the mixture was allowed to cool to room temperature. In this Petition 870250090272, dated 03 / 10 / 2025, pp. 93 / 124 At point 34 / 39, 4.5 kg of soy methyl ester [lipophilic solvent] and 1 kg of the appropriate alkyl sulfate surfactant were added under stirring. Example 3 - Difenoconazole Oil Dispersion

[0063] 500 g of difenoconazole (98%) [agronomically active ingredient] are added to 2 kg of tangerine oil [carrier oil]. The mixture is heated to 70 °C in the presence of beeswax (1 kg). Once a clear solution is obtained, the mixture is allowed to cool to room temperature. At this point, 4.8 kg of sunflower oil methyl esters [lipophilic solvent] and 1.1 kg of amino acid surfactant are added under stirring. Example 4 - Clove and Mustard Oil Granules

[0064] 1.2 kg of clove oil [agronomically active ingredient] and 1.2 kg of mustard oil [agronomically active ingredient] were heated to 50 °C in the presence of paraffin (1.8 kg). Once a clear solution was obtained, the mixture was allowed to cool to room temperature and added to 8 kg of mullite under stirring in a professional mixer. The paste was then extruded in a pilot extruder using a 2 mm diameter mesh. Example 5 - Aspocracin Oil Dispersion

[0065] 50 mg of Aspocracin [agronomically active ingredient] are added to 200 mg of tangerine oil [agronomically active ingredient] and 60 mg of carvacrol [ingredient] Petition 870250090272, dated 03 / 10 / 2025, pp. 94 / 124 35 / 39 agronomically active]. The mixture was heated to 70 °C in the presence of beeswax (100 mg). Once a clear solution was obtained, the mixture was allowed to cool to room temperature. At this point, 390 mg of propylene glycol methyl esters [lipophilic solvent] and 200 mg of suitable non-ionic copolymer block surfactants were added with stirring. Example 6 - Efficacy Trials: Nematicidal Activity in Tomato and Cucumber (Field Trials) 6.1 - Tomato

[0066] Plots of 25 m2 of tomato seedlings (BBCH 12 to 14) were installed to evaluate the effectiveness of the formulated products described in examples 1 and 4 against nematodes. A commercial reference product against nematodes was used as a control.

[0067] The test design is shown in Table 1: Treatment Index (kg of active ingredient / ha) Application Date Untreated - - Commercial Reference 8.6 kg / ha 1 day after transplanting Clove oil granules 1.2 kg / ha 1 day after transplanting Clove and mustard oil granules 1.2 kg / ha 1 day after transplanting Table 1.

[0068] After 72 days (BBCH 65-67), the trial was analyzed in terms of effectiveness compared to the control.

[0069] The results are presented in Table 2: Treatment % Effectiveness Not treated 0 Petition 870250090272, dated 03 / 10 / 2025, pp. 95 / 124 36 / 39 Commercial reference 80 Clove oil granules 78 Clove and mustard oil granules 70 Table 2. 6.2 - Cucumber

[0070] Plots of 25 m2 of cucumber seedlings (BBCH 12 to 14) were set up to evaluate the effectiveness of the formulated products described in examples 1 and 4 against nematodes. A commercial reference product against nematodes was used as a control.

[0071] The test design is shown in Table 3: Treatment Index (kg of active ingredient / ha) Application Date Untreated - - Commercial Reference 8.6 kg / ha 1 day after transplanting Clove oil granules 1.2 kg / ha 1 day after transplanting Clove and mustard oil granules 1.2 kg / ha 1 day after transplanting Table 3.

[0072] After 43 days (BBCH 69-71), the trial was analyzed in terms of efficacy relative to the control. The results are reported in Table 4: Treatment % Effectiveness Not treated 0 Commercial Reference 93 Clove oil granules 93 Clove and mustard oil granules 95 Table 4.

