Marker for function check of stomach and intestine and preparation method thereof

A technology for gastrointestinal function and markers, which is applied in the direction of X-ray contrast agent preparation, etc., can solve problems such as affecting the accuracy of inspection results, and achieve the effects of good popularization and practical value, easy production and manufacturing, and both form and function.

Inactive Publication Date: 2009-08-05
莱芜钢铁集团有限公司医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Specifically, all examinations will inevitably have a certain impact on the function of the gastrointestinal tract, whi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1:

[0036]1000 grams of medical barium sulfate, 15 grams of glucomannan, 10 grams of edible alkali, and 100 ml of water. Dissolve glucomannan in water, stir and heat. After the solution boils, add 10 grams of edible alkali to 10ml of water to dissolve, pour into the glucomannan solution and stir, then add barium sulfate to adjust it to a dough-like structure. Then it is processed and cut to form a granular structure with a diameter of 2 mm, which is then dried, and the dried granules are filled into capsules.

[0037] The size of each capsule is 3X5mm, and a single capsule weighs about 2 grams after being filled with medicine. The finished product of 1000 grams of barium sulfate contains about 500 capsules. During the examination, each patient takes 10 capsules (approximately 20 grams) orally to achieve the purpose of the examination. The medicine prepared according to the above requirements can be used for 50 examinations.

Example Embodiment

[0038] Example 2:

[0039] 450 grams of medical barium sulfate, 6 grams of glucomannan, 4 grams of edible alkali, and 50 ml of water. Dissolve glucomannan in water, stir and heat. After the solution boils, add 4 grams of edible alkali to 10ml of water to dissolve it, pour into the glucomannan solution and stir, then add barium sulfate to adjust it to a dough-like structure. Then it is processed and cut to form a granular structure with a diameter of 2 mm, which is then dried, and the dried granules are filled into capsules.

[0040] The size of each capsule is 3X5mm. A single capsule weighs about 2 grams after being filled with medicine. The 450 grams of barium sulfate product contains about 230 capsules. During the examination, each patient takes 10 capsules (approximately 20 grams) by mouth to achieve the purpose of the examination. The medicine prepared according to the above requirements can be used for 23 examinations.

Example Embodiment

[0041] Example 3:

[0042] 750 grams of medical barium sulfate, 7 grams of glucomannan, 6 grams of edible alkali, and 60 ml of water. Dissolve glucomannan in water, stir and heat. After the solution boils, add 6 grams of edible alkali to 10ml of water to dissolve, pour into the glucomannan solution and stir, then add barium sulfate to adjust it to a dough-like structure. It is then processed and cut to form a granular structure with a diameter of 2 mm, which is then dried, and the dried granules are filled into capsules.

[0043] The size of each capsule is 3X5mm, and a single capsule weighs about 2 grams when filled with medicine. The finished product of 750 grams of barium sulfate contains about 380 capsules. During the examination, each patient takes 10 capsules (approximately 20 grams) by mouth to achieve the purpose of the examination. The medicine prepared according to the above requirements can be used for 38 examinations.

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Abstract

The invention relates to the preparation of a medicine which is used special for the examination of gastrointestinal tract functions of human bodies and can develop under X rays after the oral administration. The medicine is formed by adding an X ray material [B] with high dilatability, high viscosity and low absorption during the preparation, a material [C] which plays a role in solidification and agglomeration, and water [D] into a contrast agent, wherein the contrast agent takes metal salts (such as barium sulfate, and the like) [A] which have no toxicity, are not absorbed by the human bodies, and have high atomic number as main materials; and [A]+[B]+[C]+[D] is equal to 50-99%+0.5-10%+0.5-5%+1-40%=100%(w/w). The invention has the advantages of reasonable design formulation, economy and practicality, safe oral administration, no toxic and side effect, and accurate and reliable detection result, cannot produce a false negative or false positive result, has the characteristics of synchronously having morphology and function, and can provide an advantageous evidence for clinical diagnosis and treatment.

Description

Technical field [0001] The invention belongs to the technical field of preparations for human body tests, and specifically relates to a medicine which can be developed under X-ray after oral administration and is specially used for checking the dynamic function and digestion and decomposition ability of human digestive tract and its preparation method. Background technique [0002] The function of the human gastrointestinal tract includes two aspects: dynamic emptying and digestion and absorption. At present, there have been research reports on the detection of gastrointestinal emptying ability, but due to certain limitations, it has not been widely used in clinical practice. , The digestion and absorption function of the gastrointestinal tract is based on the premise of the grinding and digestion of food by the gastrointestinal tract. It can be expressed by its ability to digest food. However, we have also not found any research and application on human gastrointestinal di...

Claims

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Application Information

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IPC IPC(8): A61K49/04
Inventor 牟健民孟桂兰王世东谭乐成张盈张玉民苏明杰牟童
Owner 莱芜钢铁集团有限公司医院
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