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Pharmaceutical composition for curing cough

A composition and drug technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of inability to clearly explain the cause of cough, inconvenience for patients with drug side effects, unclear mechanism of action, etc., and achieve simple, non-toxic and excellent effective ingredients. The effect of treating cough, good therapeutic effect

Inactive Publication Date: 2008-05-14
北京中新申康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this type of drug is that it has a narrow scope of application and is only effective for certain types of coughs
[0006] In addition, there are some compound preparations that have both central and peripheral inhibitory effects, but due to the complexity of their formulations, the mechanism of action is unclear.
[0007] However, no matter which of the above-mentioned drugs, it is impossible to clearly explain the cause of cough and cure it from the pathological basis.
Moreover, the side effects of drugs will also bring new inconvenience to patients.

Method used

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  • Pharmaceutical composition for curing cough
  • Pharmaceutical composition for curing cough
  • Pharmaceutical composition for curing cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 medicament oral liquid of the present invention

[0048] (1) Take 20g of American ginseng, add 600ml of water, soak at 30°C for 10h, and then crush it into particles with a diameter of 0.1mm;

[0049] (2) Extract the American ginseng granules together with the soaking solution under reflux at 100°C for 5 hours, filter, leave the solution at 4°C for 10 hours, and take the supernatant;

[0050] (3) Take 30g of tremella, add 900ml of water, soak for 3 hours at a temperature of 25°C, drain off the water, add 900ml of water, and place in an autoclave;

[0051] (4) Extract at a pressure of 0.16Mpa and a temperature of 120°C for 3 hours, take the filtrate, extract twice in total, and combine the filtrates;

[0052] (5) Combine the supernatant obtained in step (2) and the filtrate obtained in step (4), and reflux and concentrate at 100° C. to a concentration of 20 ml / 2 g of raw material.

[0053] According to the preparation method of the oral ...

Embodiment 2

[0054] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0055] (1) Take 20g of American ginseng, add 500ml of water, soak at 45°C for 10h, and then crush it into particles with a diameter of 1mm;

[0056] (2) Extract the American ginseng granules together with the soaking solution under reflux at 100°C for 7 hours, filter, leave the solution at 6°C for 12 hours, and take the supernatant;

[0057] (3) Take 20g of white fungus, add 500ml of water, soak for 2 hours at a temperature of 30°C, drain off the water, add 500ml of water, and place in an autoclave;

[0058] (4) Extract at a pressure of 0.10Mpa and a temperature of 110°C for 6 hours, take the filtrate, extract once in total, and combine the filtrates;

[0059] (5) Combine the supernatant obtained in step (2) and the filtrate obtained in step (4), and reflux and concentrate at 100° C. to a concentration of 20-30ml / 2g raw material.

[0060] (6) Add 95% ethanol to the concentrated solution...

Embodiment 3

[0062] The preparation of embodiment 3 pharmaceutical capsules of the present invention

[0063] (1) Take 20g of American ginseng, add 800ml of water, soak at 55°C for 8h, and then crush it into particles with a diameter of 0.5mm;

[0064] (2) Reflux extract American ginseng granules together with soaking solution at 100°C for 6 hours, filter, and let the solution stand at 4°C for 12 hours, take the supernatant, concentrate to a concentration of 10ml / 1g raw material, add absolute ethanol until the precipitation is complete, The precipitate was filtered, dried and ground into powder;

[0065] (3) Take 20g of white fungus, add 700ml of water, soak for 4 hours at a temperature of 20°C, drain off the water, add 700ml of water, and place in an autoclave;

[0066] (4) Extract at a pressure of 0.20Mpa and a temperature of 125°C for 4 hours, take the filtrate, extract twice in total, combine the filtrates, reflux and concentrate at 100°C to a concentration of 10ml / 1g raw material, ad...

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Abstract

The invention provides a drug combination for curing a cough, comprising a ginseng aqueous extract and a white-fungus aqueous extract. The invention is an oral liquid, a granule, a capsule, a dropping pill, a soft capsule, a tablet, a pill or a coating pill. The invention has the advantages of having strong antitussive effect and quick effect, being safe, acting on peripheral nerve endings, not influencing backbone and having no side effects.

Description

【Technical field】 [0001] The invention relates to the field of medicines, in particular to a medicine composition for treating cough and a preparation method thereof. 【Background technique】 [0002] Cough is a protective airway reflex, which is a physiological reaction caused by an impulse transmitted to the medulla oblongata cough center after the respiratory tract is stimulated (such as inflammation, foreign body). Therefore, coughing is generally a beneficial action and is sometimes seen in healthy humans. In general, for mild and infrequent cough, as long as the sputum or foreign body is discharged, it can be relieved naturally, and there is no need to apply cough medicine. However, for those severe dry cough without phlegm, or severe cough with phlegm that is too frequent, it will not only increase the pain of the patient, affect rest and sleep, increase physical exertion, and even promote the development of the disease, resulting in other complications. profit. Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P11/14A61P11/04A61P25/00
Inventor 谢益宽
Owner 北京中新申康医药科技有限公司