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Medicinal composition for preventing alcoholic liver damage

A liver injury and composition technology, applied in the field of medicine or health food of milk thistle-red yeast composition, can solve the problems of alcoholic liver disease patients' acceptance, poor curative effect, adverse reactions, etc., to reduce total cholesterol, reduce LDL cholesterol, significant curative effect

Inactive Publication Date: 2010-02-24
张帆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, drugs to quit alcohol dependence are still being searched for. The current drugs have proven to be ineffective or have potential toxicity in Linchuan. For most alcoholics, long-term nutritional support treatment programs are unacceptable. At present, most patients with severe hepatitis , hepatic coma or patients with severe malnutrition
Non-specific anti-inflammatory quality currently mostly uses glucocorticoids, long-term use has serious adverse reactions, it is difficult to accept a large number of patients with mild and moderate alcoholic liver disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1, preparation of milk thistle-monascus composition tablet

[0046] Prescription composition:

[0047] Silymarin 55g

[0048] Red yeast rice 273.0g

[0049] Microcrystalline Cellulose 38g

[0050] Micronized silica gel 12g

[0051] Stearic acid 18g

[0052] Lactose 11g

[0053] Magnesium Stearate 1g

[0054]

[0055] Makes 1000 pieces

[0056] Preparation method: Take red yeast rice, crush it through a 100-mesh sieve, mix it with micronized silymarin, add the other excipients in the prescription: microcrystalline cellulose, micropowder silica gel, stearic acid and lactose, mix well, and make granules. After drying, add magnesium stearate, mix well, and press into tablets to obtain the product.

Embodiment 2

[0057] Embodiment two, milk thistle-monascus composition capsule preparation

[0058] Prescription composition:

[0059] Sufibin Phospholipid Complex (4 / 1) 20g

[0060] Red yeast rice 280.0g

[0061] 25g pregelatinized starch

[0062] Micronized silica gel 8g

[0063]

[0064] Makes 1000 capsules

[0065] Preparation method: Take silibinin, add 5g of phospholipid, dissolve with ethanol, filter, evaporate to dryness, and dry to obtain silibinin phospholipid complex; take red yeast rice, crush it through a 100-mesh sieve, and mix with silibinin phospholipid complex Evenly, add disintegrating agent pregelatinized starch, mix evenly, and finally mix with micronized silica gel, put into No. 2 capsule shell, and obtain.

Embodiment 3

[0066] Example 3, Preparation of Milk Thistle-Red Yeast Composition Dispersible Tablets

[0067] Prescription composition:

[0068] Milk thistle flavonoid extract (micronized) 200g (contains 20% silybin)

[0069] Monascus ethanol extract (micronized) 20.0g

[0070] Lactose 50g

[0071] CMS-Na 25g

[0072] Microcrystalline Cellulose 50g

[0073] L-HPC 25g

[0074] 5% PVP K30 appropriate amount

[0075] Magnesium Stearate 3g

[0076]

[0077] Makes 1000 pieces

[0078] Preparation method: According to the above prescription, take the main drug after micronization treatment, add microcrystalline cellulose, L-HPC, cross-linked CMC-Na, and 1 / 3 of the prescription amount of CMS-Na into a wet mixing granulator, Mix for 2 minutes, add binder (5% PVP K30 alcohol solution), granulate with a 30-mesh sieve, and dry at 50-80°C; dry granules pass through a 20-mesh sieve for granulation, add magnesium stearate and micropowder silica ...

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PUM

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Abstract

A composition used to prepare the medicine or health-care food for relaxing fatty liver and alcoholic liver injury is prepared from silybuflavone and red koji.

Description

technical field [0001] The invention relates to a medicament or a health food of a milk thistle-monascus composition, which can effectively alleviate the symptoms of liver diseases such as fatty liver and alcoholic liver injury, as well as the pathological changes of the liver, and delay the development of the disease. Background technique [0002] Alcohol abuse and alcohol dependence have become increasingly serious public health problems in the world. In 2001, my country's alcohol production reached 30.6987 million tons. An epidemiological survey of the drinking situation in my country's four major drinking areas shows that the drinking rate of the general population is 59.5%. , of which 84.6% are men and 29.4% are women, and the per capita annual alcohol consumption is equivalent to 3.6 liters of ethanol. [0003] Alcohol has obvious toxic effects on the liver. More than 80% of heavy alcohol drinkers have a certain degree of fatty liver, 10% to 35% can develop into alcohol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K36/06A61K9/20A61K9/48A61K9/16A61K9/08A61K9/10A61P25/32A61P1/16A23L1/30
Inventor 张帆
Owner 张帆