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Polyacrylamide polyurethane urea and method for producing the same

A polyacrylamide and polyurethane technology, applied in medical science, prosthesis and other directions, can solve the problems of low mechanical strength, loss of mechanical properties, difficult processing, etc., and achieve good biocompatibility, good mechanical properties, and simple preparation method. Effect

Active Publication Date: 2012-12-12
吴如舟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these polymers have many disadvantages, including low strength and rapid loss of mechanical properties in vivo, difficult processing, and acidity of degradation products leading to inflammation and tissue necrosis, etc.

Method used

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  • Polyacrylamide polyurethane urea and method for producing the same
  • Polyacrylamide polyurethane urea and method for producing the same
  • Polyacrylamide polyurethane urea and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Add 8.2g (0.11mol) of 1,2-propylenediamine and 20mL of distilled water into a 100mL three-necked flask, connect the stirring device, and place it in a low-temperature thermostat. After the temperature dropped to -5°C, 9.0 g (0.1 mol) of acryloyl chloride and 16 mL of aqueous sodium hydroxide solution (25%, w / w) were slowly added dropwise at the same time. During the dropping process, the temperature is controlled within 0-5°C, and the pH value is kept at 8-9. After the dropwise addition, continue to stir for about 30 min, slowly rise to room temperature for 2 h, then raise the temperature to 50° C. to continue the reaction for 2 h, and stop the reaction. Unreacted 1,2-propylenediamine and water were distilled off under reduced pressure to obtain a brownish-yellow viscous liquid. Add 50 mL of absolute ethanol, stir to dissolve, and filter to remove solid sodium chloride. The filtrate was evaporated to remove absolute ethanol to obtain the crude product of N-(2-amin...

Embodiment 2

[0017] (1) Add 6.6g (0.11mol) of ethylenediamine and 30mL of tetrahydrofuran into a 100mL three-necked flask, connect the stirring device, and put it into a low-temperature thermostat. After the temperature dropped to -5°C, 9.0 g (0.1 mol) of acryloyl chloride and 16 mL of aqueous sodium hydroxide solution (25%, w / w) were slowly added simultaneously. During the dropping process, the temperature was controlled below 0°C, and the pH value was kept at 8-9. After the dropwise addition, continue to stir for about 30 minutes, slowly rise to room temperature for 2 hours, then raise the temperature to 40° C. to continue the reaction for 1 hour, and stop the reaction. Unreacted ethylenediamine, tetrahydrofuran and water were distilled off under reduced pressure to obtain a yellowish viscous liquid. Add 50 mL of absolute ethanol, stir to dissolve, and filter to remove solid sodium chloride. The filtrate was evaporated to remove absolute ethanol to obtain the crude product of N-(2-amin...

Embodiment 3

[0020] (1) Add 24.4g (0.21mol) of 1,6-hexanediamine and 50mL of distilled water into a 250mL three-necked flask, connect the stirring device, and place in a low-temperature thermostat. After the temperature dropped to -5°C, 18.0 g (0.2 mol) of acryloyl chloride and 30 mL of aqueous sodium hydroxide solution (25%, w / w) were slowly added dropwise at the same time. During the dropping process, the temperature is controlled within 0-5°C, and the pH value is kept at 8-9. After the dropwise addition, continue to stir for about 30 min, slowly rise to room temperature for 2 h, then raise the temperature to 50° C. to continue the reaction for 2 h, and stop the reaction. Unreacted substances and water were distilled off under reduced pressure to obtain a brownish-yellow viscous liquid. Add 50 mL of absolute ethanol, stir to dissolve, and filter to remove solid sodium chloride. The filtrate was evaporated to remove absolute ethanol to obtain the crude product of N-(6-aminohexyl)-acryla...

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Abstract

The invention discloses polyacrylamide / urea with netted texture and a preparation method and use thereof. The polymer with netted texture is formed by connecting the polyacrylamide with a linear structure and the ramification by using aliphatics diisocyanate as coupling agent and has good biocompatibility and mechanical property, and the invention can be used for preparing the bracket material ofrepairing damaged bone or cartilage tissue project.

Description

technical field [0001] The invention belongs to the technical field of preparation of polymer biomedical engineering materials, and specifically relates to a biocompatible biodegradable network structure polyacrylamide polyurethane / urea and its preparation method and application. Background technique [0002] Compared with other materials, the application of biodegradable synthetic polymers in medical tissue engineering has the outstanding advantage of being able to adjust the mechanical properties, size, shape, pore size, and degradation performance according to the needs of the application. In addition, polymers can be designed with chemical functionalities that can, for example, induce tissue cell growth or serve to tailor the polymer to a desired application. The most common synthetic polymers used to make growing cell scaffolds and biodegradable inner scaffolds are polyesters such as polylactic acid, polyglycolic acid, polylactide and their copolymers, etc., due to thei...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/62C08F120/56A61L27/18
Inventor 王明慧李通德张书圣
Owner 吴如舟