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Multiple laminar flow-based particle and cellular separation with laser steering

A technology of cells and blood cells, which is applied in the field of separating particles or materials, and can solve problems such as complex optical systems

Inactive Publication Date: 2009-04-08
ABS GLOBAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One problem with this technique is that the optics become progressively more complex as the number of traps increases
Because of these issues, implementations of this method are known to be limited to less than about 5 traps per system

Method used

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  • Multiple laminar flow-based particle and cellular separation with laser steering
  • Multiple laminar flow-based particle and cellular separation with laser steering
  • Multiple laminar flow-based particle and cellular separation with laser steering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0086] specific implementation plan

[0087] While the invention is susceptible to embodiments in many different forms, the specific embodiments shown in the drawings and described in detail herein are to be construed as being illustrative of the principles of the invention and not limiting the invention to the Examples of which are specifically set forth.

[0088] As described above, various embodiments of the present invention are used to separate components of mixtures, such as separating different blood components in whole blood into corresponding fractions, such as platelet fractionation, red blood cell fractionation, leukocyte fractionation, and plasma fractionation. These various embodiments utilize one or more sieving channels with multiple steady laminar flows and allow one or more components to differentially settle from one stream into the other, thereby separating the components as described below become the corresponding liquid flow. Alternatively, these differe...

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PUM

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Abstract

Here is a device (100) for separating fluid multi components (A, B, C, D). The device is comprised of an optically transparent screen separation channel (110), the first import (120) for the first fluid flow (W), the second import (120) for the second fluid flow (X), the first export (130) for the first fluid flow (W), the second export (130) for the second fluid flow (X), holographic optical trap system (210) joint to optically transparent screen separation channel (210). Wherein the first component A of the multi components (A, B, C, D) in the first fluid flow (W) can be selectively transferred to the second fluid flow (X) and engender enriched the second fluid flow (X).

Description

technical field [0001] The present invention relates generally to techniques and systems for separating particles or materials, such as blood, sperm, and other particles and cells, into their different components and separations using multilayer flow and further combined with laser manipulation , for example in combination with holographic optical trapping and manipulation. Background technique [0002] There are several classifications of blood cells. The amount of red blood cells or erythrocytes (RBC) is 4.8 million cells / μl for women and 5.4 million cells / μl for men. RBCs make up 93% of the solid component of blood and occupy about 42% of the blood volume. Platelets are 2μm-3μm in size, they make up 7% of the solid content of blood and account for about 3% of blood volume, equivalent to about 1.5 to 4×10 per liter 11 cells. There are 5 regular types of white blood cells (WBCs) or leukocytes in numbers of about 1.5 to 4 x 10 per liter 9 cells. WBCs include 50-70% neu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D61/00
Inventor 埃米·安迪生刘易斯·格鲁伯丹·米特约瑟夫·普莱瓦杰西卡·沙伊尔曼尼尔·哈里斯·罗森鲍姆
Owner ABS GLOBAL