Methods for regulating the production of adeno-associated viruses.
CL202600945A1Pending Publication Date: 2026-07-17SPARK THERAPEUTICS INC
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Patent Information
- Application Number
- CL202600945
- Authority / Receiving Office
- CL · CL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-06-10
- Filing Date
- 2026-03-27
- Publication Date
- 2026-07-17
Abstract
The subject matter described herein relates to compositions and methods for regulating the production of recombinant adeno-associated virus (rAAV) in cell culture. In particular, the subject matter described herein relates to strategies for overcoming AAV Rep protein-mediated cytotoxicity by means of reversible post-translational regulation of AAV Rep and helper protein expression, resulting in regulated rAAV production.
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