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Granisetron hydrochloride mouth spray

A technology of granisetron hydrochloride and oral sprays, which is applied in the field of oral sprays, can solve problems such as restrictions on the use of oral preparations of granisetron hydrochloride, inability to swallow drugs, and patients' reluctance to accept oral antiemetics, so as to avoid nausea Effects of vomiting and improving compliance

Inactive Publication Date: 2008-12-17
南京星银药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, it is found that chemotherapy patients sometimes induce nausea and vomiting due to throat irritation caused by swallowing drugs (solid or liquid), forming a vomiting reaction caused by swallowing, which makes these patients unwilling to accept oral antiemetic drugs; some patients Inability to swallow drug due to dysphagia; these reasons limit the use of convenient and economical oral formulations of granisetron hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Recipe: Granisetron Hydrochloride 11.20g

[0016] Appropriate amount of aspartame

[0017] Potassium sorbate amount

[0018] Purified water to 5000ml

[0019] Makes 1000 bottles

[0020] Preparation method: Take granisetron hydrochloride through a 100-mesh sieve, add an appropriate amount of purified water together with aspartame and potassium sorbate, heat to 60°C and stir to dissolve completely, add purified water to the full amount, and use 0.22 μ micro Pore ​​filter membrane filtration, packaging, inspection.

Embodiment 2

[0022] Recipe: Granisetron Hydrochloride 11.20g

[0023] Sucralose appropriate amount

[0024] Citric acid amount

[0025] Sodium Benzoate Appropriate amount

[0026] Purified water up to 3900ml

[0027] Makes 1000 bottles

[0028] Preparation method: pass the raw materials and auxiliary materials through 100-mesh sieve respectively, take granisetron hydrochloride, add appropriate amount of purified water and stir to dissolve, then add sucralose, citric acid and sodium benzoate, stir to completely dissolve, add purified water to the full amount , the medicinal liquid is filtered with a 0.22μ microporous membrane, subpackaged, and inspected.

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PUM

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Abstract

The invention provides a spray preparation made by mixing granisetron hydrochloride, a pharmaceutically acceptable adjuvant and water for buccal delivery.

Description

technical field [0001] The invention provides an oral spray, in particular to a spray preparation for oral administration prepared by mixing granisetron hydrochloride with pharmaceutically acceptable auxiliary materials and water. Background technique [0002] Granisetron is a highly selective and potent 5-HT 3 Receptor antagonist that acts by highly selectively blocking 5-HT on ventral vagus nerve ending neurons, as well as chemoemetic receptors of the fourth ventricle and intestinal mucosal enterochromaffin cells 3 Receptors to achieve the effect of inhibiting nausea and vomiting. The antiemetic effect of granisetron is 5-11 times stronger than that of ondansetron, and the half-life is 2 times longer, so the effective dose is low and the number of administrations is less. Nausea and vomiting have the advantages of definite curative effect and good safety, and are widely used clinically at home and abroad. Granisetron hydrochloride is actually used in the treatment. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K9/12A61P1/08
Inventor 刘庭福田伟琴刘利根陆效平江剑华
Owner 南京星银药业集团有限公司