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Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency

A technology of insufficient cerebral blood supply and composition, which is applied in the field of medicine and can solve the problems of lack of focal neurological signs in the brain and the like

Active Publication Date: 2008-08-20
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] 3. No focal neurological signs of the brain;
[0025] 4. CT\MRI without vascular organic brain changes;
So far, no reports have been found on the treatment of chronic cerebral insufficiency with Yangxue Xuenao Granules

Method used

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  • Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency
  • Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency
  • Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] (1) Take 80g of Angelica, 80g of Chuanxiong, 80g of Paeoniae Alba, 80g of Rehmannia Rehmanniae, 120g of Uncle Teng, 120g of Spatholobus, 120g of Prunella vulgaris, 120g of Cassia Seed, 120g of Mother of Pearl, 70g of Rhizoma Rhizoma Rhizoma, 10g of Asarum;

[0072] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%, and the clear paste, sucrose and dextrin are taken to make 200 tablets in a ratio of 1:3:1.

Embodiment 2

[0074] (1) Take 67.5g of Angelica, 67.5g of Chuanxiong, 54g of Radix Paeoniae Alba, 54g of Rehmannia Rehmanniae, 135g of Spatholobus Spatholobus, 135g of Prunella vulgaris, 135g of Cassia Seed, 135g of Mother of Pearl, 67.5g of Rhizoma Rhizoma Rhizoma, 14.5g of Asarum;

[0075] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%. Take the clear paste, sucrose and dextrin in a ratio of 1:3:1 to make 125 bags of granules.

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Abstract

The present invention belongs to the field of medicine technology, and is especially the new use of one kind of medicine composition in preparing medicine. The present invention establishes chronic brain blood supply deficiency rat model via tying common carotid artery on two sides and administrates the medicine composition through stomach perfusion. The test result shows that the medicine composition results in learning and memory function and dizziness latent phase of the rat obviously prior to the contrast group (P<0.05).

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for treating chronic cerebral insufficiency. Background technique [0002] The origin of the concept [0003] Chronic Cerebral Circulation Inefficiency (CCCI) refers to the state of reduced blood supply to the brain at the overall level (less than 40-60ml / 100g brain tissue / minute), rather than focal cerebral ischemia. It is a relatively new disease name proposed by foreign countries in the first 10 years. Clinically, some elderly or pre-senile patients who repeatedly complain of subjective symptoms such as heavy head and dizziness have neither focal signs of nerve damage nor brain CT abnormalities except fundus arteriosclerosis. Arteriosclerosis". It is well known that the concept and clinical diagnostic criteria of cerebral arteriosclerosis have been divergent for a long time. In order to avo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61P9/10
Inventor 吴廼峰蔡定芳顾喜喜陈依萍戴巍闻名范越
Owner TIANJIN TASLY PHARMA CO LTD
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