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Medicine for treating diabetes and production method thereof

A technology for diabetes drugs and production methods, applied in drug combinations, medical formulas, metabolic diseases, etc., can solve the problems of lack of scientific quality standards, difficulty in determining active ingredients, lack of modernization of traditional Chinese medicine, etc., to achieve rich drug sources and simplified prescriptions , the effect of treating and preventing diabetes

Inactive Publication Date: 2008-07-09
华启洪 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are quite a variety of prescriptions and Chinese patent medicines for treating diabetes with traditional Chinese medicine, but the curative effect is not ideal. The main problem is that the traditional Chinese medicine lacks modernization, it is difficult to determine the active ingredients in the compound prescription, the quality standard is not scientific, and the curative effect is unstable.

Method used

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  • Medicine for treating diabetes and production method thereof
  • Medicine for treating diabetes and production method thereof
  • Medicine for treating diabetes and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0029] The extraction of embodiment 1.1 corn silk total saponins:

[0030] Weigh the dry product of Chinese herbal corn silk to make regular decoction pieces, use 10-14 times the amount of 60-95% ethanol to reflux extract 2-3 times; or decoct the extract with water, decoct 3 times with 10-12 times the amount , one hour each time, the extract is precipitated with 60-95% ethanol, the supernatant is decolorized with 2% medicinal activated carbon, filtered, and the ethanol is recovered until there is no alcohol smell, then extracted 2-3 times with water-saturated n-butanol, and the Recover n-butanol under pressure, and dry the concentrate to obtain total saponins from corn silk. Take a small amount of total saponins, and use Libermann-Burcherd color reaction to carry out identification test: a purple-red reaction occurs between chloroform and the color developer, indicating that the substance is a triterpene saponin. Visible-ultraviolet spectrophotometer was used to measure ginse...

Embodiment 12

[0031] The alcohol extraction method of embodiment 1.2 corn silk total saponins is extracted:

[0032] Choose fresh dry corn silk, process and cut it, 3-5cm long, use 70% ethanol, the ratio of solid to liquid is 1:12, soak for 2 hours, put it into the extraction cylinder of Soxhlet extractor, and reflux extraction twice, For 1.5 hours each time, combine two alcohol extracts, high-speed centrifugation, 3000-3500r / min, 15', take the supernatant, distill under reduced pressure, recover ethanol, the specific gravity of the concentrated solution is 1.10-1.25g / cm at 50°C 3 , and then extracted with water-saturated n-butanol, a total of 3 extractions, collected the n-butanol layer, distilled under reduced pressure, recovered n-butanol, and placed the concentrated solution in a vacuum drying oven at a temperature of 60°C and a vacuum pressure of 0.08-0.1mpa , and vacuum-dried to obtain a dry thick paste, which is the total saponins of corn silk.

[0033] Select the four factors of et...

Embodiment 13

[0034] The alcohol extraction method of embodiment 1.3 corn silk total saponins is extracted:

[0035] Choose fresh dried corn silk, after cutting, weigh 250kg, put it into a multi-functional extraction tank, use 70% ethanol, which is 11-12 times the weight of the medicinal material, soak for 2 hours, and carry out reflux extraction at a temperature of 50°C in the tank , a total of 2 extractions, each time 2h. The ethanol extract is concentrated by an external heating circulation concentrator, the ethanol is recovered, and concentrated to a specific gravity of 1.08-1.15g / cm at 50°C 3 , extracted with water-saturated n-butanol, extracted twice, n-butanol extract was distilled under reduced pressure, n-butanol was recovered, the concentrated solution was put into a vacuum desiccator, the vacuum pressure was 0.08-0.09mpa, the temperature was 60°C, and dried. The yellowish-brown powdery dry product is the total saponins of corn silk. The method is especially suitable for industr...

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Abstract

The invention provides a Chinese traditional medicine for treating diabetes, wherein the active compounds can include corn stigma saponins, or corn stigma flavones, the preferred weight ratio of the corn stigma saponins and corn stigma flavones is between 1:1.5-1:0.001, the optimum proportion ratio range is 1:1 - 1:0.1. The active compound can also include corn stigma crude polysaccharides, wherein the preferred weight ratio of the corn stigma saponins and corn stigma crude polysaccharides is between 1:1.5-1:0.001, the optimum proportion ratio range is 1:1 - 1:0.1. The active compound can also include corn stigma saponins, corn stigma flavones and corn stigma crude polysaccharides.

Description

technical field [0001] The invention relates to a medicine for treating diabetes in the field of traditional Chinese medicine. The invention also relates to a preparation method of the medicine. Background technique [0002] Diabetes is a group of systemic endocrine and metabolic diseases. Its pathophysiological changes are relative or absolute insufficiency of insulin secretion, which causes sugar, fat, protein and secondary vitamin, water and electrolyte metabolic disorders, resulting in hyperglycemia, hyperlipidemia and blood Viscosity increases, and extensive microvascular lesions all over the body appear in the middle and late stages, manifested as elevated blood sugar and urine sugar, and patients manifest symptoms such as polydipsia, polyphagia, polyuria, dry mouth, and general weakness. It is a type of disease that is currently difficult to cure . [0003] Diabetes morbidity and mortality are high. The incidence rate of the population is 1%-5%, and the incidence r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/10A61K131/00
Inventor 华启洪周大春华巍巍孙静
Owner 华启洪