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Method for preparing low-toxicity nano-carbon tube

A technology of carbon nanotubes and low toxicity, applied in the field of preparation of carbon nanotubes, can solve problems such as affecting application and easy aggregation into bundles, and achieve good water solubility, simple reaction process, and mild reaction conditions

Inactive Publication Date: 2008-11-12
SHANGHAI UNIV
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  • Claims
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Problems solved by technology

However, carbon nanotubes are almost insoluble in any solvent, and are easy to aggregate into bundles in the solution, which seriously affects their application in various aspects.

Method used

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  • Method for preparing low-toxicity nano-carbon tube
  • Method for preparing low-toxicity nano-carbon tube
  • Method for preparing low-toxicity nano-carbon tube

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Embodiment

[0017] (1) Weigh 200 mg of carbon nanotubes with an electronic balance and add them to 320 ml of mixed acid (V concentrated sulfuric acid: V concentrated nitric acid = 3:1) and sonicate for 4 hours. Wash with water after ultrasonic treatment, vacuum microporous filtration with a filter membrane with a pore size of 0.22 μm until the pH value of the filtrate phase is 6-7, and vacuum dry the obtained solid at 60° C. for 24 hours to obtain acidified carbon nanotubes.

[0018] (2) Take 100 mg of acidified carbon nanotubes, put them into a 50 ml round-bottomed flask, add 10 ml of thionyl chloride to sonicate for 30 minutes, and then place them under a magnetic stirrer to vigorously stir and react for 2 days, and the temperature is controlled at 60°C. The solution obtained after the reaction was washed 3-4 times with anhydrous tetrahydrofuran, and the black solid obtained after high-speed centrifugation was dried in a vacuum oven at 60° C. for 24 hours to obtain acid-chlorinated carbo...

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Abstract

The invention relates to a low toxicity carbon Nano-tube and a preparation method thereof. The carbon Nano-tube is a taurine modification carbon Nano-tube formed by a method of covalent modification. The method comprises the detailed steps of: firstly, allowing the acidified carbon Nano-tube to react in thionyl chloride under the temperature of sixty centi degrees and to transform to acyl chlorination carbon Nano-tube, then allowing it to disperse ultrasonically in N and N-DMF solution, and then adding taurine and TEA to obtain carbon Nano-tube modified by taurine through liquid phase reaction under the temperature of one hundred and thirty centi degrees. The carbon Nano-tube modified by taurine is used in a rat experiment which shows that the carbon Nano-tube modified does not cause acute toxicity to the rat, and even under the condition of a high-dose and a long time, only low toxicity is caused to the rat. The carbon Nano-tube modified by taurine prepared through the method has the advantages of good solubility, dispersivity, low toxicity and biocompatibility and can be well applied in drug carriers.

Description

technical field [0001] The invention relates to a method for preparing low-toxicity carbon nanotubes, in particular to a method for preparing taurine-modified carbon nanotubes. Background technique [0002] Carbon nanotubes (CNTs) were discovered by Japanese scholar Iijima under high-resolution transmission electron microscopy (HRTEM) in 1991. As a new type of carbon nanomaterial, due to its unique structural properties, mechanical and electrical properties, it can emit , nanoelectronic devices, atomic force microscope probes, and biological drug carriers have broad application prospects. However, carbon nanotubes are almost insoluble in any solvent, and are easy to aggregate into bundles in solution, which seriously affects their applications in various aspects. For this reason, the surface modification of carbon nanotubes to increase its solubility has gradually become a new research topic. At present, there are two main researches on its modification: covalent modificati...

Claims

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Application Information

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IPC IPC(8): A61K47/12A61K47/00A61K47/48C01B31/02A61K47/02A61K47/20C01B32/168
Inventor 邓小勇孙昱飞熊冬梅吴飞栾启夏王海芳焦正刘元方
Owner SHANGHAI UNIV