Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway

Abstract

Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases as- sociated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.

Description

DEMANDE OU BREVET VOLUMINEUX LA PRÉSENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND PLUS D'UN TOME. CECI EST LE TOME 1 DE 2 CONTENANT LES PAGES 1 À 252 NOTE: Pour les tomes additionels, veuillez contacter le Bureau canadien des brevets JUMBO APPLICATIONS / PATENTS THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE THAN ONE VOLUME THIS IS VOLUME 1 OF 2 CONTAINING PAGES 1 TO 252 NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME : NOTE POUR LE TOME / VOLUME NOTE: DESCRIPTION BIARYL AMIDES WITH MODIFIED SUGAR GROUPS FOR TREATMENT OF DISEASES ASSOCIATED WITH HEAT SHOCK PROTEIN PATHWAY Background of the Invention I. Field of the Invention The present invention relates generally to the fields of biology, chemistry, and medicine. More particularly, it concerns compounds, compositions and methods for the treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy. II. Description of Related Art The heat shock protein 90 (Hsp90) is associated with a wide variety of disorders which result from the misfolding of one or more proteins. These disorders include neurological diseases associated with damage, loss of function, or death of a neuron. These diseases may affect either peripheral neurons (peripheral neuropathy) or central neurons (central neuropathy) and result from systemic diseases or conditions such as diabetes, leprosy, vitamin deficiencies, medication, or diseases of the immune system or from conditions such as a viral infection or a traumatic injury. Damage to peripheral neurons due to diabetes is known as diabetic peripheral neuropathy and can result in nerve damage to any organ of the body. This condition can lead to a variety of different symptoms, but the hallmark symptom is chronic pain, numbness, and tingling, particularly in the distal extremities. In 2010, approximately 132 million people are believed to have diabetic peripheral neuropathy, which is the most common complication from diabetes and leading source of morbidity and mortality in diabetes. Neckers and coworkers reported that the DNA gyrase inhibitor, novobiocin, and related natural products bind to the Hsp90 C-terminus nucleotide binding pocket with low affinity (IC50 ~700 μM) (Marcu, et al., 2000), while retaining similar biological activity. Previous studies have shown that the coumarin core of novobiocin can be replaced with a biphenyl core (Kusuma, et al., 2012). While the initial biphenyl analogs contained a noviose sugar moiety, this sugar group is synthetically challenging, requiring as many as ten steps to obtain (Yu, et al., 2005b; Beaver, et al., 2008; Zhao, et al., 2011). Moreover, the glycosylation of activated noviose sugar with the biphenyl moiety produced a mixture of anomers, which increased the difficulty of obtaining a single anomer. Thus, replacing this group without sacrificing activity or other pharmacological properties is of commercial interest. Additionally, a replacement group which shows other beneficial properties such as improved activity, stability, solubility, or any subset of these and / or other properties is important for developing compounds with the potential for treating and / or preventing diseases or disorders, including those associated with Hsp90. Binding to the C-terminus of Hsp90 may have therapeutic advantages in comparison to inhibitors that bind to the N-terminus (Kusuma, 2012). In particular, there remains a need for additional compounds with unique biological and pharmacological profiles for use in the treatment of diseases and disorders associated with the heat shock protein pathway, including inhibition of Hsp90 and / or induction of Hsp70. Summary of the Invention The present disclosure provides biaryl Hsp90 inhibitors with modified ether groups with therapeutic properties, pharmaceutical compositions thereof, methods for their manufacture, and methods for their use. In some aspects, the present disclosure provides compounds of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl(C \le 6), alkenyl(C \le 6), alkynyl(C \le 6), cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C leq 6), substituted alkyl(C leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> İS carboxy or <semantics>alkyl(C≤6),<annotation encoding="application / x-tex">alkyl_{(C\leq 6)},< / annotation>< / semantics> alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>); <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralky<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \leq 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C≤6), substituted alkyl(C≤6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is hydrogen, carboxy or <semantics>alkyl(C≤6)<annotation encoding="application / x-tex">alkyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>); <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> and <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> is amino or alkylamino(C \le 6), dialkylamino(C \le 12), amido(C \le 12), or a substituted version of any of these three groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido(C <semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxydiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C leq 6), substituted alkyl(C leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alkyl(C3-8), alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy, or alkyl(C3-8), alkenyl(C\leq 8), alkynyl(C\leq 8), cycloalkyl(C\leq 8), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), aralkyl(<semantics>C≤12<annotation encoding="application / x-tex">C \le 12< / annotation>< / semantics>), aralkoxy(<semantics>C≤12<annotation encoding="application / x-tex">C \le 12< / annotation>< / semantics>), or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \le 6), alkenediyl(C \le 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics> or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy, or alkyl(C≤8), alkenyl(C≤8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl(C \le 12), <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>–OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralky<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \le 6), alkenediyl(C \le 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is substituted -alkanediyl(C \leq 6)-, -C(O)-alkanediyl(C \leq 6)-, or substituted <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \leq 6)-; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy or alkyl(C \leq 8), alkenyl(C \leq 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalkyl(C \le 8), <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroaryl(C \le 12), aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of any of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralky<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (III) wherein: n is 1 or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8),heterocycloalkyl(C≤8),aryl(C≤12),aralkyl(C≤12),amido(C≤6),<annotation encoding="application / x-tex">cycloalkyl_{(C\leq 8)}, \quad heterocycloalkyl_{(C\leq 8)}, \quad aryl_{(C\leq 12)}, \quad aralkyl_{(C\leq 12)}, \quad amido_{(C\leq 6)},< / annotation>< / semantics> alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \leq 6), substituted alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy, or alkyl(C \le 8), alkenyl(C \le 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \leq 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \leq 6), substituted alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>ℝ7<annotation encoding="application / x-tex">\mathbb{R}_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤8)<annotation encoding="application / x-tex">alkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy, or alkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are <semantics>−alkanediyl(C≤7)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 7)}< / annotation>< / semantics>, <semantics>−alkenediyl(C≤7)<annotation encoding="application / x-tex">-alkenediyl_{(C \le 7)}< / annotation>< / semantics>, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is halo, alkoxy(C3-6), acyloxy(C≤6), aralkoxy(C≤12), or a substituted version of any of these groups; <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics> and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently halo, hydroxy, or alkyl(C≤6), alkoxy(C≤6), acyl(C≤6), <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>—heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \le 6), alkenediyl(C \le 6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8),heterocycloalkyl(C≤8),amido(C≤6),alkoxy(C≤6),alkylsulfonyl(C≤6),<annotation encoding="application / x-tex">cycloalkyl_{(C\leq 8)},\ heterocycloalkyl_{(C\leq 8)},\ amido_{(C\leq 6)},\ alkoxy_{(C\leq 6)},\ alkylsulfonyl_{(C\leq 6)},< / annotation>< / semantics> or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8),heterocycloalkyl(C≤8),aryl(C≤12),aralkyl(C≤12),amido(C≤6),<annotation encoding="application / x-tex">cycloalkyl_{(C\leq 8)}, \quad heterocycloalkyl_{(C\leq 8)}, \quad aryl_{(C\leq 12)}, \quad aralkyl_{(C\leq 12)}, \quad amido_{(C\leq 6)},< / annotation>< / semantics> <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylthio(C≤6)<annotation encoding="application / x-tex">alkylthio_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6); <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy or alkyl(C \leq 8), alkenyl(C \leq 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>heterocycloalkyl(C≤8)<annotation encoding="application / x-tex">heterocycloalkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, <semantics>heteroaryl(C≤12)<annotation encoding="application / x-tex">heteroaryl_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are <semantics>−alkanediyl(C≤7)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 7)}< / annotation>< / semantics>, <semantics>−alkenediyl(C≤7)<annotation encoding="application / x-tex">-alkenediyl_{(C \le 7)}< / annotation>< / semantics>, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralky<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (IV) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl(C \le 6), alkenyl(C \le 6), alkynyl(C \le 6), cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C≤6), substituted alkyl(C≤6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤8)<annotation encoding="application / x-tex">alkyl_{(C\leq 8)}< / annotation>< / semantics>, alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy or alkyl(C \leq 8), alkenyl(C \leq 8), alkynyl(C \leq 8), cycloalkyl(C \leq 8), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (V) wherein: <semantics>R16<annotation encoding="application / x-tex">R_{16}< / annotation>< / semantics> is alkyl(C≤12), cycloalkyl(C≤12), aryl(C≤18), heteroaryl(C≤18), or a substituted version thereof; <semantics>R17<annotation encoding="application / x-tex">R_{17}< / annotation>< / semantics> and <semantics>R18<annotation encoding="application / x-tex">R_{18}< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 8), or substituted alkyl(C \leq 8); <semantics>R19<annotation encoding="application / x-tex">R_{19}< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤8)<annotation encoding="application / x-tex">alkyl_{(C\leq 8)}< / annotation>< / semantics>, alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted <semantics>R19′<annotation encoding="application / x-tex">R_{19}'< / annotation>< / semantics> is hydrogen, carboxy or alkyl(C \leq 8), alkenyl(C \leq 8), alkynyl(C \leq 8), cycloalkyl(C \leq 8), heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>; <semantics>R20<annotation encoding="application / x-tex">R_{20}< / annotation>< / semantics>, <semantics>R21<annotation encoding="application / x-tex">R_{21}< / annotation>< / semantics>, and <semantics>R22<annotation encoding="application / x-tex">R_{22}< / annotation>< / semantics> are each independently halo, hydroxy, or alkyl(C \le 6), alkoxy(C \le 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups, or a protected hydroxy group; or a pharmaceutically acceptable salt of any of the above formulas. In some embodiments, the compounds are further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfony<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>ℝ7<annotation encoding="application / x-tex">\mathbb{R}_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤6)<annotation encoding="application / x-tex">alkyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \le 6), alkoxy(C \le 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \leq 6), substituted alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is hydrogen, carboxy or <semantics>alkyl(C≤6)<annotation encoding="application / x-tex">alkyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, <semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics><semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> and <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \leq 6), alkoxy(C \leq 6), acyl(C \leq 6), <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> is amino or alkylamino<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, dialkylamino<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these three groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>—heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl(C \le 6), alkenyl(C \le 6), alkynyl(C \le 6), cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \leq 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxydiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl(C≤6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C3−8)<annotation encoding="application / x-tex">alkyl_{(C3-8)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C\leq 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C\leq 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C\leq 8)}< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy, or alkyl<semantics>(C3−8)<annotation encoding="application / x-tex">_{(C_3-8)}< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C_{\le 8)}}< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C_{\le 8)}}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C_{\le 8)}}< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \le 7)-, -alkenediyl(C \le 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \le 6), alkoxy(C \le 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics> or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl(C \le 6), alkenyl(C \le 6), alkynyl(C \le 6), cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido(C <semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylthio(C≤6)<annotation encoding="application / x-tex">alkylthio_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C≤6), substituted alkyl(C≤6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy, or alkyl(C≤8), alkenyl(C≤8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl(C \le 12), <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>–<semantics>OR13<annotation encoding="application / x-tex">OR_{13}< / annotation>< / semantics>, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \le 6), alkoxy(C \le 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is substituted -alkanediyl(C≤6)-, -C(O)-alkanediyl(C≤6)-, or substituted <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \leq 6)-; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy or alkyl(C \leq 8), alkenyl(C \leq 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl(C \le 12), <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>–OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of any of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \leq 6), alkoxy(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (III) wherein: n is 1 or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy, or alkyl(C \leq 8), alkenyl(C \leq 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalkyl(C \le 8), <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroaryl(C \le 12), aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylaminodiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl(C≤6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C\leq 6), or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C≤6), substituted alkyl(C≤6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>ℝ7<annotation encoding="application / x-tex">\mathbb{R}_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤8),<annotation encoding="application / x-tex">alkyl_{(C\leq 