[0073] The results obtained in Tables 4 and 2 show, for the formulations according to the invention, excellent duration of action and therefore release properties. Petition 870250090272, dated 03 / 10 / 2025, pp. 96 / 124 37 / 39 prolonged duration of the active ingredient over time, of the same order or even superior to commercial reference products, with the advantage of a composition based on natural and environmentally friendly wax. Example 7 - Rain Resistance of In Vitro Products

[0074] The products from examples 2, 3 and 5 were tested for resistance to rain.

[0075] A section of Parafilm® thermoplastic film (10 x 30 cm) is treated by spraying with 2 mL of a solution obtained by diluting the product in water to 50% w / v.

[0076] The thermoplastic film section is allowed to dry at room temperature and the entire surface is then washed with 12 mL of water using a standard spray system with a 1 mm nozzle. After washing, the thermoplastic film section is dried and treated with 98% ethanol. The collected solution is analyzed for residual product content after washing by HPLC-MS.

[0077] The results are highlighted in Table 5: Amount of active ingredient (mg) Residual amount of active ingredient after washing (%) Example 2 50 70 Example 3 50 75 Example 5 50 77 Table 5. Example 8 - Rain Resistance of Greenhouse-Grown Products

[0078] Plots of 5 m2 of seedlings were installed. Petition 870250090272, dated 03 / 10 / 2025, page 97 / 124 38 / 39 tomato (BBCH 13 to 29) to assess the residual properties of the products described in examples 2 and 3 on the sheet.

[0079] As a control, the same unformulated products are used at the same dose.

[0080] The test design is shown in Table 6: Active ingredient content (%) Number of applications Number of replicates Dose Example 2 5 1 3 2 L / ha Example 3 5 1 3 2 L / ha Pyrethrum extract Not formulated 5 1 3 2 L / ha Difenoconazole not formulated 5 1 3 2 L / ha Table 6.

[0081] The different products containing the respective active ingredient were applied at a dosage of 2 L / ha by diluting the product in enough water to thoroughly wet the crop, but limiting the dripping (minimum 200 L / ha).

[0082] After 4 hours, the seedlings are sprayed with water for 5 minutes to simulate a rainfall of 40 to 50 mm. The leaves are left to dry. After drying, the leaves from each test are collected and analyzed to quantify the residual active ingredient.

[0083] The results are presented in Table 7: Active ingredient content (%) Residual amount of active ingredient after washing (%) Example 2 5 68 Example 3 5 74 Pyrethrum extract Not formulated 5 35 Difenoconazole not formulated 5 38 Table 7. Petition 870250090272, dated 03 / 10 / 2025, pp. 98 / 124 39 / 39

[0084] The results obtained in tables 5 and 7 show, for the formulations according to the invention, excellent rain resistance properties, of the same order or even superior to commercial reference products, with the advantage of a composition based on natural and environmentally friendly wax. Petition 870250090272, dated 03 / 10 / 2025, pp. 99 / 124

Claims

1 / 11 CLAIMS 1. A granular composition, characterized in that it comprises, in a homogeneous mixture: an inorganic carrier, an oily agronomic active ingredient and a wax, which has a weight ratio of oily agronomic active ingredient to wax between 1.20:1 and 2.80:1, and a weight ratio of inorganic carrier to [oily agronomic active ingredient + wax] between 1.70:1 and 2.40:1, wherein the term “oily agronomic active ingredient” defines the active ingredient as such or a solution or dispersion thereof in a carrier oil, and the term “oily” defines a lipophilic fluid product immiscible with water and freely miscible with methylene chloride, which has a kinematic viscosity of up to 100 mm² / sec at 20 °C and ambient pressure.

2. Composition, according to claim 1, characterized in that the weight ratio of oily agronomic active ingredient to wax is between 1.25:1 and 2.70:

1.

3. Composition according to claim 1, characterized in that the weight ratio of oily agronomic active ingredient to wax is between 1.30:1 and 2.65:

1.

4. Composition, according to claims 1 to 3, characterized in that the oily agronomic active ingredient includes one or more essential oils.

