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Field effect transistor biosensor preparation method

A technology of field-effect transistors and biosensors, applied in the field of biosensors, can solve the problems that large-scale high-quality samples cannot be prepared in large quantities, biosensors and their detection equipment have not yet been seen, and the growth mechanism of carbon nanotubes is complicated. Easy on-line control and detection automation, less sample consumption, small volume effect

Inactive Publication Date: 2010-06-23
董益阳 +1
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  • Application Information

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Problems solved by technology

The production method first grows carbon nanotube arrays on silicon wafers, and then constructs field effect tube biosensors. The sensor constructed by this method has a single detection object, and there are still many problems in the current method of preparing carbon nanotube arrays on chips. The growth mechanism of carbon nanotubes is complex, and the diameter, length, growth direction and inevitable impurities (catalysts, amorphous carbon, etc.) of carbon nanotubes will greatly affect the performance of the device
At the same time, this method cannot prepare large-scale high-quality samples in large quantities, which seriously restricts its properties and application research.
[0006] From the above analysis, it can be seen that there are still many problems in field effect transistor biosensors, and biosensors and detection equipment that are conducive to market promotion have not yet been seen.

Method used

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  • Field effect transistor biosensor preparation method
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  • Field effect transistor biosensor preparation method

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Embodiment Construction

[0034] The technical solution will be described in detail below with examples.

[0035] refer to image 3 , the field effect transistor biosensor of the present invention comprises a base layer and a sealing body. The base layer consists of a silicon wafer 21 and silicon dioxide (SiO2) deposited thereon. 2 ) film layer 22 constitutes. The sealing body 20 is made of polydimethylsiloxane oligomer (PDMS). In other embodiments of the field effect transistor biosensor of the present invention, germanium can also be used as the base layer. The sealing body 20 can also be made of polymethyl methacrylate oligomer (PMMA).

[0036] refer to figure 2 and Figure 4 , in the field effect transistor biosensor of the present invention, the sealing body 20 is provided with S, P, N, B four evenly distributed grooved channels 1 on the joint surface with the base layer, and the four grooved channels 1 are respectively It is used for sample injection detection of the sample to be tested, ...

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Abstract

The utility model provides a field effect transistor biological sensor, comprising a substrate and a sealing body. The sealing body is provided with a plurality of groove type channels, specimen feeding channels and specimen discharge channels, at least one pair of metal electrodes are horizontally arranged in each groove type channel and are respectively used as a source pole and a leak pole of the field-effect transistor. A carbon nanometer tube is arranged between the metal electrodes, the metal electrodes and the carbon nanometer tube are welded together each other. Pins are arranged below the substrate and are connected with the metal electrodes by conductive glue having insulation layer. The utility model also provides a preparation method based on the field-effect transistor and adopts the inspection device of the sensor. The utility model has the advantages that multi objectives can be used for inspection so as to perform high-flux and high sensitivity, enabling compact structure, less sample usage amount, simple process, low cost, suitability for batch production, simple and convenient operation, rapid analysis speed, thus online control and inspection automation.

Description

technical field [0001] The invention relates to a biosensor, in particular to a biosensor, a preparation method thereof and a detection device using the sensor. Background technique [0002] Due to its excellent selectivity and high sensitivity, biosensors have broad application prospects in the fields of clinical, food, biological, and environmental detection. Field-effect transistor biosensor (FET) is a very important branch of sensors. [0003] The field effect tube biosensor is a biological functional film instead of the metal gate electrode of the insulated gate field effect transistor. The potential (or charge) change of the biological functional film and the solution or gas interface is reflected to the current change of the drain, so as to realize the detection. Purpose. With the development of microfabrication technology in recent years, FET biosensors are considered to be an effective means to develop miniature biosensors. [0004] Most of the currently reported...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/414
Inventor 董益阳任冬梅齐小花程艳王军兵王大宁
Owner 董益阳
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