8)},< / annotation>< / semantics> alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy, or alkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is alkoxy(C3-6), acyloxy(C≤6), aralkoxy(C≤12), or a substituted version of any of these groups; <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics> and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydroxy, or alkyl(C \leq 6), alkoxy(C \leq 6), acyl(C \leq 6), <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] <semantics>(Π)<annotation encoding="application / x-tex">(\Pi)< / annotation>< / semantics> wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \leq 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl(C≤6); <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy or alkyl(C\leq 8), alkenyl(C\leq 8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalkyl(C \le 8), <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroaryl(C \le 12), <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl(C \le 12), <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are <semantics>−alkanediyl(C≤7)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 7)}< / annotation>< / semantics>, <semantics>−alkenediyl(C≤7)<annotation encoding="application / x-tex">-alkenediyl_{(C \le 7)}< / annotation>< / semantics>, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \le 6), alkoxy(C \le 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (IV) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylthio(C≤6)<annotation encoding="application / x-tex">alkylthio_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \leq 6), substituted alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>ℝ7<annotation encoding="application / x-tex">\mathbb{R}_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤8),<annotation encoding="application / x-tex">alkyl_{(C\leq 8)},< / annotation>< / semantics> alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy or alkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤12), or substituted aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are <semantics>−alkanediyl(C≤7)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 7)}< / annotation>< / semantics>, <semantics>−alkenediyl(C≤7)<annotation encoding="application / x-tex">-alkenediyl_{(C \le 7)}< / annotation>< / semantics>, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyloxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylaminodiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (V) wherein: <semantics>R16<annotation encoding="application / x-tex">R_{16}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aryl<semantics>(C≤18)<annotation encoding="application / x-tex">_{(C \le 18)}< / annotation>< / semantics>, heteroaryl<semantics>(C≤18)<annotation encoding="application / x-tex">_{(C \le 18)}< / annotation>< / semantics>, or a substituted version thereof; <semantics>R17<annotation encoding="application / x-tex">R_{17}< / annotation>< / semantics> and <semantics>R18<annotation encoding="application / x-tex">R_{18}< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤8), or substituted alkyl(C≤8); <semantics>R19<annotation encoding="application / x-tex">R_{19}< / annotation>< / semantics> is <semantics>alkyl(C≤8)<annotation encoding="application / x-tex">alkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, heterocycloalkyl(C \le 8), <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups <semantics>R20<annotation encoding="application / x-tex">R_{20}< / annotation>< / semantics>, <semantics>R21<annotation encoding="application / x-tex">R_{21}< / annotation>< / semantics>, and <semantics>R22<annotation encoding="application / x-tex">R_{22}< / annotation>< / semantics> are each independently hydroxy, alkoxy(C \leq 12), substituted alkoxy(C \leq 12), or a protected hydroxy group; or a pharmaceutically acceptable salt of any of the above formulas. In some embodiments, the compounds are further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl(C≤6), alkenyl(C≤6), alkynyl(C≤6), cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxydiy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤6),<annotation encoding="application / x-tex">alkyl_{(C\leq 6)},< / annotation>< / semantics> alkenyl(C <semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C <semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C <semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C \leq 6), alkoxy(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">_{(C \le 8)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">_{(C \le 6)}< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylthio<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), substituted alkyl(C \leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \leq 6), substituted alkyl(C \leq 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>𝑹7<annotation encoding="application / x-tex">\mathbf{R}_{7}< / annotation>< / semantics> is carboxy or <semantics>alkyl(C3−8),<annotation encoding="application / x-tex">alkyl_{(C3-8)},< / annotation>< / semantics> <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, -alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> is hydrogen, carboxy, or alkyl(C3-8), alkenyl(C≤8), alkynyl(C≤8), cycloalkyl(C≤8), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); or <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C leq 6), alkoxy(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \le 6), alkenediyl(C \le 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>—heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics> or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>, amido<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkoxy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, alkylsulfony<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \leq 6)}< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C leq 6), substituted alkyl(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C \leq 6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently hydrogen, halo, alkyl(C \le 6), substituted alkyl(C \le 6), alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), substituted alkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are each independently hydrogen, carboxy, or alkyl(C≤8), alkenyl(C≤8), <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, cycloalkyl(C \le 8), heterocycloalkyl(C \le 8), <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroaryl(C \le 12), aralkyl(C≤12), heteroaralkyl(C≤12), <semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>alkanediyl(C≤6)<semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> and <semantics>R7′<annotation encoding="application / x-tex">R_7'< / annotation>< / semantics> are taken together and are -alkanediyl(C \leq 7)-, -alkenediyl(C \leq 7)-, or a substituted version of either of these groups; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C leq 6), alkoxy(C leq 6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkenediyl(C \leq 6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl(C \leq 6), alkenyl(C \leq 6), alkynyl(C \leq 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C \leq 6), alkoxydiyl(C \leq 6), alkylaminodiyl(C<semantics>≤<annotation encoding="application / x-tex">\leq< / annotation>< / semantics>6), or a substituted version of any of these groups; or a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (II) wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is substituted -alkanediyl(C \leq 6)-, -C(O)-alkanediyl(C \leq 6)-, or substituted <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C≤6)-; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>heterocycloalkyl(C≤8)<annotation encoding="application / x-tex">heterocycloalkyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / sem...

Claims

