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Chinese traditional medicine composition for treating cholecyst disease and fingerprint pattern analyzing method thereof

A technology of fingerprint spectrum and analysis method, applied in the field of traditional Chinese medicine composition for the treatment of gallbladder disease and the analysis of its fingerprint spectrum, can solve the problem of not really changing the lithogenesis trend of patients and the like

Active Publication Date: 2011-06-29
HEHUANG PHARMA SHANGHAI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Surgical treatment can effectively remove most of the formed stones, but it cannot really change the stone formation trend in patients, and there is a certain proportion of postoperative recurrence

Method used

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  • Chinese traditional medicine composition for treating cholecyst disease and fingerprint pattern analyzing method thereof
  • Chinese traditional medicine composition for treating cholecyst disease and fingerprint pattern analyzing method thereof
  • Chinese traditional medicine composition for treating cholecyst disease and fingerprint pattern analyzing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Main component extraction method in the Chinese medicine composition

[0027] Take the tablet of the traditional Chinese medicine composition, remove the coating, dry at 70°C, grind into a fine powder, accurately weigh about 100mg, put it in a 10ml volumetric flask, add about 8ml of 70% methanol, extract it ultrasonically for 40 minutes, and let it cool to After room temperature, dilute to volume with 70% methanol, mix well, pass through a 0.45 μm microporous membrane, take 20 μl of the filtrate, and inject it into a high-performance liquid chromatograph for determination.

Embodiment 2

[0028] Embodiment 2: main component extraction method in the Chinese medicine composition

[0029] Take the Chinese medicine composition tablet, remove the coating, dry at 70°C, grind into fine powder, accurately weigh about 250 mg, put it in a stoppered Erlenmeyer flask, add 25 ml of 70% methanol accurately, weigh, and extract by reflux for 1 Hours, let cool to room temperature and make up the weight with 70% methanol, mix well and filter with 0.45 μm microporous membrane, take 20 μl of continued filtrate, and inject it into high performance liquid chromatography for determination.

Embodiment 3

[0030] Embodiment 3: Chinese medicine composition fingerprint analysis method

[0031] Using LC-2010AHT liquid chromatograph, the chromatographic column model is Dimonsil C 18 Chromatographic column (250mm×4.6mm, 5μm); Mobile phase is made up of aqueous phase and organic phase, and aqueous phase is the aqueous solution containing 0.05% formic acid (adjusting pH to be 5 with triethylamine), and organic phase is acetonitrile; Elution gradient It is: the proportion of the organic phase increases linearly from 15% to 35% within 40 minutes; The proportion of the phase increases linearly from 50% to 100%, and maintains the 100% ratio for 70 minutes; the detector uses an ultraviolet detector with a detection wavelength of 346nm; the flow rate is 0.8ml per minute; the column temperature is 25°C. The resulting fingerprint spectrum is shown in Figure 2, which contains 20 characteristic peaks.

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Abstract

The invention relates to a compound Chinese medicament for treating gall bladder diseases and process for preparation, wherein the preparation comprises rhubarb horsetails, giant knotweed rhizome, green tangerine orange peel, dried orange peel, curcuma aromatica, haw and cogongrass rhizome or their extracts. The fingerprint pattern of the constituents of the Chinese medicinal composition processes characteristic peaks of a certain amount, the relative holding time and relative peak area of each characteristic peak are confined to a certain proportion.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating gallbladder disease and a fingerprint analysis method thereof. The result obtained by the fingerprint analysis method represents the specific proportion and process of the traditional Chinese medicine composition. Background technique [0002] Cholelithiasis is a common disease. In my country, patients with cholelithiasis account for about 5%-10% of the population, and are increasing year by year. The current treatment methods are mainly divided into two categories: surgical and non-surgical. Surgical treatment can effectively remove most of the formed stones, but it cannot really change the tendency of stone formation in patients, and there is a certain proportion of postoperative recurrence. Instead of surgical treatment of gallstones, a comprehensive treatment system based on traditional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/16G01N30/02G01N30/86
Inventor 徐瑞林丁建弥陈忠樑乐国祥
Owner HEHUANG PHARMA SHANGHAI
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