Carbamoyl lipid with cyclic group in side chain, lipid nanoparticle and pharmaceutical composition

Abstract

Objective: One of the objectives of the invention is to provide a carbamoyl lipid with a cyclic group in a side chain, a lipid nanoparticle containing the lipid, and a pharmaceutical composition thereof. Solution: The present inventors have discovered a carbamoyl lipid with a cyclic group in a side chain capable of forming a lipid nanoparticle and have clarified that a lipid nanoparticle containing the carbamoyl lipid with a cyclic group in a side chain of the invention as a component can express a protein in an astrocyte or hepatocyte. Furthermore, a lipid nanoparticle containing the carbamoyl lipid with a cyclic group in a side chain of the invention as a component should be a component of a pharmaceutical composition that encapsulates a nucleic acid and is useful for the prevention and / or treatment of an astrocyte-related disease.