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Fingerprint pattern quality determination method of american cockroaches medicinal materials and their extract

A technology of Periplaneta americana and fingerprints, which is applied in the directions of measuring devices, material separation, and analysis of materials, can solve the problems of not being able to control the medicinal materials of Periplaneta americana well, and achieve the effect of stable quality

Active Publication Date: 2011-06-29
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the quality standard of medicinal materials, only the determination of the content of total amino acids and the identification of amino acids are carried out. None of the above methods can better control the quality control of Periplaneta americana medicinal materials, especially the alkaloids of the main active ingredients.
However, there is no report so far on the determination of the HPLC fingerprint method of alkaloids in Periplaneta americana medicinal materials and extracts

Method used

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  • Fingerprint pattern quality determination method of american cockroaches medicinal materials and their extract
  • Fingerprint pattern quality determination method of american cockroaches medicinal materials and their extract
  • Fingerprint pattern quality determination method of american cockroaches medicinal materials and their extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1: the fingerprint quality determination method of Periplaneta americana medical material

[0101] A, the preparation of need testing solution: take Periplaneta americana 5g, add 80% ethanol 100ml, reflux 3 hours, let cool, filter, filtrate reclaims ethanol, puts in 25ml measuring bottle, adds water and dilutes to scale, shakes up, Filter to obtain the filtrate; take the cation exchange resin, grind it, pass through a 50-mesh sieve to remove coarse particles, and then pass through a 150-mesh sieve to remove fine particles, soak in water for 24 hours, pour off the water, and use 2 to 3 times the amount of 2mol / L hydrochloric acid Soak in the solution for 2 hours, stir 4 times at intervals, remove the acid solution, wash with water until nearly neutral, add 4 times the amount of 1mol / L sodium hydroxide solution for 2 hours, stir 4 times at intervals, remove the lye, wash with water until nearly neutral , add 3 times the amount of 2mol / L hydrochloric acid soluti...

Embodiment 2

[0104] Embodiment 2: the method for measuring the fingerprint quality of Periplaneta americana medicinal material

[0105] A, the preparation of need testing solution: take Periplaneta americana 10g, add 90% ethanol 200ml, reflux 1 hour, let cool, filter, filtrate reclaims ethanol, puts in 25ml measuring bottle, adds water and dilutes to scale, shakes up, Filter to obtain the filtrate; take the cation exchange resin, grind it, pass through a 50-mesh sieve to remove coarse particles, and then pass through a 150-mesh sieve to remove fine particles, soak in water for 24 hours, pour off the water, and use 2 to 3 times the amount of 2mol / L hydrochloric acid Soak in the solution for 2 hours, stir 4 times at intervals, remove the acid solution, wash with water until nearly neutral, add 4 times the amount of 1mol / L sodium hydroxide solution for 2 hours, stir 4 times at intervals, remove the lye, wash with water until nearly neutral , add 3 times the amount of 2mol / L hydrochloric acid ...

Embodiment 3

[0108] Embodiment 3: the method for measuring the fingerprint quality of Periplaneta americana medicinal materials

[0109] A, the preparation of need testing solution: take Periplaneta americana, take by weighing 1g, add 60% ethanol 50ml, reflux 8 hours, let cool, filter, filtrate reclaims ethanol, puts in 25ml measuring bottle, adds water and dilutes to scale, Shake well and filter to obtain the filtrate; take the cation exchange resin, grind it, pass through a 50-mesh sieve to remove coarse particles, and then pass through a 150-mesh sieve to remove fine particles, soak in water for 24 hours, pour off the water and use 2-3 times the amount of 2mol Soak in / L hydrochloric acid solution for 2 hours, stir 4 times at intervals, remove acid solution, wash with water until nearly neutral, add 4 times the amount of 1mol / L sodium hydroxide solution for 2 hours, stir 4 times at intervals, remove lye, wash with water To nearly neutral, add 3 times the amount of 2mol / L hydrochloric ac...

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Abstract

The invention relates to a fingerprint quality determining method of American cockroach drug material and extract thereof. With the fingerprint technology applied, the method controls the quality of the American cockroach drug material and extract thereof. The method uses the fingerprint technology to effectively control raw materials from the American cockroach drug material, guarantees the stable quality of the American cockroach drug material under the certain preparing process, thereby further effectively controlling the quality of preparations made from the American cockroach extract, including but not confined to rehabilitation new liquid, rehabilitation new capsule, rehabilitation new pill, rehabilitation new spray, etc. The fingerprint technology provided by the invention can be used as a key means for evaluating the Chinese herbal medicine quality, which is beneficial to the modernization of Chinese herbal medicine.

Description

technical field [0001] The invention relates to a method for measuring the quality of Chinese medicinal materials, in particular to a method for determining the quality of fingerprints of Periplaneta americana medicinal materials and extracts thereof. Background technique [0002] The medicinal materials of Periplaneta americana are recorded in the 1996 edition of "Drug Standards of Yunnan Province", and the main components are amino acids (alanine, leucine, isoleucine, etc.) and alkaloids (uracil, etc.). In the medicinal material quality standard, only the determination of the content of total amino acids and the identification of amino acids are carried out. None of the above methods can better control the quality control of Periplaneta americana medicinal materials, especially the alkaloids of the main active ingredients. However, there is no report so far on the determination of the HPLC fingerprint method for alkaloids in Periplaneta americana medicinal materials and ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 王利春孔繁贵廖军魏胄梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD