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Dithranol stick

A technology of dithranol wax stick and dithranol, which is applied in the direction of non-active ingredients of oil/fat/wax, organic active ingredients, skin diseases, etc., and can solve the problems of low-concentration preparations that are not as effective and patients cannot tolerate them

Inactive Publication Date: 2009-06-10
孙勐 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the treatment of psoriasis with dithranol preparations, the method of gradually increasing the concentration of dithranol should be adopted in principle. Patients often cannot tolerate high-concentration preparations at the beginning, but the curative effect of low-concentration preparations is not as good as that of high-concentration preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] (1) Dithranol wax stick (6.5g: 32.5mg) 1000 sticks

[0093]

[0094] preparation:

[0095] (1) Mix the waxes together and melt them;

[0096] (2) Dithranol and salicylic acid plus an appropriate amount of castor oil are ground and mixed;

[0097] (3) Mix (1) and (2), pour into a mold, and cool down.

Embodiment 2

[0099] (2) Dithranol wax stick (6.5g: 65mg) 1000 sticks

[0100]

[0101]

[0102] preparation:

[0103] (1) Mix the waxes together and melt them;

[0104] (2) Dithranol and salicylic acid plus an appropriate amount of castor oil are ground and mixed;

[0105] (3) Mix (1) and (2), pour into a mold, and cool down.

Embodiment 3

[0107]

[0108] Method is the same as embodiment 1

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Abstract

The present invention relates to one new medicine form of dithranol, and is especially wax rod preparation with dithranol as the active component and comprising dithranol, wax, salicylic acid and castor oil.

Description

technical field [0001] The invention relates to a new pharmaceutical dosage form of dithranol, in particular to a wax stick preparation with dithranol as an active ingredient. Background technique [0002] Dithranol has been used for a long time in the treatment of psoriasis with definite curative effect. Since the 1970s, although there have been new anti-psoriasis drugs coming out, dithranol is still one of the first-selected drugs for the treatment of psoriasis. It is the most effective and commonly used drug for external treatment of psoriasis. It is widely used in Europe and the United States, especially for the intractable skin lesions of psoriasis. It is the standard therapy for plaque psoriasis. Judging from the current situation and level of external therapy for psoriasis at home and abroad, corticosteroids, vitamin D3 analogues (such as calcipotriol), dithranol and tar preparations are more popular. [0003] Dithranol, its chemical name is: 1,8-2 hydroxy-9-anthron...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K9/00A61K47/44A61K31/60A61P17/06A61K47/06
Inventor 史雪燕董文哲
Owner 孙勐
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