Viral particles with enhanced entry into tumor cells

Abstract

The invention relates to a viral particle comprising a mutated glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) and / or a nucleic acid encoding the GP, wherein the viral particle has an enhanced ability to enter a tumor cell. The invention also relates to the mutated GP, the nucleic acid molecules encoding the GP, host cells comprising the nucleic acid molecule or a cDNA from the viral particle genome, the method of producing the viral particle, and its medical applications.