Quality control method for Ditong rhinitis drop and mist
A quality inspection method and spray technology, which are used in aerosol delivery, biochemical equipment and methods, and microbial determination/inspection to achieve the effect of ensuring clinical efficacy.
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[0043] Comparison of the preparation methods of Magnolia magnolia test solution:
[0044] Method 1 Take 50ml of this product, put it in a separatory funnel, extract 2 times with ethyl acetate, 15ml each time, combine the ethyl acetate solution, evaporate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution. Prepare magnolia-deficient negative control solution in the same way.
[0045] Method 2 Take 50ml of this product, put it in a separatory funnel, extract 2 times with chloroform, 15ml each time, combine the chloroform solution, evaporate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution. Prepare magnolia-deficient negative control solution in the same way.
[0046] Method 3 Take 20ml of this product, put it in a separatory funnel, extract 2 times with ether, 15ml each time, combine the ether solution, evaporate to dryness, add 1ml of ethanol to the residue to dissolve, and use it as the t...
Embodiment 1
[0124] Quality control steps of Ditong rhinitis water spray:
[0125] 1. Carry out qualitative identification of Magnolia Magnolia in medicine with thin-layer chromatography:
[0126] Take 50ml of Ditong rhinitis water spray, put it in a separatory funnel, extract twice with ethyl acetate, 15ml each time, combine the extracts, evaporate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and add it to a neutral tube with an inner diameter of 9mm. On the alumina column (2-4g), elute with 15ml of methanol, collect the eluate, concentrate to about 1ml, and use it as the test solution. Take another 1 g of magnolia as reference drug, add 15 ml of ethyl acetate, sonicate for 30 minutes, filter, concentrate the filtrate to about 1 ml, add it to a neutral alumina column (2-4 g) with an inner diameter of 9 mm, and elute with 15 ml of methanol. Collect the eluent, concentrate to about 1ml, and use it as the test solution. Then take the magnolanin reference substance, add ...
Embodiment 2
[0143] Embodiment 2: the quality control method of Ditong rhinitis water drops comprises the following steps:
[0144] 1. Carry out qualitative identification of Magnolia Magnolia in medicine with thin-layer chromatography:
[0145] Take 50 ml of Ditong rhinitis water drops, put it in a separatory funnel, extract 2 times with ether, 30 ml each time, combine the extracts, evaporate to dryness, add 1 ml of methanol to the residue to dissolve, add to a neutral alumina column with an inner diameter of 12 mm (2 ~4g), elute with 30ml of ethanol, collect the eluate, concentrate to about 1ml, and use it as the test solution. Take another 1 g of magnolia reference medicinal material, add 30 ml of ether, heat and reflux for 40 minutes, filter, concentrate the filtrate to about 1 ml, add it to a neutral alumina column (2-4 g) with an inner diameter of 12 mm, elute with 30 ml of ethanol, collect and wash Deliquid, concentrated to about 1ml, as the test solution. Then take the magnolin r...
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