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Composite support material, composite support, and its production process

A composite scaffold and production method technology, applied in the field of medical engineering, can solve the problems of large fragments, high hardness, and difficult degradation

Active Publication Date: 2008-03-05
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its high hardness, nickel-titanium alloy is easy to wear the pipe wall, and it is not easy to degrade in the body. When the pipe is taken out after returning to normal, the patient will suffer one more pain, so it is not suitable for use as a stent material for urethral and biliary strictures.
Degradable polymer materials solve this problem, but degradable polymers will become brittle in the later stage of degradation, forming larger fragments, which are easy to block pores (Gastointestinal Endoscopy, 2001; 3: 120)

Method used

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  • Composite support material, composite support, and its production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 prepares support (polylactide (100,000) / nylon)

[0019] 1. Nylon wire with a diameter of 0.001mm is woven into a mesh;

[0020] 2. Dissolve polylactide (molecular weight: 100,000) in dichloromethane to form a solution with a mass volume concentration of 0.000001g / ml, and stir evenly;

[0021] 3. The net in step 1 is laid on the bottom of the mold, and the solution in step 2 is poured into the mold. Let the solution evaporate to form a film with a thickness of 0.1. Cut the film into strips with a width of 6mm;

[0022] 4. Wind the strips in step 2 into a spiral shape on the mold, and set the shape at 35° C. for 48 hours to make a spiral stent.

Embodiment 2

[0023] Embodiment 2 prepares support (silk fibroin / silicone rubber)

[0024] 1. Dissolve silk fibroin material in water, prepare a 5g / ml solution, and stir evenly;

[0025] 2. Spread the silicone rubber wire with a diameter of 0.02mm on the bottom of the mold, and pour the solution into the mold. Let the solution evaporate to form a film with a thickness of 2mm. Cut the film into strips with a width of 0.1mm;

[0026] 3. Wind the strips in step 2 into a spiral shape on the mold, and set the shape at 50° C. for 1 hour to make a spiral stent.

Embodiment 3

[0027] Example 3 Preparation of scaffold (polydioxane (100,000) / polydioxane (500,000))

[0028] 1. Polydioxane (molecular weight: 500,000) is made into filaments with a diameter of 0.1mm.

[0029] 2. Polydioxane (molecular weight: 100,000) was dissolved in dichloromethane to form a solution with a mass volume concentration of 2 g / ml, and stirred evenly;

[0030] 3. Pour the solution into the mold, and after 12 hours of volatilization, put the silk in step 1 into the mold. Allow the solution to evaporate completely to form a film with a thickness of 1.5 mm. Cut the film into strips with a width of 0.8mm;

[0031] 4. Wrap the strip in step 3 into a spiral shape on the mold, and set it at 80° C. for 28 hours to make a spiral stent.

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Abstract

A composite scaffold material is prepared from the high-molecular materials with different degradable speeds or the degradable and under-gradable high-molecular materials. A composite scaffold is composed of filarious or reticular skeleton made of the under-gradable or slow-degradable high-molecular materials and the attached layer made of degradable or fast-degradable high-molecular material. Its preparing process includes such steps as slitting said material, winding on die to become spiral shape, and fixating the shape at 20-80 deg. C for 0.1-48 hr.

Description

technical field [0001] The invention relates to the technical field of medical engineering, in particular to a biomedical composite material. Background technique [0002] In clinical practice, cases of ductal stenosis in humans are frequently encountered. Such as urethral stricture, biliary stricture and so on. Urethral stricture is a fairly common histological abnormality in men, often secondary to infectious disease or injury of the urethra. The pathogens of urinary tract infection can spread to the prostate at the same time, causing inflammation of the prostate; due to the fibrotic urethral stricture formed after urethral injury, it can lead to dysuria and urine reflux. Biliary stricture is a biliary complication, and biliary infection can also cause biliary stricture. The current treatment methods mainly contain (1) non-surgical treatment. Non-surgical treatment mainly depends on the expansion of the pipeline, and a stent is placed in the narrow section to keep the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/14A61L27/50A61L31/04A61L31/12A61L31/14A61F2/04A61B17/00A61M29/00
Inventor 崔菡孟波
Owner BEIJING ALLGENS MEDICAL SCI & TECH