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Medicine compound for treating snoring and the preparing method and detection method

A composition and drug technology, applied in the direction of drug combination, testing of pharmaceutical preparations, pharmaceutical formulations, etc., can solve problems such as inconvenient portability, poor repeatability, and inability to cure permanently

Active Publication Date: 2010-06-09
浙江宝仁堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgical operations have certain surgical indications and poor repeatability after recurrence; device therapy has the problems of inconvenient to carry and cannot be permanently cured
and both are expensive

Method used

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  • Medicine compound for treating snoring and the preparing method and detection method
  • Medicine compound for treating snoring and the preparing method and detection method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0100] Effect of Experimental Example 1 on Xylene-Induced Auricle Swelling of Mice

[0101] The mice were randomly divided into 5 groups, i.e. the control group, the pharmaceutical composition capsule 11.1, 5.55, 2.78 g / kg group and the dexamethasone 2 mg / kg group. The control group was given the same amount of drinking water for four consecutive times, once a day. One hour after the last administration, apply about 0.05ml of xylene on both sides of the right ear of the mouse to cause swelling, and the left ear is regarded as a normal ear without application. After 30 minutes, the rats were sacrificed by dislocation of the cervical spine, and the discs of the same parts of the left and right ears were punched out with a 7.5mm punch, weighed on an analytical balance, and the swelling rate was calculated. Swelling rate=(right ear piece weight-left ear piece weight) / left ear piece weight×100%, the results are shown in Table 1.

[0102] Table 1 Effects of Drugs on Mouse Auricle ...

experiment example 2

[0106] Effect of Experimental Example 2 on Cotton Ball Granuloma

[0107] The rats were randomly divided into five groups, namely the control group, the dexamethasone 1mg / kg group, the pharmaceutical composition concentrated pill 5.55g / kg group, the 2.78g / kg group, and the 1.39g / kg group. Intragastric administration, once a day, for 10 consecutive days, the control group was given drinking water of the same amount (1ml / 100g body weight); the animal was anesthetized with chloral hydrate (350mg / kg), an opening was made in the middle of the abdomen, and hemostatic forceps were used to anesthetize the animal. Peel off the skin to the groin, implant a 50 mg cotton ball pre-autoclaved and added 0.1ml of gentamicin into the groin, suture the skin, and start the administration after the animal wakes up; 1 hour after the last administration, the animal was sacrificed by breaking the vertebrae. For rats, the abdominal skin was opened, the cotton balls were carefully peeled off, and weighe...

Embodiment 1

[0114] Panax notoginseng 30kg, ramie root 30kg, Fritillaria 30kg, Cordyceps sinensis 3kg, licorice 9kg, bellflower 20kg

[0115] The pharmaceutical composition is made into concentrated water pills by conventional techniques.

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PUM

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Abstract

The invention discloses a method for preparing a drug compound for treating snoring and a relative quality control method. The drug compound is formed by notoginseng, ramie root, fritillary, Chinese caterpillar fungus, licorice, root of ballon flower, Danshen, chuanxiong rhizome, gen-seng, and curcuma aromatica or the like. And the preparation comprises that breaking the notoginseng, gen-seng andChinese caterpillar fungus into powder, screening, mixing uniformly, adding Danshen and fritillary with alcohol to reflux and extract, combining extractives, filtering and concentrating into paste, adding water into chuanxiong rhizome and curcuma aromatica, distilling and extracting the volatile oil, filtering, concentrating the drug liquid into paste, boiling drug slag, root of ballon flower, ramie root and licorice in water, combining the boiled liquid, filtering, concentrating, radiating heat, adding alcohol, filtering, and recycling the filter liquid, concentrating into paste, drying two pastes, breaking into powder, mixing with the first powders, to obtain mixture powder, adding general findings, to prepare oral solid agent via general method. The clinic test proves the significant snoring treatment effect of inventive drug compound.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a detection method, in particular to a pharmaceutical composition for treating snoring, a preparation method and a detection method. Background technique [0002] The pathogenesis of snoring is complex, and factors such as nerves, muscles, and body fluids are all involved. During sleep, due to the above reasons, soft tissues such as the pharynx and nasopharynx relax and collapse, resulting in narrowing of the airway and snoring. Therefore, snoring can be not only an external pathological manifestation produced by various causes, but also can be used as a source cause of disease, which can cause many diseases secondary to it. If it is not controlled in time, it can cause various diseases such as cardiovascular and cerebrovascular diseases, and even sudden death. Therefore, it has attracted more and more attention from the medical community and society. [0003] At present,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8967A61K36/484A61K36/34A61K36/258A61K36/185A61K36/068G01N30/90G01N33/15A61P11/02A61K35/618A61K35/64
Inventor 吴昊吴洵邦
Owner 浙江宝仁堂药业有限公司