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Use of patchouli alcohol in preparing medicament for preventing and controlling senile dementia

A patchouli alcohol, senile technology, applied in the field of medicine, to achieve huge social and economic benefits, and the effect of significant curative effect

Inactive Publication Date: 2010-01-13
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently marketed drugs for the treatment of senile dementia, such as Aricept and Tacrine, can improve or alleviate the symptoms of dementia in mild patients to a certain extent, but cannot prevent or reverse the further development of lesions

Method used

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  • Use of patchouli alcohol in preparing medicament for preventing and controlling senile dementia
  • Use of patchouli alcohol in preparing medicament for preventing and controlling senile dementia
  • Use of patchouli alcohol in preparing medicament for preventing and controlling senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Anti-apoptosis effect of bucchini alcohol

[0018] 1. Materials

[0019] 1. Baiqiu Li alcohol, purchased from China Institute for the Control of Pharmaceutical and Biological Products, with a purity of over 98%.

[0020] 2. Aβ 25～35 , purchased from Sigma Company.

[0021] 3. Annexin V-FITC, FITC-labeled annexin V, was purchased from Jingmei Bioengineering Co., Ltd.

[0022] 4. PI solution, propidium iodide solution.

[0023] 5. Rat pheochromocytoma cell (PC12) cell line, passaged and preserved in our laboratory.

[0024] 2. Method

[0025] Anti-Aβ effect of buccal alcohol detected by flow cytometry 25～35 Causes apoptosis in rat pheochromocytoma cells (PC12). The experimental groups were as follows: control group; Aβ 25～35 Treatment group; different doses of drug groups.

[0026] Take 100 μl of cell suspension in a flow tube, add 5 μl Annexin V-FITC and 10 μl PI solution (20 μg / ml) and mix well, incubate at room temperature in the dark for 15 minutes...

Embodiment 2

[0032] Example 2: Buocchiol promotes axonal growth of primary cultured hippocampal neurons

[0033] 1. Materials

[0034] 1. Baiqiu Li alcohol, purchased from China Institute for the Control of Pharmaceutical and Biological Products, with a purity of over 98%.

[0035] 2. Trypsin, the concentration is 0.25%, purchased from Sigma company

[0036] 3. DMEM / F-12 medium, purchased from Gibco.

[0037] 4. Nerve growth factor (NGF), purchased from Beijing Shengri Pharmaceutical Technology Development Co., Ltd.

[0038] 5. Fetal bovine serum, purchased from Gibco.

[0039] 6. N2, purchased from Gibco.

[0040] 7. B27, purchased from Gibco.

[0041] 8. Cytarabine, purchased from Harbin Bolai Pharmaceutical Co., Ltd.

[0042] 9. SD rat suckling mice, within 12 hours after birth, were given both ♀♂ and divided into control group and drug groups with different doses, purchased from the Experimental Animal Center of Academy of Military Medical Sciences.

[0043] 2. Method

[0044] ...

Embodiment 3

[0050] Example 3: The promoting effect of bocicol on the learning and memory of senile dementia model mice

[0051] 1. Materials

[0052] 1. Baiqiu Li alcohol, purchased from China Institute for the Control of Pharmaceutical and Biological Products, with a purity of over 98%.

[0053] 2. Scopolamine, produced by Xuzhou Lane Pharmaceutical Co., Ltd.

[0054]3. Kunming mice, weighing 14-16g, female, were divided into normal control group, scopolamine group and drug groups with different doses. The mice were randomly divided into groups according to the principle of weight balance, with 10 mice in each group. They were purchased from the Experimental Animal Center of Academy of Military Medical Sciences .

[0055] 2. Method

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Abstract

The invention discloses the usage of patchouli alcohol in the process of preparing medicament for preventing and curing senile dementia, belonging to the medical field. The invention has the advantages that the invention is extensively and deeply researched, patchouli alcohol is unexpectedly found to have the functions of neural protection and nutrition in the process of screening medicament which is anti senile dementia. Further study finds that patchouli alcohol has a promoting effect to the study and memory of a senile dementia mould mouse. Thereby patchouli alcohol can be used to prepare a medicament which can prevent and cure senile dementia. The medicament which utilizes patchouli alcohol to be active component may have significant effects in clinic, thereby bringing out large social and economic benefits.

Description

technical field [0001] The invention relates to the use of bocicol in the preparation of medicaments for preventing and treating senile dementia, and belongs to the field of medicine. Background technique [0002] Patchouli, Pogostemon cablin (Blanco) Benth, is a plant of the Lamiaceae Patchouli genus, a perennial herb, and the whole herb is used for medicine. Its taste is pungent, slightly warm, and it returns to the three meridians of spleen, stomach, and lung. The medicinal ingredients of patchouli are mainly its volatile oil, which is called patchouli oil, which has the functions of regulating digestive tract function, relieving spasm of gastrointestinal smooth muscle and antibacterial effect. Its main component is patchouli alcohol (patchoulialcohol, pothole alcohol), which has calcium ion antagonistic effect (Chem Pharm Bull, 1989, 37(2): 345-348). Patchouli alcohol is a tricyclic sesquiterpene compound, crystallizable, melting point 55-56%, boiling point 140°C (1.06...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61K9/00A61K9/127A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 黄晓舞栾复新徐风华
Owner GENERAL HOSPITAL OF PLA