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Self-assembling electrode with resveratrol molecular imprinting and method for making same

A technology of resveratrol and molecular imprinting, which is applied in the direction of measuring devices, analytical materials, and electrochemical variables of materials, can solve the problem of poor stability and reproducibility, and there is no literature report on resveratrol molecular imprinting electrochemistry. Preparation and application of chemical sensors to achieve high sensitivity, simple operation, and fast response

Inactive Publication Date: 2011-12-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method has shortcomings such as poor stability and reproducibility.
So far, there have been no literature reports on the preparation and application of molecularly imprinted electrochemical sensors for resveratrol.

Method used

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  • Self-assembling electrode with resveratrol molecular imprinting and method for making same
  • Self-assembling electrode with resveratrol molecular imprinting and method for making same
  • Self-assembling electrode with resveratrol molecular imprinting and method for making same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] 1. Put the ITO glass electrode in acetone for 15 minutes and then put it into a mixed solution of NaOH (1M) and ethanol (volume ratio 1:1) for 15 minutes. Then wash with acetone, ethanol and double distilled water respectively. Sonicate the washed ITO glass in KOH solution for 15min. Then put it into a toluene solution of γ-(methacryloyloxy)propyltrimethoxysilane with a mass fraction of 0.14%, take it out after silanization in a water bath at 60° C. for 24 hours, rinse it with methanol three times, and dry it with nitrogen.

[0052] 2. Weigh 0.038g (0.17mmol) resveratrol and dissolve it in 2mL acetonitrile, add 0.071g (1mmol) functional monomer acrylamide, 0.673g (3.4mmol) cross-linking agent EDMA and 0.01g (0.06mmol) Initiator AIBN is fully mixed, nitrogen gas is passed for 5 minutes, and then ultrasonic degassing is performed for 10 minutes. Then put the above-mentioned silanized ITO glass electrode into the mixed solution, seal the container, put it into a vacuum d...

example 2

[0056] 1. Put the ITO glass electrode in acetone for 15 minutes and then put it into a mixed solution of NaOH (1M) and ethanol (volume ratio 1:1) for 15 minutes. Then wash with acetone, ethanol and double distilled water respectively. Sonicate the washed ITO glass in KOH solution for 15min. Then put it into a toluene solution of γ-(methacryloyloxy)propyltrimethoxysilane with a mass fraction of 0.14%, take it out after silanization in a water bath at 60° C. for 24 hours, rinse it with methanol three times, and dry it with nitrogen.

[0057] 2. Weigh 0.038g (0.17mmol) resveratrol and dissolve it in 2mL acetonitrile, add 0.071g (1mmol) functional monomer acrylamide, 0.914g (2.27mmol) cross-linking agent TRIM and 0.01g (0.06mmol) Initiator AIBN is fully mixed, nitrogen gas is passed for 5 minutes, and then ultrasonic degassing is performed for 10 minutes. Then put the above-mentioned silanized ITO glass electrode into the mixed solution, seal the container, put it into a vacuum ...

example 3

[0061] 1. Put the ITO glass electrode in acetone and sonicate for 15 minutes, then put it into a mixed solution of NaOH (1M) and ethanol (1:1 by volume) and sonicate for 15 minutes. Then wash with acetone, ethanol and double distilled water respectively. Sonicate the washed ITO glass in KOH solution for 15min. Then put it into a toluene solution of γ-(methacryloyloxy)propyltrimethoxysilane with a mass fraction of 0.14%, take it out after silanization in a water bath at 60° C. for 24 hours, rinse it with methanol three times, and dry it with nitrogen.

[0062] 2. Weigh 0.038g (0.17mmol) resveratrol and dissolve it in 2mL acetonitrile, add 0.056g (1mmol) functional monomer acrylic acid, 0.673g (3.4mmol) cross-linking agent AIBN and 0.01g (0.06mmol) initiating The agent AIBN was thoroughly mixed, passed nitrogen for 5 minutes, and then ultrasonic degassed for 10 minutes. Then put the above-mentioned silanized ITO glass electrode into the mixed solution, seal the container, put ...

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Abstract

The invention provides a self-assembled electrode provided with a resveratrol molecular engram. The electrode consists of ITO glass, a siloxane monomolecular layer and a resveratrol molecular engram layer of which the thickness is 0.1 to 1 mu m in turn. The siloxane monomolecular layer is formed by using gama-(methyl acryloyl oxygen) propyl trimethoxy silane as a silanizing agent through a self-assembly method; the resveratrol molecular engram layer contains a polymer which is formed through thermal-initiated polymerization and have a resveratrol engram space; and the engram layer is connected with the siloxane monomolecular layer through a covalent bond formed by the reaction of an olefinic bond of cross linker in the polymer and an olefinic bond in the gama-(methyl acryloyl oxygen) propyl trimethoxy silane. The electrode has better identifying selectivity for resveratrol, and can be used for quick electrochemical detection of high sensitivity and high selectivity of the resveratrol.

Description

technical field [0001] The present invention relates to a method for measuring substances, in particular to a method for analyzing materials by means of determining their chemical properties. Background technique [0002] Resveratrol is a natural stilbene polyphenol substance in plants, which has obvious antibacterial, anti-inflammatory, anti-cancer, anti-thrombosis, anti-hyperlipidemia and other effects. Resveratrol is active in knotweed, mulberry, grape skin, wine and exist in peanuts. At present, the determination of resveratrol at home and abroad generally adopts high-performance liquid chromatography, but it often requires some pretreatment of the extract or wine, such as concentrating the extract under reduced pressure or enriching the wine by solid-phase extraction, etc. , especially for the determination of resveratrol in grapes and wines. Due to the very similar structure of stilbene compounds, the cis-trans isomers of resveratrol have different absorption spectra....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/36G01N27/327
Inventor 向海艳戴开金罗奇志
Owner SOUTHERN MEDICAL UNIVERSITY
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