<pat:ClaimStatement>CLAIMS What is Claimed is:< / pat:ClaimStatement> <pat:Claims com:id="claims"> <pat:Claim com:id="CLM-00001"> <pat:ClaimNumber>1< / pat:ClaimNumber> <pat:ClaimText>1. A compound of the formula [Image disponible dans le document PDF, Image available in the PDF document] < / / wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylthio(C≤6)<annotation encoding="application / x-tex">alkylthio_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; R4, R5, and R6 are each independently hydrogen; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alkyl(C≤6), alkenyl(C≤8), alkynyl(C≤8), cycloalkyl(C≤8), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \le 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylamino<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, —alkanediy<semantics>l(C≤6)<annotation encoding="application / x-tex">l(C \le 6)< / annotation>< / semantics>—heterocycloalky<semantics>l(C≤8)<annotation encoding="application / x-tex">l(C \le 8)< / annotation>< / semantics>, or a substituted version of any of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00002"> <pat:ClaimNumber>2< / pat:ClaimNumber> <pat:ClaimText>2. The compound of claim 1 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-alkanediyl(C \le 6)-, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; R4, R5, and R6 are each independently hydrogen; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, ary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>), heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>); and <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \le 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00003"> <pat:ClaimNumber>3< / pat:ClaimNumber> <pat:ClaimText>3. The compound of either claim 1 or claim 2 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (VII), wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>, <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, or <semantics>S<annotation encoding="application / x-tex">S< / annotation>< / semantics>; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics> or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, acy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or substituted acy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkenyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, alkynyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>); and <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C≤6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00004"> <pat:ClaimNumber>4< / pat:ClaimNumber> <pat:ClaimText>4. The compound according to any one of claims 1-3 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (VIII), wherein: n is 0, 1, or 2; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or <semantics>alkyl(C≤6)<annotation encoding="application / x-tex">alkyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkenyl(C≤8)<annotation encoding="application / x-tex">alkenyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>alkynyl(C≤8)<annotation encoding="application / x-tex">alkynyl_{(C \le 8)}< / annotation>< / semantics>, <semantics>cycloalkyl(C≤8)<annotation encoding="application / x-tex">cycloalkyl_{(C \le 8)}< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, <semantics>aryl(C≤12)<annotation encoding="application / x-tex">aryl_{(C \le 12)}< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralkyl(C<semantics>≤12<annotation encoding="application / x-tex">\leq 12< / annotation>< / semantics>), heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, substituted alkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">_{(C \le 12)}< / annotation>< / semantics>, or substituted aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>; and <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, halo, hydroxy, or alkyl(C \le 6), <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00005"> <pat:ClaimNumber>5< / pat:ClaimNumber> <pat:ClaimText>5. The compound of claim 4 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (XXV) wherein: <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alkyl(C1-6), alkenyl(C2-8), alkynyl(C2-8), cycloalkyl(C3-8), aryl(C6-12), -alkanediyl(C1-6)-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is alkyl(C1-12), substituted alkyl(C1-12), aralkyl(C7-12), or substituted aralkyl(C7-12); and R8 is hydrogen, halo, hydroxy, or alkyl(C1-6), alkoxy(C1-6), acyl(C1-6), acyloxy(C1-6), aralkyl<semantics>(C7−12)<annotation encoding="application / x-tex">(C7-12)< / annotation>< / semantics>, aralkoxy<semantics>(C7−12)<annotation encoding="application / x-tex">(C7-12)< / annotation>< / semantics>, or a substituted version of any of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00006"> <pat:ClaimNumber>6< / pat:ClaimNumber> <pat:ClaimText>6. The compound of claim 5 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (XXV) wherein: R7 is alkyl(C1-6), alkenyl(C2-8), alkynyl(C2-8), or a substituted version of any of these groups; and R8 is hydrogen, hydroxy, or alkyl(C1-6), alkoxy(C1-6), or a substituted version of either of these groups; or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00007"> <pat:ClaimNumber>7< / pat:ClaimNumber> <pat:ClaimText>7. The compound of claim 6 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] (XXV) wherein: <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is alkyl(C1-6) or substituted alkyl(C1-6); and R8 is hydroxy, alkoxy(C1-6), or substituted alkoxy(C1-6); or a pharmaceutically acceptable salt of the formula. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00008"> <pat:ClaimNumber>8< / pat:ClaimNumber> <pat:ClaimText>8. The compound of claim 1, wherein <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00009"> <pat:ClaimNumber>9< / pat:ClaimNumber> <pat:ClaimText>9. The compound of claim 1, wherein <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is halo. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00010"> <pat:ClaimNumber>10< / pat:ClaimNumber> <pat:ClaimText>10. The compound of claim 9, wherein <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is fluoro. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00011"> <pat:ClaimNumber>11< / pat:ClaimNumber> <pat:ClaimText>11. The compound of claim 1, wherein <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00012"> <pat:ClaimNumber>12< / pat:ClaimNumber> <pat:ClaimText>12. The compound of claim 11, wherein <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00013"> <pat:ClaimNumber>13< / pat:ClaimNumber> <pat:ClaimText>13. The compound of claim 1, wherein <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00014"> <pat:ClaimNumber>14< / pat:ClaimNumber> <pat:ClaimText>14. The compound of claim 13, wherein <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00015"> <pat:ClaimNumber>15< / pat:ClaimNumber> <pat:ClaimText>15. The compound according to any one of claims 1-3, wherein <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00016"> <pat:ClaimNumber>16< / pat:ClaimNumber> <pat:ClaimText>16. The compound of claim 15, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00017"> <pat:ClaimNumber>17< / pat:ClaimNumber> <pat:ClaimText>17. The compound of claim 15, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics> or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00018"> <pat:ClaimNumber>18< / pat:ClaimNumber> <pat:ClaimText>18. The compound of claim 17, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00019"> <pat:ClaimNumber>19< / pat:ClaimNumber> <pat:ClaimText>19. The compound of claim 18, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is methyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00020"> <pat:ClaimNumber>20< / pat:ClaimNumber> <pat:ClaimText>20. The compound of claim 15, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics> or substituted <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00021"> <pat:ClaimNumber>21< / pat:ClaimNumber> <pat:ClaimText>21. The compound of claim 20, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00022"> <pat:ClaimNumber>22< / pat:ClaimNumber> <pat:ClaimText>22. The compound of claim 21, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is acetyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00023"> <pat:ClaimNumber>23< / pat:ClaimNumber> <pat:ClaimText>23. The compound according to any one of claims 15-22, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics>' is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00024"> <pat:ClaimNumber>24< / pat:ClaimNumber> <pat:ClaimText>24. The compound according to any one of claims 15-22, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> is alkyl(C<6) or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00025"> <pat:ClaimNumber>25< / pat:ClaimNumber> <pat:ClaimText>25. The compound of claim 24, wherein <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00026"> <pat:ClaimNumber>26< / pat:ClaimNumber> <pat:ClaimText>26. The