Method for synthesizing polypeptides

Abstract

The present invention relates to a method for synthesizing a polypeptide based on solid-phase peptide synthesis, the polypeptide comprising a backbone, the backbone comprising an amino acid residue Δ selected from diaminoalkanoic acids comprising 3 to 10 carbon atoms and a peptide side chain covalently linked to the amino acid residue Δ, the amino acid residue Δ being coupled to an amino acid residue W of the backbone, the method comprising at least one reaction cycle comprising providing an amino acid building block, activating the amino acid building block in the absence of a solid phase at a defined temperature and time period, and coupling the amino acid building block to the backbone.