5. Composition, according to claim 4, characterized in that the essential oils are selected from Petition 870250090272, dated 03 / 10 / 2025, page.111 / 124 2 / 11 clove oil, neem oil, cinnamon oil, cedar oil, castor oil, geranium oil, lemongrass oil, peppermint oil, thyme oil, turmeric oil, wintergreen oil, rosemary oil, anise oil, cardamom oil, chamomile oil, coriander oil, cumin oil, dill oil, peppermint oil, parsley oil, lavender oil, basil oil, camphor oil, lemongrass oil, eucalyptus oil, fennel oil, ginger oil, grapefruit oil, lemon oil, tangerine oil, pine needle oil, pepper oil, rose oil, sweet orange oil, tangerine oil, tea tree oil, tea tree seed oil, cumin oil, garlic oil, peppermint oil, onion oil, mint oil, terpenes, azadirachtin, spinosyns, sesquiterpenes, oxygenated sesquiterpenes, phenylpropanoids.

6. Composition, according to claims 1 to 5, characterized in that the agronomic active ingredient includes one or more substances belonging to the classes of: insecticides, fungicides, antimicrobials, nematicides, herbicides, semiochemical products.

7. Composition according to claim 6, characterized in that: (a) the insecticides are selected from the classes of: acetylcholinesterase (AChE) inhibitors; sodium channel modulators; nicotinic acetylcholine receptor (nAChR) agonists; allosteric activators of the nicotinic acetylcholine receptor; chloride channel activators; juvenile hormone mimics; chordatonal organ TRPV channel modulators; mite growth inhibitors; microbial insecticidal proteins; mitochondrial ATP synthase inhibitors; oxidative phosphorylation uncouplers; nicotinic acetylcholine receptor (nAChR) channel blockers; inhibitors of chitin biosynthesis; molting disruptors; ecdysone receptor agonists; octopamine receptor agonists; inhibitors of mitochondrial complex I, II or III electron transport; voltage-dependent sodium channel blockers;(a) Acetyl CoA carboxylase inhibitors; ryanodine receptor modulators; chordatonal organ modulators; plant toxins and their derivatives; (b) fungicides are selected from the classes of: respiration inhibitors; sterol biosynthesis inhibitors; nucleic acid synthesis inhibitors; cell division and cytoskeleton inhibitors; amino acid and protein synthesis inhibitors; signal transduction inhibitors; protein inhibitors; multi-site inhibitors; cell wall synthesis inhibitors; plant defense inducers; (c) antimicrobials are antimicrobial peptides; (d) herbicides are selected from the classes of: lipid biosynthesis inhibitors; acetolactate synthase inhibitors; photosynthesis inhibitors; inhibitors. Petition 870250090272, dated 03 / 10 / 2025, page. 113 / 124 4 / 11 of protoporphyrinogen-IX oxidase; bleaching herbicides; enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors);(e) Nematicides are selected from Oxamyl, Fluensulfone, Fluopyram, Etoprop, clove oil and eugenol. (f) Semiochemicals are selected from the classes of pheromones and kairomones.

8. Composition, according to claims 1 to 7, characterized in that the wax is selected from one or more of: (i) Natural waxes, such as myrtle wax, rice wax, candelilla wax, mimosa wax, carnauba wax, soy wax, Japanese wax, esparto wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, ouricuri wax, montana wax; animal waxes, such as beeswax, shellac wax, spermaceti, lanolin or wool wax, uropygial grease; mineral waxes, such as ceresin, ozokerite or earth wax; (ii) chemically modified waxes, such as montana ester waxes, Sasol waxes, hydrogenated jojoba waxes; Petition 870250090272, dated 03 / 10 / 2025, p. 114 / 124 5 / 11 (iii) synthetic waxes, such as polyalkylene waxes, polyalkylene glycol waxes.

9. Composition according to claims 1 to 8, characterized in that the inorganic carrier has an average particle size between 30 and 85 µm.

