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Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof

A technology for effective parts and diabetes, which is applied in the field of effective parts of traditional Chinese medicine compound prescriptions for the treatment of diabetes and the field of preparation thereof, and can solve the problems of toxic and side effects, adverse reactions, large number of patients and the like

Inactive Publication Date: 2011-05-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the current clinically used hypoglycemic drugs for the treatment of type 2 diabetes, various western medicines have certain limitations and adverse reactions, even very serious adverse reactions, such as hypoglycemia, lactic acidosis, etc.
The treatment of diabetes has always been a hot spot in clinical medical research and new drug development. In view of the fact that Western medicine treatment often brings great toxic and side effects to patients while achieving curative effect
Moreover, Western medicine has no advantage in the treatment of diabetic complications.

Method used

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  • Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof
  • Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Prescription: 20g of Digupi, 20g of Ghost Arrow Feather, 6g of Coptis, and 12g of Cornus.

[0030] (2) Preparation of the effective part of the prescription drug: take the prescription drug and add 5 times the amount of water, decoct and extract for 1 hour, filter, keep the filtrate, add 5 times the amount of water to the drug residue, decoct and extract for 1 hour, filter, combine the two filtrates, and decompress Concentration; the concentrate is enriched on a macroporous resin column, eluted with 50%-70% ethanol, collected the eluate, recovered the solvent under reduced pressure, and concentrated to 3g crude drug / ml to obtain the effective part of the Chinese medicine compound for treating diabetes.

Embodiment 2

[0032] (1) Prescription: 30g of Digu Bark, 30g of Ghost Arrow Feather, 9g of Coptis, and 18g of Cornus.

[0033] (2) Preparation of the effective part of the prescription drug: take the prescription drug and add 5 times the amount of water, decoct and extract for 1 hour, filter, keep the filtrate, add 5 times the amount of water to the drug residue, decoct and extract for 1 hour, filter, combine the two filtrates, and decompress Concentration; the concentrate is enriched on a macroporous resin column, eluted with 50%-70% ethanol, collected the eluate, recovered the solvent under reduced pressure, and concentrated to 3g crude drug / ml to obtain the effective part of the Chinese medicine compound for treating diabetes.

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Abstract

The invention relates to an active part of a traditional Chinese medicine composite for curing diabetes. The active part is prepared from root-bark of Chinese wolfberry, ramulus euonymi, coptis chinensis and dogwood according to weight proportion. A preparation method of the actively part comprises the following steps: weighing all the medicinal materials of a prescription; decocting the medicinal materials with water with an amount which is 5 times of that of the medicinal materials; filtering; remaining filtrate; adding water with an amount which is 5 times of that of decoction dregs into the decoction dregs; decocting; filtering; combining filtrates obtained from the two times of decocting; depressurize and concentrating the combined filtrate; applying concentrated liquid on a macroporous resin column for purpose of enrichment; eluting by using ethanol with a certain concentration; collecting eluent; depressurizing and recovering solvent; concentrating the solvent to a density of 3g of crude drug per milliliter; and obtaining the active part of the traditional Chinese medicine composite for curing diabetes. In the invention, a theory of traditional Chinese medical science is followed, namely three heats (i.e. dryness-heat, moist heat and stagnant heat) are symptoms and deficiency of qi and yin as well as hepatic and renal deficiency is as root cause, wherein the symptoms and the root causes interact as both causes and effects. The active part of the traditional Chinese medicine composite for curing diabetes on a basis of a three-heat theory is obtained. As being demonstrated by pharmacologic tests, the active part in small dosage can obviously reduce blood sugar content of a model mouse, and can achieve extremely obvious reduction of the blood sugar content of the model mouse in medium / high dosage.

Description

1. Technical Field: [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an effective part of a traditional Chinese medicine compound for treating diabetes and a preparation method thereof. 2. Background technology [0002] With the aging of the world population, diabetes has become a common and frequently-occurring disease. There are about 120 million diabetic patients in the world, 80% of which are non-insulin dependent diabetes (type 2), of which 20 million are in my country. The number of deaths caused by complications of diabetes in developed countries ranks third after cardiovascular and cerebrovascular diseases and cancer, and has attracted great attention from all over the world (Li Zhihao Research Progress in Diabetes Therapy of Chinese Medicine. Journal of Hangzhou Normal University (Medical Edition) , 2007, 27(1): 58). [0003] The biggest feature of diabetes is that the course of the disease is long and complicated, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61P3/10
Inventor 皮文霞邱蓉丽许桂玲郭戎许波华
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE