Process for preparing plant sterol ester

A technology of phytosterol esters and phytosterols, which is applied in the green field of chemical synthesis of phytosterol esters, can solve the problems of large dosage and low catalyst activity, and achieve the effect of easy preparation and green synthesis route

Inactive Publication Date: 2008-08-06
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that exists is that catalyst activity is low, and consumption is big (up to 10%), will realize 95% esterification rate, and required

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example

[0027] Examples 1-9 Preparation of fatty acids from soybean oil

[0028] Soybean oil is placed in a high-pressure reactor, and different volumes of distilled water, different types and qualities of antioxidants are added, nitrogen is blown at the bottom for 10 minutes, at different temperatures, nitrogen is blown to the desired pressure, and kept warm and pressure for 2 to 4 hours. Cool down, reduce temperature and reduce pressure. The product is centrifuged, the water phase is removed, and the oil phase is dried with molecular sieve to obtain free mixed fatty acids. The degree of hydrolysis of oil is monitored by TLC method, and the final fatty acid is determined by gas chromatography. The data is shown in Table 1:

[0029] Real

[0030] It can be seen from Table 1 that the degree of hydrolysis increases with the increase of temperature and pressure, but the cost of high-pressure equipment increases significantly, and there are safety problems, so 0.5MPa is preferred. T...

Example

[0031] Example 10-39 Synthesis of sterol esters

[0032] Before the experiment, the sterol material was placed in an oven and dried overnight at 60°C. Fatty acid raw materials are adsorbed and dehydrated by molecular sieve 3A. Weigh a certain quality of mixed phytosterol PS, add a predetermined quality of fatty acid in a 500mL beaker, blow nitrogen, heat the sample in an oil bath, and then heat to the desired temperature and keep it warm. Then, add an appropriate amount of catalyst, stir, and react for 3-12 hours. The intermediate process uses TLC to monitor the esterification process, and the final product uses GC to determine the degree of esterification. The amount of each reactant, the sterol esterification conditions and the esterification rate are shown in Tables 2 to 3:

[0033] Table 2. Effect of catalyst and its dosage on esterification of oleic acid and sterol

[0034] Real

[0035] The fatty acid is oleic acid. The composition of the mixed sterol in Table 2 is...

Example Embodiment

[0040] Example 40.

[0041]According to the esterification operation of Example 33, about 350 grams of the reaction solution was obtained. After the reaction was terminated, the filtrate was filtered hot and the filtrate was transferred to a molecular distiller. The vacuum pressure was 3mmHg and distilled at 120℃. Brown, add 2.8 grams of activated carbon to the heavy phase, stir at 90°C, 100r / min for 2hr, and filter hot to obtain 275 grams of light yellow, clear and transparent sterol ester product.

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PUM

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Abstract

The invention relates to a preparation method of plant sterol ester, which comprises heating fatty acid and phytosterol to 120 to 180DEG C, dissolving, adding catalyst, controlling temperature at 120 to 180DEG C to process esterification for 5-12h, separating and purifying reaction solution to obtain plant sterol ester, wherein the weight ratio of the fatty acid and the phytosterol is 1-5;1, the catalyst is calcium oxide, magnesia or lanthanum oxide or relative mixture, the catalyst is 0.2-3% of the total phytosterol and fatty acid. The preparation method of plant sterol ester uses solvent-free system, while the synthesis route is environment-friendly, effective, simple and suitable for large-scale preparation and separation.

Description

technical field [0001] The invention relates to a preparation method of phytosterol esters, in particular to a green method for chemically synthesizing phytosterol esters in a solvent-free system. Background technique [0002] As we all know, cardiovascular and cerebrovascular diseases are the number one killer of human health, and high blood cholesterol is the most important risk factor for cardiovascular and cerebrovascular diseases. Therefore, blocking or reducing the absorption of cholesterol has become an effective way to prevent and treat cardiovascular and cerebrovascular diseases. Numerous clinical experiments have proved that phytosterols can significantly reduce the absorption of cholesterol and play a role in lowering blood cholesterol. Because it is derived from natural vegetable oil by-products, it has high safety (approved by the FDA as a GRAS substance in 1998), and is especially suitable for patients with mild hypercholesterolemia or added to food as a funct...

Claims

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Application Information

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IPC IPC(8): C07J9/00C07J75/00
Inventor 孟祥河潘秋月邵平孙培龙
Owner ZHEJIANG UNIV OF TECH
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