10. Composition, according to claims 1 to 9, characterized in that the inorganic carrier is selected from: silica-type materials, such as sand, broken walnut shells, clayey materials, such as montmorillonite, kaolinite or other types of clay, diatomaceous earth, zeolite, chabazite, clinoptilolite, leonardite, andalusite, plastic clay, bentonite, calcium aluminate, feldspar, fused alumina, halloysite, mica, moler, mullite, zirconia, wollastonite, chamotte, perlite, carbon black, granulated corn cobs, talc, quartz, graphite, sulfur, gypsum, lime.

11. Composition, according to claims 1 to 10, characterized in that the weight ratio of inorganic carrier to [oily agronomic active ingredient + wax] is between 1.75:1 and 2.35:1 or between 1.80:1 and 2.30:

1.

12. Use of the composition, as defined in claims 1 to 11, characterized in that it is for application to a plant and / or soil in an agronomic treatment method.

13. Procedure for preparing the composition, as defined in Petition 870250090272, dated 03 / 10 / 2025, page 13.115 / 124 6 / 11 in claims 1 to 11, characterized in that it comprises the steps of: (a) mixing the oily agronomic active ingredient with the wax, at a temperature higher than the melting point of the wax, followed alternatively by: (b1) cooling the product of step (a) to a temperature below the melting point of the wax, mixing the resulting product with the inorganic carrier and further processing the resulting product to obtain granules; or (b2) mixing the product of step (a) with the inorganic carrier and cooling the resulting product to a temperature below the melting point of the wax and further processing the resulting product to obtain granules; wherein the weight ratio of oily agronomic active ingredient to wax is between 1.20:1 and 2.80:1, and the weight ratio of inorganic carrier to [oily agronomic active ingredient + wax] is between 1.70:1 and 2.40:

1.

14. Product, characterized in that it is obtained through the process as defined in claim 13.

15. Oily dispersion, characterized by the fact that it comprises, in a homogeneous mixture: an oily agronomic active ingredient and a wax, in a weight ratio of oily agronomic active ingredient to wax between 1.20:1 and 3.80:1, a lipophilic solvent additional to and different from the oily agronomic active ingredient and a surfactant, wherein the term oily defines a lipophilic fluid product immiscible with water and freely miscible with methylene chloride, which has a kinematic viscosity of up to 100 mm² / sec at 20 °C and ambient pressure.

16. Oily dispersion, according to claim 15, characterized in that the lipophilic solvent is in a weight ratio to the oily agronomic active ingredient of between 1:1 and 3:1, and the surfactant is in a weight ratio to the oily agronomic active ingredient of between 0.20:1 and 0.90:

1.

17. Oily dispersion, according to claims 15 and 16, characterized in that the oily agronomic active ingredient includes one or more essential oils.

18. Oily dispersion, according to claim 17, characterized in that the essential oils are selected from clove oil, neem oil, cinnamon oil, cedar oil, castor oil, geranium oil, lemongrass oil, peppermint oil, thyme oil, turmeric oil, wintergreen oil, rosemary oil, anise oil, cardamom oil, chamomile oil, coriander oil, cumin oil, dill oil, peppermint oil, parsley oil, lavender oil, basil oil, camphor oil, lemongrass oil, eucalyptus oil, fennel oil, ginger oil, grapefruit oil, lemon oil, mandarin oil, Petition 870250090272, dated 03 / 10 / 2025, p.117 / 124 8 / 11 pine needle oil, pepper oil, rose oil, sweet orange oil, tangerine oil, tea tree oil, tea tree seed oil, cumin oil, garlic oil, peppermint oil, onion oil, spearmint oil, terpenes, azadirachtin, spinosyns, sesquiterpenes, oxygenated sesquiterpenes, phenylpropanoids.

19. Oily dispersion, according to claims 15 to 18, characterized in that the agronomic active ingredient includes one or more substances belonging to the classes of: insecticides, fungicides, antimicrobials, nematicides, herbicides, semiochemical products.