compound of claim 25, wherein <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics>' is methyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00027"> <pat:ClaimNumber>27< / pat:ClaimNumber> <pat:ClaimText>27. The compound according to any one of claims 1-3, wherein <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00028"> <pat:ClaimNumber>28< / pat:ClaimNumber> <pat:ClaimText>28. The compound of claim 27, wherein <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00029"> <pat:ClaimNumber>29< / pat:ClaimNumber> <pat:ClaimText>29. The compound of either claim 27 or claim 28, wherein <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00030"> <pat:ClaimNumber>30< / pat:ClaimNumber> <pat:ClaimText>30. The compound of either claim 1 or claim 2, wherein R4 is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00031"> <pat:ClaimNumber>31< / pat:ClaimNumber> <pat:ClaimText>31. The compound of either claim 1 or claim 2, wherein R5 is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00032"> <pat:ClaimNumber>32< / pat:ClaimNumber> <pat:ClaimText>32. The compound of either claim 1 or claim 2, wherein <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00033"> <pat:ClaimNumber>33< / pat:ClaimNumber> <pat:ClaimText>33. The compound according to any one of claims 1-4, wherein <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is O. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00034"> <pat:ClaimNumber>34< / pat:ClaimNumber> <pat:ClaimText>34. The compound according to any one of claims 1-4, wherein <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is S. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00035"> <pat:ClaimNumber>35< / pat:ClaimNumber> <pat:ClaimText>35. The compound according to any one of claims 1-4, wherein <semantics>Y2<annotation encoding="application / x-tex">Y_2< / annotation>< / semantics> is <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00036"> <pat:ClaimNumber>36< / pat:ClaimNumber> <pat:ClaimText>36. The compound according to any one of claims 1-4, wherein n is 1 or 2. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00037"> <pat:ClaimNumber>37< / pat:ClaimNumber> <pat:ClaimText>37. The compound according to any one of claims 1-4, wherein n is 0 or 1. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00038"> <pat:ClaimNumber>38< / pat:ClaimNumber> <pat:ClaimText>38. The compound of either claim 36 or claim 37, wherein n is 1. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00039"> <pat:ClaimNumber>39< / pat:ClaimNumber> <pat:ClaimText>39. The compound of claim 37, wherein n is 0. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00040"> <pat:ClaimNumber>40< / pat:ClaimNumber> <pat:ClaimText>40. The compound according to any one of claims 1-4, wherein R9 is hydroxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00041"> <pat:ClaimNumber>41< / pat:ClaimNumber> <pat:ClaimText>41. The compound according to any one of claims 1-4, wherein R9 is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00042"> <pat:ClaimNumber>42< / pat:ClaimNumber> <pat:ClaimText>42. The compound according to any one of claims 1-4, wherein <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> is hydroxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00043"> <pat:ClaimNumber>43< / pat:ClaimNumber> <pat:ClaimText>43. The compound according to any one of claims 1-4, wherein <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> is hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00044"> <pat:ClaimNumber>44< / pat:ClaimNumber> <pat:ClaimText>44. The compound according to any one of claims 1-4, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is hydroxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00045"> <pat:ClaimNumber>45< / pat:ClaimNumber> <pat:ClaimText>45. The compound according to any one of claims 1-4, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics> or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00046"> <pat:ClaimNumber>46< / pat:ClaimNumber> <pat:ClaimText>46. The compound of claim 45, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00047"> <pat:ClaimNumber>47< / pat:ClaimNumber> <pat:ClaimText>47. The compound of claim 46, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is methyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00048"> <pat:ClaimNumber>48< / pat:ClaimNumber> <pat:ClaimText>48. The compound according to any one of claims 1-4, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is alkoxy(C \le 6) or substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00049"> <pat:ClaimNumber>49< / pat:ClaimNumber> <pat:ClaimText>49. The compound of claim 48, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is alkoxy(C \le 6). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00050"> <pat:ClaimNumber>50< / pat:ClaimNumber> <pat:ClaimText>50. The compound of claim 49, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is methoxy or isopropoxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00051"> <pat:ClaimNumber>51< / pat:ClaimNumber> <pat:ClaimText>51. The compound of claim 48, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is substituted alkoxy(C≤6). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00052"> <pat:ClaimNumber>52< / pat:ClaimNumber> <pat:ClaimText>52. The compound of claim 51, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is difluoromethoxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00053"> <pat:ClaimNumber>53< / pat:ClaimNumber> <pat:ClaimText>53. The compound according to any one of claims 1-4, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is aralkoxy(C<6) or substituted aralkoxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00054"> <pat:ClaimNumber>54< / pat:ClaimNumber> <pat:ClaimText>54. The compound of claim 53, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is aralkoxy(C \le 6). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00055"> <pat:ClaimNumber>55< / pat:ClaimNumber> <pat:ClaimText>55. The compound of claim 53, wherein <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics> is benzyloxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00056"> <pat:ClaimNumber>56< / pat:ClaimNumber> <pat:ClaimText>56. The compound according to any one of claims 1-5 and 8 to 55, wherein R7 is carboxy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00057"> <pat:ClaimNumber>57< / pat:ClaimNumber> <pat:ClaimText>57. The compound according to any one of claims 1 to 55, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics> or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00058"> <pat:ClaimNumber>58< / pat:ClaimNumber> <pat:ClaimText>58. The compound of claim 57, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00059"> <pat:ClaimNumber>59< / pat:ClaimNumber> <pat:ClaimText>59. The compound of claim 58, wherein R7 is methyl, propyl, or isobutyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00060"> <pat:ClaimNumber>60< / pat:ClaimNumber> <pat:ClaimText>60. The compound of claim 57, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is substituted alkyl(C \le 6). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00061"> <pat:ClaimNumber>61< / pat:ClaimNumber> <pat:ClaimText>61. The compound of claim 60, wherein R7 is hydroxymethyl, fluoromethyl, hydoxyethyl, or fluoroisopropyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00062"> <pat:ClaimNumber>62< / pat:ClaimNumber> <pat:ClaimText>62. The compound according to any one of claims 1-6 and 8 to 55, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is alkenyl(C\le 8) or substituted alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00063"> <pat:ClaimNumber>63< / pat:ClaimNumber> <pat:ClaimText>63. The compound of claim 62, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is alkenyl(C \le 8). < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00064"> <pat:ClaimNumber>64< / pat:ClaimNumber> <pat:ClaimText>64. The compound of claim 63, wherein R7 is allyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00065"> <pat:ClaimNumber>65< / pat:ClaimNumber> <pat:ClaimText>65. The compound according to any one of claims 1-5 and 8 to 55, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is <semantics>aryl(C≤8)<annotation encoding="application / x-tex">aryl_{(C \le 8)}< / annotation>< / semantics> or substituted ary <semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00066"> <pat:ClaimNumber>66< / pat:ClaimNumber> <pat:ClaimText>66. The compound of claim 65, wherein <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is <semantics>aryl(C≤8)<annotation encoding="application / x-tex">aryl_{(C \le 8)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00067"> <pat:ClaimNumber>67< / pat:ClaimNumber> <pat:ClaimText>67. The compound of claim 66, wherein R7 is phenyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00068"> <pat:ClaimNumber>68< / pat:ClaimNumber> <pat:ClaimText>68. The compound according to any one of claims 1-5 and 8 to 55, wherein R7 is <semantics>−alkanediyl(C≤6)−OR13<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)} -OR_{13}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00069"> <pat:ClaimNumber>69< / pat:ClaimNumber> <pat:ClaimText>69. The compound of claim 68, wherein <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \le 8)}< / annotation>< / semantics>. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00070"> <pat:ClaimNumber>70< / pat:ClaimNumber> <pat:ClaimText>70. The compound of claim 69, wherein <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is benzyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00071"> <pat:ClaimNumber>71< / pat:ClaimNumber> <pat:ClaimText>71. The compound of claim 1, wherein the compound is further defined as: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , • , С . [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or a pharmaceutically acceptable salt of any of these formulas. フ < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00072"> <pat:ClaimNumber>72< / pat:ClaimNumber> <pat:ClaimText>72. The compound of claim 71 further defined as: [Image disponible dans le document PDF, Image available in the PDF document] or a pharmaceutically acceptable salt of any of these formulas. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00073"> <pat:ClaimNumber>73< / pat:ClaimNumber> <pat:ClaimText>73. A pharmaceutical composition comprising: (A) a compound according to any one of claims 1-72; and (B) an excipient. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00074"> <pat:ClaimNumber>74< / pat:ClaimNumber> <pat:ClaimText>74. The pharmaceutical composition of claim 73, wherein the pharmaceutical composition is formulated for administration: orally, intraadiposally, intraarterially, intraarticularly, intracranially, intradermally, intralesionally, intramuscularly, intranasally, intraocularly, intrapericardially, intraperitoneally, intrapleurally, intraprostatically, intrarectally, intrathecally, intratracheally, intratumorally, intraumbilically, intravaginally, intravenously, intravesicularly, intravitreally, liposomally, locally, mucosally, parenterally, rectally, subconjunctival, subcutaneously, sublingually, topically, transbuccally, transdermally, vaginally, in crèmes, in lipid compositions, via a catheter, via a lavage, via continuous infusion, via infusion, via inhalation, via injection, via local delivery, or via localized perfusion. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00075"> <pat:ClaimNumber>75< / pat:ClaimNumber> <pat:ClaimText>75. The pharmaceutical composition of claim 74, wherein the pharmaceutical composition is formulated for oral, intraarterial, or intravenous administration. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00076"> <pat:ClaimNumber>76< / pat:ClaimNumber> <pat:ClaimText>76. The pharmaceutical composition according to any one of claims 73-75 wherein the pharmaceutical composition is formulated as a unit dose. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00077"> <pat:ClaimNumber>77< / pat:ClaimNumber> <pat:ClaimText>77. A use of a compound according to any one of claims 1-72 or a composition according to any one of claims 73-76 for treating a disease or disorder in a patient. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00078"> <pat:ClaimNumber>78< / pat:ClaimNumber> <pat:ClaimText>78. The use of claim 77, wherein the disease or disorder is a neurological disorder. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00079"> <pat:ClaimNumber>79< / pat:ClaimNumber> <pat:ClaimText>79. The use of claim 77, wherein the disease or disorder is diabetes or a complication thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00080"> <pat:ClaimNumber>80< / pat:ClaimNumber> <pat:ClaimText>80. The use of claim 79, wherein the disease or disorder is a complication from diabetes. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00081"> <pat:ClaimNumber>81< / pat:ClaimNumber> <pat:ClaimText>81. The use of claim 80, wherein the complication from diabetes is neuropathy, nephropathy, retinopathy, or vasculopathy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00082"> <pat:ClaimNumber>82< / pat:ClaimNumber> <pat:ClaimText>82. The use of claim 81, wherein the complication from diabetes is neuropathy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00083"> <pat:ClaimNumber>83< / pat:ClaimNumber> <pat:ClaimText>83. The use according to claim 77, wherein the disease or disorder is diabetic peripheral neuropathy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00084"> <pat:ClaimNumber>84< / pat:ClaimNumber> <pat:ClaimText>84. The use of claim 77, wherein the disease or disorder is cancer. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00085"> <pat:ClaimNumber>85< / pat:ClaimNumber> <pat:ClaimText>85. The use according to any one of claims 77-84, wherein the disease or disorder is associated with misregulation of the Hsp70 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00086"> <pat:ClaimNumber>86< / pat:ClaimNumber> <pat:ClaimText>86. The use according to any one of claims 77-85, wherein the disease or disorder is associated with misregulation of the Hsp90 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00087"> <pat:ClaimNumber>87< / pat:ClaimNumber> <pat:ClaimText>87. The use according to any one of claims 77-86, wherein the patient is a mammal. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00088"> <pat:ClaimNumber>88< / pat:ClaimNumber> <pat:ClaimText>88. The use of according to any one of claims 77-86, wherein the patient is human. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00089"> <pat:ClaimNumber>89< / pat:ClaimNumber> <pat:ClaimText>89. The use according to any one of claims 77-88, wherein the compound is for administration once to the patient. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00090"> <pat:ClaimNumber>90< / pat:ClaimNumber> <pat:ClaimText>90. The use according to any one of claims 77-88, wherein the compound is for administration two or more times to the patient. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00091"> <pat:ClaimNumber>91< / pat:ClaimNumber> <pat:ClaimText>91. An in vitro method of inducing expression of a Hsp70 protein comprising contacting the protein with an effective amount of a compound according to any one of claims 1-72 or a composition according to any one of claims 73-76 sufficient to induce the expression of the Hsp70 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00092"> <pat:ClaimNumber>92< / pat:ClaimNumber> <pat:ClaimText>92. The method according to claim 91, wherein the effective amount of a compound or composition is effective enough to induce expression by at least 50% of the Hsp70 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00093"> <pat:ClaimNumber>93< / pat:ClaimNumber> <pat:ClaimText>93. The method of claim 92, wherein the Hsp70 protein expression is induced by more than 100%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00094"> <pat:ClaimNumber>94< / pat:ClaimNumber> <pat:ClaimText>94. The method according to any one of claims 91-93, wherein the induction of Hsp70 protein expression results in a modulation in expression of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00095"> <pat:ClaimNumber>95< / pat:ClaimNumber> <pat:ClaimText>95. The method according to any one of claims 91-94, wherein the induction of Hsp70 protein expression results in a modulation in activity of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00096"> <pat:ClaimNumber>96< / pat:ClaimNumber> <pat:ClaimText>96. A use of an effective amount of a compound according to any one of claims 1-72 or a composition according to any one of claims 73-76 for inducing expression of a Hsp70 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00097"> <pat:ClaimNumber>97< / pat:ClaimNumber> <pat:ClaimText>97. The use according to claim 96, wherein the effective amount of a compound or composition is effective enough to induce expression by at least 50% of the Hsp70 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00098"> <pat:ClaimNumber>98< / pat:ClaimNumber> <pat:ClaimText>98. The use of claim 97, wherein the Hsp70 protein expression is induced by more than 100%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00099"> <pat:ClaimNumber>99< / pat:ClaimNumber> <pat:ClaimText>99. The use according to any one of claims 96-98, wherein the induction of Hsp70 protein expression is sufficient to treat a disease or disorder. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00100"> <pat:ClaimNumber>100< / pat:ClaimNumber> <pat:ClaimText>100. The use of claim 99, wherein the disease or disorder is a neurodegenerative disease. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00101"> <pat:ClaimNumber>101< / pat:ClaimNumber> <pat:ClaimText>101. The use of claim 100, wherein the neurodegenerative disease is associated with misfolded proteins, demyelination, inflammation, and neuropathy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00102"> <pat:ClaimNumber>102< / pat:ClaimNumber> <pat:ClaimText>102. The use of claim 100, wherein the neurodegenerative disease is diabetic peripheral neuropathy. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00103"> <pat:ClaimNumber>103< / pat:ClaimNumber> <pat:ClaimText>103. The use according to any one of claims 96-102, wherein the induction of Hsp70 protein expression results in a modulation in expression of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00104"> <pat:ClaimNumber>104< / pat:ClaimNumber> <pat:ClaimText>104. The use according to any one of claims 96-102, wherein the induction of Hsp70 protein expression results in a modulation in activity of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00105"> <pat:ClaimNumber>105< / pat:ClaimNumber> <pat:ClaimText>105. A in vitro method of inhibiting of a Hsp90 protein comprising contacting the protein with an effective amount of a compound according to any one of claims 1-72 or a composition according to any one of claims 73-76 sufficient to inhibit the activity of the Hsp90 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00106"> <pat:ClaimNumber>106< / pat:ClaimNumber> <pat:ClaimText>106. The method according to claim 105, wherein the effective amount of a compound or composition is effective enough to inhibit the expression of the Hsp90 protein by at least 50%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00107"> <pat:ClaimNumber>107< / pat:ClaimNumber> <pat:ClaimText>107. The method of claim 106, wherein the Hsp90 protein expression is inhibited by more than 75%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00108"> <pat:ClaimNumber>108< / pat:ClaimNumber> <pat:ClaimText>108. The method according to any one of claims 105-107, wherein the inhibition of Hsp90 protein expression results in a modulation in expression of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00109"> <pat:ClaimNumber>109< / pat:ClaimNumber> <pat:ClaimText>109. The method according to any one of claims 105-108, wherein the inhibition of Hsp90 protein expression results in a modulation in activity of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00110"> <pat:ClaimNumber>110< / pat:ClaimNumber> <pat:ClaimText>110. A use of an effective amount of a compound according to any one of claims 1-72 or a composition according to any one of claims 73-76 for inhibiting a Hsp90 protein. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00111"> <pat:ClaimNumber>111< / pat:ClaimNumber> <pat:ClaimText>111. The use according claim 110, wherein the effective amount of a compound or composition is effective enough to inhibit the expression of the Hsp90 protein by at least 50%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00112"> <pat:ClaimNumber>112< / pat:ClaimNumber> <pat:ClaimText>112. The use of claim 110, wherein the Hsp90 protein expression is inhibited by more than 75%. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00113"> <pat:ClaimNumber>113< / pat:ClaimNumber> <pat:ClaimText>113. The use according to any one of claims 110-112, wherein the inhibition of Hsp90 protein expression is sufficient to treat a disease or disorder. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00114"> <pat:ClaimNumber>114< / pat:ClaimNumber> <pat:ClaimText>114. The use of claim 113, wherein the disease or disorder is cancer or a hyperproliferative disorder. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00115"> <pat:ClaimNumber>115< / pat:ClaimNumber> <pat:ClaimText>115. The use of claim 113, wherein the disease or disorder is associated with a highly proliferating cell. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00116"> <pat:ClaimNumber>116< / pat:ClaimNumber> <pat:ClaimText>116. The use according to any one of claims 110-115 wherein the inhibition of Hsp90 protein expression results in a modulation in expression of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00117"> <pat:ClaimNumber>117< / pat:ClaimNumber> <pat:ClaimText>117. The use according to any one of claims 110-115, wherein the inhibition of Hsp90 protein expression results in a modulation in activity of one or more downstream products. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00118"> <pat:ClaimNumber>118< / pat:ClaimNumber> <pat:ClaimText>118. A compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (XXXIII), wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-<semantics>C(O)R17<annotation encoding="application / x-tex">C(O)R_{17}< / annotation>< / semantics>, or a substituted version of any of these groups, wherein: <semantics>R17<annotation encoding="application / x-tex">R_{17}< / annotation>< / semantics> is alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics> or substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; Y2 is hydroxy or mercapto; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or a substituted version of any of these groups; R2 is fluoro; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is carboxy, <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics>, or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or substituted acyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>); <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently absent, hydrogen, halo, alkyl(C≤6), substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, substituted aralkoxy(<semantics>C≤12<annotation encoding="application / x-tex">C \le 12< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylamino<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, -alkanediy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-heterocycloalky<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; and <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; provided that the compound is not a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] • < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00119"> <pat:ClaimNumber>119< / pat:ClaimNumber> <pat:ClaimText>119. The compound of claim 118, wherein the compound is further defined as: [Image disponible dans le document PDF, Image available in the PDF document] . < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00120"> <pat:ClaimNumber>120< / pat:ClaimNumber> <pat:ClaimText>120. A method of making a compound according to any one of claims 1-72, comprising reacting (a) with (b) in the presence of a coupling agent: (a) a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] (XXXIII), wherein: n is 0, 1, or 2; <semantics>Y1<annotation encoding="application / x-tex">Y_1< / annotation>< / semantics> is <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>-<semantics>alkanediyl(C≤6)<annotation encoding="application / x-tex">alkanediyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl_{(C \le 6)}< / annotation>< / semantics>-<semantics>C(O)R17<annotation encoding="application / x-tex">C(O)R_{17}< / annotation>< / semantics>, or a substituted version of any of these groups, wherein: <semantics>R17<annotation encoding="application / x-tex">R_{17}< / annotation>< / semantics> is alkyl(C≤6) or substituted alkyl(C≤6); Y2 is hydroxy or mercapto; <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, amido<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylsulfonyl(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is hydrogen, amino, halo, hydroxy, carboxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, cycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, aralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, <semantics>amido(C≤6)<annotation encoding="application / x-tex">amido_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylthio(C≤6)<annotation encoding="application / x-tex">alkylthio_{(C \le 6)}< / annotation>< / semantics>, <semantics>alkylsulfonyl(C≤6)<annotation encoding="application / x-tex">alkylsulfonyl_{(C \le 6)}< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; <semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics> is carboxy, <semantics>−NR11R11′<annotation encoding="application / x-tex">-NR_{11}R_{11}'< / annotation>< / semantics>, or <semantics>−C(O)NR12R12′<annotation encoding="application / x-tex">-C(O)NR_{12}R_{12}'< / annotation>< / semantics>, wherein: <semantics>R11<annotation encoding="application / x-tex">R_{11}< / annotation>< / semantics> and <semantics>R11′<annotation encoding="application / x-tex">R_{11}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), substituted alky<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, acy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>, or substituted acy<semantics>l(C≤6)<annotation encoding="application / x-tex">l_{(C \le 6)}< / annotation>< / semantics>; <semantics>R12<annotation encoding="application / x-tex">R_{12}< / annotation>< / semantics> and <semantics>R12′<annotation encoding="application / x-tex">R_{12}'< / annotation>< / semantics> are each independently hydrogen, alkyl(C≤6), or substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>; <semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>, and <semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics> are each independently absent, hydrogen, halo, alkyl(C≤6), substituted alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, substituted alkoxy<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, aralkoxy<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, substituted aralkoxy(<semantics>C≤12<annotation encoding="application / x-tex">C \le 12< / annotation>< / semantics>), acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>), or substituted acyloxy(<semantics>C≤6<annotation encoding="application / x-tex">C \le 6< / annotation>< / semantics>); <semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics> is <semantics>CR14<annotation encoding="application / x-tex">CR_{14}< / annotation>< / semantics> or N, wherein: <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; or <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> and <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), alkylaminodiyl(C<semantics>≤6<annotation encoding="application / x-tex">\leq 6< / annotation>< / semantics>), or a substituted version of any of these groups; <semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics> is <semantics>CR15<annotation encoding="application / x-tex">CR_{15}< / annotation>< / semantics> or N, wherein: <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> is hydrogen, halo, hydroxy, or alkyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkenyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkynyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, <semantics>alkoxy(C≤6)<annotation encoding="application / x-tex">alkoxy(C \le 6)< / annotation>< / semantics>, <semantics>alkylamino(C≤6)<annotation encoding="application / x-tex">alkylamino(C \le 6)< / annotation>< / semantics>, <semantics>−alkanediyl(C≤6)<annotation encoding="application / x-tex">-alkanediyl(C \le 6)< / annotation>< / semantics>-heterocycloalkyl(C \le 8), or a substituted version of any of these groups; <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R14<annotation encoding="application / x-tex">R_{14}< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkenediyl(C≤6), alkoxydiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; or <semantics>R15<annotation encoding="application / x-tex">R_{15}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> are taken together and are alkanediyl(C≤6), alkoxydiyl(C≤6), alkylaminodiyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>, or a substituted version of any of these groups; (b) a compound of the formula: [Image disponible dans le document PDF, Image available in the PDF document] wherein: n is 0, 1, or 2; <semantics>Y3<annotation encoding="application / x-tex">Y_3< / annotation>< / semantics> is hydroxy, halo, <semantics>acyloxy(C≤8)<annotation encoding="application / x-tex">acyloxy(C \le 8)< / annotation>< / semantics>, iminooxy(<semantics>C≤8<annotation encoding="application / x-tex">C \le 8< / annotation>< / semantics>), or a substituted version of either of these groups; <semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics> is carboxy or alky<semantics>l(C≤8)<annotation encoding="application / x-tex">l_{(C \leq 8)}< / annotation>< / semantics>, alkenyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), alkynyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), cycloalkyl(C<semantics>≤8<annotation encoding="application / x-tex">\leq 8< / annotation>< / semantics>), heterocycloalkyl<semantics>(C≤8)<annotation encoding="application / x-tex">(C \le 8)< / annotation>< / semantics>, aryl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, heteroary<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, aralky<semantics>l(C≤12)<annotation encoding="application / x-tex">l_{(C \le 12)}< / annotation>< / semantics>, heteroaralkyl<semantics>(C≤12)<annotation encoding="application / x-tex">(C \le 12)< / annotation>< / semantics>, -alkanediyl<semantics>(C≤6)<annotation encoding="application / x-tex">(C \le 6)< / annotation>< / semantics>-OR13, or a substituted version of any of these groups wherein: <semantics>R13<annotation encoding="application / x-tex">R_{13}< / annotation>< / semantics> is aralkyl(C≤12) or substituted aralkyl(C≤12); R7′ is hydrogen; and <semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>, <semantics>R9<annotation encoding="application / x-tex">R_9< / annotation>< / semantics>, and <semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics> are each independently hydrogen, hydroxy, or alkyl(C≤6), alkoxy(C≤6), <semantics>acyl(C≤6)<annotation encoding="application / x-tex">acyl_{(C \le 6)}< / annotation>< / semantics>, <semantics>acyloxy(C≤6)<annotation encoding="application / x-tex">acyloxy_{(C \le 6)}< / annotation>< / semantics>, <semantics>aralkyl(C≤12)<annotation encoding="application / x-tex">aralkyl_{(C \le 12)}< / annotation>< / semantics>, <semantics>aralkoxy(C≤12)<annotation encoding="application / x-tex">aralkoxy_{(C \le 12)}< / annotation>< / semantics>, or a substituted version of any of these groups. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00121"> <pat:ClaimNumber>121< / pat:ClaimNumber> <pat:ClaimText>121. The method of claim 120, wherein the coupling agent is a Lewis acid. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00122"> <pat:ClaimNumber>122< / pat:ClaimNumber> <pat:ClaimText>122. The method of claim 121, wherein the Lewis acid comprises a boron reagent. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00123"> <pat:ClaimNumber>123< / pat:ClaimNumber> <pat:ClaimText>123. The method of claim 122, wherein the boron reagent is BF3. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00124"> <pat:ClaimNumber>124< / pat:ClaimNumber> <pat:ClaimText>124. The method of claim 122, wherein the Lewis acid is BF3·Et2O. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00125"> <pat:ClaimNumber>125< / pat:ClaimNumber> <pat:ClaimText>125. The method according to any one of claims 120-124, wherein the method further comprises a solvent. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00126"> <pat:ClaimNumber>126< / pat:ClaimNumber> <pat:ClaimText>126. The method according to any one of claims 120-124, wherein the method does not comprise a solvent. < / pat:ClaimText> < / pat:Claim> < / pat:Claims>