Unlock instant, AI-driven research and patent intelligence for your innovation.

Sulphuric acid indene land leather slice and preparing method thereof

A technology of indinavir sulfate and indene sulfate, applied in the direction of pill delivery, antiviral agents, etc., can solve the problems of low yield, expensive, high cost, etc., and achieve high yield, low cost, and simple process Effect

Inactive Publication Date: 2008-06-18
ZHUHAI HUAAO IMPORT & EXPORT CORP
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the prior art, when raw material is selected and preparation rate is lower, corresponding cost just remains high, so the relevant medicine of indinavir sulfate currently available on the market is all very expensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sulphuric acid indene land leather slice and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In the present embodiment, the weight of each raw material is respectively:

[0029] 250g of indinavir sulfate, 150g of lactose, 50g of microcrystalline cellulose, 15g of sodium starch glycolate, 20g of crospovidone, 2g of magnesium stearate, and an appropriate amount of ethanol solution. 1000 indinavir sulfate tablets can be prepared, each containing 200 mg of active ingredient indinavir.

[0030] Dosage and dosage:

[0031] Patients infected with human immunodeficiency virus (HIV), orally.

[0032] The usual dosage for adults (the dosage of the active ingredient indinavir) is 800 mg every 8 hours, and the dosage is adjusted according to other drugs taken by the patient at the same time, while the dosage for children is 350-500 mg / m every 8 hours 2 . For full effect, it should be taken regularly within 8 hours, 1 hour before meal or 2 hours after meal.

Embodiment 2

[0034] In the present embodiment, the weight of each raw material is respectively:

[0035] 250g of indinavir sulfate, 200g of lactose, 100g of microcrystalline cellulose, 20g of sodium starch glycolate, 25g of crospovidone, 3g of magnesium stearate, and an appropriate amount of ethanol solution. 1000 indinavir sulfate tablets can be prepared, each containing 200 mg of active ingredient indinavir.

[0036] All the other are the same as embodiment one.

Embodiment 3

[0038] In the present embodiment, the weight of each raw material is respectively:

[0039] 250g of indinavir sulfate, 175g of lactose, 75g of microcrystalline cellulose, 17.5g of sodium starch glycolate, 22.5g of crospovidone, 2.5g of magnesium stearate, and an appropriate amount of ethanol solution. 1000 indinavir sulfate tablets can be prepared, each containing 200 mg of active ingredient indinavir.

[0040] All the other are the same as embodiment one.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an indinavir sulfate tablet and the related preparation method. The indinavir sulfate tablet is made of 250 portions of indinavir sulfate, 150 to 200 portions of lactose, 50 to 100 portions of microcrystalline cellulose, 15 to 20 portions of sodium carboxy methyl starch, 20 to 25 portions of crospovidone, 2 to 3 portions of magnesium stearate and proper amount of ethanol solution (based on weight). The invention has the advantages of high finished product rate and low preparation cost.

Description

technical field [0001] The invention relates to an indinavir sulfate tablet and a preparation method thereof. Background technique [0002] Indinavir sulfate (Indinavir sulfate), the chemical name is [1(1S,2R),-2,3,5-trideoxy-(2,3-dihydrate-2-hydroxy-1H-inden-1-yl )-5-[2-[[(1,1-Dimethyl-ethyl)amino]carbonyl]-4-(3-pyridylmethyl)-1-piperazinyl]-2-(benzyl) -D-erythro-pentanamide sulfate (1:1). Its chemical structural formula is as follows: [0003] [0004] Indinavir sulfate is a specific protease inhibitor. Indinavir directly binds to the active site of protease, so it is a competitive inhibitor of protease. This competitive combination hinders the process of viral particle maturation. The cleavage process of the polyprotein, the resulting immature virus particles are not infectious and cannot establish a new round of infection. Therefore, indinavir sulfate can have an active effect on human immunodeficiency virus (HIV), reduce the amount of human immunodeficiency virus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/496A61K47/38A61P31/18
Inventor 于寅辰
Owner ZHUHAI HUAAO IMPORT & EXPORT CORP