20. Oily dispersion according to claim 19, characterized in that: (a) the insecticides are selected from the classes of: acetylcholinesterase (AChE) inhibitors; sodium channel modulators; nicotinic acetylcholine receptor (nAChR) agonists; allosteric activators of the nicotinic acetylcholine receptor; chloride channel activators; juvenile hormone mimics; chordatonal organ TRPV channel modulators; mite growth inhibitors; microbial insecticidal proteins; mitochondrial ATP synthase inhibitors; oxidative phosphorylation uncouplers; nicotinic acetylcholine receptor (nAChR) channel blockers; chitin biosynthesis inhibitors; molt disruptors; ecdysone receptor agonists; agonists of the receptor of Petition 870250090272, of 03 / 10 / 2025, page 118 / 124 9 / 11 octopamine; Inhibitors of electron transport of mitochondrial complex I, II or III; voltage-dependent sodium channel blockers;(a) Acetyl CoA carboxylase inhibitors; ryanodine receptor modulators; chordatonal organ modulators; plant toxins and their derivatives; (b) Fungicides are selected from the classes of: respiration inhibitors; sterol biosynthesis inhibitors; nucleic acid synthesis inhibitors; cell division and cytoskeleton inhibitors; amino acid and protein synthesis inhibitors; signal transduction inhibitors; protein inhibitors; multi-site inhibitors; cell wall synthesis inhibitors; plant defense inducers; (c) Antimicrobials are antimicrobial peptides; (d) Herbicides are selected from the classes of: lipid biosynthesis inhibitors; acetolactate synthase inhibitors; photosynthesis inhibitors; protoporphyrinogen-IX oxidase inhibitors; bleaching herbicides; enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); glutamine synthetase inhibitors;7,8-dihydropteroate synthase inhibitors (DHP inhibitors); mitosis inhibitors; inhibitors of very long-chain fatty acid synthesis (VLCFA inhibitors); cellulose biosynthesis inhibitors; uncoupling herbicides; auxin herbicides; auxin transport inhibitors; Petition 870250090272, dated 03 / 10 / 2025, pp. 119 / 124 10 / 11 (e) nematicides are selected from Oxamyl, Fluensulfone, Fluopyram, Etoprop, clove oil and eugenol; (f) semiochemicals are selected from the pheromone and kairomone classes.

21. Oily dispersion, according to claims 15 to 20, characterized in that the wax is selected from one or more of: (i) natural waxes, such as myrtle wax, rice wax, candelilla wax, mimosa wax, carnauba wax, soy wax, Japanese wax, esparto wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, ouricuri wax, montana wax; animal waxes, such as beeswax, shellac wax, spermaceti, lanolin or wool wax, uropygial grease; mineral waxes, such as ceresin, ozokerite or earth wax; (ii) chemically modified waxes, such as montana ester waxes, Sasol waxes, hydrogenated jojoba waxes; (iii) synthetic waxes, such as polyalkylene waxes, polyalkylene glycol waxes.

22. Use of the oily dispersion, as defined in claims 15 to 21, characterized in that it is for application to a plant and / or soil in an agronomic treatment method.

23. Process for preparing the oily dispersion, as defined in claims 15 to 21, characterized by the fact that it comprises the following steps: (a) mixing the oily agronomic active ingredient with the wax, at a temperature higher than the melting point of the wax; (b) cooling the product of step (a) at a temperature below the melting point of the wax; (c) mix the product of step (b) with a lipophilic solvent and a surfactant, to obtain an oily dispersion, wherein: the weight ratio of the oily agronomic active ingredient to the wax is between 1.20:1 and 3.80:1, preferably between 1.50:1 and 3.60:1, most preferably between 1.80:1 and 3.40:

1.

24. Process, according to claim 23, characterized in that: the weight ratio of the lipophilic solvent to the oily agronomic active ingredient is between 1:1 and 3:1, preferably between 1.2:1 and 2.7:1; more preferably between 1.3:1 and 2.4:1; and the weight ratio of surfactant to oily agronomic active ingredient is between 0.20:1 and 0.90:1, preferably between 0.24:1 and 0.80:1; more preferably between 0.28:1 and 0.70:

1. Petition 870250090272, dated 03 / 10 / 2025, pp. 121 / 124