Low molecule heparin mucous membrane adhesive tablet preparations and preparation method thereof
A technology of low-molecular-weight heparin and adhesive tablets, which is applied in the direction of non-active ingredient medical preparations, pill delivery, and pharmaceutical formulations. Cholesterol-lowering effect
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preparation example Construction
[0028] The preparation method of the low molecular weight heparin mucoadhesive tablet preparation comprises the following steps:
[0029] Mix low-molecular-weight heparin, carbomer, and lactose in an appropriate amount, and directly compress the powder into tablets with a diameter of 5mm and a hardness of 4kg. Each tablet contains 20mg-80mg of low-molecular-weight heparin. Then the tablet core was put into a die with a diameter of 7mm, filled with adhesive layer auxiliary materials (Carbomer 974:HPMC K4M ratio 1:1, adhesive layer dosage: 50%) and pressed into an adhesive tablet.
example 1
[0031] The weight composition of low-molecular-weight heparin mucoadhesive tablets containing drug-containing tablet cores includes (dosage per 1000 adhesive tablets)
[0032] Lactose or fructose or sucrose 15g
[0033] Carbomer or natural hydrophilic polymer 15g
[0034] Low molecular weight heparin 20gg
[0035] The weight composition of the adhesive layer of low-molecular-weight heparin mucoadhesive tablets includes (dosage per 1000 adhesive tablets)
[0036] Carbomer or natural gum or polyvinylpyrrolidone 70g
[0037] HPMC or cellulose derivatives 70g
example 2
[0040] The weight composition of low-molecular-weight heparin mucoadhesive tablets containing drug-containing tablet cores includes (dosage per 1000 adhesive tablets)
[0041] Lactose or fructose or sucrose 50g
[0042] Carbomer or natural hydrophilic polymer 50g
[0043] Low molecular weight heparin 80g
[0044] The weight composition of the adhesive layer of low-molecular-weight heparin mucoadhesive tablets includes (dosage per 1000 adhesive tablets)
[0045] Carbomer or natural gum or polyvinylpyrrolidone 200g
[0046] HPMC or cellulose derivatives 200g
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